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https://www.readbyqxmd.com/read/29029375/treatment-and-disease-management-of-multiple-sclerosis-patients-a-review-for-nurse-practitioners
#1
Cortnee Roman, Kara Menning
BACKGROUND AND PURPOSE: This review discusses the role of the nurse practitioner (NP) in evaluating the clinical effects, potential side effects, and monitoring requirements for treatment options in multiple sclerosis (MS) and provides guidance on how to help patients understand these issues. METHODS: A literature search was conducted on PubMed to identify publications on monitoring and disease management of MS patients. Additional resources included drug information web sites and package inserts...
October 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29028117/comparison-of-weight-based-dosing-strategies-for-intravenous-immunoglobulin-in-patients-with-hematologic-malignancies
#2
Sarah E Stump, Allison J Schepers, Alexis R Jones, Maurice D Alexander, Jessica J Auten
STUDY OBJECTIVE: Intravenous immunoglobulin (IVIG) is a weight-based therapy used to treat and prevent infections in patients with hematologic malignancies. Traditionally, IVIG doses have been calculated using actual body weight (ABW). However, limited pharmacokinetic (PK) data suggest dosing strategies using ideal body weight (IBW) or adjusted body weight (adjBW) may be appropriate given the small volume of distribution of IVIG. The objective of this study was to compare the effectiveness of using a precision-dosing strategy (IBW or adjBW) to a traditional-dosing strategy (ABW) for IVIG in patients with hematologic malignancies or those undergoing hematopoietic stem cell transplant, as well as to perform an IVIG drug use analysis...
October 13, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29027388/causes-of-hiv-drug-non-adherence-in-korea-korea-hiv-aids-cohort-study-2006-2015
#3
Min Jung Kim, Sang Ah Lee, Hyun Ha Chang, Min Ja Kim, Jun Hee Woo, Sang Il Kim, Chun Kang, Mee Kyung Kee, Ju Yeon Choi, Yunsu Choi, Bo Youl Choi, June Myung Kim, Jun Yong Choi, Hyo Youl Kim, Joon Young Song, Shin Woo Kim
We aimed to determine the initial adherence of HIV cohort patients to ART (antiretroviral therapy), and reasons for non-adherence. Patients who received ART at the time of enrollment in the Korea HIV/AIDS Cohort were included in this study. Treatment adherence was determined at the baseline interview by self-reported questionnaire. Eight-hundred thirty two HIV-infected patients received ART. Of these, 253 (30.4%) patients skipped ART more than once a month. The most common reason of skipping medication was "simply forgot" (60...
September 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29026602/re-phrasing-the-question-a-simple-tool-for-evaluation-of-adherence-to-therapy-in-patients-with-inflammatory-bowel-disease
#4
T Engel, B Ungar, G Ben-Haim, N Levhar, R Eliakim, S Ben-Horin
BACKGROUND: Non-adherence to medication in patients with inflammatory bowel disease (IBD) is a challenging problem which is often overlooked or under-estimated by the physician or denied by the patient. We aimed to examine if re-phrasing the wording of the question used by the physician could help in revealing more patients who are non-adherent, and for whom appropriate counseling may be instituted. METHODS: A cross-sectional questionnaire-based study of IBD patients treated in a tertiary center was conducted...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29026306/enhanced-antifungal-activity-of-voriconazole-loaded-nanostructured-lipid-carriers-against-candida-albicans-with-a-dimorphic-switching-model
#5
Baocheng Tian, Qi Yan, Juan Wang, Chen Ding, Sixiang Sai
Candida commonly adheres to implanted medical devices and forms biofilms. Due to the minimal activity of current antifungals against biofilms, new drugs or drug-delivery systems to treat these persistent infections are urgently needed. In the present investigation, voriconazole-loaded nanostructured lipid carriers (Vrc-NLCs) were formulated for enhanced drug-delivery efficiency to C. albicans to increase the antifungal activity of Vrc and to improve the treatment of infectious Candida diseases. Vrc-NLCs were prepared by a hot-melt, high-pressure homogenization method, and size distribution, ζ-potential, morphology, drug-encapsulation efficiency, drug loading, and physical stability were characterized...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29026191/mechanisms-involved-in-the-triggering-of-neutrophil-extracellular-traps-nets-by-candida-glabrata-during-planktonic-and-biofilm-growth
