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https://www.readbyqxmd.com/read/29679874/development-of-an-hplc-uv-method-for-the-evaluation-of-extractables-and-leachables-in-plastic-application-to-a-plastic-packaged-calcium-gluconate-glucoheptonate-solution
#1
Pauline Legrand, Anne Desdion, Gaétan Boccadifuoco, Amélie Dufaÿ Wojcicki, Alan Worsley, Vincent Boudy, Sophie Goulay Dufay
Calcium gluconate glucoheptonate (GGCa) is known to interact with glass containers, leading to the leaching of aluminum from the glass into the solution at toxic level. Therefore, plastic containers seem to be a preferable packaging alternative. Nevertheless, plastics contain potentially toxic additives which could be released into the solution. In order to study content container interaction between GGCa and two plastic containers (polypropylene PP and polyethylene PE containers), an HPLC-PDA method was developed to separate, detect and quantify eleven additives commonly found in plastic materials, with good limit of detection and quantification...
March 21, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29679849/global-analysis-of-advanced-metastatic-breast-cancer-decade-report-2005-2015
#2
Fatima Cardoso, Danielle Spence, Shirley Mertz, Dian Corneliussen-James, Kimberly Sabelko, Julie Gralow, Maria-João Cardoso, Fedro Peccatori, Diego Paonessa, Ann Benares, Naomi Sakurai, Marc Beishon, Sarah-Jane Barker, Musa Mayer
Approximately 0.5 million people worldwide die from metastatic breast cancer (mBC) every year. This manuscript provides an overview on the status of mBC in several regions of the world, highlighting the gaps in care, resources, and support available for patients with mBC. Primary research was conducted in 2015 and 2016, comprising four global qualitative and quantitative surveys of approximately 15,000 individuals in 34 countries. Secondary research was conducted using literature reviews of peer-reviewed publications, patient survey reports, and media or online articles...
April 18, 2018: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29679815/dual-docking-robotic-surgical-staging-for-high-risk-endometrial-cancer
#3
Cécile Loaec, Anne-Sophie Bats, Charlotte Ngo, Caroline Cornou, Léa Rossi, Chérazade Bensaid, Claude Nos, Fabrice Lecuru
OBJECTIVE: The standard of care for patients with high intermediate and high risk endometrial cancer is surgical staging including total hysterectomy with bilateral salpingo-oophorectomy, and pelvic and para-aortic lymphadenectomy. Over the past decade, laparoscopic or robot-assisted minimally invasive surgery has showed many benefits in the management of endometrial cancer. Few studies have specifically assessed the use of minimally invasive surgery for staging of high risk endometrial cancer...
April 16, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29679774/comparable-results-of-autologous-and-allogeneic-haematopoietic-stem-cell-transplantation-for-adults-with-philadelphia-positive-acute-lymphoblastic-leukaemia-in-first-complete-molecular-remission-an-analysis-by-the-acute-leukemia-working-party-of-the-ebmt
#4
Sebastian Giebel, Myriam Labopin, Michael Potter, Xavier Poiré, Henrik Sengeloev, Gerard Socié, Anne Huynh, Boris V Afanasyev, Urs Schanz, Olle Ringden, Peter Kalhs, Dietrich W Beelen, Antonio M Campos, Tamás Masszi, Jonathan Canaani, Mohamad Mohty, Arnon Nagler
BACKGROUND: Allogeneic haematopoietic stem cell transplantation (alloHSCT) is considered a standard treatment for patients with Philadelphia chromosome-positive acute lymphoblastic leukaemia (Ph+ ALL) achieving complete remission after induction containing tyrosine kinase inhibitors (TKIs). METHODS: We retrospectively compared results of myeloablative alloHSCT from either matched sibling donor (MSD) or unrelated donor (URD) with autologous (auto) HSCT for adults with Ph+ ALL in molecular remission, treated between 2007 and 2014...
April 18, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29679704/a-separable-two-dimensional-random-field-model-of-binary-response-data-from-multi-day-behavioral-experiments
#5
Noa Malem-Shinitski, Yingzhuo Zhang, Daniel T Gray, Sara N Burke, Anne C Smith, Carol A Barnes, Demba Ba
BACKGROUND: The study of learning in populations of subjects can provide insights into the changes that occur in the brain with aging, drug intervention, and psychiatric disease. NEW METHOD: We introduce a separable two-dimensional (2D) random field (RF) model for analyzing binary response data acquired during the learning of object-reward associations across multiple days. The method can quantify the variability of performance within a day and across days, and can capture abrupt changes in learning...
