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https://www.readbyqxmd.com/read/29245110/uncovering-the-mysteries-of-inclusion-empirical-and-methodological-possibilities-in-participatory-evaluation-in-an-international-context
#1
Jill Anne Chouinard, Peter Milley
The inclusion of stakeholders in participatory evaluation in highly diverse, culturally complex settings remains a challenge, given issues of inequity, power, voice, capacity and skill. These challenges are well documented, but there is a relative absence of papers devoted to addressing them based on examples and evidence. In this paper, we report our review of 51 empirical studies of participatory evaluations conducted in the international domain, focusing on the methods of inclusion used in the evaluations...
December 8, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29245061/risk-and-prognosis-of-cancer-after-upper-extremity-deep-venous-thrombosis-a-population-based-cohort-study
#2
Kasper Adelborg, Erzsébet Horváth-Puhó, Jens Sundbøll, Paolo Prandoni, Anne Ording, Henrik Toft Sørensen
INTRODUCTION: The association between lower-extremity venous thrombosis and cancer is well-established. However, the extent to which upper-extremity deep venous thrombosis (U-DVT) is a marker of cancer and a prognostic factor for all-cause mortality remains poorly understood. We examined the risk of cancer after a diagnosis of U-DVT compared with cancer risk in the general population. MATERIALS AND METHODS: Using Danish nationwide population-based medical registries, we identified all patients with first-time U-DVT during 1980-1993 and 2000-2013...
November 22, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/29244822/alcohol-consumption-and-breast-cancer-specific-and-all-cause-mortality-in-women-diagnosed-with-breast-cancer-at-the-new-york-site-of-the-breast-cancer-family-registry
#3
Nur Zeinomar, Ashley Thai, Ann J Cloud, Jasmine A McDonald, Yuyan Liao, Mary Beth Terry
PURPOSE: Alcohol consumption is an established and important risk factor for breast cancer incidence in the general population. However, the relationship between alcohol and mortality among women with breast cancer is less clear. This study examines the effect of alcohol consumption on mortality in women affected with breast cancer at baseline from a high-risk family breast and ovarian cancer registry. METHODS: We studied 1116 women affected with breast cancer at baseline from the Metropolitan New York Registry...
2017: PloS One
https://www.readbyqxmd.com/read/29244245/substance-p-in-dorsal-root-ganglion-neurons-in-young-and-adult-rats-after-nociceptive-stimulation-during-the-neonatal-period
#4
Ana Leda Bertoncini Simões, Greice Anne Rodrigues Silva, Carolina Giorgetto, Elisabete de Cassia do Carmo-Campos, Fernando José Dias, Valéria Paula Sassoli Fazan
The nervous system is highly plastic during the neonatal period, being sensitive to noxious stimuli, which may cause short- and long-term pain responsivity changes. Understanding plasticity in peripheral pain pathways is crucial, particularly when the nervous system is still under development and remodeling process. Substance P (SP) is widely used as a marker for peripheral neurons with unmyelinated and small myelinated fibers. We investigated the number of SP immunoreactive neurons in the dorsal root ganglion (DRG) of male and female Wistar rats, 15 and 180 days after nociceptive stimulation during the neonatal period...
December 15, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29244187/polycytidylation-of-mitochondrial-mrnas-in-chlamydomonas-reinhardtii
#5
Thalia Salinas-Giegé, Marina Cavaiuolo, Valérie Cognat, Elodie Ubrig, Claire Remacle, Anne-Marie Duchêne, Olivier Vallon, Laurence Maréchal-Drouard
The unicellular photosynthetic organism, Chlamydomonas reinhardtii, represents a powerful model to study mitochondrial gene expression. Here, we show that the 5'- and 3'-extremities of the eight Chlamydomonas mitochondrial mRNAs present two unusual characteristics. First, all mRNAs start primarily at the AUG initiation codon of the coding sequence which is often marked by a cluster of small RNAs. Second, unusual tails are added post-transcriptionally at the 3'-extremity of all mRNAs. The nucleotide composition of the tails is distinct from that described in any other systems and can be partitioned between A/U-rich tails, predominantly composed of Adenosine and Uridine, and C-rich tails composed mostly of Cytidine...
