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High fructose corn syrup

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https://www.readbyqxmd.com/read/28507007/perspective-a-historical-and-scientific-perspective-of-sugar-and-its-relation-with-obesity-and-diabetes
#1
Richard J Johnson, Laura G Sánchez-Lozada, Peter Andrews, Miguel A Lanaspa
Fructose-containing added sugars, such as sucrose and high-fructose corn syrup, have been experimentally, epidemiologically, and clinically shown to be involved in the current epidemics of obesity and diabetes. Here we track this history of intake of sugar as it relates to these epidemics. Key experimental studies that have identified mechanisms by which fructose causes obesity and diabetes are reviewed, as well as the evidence that the uricase mutation that occurred in the mid-Miocene in ancestral humans acted as a "thrifty gene" that increases our susceptibility for fructose-associated obesity today...
May 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28447343/impact-of-perinatal-exposure-to-sucrose-or-high-fructose-corn-syrup-hfcs-55-on-adiposity-and-hepatic-lipid-composition-in-rat-offspring
#2
Carla R Toop, Beverly S Muhlhausler, Kerin O'Dea, Sheridan Gentili
Perinatal exposure to excess maternal intake of added sugars, including fructose and sucrose, is associated with an increased risk of obesity and type 2 diabetes in adult life. However, it is unknown to what extent the type of sugar and the timing of exposure affect these outcomes. The aim of this study was to determine the impact of exposure to maternal consumption of a 10% w/v beverage containing sucrose or high fructose corn syrup-55 (HFCS-55) during the prenatal and/or suckling periods on offspring at 3 and 12 weeks, utilising a cross-fostering approach in a rodent model...
April 26, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28445436/irritable-bowel-syndrome-clinical-manifestations-dietary-influences-and-management
#3
REVIEW
Ronald Ikechi, Bradford D Fischer, Joshua DeSipio, Sangita Phadtare
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder that is characterized by symptoms of chronic abdominal pain and altered bowel habits in the absence of an overtly identifiable cause. It is the most commonly diagnosed functional gastrointestinal disorder, accounting for about one third of gastroenterology visits. It generally presents as a complex of symptoms, including psychological dysfunction. Hypersensitivity to certain foods, especially foods that contain high amounts of fructose, plays a role in the pathophysiology of IBS...
April 26, 2017: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/28445389/fructose-glucocorticoids-and-adipose-tissue-implications-for-the-metabolic-syndrome
#4
REVIEW
Balázs Legeza, Paola Marcolongo, Alessandra Gamberucci, Viola Varga, Gábor Bánhegyi, Angiolo Benedetti, Alex Odermatt
The modern Western society lifestyle is characterized by a hyperenergetic, high sugar containing food intake. Sugar intake increased dramatically during the last few decades, due to the excessive consumption of high-sugar drinks and high-fructose corn syrup. Current evidence suggests that high fructose intake when combined with overeating and adiposity promotes adverse metabolic health effects including dyslipidemia, insulin resistance, type II diabetes, and inflammation. Similarly, elevated glucocorticoid levels, especially the enhanced generation of active glucocorticoids in the adipose tissue due to increased 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) activity, have been associated with metabolic diseases...
April 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28347724/metabolic-effects-of-intermittent-access-to-caloric-or-non-caloric-sweetened-solutions-in-mice-fed-a-high-caloric-diet
#5
Marion Soto, Catherine Chaumontet, Patrick C Even, Dalila Azzout-Marniche, Daniel Tomé, Gilles Fromentin
Human consumption of obesogenic diets and soft drinks, sweetened with different molecules, is increasing worldwide, and increases the risk of metabolic diseases. We hypothesized that the chronic consumption of caloric (sucrose, high-fructose corn syrup (HFCS), maltodextrin) and non-caloric (sucralose) solutions under 2-hour intermittent access, alongside the consumption of a high-fat high-sucrose diet, would result in differential obesity-associated metabolic abnormalities in mice. Male C57BL/6 mice had ad libitum access to an HFHS diet and to water (water control group)...
