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High fructose corn syrup

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https://www.readbyqxmd.com/read/27892935/the-link-between-soda-intake-and-asthma-science-points-to-the-high-fructose-corn-syrup-not-the-preservatives-a-commentary
#1
L R DeChristopher, J Uribarri, K L Tucker
Recent research conducted by investigators at the National Center for Chronic Disease Prevention and Health Promotion-a division of the US Centers for Disease Control and Prevention (CDC)-found that 'Regular-Soda Intake, Independent of Weight Status, is Associated with Asthma among US High School Students.' On the basis of their review of prior studies, researchers hypothesized that the association may be due to high intake of sodium benzoate, a commonly used preservative in US soft drinks. But a closer look at these prior research studies suggests that there is no strong scientific evidence that the preservatives in US soft drinks are associated with asthma...
November 28, 2016: Nutrition & Diabetes
https://www.readbyqxmd.com/read/27813205/dietary-fructose-induced-hepatocellular-carcinoma-development-manifested-in-mice-lacking-apoptosis-inhibitor-of-macrophage-aim
#2
Takayuki Ozawa, Natsumi Maehara, Toshihiro Kai, Satoko Arai, Toru Miyazaki
The consumption of fructose, including the use of high-fructose corn syrup as a sweetener, has increased continuously in recent decades. Although the involvement of fructose in the development of metabolic diseases has been emphasized recently, whether fructose intake increases susceptibility to steatosis-associated hepatocellular carcinoma (HCC) is unclear. Here, we investigated this issue using mice lacking a circulating protein, apoptosis inhibitor of macrophage (AIM, encoded by cd5l). AIM does not induce carcinogenesis of hepatocytes, but provokes necrotic death specifically in AIM-bound cancer cells through complement cascade activation, thereby preventing HCC tumor development in wild-type mice...
November 4, 2016: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/27774805/-fructose-and-fructose-intolerance
#3
György Miklós Buzás
Although fructose was discovered in 1794, it was realised in recent decades only that its malabsorption can lead to intestinal symptoms while its excessive consumption induces metabolic disturbances. Fructose is a monosaccharide found naturally in most fruits and vegetables. Dietary intake of fructose has gradually increased in the past decades, especially because of the consumption of high fructose corn syrup. With its 16.4 kg/year consumption, Hungary ranks secondly after the United States. Fructose is absorbed in the small intestine by facilitated transport mediated by glucose transporter proteins-2 and -5, and arrives in the liver cells...
October 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27768909/high-fructose-corn-syrup-55-consumption-alters-hepatic-lipid-metabolism-and-promotes-triglyceride-accumulation
#4
Kaitlin Mock, Sundus Lateef, Vagner A Benedito, Janet C Tou
High-fructose corn syrup-55 (HFCS-55) has been suggested to be more lipogenic than sucrose, which increases the risk for nonalcoholic fatty liver disease (NAFLD) and dyslipidemia. The study objectives were to determine the effects of drinking different sugar-sweetened solutions on hepatic gene expression in relation to liver fatty acid composition and risk of NAFLD. Female rats were randomly assigned (n=7 rats/group) to drink water or water sweetened with 13% (w/v) HFCS-55, sucrose or fructose for 8 weeks. Rats drinking HFCS-55 solution had the highest (P=...
