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Ovarian reserve

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https://www.readbyqxmd.com/read/27909567/ovarian-reserve-may-be-compromised-after-adnexal-surgery-are-we-sufficiently-fertility-focused-in-our-surgical-training
#1
G S Kalra, S Campbell, G Nargund
There is a general trend towards delay in childbearing age amongst women. The ovarian reserve clearly falls with increasing age and the impact is greater with advancing age, particularly from late 30s. Presence of other risk factors can increase the risk of subfertility. A large number of women are exposed to pelvic surgery for various reasons, both elective and emergency. There is evidence that some of the pelvic surgery performed around ovaries and tubes has a negative impact on the ovarian reserve and in turn may cause a decline in woman's ability to conceive...
June 27, 2016: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/27907901/serum-amh-levels-in-healthy-women-from-brca1-2-mutated-families-are-they-reduced
#2
Theodora C van Tilborg, Inge A P Derks-Smeets, Anna M E Bos, Jan C Oosterwijk, Ron J van Golde, Christine E de Die-Smulders, Lizet E van der Kolk, Wendy A G van Zelst-Stams, Maria E Velthuizen, Annemieke Hoek, Marinus J C Eijkemans, Joop S E Laven, Margreet G E M Ausems, Frank J M Broekmans
STUDY QUESTION: Do BRCA1/2 mutation carriers have a compromised ovarian reserve compared to proven non-carriers, based on serum anti-Müllerian hormone (AMH) levels? SUMMARY ANSWER: BRCA1/2 mutation carriers do not show a lower serum AMH level in comparison to proven non-carriers, after adjustment for potential confounders. WHAT IS KNOWN ALREADY: It has been suggested that the BRCA genes play a role in the process of ovarian reserve depletion, although previous studies have shown inconsistent results regarding the association between serum AMH levels and BRCA mutation status...
November 2016: Human Reproduction
https://www.readbyqxmd.com/read/27906603/utility-of-ovarian-reserve-screening-with-anti-m%C3%A3-llerian-hormone-for-reproductive-age-women-deferring-pregnancy
#3
Lisa C Grossman, Lauren Zakarin Safier, Melissa D Kline, Cariann W Chan, Rogerio A Lobo, Mark V Sauer, Nataki C Douglas
BACKGROUND: Ovarian reserve (OR) testing with serum anti-Müllerian hormone (AMH) can provide information about a woman's fertility potential. The aim of this study was to assess interest and knowledge about OR testing and investigate the utility of measuring AMH in women of reproductive age deferring pregnancy. METHODS: Women ages 27-37 years currently delaying childbearing were invited to take a survey regarding attitudes and knowledge about OR testing before and after an AMH measurement with explanation of their results...
December 1, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27905697/management-of-infertile-women-with-pelvic-endometriosis-a-literature-review
#4
Elisabeth Guinard, Pierre Collinet, Catherine Lefebvre, Geoffroy Robin, Chrystele Rubod
INTRODUCTION: Endometriosis is a condition that affects women's fertility. Several mechanisms are involved in this process: anatomical changes, mechanical, immune or inflammatory factors, ovarian reserve alterations. There are different types of strategies to treat endometriosis-related infertility: medical treatment, surgical treatment and / or techniques of medically assisted procreation. EVIDENCE ACQUISITION: We tried to consider various therapeutic strategies depending on the stage of the disease in order to offer appropriate management to patients with endometriosis who wish to become pregnant: we reviewed 58 articles between 1985 to 2016 searching in medline using the key words "endometriosis and infertility" and "infertility and endometriosis treatment"...
December 1, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27905042/preventive-salpingectomy-and-ovarian-reserve-experimental-study
#5
I A Petrov, O A Tikhonovskaya, A O Okorokov, I I Kupriyanova, M S Petrova, S V Logvinov
The levels of anti-Müllerian hormone, follicle-stimulating hormone, and testosterone were studied in rats after removal of the uterine horns, oviducts, or combined surgery. The effects of preventive salpingectomy on ovarian reserve were studied. After preventive salpingectomy, the level of anti-Müllerian hormone was low throughout the experiment, follicle-stimulating hormone increased only by the end of observation (on day 40), and testosterone level decreased only on day 10. Hysterectomy alone caused no changes in the concentrations of the studied hormones on day 10 after surgery...
