Yoshitaka Ando, Eiji Munetsuna, Hiroya Yamada, Miyuki Ikeya, Atsushi Teshigawara, Itsuki Kageyama, Yuki Nouchi, Takuya Wakasugi, Mirai Yamazaki, Genki Mizuno, Yoshiki Tsuboi, Hiroaki Ishikawa, Nobutaka Ohgami, Koji Suzuki, Koji Ohashi
AIMS: The developmental origin of health and disease (DOHaD) theory postulates that poor nutrition during fetal life increases the risk of disease later in life. Excessive fructose intake has been associated with obesity, diabetes, and nonalcoholic fatty liver disease, and maternal fructose intake during pregnancy has been shown to affect offspring health. In this study, we investigated the effects of high maternal fructose intake on the liver stem/progenitor cells of offspring. MAIN METHOD: A fructose-based DOHaD model was established using Sprague-Dawley rats...
November 28, 2023: Life Sciences