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https://www.readbyqxmd.com/read/28214224/escherichia-coli-sequence-type-73-as-a-cause-of-community-acquired-urinary-tract-infection-in-men-and-women-in-rio-de-janeiro-brazil
#1
Ana Paula de Souza da-Silva, Viviane Santos de Sousa, Natacha Martins, Rubens Clayton da Silva Dias, Raquel Regina Bonelli, Lee W Riley, Beatriz Meurer Moreira
Escherichia coli clones ST131, ST69, ST95, and ST73 are frequent causes of urinary tract infections (UTI) and bloodstream infections. Specific clones and virulence profiles of E. coli causing UTI in men has been rarely described. The aim of this study was to characterize patient and clonal characteristics of community-acquired UTI caused by E. coli in men (n=12) and women (n=127) in Rio de Janeiro, Brazil, complementing a previous work. We characterized isolates in phylogenetic groups, ERIC2-PCR and PFGE types, MLST, genome similarity and virulence gene-profiles...
February 7, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28214215/immunoexpression-of-gadd45%C3%AE-in-the-myocardium-of-newborns-experiencing-perinatal-hypoxia
#2
Mona Adalgisa Simões, Francisco Cesar Pabis, Ana Karyn Ehrenfried de Freitas, Marina Luise Viola de Azevedo, Daiane Cristine Martins Ronchi, Lucia de Noronha
AIM: Among the several organs affected by perinatal hypoxia, the heart plays a central role, with cell death caused mainly by apoptosis. One of the biomarkers most often linked to hypoxia-derived apoptosis of cardiomyocytes in animals is Gadd45β. From the published literature, Gadd45β is proposed as a biomarker of hypoxia-induced lesion in cardiomyocytes, both in vitro, as well as in animal models. Our study suggests that this protein can be used as an early biomarker of cell damage in neonate's cardiomyocytes (humans specimens), a process that can ultimately lead to apoptosis...
January 31, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28214154/bendopnea-a-new-symptom-for-the-differential-diagnosis-of-chronic-cardiopulmonary-disease
#3
Ana Teresa Timóteo
No abstract text is available yet for this article.
February 14, 2017: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/28214050/communication-deficits-and-avoidance-of-angry-faces-in-children-with-autism-spectrum-disorder
#4
Ana García-Blanco, Concepción López-Soler, Máximo Vento, María Carmen García-Blanco, Belén Gago, Manuel Perea
BACKGROUND: Understanding how emotional faces are processed is important to help characterize the social deficits in Autism Spectrum Disorder (ASD). AIMS: We examined: (i) whether attention is modulated by emotional facial expression; (ii) the time course of the attentional preferences (short vs. long stimulus presentation rates); and (iii) the association between attentional biases and autistic symptomatology. METHOD AND PROCEDURES: We applied a dot-probe experiment with emotional faces (happy, sad, and angry)...
February 14, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28214022/circulating-il-6-upregulates-il-10-production-in-splenic-cd4-t-cells-and-limits-acute-kidney-injury-induced-lung-inflammation
#5
Ana Andres-Hernando, Kayo Okamura, Rhea Bhargava, Carol M Kiekhaefer, Danielle Soranno, Lara A Kirkbride-Romeo, Hyo-Wook Gil, Chris Altmann, Sarah Faubel
Although it is well established that acute kidney injury (AKI) is a proinflammatory state, little is known about the endogenous counter-inflammatory response. IL-6 is traditionally considered a pro-inflammatory cytokine that is elevated in the serum in both human and murine AKI. However, IL-6 is known to have anti-inflammatory effects. Here we sought to investigate the role of IL-6 in the counter-inflammatory response after AKI, particularly in regard to the anti-inflammatory cytokine IL-10. Ischemic AKI was induced by bilateral renal pedicle clamping...
February 14, 2017: Kidney International
https://www.readbyqxmd.com/read/28213633/associations-between-pain-catastrophizing-and-cognitive-fusion-in-relation-to-pain-and-upper-extremity-function-among-hand-and-upper-extremity-surgery-patients
#6
Sezai Özkan, Emily L Zale, David Ring, Ana-Maria Vranceanu
BACKGROUND: Patients who present to hand surgery practices are at increased risk of psychological distress, pain, and disability. Greater catastrophic thinking about pain is associated with greater pain intensity, and initial evidence suggest that, together, catastrophic thinking about pain and cognitive fusion (i.e., interpretation of thoughts as true) are associated with poorer pain outcomes. PURPOSE: We tested whether cognitive fusion or catastrophic thinking interacts in relation to pain and upper extremity physical function among patients seeking care from a hand surgeon...