April 18, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29679690/reduced-body-weight-or-increased-muscle-quality-which-is-more-important-for-improving-physical-function-following-exercise-and-weight-loss-in-overweight-and-obese-older-women
#6
Chad R Straight, Alison C Berg, Rachelle A Reed, Mary Ann Johnson, Ellen M Evans
The purpose of this study was to examine the relative contributions of changes in muscle quality and body composition to changes in lower-extremity physical function (LEPF) following a 6-month exercise and weight loss intervention in overweight and obese older women. Thirty-eight overweight and obese (BMI = 30.0 ± 4.4 kg/m2 ) older (age = 69.3 ± 4.1 y) women completed 6 months of multicomponent exercise (cardiorespiratory, resistance, balance and flexibility training) and weight loss (hypocaloric diet that reduced energy intake by ~500 kcal/d)...
April 18, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29679658/effective-multicomponent-interventions-in-comparison-to-active-control-and-no-interventions-on-physical-capacity-cognitive-function-and-instrumental-activities-of-daily-living-in-elderly-people-with-and-without-mild-impaired-cognition-a-systematic-review-and
#7
REVIEW
Marina Bruderer-Hofstetter, Anne-Kathrin Rausch-Osthoff, André Meichtry, Thomas Münzer, Karin Niedermann
Multicomponent interventions (MCT) combine physical exercises and cognitive training and seem to be most effective in improving cognition in elderly people. However, literature is inconclusive if MCTs are superior to active comparison interventions, if delivery modes matter, and if people can transfer achieved effects to instrumental activities of daily living (IADL). This network meta-analysis aimed to a) identify MCTs that were effective on physical capacity and/or cognitive function and able to transfer these effects into IADL in elderly people with normal cognition (NC) and mild cognitive impairment (MCI); b) provide a rating on the best interventions per outcome; c) evaluate MCTs' mode of delivery...
April 18, 2018: Ageing Research Reviews
https://www.readbyqxmd.com/read/29679529/influence-of-human-milk-and-parenteral-lipid-emulsions-on-serum-fatty-acid-profiles-in-extremely-preterm-infants
#8
Anders K Nilsson, Chatarina Löfqvist, Svetlana Najm, Gunnel Hellgren, Karin Sävman, Mats X Andersson, Lois E H Smith, Ann Hellström
BACKGROUND: Infants born prematurely are at risk of a deficiency in ω-6 and ω-3 long-chain polyunsaturated fatty acids (LC-PUFAs) arachidonic acid (AA) and docosahexaenoic acid (DHA). We investigated how fatty acids from breast milk and parenteral lipid emulsions shape serum LC-PUFA profiles in extremely preterm infants during early perinatal life. METHODS: Ninety infants born < 28 weeks gestational age were randomized to receive parenteral lipids with or without the ω-3 LC-PUFAs eicosapentaenoic acid (EPA) and DHA (SMOFlipid: Fresenius Kabi, Uppsala, Sweden, or Clinoleic: Baxter Medical AB, Kista, Sweden, respectively)...
April 21, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29679502/new-paradigms-in-adenosine-receptor-pharmacology-allostery-oligomerization-and-biased-agonism
#9
REVIEW
Elizabeth A Vecchio, Jo-Anne Baltos, Anh T N Nguyen, Arthur Christopoulos, Paul J White, Lauren T May
Adenosine receptors (ARs) are a family of G protein-coupled receptors (GPCRs) containing four subtypes (A1 AR, A2A AR, A2B AR and A3 AR), all of which bind the ubiquitous nucleoside adenosine. ARs play an important role in physiology and pathophysiology and therefore represent attractive drug targets for a range of conditions. The theoretical framework surrounding AR drug action now extends beyond the notion of prototypical agonism and antagonism to encompass more complex pharmacological concepts. New paradigms include allostery, whereby ligands bind a topographically distinct receptor site from that of the endogenous agonist, homomeric or heteromeric interactions across receptor oligomers and biased agonism; that is, ligand-dependent differential intracellular signalling...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679497/ewsr1-patz1-gene-fusion-may-define-a-new-glioneuronal-tumor-entity
#10
Aurore Siegfried, Audrey Rousseau, Claude-Alain Maurage, Sarah Pericart, Yvan Nicaise, Frederic Escudie, David Grand, Alix Delrieu, Anne Gomez-Brouchet, Sophie Le Guellec, Camille Franchet, Sergio Boetto, Matthieu Vinchon, Jean-Christophe Sol, Franck-Emmanuel Roux, Valerie Rigau, Anne-Isabelle Bertozzi, David Tw Jones, Dominique Figarella-Branger, Emmanuelle Uro-Coste
We investigated the challenging diagnostic case of a ventricular cystic glioneuronal tumor with papillary features, by RNA sequencing using the Illumina TruSight RNA Fusion panel. We did not retrieve the SLC44A1-PRKCA fusion gene specific for papillary glioneuronal tumor, but an EWSR1-PATZ1 fusion transcript. RT-PCR followed by Sanger sequencing confirmed the EWSR1-PATZ1 fusion. It matched with canonic EWSR1 fusion oncogene, juxtaposing the entire N terminal transcriptional activation domain of EWSR1 gene and the C terminal DNA binding domain of a transcription factor gene, PATZ1...
