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Drug adherence

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https://www.readbyqxmd.com/read/29691955/pharmacist-led-discharge-medication-counselling-a-scoping-review
#1
REVIEW
Aline F Bonetti, Wálleri C Reis, Natália Fracaro Lombardi, Antonio M Mendes, Harli Pasquini Netto, Inajara Rotta, Fernando Fernandez-Llimos, Roberto Pontarolo
RATIONALE, AIMS, AND OBJECTIVES: Discharge medication counselling has produced improved quality of care and health outcomes, especially by reducing medication errors and readmission rates, and improving medication adherence. However, no studies have assembled an evidence-based discharge counselling process for clinical pharmacists. Thus, the present study aims to map the components of the pharmacist-led discharge medication counselling process. METHODS: We performed a scoping review by searching electronic databases (Pubmed, Scopus, and DOAJ) and conducting a manual search to identify studies published up to July 2017...
April 24, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29689047/nanogp8-is-the-key-regulator-of-stemness-emt-wnt-pathway-chemoresistance-and-other-malignant-phenotypes-in-gastric-cancer-cells
#2
Xia Ma, Bei Wang, Xiaofang Wang, Yujiao Luo, Wufang Fan
BACKGROUND: Accumulating evidence demonstrated that NANOG1, the key transcription factor for embryonic stem cells, is associated with human cancers. NANOGP8, one of the pseudogenes in NANOG gene family, contains an intact open reading frame and also said to be expressed in cancer tissues. Therefore, a systematic study is greatly needed to address the following questions: among NANOG1 and NANOGP8, which gene is the main contributor for NANOG expression in cancer cells and which one is the key regulator responsible for stemness, epithelial-mesenchymal transition (EMT), metastasis, chemoresistance and other malignant phenotypes...
2018: PloS One
https://www.readbyqxmd.com/read/29689040/-potentially-inappropriate-prescriptions-in-elderly-outpatiens-results-of-implicit-criteria-applied-by-clinical-pharmacists
#3
Concetta Di Giorgio, Alessio Provenzani, Piera Polidori
BACKGROUND: Management of therapy in elderly patients is a critical issue in primary care. The physiopathological status is usually complex, and the prescription of multiple drugs is typically required, with a consequent higher risk of adverse effects. Many tools have been developed to cope with this problem, and identify drugs that are inappropriate in the elderly. The objective of the study was to evaluate the appropriateness of therapies in the elderly according to implicit criteria...
April 2018: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/29688947/impact-of-patient-age-and-histological-type-on-radioactive-iodine-avidity-of-recurrent-lesions-of-differentiated-thyroid-carcinoma
#4
Kenichi Nakanishi, Toyone Kikumori, Noriyuki Miyajima, Yuko Takano, Sumiyo Noda, Dai Takeuchi, Shingo Iwano, Yasuhiro Kodera
BACKGROUND: Age is a prognostic factor for recurrent differentiated thyroid carcinoma (DTC) and may be related to radioactive iodine (RAI) nonavidity. Indications for molecular-targeted drugs (MTDs) are currently limited to RAI-refractory DTC. Demonstrating refractoriness to RAI, mainly indicated by RAI nonavidity, may be a barrier to the introduction of MTDs for elderly patients. The present study was conducted to evaluate the impact of age and histological type on the RAI avidity of recurrent lesions of DTC...
April 23, 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29688862/the-cost-effectiveness-of-oral-hiv-pre-exposure-prophylaxis-and-early-antiretroviral-therapy-in-the-presence-of-drug-resistance-among-men-who-have-sex-with-men-in-san-francisco
#5
Mingwang Shen, Yanni Xiao, Libin Rong, Lauren Ancel Meyers, Steven E Bellan
BACKGROUND: Poor adherence to either antiretroviral treatment (ART) or pre-exposure prophylaxis (PrEP) can promote drug resistance, though this risk is thought to be considerably higher for ART. In the population of men who have sex with men (MSM) in San Francisco, PrEP coverage reached 9.6% in 2014 and has continued to rise. Given the risk of drug resistance and high cost of second-line drugs, the costs and benefits of initiating ART earlier while expanding PrEP coverage remain unclear...
