keyword
https://read.qxmd.com/read/38501351/ambulatory-blood-pressure-after-12%C3%A2-weeks-of-quadruple-combination-of-quarter-doses-of-blood-pressure-medication-vs-standard-medication
#1
JOURNAL ARTICLE
Janis M Nolde, Emily Atkins, Simone Marschner, Graham S Hillis, John Chalmers, Laurent Billiot, Mark R Nelson, Christopher M Reid, Peter Hay, Michael Burke, Shirley Jansen, Tim Usherwood, Anthony Rodgers, Clara K Chow, Markus P Schlaich
BACKGROUND: A combination of four ultra-low-dose blood pressure (BP) medications lowered office BP more effectively than initial monotherapy in the QUARTET trial. The effects on average ambulatory BP changes at 12 weeks have not yet been reported in detail. METHODS: Adults with hypertension who were untreated or on monotherapy were eligible for participation. Overall, 591 participants were randomized to either the quadpill (irbesartan 37.5 mg, amlodipine 1...
February 29, 2024: Journal of Hypertension
https://read.qxmd.com/read/38422674/application-of-electron-paramagnetic-resonance-spectroscopy-to-examine-free-radicals-formed-in-indapamide-and-torasemide-storage-under-uv-irradiation-and-at-the-higher-temperatures-which-appear-under-light-exposition
#2
JOURNAL ARTICLE
Kinga Orlińska, Paweł Ramos, Katarzyna Komosińska-Vassev, Krystyna Olczyk, Jerzy Stojko, Anna Rzepecka-Stojko, Yoana Kiselova-Kaneva, Diana Ivanova, Paweł Olczyk, Barbara Pilawa
Free radical formation in two diuretics: indapamide and torasemide was examined during UV irradiation and storage at higher temperatures using X-band (9.3 GHz) electron paramagnetic resonance spectroscopy (EPR). The aim of this study was to investigate the possibility of storing indapamide and torasemide under UV irradiation and at higher temperatures, which may occur during exposure to light. The diuretic samples were exposed to UVA irradiation for 15, 30 and 45 minutes, and stored at temperatures of 40 ° C and 50 ° C by 30 minutes...
February 22, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38389023/-not-available
#3
JOURNAL ARTICLE
Redaktion Facharztmagazine
No abstract text is available yet for this article.
February 2024: MMW Fortschritte der Medizin
https://read.qxmd.com/read/38371656/rationale-for-a-new-low-dose-triple-single-pill-combination-for-the-treatment-of-hypertension
#4
JOURNAL ARTICLE
Anthony Rodgers, Abdul Salam, William Cushman, Asita de Silva, Gian Luca Di Tanna, Sonali R Gnanenthiran, Diederick Grobbee, Krzysztof Narkiewicz, Dike Ojji, Suzanne Oparil, Neil Poulter, Markus P Schlaich, Aletta E Schutte, Wilko Spiering, Bryan Williams, Jackson T Wright, Paul Whelton
Two recent large trials showed the potential of single pill combinations (SPCs) with ≥3 low-dose components among people with hypertension who were untreated or receiving monotherapy. In both trials, these 'hypertension polypills' were superior to usual care, achieving >80% BP control without increasing withdrawal due to side effects. However, there are no such products available for prescribers. To address this unmet need, George Medicines developed GMRx2 with telmisartan/amlodipine/indapamide in three strengths (mg): 10/1...
2024: Global Heart
https://read.qxmd.com/read/38319613/effects-of-allisartan-isoproxil-based-combination-antihypertensive-regimen-in-hypertensive-patients-with-microalbuminuria-or-hyperuricemia
#5
JOURNAL ARTICLE
Ningling Sun, Hongyi Wang
Microalbuminuria and hyperuricemia management are crucial for the integrated management of hypertensive patients. This retrospective post hoc analysis aims to evaluate the optimal allisartan-isoproxil-based combination regimen for hypertensive patients with microalbuminuria or hyperuricemia. A total of 460 hypertensive patients with microalbuminuria and 486 hypertensive patients with hyperuricemia were included in this study. All patients were initially treated with allisartan-isoproxil for 4 weeks. Thereafter, patients with blood pressure (BP) < 140/90 mmHg continued the monotherapy for 8 weeks; patients with BP ≥140/90 mmHg were randomly assigned in a 1:1 ratio to receive allisartan-isoproxil + amlodipine (Group A + C) or allisartan-isoproxil + indapamide (Group A + D) for 8 weeks...