April 21, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29679388/somatic-slc35a2-variants-in-the-brain-are-associated-with-intractable-neocortical-epilepsy
#11
Melodie R Winawer, Nicole G Griffin, Jorge Samanamud, Evan H Baugh, Dinesh Rathakrishnan, Senthilmurugan Ramalingam, David Zagzag, Catherine A Schevon, Patricia Dugan, Manu Hegde, Sameer A Sheth, Guy M McKhann, Werner K Doyle, Gerald A Grant, Brenda E Porter, Mohamad A Mikati, Carrie R Muh, Colin D Malone, Ann Marie R Bergin, Jurriaan M Peters, Danielle K McBrian, Alison M Pack, Cigdem I Akman, Christopher M LaCoursiere, Katherine M Keever, Joseph R Madsen, Edward Yang, Hart G W Lidov, Catherine Shain, Andrew S Allen, Peter Canoll, Peter B Crino, Annapurna H Poduri, Erin L Heinzen
OBJECTIVE Somatic variants are a recognized cause of epilepsy-associated focal malformations of cortical development (MCD). We hypothesized that somatic variants may underlie a wider range of focal epilepsy, including non-lesional focal epilepsy (NLFE). Through genetic analysis of brain tissue, we evaluated the role of somatic variation in focal epilepsy with and without MCD. METHODS We identified somatic variants through high-depth exome and ultra-high-depth candidate gene sequencing of DNA from epilepsy surgery specimens and leukocytes from 18 individuals with NLFE and 38 with focal MCD...
April 20, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29679287/the-first-ms-cleavable-photo-thiol-reactive-cross-linker-for-protein-structural-studies
#12
Claudio Iacobucci, Christine Piotrowski, Anne Rehkamp, Christian H Ihling, Andrea Sinz
Cleavable cross-linkers are gaining increasing importance for chemical cross-linking/mass spectrometry (MS) as they permit a reliable and automated data analysis in structural studies of proteins and protein assemblies. Here, we introduce 1,3-diallylurea (DAU) as the first CID-MS/MS-cleavable, photo-thiol-reactive cross-linker. DAU is a commercially available, inexpensive reagent that efficiently undergoes an anti-Markovnikov hydrothiolation with cysteine residues in the presence of a radical initiator upon UV-A irradiation...
April 20, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29679264/technology-focused-family-interventions-in-pediatric-chronic-illness-a-systematic-review
#13
REVIEW
Kimberly S Canter, Jennifer Christofferson, Michele A Scialla, Anne E Kazak
This systematic review provides a synthesis of randomized-controlled trials of technology-focused family interventions for children with chronic illnesses and their families, focused on describing the current state of the literature and generating recommendations for future family systems work in the field of eHealth/mHealth. Twenty-three studies met inclusion criteria and were included in the systematic review. No identified studies featured an mHealth delivery modality. Relevant data were extracted and studies were assessed for quality...
April 20, 2018: Journal of Clinical Psychology in Medical Settings
https://www.readbyqxmd.com/read/29679160/lasvm-based-big-data-learning-system-for-dynamic-prediction-of-air-pollution-in-tehran
#14
Z Ghaemi, A Alimohammadi, M Farnaghi
Due to critical impacts of air pollution, prediction and monitoring of air quality in urban areas are important tasks. However, because of the dynamic nature and high spatio-temporal variability, prediction of the air pollutant concentrations is a complex spatio-temporal problem. Distribution of pollutant concentration is influenced by various factors such as the historical pollution data and weather conditions. Conventional methods such as the support vector machine (SVM) or artificial neural networks (ANN) show some deficiencies when huge amount of streaming data have to be analyzed for urban air pollution prediction...
