keyword
MENU ▼
Read by QxMD icon Read
search

Drug geriatrics

keyword
https://www.readbyqxmd.com/read/29790000/o-glcnac-cycling-in-the-developing-adult-and-geriatric-brain
#1
REVIEW
Olof Lagerlöf
Hundreds of proteins in the nervous system are modified by the monosaccharide O-GlcNAc. A single protein is often O-GlcNAcylated on several amino acids and the modification of a single site can play a crucial role for the function of the protein. Despite its complexity, only two enzymes add and remove O-GlcNAc from proteins, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Global and local regulation of these enzymes make it possible for O-GlcNAc to coordinate multiple cellular functions at the same time as regulating specific pathways independently from each other...
May 22, 2018: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29786658/melatonin-as-a-therapy-for-traumatic-brain-injury-a-review-of-published-evidence
#2
REVIEW
Nicole Osier, Emily McGreevy, Lan Pham, Ava Puccio, Dianxu Ren, Yvette P Conley, Sheila Alexander, C Edward Dixon
Melatonin (MEL) is a hormone that is produced in the brain and is known to bind to MEL-specific receptors on neuronal membranes in several brain regions. MEL's documented neuroprotective properties, low toxicity, and ability to cross the blood-brain-barrier have led to its evaluation for patients with traumatic brain injury (TBI), a condition for which there are currently no Food and Drug Administration (FDA)-approved therapies. The purpose of this manuscript is to summarize the evidence surrounding the use of melatonin after TBI, as well as identify existing gaps and future directions...
May 22, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29780096/-the-status-of-glycemic-control-and-hypoglycemia-in-elderly-patients-visiting-the-outpatient-department-specializing-in-diabetes
#3
Yui Soma, Rie Oka, Sumie Fujii, Naoko Ito, Mitsuhiro Kometani, Shigehiro Karashima, Yoshiyu Takeda, Takashi Yoneda, Akimichi Asano
AIM: The Japan Diabetes Society (JDS)/Japan Geriatrics Society (JGS) Joint Committee reported 'Glycemic Targets for Elderly Patients with Diabetes' in 2016. Based on this recommendation, we aimed to clarify 1) the achievement status of glycemic targets in the elderly and 2) the presence of hypoglycemia in real life among elderly individuals with an HbA1c below the lower limit. SUBJECTS AND METHODS: [Analysis I] In 326 elderly with diabetes ≥65 years of age visiting the outpatient department specializing in diabetes, the proportions of patients with HbA1c values below the lower limit and the use of drugs potentially associated with severe hypoglycemia (e...
2018: Nihon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics
https://www.readbyqxmd.com/read/29779417/constipation-in-the-elderly-from-northern-sardinia-is-positively-associated-with-depression-malnutrition-and-female-gender
#4
Maria Pina Dore, Giovanni Mario Pes, Stefano Bibbò, Patrizia Tedde, Gabrio Bassotti
OBJECTIVES: Constipation is a common complaint in older adults. The rise in life expectancy may amplify the problem and increase social expenditure. We investigated the major risk factors associated with constipation in a large sample of elderly. METHODS: Outpatients from Northern Sardinia attending a Geriatric Unit between 2001 and 2014 were enrolled. Demographic and anthropometric data, income, education and self-reported bowel function were collected. The presence of constipation was adjusted for cognitive status, assessed by the Mini-Mental State Examination (MMSE) test; single and cumulative illness rating scale (CIRS); current or past symptomatic depression and anxiety measured by the Geriatric Depression Scale (GDS); nutritional status, evaluated using the Mini-Nutritional Assessment (MNA); type and number of different medications used...
