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JOURNAL ARTICLE
Jiurong Liang, Guanling Huang, Xue Liu, Xuexi Zhang, Anas Rabata, Ningshan Liu, Kai Fang, Forough Taghavifar, Kristy Dai, Vrishika Kulur, Dianhua Jiang, Paul W Noble
Idiopathic pulmonary fibrosis (IPF) is an aging-associated interstitial lung disease resulting from repeated epithelial injury and inadequate epithelial repair. Alveolar type II cells (AEC2) are progenitor cells that maintain epithelial homeostasis and repair the lung after injury. In the current study, we assessed lipid metabolism in AEC2s from human lungs of IPF patients and healthy donors, as well as AEC2s from bleomycin-injured young and old mice. Through single cell RNA sequencing (scRNA-seq), we observed that lipid metabolism-related genes were downregulated in IPF AEC2s and bleomycin-injured mouse AEC2s...
April 24, 2024: American Journal of Respiratory Cell and Molecular Biology
#2
JOURNAL ARTICLE
Ji Yang, Yiming Yao, Xiaoxiao Li, Ana He, Shijie Chen, Yulong Wang, Xiaoyu Dong, Hao Chen, Yu Wang, Lei Wang, Hongwen Sun
The indoor environment is a typical source for organophosphorus flame retardants and plasticizers (OPFRs), yet the source characteristics of OPFRs in different microenvironments remain less clear. This study collected 109 indoor air samples and 34 paired indoor dust samples from 4 typical microenvironments within a university in Tianjin, China, including the dormitory, office, library, and information center. 29 target OPFRs were analyzed, and novel organophosphorus compounds (NOPs) were identified by fragment-based nontarget analysis...
April 24, 2024: Environmental Science & Technology
#3
JOURNAL ARTICLE
Latifa Bakiri, Sebastian C Hasenfuss, Ana Guío-Carrión, Martin K Thomsen, Peter Hasselblatt, Erwin F Wagner
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death. HCC incidence is on the rise, while treatment options remain limited. Thus, a better understanding of the molecular pathways involved in HCC development has become a priority to guide future therapies. While previous studies implicated the Activator Protein-1 (AP-1) (Fos/Jun) transcription factor family members c-Fos and c-Jun in HCC formation, the contribution of Fos-related antigens (Fra-) 1 and 2 is unknown. Here, we show that hepatocyte-restricted expression of a single chain c-Jun~Fra-2 protein, which functionally mimics the c-Jun/Fra-2 AP-1 dimer, results in spontaneous HCC formation in c-Jun~Fra-2hep mice...
April 30, 2024: Proceedings of the National Academy of Sciences of the United States of America
#4
JOURNAL ARTICLE
Lin Wang, Angkana T Huang, Leah C Katzelnick, Noémie Lefrancq, Ana Coello Escoto, Loréna Duret, Nayeem Chowdhury, Richard Jarman, Matthew A Conte, Irina Maljkovic Berry, Stefan Fernandez, Chonticha Klungthong, Butsaya Thaisomboonsuk, Piyarat Suntarattiwong, Warunee Vandepitte, Stephen S Whitehead, Simon Cauchemez, Derek A T Cummings, Henrik Salje
Many pathogens continuously change their protein structure in response to immune-driven selection, resulting in weakened protection even in previously exposed individuals. In addition, for some pathogens, such as dengue virus, poorly targeted immunity is associated with increased risk of severe disease through a mechanism known as antibody-dependent enhancement. However, it remains unclear whether the antigenic distances between an individual's first infection and subsequent exposures dictate disease risk, explaining the observed large-scale differences in dengue hospitalizations across years...