April 20, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29679157/immediate-release-3d-printed-tablets-produced-via-fused-deposition-modeling-of-a-thermo-sensitive-drug
#15
Wiebke Kempin, Vanessa Domsta, Georg Grathoff, Iris Brecht, Beatrice Semmling, Susan Tillmann, Werner Weitschies, Anne Seidlitz
PURPOSE: Dissolution speeds of tablets printed via Fused Deposition Modeling (FDM) so far are significantly lower compared to powder or granule pressed immediate release tablets. The aim of this work was to print an actual immediate release tablet by choosing suitable polymers and printing designs, also taking into account lower processing temperatures (below 100°C) owing to the used model drug pantoprazole sodium. METHODS: Five different pharmaceutical grade polymers polyvinylpyrrolidone (PVP K12), polyethylene glycol 6000 (PEG 6000), Kollidon® VA64, polyethylene glycol 20,000 (PEG 20,000) and poloxamer 407 were successfully hot-melt-extruded to drug loaded filaments and printed to tablets at the required low temperatures...
April 20, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29679118/welcome-new-associate-editors-sandra-wong-and-cheng-har-yip-to-the-world-journal-of-surgery
#16
EDITORIAL
Julie Ann Sosa
No abstract text is available yet for this article.
April 20, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29679112/post-treatment-positron-emission-tomography-computed-tomography-is-highly-predictive-of-outcome-in-plasmablastic-lymphoma
#17
Yassine Al Tabaa, Emmanuelle Tchernonog, Pierre Faurie, Anne Ségolène Cottereau, Hélène Monjanel, Antoine Bonnet, Steven Le Gouill, Emmanuel Gyan, Hervé Ghesquieres, Denis Mariano-Goulart, Guillaume Cartron
PURPOSE: Plasmablastic lymphoma (PBL) is a rare variant of diffuse large B cell lymphomas (DLBCL) clinically characterized by a poorer prognostic. Few clinical and imaging data are available and derived from pooled case reports and small series. The aim of the study was to evaluate the FDG avidity at baseline and the utility of 18-Fluorodeoxyglucose (FDG) positron-emission-tomography/computed-tomography (PET/CT) for staging and response assessment. METHODS: Patients with newly diagnosed PBL seen at Lymphoma Study Association centers during the period 2005-2015 were included if they underwent a PET/CT at staging and at the end of treatment (eotPET) and had received an anthracycline-based first line therapy...
April 20, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29679105/the-practices-of-french-general-practitioners-regarding-screening-and-counselling-pregnant-women-for-tobacco-smoking-and-alcohol-drinking
#18
Raphaël Andler, Chloé Cogordan, Anne Pasquereau, Jean-François Buyck, Viêt Nguyen-Thanh
OBJECTIVES: Our study aims to describe French general practitioners' (GPs') practices toward pregnant patients regarding alcohol consumption and smoking and to highlight factors associated with specific practices. METHODS: In 2015, a representative sample of 1414 French GPs completed a telephone survey based on a stratified random sampling. RESULTS: 61% of GPs declared screening for alcohol use and 82% for smoking at least once with each pregnant patient; quitting was not systematically advised either for alcohol or for smoking...
April 20, 2018: International Journal of Public Health
https://www.readbyqxmd.com/read/29679099/radiation-induced-carotid-artery-lesions
#19
REVIEW
Verónica Fernández-Alvarez, Fernando López, Carlos Suárez, Primoz Strojan, Avraham Eisbruch, Carl E Silver, William M Mendenhall, Johannes A Langendijk, Alessandra Rinaldo, Anne W M Lee, Jonathan J Beitler, Robert Smee, Javier Alvarez, Alfio Ferlito
PURPOSE: To review the current aspects of knowledge related to the risk of cerebrovascular events in patients receiving head and neck radiotherapy. METHODS: A literature search was performed in PubMed. Papers meeting selection criteria were reviewed. RESULTS: We provide an update on the problem by identifying key studies that have contributed to our current understanding of the epidemiology, radiologic features, pathogenesis, and treatment of the disease...
April 20, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29679089/general-practitioner-s-attitudes-and-confidence-in-managing-patients-with-dementia-in-singapore
#20
Mythily Subramaniam, Hui Lin Ong, Edimansyah Abdin, Boon Yiang Chua, Saleha Shafie, Fiona Devi Siva Kumar, Sophia Foo, Li Ling Ng, Alvin Lum, Janhavi A Vaingankar, Siow Ann Chong
The number of people living with dementia is increasing globally as a result of an ageing population. General practitioners (GPs), as the front-line care providers in communities, are important stakeholders in the system of care for people with dementia. This commentary describes a study conducted to understand GPs' attitudes and self-perceived competencies when dealing with patients with dementia and their caregivers in Singapore. A set of study information sheet and survey questionnaires were mailed to selected GP clinics in Singapore...
March 2018: Annals of the Academy of Medicine, Singapore
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