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https://www.readbyqxmd.com/read/28918569/highlights-from-the-ninth-international-symposium-of-thrombosis-and-anticoagulation-ista-ix-october-15-2016-salvador-bahia-brazil
#1
REVIEW
Renato D Lopes, Patricia O Guimarães, Elaine Hylek, Gilson S Feitosa-Filho, Luiz Ritt, Nivaldo Filgueiras, Eduardo Darzé, Mario S Rocha, Luis P Magalhães, Antonio Carlos Sobral Sousa, Luis Claudio Correia, Lucas Hollanda Oliveira, David A Garcia
To discuss and share knowledge about advances in the care of patients with thrombotic disorders, the Ninth International Symposium of Thrombosis and Anticoagulation was held in Salvador, Bahia, Brazil, on October 15, 2016. This scientific program was developed by clinicians for clinicians and was promoted by two major clinical research institutes-the Brazilian Clinical Research Institute and the Duke Clinical Research Institute of the Duke University School of Medicine. Comprising academic presentations and open discussion, the symposium had as its primary goal to educate, motivate, and inspire internists, cardiologists, hematologists, and other physicians by convening national and international visionaries, thought-leaders, and dedicated clinician-scientists...
September 16, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/28917497/comparison-of-outcome-of-possible-versus-definite-infective-endocarditis-involving-prosthetic-or-bioprosthetic-heart-valves
#2
Laurent Fauchier, Lauriane Pericart, Thierry Bourguignon, Thibaud Genet, Arnaud Bisson, Anne Bernard, Louis Bernard, Dominique Babuty
The objectives of this study were to describe and compare the clinical characteristics and outcomes of patients with definite and possible infective endocarditis (IE) involving prosthetic heart valve, and to identify prognostic factors for long-term mortality, using data from an unselected cohort of consecutive patients. We studied data from 133 consecutive patients with IE involving prosthetic heart valve seen in an academic institution between 1990 and 2012. Patients were classified according to the modified Duke criteria for IE: patients with possible IE (n = 47, 35%) and patients with definite IE (n = 86, 65%)...
August 7, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28917398/hydrogel-ocular-sealant-for-clear-corneal-incisions-in-cataract-surgery
#3
Nambi Nallasamy, Karen E Grove, Gary L Legault, Melissa B Daluvoy, Terry Kim
PURPOSE: To assess the relationship between use of a hydrogel ocular sealant (Resure) to secure clear corneal incisions (CCIs) in cataract surgery and surgeon efficiency, patient symptomatology, and postoperative results. SETTING: Duke University Eye Center, Durham, North Carolina, USA. DESIGN: Retrospective case series. METHODS: A 1:1 matched cohort of hydrogel sealant exposure-discordant eyes of cataract surgery patients was retrospectively generated...
August 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28916555/first-person-seth-zimmerman
#4
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Seth Zimmerman is the first author on 'Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration', published in Journal of Cell Science. Seth completed the work in this article as a PhD student under the supervision of Jim Bear and Brian Kuhlman at University of North Carolina at Chapel Hill, USA...
September 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28912165/holistic-care-of-complicated-tuberculosis-in-healthcare-settings-with-limited-resources
#5
Trevor Duke, Sharon Kasa Tom, Harry Poka, Henry Welch
In recent years, most of the focus on improving the quality of paediatric care in low-income countries has been on improving primary care using the Integrated Management of Childhood Illness, and improving triage and emergency treatment in hospitals aimed at reducing deaths in the first 24 hours. There has been little attention paid to improving the quality of care for children with chronic or complex diseases. Children with complicated forms of tuberculosis (TB), including central nervous system and chronic pulmonary TB, provide examples of acute and chronic multisystem paediatric illnesses that commonly present to district-level and second-level referral hospitals in low-income countries...
September 14, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28905447/assessment-of-the-quality-of-neonatal-care-in-the-solomon-islands
#6
Shidan Tosif, Titus Nasi, Amy Gray, Nahad Sadr-Azodi, Divi Ogaoga, Trevor Duke
AIM: To identify strengths and obstacles for improving the quality of newborn care in the Solomon Islands. Improving the quality of newborn care is a priority in the Sustainable Development Goals and the Action Plan for Healthy Newborns in the Western Pacific. The neonatal mortality rate in the Solomon Islands, a lower-middle-income country, has improved slower than overall child mortality. In 2013, neonatal mortality (13.2/1000) constituted 44% of under-5 deaths (30.1/1000). METHODS: A cross-sectional study of newborn care in five provincial hospitals using a World Health Organization assessment tool for hospital quality of care...
