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https://www.readbyqxmd.com/read/29927770/hepatitis-delta-in-patients-with-resolved-hepatitis-b-virus-infection
#1
Antonio Aguilera, Javier Rodríguez-Calviño, Carmen de Mendoza, Vincent Soriano
BACKGROUND: The hepatitis delta virus (HDV) causes the most aggressive form of chronic viral hepatitis. As HDV replication requires hepatitis B virus (HBV), HDV screening is limited to HBsAg+ carriers. To date, individuals with HDV-antibodies and markers of resolved hepatitis B are considered cured. However, a subset shows elevated liver enzymes and hepatic fibrosis. Could they represent HBsAg-seronegative occult HDV infections? METHODS: We tested for HDV-antibodies 406 individuals with markers of past HBV exposure...
June 20, 2018: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29912972/characterisation-of-the-hepatitis-b-virus-cross-species-transmission-pattern-via-na-taurocholate-co-transporting-polypeptides-from-11-new-world-and-old-world-primate-species
#2
Simon F Müller, Alexander König, Barbara Döring, Dieter Glebe, Joachim Geyer
The hepatic Na+/taurocholate co-transporting polypeptide (NTCP in man, Ntcp in animals) is the high-affinity receptor for the hepatitis B (HBV) and hepatitis D (HDV) viruses. Species barriers for human HBV/HDV within the order Primates were previously attributed to Ntcp sequence variations that disable virus-receptor interaction. However, only a limited number of primate Ntcps have been analysed so far. In the present study, a total of 11 Ntcps from apes, Old and New World monkeys were cloned and expressed in vitro to characterise their interaction with HBV and HDV...
2018: PloS One
https://www.readbyqxmd.com/read/29910856/hepatitis-d-virus-infection-in-kermanshah-west-of-iran-seroprevalence-and-viremic-infections
#3
Babak Sayad, Yosra Naderi, Seyed Moayed Alavian, Farid Najafi, Alireza Janbakhsh, Feyzollah Mansouri, Siavash Vaziri, Mandana Afsharian, Fatemeh Norooznezhad
Aim: This study aimed to determine the seroprevalence and viremic infection of hepatitis delta virus (HDV) in Kermanshah. Background: Hepatitis delta is one of the most complex viral infections of liver that along with hepatitis B virus could lead to fulminant hepatitis, progressive chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Methods: Referrals with positive HBs Ag were included and tested for HDV Ab using ELISA. Seropositives were subsequently evaluated for viremia by assaying HDV RNA and HBV DNA using real-time PCR...
2018: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/29906637/molecular-epidemiology-of-hepatitis-delta-and-hepatitis-b-viruses-circulating-in-two-major-provinces-east-and-north-west-of-pakistan
#4
Mahwish Aftab, Iram Amin, Muhammad Idrees, Amjad Ali, Shazia Rafique, Shagufta Naz
OBJECTIVES: HBV and HDV are major public health problems with millions affected globally and Pakistan accounts for a significant proportion of the global Hepatitis burden. This cross sectional study was designed to assess the general epidemiological and virological features of HBV and HDV in the Punjab and Khyber Pakhtunkhawa (KP) provinces of Pakistan. METHODS: A total of 1890 HBV patients from March 2016 to May 2017 were recruited in the study and the presence of HDV was retrospectively evaluated in all participants...
June 12, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29888837/viral-dominance-patterns-in-chronic-hepatitis-delta-determine-early-response-to-interferon-alpha-therapy
#5
Gunnar Lewon Lutterkort, Anika Wranke, Julia Hengst, Cihan Yurdaydin, Judith Stift, Birgit Bremer, Svenja Hardtke, Onur Keskin, Ramazan Idilman, Michael P Manns, Hans Peter Dienes, Christine Falk, Heiner Wedemeyer, Benjamin Heidrich
Chronic hepatitis D is caused by coinfection of hepatitis B and hepatitis D virus. While HDV is the dominant virus over HBV in the majority of cases, mechanisms and consequences of viral dominances are largely unknown. We aimed to investigate associations between viral dominance patterns and patients' characteristics and inflammatory features. 109 HDV patients treated with PEG-IFNa-2a within the international multicentre, prospective HIDIT-2 trial were studied. Patients were classified as D- or B-dominant if the viral load of one virus exceeded that of the other virus by more than 1log10 ...