December 1, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27899313/prognostic-factors-for-assisted-reproductive-technology-in-women-with-endometriosis-related-infertility
#6
Chloé Maignien, Pietro Santulli, Vanessa Gayet, Marie-Christine Lafay-Pillet, Diane Korb, Mathilde Bourdon, Louis Marcellin, Dominique de Ziegler, Charles Chapron
BACKGROUND: Assisted reproductive technology is one of the therapeutic options offered for managing endometriosis-associated infertility. Yet, published data on assisted reproductive technology outcome in women affected by endometriosis are conflicting and the determinant factors for pregnancy chances unclear. OBJECTIVE: To evaluate assisted reproductive technology outcomes in a series of 359 endometriosis patients, to identify prognostic factors and determine if there is an impact of the endometriosis phenotype...
November 26, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27894151/value-of-the-ultrasound-in-the-study-of-ovarian-reserve-for-prediction-of-oocyte-recovery
#7
Meire Spressão, Antonio Hélio Oliani, Denise Cristina Mós Vaz Oliani
Purpose To identify which methods used in the assessment of the ovarian reserve are exclusive or complementary to identify the best response to follicle development. Methods Retrospective cohort study, involving patients undergoing assisted reproduction treatment at the Instituto de Medicina Reprodutiva e Fetal, from April 2009 to July 2014. Age, biochemical tests, and ultrasound were assessed. The data were analyzed to predict the follicular development and the relation between them, using, for statistical analysis, Statistical Package for Social Sciences software...
October 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/27891401/premature-ovarian-failure-an-association-with-autoimmune-diseases
#8
Ayesha, Vandana Jha, Deepti Goswami
INTRODUCTION: Premature Ovarian Failure (POF) is the cessation of ovarian function before the age of 40 years. POF is reported to be associated with autoimmune diseases in 20-30% of cases. AIM: Patients presenting with idiopathic POF were screened for the presence of autoimmune disorders. MATERIALS AND METHODS: Twenty patients with idiopathic POF were included in the study. Baseline investigation in all subjects included fasting serum FSH, LH, E2, progesterone, free T3, free T4, Thyroid-Stimulating Hormone (TSH) and Anti-Thyroperoxidase (anti-TPO) antibodies, testosterone and Dehydroepiandrosterone (DHEAS) levels...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890715/effects-of-atrazine-on-ovarian-growth-in-the-estuarine-crab-neohelice-granulata
#9
G R Silveyra, I S Canosa, E M Rodríguez, D A Medesani
Atrazine, a herbicide that is intensively used in Argentina, was assayed to evaluate the alteration of reproduction in a wild species of crustaceans. Adult females of the estuarine crab Neohelice granulata were exposed to formulated atrazine during the 3-month pre-reproductive period. Three atrazine concentrations (0.03, 0.3 and 3mg/L) were assayed, together with a water dilution control. At the end of the exposure period, several variables concerning the energetic status of animals were measured, such as weight gain, glycemia, and energy reserves in both muscle and hepatopancreas...
November 24, 2016: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/27889913/long-term-melatonin-treatment-delays-ovarian-aging
#10
Hiroshi Tamura, Mai Kawamoto, Shun Sato, Isao Tamura, Ryo Maekawa, Toshiaki Taketani, Hiromi Aasada, Eiichi Takaki, Akira Nakai, Russel J Reiter, Norihiro Sugino
Ovarian aging is characterized by gradual declines in oocyte quantity and quality. Melatonin is considered an anti-aging agent due to its cytoprotective actions as an antioxidant. The present study examined whether long-term melatonin treatment would delay ovarian aging in mice. Female ICR mice (10 weeks old) were given melatonin-containing water (100 μg/ml; melatonin) or water only until 43 weeks of age. Their oocytes were recovered from the oviduct, and in vitro fertilization was performed. The ovaries were used for a histological analysis of the number of follicles...
November 27, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27887709/impact-of-tamoxifen-therapy-on-fertility-in-breast-cancer-survivors
#11
Lisa M Shandley, Jessica B Spencer, Amy Fothergill, Ann C Mertens, Amita Manatunga, Elisavet Paplomata, Penelope P Howards
OBJECTIVE: To determine whether tamoxifen use is associated with decreased ovarian reserve and decreased likelihood of having a child after a breast cancer diagnosis, using data from the Furthering Understanding of Cancer, Health, and Survivorship in Adult (FUCHSIA) Women Study. DESIGN: Population-based cohort study. SETTING: Not applicable. PATIENT(S): Three hundred ninety-seven female breast cancer survivors aged 22-45 years whose cancer was diagnosed between ages 20 and 35 years and who were at least 2 years after diagnosis; 108 survivors also participated in a clinic visit...