#6
Chad J Johnson, John F Kernien, Amanda R Hoyer, Jeniel E Nett
Candida spp. adhere to medical devices, such as catheters, forming drug-tolerant biofilms that resist killing by the immune system. Little is known about how C. glabrata, an emerging pathogen, resists attack by phagocytes. Here we show that upon encounter with planktonic (non-biofilm) C. glabrata, human neutrophils initially phagocytose the yeast and subsequently release neutrophil extracellular traps (NETs), complexes of DNA, histones, and proteins capable of inhibiting fungal growth and dissemination. When exposed to C...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29024920/chitosan-hydroxyapatite-ha-hydroxypropylmethyl-cellulose-hpmc-spongy-scaffolds-synthesis-and-evaluation-as-potential-alveolar-bone-substitutes
#7
Haffsah Iqbal, Moazzam Ali, Rabia Zeeshan, Zeeshan Mutahir, Farasat Iqbal, Muhammad Azhar Hayat Nawaz, Lubna Shahzadi, Aqif Anwar Chaudhry, Muhammad Yar, Shifang Luan, Ather Farooq Khan, Ihtesham-Ur Rehman
Alveolar bone loss is associated with infections and its augmentation is a pre-requisite for the success of dental implants. In present study, we aim to develop and evaluate novel freeze dried doxycycline loaded chitosan (CS)/hydroxyapatite (HA) spongy scaffolds where hydroxypropylmethyl cellulose (HPMC) was added as a crosslinker. Scaffolds displayed compressive strength of 14MPa/cm(3) and 0.34 as elastic response. The interconnected pore diameter was 41-273μm, favorably provided the template supporting cells and transport...
October 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29024560/enhanced-stem-cell-differentiation-and-immunopurification-of-genome-engineered-human-retinal-ganglion-cells
#8
Valentin M Sluch, Xitiz Chamling, Melissa M Liu, Cynthia A Berlinicke, Jie Cheng, Katherine L Mitchell, Derek S Welsbie, Donald J Zack
Human pluripotent stem cells have the potential to promote biological studies and accelerate drug discovery efforts by making possible direct experimentation on a variety of human cell types of interest. However, stem cell cultures are generally heterogeneous and efficient differentiation and purification protocols are often lacking. Here, we describe the generation of clustered regularly-interspaced short palindromic repeats(CRISPR)-Cas9 engineered reporter knock-in embryonic stem cell lines in which tdTomato and a unique cell-surface protein, THY1...
October 10, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29024009/is-kidney-transplantation-safe-after-careful-selection-of-the-recipients-with-a-history-of-psychotic-disorder
#9
Miklos Z Molnar
The prevalence of both bipolar disorder and schizophrenia is around 1-4% in the general population and represents a relative contraindication for kidney transplantation. There are several reasons for this, including concerns in relation to relapse of psychiatric illness, medication and other post-transplant treatment non-adherence, inadequate social support, emotional and cognitive capability, and potential drug interactions between psychotropic and immunosuppressant medications. Only a small proportion of recipients with psychotic disorder has eventually been transplanted...
October 11, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29022745/real-world-adherence-to-oral-anticoagulant-in-non-valvular-atrial-fibrillation-patients-in-china
#10
Xiao Xiang, Yaying Cao, Kexin Sun, Jing Song, Yaohua Tian, Qiongzhou Yin, Juan Juan, Yonghua Hu
BACKGROUND AND OBJECTIVE: Adherence to oral anticoagulants is crucial for the prevention of ischemic stroke in atrial fibrillation patients; however, evidence of oral-anticoagulant adherence from developing countries is still lacking. Our study aimed to evaluate the current situation and predictors of oral-anticoagulant adherence in non-valvular atrial fibrillation (NVAF) patients in China. METHODS: Records of NVAF patients were obtained from a regional claims database...
