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https://www.readbyqxmd.com/read/27902514/prevalence-and-epidemiology-of-hepatitis-d-among-patients-with-chronic-hepatitis-b-virus-infection-a-report-from-northern-spain
#1
Carlos Ordieres, Carmen A Navascués, María L González-Diéguez, Mercedes Rodríguez, Valle Cadahía, María Varela, Luis Rodrigo, Manuel Rodríguez
BACKGROUND: The incidence of hepatitis delta virus (HDV) infection has decreased during the last decades. However, an increasing trend has been reported recently. PATIENTS AND METHODS: We carried out a case-control study to analyze changes in its prevalence in 1215 chronic hepatitis B virus (HBV) patients, diagnosed consecutively in a tertiary center, between 1983 and 2012. According to the year of diagnosis, patients were distributed into two groups: A [1983-1997 (n=786)] and B [1998-2012 (n=429)]...
November 29, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27894309/analysis-of-long-noncoding-rna-expression-in-hepatocellular-carcinoma-of-different-viral-etiology
#2
Quan Zhang, Kentaro Matsuura, David E Kleiner, Fausto Zamboni, Harvey J Alter, Patrizia Farci
BACKGROUND: Dysregulation of long noncoding RNA (lncRNA) expression contributes to the pathogenesis of many human diseases, including liver diseases. Several lncRNAs have been reported to play a role in the development of hepatocellular carcinoma (HCC). However, most studies have analyzed lncRNAs only in hepatitis B virus (HBV)-related HCC or in a single group of HCC patients regardless of the viral etiology. METHODS: To investigate whether lncRNAs are differentially expressed in HCC of different viral etiology, we profiled 101 disease-related lncRNAs, including 25 lncRNAs previously associated with HCC, in liver specimens obtained from well-characterized patients with HBV-, hepatitis C virus (HCV)-, or hepatitis D virus (HDV)-associated HCC...
November 28, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27881614/performance-characteristics-of-a-new-consensus-commercial-kit-for-hepatitis-d-virus-rna-viral-load-quantification
#3
Frédéric Le Gal, Samira Dziri, Athenaïs Gerber, Chakib Alloui, Zahia Ben Abdesselam, Dominique Roulot, Ségolène Brichler, Emmanuel Gordien
Hepatitis Delta virus (HDV) is responsible for fulminant hepatitis and liver failure, and accelerates evolution towards cirrhosis and hepatocellular carcinoma in hepatitis B virus-infected patients. To date treatment relies upon long-term administration of pegylated alpha-interferon with sustained virological response in 30% of the patients. Very recently, new promising anti HDV therapies have been developed and are already used in clinical trials. HDV-RNA viral load (HDVL) monitoring must be an integral part of the management of the infected-patients...
November 23, 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27880976/a-novel-quantitative-microarray-antibody-capture-q-mac-assay-identifies-an-extremely-high-hdv-prevalence-amongst-hbv-infected-mongolians
#4
Xiaohua Chen, Odgerel Oidovsambuu, Ping Liu, Rosslyn Grosely, Menashe Elazar, Virginia D Winn, Benjamin Fram, Zhang Boa, Hongjie Dai, Bekhbold Dashtseren, Dahgwahdorj Yagaanbuyant, Zulkhuu Genden, Naranbaatar Dashdorj, Andreas Bungert, Naranjargal Dashdorj, Jeffrey S Glenn
: Hepatitis delta virus (HDV) causes the most severe form of human viral hepatitis. HDV requires a hepatitis B virus (HBV) co-infection to provide HDV with HBV surface antigen envelope proteins. The net effect of HDV is to make the underlying HBV disease worse, including higher rates of hepatocellular carcinoma (HCC). Accurate assessments of current HDV prevalence have been hampered by the lack of readily available and reliable quantitative assays, combined with the absence of an FDA-approved therapy...
November 23, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27821080/a-prominent-role-of-hepatitis-d-virus-in-liver-cancers-documented-in-central-africa
#5
Marie Atsama Amougou, Dominique Noah Noah, Paul Fewou Moundipa, Pascal Pineau, Richard Njouom
BACKGROUND: Hepatocellular Carcinoma (HCC) is one of the commonest cancers in Central Africa, a region with the unusual peculiarity to be hyperendemic for infections with Hepatitis B, C and D viruses. However, data estimating the respective proportions of HCC cases attributable to these viruses are still limited in this area. The current study was undertaken to determine the role of these viruses in HCC compared to non-HCC Cameroonian patients. METHODS: A case-control study was conducted in the Gastroenterology Unit of Central Hospital of Yaounde in collaboration with Centre Pasteur of Cameroon...