April 24, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29688837/use-and-effectiveness-of-peri-operative-cefotetan-versus-cefazolin-plus-metronidazole-for-prevention-of-surgical-site-infection-in-abdominal-surgery-patients
#6
Eleanor Danan, Janessa Smith, Rachel M Kruer, Edina Avdic, Pamela Lipsett, Melanie S Curless, Andrew S Jarrell
BACKGROUND: Current practice guidelines for antimicrobial prophylaxis in surgery recommend a cephamycin or cefazolin plus metronidazole for various abdominal surgeries. In February 2016, cephamycin drug shortages resulted in a change in The Johns Hopkins Hospital's (JHH) recommendation for peri-operative antibiotic prophylaxis in abdominal surgeries from cefotetan to cefazolin plus metronidazole. The primary objective of this study was to quantify the percentage of abdominal surgeries adherent to JHH peri-operative antibiotic prophylaxis guidelines...
April 24, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29688202/-multicentre-observational-study-of-phlebodia-600-in-treatment-of-patients-with-ceap-class-c0-c3-chronic-venous-diseases
#7
Iu M Stoĭko, O B Talibov, M N Iashkin, M N Kudykin, S M Belentsov, O V Katel'nitskaia, I A Suchkov, V Iu Tolstikhin, A É Kletskin, K S Sevost'ianova
The purpose of the study was to evaluate efficacy of Diosmin (Phlebodia 600, Innothera, France) in treatment of patients presenting with class C0s-C3 chronic venous diseases (CVD) according to the CEAP classification. Presented herein are the results of a prospective observational study aimed at assessing the outcomes of two-month administration of Phlebodia 600 (600 mg diosmin) in patients suffering from class C0s-C3 CVD according to the CEAP classification. The study comprised a total of 868 patients, including 175 (20...
2018: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/29686169/risk-factors-for-multidrug-resistant-tuberculosis
#8
Cleopas Martin Rumende
In 2015, 10.4 million people developed tuberculosis (TB) and 580,000 amongst them suffered from multidrug-resistant TB (MDR-TB). From those 580,000 cases of MDR-TB, only 125,000 were detected and reported. A total of 111,000 people began to receive MDR-TB treatment in 2014 while 190,000 MDR-TB patients were estimated to have died, largely due to lack of access to effective treatment. The mechanism of drug resistance can be caused by genetic factors, factors related to previous treatment and other factors such as comorbidity with diabetes mellitus...
January 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29684903/repurposing-itraconazole-to-the-benefit-of-skin-cancer-treatment-a-combined-azole-ddab-nanoencapsulation-strategy
#9
C Carbone, C Martins-Gomes, V Pepe, A M Silva, T Musumeci, G Puglisi, P M Furneri, E B Souto
In this work, we aimed at developing an improved topical SLN formulation combining itraconazole delivery with a coating layer of didodecyldimethylammonium bromide, thus repurposing the drug effectiveness by synergistic skin anticancer effectiveness. In order to obtain a stable SLN formulation with small homogeneously dispersed particles, a deep formulative study was developed screening three different solid lipids (Suppocire NB, Cetyl Palmitate and Dynasan 114) for the SLN preparation by the phase inversion temperature...
