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Wake Forest

Jean-François Brunet, Dominique Dagenais, Marc Therrien, Daniel Gartenberg, Geneviève Forest
Despite its high sensitivity and validity in the context of sleep loss, the Psychomotor Vigilance Test (PVT) could be improved. The aim of the present study was to validate a new smartphone PVT-type application called sleep-2-Peak (s2P) by determining its ability to assess fatigue-related changes in alertness in a context of extended wakefulness. Short 3-min versions of s2P and of the classic PVT were administered at every even hour during a 35-h total sleep deprivation protocol. In addition, subjective measures of sleepiness were collected...
September 8, 2016: Behavior Research Methods
Shanshan Zhu, Yanqian Ding, Zhaoyan Yap, Yingxiong Qiu
Lindera glauca (Lauraceae) is an economically important East Asian forest tree characterized by a dioecy in China and apomixis in Japan. However, patterns of population genetic diversity and structure of this species remain unknown for this species due to a lack of efficient molecular markers. In this study, we employed Illumina sequencing to analyze the transcriptomes of the female and male flower buds of L. glauca. We retrieved 59,753 and 75,075 unigenes for the female and male buds, respectively. Based on sequence similarity, 44,379 (74...
November 2016: Molecular Biology Reports
Huaidong Chen, Wei Chen, Chenglin Liu, Le Zhang, Jing Su, Xiaobo Zhou
Biomedical big data, as a whole, covers numerous features, while each dataset specifically delineates part of them. "Full feature spectrum" knowledge discovery across heterogeneous data sources remains a major challenge. We developed a method called bootstrapping for unified feature association measurement (BUFAM) for pairwise association analysis, and relational dependency network (RDN) modeling for global module detection on features across breast cancer cohorts. Discovered knowledge was cross-validated using data from Wake Forest Baptist Medical Center's electronic medical records and annotated with BioCarta signaling signatures...
2016: Scientific Reports
Peter E Morris, Michael J Berry, D Clark Files, J Clifton Thompson, Jordan Hauser, Lori Flores, Sanjay Dhar, Elizabeth Chmelo, James Lovato, L Douglas Case, Rita N Bakhru, Aarti Sarwal, Selina M Parry, Pamela Campbell, Arthur Mote, Chris Winkelman, Robert D Hite, Barbara Nicklas, Arjun Chatterjee, Michael P Young
IMPORTANCE: Physical rehabilitation in the intensive care unit (ICU) may improve the outcomes of patients with acute respiratory failure. OBJECTIVE: To compare standardized rehabilitation therapy (SRT) to usual ICU care in acute respiratory failure. DESIGN, SETTING, AND PARTICIPANTS: Single-center, randomized clinical trial at Wake Forest Baptist Medical Center, North Carolina. Adult patients (mean age, 58 years; women, 55%) admitted to the ICU with acute respiratory failure requiring mechanical ventilation were randomized to SRT (n=150) or usual care (n=150) from October 2009 through May 2014 with 6-month follow-up...
June 28, 2016: JAMA: the Journal of the American Medical Association
Zhengrui Miao, S Bruce King
Invited for this month's cover picture is the group of Prof. S. Bruce King at the Department of Chemistry of Wake Forest University. The cover picture shows a prefluorescent phosphine-based probe reacting with nitroxyl (HNO) and S -nitrosothiol (RSNO), nitrogen oxide-derived biological signals. Both species react with the prefluorescent probe, but only the product from the HNO reaction can complete a further chemical ligation pathway that results in fluorescence, indicating the presence of HNO. The product of the probe with RSNO does not complete this ligation and does not generate a fluorescent species...
April 2016: ChemistryOpen
Jessica McNeil, Éric Doucet, Jean-François Brunet, Luzia Jaeger Hintze, Isabelle Chaumont, Émilie Langlois, Riley Maitland, Alexandre Riopel, Geneviève Forest
Experimental evidence suggests that sleep restriction increases energy intake (EI) and may alter energy expenditure (EE). However, it is unknown whether the timing of a sleep restriction period impacts EI and EE the following day. Hence, we examined the effects of sleep restriction with an advanced wake-time or delayed bedtime on next day EI and EE. Twelve men and 6 women (age: 23±4years, body fat: 18.8±10.1%) participated in 3 randomized crossover sessions: control (habitual bed- and wake-times), 50% sleep restriction with an advanced wake-time and 50% sleep restriction with a delayed bedtime...
October 1, 2016: Physiology & Behavior
Jill A Ohar, Barbara P Yawn, Gregg L Ruppel, James F Donohue
BACKGROUND: Chronic lung disease is common and often under-diagnosed. METHODS: To test a simple rule for conducting spirometry we reviewed spirograms from two populations, occupational medicine evaluations (OME) conducted by Saint Louis and Wake Forest Universities at 3 sites (n = 3260, mean age 64.14 years, 95 % CI 58.94-69.34, 97 % men) and conducted by Wake Forest University preop clinic (POC) at one site (n = 845, mean age 62.10 years, 95 % CI 50...
