Read by QxMD icon Read


Whitni K Redman, Jay E Bryant, Gul Ahmad
AIM: This survey was carried out on the carcasses of 29 coyotes from Southeastern Nebraska and Shenandoah area of Iowa to document the helminths present in the intestinal track of these carnivorous animals. MATERIALS AND METHODS: A total of 29 adult coyote carcasses were generously donated in the autumn and winter (November-February) of 2014-2015 by trappers, fur buyers and hunters of Southeast Nebraska and Shenandoah area of Iowa. The intestine of individual animals were examined for the recovery of helminth parasites as per the established procedures...
September 2016: Veterinary World
Shenandoah Robinson, Jacqueline B Berglass, Jesse L Denson, Justin Berkner, Christopher V Anstine, Jesse L Winer, Jessie R Maxwell, Jianhua Qiu, Yirong Yang, Laurel O Sillerud, William P Meehan, Rebekah Mannix, Lauren L Jantzie
Traumatic brain injury (TBI) is a major public health issue, with recently increased awareness of the potential long-term sequelae of repetitive injury. Although TBI is common, objective diagnostic tools with sound neurobiological predictors of outcome are lacking. Indeed, such tools could help to identify those at risk for more severe outcomes after repetitive injury and improve understanding of biological underpinnings to provide important mechanistic insights. We tested the hypothesis that acute and subacute pathological injury, including the microgliosis that results from repeated mild closed head injury (rmCHI), is reflected in susceptibility-weighted magnetic resonance imaging and diffusion-tensor imaging microstructural abnormalities...
July 25, 2016: Journal of Neuroscience Research
Rebekah Mannix, Justin Berkner, Zhengrong Mei, Sasha Alcon, Jumana Hashim, Shenandoah Robinson, Lauren Jantzie, William P Meehan, Jianhua Qiu
Recently, there has been increasing interest in outcomes after repetitive mild traumatic brain injury (rmTBI) (e.g., sports concussions). Although most of the scientific attention has focused on elite athlete populations, the sequelae of rmTBI in children and young adults have not been well studied. Prior TBI studies have suggested that developmental differences in response to injury, including differences in excitotoxicity and inflammation, could result in differences in functional and histopathological outcomes after injury...
July 27, 2016: Journal of Neurotrauma
T M Coxon, B K Odhiambo, L C Giancarlo
The progressively declining ecological condition of the Chesapeake Bay is attributed to the influx of contaminants associated with sediment loads supplied by its largest tributaries. The continued urban expansion in the suburbs of Virginia cities, modern agricultural activities in the Shenandoah Valley, the anthropogenic and climate driven changes in fluvial system hydrodynamics and their potential associated impacts on trace metals enrichment in the bay's tributaries necessitate constant environmental monitoring of these important water bodies...
October 15, 2016: Science of the Total Environment
Annie F Johns, Scarlett E Graham, Meagan J Harris, April J Markiewicz, Jonah M Stinson, Wayne G Landis
We have conducted a series of regional scale risk assessments using the Bayesian Network Relative Risk Model (BN-RRM) to evaluate the efficacy of two remediation options in the reduction of risks to the South River and upper Shenandoah River study area. The two remediation options considered by South River managers were (1) the implementation of best management practices for agriculture (AgBMP) and (2) bank stabilization (BST) to reduce the input of mercury to the river. Eight endpoints were chosen to be part of the risk assessment based on stakeholder input...
February 24, 2016: Integrated Environmental Assessment and Management
Shenandoah Robinson, Jesse L Winer, Justin Berkner, Lindsay A S Chan, Jesse L Denson, Jessie R Maxwell, Yirong Yang, Laurel O Sillerud, Robert C Tasker, William P Meehan, Rebekah Mannix, Lauren L Jantzie
OBJECTIVE Traumatic brain injury (TBI) is a leading cause of death and severe morbidity for otherwise healthy full-term infants around the world. Currently, the primary treatment for infant TBI is supportive, as no targeted therapies exist to actively promote recovery. The developing infant brain, in particular, has a unique response to injury and the potential for repair, both of which vary with maturation. Targeted interventions and objective measures of therapeutic efficacy are needed in this special population...