April 17, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29684638/medication-related-osteonecrosis-of-the-jaw-a-survey-of-knowledge-attitudes-and-practices-among-dentists-in-the-principality-of-asturias-spain
#10
M Escobedo, L García-Consuegra, S Junquera, S Olay, G Ascani, L Junquera
INTRODUCTION: The objective of this study was to investigate the knowledge and capabilities of dentists and dental students in their last year of study in regard to risk factors of medication-related osteonecrosis of the jaw (MRONJ) in Spain. MATERIAL AND METHOD: We conducted a cross-sectional study consisting of a questionnaire survey in Asturias, Spain. The study was divided into three groups: dentists who worked for the public dental health care system (n=32), dentists who worked exclusively as private health care practitioners (n= 136), and dental students in their last year (year five) of study (n= 38)...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29684622/injectable-drug-depot-engineered-to-release-multiple-ophthalmic-therapeutic-agents-with-precise-time-profiles-for-postoperative-treatment-following-ocular-surgery
#11
Maziar Mohammadi, Kisha Patel, Seyedeh P Alaie, Ron B Shmueli, Cagri G Besirli, Ronald G Larson, Jordan J Green
A multi-drug delivery platform is developed to address current shortcomings of post-operative ocular drug delivery. The sustained biodegradable drug release system is composed of biodegradable polymeric microparticles (MPs) incorporated into a bulk biodegradable hydrogel made from triblock copolymers with poly(ethylene glycol) (PEG) center blocks and hydrophobic biodegradable polyester blocks such as poly(lactide-co-glycolide) (PLGA), Poly(lactic acid) (PLA), or Poly(lactide-co-caprolactone) (PLCL) blocks. This system is engineered to flow as a liquid solution at room temperature for facile injection into the eye and then quickly gel as it warms to physiological body temperatures (approximately 37 °C)...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684534/towards-a-maraviroc-long-acting-injectable-nanoformulation
#12
Lee M Tatham, Alison C Savage, Andrew Dwyer, Marco Siccardi, Trevor Scott, Manoli Vourvahis, Andrew Clark, Steven P Rannard, Andrew Owen
Suboptimal adherence to antiretroviral (ARV) therapy can lead to insufficient drug exposure leading to viral rebound and increased likelihood of resistance. This has driven the development of long-acting injectable (LAI) formulations which may mitigate some of these problems. Maraviroc (MVC) is an orally dosed CCR5 antagonist approved for use in patients infected with CCR5-trophic HIV-1. MVC prevents viral entry into host cells, is readily distributed to biologically relevant tissues and has an alternative resistance profile compared to more commonly used therapies...
April 20, 2018: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/29684387/duodenoscope-reprocessing-practice-patterns-in-u-s-endoscopy-centers-a-survey-study
#13
Adarsh M Thaker, V Raman Muthusamy, Alireza Sedarat, Rabindra R Watson, Michael L Kochman, Andrew S Ross, Stephen Kim
BACKGROUND AND AIMS: After recent outbreaks of duodenoscope-related infections from multidrug-resistant organisms (MDRO), the United States Food and Drug Administration (FDA) recommended implementing one or more of four enhanced reprocessing measures in addition to updated manual cleaning methods and high-level disinfection (HLD). The implementation of these techniques in endoscopy facilities and provider opinions regarding reprocessing priorities remain unknown. METHODS: Physicians, nurse managers, nurses, and infection control staff at endoscopy units performing ERCP in the United States were surveyed to assess current institutional practices and individual opinions regarding future reprocessing solutions...
April 20, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29683993/impact-of-improved-hiv-care-and-treatment-on-prep-effectivenesss-in-the-united-states-2016-2020
#14
Nidhi Khurana, Emine Yaylali, Paul G Farnham, Katherine A Hicks, Benjamin T Allaire, Evin Jacobson, Stephanie L Sansom
BACKGROUND: The effect of improving diagnosis, care, and treatment of persons living with HIV (PLWH) on PrEP effectiveness in the United States has not be well established. METHODS: We used a dynamic, compartmental model that simulates the sexually active US population. We investigated the change in cumulative HIV incidence from 2016 to 2020 for three HIV care continuum levels, and the marginal benefit of PrEP compared with each. We also explored the marginal benefit of PrEP for individual risk groups, and as PrEP adherence, coverage and dropout rates varied...