May 20, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29776316/a-systematic-review-and-combined-analysis-of-therapeutic-drug-monitoring-studies-for-oral-paliperidone
#5
Georgios Schoretsanitis, Edoardo Spina, Christoph Hiemke, Jose de Leon
This article includes a combined analysis of therapeutic drug monitoring (TDM) studies and a review of the marketer's data on pharmacological mechanisms. Areas covered: An article search led to the inclusion of 21 paliperidone studies in the systematic review plus 2 case reports. Paliperidone clearance was calculated from: 1) steady-state studies using concentration/dose (C/D) ratios, and 2) single-dose studies describing 24-hour area under the curve calculations. The marketed extended-release formulation has 28% bioavailability...
May 18, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29770467/anticholinergic-load-negatively-correlates-with-recovery-of-cognitive-activities-of-daily-living-for-geriatric-patients-after-stroke-in-the-convalescent-stage
#6
E Kose, T Hirai, T Seki, S Hidaka, T Hamamoto
WHAT IS KNOWN AND OBJECTIVE: Anticholinergic drugs are associated with risks of falls, confusion and cognitive dysfunction. However, the effect of anticholinergic drug use on rehabilitation outcomes after a stroke is poorly documented. We therefore aimed to establish whether the anticholinergic load was associated with functional recovery among geriatric patients convalescing after stroke. METHOD: Consecutive geriatric stroke patients admitted and discharged from a convalescence rehabilitation ward between 2010 and 2016 were included in this retrospective cohort study...
May 16, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29767640/burden-of-exposure-to-potential-interactions-between-antiretroviral-and-non-antiretroviral-medications-in-a-population-of-hiv-positive-patients-aged-50-years-or-older
#7
Alice Ranzani, Letizia Oreni, Massimiliano Agrò, Lorena van den Bogaart, Laura Milazzo, Andrea Giacomelli, Dario Cattaneo, Cristina Gervasoni, Anna Lisa Ridolfo
BACKGROUND: As HIV-infected patients aged 50 years or older are at increased risk of comorbidities and multidrug treatments, we examined their exposure to the potential drug-drug interactions (PDDIs) of antiretroviral (ARV) and other medications. METHODS: This cross-sectional study involved the patients aged 50 years or older receiving ARV and non-ARV medications at our clinic. PDDIs were identified using the University of Liverpool HIV Drug Interaction Checker...
June 1, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29761517/pharmacokinetics-of-intravenous-gentamicin-in-healthy-young-adult-compared-to-aged-alpacas
#8
A Gestrich, D Bedenice, M Ceresia, I Zaghloul
The study objective was to evaluate the effects of age on aminoglycoside pharmacokinetics in eight young-adult (<4 years) and eight aged (≥14 years) healthy alpacas, receiving a single 6.6 mg/kg intravenous gentamicin injection. Heparinized plasma samples were obtained at designated time points following drug administration and frozen at -80°C until assayed by a validated immunoassay (QMS® ). Compartmental and noncompartmental analyses of gentamicin plasma concentrations versus time were performed using WinNonlin (v6...
May 14, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29760940/analyses-of-non-benzodiazepine-induced-adverse-events-and-prognosis-in-elderly-patients-based-on-the-japanese-adverse-drug-event-report-database
#9
Yoshihiro Noguchi, Anri Ueno, Hayato Katsuno, Manami Otsubo, Aki Yoshida, Yuta Kanematsu, Ikuto Sugita, Tomoya Tachi, Teruo Tsuchiya, Hitomi Teramachi
Background: The contents of the guidelines for the use of non-benzodiazepines (Z-drugs) differ slightly between THE JAPANESE SOCIETY OF SLEEP RESEARCH and THE JAPAN GERIATRIC SOCIETY, and the recommended directions are conflicting. Therefore, we analyzed the use of the Japanese Adverse Drug Event Report database (JADER) for identifying adverse events (AEs) caused by Z-drugs and clarifying their occurrence trend and prognosis. Methods: The signal value for comparison was calculated by using the proportional reporting ratio (PRR) and chi-squared test (χ2 ) results of data of elderly and non-elderly patients...