November 22, 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27883256/detecting-agg-interruptions-in-male-and-female-fmr1-premutation-carriers-by-single-molecule-sequencing
#12
Simon Ardui, Valerie Race, Alena Zablotskaya, Matthew S Hestand, Hilde Van Esch, Koenraad Devriendt, Gert Matthijs, Joris R Vermeesch
The FMR1 gene contains an unstable CGG repeat in its 5' untranslated region. Premutation alleles range between 55 and 200 repeat units and confer a risk for developing fragile X-associated tremor/ataxia syndrome or fragile X-associated primary ovarian insufficiency. Furthermore, the premutation allele often expands to a full mutation during female germline transmission giving rise to the fragile X syndrome. The risk for a premutation to expand depends mainly on the number of CGG units and the presence of AGG interruptions in the CGG repeat...
November 24, 2016: Human Mutation
https://www.readbyqxmd.com/read/27882769/-current-issues-of-reproductive-medicine-in-the-czech-republic
#13
P Ventruba, J Žáková, M Ješeta, D Rumpík, M Brandejská, I Crha, D Hlinka, L Jelínková, E Oráčová, J Pavelková, K Řežábek, K Veselá
INTRODUCTION: During the 25th symposium of assisted reproduction in Brno was lunch time organised as the lunch table discussion on the selected topics of assisted reproduction. More than 150 specialists reviewed themes related to gynecology and embryology.Discussed topics: Lunch table discussion covered the following topics: (1) Cross-border health care in assisted reproduction; (2) Indication for PGS (preimplantation genetic screening) in the context of actual information; (3) Does ovarian stimulation belong to the ambulance of registering gynecologists? (4) Therapy with clomifen - only for IVF specialists? (5) How and with whom should psychological support be directed during IVF? (6) Stimulation in women with low ovarian reserve; (7) Is basic semen analyses sufficient? (8) Time-lapse systems as relevant markers of embryonic development; (9) How to be oriented with choices of media and consumables in the IVF lab, and (10) "Freeze All" - is this new trend in cryopreservation suitable for all? CONCLUSIONS: Panel conclusions were presented during the afternoon session, which had great attendance, featured lively commentary, and produced some definitive consensus...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27882760/-surgical-treatment-of-endometriomas-and-ovarian-reserve
#14
D Barátová, L Mekiňová, K Slabá, I Crha
OBJECTIVE: To present an overview of affect an ovarian reserve in women after laparoscopic surgery for ovarian endometriosis. SUBJECT: Review. SETTING: Department of Obstetric and Gynecology, Hospital Kyjov; Department of Obstetric and Gynecology, University Hospital, Brno. METHODS: Summary of the results of recent studies. RESULTS: The decrease in ovarian reserve has been detected in 8 of 9 evaluated studies, specifically in one retrospective study, six prospective studies and in one systematic review, the results of the meta-analysis don´t prove the reduction of ovarian reserve after the surgery for endometrioma, reduced ovarian reserve evaluated by the antral follicle count has been proven in the affect ovary before the surgery...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27880944/opportunistic-salpingectomy-does-not-affect-ovarian-reserve-or-surgical-outcomes-in-patients-undergoing-laparoscopic-myomectomy
#15
Taejong Song, San-Hui Lee, Woo Young Kim, Eun Jin Heo, Tae-Joong Kim
OBJECTIVE: To determine whether opportunistic salpingectomy in patients undergoing laparoscopic myomectomy has any deleterious effects on ovarian reserve and surgical risk. STUDY DESIGN: We performed a retrospective review of patients who had no desire for future child bearing and who were undergoing laparoscopic myomectomy for symptomatic myomas at 4 institutions. Among them, 41 patients concurrently underwent opportunistic salpingectomy (the opportunistic salpingectomy group) and 65 patients did not undergo salpingectomy at the time of laparoscopic myomectomy (the no-salpingectomy group)...
