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Ovarian reserve

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https://www.readbyqxmd.com/read/28548451/molecular-and-functional-characterization-of-the-american-cockroach-periplaneta-americana-rab5-the-first-exopterygotan-low-molecular-weight-ovarian-gtpase-during-oogenesis
#1
Mohamed Elmogy, Amr A Mohamed, Muhammad Tufail, Tomohide Uno, Makio Takeda
The small Rab GTPases are key regulators of membrane vesicle trafficking. Ovaries of Periplaneta americana (Linnaeus) (Blattodea: Blattidae) have small molecular weight GTP/ATP-binding proteins during early and late vitellogenic periods of oogenesis. However, the identification and characterization of the detected proteins have not been yet reported. Herein, we cloned a cDNA encoding Rab5 from the American cockroach, P. americana, ovaries (PamRab5). It comprises 796 bp, encoding a protein of 213 amino acid residues with a predicted molecular weight of 23...
May 26, 2017: Insect Science
https://www.readbyqxmd.com/read/28548227/changing-the-risk-threshold-for-surgical-prevention-of-ovarian-cancer
#2
Ranjit Manchanda, Rosa Legood, Antonis C Antoniou, Leigh Pearce, Usha Menon
Ovarian cancer (OC) remains a lethal disease and a major cause of deaths from gynaecological cancer particularly in western countries. Despite advances in treatment, there have been only marginal improvements in survival rates over the last 30years. Additionally, the number of OC cases in the UK is estimated to increase by 27-45%, which translates to a 15% rise in the incidence rate by 2035.(1) A national OC screening programme is unavailable as this has not yet shown a conclusive mortality benefit.(2) Hence, primary prevention continues to be the cornerstone in reducing the burden of OC and improving health outcomes...
May 26, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28546821/evaluation-of-neutrophil-lymphocyte-ratio-platelet-lymphocyte-ratio-and-red-blood-cell-distribution-width-platelet-ratio-for-diagnosis-of-premature-ovarian-insufficiency
#3
Gulsah Ilhan, Fatma Ferda Verit Atmaca, Esra Altan, Ali Galip Zebitay, Hamdullah Sozen, Hurkan Akyol, Meryem Kurek Eken
Objective: To evaluate whether systemic inflammatory markers (neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and red blood cell distribution width (RDW) to platelet ratio (RPR)) can be used as reliable markers for the diagnosis of premature ovarian insufficiency (POI) and to determine if there is a relationship between these markers and follicle stimulating hormone (FSH), Anti-Müllerian Hormone (AMH) levels. Materials and methods: Written and electronic medical records were reviewed using searches for diagnoses with the terms of 'premature ovarian failure', 'premature ovarian insufficiency'...
December 2016: Journal of Family & Reproductive Health
https://www.readbyqxmd.com/read/28543997/the-mutational-frequency-of-braf-and-kras-in-low-grade-serous-testicular-neoplasms-a-case-series
#4
Paidamwoyo Gwiti, Ildikó Vereczkey, David Cundell, Shazia Aslam, Tim Clench, Jeremy Braybrooke, Muhammed Sohail, Zsombor Melegh
AIMS: Low grade serous neoplasms of the testis are rare neoplasms that demonstrate striking morphological similarities with the better-understood ovarian neoplasms. The cell of origin, relation to serous ovarian tumour and the pathogenesis of these neoplasms are not fully established. METHODS AND RESULTS: As low grade serous ovarian neoplasms are known to harbour mutations in the MAP-kinase pathway, we investigated the involvement of BRAF and KRAS mutations in low grade testicular serous tumour by way of mutational analysis of 7 cases...
May 19, 2017: Histopathology
https://www.readbyqxmd.com/read/28543550/polycystic-ovary-morphology-is-associated-with-insulin-resistance-in-women-with-polycystic-ovary-syndrome
#5
So-Hyeon Hong, Yeon-Ah Sung, Young Sun Hong, Kyungah Jeong, Hyewon Chung, Hyejin Lee
BACKGROUND/OBJECTIVES: Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterised by chronic anovulation, hyperandrogenenism, polycystic ovary morphology (PCOM), and metabolic disturbances including insulin resistance and type 2 diabetes mellitus. Although insulin resistance could be associated with PCOM, recent studies have shown controversial results. The aim of this study was to determine the relationship between PCOM and insulin resistance. SUBJECTS/METHODS: This was a cross-sectional clinical study...