February 17, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28213218/dynamic-flow-through-approach-to-evaluate-readily-bioaccessible-antioxidants-in-solid-food-samples
#7
Miguel A Maia, Tânia R P Soares, Ana I P Mota, María Rosende, Luís M Magalhães, Manuel Miró, Marcela A Segundo
Release of bioactive compounds from food matrices is regarded as the first step towards their human bioavailability. The objective of this work was the implementation of an affordable and robust flow-through device for expedient dynamic leaching experiments aiming at the assessment of readily bioaccessible antioxidant compounds in solid food commodities. A simple configuration is proposed using commercially available devices containing regenerated cellulose filters placed in polypropylene holders to entrap the solid sample, featuring a disposable, single use extraction chamber...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28213126/the-galactose-induced-decrease-in-phosphate-levels-leads-to-toxicity-in-yeast-models-of-galactosemia
#8
Caio M Machado, Evandro A De-Souza, Ana Luiza F V De-Queiroz, Felipe S A Pimentel, Guilherme F S Silva, Fabio M Gomes, Mónica Montero-Lomelí, Claudio A Masuda
Classic galactosemia is an inborn error of metabolism caused by deleterious mutations in the GALT gene. A number of evidences indicate that the galactose-1-phosphate accumulation observed in patient cells is a cause of toxicity in this disease. Nevertheless, the consequent molecular events caused by the galactose-1-phosphate accumulation remain elusive. Here we show that intracellular inorganic phosphate levels decreased when yeast models of classic galactosemia were exposed to galactose. The decrease in phosphate levels is probably due to the trapping of phosphate in the accumulated galactose-1-phosphate since the deletion of the galactokinase encoding gene GAL1 suppressed this phenotype...
February 14, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28213105/anxiolytic-and-antidepressant-like-effects-of-an-aqueous-extract-of-tanacetum-parthenium-l-schultz-bip-asteraceae-in-mice
#9
Jorge Cárdenas, Valeria Reyes-Pérez, María Dolores Hernández-Navarro, Ana María Dorantes-Barrón, Salvador Almazán, Rosa Estrada-Reyes
AIM: Tanacetum parthenium L. Schultz-Bip (Asteraceae) is widely used worldwide in traditional medicine for the treatment of convulsions and culture-bound syndromes such as susto (fear). The aim of this work was to evaluate the anxiolytic- and antidepressant-like effects of an aqueous extract of T. parthenium in behavioral paradigms in mice. The effects of T. parthenium were compared with those produced by anxiolytic and antidepressant drugs. We carried out the chemical characterization of the main constituents of T...
February 14, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28213102/comparison-of-multiplate-and-verifynow-platelet-function-tests-in-predicting-clinical-outcome-in-patients-with-acute-coronary-syndromes
#10
Peter D Larsen, Ana S Holley, Alexander Sasse, Ali Al-Sinan, Sarah Fairley, Scott A Harding
INTRODUCTION: This study examined the ability of two widely used "point of care" platelet function assays, VerifyNow and Multiplate, to predict adverse outcomes in patients with acute coronary syndromes (ACS). METHODS: We examined platelet reactivity using VerifyNow and Multiplate P2Y12 assays in patients with ACS and the relationship between platelet reactivity and both MACE (defined as a composite of death, myocardial infarction, stroke, stent thrombosis and unplanned revascularisation) and TIMI major bleeding at 1year...
February 10, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28213057/utilization-of-sentinel-lymph-node-biopsy-for-uterine-cancer
#11
Jason D Wright, Stephanie Cham, Ling Chen, William M Burke, June Y Hou, Ana I Tergas, Vrunda Desai, Jim C Hu, Cande V Ananth, Alfred I Neugut, Dawn L Hershman
BACKGROUND: To limit the potential short and long-term morbidity of lymphadenectomy, sentinel lymph node (SLN) biopsy has been proposed for endometrial cancer. The principle of SLN biopsy relies on removal of a small number of lymph nodes that are the first drainage basins from a tumor and thus the most likely to harbor tumor cells. While the procedure may reduce morbidity, efficacy data is limited and little is known about how commonly the procedure is performed. OBJECTIVE: We examined the patterns and predictors of use of SLN biopsy and outcomes of the procedure in women with endometrial cancer who underwent hysterectomy...