October 12, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29022692/paper-spray-ionization-coupled-to-high-resolution-tandem-mass-spectrometry-for-comprehensive-urine-drug-testing-in-comparison-to-liquid-chromatography-coupled-techniques-after-urine-precipitation-or-dried-urine-spot-workup
#11
Julian A Michely, Markus R Meyer, Hans H Maurer
Screening procedures using high resolution (HR)-mass spectrometry (MS) are getting more and more important e.g. for drug testing or adherence monitoring. Approaches usually include time-consuming sample preparation and compound separation by liquid chromatography (LC). The paper spray ionization (PSI) technique coupled to MS might overcome these steps by direct analysis of complex mixtures without extraction and separation. In recent years, this technology proved its potential for quantification and/or qualitative screening in biofluids...
October 12, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29022534/therapeutic-drug-monitoring-of-amlodipine-and-the-z-fhl-hhl-ratio-adherence-tools-in-patients-referred-for-apparent-treatment-resistant-hypertension
#12
E S W Jones, M Lesosky, M Blockman, S Castel, E H Decloedt, S L U Schwager, E D Sturrock, L Wiesner, B L Rayner
BACKGROUND: Non-adherence to antihypertensives is a cause of 'pseudo-treatment-resistant' hypertension. OBJECTIVE: To determine whether monitoring plasma amlodipine concentrations and inhibition of angiotensin-converting enzyme (ACE) can be adjunct adherence tools. METHODS: Patients with hypertension who were prescribed enalapril and amlodipine were enrolled. Blood pressures (BPs) were monitored and an adherence questionnaire was completed...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29022166/patient-views-about-polypharmacy-medication-review-clinics-run-by-clinical-pharmacists-in-gp-practices
#13
Rosie Snell, Tim Langran, Parastou Donyai
Background Polypharmacy can decrease medication adherence and increase the incidence of adverse drug reactions and drug-drug interactions, resulting in falls, hospitalisations and other complications especially in the elderly. Medication-related problems of polypharmacy can be prevented through patient-centred medication reviews but research in this area has been completed largely without examining patients' viewpoints. Objective The aim was to investigate patient views about a clinical pharmacist-led patient-centred polypharmacy medication review service completed within 17 English GP practices with those ≥ 75 years of age and prescribed ≥ 15 medications, during 415 consultations...
October 11, 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29021959/constrictive-pericarditis-caused-by-cutibacterium-propionibacterium-acnes-a-case-report-and-review-of-literature
#14
Troels Bek Jensen, Makhmud Abu El Kheyr, Rajesh Mohey
Constrictive and effusive-constrictive pericarditis are rare cardiac disorders. Only rarely are the conditions caused by purulent infection, and even more infrequently by anaerobe bacteria. We describe a case of constrictive - and effusive-constrictive pericarditis due to Cutibacterium (formerly Propionibacterium) acnes in a 75-year old, immunocompetent and previously healthy patient without any predisposition. The patient was successfully treated with subtotal pericardiectomy and beta-lactam antibacterials...
2017: IDCases
https://www.readbyqxmd.com/read/29021107/marijuana-use-and-hiv-treatment-outcomes-among-pwh-receiving-care-at-an-urban-hiv-clinic
#15
Sagarika Sinha, Mary E McCaul, Heidi E Hutton, Anne K Monroe, Anika Alvanzo, Catherine Lesko, Bryan Lau, Jeanne Keruly, Richard D Moore, Geetanjali Chander
BACKGROUND: While marijuana use is prevalent among persons with HIV (PWH), few studies have examined the relationship between marijuana use and HIV treatment outcomes independent of alcohol and other drug use. METHODS: We conducted a prospective cohort study to examine the relationships between frequency of marijuana use and antiretroviral therapy (ART) adherence and viral suppression in patients enrolled in the Johns Hopkins HIV Clinical Cohort between September 2013 through November 2015 (N=1377)...