April 24, 2024: Science Translational Medicine
#5
JOURNAL ARTICLE
Maya Spaur, Marta Galvez-Fernandez, Qixuan Chen, Melissa A Lombard, Benjamin C Bostick, Pam Factor-Litvak, Amanda M Fretts, Steven J Shea, Ana Navas-Acien, Anne E Nigra
OBJECTIVE: We examined the association of arsenic in federally regulated community water systems (CWSs) and unregulated private wells with type 2 diabetes (T2D) incidence in the Strong Heart Family Study (SHFS), a prospective study of American Indian communities, and the Multi-Ethnic Study of Atherosclerosis (MESA), a prospective study of racially and ethnically diverse urban U.S. communities. RESEARCH DESIGN AND METHODS: We evaluated 1,791 participants from SHFS and 5,777 participants from MESA who had water arsenic estimates available and were free of T2D at baseline (2001-2003 and 2000-2002, respectively)...
April 24, 2024: Diabetes Care
#6
JOURNAL ARTICLE
Teodora Figueiredo, Luís Midão, Pedro Rocha, Sara Cruz, Gisela Lameira, Paulo Conceição, Rui J G Ramos, Luísa Batista, Helena Corvacho, Marta Almada, Ana Martins, Cecília Rocha, Anabela Ribeiro, Fernando Alves, Elísio Costa
Climate change and rapid population ageing pose challenges for communities and public policies. This systematic review aims to gather data from studies that present health indicators establishing the connection between climate change and the physical and mental health of the older population (≥ 65 years), who experience a heightened vulnerability to the impacts of climate change when compared to other age cohorts. This review was conducted according to the PICO strategy and following Cochrane and PRISMA guidelines...
2024: PloS One
#7
JOURNAL ARTICLE
Silvia Carvalho, Luna Zea-Redondo, Tsz Ching Chloe Tang, Philipp Stachel-Braum, Duncan Miller, Paulo Caldas, Alexander Kukalev, Sebastian Diecke, Stefanie Grosswendt, Ana Rita Grosso, Ana Pombo
Embryo development is an orchestrated process that relies on tight regulation of gene expression to guide cell differentiation and fate decisions. The Srrm2 splicing factor has recently been implicated in developmental disorders and diseases, but its role in early mammalian development remains unexplored. Here, we show that Srrm2 dosage is critical for maintaining embryonic stem cell pluripotency and cell identity. Srrm2 heterozygosity promotes loss of stemness, characterised by the coexistence of cells expressing naive and formative pluripotency markers, together with extensive changes in gene expression, including genes regulated by serum-response transcription factor (SRF) and differentiation-related genes...
April 15, 2024: Biology Open
#8
JOURNAL ARTICLE
Humberto Pires, Sérgio Santos-Silva, Andreia V S Cruz, Luís Cardoso, Ana Patrícia Lopes, Maria A Pereira, Carmen Nóbrega, Ana Cristina Mega, Carla Santos, Rita Cruz, Fernando Esteves, Helena Vala, Ana Cristina Matos, Patrícia F Barradas, Ana Cláudia Coelho, João R Mesquita
Coxiella burnetii is the etiologic agent of Q fever, a worldwide zoonosis. Cattle, sheep and goats are considered the main reservoirs of the disease. Transmission to humans occurs mainly through the inhalation of infectious aerosols from milk, faeces, urine, and birth products from infected ruminants. In this study, a 2-year longitudinal approach was performed to ascertain the excretion of C. burnetii in bulk tank milk samples of sheep from a mountain plateau in central Portugal, with sampling conducted during the years 2015 and 2016...
April 24, 2024: Veterinary Research Communications
#9
JOURNAL ARTICLE
Rachel L Batterham, Roger J Bedimo, Ricardo S Diaz, Giovanni Guaraldi, Janet Lo, Esteban Martínez, Grace A McComsey, Ana Milinkovic, Toshio Naito, Sebastian Noe, Donal O'Shea, Roger Paredes, Jonathan M Schapiro, Mark S Sulkowski, François Venter, Laura Waters, Ilksen Ungan Yoruk, Benjamin Young
OBJECTIVES: To develop consensus data statements and clinical recommendations to provide guidance for improving cardiometabolic health outcomes in people with HIV based on the knowledge and experience of an international panel of experts. METHODS: A targeted literature review including 281 conference presentations, peer-reviewed articles, and background references on cardiometabolic health in adults with HIV published between January 2016 and April 2022 was conducted and used to develop draft consensus data statements...