June 1, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28285356/immobilization-of-recombinant-glucose-isomerase-for-efficient-production-of-high-fructose-corn-syrup
#6
Li-Qun Jin, Qi Xu, Zhi-Qiang Liu, Dong-Xu Jia, Cheng-Jun Liao, De-Shui Chen, Yu-Guo Zheng
Glucose isomerase is the important enzyme for the production of high fructose corn syrup (HFCS). One-step production of HFCS containing more than 55% fructose (HFCS-55) is receiving much attention for its industrial applications. In this work, the Escherichia coli harboring glucose isomerase mutant TEGI-W139F/V186T was immobilized for efficient production of HFCS-55. The immobilization conditions were optimized, and the maximum enzyme activity recovery of 92% was obtained. The immobilized glucose isomerase showed higher pH, temperature, and operational stabilities with a K m value of 272 mM and maximum reaction rate of 23...
March 11, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28244665/fodmaps-food-composition-defining-cutoff-values-and-international-application
#7
REVIEW
Jane Varney, Jacqueline Barrett, Kate Scarlata, Patsy Catsos, Peter R Gibson, Jane G Muir
The low-FODMAP diet is a new dietary therapy for the management of irritable bowel syndrome that is gaining in popularity around the world. Developing the low-FODMAP diet required not only extensive food composition data but also the establishment of "cutoff values" to classify foods as low-FODMAP. These cutoff values relate to each particular FODMAP present in a food, including oligosaccharides (fructans and galacto-oligosaccharides), sugar polyols (mannitol and sorbitol), lactose, and fructose in excess of glucose...
March 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28209058/rare-sugar-syrup-containing-d-allulose-but-not-high-fructose-corn-syrup-maintains-glucose-tolerance-and-insulin-sensitivity-partly-via-hepatic-glucokinase-translocation-in-wistar-rats
#8
Tomoya Shintani, Takako Yamada, Noriko Hayashi, Tetsuo Iida, Yasuo Nagata, Nobuaki Ozaki, Yukiyasu Toyoda
Ingestion of high-fructose corn syrup (HFCS) is associated with the risk of both diabetes and obesity. Rare sugar syrup (RSS) has been developed by alkaline isomerization of HFCS and has anti-obesity and anti-diabetic effects. However, the influence of RSS on glucose metabolism has not been explored. We investigated whether long-term administration of RSS maintains glucose tolerance and whether the underlying mechanism involves hepatic glucokinase translocation. Wistar rats were administered water, RSS, or HFCS in drinking water for 10 weeks and then evaluated for glucose tolerance, insulin tolerance, liver glycogen content, and subcellular distribution of liver glucokinase...
March 9, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28193326/properties-of-a-novel-thermostable-glucose-isomerase-mined-from-thermus-oshimai-and-its-application-to-preparation-of-high-fructose-corn-syrup
#9
Dong-Xu Jia, Lin Zhou, Yu-Guo Zheng
Glucose isomerase (GI) is used in vitro to convert d-glucose to d-fructose, which is capable of commercial producing high fructose corn syrup (HFCS). To manufacture HFCS at elevated temperature and reduce the cost of enriching syrups, novel refractory GIs from Thermoanaerobacterium xylanolyticum (TxGI), Thermus oshimai (ToGI), Geobacillus thermocatenulatus (GtGI) and Thermoanaerobacter siderophilus (TsGI) were screened via genome mining approach. The enzymatic characteristics research showed that ToGI had higher catalytic efficiency and superior thermostability toward d-glucose among the screened GIs...
April 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28070314/calories-and-sugars-in-boba-milk-tea-implications-for-obesity-risk-in-asian-pacific-islanders
#10
Jae Eun Min, David B Green, Loan Kim
In the last several decades, obesity rates have reached epidemic proportions, and increases the risk for a host of comorbidities, including diabetes, cardiovascular disease, and certain kinds of cancers. Boba milk tea, first became popular in the 1990s throughout Asia, and has gained more popularity in the United States and in Europe since 2000. Currently, available nutrition data from online sites suggest this beverage contains high amounts of sugar and fat. One published nutrition study suggests that boba tea drinks are part of the larger group of sugar-sweetened beverages (SSB) because these beverages are usually sweetened with high-fructose corn syrup (HFCS)...