February 14, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28213051/spontaneous-experimental-atherosclerosis-in-hypercholesterolemic-mice-advances-with-ageing-and-correlates-with-mitochondrial-reactive-oxygen-species
#12
Gabriel G Dorighello, Bruno A Paim, Ana Catarina Leite, Anibal E Vercesi, Helena C F Oliveira
Ageing and atherosclerosis are associated with oxidative stress. Mitochondrial redox function declines with ageing. Here we tested whether ageing LDL receptor knockout mice (LDLr(-/-)) develop spontaneous atherosclerosis and whether mitochondrial reactive oxygen species (mtROS) correlate with atherosclerosis. Compared with young mice, aged LDLr(-/-) mice exhibited 20-fold larger aortic lesion size, although the plasma cholesterol levels did not vary between age groups. The lesion sizes increased exponentially from 3 to 24months of age (r=0...
February 14, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28213015/lettuce-and-fruits-as-a-source-of-multidrug-resistant-acinetobacter-spp
#13
Ana Carvalheira, Joana Silva, Paula Teixeira
The role of ready-to-eat products as a reservoir of pathogenic species of Acinetobacter remains unclear. The objective of the present study was to evaluate the presence of Acinetobacter species in lettuces and fruits marketed in Portugal, and their susceptibility to antimicrobials. Acinetobacter spp. were isolated from 77.9% of the samples and these microorganisms were also found as endophytes (i.e. present within the plant tissue) in 12 of 20 samples of lettuces analysed. Among 253 isolates that were identified as belonging to this genus, 181 presented different PFGE profiles, representing different strains...
June 2017: Food Microbiology
https://www.readbyqxmd.com/read/28212998/what-factors-do-patients-consider-most-important-in-making-lung-cancer-screening-decisions-findings-from-a-demonstration-project-conducted-in-the-veterans-health-administration
#14
Sarah E Lillie, Steven S Fu, Angela E Fabbrini, Kathryn L Rice, Barbara Clothier, David B Nelson, Elizabeth A Doro, M Anas Moughrabieh, Melissa R Partin
INTRODUCTION: The National Lung Screening Trial recently reported that annual low-dose computed tomography screening is associated with decreased lung cancer mortality in high-risk smokers. This study sought to identify the factors patients consider important in making lung cancer screening (LCS) decisions, and explore variations by patient characteristics and LCS participation. MATERIAL AND METHODS: This observational survey study evaluated the Minneapolis VA LCS Clinical Demonstration Project in which LCS-eligible Veterans (N=1388) were randomized to either Direct LCS Invitation (mailed with decision aid, N=926) or Usual Care (provider referral, N=462)...
February 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28212941/injections-of-the-of-the-%C3%AE-1-adrenoceptor-antagonist-prazosin-into-the-median-raphe-nucleus-increase-food-intake-and-fos-expression-in-orexin-neurons-of-free-feeding-rats
#15
Eduardo Simão da Silva, Rafael Appel Flores, Anderson Savaris Ribas, Ana Paula Taschetto, Moacir Serralvo Faria, Leandro Bueno Lima, Martin Metzger, José Donato, Marta Aparecida Paschoalini
Previously, we showed that the blockade of α1-adrenoreceptors in the median raphe nucleus (MnR) increased food intake in free-feeding rats, indicating that adrenergic mechanisms in the MnR participate in the regulation of food intake. However, the impact of such a pharmacological manipulation on other neural circuits related to food intake remains unknown. In the current study, we sought to identify forebrain regions which are responsive to α1-adrenergic receptor blockade and presumably involved in the modulation of the feeding response...