April 24, 2024: Journal of Antimicrobial Chemotherapy
#10
JOURNAL ARTICLE
Ana Maria Jucá, Olivia Santana Jorge, Yasmin Rosalin Moreira, Matheus Lotto, Tamires Sá Menezes, Thiago Cruvinel
OBJECTIVE: This infodemiology study aimed to analyze characteristics of English-language Instagram posts on 'Biological Dentistry'. MATERIALS AND METHODS: Using CrowdTangle, we analyzed 500 'Biological Dentistry' posts published on Instagram from May 2017 to May 2022. Two researchers assessed each post for facticity, motivation, author's profile, sentiment, and interaction metrics. Statistical analysis was employed to compare interaction metrics between dichotomized categories of posts' characteristics and determine predictors of misinformation and user engagement...
April 24, 2024: Acta Odontologica Scandinavica
#11
JOURNAL ARTICLE
Michel Pieren, Ana Abáigar Gutiérrez-Solana, Rosa María Antonijoan Arbós, Gary W Boyle, Myriam Davila, Maria Davy, Marc Gitzinger, Lisa Husband, María S Martínez-Martínez, Dolores Ochoa Mazarro, Eleni Pefani, Sophie L Penman, Modesto J Remuiñán, Georgios Vlasakakis, Markus Zeitlinger, Glenn E Dale
BACKGROUND: The clinical candidate alpibectir augments the activity of, and overcomes resistance to, the anti-TB drug ethionamide in vitro and in vivo. OBJECTIVES: A Phase 1, double-blind, randomized, placebo-controlled study to investigate the safety, tolerability, pharmacokinetics (PK) and food effect of alpibectir administered as single and multiple oral doses in healthy volunteers (NCT04654143). METHODS: Eighty participants were randomized...
April 24, 2024: Journal of Antimicrobial Chemotherapy
#12
JOURNAL ARTICLE
Ana L Ríos-López, Jorge Dávila-Aviña, Gloria M González, Orlando Flores-Maldonado
Aspergillus fumigatus and Fusarium solani infections have become severe health threat; both pathogens are considered a priority due to the increasing emergence of antifungal-resistant strains and high mortality rates. Therefore, the discovery of new therapeutic strategies has become crucial. In this study, we evaluated the antifungal and antivirulence effects of vanillin and tannic acid against Aspergillus fumigatus and Fusarium solani. The minimum inhibitory concentrations of the compounds were determined by the microdilution method in RPMI broth in 96-well microplates according to CLSI...
April 24, 2024: Current Microbiology
#13
JOURNAL ARTICLE
Fatima Aidil-Carvalho, Ana Caulino-Rocha, Joaquim Alexandre Ribeiro, Diana Cunha-Reis
Novelty influences hippocampal-dependent memory through metaplasticity. Mismatch novelty detection activates the human hippocampal CA1 area and enhances rat hippocampal-dependent learning and exploration. Remarkably, mismatch novelty training (NT) also enhances rodent hippocampal synaptic plasticity while inhibition of VIP interneurons promotes rodent exploration. Since VIP, acting on VPAC1 receptors (Rs), restrains hippocampal LTP and depotentiation by modulating disinhibition, we now investigated the impact of NT on VPAC1 modulation of hippocampal synaptic plasticity in male Wistar rats...