December 15, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29244143/impact-of-hiv-1-minority-variants-on-the-virus-response-to-a-rilpivirine-based-first-line-regimen
#6
Stéphanie Raymond, Florence Nicot, Coralie Pallier, Pantxika Bellecave, Anne Maillard, Mary Anne Trabaud, Laurence Morand-Joubert, Audrey Rodallec, Corinne Amiel, Thomas Mourez, Laurence Bocket, Agnès Beby-Defaux, Magali Bouvier-Alias, Sidonie Lambert-Niclot, Charlotte Charpentier, Brice Malve, Audrey Mirand, Julia Dina, Hélène Le Guillou-Guillemette, Stéphanie Marque-Juillet, Anne Signori-Schmuck, Francis Barin, Ali Si-Mohamed, Véronique Avettand Fenoel, Catherine Roussel, Vincent Calvez, Karine Saune, Anne Geneviève Marcelin, Christophe Rodriguez, Diane Descamps, Jacques Izopet
Background: Minority resistant variants of HIV-1 could influence the virological response to treatment based on non-nucleoside reverse transcriptase (RT) inhibitors. Data on minority rilpivirine-resistant variants are scarce. This study used next-generation sequencing (NGS) to identify patients harbouring minority resistant variants to nucleos(t)ide and non-nucleoside RT inhibitors and to assess their influence on the virological response (VR). Methods: All the subjects, 541 HIV-1-infected patients being treated at 24 French virology laboratories, started their first line regimen containing rilpivirine between 2012 and 2015...
December 13, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29244090/prevalence-and-risk-of-severe-cognitive-impairment-in-advanced-chronic-kidney-disease
#7
Christine M Burns, David S Knopman, David E Tupper, Cynthia S Davey, Yelena M Slinin, Kamakshi Lakshminarayan, Rebecca C Rossom, Sarah L Pederson, David T Gilbertson, Anne M Murray
Background: Our primary goal is to describe the prevalence, severity, and risk of cognitive impairment (CI) by estimated glomerular filtration rate (eGFR, in ml/min/1.73 m 2) in a cohort enriched for advanced CKD (eGFR < 45), adjusting for albuminuria, as measured by urine albumin-to-creatinine ratio (UACR, in mg/g). As both eGFR and albuminuria are associated with CI risk in CKD, we also seek to determine the extent that eGFR remains a useful biomarker for risk of CI in those with CKD and concomitant albuminuria...
December 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29244086/cerebral-blood-flow-changes-after-radiation-therapy-identifies-pseudo-progression-in-diffuse-intrinsic-pontine-gliomas
#8
Raphael Calmon, Stephanie Puget, Pascale Varlet, Volodia Dangouloff-Ros, Thomas Blauwblomme, Kevin Beccaria, David Grevent, Christian Sainte-Rose, David Castel, Marie-Anne Debily, Christelle Dufour, Stéphanie Bolle, Frederic Dhermain, Ana Saitovitch, Monica Zilbovicius, Francis Brunelle, Jacques Grill, Nathalie Boddaert
Background: The interval between progression and death in diffuse intrinsic pontine glioma (DIPG) is usually < 6 months. However, reports of longer patient survival following radiotherapy, in the presence of radiological signs of progression, suggest that these cases may be comparable to pseudo-progression observed in adult glioblastoma. Our aim was to identify such cases and compare their multimodal MRI features with those of patients that did not present the same evolution. Methods: Multimodal MRI of 43 children treated for DIPG were retrospectively selected at four time points: baseline, after-radiotherapy, during true-progression, and at the last-visit...
December 13, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29244042/feasibility-and-effects-of-a-nursing-intervention-for-patients-with-peripheral-vestibular-disorders
#9
Carina Faag, Johan Bergenius, Christina Forsberg, Ann Langius-Eklöf
PURPOSE: To explore the feasibility and possible outcomes of a nursing intervention in patients with peripheral vestibular disorders. DESIGN: A randomized controlled trial (RCT). METHODS: Thirty-six patients participated in the study: the intervention group (n = 18), who received the intervention, and patients in a control group (n = 18), who received standard care. The intervention includes patient education and individualized nursing support during a 6-month rehabilitation period...
September 2017: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29243975/erratum
#10
Efthimia Lioliou, Pierre Fechter, Isabelle Caldelari, Brian C Jester, Sarah Dubrac, Anne-Catherine Helfer, Sandrine Boisset, François Vandenesch, Pascale Romby, Thomas Geissmann
No abstract text is available yet for this article.
