Kailong Wen, Zhuoyue Shi, Peijia Yu, Lillian Mo, Shivang Sullere, Victor Yang, Nate Westneat, Jeff A Beeler, Daniel S McGehee, Brent Doiron, Xiaoxi Zhuang
Loss of dopamine neurons causes motor deterioration in Parkinson's disease patients. We have previously reported that in addition to acute motor impairment, the impaired motor behavior is encoded into long-term memory in an experience-dependent and task-specific manner, a phenomenon we refer to as aberrant inhibitory motor learning. Although normal motor learning and aberrant inhibitory learning oppose each other and this is manifested in apparent motor performance, in the present study, we found that normal motor memory acquired prior to aberrant inhibitory learning remains preserved in the brain, suggesting the existence of independent storage...
February 28, 2024: bioRxiv