June 11, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29883351/clinical-and-laboratory-characteristics-of-hepatitis-d-in-republic-of-sakha-yakutia
#6
Vadim G Krivoshapkin, Sergei I Semenov, Svetlana S Maximova, Nadegda N Tihonova, Anna I Sivtseva, Snegana S Sleptsova
OBJECTIVE: Inrtroduction: The epidemiological situation for hepatitis D has changed significantly. Reduced population authors infection due to a sharp decline in hospitalizations from Central Asia regions, the Caucasus and Moldova, which are known to be endemic for hepatitis D. Currently, the incidence of chronic hepatitis D (HGD) in Russia is 1%, while in the countries of Central Asia, and in particular in Turkmenistan, the share of HGD among chronic viral hepatitis is 8%. The aim of research was to establish the clinical features, depending on the activity of the replication of hepatitis viruses B and D...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29858376/molecular-signature-and-mechanisms-of-hepatitis-d-virus-associated-hepatocellular-carcinoma
#7
Giacomo Diaz, Ronald E Engle, Ashley Tice, Marta Melis, Stephanie Montenegro, Jaime Rodriguez-Canales, Jeffrey Hanson, Michael R Emmert-Buck, Kevin W Bock, Ian N Moore, Fausto Zamboni, Sugantha Govindarajan, David Kleiner, Patrizia Farci
There is limited data on the molecular mechanisms whereby hepatitis D virus (HDV) promotes liver cancer. Therefore, serum and liver specimens obtained at the time of liver transplantation from well-characterized patients with HDV-HCC (n-5) and with non-HCC HDV cirrhosis (n=7) were studied using an integrated genomic approach. Transcriptomic profiling was performed using laser capture-microdissected (LCM) malignant and non-malignant hepatocytes, tumorous and non-tumorous liver tissue from patients with HDV-HCC, and liver tissue from patients with non-HCC HDV cirrhosis...
June 1, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29851188/epidemiology-and-patient-characteristics-of-hepatitis-d-virus-infection-in-the-west-of-scotland-2011-2016
#8
Celia Jackson, Rory N Gunson, Amanda Bradley-Stewart, Susan Bennet, Heather Black, Nicholas Kennedy, David J Bell
Worldwide 15-20 million individuals are infected with hepatitis delta virus (HDV) [1] . It is a small, single stranded RNA virus that is only able to infect individuals also infected with hepatitis B (HBV). It is transmitted sexually, via blood and perinatally. Those who are co-infected with HBV and HDV are at greater risk of liver fibrosis, earlier hepatic decompensation, liver cirrhosis and have an increased risk of hepatocellular carcinoma compared to those with HBV alone [1] . The only effective treatment for HDV is pegylated interferon...
May 31, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29844854/clinical-epidemiology-of-chronic-viral-hepatitis-b-a-tuscany-real-word-large-scale-cohort-study
#9
Cristina Stasi, Caterina Silvestri, Roberto Berni, Maurizia Rossana Brunetto, Anna Linda Zignego, Cristina Orsini, Stefano Milani, Liana Ricciardi, Andrea De Luca, Pierluigi Blanc, Cesira Nencioni, Donatella Aquilini, Alessandro Bartoloni, Giampaolo Bresci, Santino Marchi, Franco Filipponi, Piero Colombatto, Paolo Forte, Andrea Galli, Sauro Luchi, Silvia Chigiotti, Alessandro Nerli, Giampaolo Corti, Rodolfo Sacco, Paola Carrai, Angelo Ricchiuti, Massimo Giusti, Paolo Almi, Andrea Cozzi, Silvia Carloppi, Giacomo Laffi, Fabio Voller, Francesco Cipriani
AIM: To build a regional database of chronic patients to define the clinical epidemiology of hepatitis B virus (HBV)-infected patients in the Tuscan public health care system. METHODS: This study used a cross-sectional cohort design. We evaluated chronic viral hepatitis patients with HBV referred to the outpatient services of 16 hospital units. Information in the case report forms included main demographic data, blood chemistry data, viral hepatitis markers, instrumental evaluations, and eligibility for treatment or ongoing therapy and liver transplantation...
May 27, 2018: World Journal of Hepatology
https://www.readbyqxmd.com/read/29800369/hepatitis-d-viremia-among-injection-drug-users-in-san-francisco
#10
Parag Mahale, Peter V Aka, Xiaohua Chen, Ping Liu, Benjamin J Fram, Alan S Wang, Scott Simenel, Fan-Chen Tseng, Sabrina Chen, Brian R Edlin, Jeffrey S Glenn, Thomas R O'Brien
People who inject drugs (PWID) are commonly exposed to hepatitis B virus (HBV) and hepatitis D virus (HDV). We evaluated the prevalence of HDV viremia among hepatitis B surface antigen (HBsAg)-positive PWID (n = 73) using a new quantitative microarray antibody capture (Q-MAC) assay, HDV western blot, and HDV RNA. HDV Q-MAC performed well in this cohort: anti-HDV, 100% sensitivity and specificity; HDV viremia, 61.5% sensitivity and 100% specificity. Hepatitis D viremia was present in 35.6% of HBsAg-positive participants and was more common in those with resolved compared to chronic hepatitis C (5...