April 2024: Journal of Neuroscience Research
#14
JOURNAL ARTICLE
Jason Pérez, Alejandro Hernández-Soto, Ana Abdelnour-Esquivel, Walter Vargas-Segura, William Watson-Guido, Andrés Gatica-Arias
Gamma radiation (60 Co)-induced mutagenesis offers an alternative to develop rice lines by accelerating the spontaneous mutation process and increasing the pool of allelic variants available for breeding. Ionizing radiation works by direct or indirect damage to DNA and subsequent mutations. The technique can take advantage of in vitro protocols to optimize resources and accelerate the development of traits. This is achieved by exposing mutants to a selection agent of interest in controlled conditions and evaluating large numbers of plants in reduced areas...
2024: Methods in Molecular Biology
#15
JOURNAL ARTICLE
Madison A Ward, Janakiram R Vangala, Hatem Elif Kamber Kaya, Holly A Byers, Nayyerehalsadat Hosseini, Antonio Diaz, Ana Maria Cuervo, Susmita Kaushik, Senthil K Radhakrishnan
Cells exposed to proteotoxic stress invoke adaptive responses aimed at restoring proteostasis. Our previous studies have established a firm role for the transcription factor Nuclear factor-erythroid derived-2-related factor-1 (Nrf1) in responding to proteotoxic stress elicited by inhibition of cellular proteasome. Following proteasome inhibition, Nrf1 mediates new proteasome synthesis, thus enabling the cells to mitigate the proteotoxic stress. Here, we report that under similar circumstances, multiple components of the autophagy-lysosomal pathway (ALP) were transcriptionally upregulated in an Nrf1-dependent fashion, thus providing the cells with an additional route to cope with proteasome insufficiency...
June 3, 2024: Journal of Cell Biology
#16
JOURNAL ARTICLE
McKenzie A Dirr, Areeba Ahmed, Daniel I Schlessinger, Misha Haq, Victoria Shi, Eric Koza, Melissa Ma, Rachel E Christensen, Sarah A Ibrahim, Jochen Schmitt, Lena Johannsen, Yuka Asai, Hilary E Baldwin, Enzo Berardesca, Brian Berman, Ana Carolina Vieira, Anna L Chien, David E Cohen, James Q Del Rosso, Jacquelyn Dosal, Lynn A Drake, Steven R Feldman, Alan B Fleischer, Adam Friedman, Emmy Graber, Julie C Harper, Yolanda R Helfrich, Gregor B Jemec, Sandra M Johnson, Rajani Katta, Peter Lio, Lisa E Maier, George Martin, Arielle R Nagler, Isaac M Neuhaus, Melis Palamar, Lawrence C Parish, Theodore Rosen, Stephen P Shumack, James A Solomon, Emil A Tanghetti, Guy F Webster, Allison Weinkle, Jonathan S Weiss, Edward J Wladis, Ian A Maher, Joseph F Sobanko, Todd V Cartee, Brian A Cahn, Murad Alam, Bianca Y Kang, Sanjana Iyengar, Noor Anvery, Erkan Alpsoy, Anthony Bewley, Clio Dessinioti, Alexander Egeberg, Burhan Engin, Harald P M Gollnick, Dimitrios Ioannides, Hei Sung Kim, Elizabeth Lazaridou, Ji Li, Hester Gail Lim, Giuseppe Micali, Clivia Maria Moraes de Oliveira, Lucero Noguera-Morel, Aurora Parodi, Markus Reinholz, Dae Hun Suh, Qiuning Sun, Esther J van Zuuren, Uwe Wollina, Youwen Zhou, Catherine Zip, Emily Poon, Ross Pearlman
IMPORTANCE: Inconsistent reporting of outcomes in clinical trials of rosacea is impeding and likely preventing accurate data pooling and meta-analyses. There is a need for standardization of outcomes assessed during intervention trials of rosacea. OBJECTIVE: To develop a rosacea core outcome set (COS) based on key domains that are globally relevant and applicable to all demographic groups to be used as a minimum list of outcomes for reporting by rosacea clinical trials, and when appropriate, in clinical practice...