April 20, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29683856/seroconversion-on-prep-a-case-report-with-segmental-hair-analysis-for-timed-adherence-determination
#15
Joshua T Thaden, Monica Gandhi, Hideaki Okochi, Christopher B Hurt, Mehri S McKellar
OBJECTIVE: We describe the third case report of seroconversion with multidrug resistant (MDR)-HIV despite pre-exposure prophylaxis (PrEP) with emtricitabine (FTC) and tenofovir (TFV) disoproxil (TDF). DESIGN: Case report. METHODS: PrEP adherence was assessed via self-report, pharmacy records, and measuring TFV/FTC levels with liquid-chromatography/tandem-mass-spectrometry in plasma and hair. Segmental hair analysis was performed to assess PrEP adherence over prior months...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683846/medication-non-adherence-multi-tablet-regimens-and-food-insecurity-are-key-experiences-in-the-pathway-to-incomplete-hiv-suppression
#16
Celline C Almeida-Brasil, Erica E M Moodie, Taylor Mclinden, Anne-Marie Hamelin, Sharon L Walmsley, Sean B Rourke, Alexander Wong, Marina B Klein, Joseph Cox
OBJECTIVE: To identify potential pathways by which a variety of factors act to lead to unsuppressed viral load. DESIGN: A prospective cohort of HIV-HCV co-infected adults receiving care from 18 HIV clinics across Canada was followed every 6 months between November 2012 and October 2015. Participants with at least two visits while receiving combined antiretroviral treatment (cART) were included. METHODS: A path analysis was conducted on the basis of ordered sequences of multivariate logistic regressions using generalized estimating equations...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29683841/monotypic-low-level-hiv-viremias-during-art-are-associated-with-disproportionate-production-of-x4-virions-and-systemic-immune-activation
#17
Marta E Bull, Caroline Mitchell, Jaime Soria, Sheila Styrchak, Corey Williams-Wietzikoski, Jillian Legard, Jennifer Mckernan-Mullin, Kelli Kraft, Frankline Onchiri, Joshua Stern, Sarah Holte, Kevin J Ryan, Edward P Acosta, Alberto La Rosa, Robert W Coombs, Eduardo Ticona, Lisa M Frenkel
OBJECTIVE: During effective antiretroviral therapy (ART), low-level plasma viremias (LLV) (HIV RNA >30-1000 copies/ml) can be detected intermittently. We hypothesized that systemic inflammation is associated with LLV either as the cause or result of the production of virions from clonally expanded cells. METHODS: Prospective cohort study of HIV-infected ART-naïve Peruvians enrolled prior to ART and followed for 2 years. Plasma HIV RNA and peripheral blood mononuclear cell (PBMC) HIV DNA concentrations were quantified pre-ART from individuals whose plasma HIV RNA was ART-suppressed...
April 19, 2018: AIDS
https://www.readbyqxmd.com/read/29682627/a-complier-average-causal-effect-analysis-of-the-stimulant-reduction-intervention-using-dosed-exercise-study
#18
Thomas Carmody, Tracy L Greer, Robrina Walker, Chad D Rethorst, Madhukar H Trivedi
Objective: Exercise is a promising treatment for substance use disorders, yet an intention-to-treat analysis of a large, multi-site study found no reduction in stimulant use for exercise versus health education. Exercise adherence was sub-optimal; therefore, secondary post-hoc complier average causal effects (CACE) analysis was conducted to determine the potential effectiveness of adequately dosed exercise. Method: The STimulant use Reduction Intervention using Dosed Exercise study was a randomized controlled trial comparing a 12 kcal/kg/week (KKW) exercise dose versus a health education control conducted at nine residential substance use treatment settings across the U...
June 2018: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29680980/when-a-cure-becomes-the-pathology-mechanical-bowel-obstruction-due-to-herbal-pharmacobezoar-a-case-report-with-review-of-literature
#19
Saurabh Gandhi, Eham Arora, Ajay Bhandarwar, Arun Patil, Amol Wagh, Shubham Gupta
Bezoars are intra-luminal concretions of ingested material which accumulate within the bowel. They are termed pharmacobezoars when the constituent material is drugs. We report a 64-year-old female with abdominal pain and obstipation for 3 days. Patient had completed anti-tuberculous combination therapy for suspected abdominal tuberculosis 25 years ago. She exhibited features of shock with a right iliac fossa lump. Abdominal X-ray displayed multiple air-fluid levels with densely cluttered radio-opacities in the right lower quadrant...
April 21, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29680378/characterisation-of-bergeyella-spp-isolated-from-the-nasal-cavities-of-piglets
#20
M Lorenzo de Arriba, S Lopez-Serrano, N Galofre-Mila, V Aragon
The aim of this study was to characterise bacteria in the genus Bergeyella isolated from the nasal passages of healthy piglets. Nasal swabs from 3 to 4 week-old piglets from eight commercial domestic pig farms and one wild boar farm were cultured under aerobic conditions. Twenty-nine Bergeyella spp. isolates were identified by partial 16S rRNA gene sequencing and 11 genotypes were discriminated by enterobacterial repetitive intergenic consensus (ERIC)-PCR. Bergeyella zoohelcum and Bergeyella porcorum were identified within the 11 genotypes...
April 2018: Veterinary Journal
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