September 14, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28899259/delivery-of-hiv-antiretroviral-therapy-adherence-support-services-by-hiv-care-providers-in-the-united-states-2013-to-2014
#7
John Weiser, Linda Beer, John T Brooks, Kathleen Irwin, Brady T West, Christopher C Duke, Garrett W Gremel, Jacek Skarbinski
BACKGROUND: Little is known about clinicians' adoption of recommendations of the International Association of Providers of AIDS Care and others for supporting adherence to antiretroviral therapy (ART). METHODS: We surveyed a probability sample of US HIV care providers to estimate the percentage offering 3 ART adherence support services to most or all patients and assessed the characteristics of providers offering all 3 services (comprehensive support) to most or all patients...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
https://www.readbyqxmd.com/read/28892660/phytotoxic-triterpene-saponins-from-bellis-longifolia-an-endemic-plant-of-crete
#8
Maria I Stavropoulou, Apostolis Angelis, Nektarios Aligiannis, Eleftherios Kalpoutzakis, Sofia Mitakou, Stephen O Duke, Nikolas Fokialakis
In a study of 62 plant species of the Cretan flora for their phytotoxic activity, plants were extracted successively with CH2Cl2, MeOH and H2O. Phytotoxicity evaluation of the 240 extracts was performed against Lactuca sativa L. and Agrostis stolonifera L.. The MeOH extract of Bellis longifolia was the most phytotoxic. Bioassay-guided fractionation revealed that a fraction consisting mainly of saponins was the most effective. Separation of the saponins was performed using initially a step-gradient Centrifugal Partition Chromatography (CPC)...
September 7, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28885963/three-year-analysis-of-value-and-utilization-after-development-of-an-ultrasound-based-orthopedic-injection-clinic
#9
Chase Dukes, Thomas Melton, Eric Turner, Andrew Jackson, Jason Grassbaugh, John Slevin, Edward D Arrington, Josef K Eichinger
INTRODUCTION: Sonography is an effective method of diagnosing and treating musculoskeletal conditions, and the use of ultrasound has been shown to improve the accuracy, safety, and efficacy of both therapeutic and diagnostic injections. In 2012, we established an injection clinic at our institution to address our growing need for diagnostic and therapeutic injections. METHODS: We performed an analysis of value and utilization following the development of an orthopedic injection clinic...
September 2017: Military Medicine
https://www.readbyqxmd.com/read/28885857/exaggerated-increase-in-pulmonary-artery-pressure-during-exercise-in-adults-born-preterm
#10
Steven S Laurie, Jonathan E Elliott, Kara M Beasley, Tyler S Mangum, Randall D Goodman, Joseph W Duke, Igor M Gladstone, Andrew T Lovering
No abstract text is available yet for this article.
September 8, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28885318/gamma-prime-%C3%AE-fibrinogen-and-carotid-intima-media-thickness-the-atherosclerosis-risk-in-communities-study
#11
Pamela J Schreiner, Duke Appiah, Aaron R Folsom
: We assessed if γ' fibrinogen, an isoform of fibrinogen, is independently associated with subclinical atherosclerosis beyond total fibrinogen in black and white men and women participating in the Atherosclerosis Risk in Communities study. Fasting γ' fibrinogen was measured in 6847 Atherosclerosis Risk in Communities participants, ages 51-70 years, in 1993-1995. Carotid intima-media far wall thickness (CIMT) was measured by B-mode ultrasonography at the common, internal and bifurcation carotids. The association of γ' fibrinogen tertiles with overall and segment-specific mean CIMT was assessed with linear regression, controlling for fibrinogen as well as cardiovascular risk factors, including high-sensitivity C-reactive protein and D-dimer...
September 6, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/28882113/new-use-of-low-dose-aspirin-and-risk-of-colorectal-cancer-by-stage-at-diagnosis-a-nested-case-control-study-in-uk-general-practice
#12
Luis A García Rodríguez, Montse Soriano-Gabarró, Susan Bromley, Angel Lanas, Lucía Cea Soriano
BACKGROUND: Evidence from clinical trial populations suggests low-dose aspirin reduces the risk of colorectal cancer (CRC). Part of this reduction in risk might be due to protection against metastatic disease. METHODS: We investigated the risk of CRC among new-users of low-dose aspirin (75-300 mg), including risk by stage at diagnosis. Using The Health Improvement Network, we conducted a cohort study with nested case-control analysis. Two cohorts (N = 170,336 each) aged 40-89 years from 2000 to 2009 and free of cancer were identified: i) new-users of low-dose aspirin, ii) non-users of low-dose aspirin, at start of follow-up, matched by age, sex and previous primary care practitioner visits...
September 7, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28882005/cats-coordinates-of-atoms-by-taylor-series-protein-design-with-backbone-flexibility-in-all-locally-feasible-directions
#13
Mark A Hallen, Bruce R Donald
Motivation: When proteins mutate or bind to ligands, their backbones often move significantly, especially in loop regions. Computational protein design algorithms must model these motions in order to accurately optimize protein stability and binding affinity. However, methods for backbone conformational search in design have been much more limited than for sidechain conformational search. This is especially true for combinatorial protein design algorithms, which aim to search a large sequence space efficiently and thus cannot rely on temporal simulation of each candidate sequence...