December 2, 2017: RNA Biology
https://www.readbyqxmd.com/read/29243974/pediatric-cerebral-venous-sinus-thrombosis-or-compression-in-the-setting-of-skull-fractures-from-blunt-head-trauma
#11
David S Hersh, Nir Shimony, Mari L Groves, Gerald F Tuite, George I Jallo, Ann Liu, Tomas Garzon-Muvdi, Thierry A G M Huisman, Ryan J Felling, Joseph A Kufera, Edward S Ahn
OBJECTIVE Pediatric cerebral venous sinus thrombosis has been previously described in the setting of blunt head trauma; however, the population demographics, risk factors for thrombosis, and the risks and benefits of detection and treatment in this patient population are poorly defined. Furthermore, few reports differentiate between different forms of sinus pathology. A series of pediatric patients with skull fractures who underwent venous imaging and were diagnosed with intrinsic cerebral venous sinus thrombosis or extrinsic sinus compression is presented...
December 15, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29243878/predictive-value-of-c-reactive-protein-for-tuberculosis-bloodstream-infection-or-death-among-hiv-infected-individuals-with-chronic-non-specific-symptoms-and-negative-sputum-smear-microscopy
#12
Richard A Bedell, Monique van Lettow, Christopher Meaney, Elizabeth L Corbett, Adrienne K Chan, Robert S Heyderman, Suzanne T Anderson, Ann Åkesson, Moses Kumwenda, Rony Zachariah, Anthony D Harries, Andrew R Ramsay
BACKGROUND: To determine whether C-reactive protein (CRP) is an inflammatory biomarker that may identify patients at risk of infections or death. Mortality among HIV-infected persons commencing antiretroviral therapy (ART) is often attributed to tuberculosis (TB) or bloodstream infections (BSI). METHODS: In two district hospitals in southern Malawi we recruited HIV-infected adults with one or more unexplained symptoms present for at least one month (weight loss, fever, or diarrhea), and negative expectorated sputum microscopy for TB...
December 15, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29243816/two-decades-of-persisting-income-disparities-in-dental-caries-among-u-s-children-and-adolescents
#13
Gary Douglas Slade, Anne Elizabeth Sanders
OBJECTIVE: To describe trends in income disparities in dental caries among U.S. children and adolescents during two decades of fluctuating economic growth. METHODS: Data were from National Health and Nutrition Examination Surveys conducted in 1988-1994, 1999-2004, and 2011-2014. The number of tooth surfaces with dental caries experience per child was computed for three age groups: 2-5, 6-11, and 12-17 years. Absolute and relative measures of inequality compared caries experience in families below the poverty level with families where income was at least three times the poverty threshold...
December 15, 2017: Journal of Public Health Dentistry
https://www.readbyqxmd.com/read/29243485/molecular-imaging-of-prostate-cancer
#14
Anne Marie Boustani, Darko Pucar, Lawrence Saperstein
Prostate cancer is a common malignancy with various treatments from surveillance, surgery, radiation and chemotherapy. The institution of appropriate, effective treatment relies in part on accurate imaging. Molecular imaging techniques offer an opportunity for increased timely detection of prostate cancer, its recurrence, as well as metastatic disease. Advancements within the field of molecular imaging have been complex with some agents targeting receptors and others acting as metabolic intermediaries. In this article, we provide an overview of the most clinically relevant radiotracers to date based on a combination of the 5 states model and the National Comprehensive Cancer Network (NCCN) Guidelines...
December 15, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29243415/compact-dual-mode-diffuse-optical-system-for-blood-perfusion-monitoring-in-a-porcine-model-of-microvascular-tissue-flaps
#15
Seung Yup Lee, Julia M Pakela, Michael C Helton, Karthik Vishwanath, Yooree G Chung, Noah J Kolodziejski, Christopher J Stapels, Daniel R McAdams, Daniel E Fernandez, James F Christian, Jameson O'Reilly, Dana Farkas, Brent B Ward, Stephen E Feinberg, Mary-Ann Mycek
In reconstructive surgery, the ability to detect blood flow interruptions to grafted tissue represents a critical step in preventing postsurgical complications. We have developed and pilot tested a compact, fiber-based device that combines two complimentary modalities-diffuse correlation spectroscopy (DCS) and diffuse reflectance spectroscopy-to quantitatively monitor blood perfusion. We present a proof-of-concept study on an in vivo porcine model (n=8). With a controllable arterial blood flow supply, occlusion studies (n=4) were performed on surgically isolated free flaps while the device simultaneously monitored blood flow through the supplying artery as well as flap perfusion from three orientations: the distal side of the flap and two transdermal channels...