June 2016: Journal of Neurosurgery. Pediatrics
Wayne G Landis, Kimberly K Ayre, Annie F Johns, Heather M Summers, Jonah Stinson, Meagan J Harris, Carlie E Herring, April J Markiewicz
We have conducted a regional scale risk assessment using the Bayesian Network Relative Risk Model (BN-RRM) to calculate the ecological risks to the South River and upper Shenandoah River study area. Four biological endpoints (smallmouth bass, white sucker, Belted Kingfisher and Carolina Wren) and four abiotic endpoints (Fishing River Use, Swimming River Use, and Boating River Use and Water Quality Standards) were included in this risk assessment based on stakeholder input. Although mercury (Hg) contamination was the original imputes for the site being remediated, other chemical and physical stressors were evaluated...
January 22, 2016: Integrated Environmental Assessment and Management
Lauren L Jantzie, Jesse L Winer, Jessie R Maxwell, Lindsay A S Chan, Shenandoah Robinson
Encephalopathy of prematurity (EoP) is a term that encompasses the central nervous system (CNS) abnormalities associated with preterm birth. To best advance translational objectives and uncover new therapeutic strategies for brain injury associated with preterm birth, preclinical models of EoP must include similar mechanisms of prenatal global injury observed in humans and involve multiple components of the maternal-placental-fetal system. Ideally, models should produce a similar spectrum of functional deficits in the mature animal and recapitulate multiple aspects of the pathophysiology...
2015: Journal of Visualized Experiments: JoVE
Shenandoah Robinson
No abstract text is available yet for this article.
April 2016: Journal of Neurosurgery. Pediatrics
Jessie R Maxwell, Jesse L Denson, Nancy E Joste, Shenandoah Robinson, Lauren L Jantzie
INTRODUCTION: Preterm birth is a major cause of infant morbidity and long-term disability, and is associated with numerous central nervous system (CNS) deficits. Infants exposed to intrauterine inflammation, specifically chorioamnionitis, are at risk for very early preterm birth and neurological complications including cerebral palsy, epilepsy, and behavioral and cognitive deficits. However, placenta-brain axis abnormalities and their relationship to subsequent permanent CNS injury remain poorly defined...
December 2015: Placenta
Lauren L Jantzie, Jesse L Winer, Christopher J Corbett, Shenandoah Robinson
Preterm infants suffer central nervous system (CNS) injury from hypoxia-ischemia and inflammation - termed encephalopathy of prematurity. Mature CNS injury activates caspase and calpain proteases. Erythropoietin (EPO) limits apoptosis mediated by activated caspases, but its role in modulating calpain activation has not yet been investigated extensively following injury to the developing CNS. We hypothesized that excess calpain activation degrades developmentally regulated molecules essential for CNS circuit formation, myelination and axon integrity, including neuronal potassium-chloride co-transporter (KCC2), myelin basic protein (MBP) and phosphorylated neurofilament (pNF), respectively...
2016: Developmental Neuroscience
Shenandoah Robinson
No abstract text is available yet for this article.
March 2016: Journal of Neurosurgery
Lauren L Jantzie, Paulina M Getsy, Jesse L Denson, Daniel J Firl, Jessie R Maxwell, Danny A Rogers, Christopher G Wilson, Shenandoah Robinson
Infants who suffer perinatal brain injury, including those with encephalopathy of prematurity, are prone to chronic neurological deficits, including epilepsy, cognitive impairment, and behavioral problems, such as anxiety, inattention, and poor social interaction. These deficits, especially in combination, pose the greatest hindrance to these children becoming independent adults. Cerebral function depends on adequate development of essential inhibitory neural circuits and the appropriate amount of excitation and inhibition at specific stages of maturation...
2015: Frontiers in Cellular Neuroscience
Lauren L Jantzie, Shenandoah Robinson
Encephalopathy of prematurity (EoP) encompasses the central nervous system (CNS) abnormalities associated with injury from preterm birth. Although rapid progress is being made, limited understanding exists of how cellular and molecular CNS injury from early birth manifests as the myriad of neurological deficits in children who are born preterm. More importantly, this lack of direct insight into the pathogenesis of these deficits hinders both our ability to diagnose those infants who are at risk in real time and could potentially benefit from treatment and our ability to develop more effective interventions...