February 6, 2024: Journal of Clinical Hypertension
https://read.qxmd.com/read/38318257/demonstrating-the-benefits-of-antihypertensive-nighttime-dosing-and-indapamide-usage-in-hypertension-management
#6
JOURNAL ARTICLE
Jonathan S Newsome
Background: Uncontrolled hypertension, specifically nocturnal hypertension, increases the risk for significant clinical outcomes. Evidence on the use of nighttime antihypertensives is scant and conflicting. In addition, hydrochlorothiazide continues to be the primary thiazide used despite being the least potent. Objective: The primary purpose of this study was to evaluate instituting nighttime dosing to control hypertension and compare the short-term effectiveness of blood pressure control with indapamide versus hydrochlorothiazide...
February 2024: Journal of Pharmacy Technology: JPT: Official Publication of the Association of Pharmacy Technicians
https://read.qxmd.com/read/38296559/in-silico-prediction-of-n-nitrosamine-formation-pathways-of-pharmaceutical-products
#7
JOURNAL ARTICLE
Genichiro Tsuji, Takashi Kurohara, Takuji Shoda, Hidetomo Yokoo, Takahito Ito, Sayaka Masada, Nahoko Uchiyama, Eiichi Yamamoto, Yosuke Demizu
The recent discovery of N-nitrosodimethylamine (NDMA), a mutagenic N-nitrosamine, in pharmaceuticals has adversely impacted the global supply of relevant pharmaceutical products. Contamination by N-nitrosamines diverts resources and time from research and development or pharmaceutical production, representing a bottleneck in drug development. Therefore, predicting the risk of N-nitrosamine contamination is an important step in preventing pharmaceutical contamination by DNA-reactive impurities for the production of high-quality pharmaceuticals...
2024: Chemical & Pharmaceutical Bulletin
https://read.qxmd.com/read/38274913/machine-learning-insights-into-uric-acid-elevation-with-thiazide-therapy-commencement-and-intensification
#8
JOURNAL ARTICLE
Murat Özdede, Alper T Guven
Background Elevated serum uric acid, associated with cardiovascular conditions such as atherosclerotic heart disease, hypertension, and heart failure, can be elevated by thiazide or thiazide-like drugs (THZ), essential in hypertension management. Identifying clinical determinants affecting THZ-related uric acid elevation is critical. Methods In this retrospective cross-sectional study, we explored the clinical determinants influencing uric acid elevation related to THZ, focusing on patients where THZ was initiated or the dose escalated...
December 2023: Curēus
https://read.qxmd.com/read/38223870/perindopril-indapamide-induced-photosensitivity
#9
JOURNAL ARTICLE
Chaker Ben Salem, Dhouha Sahnoun, Hanen Zayani, Roudha Slim, Mohamed Denguezli
No abstract text is available yet for this article.
February 2024: Hospital Pharmacy
https://read.qxmd.com/read/38218924/initial-treatment-with-a-single-capsule-containing-half-dose-quadruple-therapy-versus-standard-dose-dual-therapy-in-hypertensive-patients-quadual-statistical-analysis-plan-for-a-randomized-blinded-crossover-trial
#10
RANDOMIZED CONTROLLED TRIAL
Xiexiong Zhao, Xingli Li, Tao Liu, Guoping Yang, Ye Chen, Miao Huang, Lin Zhao, Xiaogang Li, Weihong Jiang
BACKGROUND: Combined antihypertensive therapy has obvious advantages over single drug therapy. Hypertension guidelines fully affirm the efficacy of dual combination in initial antihypertensive therapy. Recent studies have also pointed out that the quadruple combination of very low-dose antihypertensive drugs is superior to single drugs. However, whether low-dose quadruple therapy is better than dual combination is unknown. METHODS/DESIGN: A randomized double-blind crossover clinical trial will be conducted to compare the efficacy and safety of low-dose quadruple antihypertensives (irbesartan 75 mg + metoprolol 23...
January 13, 2024: Trials
https://read.qxmd.com/read/38204501/diuretic-strategies-in-acute-decompensated-heart-failure-a-narrative-review
#11
REVIEW
Ben J Wilson, Duane Bates
BACKGROUND: Heart failure is a common condition with considerable associated costs, morbidity, and mortality. Patients often present to hospital with dyspnea and edema. Inadequate inpatient decongestion is an important contributor to high readmission rates. There is little evidence concerning diuresis to guide clinicians in caring for patients with acute decompensated heart failure. Contemporary diuretic strategies have been defined by expert opinion and older landmark clinical trials...