December 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29243370/neurological-nutritional-and-alcohol-consumption-factors-underlie-cognitive-and-motor-deficits-in-chronic-alcoholism
#16
Rosemary Fama, Anne-Pascale Le Berre, Cheshire Hardcastle, Stephanie A Sassoon, Adolf Pfefferbaum, Edith V Sullivan, Natalie M Zahr
Variations in pattern and extent of cognitive and motor impairment occur in alcoholism (ALC). Causes of such heterogeneity are elusive and inconsistently accounted for by demographic or alcohol consumption differences. We examined neurological and nutritional factors as possible contributors to heterogeneity in impairment. Participants with ALC (n = 96) and a normal comparison group (n = 41) were examined on six cognitive and motor domains. Signs of historically determined subclinical Wernicke's encephalopathy were detected using the Caine et al...
December 15, 2017: Addiction Biology
https://www.readbyqxmd.com/read/29243344/intensive-care-survivor-reported-symptoms-a-longitudinal-study-of-survivors-symptoms
#17
Anne Kathrine Langerud, Tone Rustøen, Milaancarova Småstuen, Ulf Kongsgaard, Audun Stubhaug
BACKGROUND: There is growing interest in potential long-term outcomes following intensive care, but few researchers have studied the prevalence of multiple symptoms or the association between pain and other symptoms. AIMS: To investigate the prevalence of anxiety, depression, fatigue, sleep disturbance and post-traumatic stress symptoms (PTSS) among intensive care survivors 3 months and 1 year after being discharged from an intensive care unit (ICU) and to determine whether pain is associated with higher prevalence of these symptoms 3 months and 1 year after ICU stay...
December 15, 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/29243318/effect-of-maturity-and-infection-on-the-rate-of-relaxation-of-the-respiratory-muscles-in-ventilated-newborn-infants
#18
Theodore Dassios, Ourania Kaltsogianni, Paul Dixon, Anne Greenough
AIM: To assess the respiratory muscle time constant of relaxation (τ), an index of respiratory muscle function in ventilated newborns. METHODS: Sixty-two infants (42 born prematurely) with a median gestational age of 29 [interquartile range (IQR) 26-37] weeks were prospectively studied. Measurement of τ was done during spontaneous breathing on endotracheal continuous positive airway pressure prior to extubation and τ was calculated from the reciprocal of the slope of the airway pressure decline versus time...
December 15, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29243292/effects-of-endovascular-cooling-on-infarct-size-in-st-segment-elevation-myocardial-infarction-a-patient-level-pooled-analysis-from-randomized-trials
#19
Michael Dae, William O'Neill, Cindy Grines, Simon Dixon, David Erlinge, Marko Noc, Michael Holzer, Anne Dee
OBJECTIVES: This study sought to examine the relationship between temperature at reperfusion and infarct size. BACKGROUND: Hypothermia consistently reduces infarct size when administered prior to reperfusion in animal studies, however, clinical results have been inconsistent. METHODS: We performed a patient-level pooled analysis from six randomized control trials of endovascular cooling during primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) in 629 patients in which infarct size was assessed within 1 month after randomization by either single-photon emission computed tomography (SPECT) or cardiac magnetic resonance imaging (cMR)...
December 14, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29243200/the-cascading-effects-of-multiple-dimensions-of%C3%A2-implementation-on-program-outcomes-a-test-of-a-theoretical-model
#20
Cady Berkel, Anne M Mauricio, Irwin N Sandler, Sharlene A Wolchik, Carlos G Gallo, C Hendricks Brown
This study tests a theoretical cascade model in which multiple dimensions of facilitator delivery predict indicators of participant responsiveness, which in turn lead to improvements in targeted program outcomes. An effectiveness trial of the 10-session New Beginnings Program for divorcing families was implemented in partnership with four county-level family courts. This study included 366 families assigned to the intervention condition who attended at least one session. Independent observers provided ratings of program delivery (i...
December 14, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
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