January 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/27941940/kefir-peptides-prevent-high-fructose-corn-syrup-induced-non-alcoholic-fatty-liver-disease-in-a-murine-model-by-modulation-of-inflammation-and-the-jak2-signaling-pathway
#11
H L Chen, T C Tsai, Y C Tsai, J W Liao, C C Yen, C M Chen
OBJECTIVE: In recent years, people have changed their eating habits, and high-fructose-containing bubble tea has become very popular. High-fructose intake has been suggested to be a key factor that induces non-alcoholic fatty liver disease (NAFLD). Kefir, a fermented milk product composed of microbial symbionts, has demonstrated numerous biological activities, including antibacterial, antioxidant and immunostimulating effects. The present study aims to evaluate the effects of kefir peptides on high-fructose-induced hepatic steatosis and the possible molecular mechanism...
December 12, 2016: Nutrition & Diabetes
https://www.readbyqxmd.com/read/27892935/the-link-between-soda-intake-and-asthma-science-points-to-the-high-fructose-corn-syrup-not-the-preservatives-a-commentary
#12
L R DeChristopher, J Uribarri, K L Tucker
Recent research conducted by investigators at the National Center for Chronic Disease Prevention and Health Promotion-a division of the US Centers for Disease Control and Prevention (CDC)-found that 'Regular-Soda Intake, Independent of Weight Status, is Associated with Asthma among US High School Students.' On the basis of their review of prior studies, researchers hypothesized that the association may be due to high intake of sodium benzoate, a commonly used preservative in US soft drinks. But a closer look at these prior research studies suggests that there is no strong scientific evidence that the preservatives in US soft drinks are associated with asthma...
November 28, 2016: Nutrition & Diabetes
https://www.readbyqxmd.com/read/27813205/dietary-fructose-induced-hepatocellular-carcinoma-development-manifested-in-mice-lacking-apoptosis-inhibitor-of-macrophage-aim
#13
Takayuki Ozawa, Natsumi Maehara, Toshihiro Kai, Satoko Arai, Toru Miyazaki
The consumption of fructose, including the use of high-fructose corn syrup as a sweetener, has increased continuously in recent decades. Although the involvement of fructose in the development of metabolic diseases has been emphasized recently, whether fructose intake increases susceptibility to steatosis-associated hepatocellular carcinoma (HCC) is unclear. Here, we investigated this issue using mice lacking a circulating protein, apoptosis inhibitor of macrophage (AIM, encoded by cd5l). AIM does not induce carcinogenesis of hepatocytes, but provokes necrotic death specifically in AIM-bound cancer cells through complement cascade activation, thereby preventing HCC tumor development in wild-type mice...
December 2016: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/27774805/-fructose-and-fructose-intolerance
#14
György Miklós Buzás
Although fructose was discovered in 1794, it was realised in recent decades only that its malabsorption can lead to intestinal symptoms while its excessive consumption induces metabolic disturbances. Fructose is a monosaccharide found naturally in most fruits and vegetables. Dietary intake of fructose has gradually increased in the past decades, especially because of the consumption of high fructose corn syrup. With its 16.4 kg/year consumption, Hungary ranks secondly after the United States. Fructose is absorbed in the small intestine by facilitated transport mediated by glucose transporter proteins-2 and -5, and arrives in the liver cells...
October 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27768909/high-fructose-corn-syrup-55-consumption-alters-hepatic-lipid-metabolism-and-promotes-triglyceride-accumulation
#15
Kaitlin Mock, Sundus Lateef, Vagner A Benedito, Janet C Tou
High-fructose corn syrup-55 (HFCS-55) has been suggested to be more lipogenic than sucrose, which increases the risk for nonalcoholic fatty liver disease (NAFLD) and dyslipidemia. The study objectives were to determine the effects of drinking different sugar-sweetened solutions on hepatic gene expression in relation to liver fatty acid composition and risk of NAFLD. Female rats were randomly assigned (n=7 rats/group) to drink water or water sweetened with 13% (w/v) HFCS-55, sucrose or fructose for 8 weeks. Rats drinking HFCS-55 solution had the highest (P=...