2024: Canadian Journal of Hospital Pharmacy
https://read.qxmd.com/read/38088116/-efficacy-and-organoprotection-of-triple-combinations-in-the-treatment-of-arterial-hypertension
#12
JOURNAL ARTICLE
E V Serdechnaya
The 2022 draft Russian guidelines on arterial hypertension recommend initiation of antihypertensive therapy with a combination of drugs in most patients with blood pressure above 150 / 90 mm Hg and / or in the presence of high-risk criteria. In 2021, the results of a 12-year analysis of the Brisighella Heart Study (BHS) were published. The aim of this study was to compare the use of different triple antihypertensive drug combinations in an Italian cohort of patients in real-life clinical practice...
December 5, 2023: Kardiologiia
https://read.qxmd.com/read/37895227/a-spanish-family-with-gordon-syndrome-due-to-a-variant-in-the-acidic-motif-of-wnk1
#13
JOURNAL ARTICLE
Ramón Peces, Carlos Peces, Laura Espinosa, Rocío Mena, Carolina Blanco, Jair Tenorio-Castaño, Pablo Lapunzina, Julián Nevado
(1) Background: Gordon syndrome (GS) or familial hyperkalemic hypertension is caused by pathogenic variants in the genes WNK1 , WNK4 , KLHL3, and CUL3 . Patients presented with hypertension, hyperkalemia despite average glomerular filtration rate, hyperchloremic metabolic acidosis, and suppressed plasma renin (PR) activity with normal plasma aldosterone (PA) and sometimes failure to thrive. GS is a heterogeneous genetic syndrome, ranging from severe cases in childhood to mild and sometimes asymptomatic cases in mid-adulthood...
September 27, 2023: Genes
https://read.qxmd.com/read/37814929/pharmacokinetics-and-drug-drug-interaction-of-allisartan-isoproxil-and-indapamide-sustained-release-formulation
#14
JOURNAL ARTICLE
Wu Yi, Sisi Lin, Rui Hao, Yiming Shao, Yannan Wang, Jin Yu, Lu Fang, Jingjing Zhu, Aiwei Wang, Yanfang Wu, Hua Huang, Chongyang Deng, Jingchao Sun, Hongcan Zhao, Ying Wang, Xiangming Tong
Allisartan isoproxil (AI) is an angiotensin II type 1 receptor blocker and be converted into the active substance EXP3174 in vivo. We evaluated the drug-drug interactions of AI and an indapamide sustained-release (Ind SR) preparation, as well as the pharmacokinetic characteristics and safety of AI and Ind SR in healthy subjects. The trial was set up in 6 sequences and 3 cycles, and each cycle contained a 7-day washout period. Subjects received 3 different trial drugs (A, AI; B, Ind SR; C, AI + Ind SR) during 3 different cycles...
October 10, 2023: Clinical Pharmacology in Drug Development
https://read.qxmd.com/read/37775279/external-auditory-canal-sebaceous-carcinoma
#15
JOURNAL ARTICLE
Sara A Assiri, Rahaf Ghazi Altwairqi, Raneem Alotaibi, Mohammed Ibrahim
The incidence of sebaceous carcinoma (SC) in the outer one-third of the external auditory canal is considered extremely rare, and only eight case reports have been published. We present a case of a male patient in his late 70s known case of hypertension on indapamide. His medical history included a postspinal tumour that had been treated with surgery and radiation more than 40 years ago and current complaints of right ear pain and purulent discharge. A right ear soft granular tissue mass was found. Complete debulking of the right ear mass was done in conjunction with middle ear exploration, moderately differentiated SC diagnosis was made based on the histopathological analysis...
September 29, 2023: BMJ Case Reports
https://read.qxmd.com/read/37765312/physical-ageing-of-amorphous-poly-lactic-acid-indapamide-system-studied-by-differential-scanning-calorimetry
#16
JOURNAL ARTICLE
Marcin Skotnicki, Agata Drogoń, Janina Lulek, Marek Pyda
The process of isothermal and non-isothermal physical ageing of amorphous polylactide (PLA) with the active pharmaceutical ingredient, indapamide (IND), was investigated. A PLA-IND system with a 50/50 weight ratio was obtained and characterized using differential scanning calorimetry (DSC). In the 50/50 ( w / w ) mixture, two glass transitions were observed: the first at 64.1 ± 0.3 °C corresponding to the glass transition temperature ( T g ) of PLA, and the second at 102.6 ± 1.1 °C corresponding to the T g of IND, indicating a lack of molecular mixing between the two ingredients...