January 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27719903/qualitative-and-quantitative-detection-of-honey-adulterated-with-high-fructose-corn-syrup-and-maltose-syrup-by-using-near-infrared-spectroscopy
#5
Shuifang Li, Xin Zhang, Yang Shan, Donglin Su, Qiang Ma, Ruizhi Wen, Jiaojuan Li
Near-infrared spectroscopy (NIR) was used for qualitative and quantitative detection of honey adulterated with high-fructose corn syrup (HFCS) or maltose syrup (MS). Competitive adaptive reweighted sampling (CARS) was employed to select key variables. Partial least squares linear discriminant analysis (PLS-LDA) was adopted to classify the adulterated honey samples. The CARS-PLS-LDA models showed an accuracy of 86.3% (honey vs. adulterated honey with HFCS) and 96.1% (honey vs. adulterated honey with MS), respectively...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27680107/lower-doses-of-fructose-extend-lifespan-in-caenorhabditis-elegans
#6
Jolene Zheng, Chenfei Gao, Mingming Wang, Phuongmai Tran, Nancy Mai, John W Finley, Steven B Heymsfield, Frank L Greenway, Zhaoping Li, David Heber, Jeffrey H Burton, William D Johnson, Roger A Laine
Epidemiological studies indicate that the increased consumption of sugars including sucrose and fructose in beverages correlate with the prevalence of obesity, type-2 diabetes, insulin resistance, hyperinsulinemia, hypertriglyceridemia, and hypertension in humans. A few reports suggest that fructose extends lifespan in Saccharomyces cerevisiae. In Anopheles gambiae, fructose, glucose, or glucose plus fructose also extended lifespan. New results presented here suggest that fructose extends lifespan in Caenorhabditis elegans (C...
September 28, 2016: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/27547437/added-sugars-drive-nutrient-and-energy-deficit-in-obesity-a-new-paradigm
#7
REVIEW
James J DiNicolantonio, Amy Berger
Obesity has traditionally been thought of as a state of caloric imbalance, where the intake of calories exceeds the expenditure or 'burning' of calories. However, a more nuanced appreciation for the complex biochemistry and physiology of cellular energy generation suggests that obesity is a state of hormonal imbalance causing increased shunting of food energy into adipose tissue for storage, resulting in decreased satiety and ultimately leading to increased caloric intake. Adding to this hypothesis, we propose that obesity is also a state of nutrient and energy deficit, leading to decreased fatty acid mobilisation and oxidation, the result of which may be a natural disinclination towards physical activity...
2016: Open Heart
https://www.readbyqxmd.com/read/27449852/hypertension-due-to-toxic-white-crystals-in-the-diet-should-we-blame-salt-or-sugar
#8
James J DiNicolantonio, James H O'Keefe
The "Salt Hypothesis" is the notion that an increase in salt intake will increase blood pressure and thus increase the risk of cardiovascular disease (CVD),which has been a point of contention for decades. Despite this, numerous health organizations, dietary guidelines, and government policies advocate population-wide salt restriction. However, there is no conclusive proof that restricting salt intake reduces the risk of hypertension (HTN) and/or CVD events; sodium restriction in fact may paradoxically lead to adverse health outcomes...
July 20, 2016: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/27418186/sugars-obesity-and-cardiovascular-disease-results-from-recent-randomized-control-trials
#9
James M Rippe, Theodore J Angelopoulos
The relationship between sugar consumption and various health-related sequelas is controversial. Some investigators have argued that excessive sugar consumption is associated with increased risk of obesity, coronary heart disease, diabetes (T2D), metabolic syndrome, non-alcoholic fatty liver disease, and stimulation of reward pathways in the brain potentially causing excessive caloric consumption. These concerns have influenced organizations such as the World Health Organization, the Scientific Advisory Committee on Nutrition in England not to exceed 5 % of total energy and the Dietary Guidelines for Americans Advisory Committee 2015 to recommend upper limits of sugar consumption not to exceed 10 % of calories...
July 14, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27357093/no-differential-effect-of-beverages-sweetened-with-fructose-high-fructose-corn-syrup-or-glucose-on-systemic-or-adipose-tissue-inflammation-in-normal-weight-to-obese-adults-a-randomized-controlled-trial
#10
Jessica N Kuzma, Gail Cromer, Derek K Hagman, Kara L Breymeyer, Christian L Roth, Karen E Foster-Schubert, Sarah E Holte, David S Weigle, Mario Kratz
BACKGROUND: Sugar-sweetened beverage (SSB) consumption and low-grade chronic inflammation are both independently associated with type 2 diabetes and cardiovascular disease. Fructose, a major component of SSBs, may acutely trigger inflammation, which may be one link between SSB consumption and cardiometabolic disease. OBJECTIVE: We sought to determine whether beverages sweetened with fructose, high-fructose corn syrup (HFCS), and glucose differentially influence systemic inflammation [fasting plasma C-reactive protein and interleukin-6 (IL-6) as primary endpoints] acutely and before major changes in body weight...
