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Novel motor learning

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https://www.readbyqxmd.com/read/28729951/young-children-do-not-require-perceptual-motor-feedback-to-solve-aesop-s-fable-tasks
#1
Rachael Miller, Sarah A Jelbert, Elsa Loissel, Alex H Taylor, Nicola S Clayton
Aesop's Fable tasks-in which subjects drop objects into a water-filled tube to raise the water level and obtain out-of-reach floating rewards -have been used to test for causal understanding of water displacement in both young children and non-human animals. However, a number of alternative explanations for success on these tasks have yet to be ruled out. One hypothesis is that subjects may respond to perceptual-motor feedback: repeating those actions that bring the reward incrementally closer. Here, we devised a novel, forced-choice version of the Aesop's Fable task to assess whether subjects can solve water displacement tasks when this type of feedback is removed...
2017: PeerJ
https://www.readbyqxmd.com/read/28729730/a-selective-inhibitor-of-histone-deacetylase-3-prevents-cognitive-deficits-and-suppresses-striatal-cag-repeat-expansions-in-huntington-s-disease-mice
#2
Nuria Suelves, Lucy Kirkham-McCarthy, Robert S Lahue, Silvia Ginés
Huntington's disease (HD) is a neurodegenerative disorder whose major symptoms include progressive motor and cognitive dysfunction. Cognitive decline is a critical quality of life concern for HD patients and families. The enzyme histone deacetylase 3 (HDAC3) appears to be important in HD pathology by negatively regulating genes involved in cognitive functions. Furthermore, HDAC3 has been implicated in the aberrant transcriptional patterns that help cause disease symptoms in HD mice. HDAC3 also helps fuel CAG repeat expansions in human cells, suggesting that HDAC3 may power striatal expansions in the HTT gene thought to drive disease progression...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28692658/temporal-specificity-of-the-initial-adaptive-response-in-motor-adaptation
#3
Wilsaan M Joiner, Gary C Sing, Maurice A Smith
Repeated exposure to a novel physical environment eventually leads to a mature adaptive response whereby feedforward changes in motor output mirror both the amplitude and temporal structure of the environmental perturbations. However, adaptive responses at the earliest stages of learning have been found to be not only smaller, but systematically less specific in their temporal structure compared to later stages of learning. This observation has spawned a lively debate as to whether the temporal structure of the initial adaptive response is, in fact, stereotyped and non-specific...
July 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28690001/synergistic-interaction-between-dexmedetomidine-and-ulinastatin-against-vincristine-induced-neuropathic-pain-in-rats
#4
Bilin Nie, Subo Zhang, Zhuxi Huang, Jingxiu Huang, Xiaodi Chen, Yaochao Zheng, Xiaohui Bai, Weian Zeng, Handong Ouyang
Anti-microtubulin chemotherapeutic agents such as vincristine (VCR), often induce peripheral neuropathic pain. It is usually permanent and seriously harmful to cancer patients' quality of life quality and can result in the hampering of clinical treatments. Currently, there is no definitive therapy, and many of the drugs approved for the treatment of other neuropathic pain have shown little or no analgesic effect. It is therefore vital to find new and novel therapeutic strategies for patients suffering from chemotherapeutic agent-induced neuropathic pain in order to improve patients' quality of life...
July 6, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28685651/successful-transfer-of-a-motor-learning-strategy-to-a-novel-sport
#5
Philip E Kearney, Phil Judge
This study investigated whether secondary school students who were taught a motor learning strategy could transfer their knowledge of the strategy to learning a novel task. Twenty adolescents were randomly allocated to a strategy or control group. The strategy group was taught Singer's five-step learning strategy, while the control group received information on the evolution and biomechanics of the basketball free throw. Both groups received three 1-hour practice sessions on a modified basketball shooting task...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28668553/the-recovery-response-to-a-novel-unannounced-laboratory-induced-slip-the-first-trial-effect-in-older-adults
#6
Xuan Liu, Sasha Reschechtko, Shuaijie Wang, Yi-Chung Clive Pai
BACKGROUND: After a single slip, older adults rapidly make adaptive changes to avoid or eliminate further backward loss of balance or a fall. This rapid adaptation has been termed the "single trial effect". The purpose of this study was to explore the relationship between the motor errors subjects experienced upon a novel slip and the selection and execution of corrective response by which they modified their ongoing gait pattern and turned it into a protective step. METHODS: A forward slip was induced in the laboratory among 145 community-living older (≥65year old) adults who were protected by an overhead full body harness system...