May 25, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29795302/hdv-infection-rates-in-northern-vietnam
#11
Mai Thanh Binh, Nghiem Xuan Hoan, Hoang Van Tong, Dao Phuong Giang, Bui Tien Sy, Nguyen Linh Toan, Le Huu Song, Mai Hong Bang, Heiner Wedemeyer, Christian G Meyer, Peter G Kremsner, C-Thomas Bock, Thirumalaisamy P Velavan
Hepatitis D caused by the hepatitis delta virus (HDV) is a serious health problem in many regions of the world. A total of 546 HBV-infected patients were enrolled from 2013 to 2015 and classified clinically into the subgroups of chronic hepatitis B (CHB, n = 191), liver cirrhosis (LC, n = 147) and hepatocellular carcinoma (HCC, n = 208). The patients were screened for HDV-RNA by nested PCR assays. HDV genotypes were assessed by direct sequencing, followed by phylogenetic analysis. HDV-RNA was identified in 13% (71/546) of HBV-infected patients...
May 23, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29790323/-prevalence-and-risk-factors-of-overweight-and-obesity-after-liver-transplantation-retrospective-study-at-three-years-after-transplantation
#12
Sara Di Cosmo, Maura Lusignani, Matteo Manini, Roberto Accardi
BACKGROUND AND AIM: Weight gain is frequently observed among liver transplanted patients. This condition is often associated to the development of other post LT morbidities which might influence the long-term post-transplant survival. However, the risk factors asso- ciated have not yet been identified. The aim of this study was to assess the prevalence of over- weight and obesity, to notice Body Mass Index changes and associated risk factors, within three years after LT. METHODS: All the patients consecutively transplanted at the Liver Transplantation Unit of Fondazione IRCCS "Cà-Granda Ospedale Maggiore Policlinico", Milan between January 2005 and June 2014 were retrospectively evaluated for inclusion...
January 2018: Professioni Infermieristiche
https://www.readbyqxmd.com/read/29785877/hepatitis-b-virus-lymphotropism-emerging-details-and-challenges
#13
Shivali S Joshi, Carla S Coffin
The hepatitis B virus (HBV) is predominantly a hepatotropic virus but also infects cells of the lymphatic system. HBV genomes (DNA, messenger (m)RNA, covalently closed circular (ccc) DNA) and proteins have been found in extrahepatic sites such as peripheral blood mononuclear cells (PBMC), lymph nodes, spleen, bone marrow and cerebrospinal fluid. HBV entry into hepatocytes occurs by binding of the HBV preS1 surface protein to its specific receptor, the bile acid transporter, sodium taurocholate co-transporting polypeptide (NTCP)...
April 2018: Biotechnology & Genetic Engineering Reviews
https://www.readbyqxmd.com/read/29779957/de-novo-macrocyclic-peptide-inhibitors-of-hepatitis-b-virus-cellular-entry
#14
Toby Passioura, Koichi Watashi, Kento Fukano, Satomi Shimura, Wakana Saso, Ryo Morishita, Yuki Ogasawara, Yasuhito Tanaka, Masashi Mizokami, Camille Sureau, Hiroaki Suga, Takaji Wakita
Hepatitis B virus (HBV) constitutes a significant public health burden, and currently available treatment options are not generally curative, necessitating the development of new therapeutics. Here we have applied random non-standard peptide integrated discovery (RaPID) screening to identify small macrocyclic peptide inhibitors of HBV entry that target the cell-surface receptor for HBV, sodium taurocholate cotransporting polypeptide (NTCP). In addition to their anti-HBV activity, these molecules also inhibit cellular entry by the related hepatitis D virus (HDV), and are active against diverse strains of HBV (including clinically relevant nucleos(t)ide analog-resistant and vaccine escaping strains)...