November 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27821029/long-term-efficacy-of-pegylated-%C3%A4-nterferone-in-the-treatment-of-delta-hepatitis-a-single-center-experience
#6
Z M Y Kılıç, A S Köksal, I H Kalkan, N Suna, H Yıldız, S Kacar
BACKGROUND AND AIM: Currently there is no satisfactory treatment of chronic HDV. We aimed to evaluate the long term efficacy of PEG-interferones. PATIENTS METHODS: Patients who received PEG-interferone for chronic delta hepatitis during a 7-year period were retrospectively analysed. End of treatment response, virologic response at 6 months after treatment, and long term efficacy were evaluated. Predictors of treatment response were determined. RESULTS: The study group consisted of 31 patients...
July 2016: Acta Gastro-enterologica Belgica
https://www.readbyqxmd.com/read/27813124/noninvasive-markers-for-staging-fibrosis-in-chronic-delta-hepatitis
#7
V Takyar, P Surana, D E Kleiner, K Wilkins, J H Hoofnagle, T J Liang, T Heller, C Koh
BACKGROUND: Serum fibrosis markers are useful in staging chronic hepatitis B (HBV) and C (HCV) virus but have not been evaluated in chronic hepatitis D virus (HDV). AIM: To evaluate the utility of serum fibrosis markers [fibrosis-4 score (FIB-4), aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio, aspartate aminotransferase ratio (AAR), age-platelet index (API), AST-to-platelet-ratio-index (APRI) and Hui score] in HDV infection. METHODS: Clinical and histologic laboratory data from HBV, HCV and HDV patients were evaluated and serum fibrosis markers were calculated...
January 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27807029/cellular-nuclear-export-factors-tap-and-aly-are-required-for-hdag-l-mediated-assembly-of-hepatitis-delta-virus
#8
Hsiu-Chen Huang, Chung-Pei Lee, Hui-Kang Liu, Ming-Fu Chang, Yu-Heng Lai, Yu-Ching Lee, Cheng Huang
Hepatitis delta virus (HDV) is a satellite virus of hepatitis B virus (HBV). HDV genome encodes two forms of hepatitis delta antigen (HDAg), small HDAg (HDAg-S), which is required for viral replication, and large HDAg (HDAg-L), which is essential for viral assembly. HDAg-L is identical to HDAg-S except that it bears a 19 amino acid extension at the C terminus. Both HDAgs contain a nuclear localization signal (NLS), but only HDAg-L contains a CRM1-independent nuclear export signal at its C terminus. The nuclear export activity of HDAg-L is important for HDV particle formation...
November 2, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27803174/the-third-signal-cytokine-il-12-rather-than-immune-checkpoint-inhibitors-contribute-to-the-functional-restoration-of-hepatitis-d-virus-specific-t-cells
#9
Thomas Schirdewahn, Jan Grabowski, Solomon Owusu Sekyere, Birgit Bremer, Anika Wranke, Sebastian Lunemann, Verena Schlaphoff, Janina Kirschner, Svenja Hardtke, Michael Peter Manns, Markus Cornberg, Heiner Wedemeyer, Pothakamuri Venkata Suneetha
BACKGROUND:  Hepatitis D virus (HDV) infection affects 15-20 million individuals world-wide and causes severely progressive hepatitis. It is unknown to what extent cellular immune responses contribute to liver disease and control of viral replication in HDV infection. METHODS:  Immune cell frequencies and phenotypes were determined in 49 HDV-infected patients, 25 HBV-monoinfected individuals and 18 healthy controls. T-cell proliferative and cytokine-producing capacities were analysed by stimulation with overlapping peptides spanning the large HDV antigen...
October 31, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27792905/antiviral-therapy-of-hepatitis-delta-virus-infection-progress-and-challenges-towards-cure
#10
REVIEW
Anika Wranke, Heiner Wedemeyer
Hepatitis B-/D-virus co-infection causes the most severe form of viral hepatitis, frequently leading to liver cirrhosis, hepatic decompensation and consecutive liver-related mortality. Treatment options for hepatitis delta are limited. The only recommended therapy is pegylated interferon alpha which leads to virological responses in about 25-30% of patients. However, interferon therapy is associated with frequent side-effects and late HDV RNA relapses have been described during long-term follow even in patients who were HDV RNA negative 24 weeks after the end of therapy...