September 19, 2023: Pharmaceutics
https://read.qxmd.com/read/37728093/a-real-world-analysis-of-outcomes-and-healthcare-costs-of-patients-on-perindopril-indapamide-amlodipine-single-pill-vs-multiple-pill-combination-in-italy
#17
JOURNAL ARTICLE
Jacques R Snyman, Luiz Aparecido Bortolotto, Luca Degli Esposti, Pathiyil Balagopalan Jayagopal, Alexandra O Konradi, Valentina Perrone, Claudio Borghi
OBJECTIVES: This analysis compared adherence, cardiovascular (CV) events and all-cause mortality incidence, and healthcare costs among hypertensive patients treated with perindopril (PER)/indapamide (IND)/amlodipine (AML) in single-pill combination (SPC) vs. multiple-pill combination, in a real-world setting in Italy. METHODS: In this observational retrospective analysis of Italian administrative databases, adult patients treated with PER/IND/AML between 2010 and 2020 were divided into two cohorts: single-pill vs...
January 1, 2024: Journal of Hypertension
https://read.qxmd.com/read/37693779/diethyl-2-2-2-chloro-5-2-eth-oxy-2-oxoeth-yl-2-methyl-indolin-1-yl-carbamo-yl-phen-yl-sulfon-yl-aza-nedi-yl-di-acetate
#18
JOURNAL ARTICLE
Youssef Ramli, Wedad Al Garadi, Mohamed El Hafi, Elghayati Lhoussaine, El Mokhtar Essassi, Abdulsalam Alsubari, Joel T Mague
The majority of the title mol-ecule, C28 H34 ClN3 O9 S, is disordered over two closely spaced sets of sites; the site occupancy of the major component = 0.542 (3). The conformation of each component is approximately U-shaped with the chloro-benzene ring forming the base and the indolinyl and sulfamoyl groups the sides; an intra-molecular C-H⋯Cl hydrogen bond possibly contributes to the stabilization of the conformation. In the crystal, a corrugated layer structure parallel to the ab plane is formed by C-H⋯O and C-H⋯Cl hydrogen bonds together with C-H⋯π(ring) inter-actions...
August 2023: IUCrData
https://read.qxmd.com/read/37691309/comparison-of-pharmacokinetics-and-bioavailability-of-fixed-dose-combination-tablet-and-monotherapy-combination-of-allisartan-isoproxil-and-indapamide-sustained-release-in-healthy-chinese-volunteers
#19
JOURNAL ARTICLE
Ni Fan, Zhou Gongmin, Cheng Wenming, Yang Jiao, Zhang Ruijie, Chen Yan, Tong Xiangming, Wu Yi
This study aimed to compare the pharmacokinetics and bioavailability of 2 formulations: a fixed-dose combination tablet containing allisartan isoproxil (AI) and indapamide sustained-release (SR), and a monotherapy combination of AI and indapamide SR, in healthy Chinese subjects. A monocentric, open-label, single-dose, randomized, 2-way crossover study design was implemented. A total of 38 healthy male and female volunteers were equally divided into 2 treatment sequences. The analysis of plasma concentrations was conducted using a nonstereospecific liquid chromatography/tandem mass spectrometric method...
September 10, 2023: Clinical Pharmacology in Drug Development
https://read.qxmd.com/read/37634155/-one-year-persistence-of-renin-angiotensin-aldosterone-system-inhibitors-fixed-drug-combinations-in-hypertensive-patients
#20
JOURNAL ARTICLE
Gábor Simonyi, Tamás Ferenci, Ervin Finta, Mihály Medvegy, István Wittmann
INTRODUCTION: Various fixed combinations of antihypertensive agents are highlighted in European and Hungarian hypertension guidelines. A renin-angiotensin-aldosterone system antagonist (RAAS inhibitor) in combination with calcium channel blockers (CCBs) or diuretics are recommended as the first step in antihypertensive therapy. OBJECTIVES: The aim of the authors was to compare the one-year persistence of RAAS inhibitor fixed-dose combinations (FDCs) in hypertension...
August 27, 2023: Orvosi Hetilap
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