May 2, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29776712/erratum-to-a-new-hdv-mouse-model-identifies-mitochondrial-antiviral-signaling-protein-mavs-as-a-key-player-in-ifn-%C3%AE-induction-j-hepatol-67-2017-669-679
#15
Lester Suárez-Amarán, Carla Usai, Marianna Di Scala, Cristina Godoy, Yi Ni, Mirja Hommel, Laura Palomo, Víctor Segura, Cristina Olagüe, Africa Vales, Alicia Ruiz-Ripa, Maria Buti, Eduardo Salido, Jesús Prieto, Stephan Urban, Francisco Rodríguez-Frias, Rafael Aldabe, Gloria González-Aseguinolaza
No abstract text is available yet for this article.
May 15, 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29775812/virus-entry-and-its-inhibition-to-prevent-and-treat-hepatitis-b-and-hepatitis-d-virus-infections
#16
REVIEW
Thomas Tu, Stephan Urban
While chronic infection with the human hepatitis B virus (HBV) and hepatitis delta virus (HDV) inflict major health burdens worldwide, current therapies cannot cure patients. One possible novel approach is blocking virus entry to prevent the establishment of infection in naïve hepatocytes. As HBV and HDV use identical viral envelope proteins and the same entry mechanisms, such a strategy would target both viruses. Entry inhibitors (e.g. neutralizing antibodies) have been relegated to the limited role of prophylaxis...
June 2018: Current Opinion in Virology
https://www.readbyqxmd.com/read/29761607/epidemiology-and-phylogenetic-analysis-of-hepatitis-d-virus-infection-in-australia
#17
Kathy Jackson, Jennifer MacLachlan, Benjamin Cowie, Stephen Locarnini, D Scott Bowden, Nasra Higgins, Theo Karapanagiotidis, Suellen Nicholson, Margaret Littlejohn
BACKGROUND: The incidence and trends in hepatitis D virus (HDV) in Australia have not been recently assessed and the circulating genotypes have never been determined. AIM: This study aimed to characterise the current virology and epidemiology of HDV. METHODS: Notifiable disease surveillance and laboratory testing data were analysed to assess demographics, risk factors, and trends. HDV serology and RNA testing were performed on requested samples from 2010-2016...
May 14, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29761292/-chronic-hepatitis-b-and-d-delta-current-and-future-treatments
#18
REVIEW
N Wortmann, C Höner Zu Siederdissen, M Cornberg
BACKGROUND: Worldwide, hepatitis B virus (HBV) infection is among the 30 leading causes of death, despite effective vaccination and therapeutic options. Chronic hepatitis delta (coinfection with hepatitis D virus) leads to a rapid disease progression. AIMS: Based on current international guidelines and studies, an overview about present and future therapeutic options for chronic hepatitis B and delta is provided. RESULTS: Therapy with nucleoside or nucleotide analogues leads to nearly complete HBV DNA suppression, which is associated with regression of liver fibrosis and a lower risk for the development of hepatocellular carcinoma...
May 14, 2018: Der Internist
https://www.readbyqxmd.com/read/29743374/common-and-distinct-capsid-and-surface-protein-requirements-for-secretion-of-complete-and-genome-free-hepatitis-b-virions
#19
Xiaojun Ning, Laurie Luckenbaugh, Kuancheng Liu, Volker Bruss, Camille Sureau, Jianming Hu
During the morphogenesis of hepatitis B virus (HBV), an enveloped virus, two types of virions are secreted: (1) a minor population of complete virions containing a mature nucleocapsid with the characteristic, partially double-stranded, relaxed circular DNA genome and (2) a major population containing an empty capsid with no DNA or RNA (empty virions). Secretion of both types of virions requires interactions between the HBV capsid or core protein (HBc) and the viral surface or envelope proteins. We have studied the requirements from both HBc and envelope proteins for empty virion secretion, in comparison with those for secretion of complete virions...
May 9, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29742524/prevalence-and-incidence-of-hepatitis-delta-in-patients-with-chronic-hepatitis-b-in-spain
#20
Antonio Aguilera, Rocio Trastoy, Javier Rodríguez-Calviño, Tamara Manso, Carmen de Mendoza, Vicente Soriano
BACKGROUND: Hepatitis delta virus (HDV) is a defective agent that only replicates in the presence of the hepatitis B virus. Accordingly, HDV acquisition may occur as superinfection of HBsAg+ carriers or following acute dual HDV and hepatitis B virus exposure. Herein, we examined the global and incident rates of HDV infections in Spain. PATIENTS AND METHODS: The presence of anti-HDV antibody and new HDV superinfections was examined in all HBsAg+ patients who attended one large tertiary outclinic in Spain since year 2000...
May 8, 2018: European Journal of Gastroenterology & Hepatology
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