June 4, 2016: BMC Family Practice
Shu-Yang Yu, Hong-Man Wang
The collaboration network of English publications on animal-derived regenerative implantable medical devices based on tissue engineering technology and its evolving processes and current states were mapped in this paper. A total of 10 159 English papers published before 1 January 2015 were obtained in eight databases. Social network analysis was conducted on these papers by utilizing UCINET software and Statistical Analysis Software for Informatics researched and developed by Peking University. The collaboration network has evolved from scattered formation to single-core dominated, and then to a core-edge one; collaboration has become more frequent and wider; network density and centrality have decreased; USA, UK and China are the top three countries with Wake Forest University, Harvard University and Tufts University being the top three contributing institutions cooperated mostly during the period between 2010 and 2014; plenty of edge institutes exist...
September 2016: Regenerative Biomaterials
Christina L Ross, Thaleia Teli, Benjamin S Harrison
Context • During cell-communication processes, endogenous and exogenous signaling affects normal and pathological developmental conditions. Exogenous influences, such as extra-low-frequency (ELF) electromagnetic fields (EMFs) have been shown to affect pain and inflammation by modulating G-protein coupling receptors (GPCRs), downregulating cyclooxygenase-2 (Cox-2) activity, and downregulating inflammatory modulators, such as tumor necrosis factor alpha (TNF-α) and interleukin 1 beta (IL-1β) as well as the transcription factor nuclear factor kappa B (NF-κB)...
March 2016: Alternative Therapies in Health and Medicine
Farah Z Dawood, Andrew Boerkircher, Bryon Rubery, Don Hire, Elsayed Z Soliman
BACKGROUND: Temporary-permanent pacemakers [TPPM] are externally placed permanent generators attached to active fixation transvenous leads. TPPM can be used as an alternative to standard temporary pacing leads when placement of a permanent pacemaker is contraindicated. We sought to determine the incidence and risk factors for early (within 6months) mortality after placement of a TPPM. METHODS: Electronic medical records were used to extract baseline characteristics for 152 patients from Wake Forest Baptist Medical Center who had a TPPM placed between the years 2007 and 2012...
July 2016: Journal of Electrocardiology
Jun Ma, Meijian Guan, Donald W Bowden, Maggie C Y Ng, Pamela J Hicks, Janice P Lea, Lijun Ma, Chuan Gao, Nicholette D Palmer, Barry I Freedman
BACKGROUND AND OBJECTIVES: Genetic variation in the cubilin (CUBN) gene is associated with albuminuria and CKD. Common and rare coding variants in CUBN and the gene encoding its transport partner megalin (LRP2) were assessed for association with ESRD in blacks. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Sixty-six CUBN and LRP2 single-nucleotide polymorphisms (SNPs) were selected and analyzed in this multistage study. Exome sequencing data from 529 blacks with type 2 diabetes (T2D) -associated ESRD and 535 controls lacking T2D or nephropathy (the Type 2 Diabetes Genes [T2D-GENES] Consortium) were first evaluated, focusing on coding variants in CUBN and LRP2; 15 potentially associated SNPs identified from the T2D-GENES Consortium as well as 51 other selected SNPs were then assessed in an independent T2D-ESRD sample set of blacks (the Affymetrix Axiom Biobank Genotyping Array [AXIOM]; 2041 patients with T2D-ESRD, 627 patients with T2D without nephropathy, and 1140 nondiabetic, non-nephropathy controls)...
June 6, 2016: Clinical Journal of the American Society of Nephrology: CJASN
Lijun Ma, Carl D Langefeld, Mary E Comeau, Jason A Bonomo, Michael V Rocco, John M Burkart, Jasmin Divers, Nicholette D Palmer, Pamela J Hicks, Donald W Bowden, Janice P Lea, Jenna O Krisher, Margo J Clay, Barry I Freedman
Relative to European Americans, evidence supports that African Americans with end-stage renal disease (ESRD) survive longer on dialysis. Renal-risk variants in the apolipoprotein L1 gene (APOL1), associated with nondiabetic nephropathy and less subclinical atherosclerosis, may contribute to dialysis outcomes. Here, APOL1 renal-risk variants were assessed for association with dialytic survival in 450 diabetic and 275 nondiabetic African American hemodialysis patients from Wake Forest and Emory School of Medicine outpatient facilities...