May 20, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28542798/glut-1-receptor-expression-and-circulating-levels-of-fasting-glucose-in-high-grade-serous-ovarian-cancer
#6
L Pizzuti, D Sergi, Chiara Mandoj, B Antoniani, Francesca Sperati, Andrea Chirico, Luigi Di Lauro, Mario Valle, Alfredo Garofalo, Enrico Vizza, Gabriele Corrado, Federica Tomao, Massimo Rinaldi, Silvia Carpano, M Maugeri-Saccà, Laura Conti, Giovanna Digiesi, Paolo Marchetti, Ruggero De Maria, A Giordano, Maddalena Barba, Maria Antonietta Carosi, Patrizia Vici
In recent years, the poorly remarkable goals achieved in terms of patients' important outcomes for ovarian cancer have fueled our interest towards the study of its metabolic roots. Within this research pipeline, we assessed the association between the expression of the glucose transporter GLUT1, as expressed at the tumor tissue level, and circulating pre-surgical levels of fasting glucose in a case series including data from 40 patients with high FIGO stage serous ovarian cancer. Patients who provided data to the current analysis were randomly selected from a larger cohort...
May 20, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28542265/ovarian-features-in-white-tailed-deer-odocoileus-virginianus-fawns-and-does
#7
G D A Gastal, A Hamilton, B G Alves, S G S de Tarso, J M Feugang, W J Banz, G A Apgar, C K Nielsen, E L Gastal
The knowledge about ovarian reserve is essential to determine the reproductive potential and to improve the methods of fertility control for overpopulated species, such as white-tailed deer (Odocoileus virginianus). The goal of this study was to evaluate the effect of age on the female reproductive tract of white-tailed deer, focusing on ovarian features. Genital tracts from 8 prepubertal and 10 pubertal females were used to characterize the preantral follicle population and density, morphology, distribution of follicular classes; stromal cell density; and apoptosis in the ovary...
2017: PloS One
https://www.readbyqxmd.com/read/28542147/restricting-the-induction-of-ngf-in-ovarian-stroma-engenders-selective-follicular-activation-through-the-mtor-signaling-pathway
#8
Yuanlin He, Xiaoxu Peng, Tinghe Wu, Weijie Yang, Wenwen Liu, Jing Zhang, Yiping Su, Feifei Kong, Xiaowei Dou, Jing Li
In mammalian ovaries, primordial follicles remain in a quiescent state until activation by the surrounding microenvironment. Ovarian intervention, for example, ovarian cystectomy, ovarian wedge resection or laser drilling therapies for polycystic ovarian syndrome, has long been reported to change follicular development by an unknown mechanism(s). Herein, we established a murine model with partial ovarian resection of one ovary unilaterally, with the contralateral ovary undamaged. We found the injury accelerated follicular activation and development through the mTORC1 signaling pathway...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28539163/a-quantitative-comparison-of-anti-m%C3%A3-llerian-hormone-measurement-and-its-shifting-boundaries-between-two-assays
#9
A C de Kat, F J M Broekmans, A C van Westing, E Lentjes, W M M Verschuren, Y T van der Schouw
OBJECTIVE: Anti-Müllerian hormone (AMH), a quantitative marker of ovarian reserve, is used for both clinical and research purposes in the field of reproductive medicine. Numerous AMH assays have been developed. Among other factors, the lack of large-scale comparisons of the various assays hinders the universal interpretation of AMH levels. Moreover, little is known of the practical performance of highly sensitive assays compared with conventional assays with regard to the very low AMH levels found in women nearing menopause...