August 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27323620/-effect-of-compound-zhajin-granule-on-toll-like-receptor-4-signaling-pathway-in-nonalcoholic-steatohepatitis-mice
#11
Jing Liu, Zhen-jie Zhuang, Jing Tian, Zhao-yi Li, Yan Luo, Yin-lan Liu, Jian-yu Chen, Xiao-jie Ma, Shu-fei Zang, Jun-ping Shi
OBJECTIVE: To observe the effect of Compound Zhajin Granule (CZG) on Toll-like re-ceptor 4 (TLR4) signaling pathway in high-fructose corn syrup induced NASH mice. METHODS: Thirty 6-week-old male C3H mice were divided into the high fat and high fructose (HFHFr) group (n = 20) and the control group (n = 10) according to body weight. Mice in the HFHFr group ate high fat diet and drank 20% fructose water, while those in the control group ate common diet and drank common water...
April 2016: Chinese Journal of Integrated Traditional and Western Medicine
https://www.readbyqxmd.com/read/27098706/fructose-consumption-impairs-serotonergic-signaling-in-the-murine-enteric-nervous-system
#12
K Lowette, A-S Desmet, R M Farré, J Tack, P Vanden Berghe
The intake of free fructose has increased substantially since the development of high-fructose corn syrup. This has not only been associated with metabolic disorders but recent evidence also indicates that chronic fructose consumption can affect neuronal and cognitive function. In this study we investigated the effects of fructose consumption on serotonergic signaling and neuronal activity in the mouse submucous plexus. Male mice were put on a control or fructose (23% solution) diet for 6 weeks or were assigned to a recovery group that received normal water (2 weeks) after 4 weeks of fructose...
September 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27065156/supplementation-of-glycerol-or-fructose-via-drinking-water-to-enhance-marbling-deposition-and-meat-quality-of-finishing-cattle
#13
Gabriela Volpi-Lagreca, Susan K Duckett
Thirty-six Angus-cross steers (667 ± 34.4 kg initial BW, 24.5 mo) were used to assess the impact of short-term glycerin or high-fructose corn syrup administration via drinking water on meat quality and marbling deposition. Steers blocked by BW (3 blocks) were assigned randomly to 1 of 3 drinking water treatments: 1) control (CON), 2) 4.3% crude glycerin (GLYC), or 3) 4.3% high-fructose corn syrup (HFCS) for the final 25 d before slaughter. Average daily gain was lower ( = 0.01) and final live weight was lower ( < 0...
February 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27042260/effect-of-caffeic-acid-phenethyl-ester-on-vascular-damage-caused-by-consumption-of-high-fructose-corn-syrup-in-rats
#14
Aburrahman Gun, Mehmet Kaya Ozer, Sedat Bilgic, Nevin Kocaman, Gonca Ozan
Fructose corn syrup is cheap sweetener and prolongs the shelf life of products, but fructose intake causes hyperinsulinemia, hypertriglyceridemia, and hypertension. All of them are referred to as metabolic syndrome and they are risk factors for cardiovascular diseases. Hence, the harmful effects of increased fructose intake on health and their prevention should take greater consideration. Caffeic Acid Phenethyl Ester (CAPE) has beneficial effects on metabolic syndrome and vascular function which is important in the prevention of cardiovascular disease...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27039282/trends-in-the-consumption-of-low-calorie-sweeteners
#15
REVIEW
Allison C Sylvetsky, Kristina I Rother
Low-calorie sweeteners (LCS) offer a palatable alternative to caloric sugars such as sucrose (table sugar) and high fructose corn syrup and are commonly found in soft drinks, sweetener packets, grains, snack foods, dairy products, hygiene products, and medications. Consumption of LCS has increased significantly in recent years and while this trend is expected to continue, controversy exists surrounding their use. The purpose of this article is to review trends in the consumption of LCS, to summarize differences in LCS consumption across socio-demographic subgroups and subtypes of LCS-containing products, and to highlight important challenges in the accurate assessment of LCS consumption...