November 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29020194/comparison-of-measures-of-adherence-to-hiv-preexposure-prophylaxis-among-adolescent-and-young-men-who-have-sex-with-men-in-the-united-states
#16
Catherine A Koss, Sybil G Hosek, Peter Bacchetti, Peter L Anderson, Albert Y Liu, Howard Horng, Leslie Z Benet, Karen Kuncze, Alexander Louie, Parya Saberi, Craig M Wilson, Monica Gandhi
Background: Young men who have sex with men (MSM) are disproportionately impacted by HIV. Preexposure prophylaxis (PrEP) could reduce HIV acquisition among youth, but sub-optimal adherence threatens effectiveness. Optimal metrics of PrEP adherence among adolescents have not been defined. Methods: The ATN 110 and 113 studies provided daily oral PrEP with tenofovir (TFV) disoproxil fumarate/emtricitabine over 48 weeks to a diverse population of MSM (15-22 years). Self-reported adherence was assessed and PrEP drug concentrations measured from hair and dried blood spot (DBS) samples; 23% of participants received Wisepill electronic monitoring devices...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29017463/subjective-health-expectations-of-patients-with-age-related-macular-degeneration-treated-with-antivegf-drugs
#17
Márta Péntek, Valentin Brodszky, Zsolt Biró, Zsófia Kölkedi, Árpád Dunai, János Németh, Petra Baji, Fanni Rencz, László Gulácsi, Miklós D Resch
BACKGROUND: Subjective expectations regarding future health may influence patients' judgement of current health and treatment effects, as well as adherence to therapies in chronic diseases. We aimed to explore subjective expectations on longevity and future health-related quality of life (HRQOL) of patients with age-related macular degeneration (AMD) treated with antiVEGF injections and analyse the influencing factors. METHODS: Consecutive AMD patients in two ophthalmology centres were included...
October 10, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28994871/evaluation-of-anticoagulation-therapy-in-non-valvular-atrial-fibrillation-in-the-emergency-department
#18
Hanen Ghazali, Jihen Essid, Anware Yahmadi, Moez Mougaida, Mahbouba Chkir, Sami Souissi
INTRODUCTION: The vitamin K antagonists (VKAs) are currently the most effective therapeutic class for the prevention of cerebrovascular eventsin atrial fibrillation (AF) patients. However, several studies showed an under-prescription of this therapy.The aim of the study was to assess the prescription of VKAs in non-valvular AF (NVAF) patients and factors influencing the non-prescription ofsuch treatment. METHODS: We conducted a prospective, observational study in an emergency department (ED)...
November 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28993930/in-search-of-a-standard-when-analyzing-medication-adherence-in-patients-with-heart-failure-using-claims-data-a-systematic-review
#19
REVIEW
Katrin Krueger, Nina Griese-Mammen, Ingrid Schubert, Marita Kieble, Lea Botermann, Ulrich Laufs, Charlotte Kloft, Martin Schulz
To determine and address medication non-adherence is important and may improve patient outcomes. Our aim was to perform a systematic review on the operationalization of adherence measures in patients with heart failure using claims data. We searched the MEDLINE, EMBASE, and Cochrane databases. A quality check of the full-text articles was performed using the Quality in Prognosis Studies tool. We included 28 studies. Eleven studies used the medication possession ratio, 15 the proportion of days covered, and six studies used own methods to calculate medication adherence...
October 9, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28992764/use-of-guidelines-for-reducing-stroke-risk-in-patients-with-nonvalvular-atrial-fibrillation-a-review-from-a-latin-american-perspective
#20
Carlos Cantú-Brito, Gisele Sampaio Silva, Sebastián F Ameriso
Atrial fibrillation (AF) is a prominent risk factor for stroke and a leading cause of death and disability throughout Latin America. Contemporary evidence-based guidelines for the management of AF and stroke incorporate the use of practical and relatively simple scoring methods to estimate both stroke and bleeding risk, in order to assist in matching patients with appropriate interventions. This review examines consistencies and differences among guidelines for reducing stroke risk in patients with AF, assessing the role of user-friendly scoring methods to determine appropriate patients for anticoagulation and other treatment options...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
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