2018: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29745441/appropriateness-of-oral-anticoagulant-therapy-prescription-and-its-associated-factors-in-hospitalized-older-people-with-atrial-fibrillation
#10
Carlotta Franchi, Stefania Antoniazzi, Marco Proietti, Alessandro Nobili, Pier Mannuccio Mannucci
BACKGROUND: Oral anticoagulants (OACs) are effective in preventing stroke in older people with atrial fibrillation (AF). Despite this, they are often underused in this at particularly high risk population. OBJECTIVES: To assess the appropriateness of OAC prescription and its associated factors in hospitalized patients aged 65 years or older. METHODS: Data were obtained from the retrospective phase of SIM-AF study, held in 32 Italian internal medicine and geriatric wards...
May 10, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29739428/incidence-and-outcomes-of-acute-kidney-injury-in-octogenarians-in-jordan
#11
Ashraf O Oweis, Sameeha A Alshelleh
OBJECTIVE: Improvements in the health care system, resulted in a greater number of geriatric patients diagnosed with acute kidney injury (AKI). We evaluated the incidence and outcome of AKI in octogenarians, as studies in the Middle-East region are few; moreover, treatment approaches, in addition to medical decisions, may require special consideration for advanced age to improve the outcomes. RESULTS: At King Abdullah II teaching and referral hospital, we recruited patients aged 80-90 years who were admitted to the medical floor between January 2010 and December 2013...
May 8, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29737457/a-physiologically-based-pharmacokinetic-model-to-describe-ciprofloxacin-pharmacokinetics-over-the-entire-span-of-life
#12
Jan-Frederik Schlender, Donato Teutonico, Katrin Coboeken, Katrin Schnizler, Thomas Eissing, Stefan Willmann, Ulrich Jaehde, Heino Stass
BACKGROUND: Physiologically-based pharmacokinetic (PBPK) modeling has received growing interest as a useful tool for the assessment of drug pharmacokinetics by continuous knowledge integration. OBJECTIVE: The objective of this study was to build a ciprofloxacin PBPK model for intravenous and oral dosing based on a comprehensive literature review, and evaluate the predictive performance towards pediatric and geriatric patients. METHODS: The aim of this report was to establish confidence in simulations of the ciprofloxacin PBPK model along the development process to facilitate reliable predictions outside of the tested adult age range towards the extremes of ages...
May 8, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29731614/comprehensive-geriatric-assessment-prediction-of-postoperative-complications-in-gastrointestinal-cancer-patients-a-meta-analysis
#13
REVIEW
Dan-Dan Xue, Yun Cheng, Mei Wu, Yan Zhang
Background: Gastrointestinal cancer is an age-associated disease, and geriatric patients are mostly likely to suffer from postoperative complications. Some studies indicated that comprehensive geriatric assessment (CGA) could predict postoperative complications in gastrointestinal cancer patients. However, the evidence is mixed. Objective: This study aimed to conduct a meta-analysis to identify the effectiveness of CGA for predicting postoperative complications in gastrointestinal cancer patients...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29725752/-list-based-concepts-in-pharmacotherapy-of-older-and-geriatric-patients
#14
REVIEW
Ulrich Thiem
Pharmacotherapy for older and geriatric patients is a challenge, especially because older and geriatric patients are particularly prone to adverse drug reactions and the evidence for drug use is limited for this patient group; therefore, several list-based recommendations have recently been developed in order to improve appropriate pharmacotherapy. These lists of recommendations differ in their criteria and the compilation of drugs, for example in terms of potentially inappropriate medication, drugs increasing the risk of falling and anticholinergic effects...
May 3, 2018: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29719357/a-study-of-the-clinical-effect-and-dropout-rate-of-drugs-combined-with-group-integrated-psychotherapy-on-elderly-patients-with-depression
#15
Bo Liu, Youguo Tan, Duanfang Cai, Yudiao Liang, Ruini He, Chengwen Liu, Yong Zhou, Cuihua Teng
Background: Relevant studies have shown that group cognitive behavioral therapy is effective in treating patients with depressive disorder, but the dropout rate is high. The present study is aimed to explore the patterns of integrated group psychotherapy. Aims: This study investigated the clinical effects of integrated group psychotherapy for elderly patients with senile depression. Methods: One hundred elderly patients with senile depression were divided into the experiment group (n=50) and the control group (n=50) randomly...