October 1, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27025195/alpha-lipoic-acid-attenuates-high-fructose-induced-pancreatic-toxicity
#16
Senay Topsakal, Ozlem Ozmen, Fatma Nihan Cankara, Sukriye Yesilot, Dilek Bayram, Nilüfer Genç Özdamar, Sümeyra Kayan
OBJECTIVES: Chronic consumption of high-fructose corn syrup (HFCS) causes several problems such as insulin resistance. The goal of the study was to investigate pancreatic damage induced by chronic HFCS consumption and the protective effects of alpha lipoic acid (ALA) on pancreatic cells. METHODS: Wistar Albino, 4-month-old, female rats weighing 250-300 g were randomly distributed into three groups, each containing eight rats. The study included an HFCS group, an HFCS + ALA-administered group and a control group (CON)...
May 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27023594/fructose-containing-sugars-at-normal-levels-of-consumption-do-not-effect-adversely-components-of-the-metabolic-syndrome-and-risk-factors-for-cardiovascular-disease
#17
Theodore J Angelopoulos, Joshua Lowndes, Stephanie Sinnett, James M Rippe
The objective of the current study was to explore our hypothesis that average consumption of fructose and fructose containing sugars would not increase risk factors for cardiovascular disease (CVD) and the metabolic syndrome (MetS). A randomized, double blind, parallel group study was conducted where 267 individuals with BMI between 23 and 35 kg/m² consumed low fat sugar sweetened milk, daily for ten weeks as part of usual weight-maintenance diet. One group consumed 18% of calories from high fructose corn syrup (HFCS), another group consumed 18% of calories from sucrose, a third group consumed 9% of calories from fructose, and the fourth group consumed 9% of calories from glucose...
March 23, 2016: Nutrients
https://www.readbyqxmd.com/read/27001645/physiological-handling-of-dietary-fructose-containing-sugars-implications-for-health
#18
REVIEW
V C Campos, L Tappy
Fructose has always been present in our diet, but its consumption has increased markedly over the past 200 years. This is mainly due to consumption of sucrose or high-fructose corn syrup in industrial foods and beverages. Unlike glucose, fructose cannot be directly used as an energy source by all cells of the human body and needs first to be converted into glucose, lactate or fatty acids in the liver, intestine and kidney. Because of this specific two-step metabolism, some energy is consumed in splanchnic organs to convert fructose into other substrates, resulting in a lower net energy efficiency of fructose compared with glucose...
March 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27001643/added-sugars-and-risk-factors-for-obesity-diabetes-and-heart-disease
#19
REVIEW
J M Rippe, T J Angelopoulos
The effects of added sugars on various chronic conditions are highly controversial. Some investigators have argued that added sugars increase the risk of obesity, diabetes and cardiovascular disease. However, few randomized controlled trials are available to support these assertions. The literature is further complicated by animal studies, as well as studies which compare pure fructose to pure glucose (neither of which is consumed to any appreciable degree in the human diet) and studies where large doses of added sugars beyond normal levels of human consumption have been administered...
March 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/26950480/intake-of-high-fructose-corn-syrup-sweetened-soft-drinks-fruit-drinks-and-apple-juice-is-associated-with-prevalent-arthritis-in-us-adults-aged-20-30-years
#20
L R DeChristopher, J Uribarri, K L Tucker
OBJECTIVE: There is a link between joint and gut inflammation of unknown etiology in arthritis. Existing research indicates that regular consumption of high-fructose corn syrup sweetened (HFCS) soft drinks, but not diet soft drinks, may be associated with increased risk of seropositive rheumatoid arthritis (RA) in women, independent of other dietary and lifestyle factors. One unexplored hypothesis for this association is that fructose malabsorption, due to regular consumption of excess free fructose (EFF) and HFCS, contributes to fructose reactivity in the gastrointestinal tract and intestinal in situ formation of enFruAGEs, which once absorbed, travel beyond the intestinal boundaries to other tissues and promote inflammation...
2016: Nutrition & Diabetes
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