November 24, 2016: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/27879029/progesterone-receptor-and-prostaglandins-mediate-luteinizing-hormone-induced-changes-in-messenger-rnas-for-adamts-proteases-in-theca-cells-of-bovine-periovulatory-follicles
#16
E L Willis, P J Bridges, J E Fortune
Little is known about the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family of extracellular proteases in ovarian follicles of non-rodent species, particularly in theca cells. In the present study, temporal patterns of change in mRNA for four ADAMTS subtypes and the hormonal transcriptional regulation of two subtypes were investigated in theca cells during the periovulatory period in cattle. Follicles were obtained at 0 h post-gonadotropin-releasing hormone (GnRH; preovulatory) or at 6, 12, 18, or 24 h after injection of GnRH (periovulatory) to induce a luteinizing hormone (LH)/follicle-stimulating hormone surge...
November 23, 2016: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/27876427/fmr1-premutation-not-only-important-in-premature-ovarian-failure-but-also-in-diminished-ovarian-reserve
#17
Ali Eslami, Kamelia Farahmand, Mehdi Totonchi, Tahereh Madani, Ummulbanin Asadpour, Shabnam Zari Moradi, Hamid Gourabi, Anahita Mohseni-Meybodi
It is recognized that FMR1 premutation expansions are associated with premature ovarian failure (POF), but their role in diminished ovarian reserve (DOR) is not clearly established. Moreover, the impact of smaller repeats at the boundary of premutation and normal is less clear. Therefore, we have compared the frequency of these intermediate (45-54 repeats) and premutation (>55) sized FMR1 CGG repeats among a patients group including 188 DOR and 173 POF women and 200 controls. FSH and LH concentrations were also compared between intermediate and premutation ranges in patients...
November 23, 2016: Human Fertility: Journal of the British Fertility Society
https://www.readbyqxmd.com/read/27865943/association-between-parity-and-ovarian-reserve-in-reproductive-age-women
#18
Ashraf Moini, Manigeh Hedayatshodeh, Reihaneh Hosseini, Hadith Rastad
OBJECTIVE: A number of factors affect ovarian reserve. In this study, we investigate the association between parity and ovarian reserve in reproductive age women. MATERIALS AND METHODS: This cross-sectional study was conducted on 186 women aged 20-35 years. The participants were divided into two main groups. Group A (n=93) included women with at least one parity (pregnancy after 28 weeks), while group B (n=93) included women with no history of pregnancy. We evaluated the following factors related to ovarian reserve: follicle-stimulating hormone (FSH), ovarian antral follicles, anti-Müllerian hormone (AMH), and ovarian volume...
November 9, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27864899/n-glycosylation-at-asn-402-stabilizes-n-cadherin-and-promotes-cell-cell-adhesion-of-glioma-cells
#19
Yaolin Xu, Ruiqi Chang, Fulin Xu, Yan Gao, Fuming Yang, Can Wang, Jin Xiao, Zuopeng Su, Yongyan Bi, Liying Wang, Xiliang Zha
Cadherin is crucial for cell-cell adhesion and N-glycosylation of N-cadherin has been implicated in the process of mammary, renal, and ovarian carcinogenesis. However, whether N-glycosylation of N-cadherin plays a role in glioma remains unknown. Previous studies had indicated that N-glycosylation could occur at three asparagine residues of N-cadherin. By generating and over-expressing N-glycosylation-deficient N-cadherin mutants in the human glioma cell lines SHG66 and U87, we found that mutation of N402 but not of the other potentially N-glycosylated residues destabilized N-cadherin and led to its ubiquitylation and subsequent proteasomal degradation...
November 19, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27862569/fibroblast-growth-factor-10-markedly-improves-in-vitro-maturation-of-porcine-cumulus-oocyte-complexes
#20
Yeo-Jin Son, Seung-Eun Lee, Hyuk Hyun, Min-Young Shin, Yun-Gwi Park, Sang-Gi Jeong, Eun-Young Kim, Se-Pill Park
Growth factors synthesized by ovarian somatic cells affect cumulus cell expansion and oocyte maturation in vitro. Fibroblast growth factor 10 (FGF10), for example, is a known regulator of mammalian cumulus-oocyte complex maturation. In this study, we investigated the effects of 0, 5, 10, 50, and 100 ng/mL FGF10 (5F, 10F, 50F, and 100F, respectively) on in vitro cumulus cell expansion, oocyte maturation, and embryo development. The percentage of fully expanded cumulus cells at the oocyte's metaphase-II (MII) stage was significantly higher in the 10F-treated group than in the control...
November 11, 2016: Molecular Reproduction and Development
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