October 25, 2016: Current Opinion in Virology
https://www.readbyqxmd.com/read/27783949/solute-carrier-ntcp-regulates-innate-antiviral-immune-responses-targeting-hepatitis-c-virus-infection-of-hepatocytes
#11
Eloi R Verrier, Che C Colpitts, Charlotte Bach, Laura Heydmann, Laetitia Zona, Fei Xiao, Christine Thumann, Emilie Crouchet, Raphaël Gaudin, Camille Sureau, François-Loïc Cosset, Jane A McKeating, Patrick Pessaux, Yujin Hoshida, Catherine Schuster, Mirjam B Zeisel, Thomas F Baumert
Chronic hepatitis B, C, and D virus (HBV, HCV, and HDV) infections are the leading causes of liver disease and cancer worldwide. Recently, the solute carrier and sodium taurocholate co-transporter NTCP has been identified as a receptor for HBV and HDV. Here, we uncover NTCP as a host factor regulating HCV infection. Using gain- and loss-of-function studies, we show that NTCP mediates HCV infection of hepatocytes and is relevant for cell-to-cell transmission. NTCP regulates HCV infection by augmenting the bile-acid-mediated repression of interferon-stimulated genes (ISGs), including IFITM3...
October 25, 2016: Cell Reports
https://www.readbyqxmd.com/read/27775592/prokaryotic-expression-purification-and-immunogenicity-in-rabbits-of-the-small-antigen-of-hepatitis-delta-virus
#12
Vera L Tunitskaya, Olesja V Eliseeva, Vladimir T Valuev-Elliston, Daria A Tyurina, Natalia F Zakirova, Olga A Khomich, Martins Kalis, Oleg E Latyshev, Elizaveta S Starodubova, Olga N Ivanova, Sergey N Kochetkov, Maria G Isaguliants, Alexander V Ivanov
Hepatitis delta virus (HDV) is a viroid-like blood-borne human pathogen that accompanies hepatitis B virus infection in 5% patients. HDV has been studied for four decades; however, the knowledge on its life-cycle and pathogenesis is still sparse. The studies are hampered by the absence of the commercially-available HDV-specific antibodies. Here, we describe a set of reproducible methods for the expression in E. coli of His-tagged small antigen of HDV (S-HDAg), its purification, and production of polyclonal anti-S-HDAg antibodies in rabbits...
October 20, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27774349/a-two-metal-ion-mediated-conformational-switching-pathway-for-hdv-ribozyme-activation
#13
Tai-Sung Lee, Brian K Radak, Michael E Harris, Darrin M York
RNA enzymes serve as a potentially powerful platform from which to design catalysts and engineer new biotechnology. A fundamental understanding of these systems provides insight to guide design. The hepatitis delta virus ribozyme (HDVr) is a small, self-cleaving RNA motif widely distributed in nature, that has served as a paradigm for understanding basic principles of RNA catalysis. Nevertheless, questions remain regarding the precise roles of divalent metal ions and key nucleotides in catalysis. In an effort to establish a reaction mechanism model consistent with available experimental data, we utilize molecular dynamics simulations to explore different conformations and metal ion binding modes along the HDVr reaction path...
2016: ACS Catalysis
https://www.readbyqxmd.com/read/27771387/hdv-rna-replication-is-associated-with-hbv-repression-and-interferon-stimulated-genes-induction-in-super-infected-hepatocytes
#14
Dulce Alfaiate, Julie Lucifora, Natali Abeywickrama-Samarakoon, Maud Michelet, Barbara Testoni, Jean-Claude Cortay, Camille Sureau, Fabien Zoulim, Paul Dény, David Durantel
Hepatitis D virus (HDV) super-infection of Hepatitis B virus (HBV)-infected patients is the most aggressive form of viral hepatitis. HDV infection is not susceptible to direct anti-HBV drugs, and only suboptimal antiviral responses are obtained with interferon (IFN)-alpha-based therapy. To get insights on HDV replication and interplay with HBV in physiologically relevant hepatocytes, differentiated HepaRG (dHepaRG) cells, previously infected or not with HBV, were infected with HDV, and viral markers were extensively analyzed...
October 19, 2016: Antiviral Research
https://www.readbyqxmd.com/read/27770553/antiviral-treatment-and-liver-related-complications-in-hepatitis-delta
#15
Anika Wranke, Beatriz Calle Serrano, Benjamin Heidrich, Janina Kirschner, Birgit Bremer, Patrick Lehmann, Svenja Hardtke, Katja Deterding, Kerstin Port, Max Westphal, Michael P Manns, Markus Cornberg, Heiner Wedemeyer
: Hepatitis delta virus (HDV) is the most severe form of viral hepatitis. Pegylated interferon alfa (PEG-IFNα) is effective in only 25%-30% of patients and is associated with frequent side effects. The aim of this study was to analyze the clinical long-term outcome of hepatitis delta in relation to different antiviral treatment strategies. We studied 136 anti-HDV-positive patients who were followed for at least 6 months in a retrospective single-center cohort (mean time of follow-up, 5...