February 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28212879/flow-cytometric-based-protocols-for-assessing-anti-mt-2-igg1-reactivity-high-dimensional-data-handling-to-define-predictors-for-clinical-follow-up-of-human-t-cell-leukemia-virus-type-1-infection
#16
Jordana Grazziela Coelho-Dos-Reis, Vanessa Peruhype-Magalhães, Marcelo Antônio Pascoal-Xavier, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Ludmila Melo Cardoso, Juan Jonathan-Gonçalves, Ágata Lopes Ribeiro, Ana Lúcia Borges Starling, João Gabriel Ribas, Denise Utsch Gonçalves, Anna Bárbara de Freitas Carneiro-Proietti, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho
The present work provides an innovative methodological approach to assess the anti-HTLV-1 IgG1 reactivity with practical application in clinical laboratory. Serum from non-infected healthy controls (NI) and HTLV-1-infected patients, categorized as asymptomatic (AS), putatively progressing to HTLV-1 associated myelopathy/tropical spastic paraparesis - HAM/TSP (pHAM) or with clinical diagnosis of HAM/TSP (HT) were assayed in two-parallel flow cytometry platforms, referred as: Fix and Fix&Perm protocols. Operating-characteristics analysis indicated that a single pair of attributes ("serum dilution/cut-off") for Fix and Fix&Perm protocols presented excellent performance for the diagnosis of HTLV-1 infection...
February 14, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28212839/incidence-and-prognosis-of-nosocomial-infection-after-recovering-of-cardiac-arrest-in-children
#17
Andrés Fernández, Ana Solís, Paloma Cañete, Jimena Del Castillo, Javier Urbano, Angel Carrillo, Jesús López-Herce
OBJECTIVE: to analyze the incidence of infection in children who have suffered an in-hospital cardiac arrest (CA) and the association with mortality. METHODS: A retrospective unicenter observational study on a prospective database with children between one month and 16 years old, who have suffered an in-hospital CA was performed. Clinical, analytical and monitorization data, treatment, mortality and cause of death were recorded. RESULTS: 57 children were studied (57...
February 14, 2017: Resuscitation
https://www.readbyqxmd.com/read/28212811/polymorphisms-of-blood-forms-and-in-vitro-metacyclogenesis-of-trypanosoma-cruzi-i-ii-and-iv
#18
Camila Piva Abegg, Ana Paula de Abreu, Juliane Lopes da Silva, Silvana Marques de Araújo, Mônica Lúcia Gomes, Érika Cristina Ferreira, Max Jean de Ornelas Toledo
Trypanosoma cruzi is the etiologic agent of American trypanosomiasis has broad biological and genetic diversity. Remaining to be studied are polymorphisms of the blood forms and metacyclogenesis of different T. cruzi discrete typing units (DTUs). Our goal was to evaluate the relationship between T. cruzi DTUs, the morphology of blood trypomastigotes, and in vitro metacyclogenesis. T. cruzi strains that pertained to DTUs TcI, TcII, and TcIV from different Brazilian states were used. Parameters that were related to the morphology of eight strains were assessed in thin blood smears that were obtained from mice that were inoculated with blood or culture forms, depending on strain...
February 14, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28212611/impact-of-novel-snps-identified-in-cynara-cardunculus-genes-on-functionality-of-proteins-regulating-phenylpropanoid-pathway-and-their-association-with-biological-activities
#19
Ana Margarida Ferro, Patrícia Ramos, Olinda Guerreiro, Eliana Jerónimo, Inês Pires, Carmen Capel, Juan Capel, Rafael Lozano, Maria F Duarte, M Margarida Oliveira, Sónia Gonçalves
BACKGROUND: Cynara cardunculus L. offers a natural source of phenolic compounds with the predominant molecule being chlorogenic acid. Chlorogenic acid is gaining interest due to its involvement in various biological properties such as, antibacterial, antifungal, antioxidant, hepatoprotective, and anticarcinogenic activities. RESULTS: In this work we screened a Cynara cardunculus collection for new allelic variants in key genes involved in the chlorogenic acid biosynthesis pathway...
February 17, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28212481/-workplace-bullying-during-specialty-training-in-a-pediatric-hospital-in-mexico-a-little-noticed-phenomenon
#20
Ana Carolina Sepúlveda-Vildósola, Alma Rebeca Mota-Nova, Germán Enrique Fajardo-Dolci, L Isabel Reyes-Lagunes
BACKGROUND: Workplace bullying (WB) is a hostile or intimidating behavior that is practiced against workers and has a negative impact on health, job performance, and the learning process. The objective was to research WB magnitude and its associated factors in Mexico. METHODS: Mixed method study. A survey was designed and administered to all the residents in a pediatric hospital in Mexico who agreed to participate. The survey was divided in two sections: a) resident self-reported events of workplace bullying and associated factors, b) situations and factors of abuse were interrogated in a targeted manner...
2017: Revista Médica del Instituto Mexicano del Seguro Social
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