April 24, 2024: JAMA Dermatology
#17
JOURNAL ARTICLE
Rodrigo Soares Ribeiro, Natália Sperli Geraldes Marin Dos Santos Sasaki, Alessandra Marinela de Abreu Queiroz, Ana Cecília Mota Ferreira, Gabriela de Souza Segura, Maria de Lourdes Sperli Geraldes Santos, Lara Helk de Souza, Luciano Garcia Lourenção
OBJECTIVE: The objective of this study was to analyze the factors that influence the positivity of treponemal and non-treponemal tests in cases of congenital syphilis. METHODS: This cross-sectional and correlational study was carried out from the analysis of the database of Disease and Notification Information System (SINAN, in Portuguese) using the data obtained through the Epidemiological Surveillance Group 29, with 639 notifications of congenital syphilis between 2007 and 2018...
2024: Revista da Associação Médica Brasileira
#18
JOURNAL ARTICLE
Ana Paula Sato, Tiffany Christiny Emmerich da Silva, Thamires Pires de Pontes, Aline Luiza Konell, Luiz Daniel de Barros, Mary Suzan Varaschin, Ivam Moreira de Oliveira Junior, Adrien Wilhelm Dilger Sanches, Rosangela Locatelli-Dittrich
Toxoplasma gondii and Neospora caninum are two closely related protozoans that infect a wide range of animals, including birds. However, the occurrence of N. caninum and T. gondii in seabirds is unknown. Therefore, this study aimed to determine the presence of T. gondii and N. caninum DNA in tissue samples of seabirds. Tissue samples of the pectoral muscles, heart, and brain were collected from 47 birds along the coastline of Santa Catarina State, SC, Brazil. The DNA was extracted from the tissues and screened using nested-PCR (nPCR) targeting internal transcribed spacer 1 (ITS1)...
2024: Brazilian Journal of Veterinary Parasitology
#19
JOURNAL ARTICLE
Beatriz de Camargo Poker, Viviane de Cássia Oliveira, Ana Paula Macedo, Mariane Gonçalves, Ana Paula Ramos, Cláudia Helena Silva-Lovato
OBJECTIVE: This study evaluated the surface roughness, wettability and adhesion of multispecies biofilms (Candida albicans, Staphylococcus aureus and Streptococcus mutans) on 3D-printed resins for complete denture bases and teeth compared to conventional resins (heat-polymerized acrylic resin; artificial pre-fabricated teeth). METHODOLOGY: Circular specimens (n=39; 6.0 mm Ø × 2.0 mm) of each group were subjected to roughness (n=30), wettability (n=30) and biofilm adhesion (n=9) tests...
2024: Journal of Applied Oral Science: Revista FOB
#20
COMPARATIVE STUDY
Karim Yaqub Ibrahim, Raquel Megale Moreira, Carolina Ferreira Dos Santos, Tânia Mara Varejão Strabelli, Juliana de Cássia Belizário, Maria Isabel de Moraes Pinto, Ana Karolina Barreto Berselli Marinho, Juliana Marquezi Pereira, Liliane Saraiva de Mello, Mauricio Cesar Ando, Vitor Gabriel Lopes da Silva, Paula Keiko Sato, Marcos Alves de Lima, João Italo Dias França, Ana Paula Loch, Karina Takesaki Miyaji, Vanessa Infante, Alexander Roberto Precioso, Ana Marli Christovam Sartori
Inactivated COVID-19 vaccines data in immunocompromised individuals are scarce. This trial assessed the immunogenicity of two CoronaVac doses and additional BNT162b2 mRNA vaccine doses in immunocompromised (IC) and immunocompetent (H) individuals. Adults with solid organ transplant (SOT), hematopoietic stem cell transplant, cancer, inborn immunity errors or rheumatic diseases were included in the IC group. Immunocompetent adults were used as control group for comparison. Participants received two CoronaVac doses within a 28-day interval...
2024: Revista do Instituto de Medicina Tropical de São Paulo
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