July 2017: Maturitas
https://www.readbyqxmd.com/read/28538364/thalidomide-results-in-diminished-ovarian-reserve-in-reproductive-age-female-ibd-patients
#10
Xiang Peng, Min Zhi, Ming Wei, Ting-Ting Li, Min Zhang, Yuan-Qi Zhang, Huan He, Mingli Su, Wei Wang, Jun-Rong Chen, Jian Tang, Xiang Gao, Pin-Jin Hu, Xiao-Yan Liang
The effectiveness of thalidomide in treating inflammatory bowel disease (IBD) has been widely recognized. Meanwhile, many serious adverse drug reactions have been observed, but no know reports on ovarian reserve function.Female patients, ranging in age between 18 and 40, were referred to our institution to undergo sex hormone detection and ultrasonic scanning for ovarian function assessment, between February 1, 2016 and September 31, 2016.Thirty-three patients treated with thalidomide (group A), 73 patients without thalidomide (group B), and 78 healthy women as control were studied...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28518216/queen-presence-mediates-the-relationship-between-collective-behavior-and-disease-susceptibility-in-ant-colonies
#11
Carl N Keiser, Svjetlana Vojvodic, Imani O Butler, Elizabeth Sartain, Volker H W Rudolf, Julia B Saltz
The success of social living can be explained, in part, by a group's ability to execute collective behaviors unachievable by solitary individuals. However, groups vary in their ability to execute these complex behaviors, often because they vary in their phenotypic composition. Group membership changes over time due to mortality or emigration, potentially leaving groups vulnerable to ecological challenges in times of flux. In some societies, the loss of important individuals (e.g., leaders, elites, queens) may have an especially detrimental effect on groups' ability to deal with these challenges...
May 18, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28513833/potential-role-and-prognostic-importance-of-dishevelled-2-in-epithelial-ovarian-cancer
#12
Rong Liu, Jialin Cheng, Yannan Chen, Wei Wang, Jie Chen, Guoxin Mao
OBJECTIVE: To investigate the role and prognostic importance of Dvl2 in human epithelial ovarian cancer (EOC). METHODS: A multimethod study was undertaken including patients with pathologically confirmed non-metastatic EOC who underwent surgery for maximum tumor resection at a center in China. Dvl2 expression was assessed by western blot using fresh EOC tissues and normal ovarian tissues obtained between June 2014 and January 2015. Additionally, retrospective data were obtained for patients treated between April 2004 and September 2009...
May 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28510291/associations-between-rna-splicing-regulatory-variants-of-stemness-related-genes-and-racial-disparities-in-susceptibility-to-prostate-cancer
#13
Yanru Wang, Jennifer A Freedman, Hongliang Liu, Patricia G Moorman, Terry Hyslop, Daniel J George, Norman H Lee, Steven R Patierno, Qingyi Wei
Evidence suggests that cells with a stemness phenotype play a pivotal role in oncogenesis, and prostate cells exhibiting this phenotype have been identified. We used two genome-wide association study (GWAS) datasets of African descendants, from the Multiethnic/Minority Cohort Study of Diet and Cancer (MEC) and the Ghana Prostate Study, as well as two GWAS datasets of non-Hispanic whites, from the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial and the Breast and Prostate Cancer Cohort Consortium (BPC3), to analyze the associations between genetic variants of stemness-related genes and racial disparities in susceptibility to prostate cancer...
May 16, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28506797/-systematic-proposal-of-fertility-preservation-by-mature-oocyte-cryopreservation-for-recurrent-benign-ovarian-tumors
#14
Y Dadoun, H Azaïs, L Keller, E d'Orazio, P Collinet, C Decanter
OBJECTIVES: To investigate prospectively the pattern of the follicular growth and to characterize the COH outcome in terms of oocyte number and maturity in patients with voluminous recurrent benign ovarian tumors with a high surgical risk of significant reduction of the ovarian follicular content. METHODS: The inclusion criteria were: age between 18 and 36, presence of at least one benign ovarian tumor (≥ 5cm) with high risk of recurrence. The fertility preservation cycle was performed at least 3 months after the cyst surgery...
May 12, 2017: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/28506471/genetics-of-gonadotropins-and-their-receptors-as-markers-of-ovarian-reserve-and-response-in-controlled-ovarian-stimulation
#15
REVIEW
Laura Riccetti, Francesco De Pascali, Lisa Gilioli, Daniele Santi, Giulia Brigante, Manuela Simoni, Livio Casarini
Several controlled ovarian stimulation (COS) protocols have been developed to increase the yield of mature oocytes retrieved in assisted reproductive techniques (ARTs). The ovarian reserve (OR) influences the COS response, and it represents the main parameter that helps clinicians in refining clinical treatments in the perspective of a "personalized" ART. This approach is even more needed in particular conditions such as poor OR or polycystic ovary syndrome. Follicle-stimulating hormone, luteinizing hormone, and human chorionic gonadotropin are currently used in COS at different combinations and with different efficacies, even if the best approach definition is controversial...