June 17, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28668279/the-influence-of-high-intensity-exercise-and-the-val66met-polymorphism-on-circulating-bdnf-and-locomotor-learning
#7
Erin E Helm, Kathleen S Matt, Kenneth F Kirschner, Ryan T Pohlig, Dave Kohl, Darcy S Reisman
Brain-derived neurotrophic factor (BDNF) has been directly related to exercise-enhanced motor performance in the neurologically injured animal model; however literature concerning the role of BDNF in the enhancement of motor learning in the human population is limited. Previous studies in healthy subjects have examined the relationship between intensity of an acute bout of exercise, increases in peripheral BDNF and motor learning of a simple isometric upper extremity task. The current study examined the role of high intensity exercise on upregulation of peripheral BDNF levels as well as the role of high intensity exercise in mediation of motor learning and retention of a novel locomotor task in neurologically intact adults...
June 29, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28659467/motor-learning-in-a-complex-balance-task-and-associated-neuroplasticity-a-comparison-between-endurance-athletes-and-non-athletes
#8
Oliver Seidel, Daniel Carius, Rouven Kenville, Patrick Ragert
Studies suggested that motor expertise is associated with functional and structural brain alterations, which positively affect sensorimotor performance and learning capabilities. The purpose of the present study was to unravel differences in motor skill learning and associated functional neuroplasticity between endurance athletes (EA) and non-athletes (NA). For this purpose, participants had to perform a multimodal balance task (MBT) training on two sessions which were separated by one week. Before and after MBT-training, a static balance task (SBT) had to be performed...
June 28, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28655043/the-impact-of-feedback-frequency-on-performance-in-a-novel-speech-motor-learning-task
#9
Mara Steinberg Lowe, Adam Buchwald
Purpose: This study investigated whether whole nonword accuracy, phoneme accuracy, and acoustic duration measures were influenced by the amount of feedback speakers without impairment received during a novel speech motor learning task. Method: Thirty-two native English speakers completed a nonword production task across 3 time points: practice, short-term retention, and long-term retention. During practice, participants received knowledge of results feedback according to a randomly assigned schedule (100%, 50%, 20%, or 0%)...
June 22, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28655042/a-novel-investigation-of-generalized-motor-program-theory-syllable-stress-as-a-motor-class-variable
#10
Kimberly M Meigh
Purpose: This experiment evaluated syllable-stress position as a motor class directed by a syllable-sized generalized motor program. Reaction times were predicted to be slower for stimuli with untrained stress patterns outside the trained motor class. Furthermore, reaction times were predicted to be stable for untrained stimuli within the same motor class regardless of phonetic similarity. Method: Twenty-three young adults with typical speech and hearing participated in a motor-learning study comprised of motor-class training and a judgment task...
June 22, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28647814/the-effects-of-variable-practice-on-locomotor-adaptation-to-a-novel-asymmetric-gait
#11
Jacob W Hinkel-Lipsker, Michael E Hahn
Very little is known about the effects of specific practice on motor learning of predictive balance control during novel bipedal gait. This information could provide an insight into how the direction and magnitude of predictive errors during acquisition of a novel gait task influence transfer of balance control, as well as yield a practice protocol for the restoration of balance for those with locomotor impairments. This study examined the effect of a variable practice paradigm on transfer of a novel asymmetric gait pattern in able-bodied individuals...
June 24, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28646563/cohesive-network-reconfiguration-accompanies-extended-training
#12
Qawi K Telesford, Arian Ashourvan, Nicholas F Wymbs, Scott T Grafton, Jean M Vettel, Danielle S Bassett
Human behavior is supported by flexible neurophysiological processes that enable the fine-scale manipulation of information across distributed neural circuits. Yet, approaches for understanding the dynamics of these circuit interactions have been limited. One promising avenue for quantifying and describing these dynamics lies in multilayer network models. Here, networks are composed of nodes (which represent brain regions) and time-dependent edges (which represent statistical similarities in activity time series)...
June 24, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28638591/replicable-in-vivo-physiological-and-behavioral-phenotypes-of-the-shank3b-null-mutant-mouse-model-of-autism
#13
Sameer C Dhamne, Jill L Silverman, Chloe E Super, Stephen H T Lammers, Mustafa Q Hameed, Meera E Modi, Nycole A Copping, Michael C Pride, Daniel G Smith, Alexander Rotenberg, Jacqueline N Crawley, Mustafa Sahin
BACKGROUND: Autism spectrum disorder (ASD) is a clinically and biologically heterogeneous condition characterized by social, repetitive, and sensory behavioral abnormalities. No treatments are approved for the core diagnostic symptoms of ASD. To enable the earliest stages of therapeutic discovery and development for ASD, robust and reproducible behavioral phenotypes and biological markers are essential to establish in preclinical animal models. The goal of this study was to identify electroencephalographic (EEG) and behavioral phenotypes that are replicable between independent cohorts in a mouse model of ASD...