October 22, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27754501/regulation-of-map4k4-gene-expression-by-rna-interference-through-an-engineered-theophylline-dependent-hepatitis-delta-virus-ribozyme-switch
#16
Hui Cheng, Yuanyuan Zhang, Hongyan Wang, Na Sun, Min Liu, Hongxia Chen, Renjun Pei
Riboswitches are functional non-coding RNA regulatory components that play an important role in the regulation of gene expression in diverse organisms. In particular, using riboswitches to modulate RNA interference (RNAi) enables temporal and spatial control of gene expression in mammalian cells. Herein, a ribozyme gene switch to activate RNAi was fabricated for the artificial regulation of versatile gene silencing through the interaction of an RNA aptamer with small molecules. The device comprised an allosteric HDV ribozyme with an embedded theophylline aptamer and a primary miRNA (pri-miRNA) to silence the MAP4K4 gene in hepatic (HepG2) cells, aiming to achieve dose-dependent control of the activation of RNAi, and then the regulation of the MAP4K4 gene by theophylline...
October 18, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27753688/the-hepatitis-d-satellite-virus-of-hepatitis-b-virus-half-opening-a-new-era-to-control-viral-infection
#17
Natali Abeywickrama-Samarakoon, Jean-Claude Cortay, Paul Dény
PURPOSE OF REVIEW: To highlight new concepts and therapeutic approaches concerning hepatitis D virus (HDV) infection. RECENT FINDINGS: Common receptor for hepatitis B virus (HBV) and HDV has been elucidated, deciphering of HDV replication is still in progress, preliminary results of phase II proof-of-concept clinical assays for entry inhibitors and cellular farnesyl transferase inhibitors are now available. SUMMARY: Hepatitis D infection remains a severe acute and chronic liver illness with the only currently approved therapy (Peg-αIFN) achieving disappointingly low rates of sustained viral response and clinical improvement...
October 7, 2016: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27748305/presence-of-acute-hepatitis-d-infection-in-hbsag-positive-cancer-patients-a-preliminary-study-from-west-gujarat
#18
Foram Maulin Patel, Parijath N Goswami
BACKGROUND & OBJECTIVES: Hepatitis delta virus (HDV) and hepatitis B virus (HBV) co-infection is well known to induce a spectrum of acute and chronic liver diseases. There has been global decline in the prevalence of hepatitis D infection. The aim of the present study was to know the presence of acute HDV infection among hepatitis B surface antigen (HBsAg) positive cancer patients. METHODS: A total of 5043 samples were subjected for routine testing of HBV, HIV and HCV by ELISA method...
June 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27746337/hepatitis-delta-associated-mortality-in-hiv-hbv-coinfected-patients
#19
Charles Béguelin, Darius Moradpour, Roland Sahli, Franziska Suter-Riniker, Alexander Lüthi, Matthias Cavassini, Huldrych F Günthard, Manuel Battegay, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, Dominique L Braun, Hansjakob Furrer, Andri Rauch, Gilles Wandeler
BACKGROUND & AIMS: Hepatitis delta virus (HDV) infection accelerates the progression of hepatitis B virus (HBV)-related liver disease. We assessed the epidemiological characteristics of HDV infection in the nationwide Swiss HIV Cohort Study and evaluated its impact on clinical outcomes. METHODS: All HIV-infected patients with a positive hepatitis B surface antigen test were considered and tested for anti-HDV antibodies. HDV amplification and sequencing were performed in anti-HDV-positive patients...
October 14, 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27742037/hepatitis-d-virus-infections-among-injecting-drug-users-with-and-without-human-immunodeficiency-virus-infection-in-taiwan
#20
Meng-Hsuan Hsieh, Shu-Chi Wang, Ming-Yen Hsieh, Chung-Feng Huang, Ming-Lun Yeh, Jeng-Fu Yang, Ko Chang, Wei-Ru Lin, Chun-Yu Lin, Tun-Chieh Chen, Jee-Fu Huang, Chia-Yen Dai, Jih-Jin Tsai, Wan-Long Chuang, Ming-Lung Yu
In Taiwan, injecting drug use has been the main route of human immunodeficiency virus (HIV) transmission since 2005, with hepatitis B virus (HBV) and hepatitis D virus (HDV) also having similar transmission routes. This has now become an important public health issue. The aim of this study is to explore the conditions of HDV infections between injecting drug users (IDUs) with and without HIV infection in Southern Taiwan. In this study, 87 IDUs were enrolled, including 27 anti-HDV seronegative IDUs and 60 anti-HDV seropositive IDUs, and the results of their liver function tests, CD4 cell counts, and anti-HIV and HIV RNA levels were analyzed...
October 2016: Kaohsiung Journal of Medical Sciences
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