April 17, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28504421/bioinformatics-analysis-on-molecular-mechanism-of-green-tea-compound-epigallocatechin-3-gallate-against-ovarian-cancer
#16
S Xinqiang, Z Mu, C Lei, L Y Mun
Epigallocatechin-3-gallate (EGCG) is the most abundant and biologically active catechin in green tea, and it exerts multiple effects in humans through mechanisms that remain to be clarified. The present study used bioinformatics to identify possible mechanisms by which EGCG reduces the risk of ovarian cancer. Possible human protein targets of EGCG were identified in the PubChem database, possible human gene targets were identified in the National Center for Biotechnology Information database, and then both sets of targets were analyzed using Ingenuity Pathway Analysis (IPA)...
May 15, 2017: Clinical and Translational Science
https://www.readbyqxmd.com/read/28502234/a-gonadotropin-releasing-hormone-agonist-for-the-prevention-of-docetaxel-induced-gonadal-damage
#17
Ilhae Park, Sanghoon Lee, Ki-Jin Ryu, Kyung-Jin Min, Jin Hwa Hong, Jae Yun Song, Jae Kwan Lee, Nak Woo Lee
This study aimed to evaluate the protective effect of a gonadotropin-releasing hormone (GnRH) agonist against docetaxel-induced gonadotoxicity in a mouse model. Forty mice (female B6, 6-8 weeks old, weighing 16-18 g) were divided randomly into four groups. Groups 1 and 2 were treated with a single intraperitoneal dose of 0.1 mL normal saline; Groups 3 and 4 received 30 mg/kg docetaxel. Groups 2 and 4 were pre-treated with a subcutaneous injection of 0.3 mg leuprolide acetate, 2 weeks before the administration of docetaxel...
May 14, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28502078/dyrk2-is-a-suppressor-and-potential-prognostic-marker-for-liver-metastasis-of-colorectal-cancer
#18
Daisuke Ito, Satomi Yogosawa, Rei Mimoto, Shinichi Hirooka, Takashi Horiuchi, Ken Eto, Katsuhiko Yanaga, Kiyotsugu Yoshida
Colorectal cancer is a common cancer and a leading cause of cancer-related death worldwide. The liver is a dominant metastatic site for patients with colorectal cancer. Molecular mechanisms that allow colorectal cancer cells to form liver metastases are largely unknown. Activation of epithelial-mesenchymal-transition (EMT) is the key step for metastasis of cancer cells. We have recently demonstrated in breast cancer and ovarian serous adenocarcinoma that dual-specificity tyrosine-regulated kinase 2 (DYRK2) controls EMT...
May 14, 2017: Cancer Science
https://www.readbyqxmd.com/read/28501984/pediatric-gynecologic-cancers
#19
REVIEW
Lauren Pommert, William Bradley
PURPOSE OF REVIEW: Three primary categories of gynecologic cancer are found in pediatric and adolescent patients: stromal carcinomas including juvenile granulosa cell tumors and Sertoli-Leydig cell tumors, rhabdomyosarcomas arising from the vagina and cervix (sarcoma botryoides), and ovarian germ cell tumors which comprise a wide range of histologies. These entities are rare and treatment approaches have focused on decreasing late effects of chemotherapy treatment. Here, we review presentation, histologic classifications, diagnosis, and treatment recommendations for pediatric gynecologic cancers...
July 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28498960/which-is-worse-comparison-of-art-outcome-between-women-with-primary-or-recurrent-endometriomas
#20
Baris Ata, Sezcan Mumusoglu, Kiper Aslan, Ayse Seyhan, Isil Kasapoglu, Berrin Avci, Bulent Urman, Gurkan Bozdag, Gurkan Uncu
STUDY QUESTİON: Are live birth rates (LBR) different after ART cycles between women with primary or recurrent endometrioma? SUMMARY ANSWER: Women with recurrent endometrioma have similar LBR as compared to patients with primary endometrioma. WHAT IS ALREADY KNOWN: Recurrence rate can be as high as 29% after endometrioma excision. Prior studies on management of endometrioma before ART involve primary endometriomas. There is limited information regarding the prognosis of women with recurrent endometriomas...
May 12, 2017: Human Reproduction
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