January 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27719903/qualitative-and-quantitative-detection-of-honey-adulterated-with-high-fructose-corn-syrup-and-maltose-syrup-by-using-near-infrared-spectroscopy
#16
Shuifang Li, Xin Zhang, Yang Shan, Donglin Su, Qiang Ma, Ruizhi Wen, Jiaojuan Li
Near-infrared spectroscopy (NIR) was used for qualitative and quantitative detection of honey adulterated with high-fructose corn syrup (HFCS) or maltose syrup (MS). Competitive adaptive reweighted sampling (CARS) was employed to select key variables. Partial least squares linear discriminant analysis (PLS-LDA) was adopted to classify the adulterated honey samples. The CARS-PLS-LDA models showed an accuracy of 86.3% (honey vs. adulterated honey with HFCS) and 96.1% (honey vs. adulterated honey with MS), respectively...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27680107/lower-doses-of-fructose-extend-lifespan-in-caenorhabditis-elegans
#17
Jolene Zheng, Chenfei Gao, Mingming Wang, Phuongmai Tran, Nancy Mai, John W Finley, Steven B Heymsfield, Frank L Greenway, Zhaoping Li, David Heber, Jeffrey H Burton, William D Johnson, Roger A Laine
Epidemiological studies indicate that the increased consumption of sugars including sucrose and fructose in beverages correlate with the prevalence of obesity, type-2 diabetes, insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension in humans. A few reports suggest that fructose extends lifespan in Saccharomyces cerevisiae. In Anopheles gambiae, fructose, glucose, or glucose plus fructose also extended lifespan. New results presented here suggest that fructose extends lifespan in Caenorhabditis elegans (C...
May 4, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/27547437/added-sugars-drive-nutrient-and-energy-deficit-in-obesity-a-new-paradigm
#18
REVIEW
James J DiNicolantonio, Amy Berger
Obesity has traditionally been thought of as a state of caloric imbalance, where the intake of calories exceeds the expenditure or 'burning' of calories. However, a more nuanced appreciation for the complex biochemistry and physiology of cellular energy generation suggests that obesity is a state of hormonal imbalance causing increased shunting of food energy into adipose tissue for storage, resulting in decreased satiety and ultimately leading to increased caloric intake. Adding to this hypothesis, we propose that obesity is also a state of nutrient and energy deficit, leading to decreased fatty acid mobilisation and oxidation, the result of which may be a natural disinclination towards physical activity...
2016: Open Heart
https://www.readbyqxmd.com/read/27449852/hypertension-due-to-toxic-white-crystals-in-the-diet-should-we-blame-salt-or-sugar
#19
REVIEW
James J DiNicolantonio, James H O'Keefe
The "Salt Hypothesis" is the notion that an increase in salt intake will increase blood pressure and thus increase the risk of cardiovascular disease (CVD),which has been a point of contention for decades. Despite this, numerous health organizations, dietary guidelines, and government policies advocate population-wide salt restriction. However, there is no conclusive proof that restricting salt intake reduces the risk of hypertension (HTN) and/or CVD events; sodium restriction in fact may paradoxically lead to adverse health outcomes...
November 2016: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/27418186/sugars-obesity-and-cardiovascular-disease-results-from-recent-randomized-control-trials
#20
REVIEW
James M Rippe, Theodore J Angelopoulos
The relationship between sugar consumption and various health-related sequelas is controversial. Some investigators have argued that excessive sugar consumption is associated with increased risk of obesity, coronary heart disease, diabetes (T2D), metabolic syndrome, non-alcoholic fatty liver disease, and stimulation of reward pathways in the brain potentially causing excessive caloric consumption. These concerns have influenced organizations such as the World Health Organization, the Scientific Advisory Committee on Nutrition in England not to exceed 5 % of total energy and the Dietary Guidelines for Americans Advisory Committee 2015 to recommend upper limits of sugar consumption not to exceed 10 % of calories...
November 2016: European Journal of Nutrition
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