August 2016: Kidney International
Liwei Chen, Zhenzhen Zhang, Wen Chen, Paul K Whelton, Lawrence J Appel
OBJECTIVES: To determine the effect of sodium (Na) reduction on occurrence of headaches. METHODS: In the Trial of Nonpharmacologic Interventions in the Elderly, 975 men and woman (aged 60-80 years) with hypertension were randomized to a Na-reduction intervention or control group and were followed for up to 36 months. The study was conducted between 1992 and 1995 at 4 clinical centers (Johns Hopkins University, Wake Forest University School of Medicine, Robert Wood Johnson Medical School, and the University of Tennessee)...
July 2016: American Journal of Public Health
Ellen S Satteson, Michael F Reynolds, Austin M Bond, Ivo A Pestana
Nipple-areola reconstruction represents the completion of the breast restorative process and is associated with significant positive psychological implications. While factors such as medical comorbidities, smoking status, and radiation therapy have been shown to be associated with an increase in complications following breast reconstruction, their impact on nipple reconstruction remains largely unaddressed in the literature. An IRB-approved, retrospective review of 472 patients who underwent nipple reconstruction at Wake Forest University over a 15-year period was completed...
July 2016: Breast Journal
Annegret F Hannawa, Yuki Shigemoto, Todd D Little
RATIONALE: This study investigates the intrapersonal and interpersonal factors and processes that are associated with patient forgiveness of a provider in the aftermath of a harmful medical error. OBJECTIVE: This study aims to examine what antecedents are most predictive of patient forgiveness and non-forgiveness, and the extent to which social-cognitive factors (i.e., fault attributions, empathy, rumination) influence the forgiveness process. Furthermore, the study evaluates the role of different disclosure styles in two different forgiveness models, and measures their respective causal outcomes...
May 2016: Social Science & Medicine
Irina V Koreen, Elysa A McClintic, Ryan T Mott, Constance Stanton, R Patrick Yeatts
PURPOSE: To determine the safety, durability, and bio compatibility of 2.5% polyacrylamide hydrogel (Aquamid, Specialty European Pharma, Ltd., London, UK) as an injectable viscoelastic implant following evisceration in a rabbit model. METHODS: The protocol was reviewed and approved by the Wake Forest Institutional Animal Care and Use Committee. Adult New Zealand rabbits underwent cornea-sparing evisceration of the right eye with injection of 2.5% polyacrylamide hydrogel implant...
March 24, 2016: Ophthalmic Plastic and Reconstructive Surgery
V M Dotson, F C Hsu, T Y Langaee, C W McDonough, A C King, R A Cohen, A B Newman, S B Kritchevsky, V Myers, T M Manini, M Pahor
BACKGROUND: Converging evidence suggests that physical activity is an effective intervention for both clinical depression and sub-threshold depressive symptoms; however, findings are not always consistent. These mixed results might reflect heterogeneity in response to physical activity, with some subgroups of individuals responding positively, but not others. OBJECTIVES: 1) To examine the impact of genetic variation and sex on changes in depressive symptoms in older adults after a physical activity (PA) intervention, and 2) to determine if PA differentially improves particular symptom dimensions of depression...
2016: Journal of Frailty & Aging
Marc-Oliver Adams, Konrad Fiedler
Insect herbivory constitutes an important constraint in the viability and management of targeted reforestation sites. Focusing on young experimental stands at about 2000 m elevation in southern Ecuador, we examined foliar damage over one season as a function of tree species and habitat. Native tree species (Successional hardwood: Cedrela montana and Tabebuia chrysantha; fast-growing pioneer: Heliocarpus americanus) have been planted among prevailing local landcover types (abandoned pasture, secondary shrub vegetation, and a Pinus patula plantation) in 2003/4...
2016: PloS One
Ilya Gorbachinsky, Kyle Wood, Marc Colaco, Sij Hemal, Jayadev Mettu, Majid Mirzazadeh, Dean G Assimos, Jorge Gutierrez-Aćeves
PURPOSE: Renal function following percutaneous nephrolithotomy has long been a concern to urologists, especially in the setting of multi-tract access. We determined whether the risk of renal injury after multi-tract percutaneous nephrolithotomy was greater than after a single access approach. MATERIALS AND METHODS: We retrospectively reviewed the records of 307 consecutive patients treated with percutaneous nephrolithotomy from 2011 to 2012 at Wake Forest Health...
July 2016: Journal of Urology
James R Beardsley, Catherine M Jones, John Williamson, Jason Chou, Margaret Currie-Coyoy, Teresa Jackson
PURPOSE: Pharmacy department contributions to a medical center's broad initiative to improve sepsis care outcomes are described. SUMMARY: Timely and appropriate antimicrobial therapy is a key factor in optimizing treatment outcomes in patients with severe sepsis or septic shock. The inpatient pharmacy at Wake Forest Baptist Health implemented standardized processes to reduce order turnaround time and facilitate prompt antibiotic administration as part of the hospital's multidisciplinary "Code Sepsis" initiative...
February 1, 2016: American Journal of Health-system Pharmacy: AJHP
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