2017: Molecular Autism
https://www.readbyqxmd.com/read/28636677/contextual-imitation-of-intransitive-body-actions-in-a-beluga-whale-delphinapterus-leucas-a-do-as-other-does-study
#14
José Z Abramson, Mª Victoria Hernández-Lloreda, José-Antonio Esteban, Fernando Colmenares, Francisco Aboitiz, Josep Call
Cetaceans are remarkable for exhibiting group-specific behavioral traditions or cultures in several behavioral domains (e.g., calls, behavioral tactics), and the question of whether they can be acquired socially, for example through imitative processes, remains open. Here we used a "Do as other does" paradigm to experimentally study the ability of a beluga to imitate familiar intransitive (body-oriented) actions demonstrated by a conspecific. The participant was first trained to copy three familiar behaviors on command (training phase) and then was tested for her ability to generalize the learned "Do as the other does" command to a different set of three familiar behaviors (testing phase)...
2017: PloS One
https://www.readbyqxmd.com/read/28629225/cortical-plasticity-in-depression
#15
Mariagiovanna Cantone, Alessia Bramanti, Giuseppe Lanza, Manuela Pennisi, Placido Bramanti, Giovanni Pennisi, Rita Bella
Neural plasticity is considered the neurophysiological correlate of learning and memory, although several studies have also noted that it plays crucial roles in a number of neurological and psychiatric diseases. Indeed, impaired brain plasticity may be one of the pathophysiological mechanisms that underlies both cognitive decline and major depression. Moreover, a degree of cognitive impairment is frequently observed throughout the clinical spectrum of mood disorders, and the relationship between depression and cognition is often bidirectional...
May 2017: ASN Neuro
https://www.readbyqxmd.com/read/28625547/contextual-fear-conditioning-is-enhanced-in-mice-lacking-functional-sphingosine-kinase-2
#16
Mona Lei, Adeena Shafique, Kani Shang, Timothy A Couttas, Hua Zhao, Anthony S Don, Tim Karl
The lipid sphingosine 1-phosphate (S1P) is a potent neuroprotective signalling molecule that signals through its own family of five G-protein coupled receptors. S1P signalling enhances presynaptic glutamate release and is essential for neural development. S1P is synthesized by the enzymes sphingosine kinases 1 and 2 (SPHK1 and SPHK2), of which SPHK2 mRNA and activity is more abundant in the brain. In this study we investigated the consequences of global SphK2 knockout (SphK2(-/-)) on basic motor capabilities, anxiety, learning, and memory in mice, using a range of tests including the elevated plus maze, the cheeseboard, contextual and cued fear conditioning, and fear extinction...
June 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28623611/deferiprone-rescues-behavioral-deficits-induced-by-mild-iron-exposure-in-a-mouse-model-of-alpha-synuclein-aggregation
#17
Eleonora Carboni, Lars Tatenhorst, Lars Tönges, Elisabeth Barski, Vivian Dambeck, Mathias Bähr, Paul Lingor
Parkinson's disease (PD) is the most common neurodegenerative movement disorder, and its causes remain unknown. A major hallmark of the disease is the increasing presence of aggregated alpha-synuclein (aSyn). Furthermore, there is a solid consensus on iron (Fe) accumulation in several regions of PD brains during disease progression. In our study, we focused on the interaction of Fe and aggregating aSyn in vivo in a transgenic mouse model overexpressing human aSyn bearing the A53T mutation (prnp.aSyn.A53T). We utilized a neonatal iron-feeding model to exacerbate the motor phenotype of the transgenic mouse model...
June 16, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28622637/children-benefit-differently-from-night-and-day-time-sleep-in-motor-learning
#18
Jin H Yan
Motor skill acquisition occurs while practicing (on-line) and when asleep or awake (off-line). However, developmental questions still remain about whether children of various ages benefit similarly or differentially from night- and day-time sleeping. The likely circadian effects (time-of-day) and the possible between-test-interference (order effects) associated with children's off-line motor learning are currently unknown. Therefore, this study examines the contributions of over-night sleeping and mid-day napping to procedural skill learning...
June 13, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28599953/naps-improve-new-walkers-locomotor-problem-solving
#19
Sarah E Berger, Anat Scher
In this first study of the impact of sleep on infants' problem solving of a locomotor task, 28 newly walking infants who were within a week of having given up crawling trained to navigate a shoulder-height tunnel to reach a caregiver waiting at the end. During the transitional window between crawling and walking, infants are reluctant to return to crawling, making this task uniquely challenging. Infants were randomly assigned to either nap or stay awake during a delay between training and a later test session...
June 6, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28587561/short-term-motor-learning-and-retention-during-visually-guided-walking-in-persons-with-multiple-sclerosis
#20
Kayla McGowan, Shaila M Gunn, Galina Vorobeychik, Daniel S Marigold
BACKGROUND: The ability to adapt, a form of short-term motor learning, and retain this adaptation, is essential for rehabilitation and for day-to-day living. Yet little research is available on this topic in persons with multiple sclerosis (PwMS), particularly in relation to complex walking tasks. OBJECTIVE: To determine the ability of PwMS to learn and retain a novel relationship between visual input and motor output-or visuomotor map-during visually guided walking...
July 2017: Neurorehabilitation and Neural Repair
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