February 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29714994/issues-in-geriatric-care-alzheimer-disease
#16
Kathy Kemle, Richard J Ackermann
Alzheimer disease (AD) occurs in 8.8% of older US adults and is the sixth leading cause of death among older adults. Medicare annual wellness visits require screening for cognitive impairment but do not specify screening methods. Numerous screening instruments are available. If results are positive, evaluation with well-validated assessment tools is needed. If cognitive impairment is confirmed, laboratory tests and imaging studies should be obtained to rule out reversible etiologies. If patients meet diagnostic criteria for AD, clinicians should educate patients and families on the expected course and help them complete advance directives...
May 2018: FP Essentials
https://www.readbyqxmd.com/read/29714993/issues-in-geriatric-care-falls
#17
Dipesh Patel, Richard J Ackermann
One in three older adults falls each year. There are approximately 2.5 million falls among older adults treated in emergency departments. Falls account for 87% of all fractures in this age group. The biggest risk factor for falling is a history of falls. Other risk factors include frailty, sedative and anticholinergic drugs, polypharmacy, and a variety of medical conditions. Current recommendations are that all patients age 65 years and older should be asked about falls each year. Patients also can be screened for fall risk with a variety of approaches including questionnaires and the Timed Up & Go test...
May 2018: FP Essentials
https://www.readbyqxmd.com/read/29708056/development-of-clinical-pharmacy-in-belgian-hospitals-through-pilot-projects-funded-by-the-government
#18
A Somers, A Spinewine, I Spriet, S Steurbaut, P Tulkens, J D Hecq, L Willems, H Robays, M Dhoore, H Yaras, I Vanden Bremt, M Haelterman
Objectives The goal is to develop clinical pharmacy in the Belgian hospitals to improve drug efficacy and to reduce drug-related problems. Methods From 2007 to 2014, financial support was provided by the Belgian federal government for the development of clinical pharmacy in Belgian hospitals. This project was guided by a national Advisory Working Group. Each funded hospital was obliged to describe yearly its clinical pharmacy activities. Results In 2007, 20 pharmacists were funded in 28 pilot hospitals; this number was doubled in 2009 to 40 pharmacists over 54 institutions, representing more than half of all acute Belgian hospitals...
April 30, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29691687/-characteristics-of-pharmacotherapy-in-older-patients-with-rheumatism
#19
REVIEW
H-J Lakomek, Christian Schulz
Due to medical advances and the availability of efficient immunosuppressive therapies, the life-expectancy of people suffering from inflammatory rheumatic diseases is continuously increasing. In Germany, geriatric patients (definition: age older than 70 years combined with geriatric multimorbidity) affected, e. g. by rheumatoid arthritis (RA) frequently receive corticosteroids and less often biologic disease-modifying antirheumatic drugs (bDMARDs) and conventional DMARDs (cDMARDs), which is justified by additionally existing comorbidities and polypharmacy...
April 24, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29687782/status-report-of-analgesic-prescriptions-by-general-practitioners-in-elderly-people-aged-75-and-over-upon-admission-in-geriatric-medicine
#20
Hélène Chevé, Anne-Claire Marinthe, Véronique Lelong-Boulouard, Pascale Lescure, Cyril Guillaumé
The main objective of this study is to describe the current therapeutic strategy for pain in elderly patients, by general practitioners. In this prospective study, 149 patients aged 75 years and over, hospitalized in geriatric medicine at the University Hospital of Caen, were recruited between June and September 2015. All analgesic data was recorded from the patients' prescriptions and medical files. 66% of the patients had at least one analgesic. More than 96% of patients who took analgesics were treated with a step 1 analgesic (mainly paracetamol), and approximately 30% received a step 2 analgesic (69% tramadol)...
April 24, 2018: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
keyword
keyword
26548
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"