2015: Developmental Neuroscience
Yoichiro Kanno, Benjamin H Letcher, Nathaniel P Hitt, David A Boughton, John E B Wofford, Elise F Zipkin
Climate change affects seasonal weather patterns, but little is known about the relative importance of seasonal weather patterns on animal population vital rates. Even when such information exists, data are typically only available from intensive fieldwork (e.g., mark-recapture studies) at a limited spatial extent. Here, we investigated effects of seasonal air temperature and precipitation (fall, winter, and spring) on survival and recruitment of brook trout (Salvelinus fontinalis) at a broad spatial scale using a novel stage-structured population model...
May 2015: Global Change Biology
Rebekah Mannix, Jacqueline Berglass, Justin Berkner, Philippe Moleus, Jianhua Qiu, Lauren L Jantzie, William P Meehan, Rachel M Stanley, Shenandoah Robinson
OBJECT: While progesterone has been well studied in experimental models of adult traumatic brain injury (TBI), it has not been evaluated in pediatric models. The study of promising interventions in pediatric TBI is important because children have the highest public health burden of such injuries. Therapies that are beneficial in adults may not necessarily be effective in the pediatric population. The purpose of this study was to evaluate whether progesterone treatment improves outcomes in an experimental model of pediatric TBI...
December 2014: Journal of Neurosurgery
Rebekah Mannix, Jacqueline Berglass, Justin Berkner, Philippe Moleus, Jianhua Qiu, Nick Andrews, Georgia Gunner, Laura Berglass, Lauren L Jantzie, Shenandoah Robinson, William P Meehan
OBJECT: With the recent increasing interest in outcomes after repetitive mild traumatic brain injury (rmTBI; e.g., sports concussions), several models of rmTBI have been established. Characterizing these models in terms of behavioral and histopathological outcomes is vital to assess their clinical translatability. The purpose of this study is to provide an in-depth behavioral and histopathological phenotype of a clinically relevant model of rmTBI. METHODS: The authors used a previously published weight-drop model of rmTBI (7 injuries in 9 days) in 2- to 3-month-old mice that produces cognitive deficits without persistent loss of consciousness, seizures, gross structural imaging findings, or microscopic evidence of structural brain damage...
December 2014: Journal of Neurosurgery
Lauren L Jantzie, Christopher J Corbett, Jacqueline Berglass, Daniel J Firl, Julian Flores, Rebekah Mannix, Shenandoah Robinson
BACKGROUND: Infants born preterm commonly suffer from a combination of hypoxia-ischemia (HI) and infectious perinatal inflammatory insults that lead to cerebral palsy, cognitive delay, behavioral issues and epilepsy. Using a novel rat model of combined late gestation HI and lipopolysaccharide (LPS)-induced inflammation, we tested our hypothesis that inflammation from HI and LPS differentially affects gliosis, white matter development and motor impairment during the first postnatal month...
2014: Journal of Neuroinflammation
John Young, Luke Iwanowicz, Adam Sperry, Vicki Blazer
Endocrine-disrupting compounds (EDCs) are becoming of increasing concern in waterways of the USA and worldwide. What remains poorly understood, however, is how prevalent these emerging contaminants are in the environment and what methods are best able to determine landscape sources of EDCs. We describe the development of a spatially structured sampling design and a reconnaissance survey of estrogenic activity along gradients of land use within sub-watersheds. We present this example as a useful approach for state and federal agencies with an interest in identifying locations potentially impacted by EDCs that warrant more intensive, focused research...
September 2014: Environmental Monitoring and Assessment
Lauren L Jantzie, Christopher J Corbett, Daniel J Firl, Shenandoah Robinson
Preterm birth impacts brain development and leads to chronic deficits including cognitive delay, behavioral problems, and epilepsy. Premature loss of the subplate, a transient subcortical layer that guides development of the cerebral cortex and axonal refinement, has been implicated in these neurological disorders. Subplate neurons influence postnatal upregulation of the potassium chloride co-transporter KCC2 and maturation of γ-amino-butyric acid A receptor (GABAAR) subunits. We hypothesized that prenatal transient systemic hypoxia-ischemia (TSHI) in Sprague-Dawley rats that mimic brain injury from extreme prematurity in humans would cause premature subplate loss and affect cortical layer IV development...
September 2015: Cerebral Cortex
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"