July 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28876412/psychological-model-of-art-adherence-behaviors-in-persons-living-with-hiv-aids-in-mexico-a-structural-equation-analysis
#14
José Luis Ybarra Sagarduy, Julio Alfonso Piña López, Mónica Teresa González Ramírez, Luis Enrique Fierros Dávila
OBJECTIVE: The objective of this study has been to test the ability of variables of a psychological model to predict antiretroviral therapy medication adherence behavior. METHODS: We have conducted a cross-sectional study among 172 persons living with HIV/AIDS (PLWHA), who completed four self-administered assessments: 1) the Psychological Variables and Adherence Behaviors Questionnaire, 2) the Stress-Related Situation Scale to assess the variable of Personality, 3) The Zung Depression Scale, and 4) the Duke-UNC Functional Social Support Questionnaire...
September 4, 2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28872742/association-between-social-support-functional-status-and-change-in-health-related-quality-of-life-and-changes-in-anxiety-and-depression-in-colorectal-cancer-patients
#15
REVIEW
M Gonzalez-Saenz de Tejada, A Bilbao, M Baré, E Briones, C Sarasqueta, J M Quintana, A Escobar
OBJECTIVE: The aim of this study was to explore the association between baseline social support, functional status, and change in health-related quality of life (HRQoL) in colorectal cancer patients and change in anxiety and depression measured by Hospital Anxiety and Depression Scale (HADS) at 1 year after surgery. METHODS: Consecutive patients who were due to undergo therapeutic surgery for the first time for colon or rectal cancer in 9 hospitals in Spain were eligible for the study...
September 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28872144/volume-segmentation-and-analysis-of-biological-materials-using-survos-super-region-volume-segmentation-workbench
#16
Michele C Darrow, Imanol Luengo, Mark Basham, Matthew C Spink, Sarah Irvine, Andrew P French, Alun W Ashton, Elizabeth M H Duke
Segmentation is the process of isolating specific regions or objects within an imaged volume, so that further study can be undertaken on these areas of interest. When considering the analysis of complex biological systems, the segmentation of three-dimensional image data is a time consuming and labor intensive step. With the increased availability of many imaging modalities and with automated data collection schemes, this poses an increased challenge for the modern experimental biologist to move from data to knowledge...
August 23, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28870917/the-association-between-hsp90-topoisomerase-i-immunophenotype-and-the-clinical-features-of-colorectal-cancers-in-respect-to-kras-gene-status
#17
Julia K Bar, Anna Lis-Nawara, Piotr Grelewski, Leszek Noga, Zygmunt Grzebieniak, Michał Jeleń
AIM: The aim of this study was to investigate heat shock protein 90 (HSP90) and topoisomerase I (Topo I) expression and the association between both proteins and clinicopathological parameters of colorectal cancer (CRC), in order to describe their role in tumor biology regarding to Kirsten Ras (KRAS) - positive/negative cases. MATERIALS AND METHODS: Expression of HSP90 and Topo I, and KRAS gene mutations were estimated in primary CRCs. RESULTS: HSP90/Topo I immunophenotype correlated with gender, Duke staging, tumor grade and lymph node metastasis (p<0...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28869451/spalt-like-transcription-factor-4-as-a-potential-diagnostic-and-prognostic-marker-of-colorectal-cancer
#18
Hong-Kun Wu, Chang Liu, Xiao-Xia Fan, Hao Wang, Lin Zhou
OBJECTIVE: The study aimed to investigate the role of spalt-like transcription factor 4 (SALL4) in the diagnosis and prognosis of colorectal cancer (CRC). METHODS: Between May 2008 and January 2010, 135 patients with CRC were recruited and subsequently assigned into the case group of the study. Additionally, 140 healthy individuals under identical conditions were selected as the control group. Venous blood was collected from all subjects. High expression of SALL4 was detected by immunohistochemistry, and SALL4 serum levels were detected using ELISA...
August 23, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28868055/investigation-of-the-influence-of-leaf-thickness-on-canopy-reflectance-and-physiological-traits-in-upland-and-pima-cotton-populations
#19
Duke Pauli, Jeffrey W White, Pedro Andrade-Sanchez, Matthew M Conley, John Heun, Kelly R Thorp, Andrew N French, Douglas J Hunsaker, Elizabete Carmo-Silva, Guangyao Wang, Michael A Gore
Many systems for field-based, high-throughput phenotyping (FB-HTP) quantify and characterize the reflected radiation from the crop canopy to derive phenotypes, as well as infer plant function and health status. However, given the technology's nascent status, it remains unknown how biophysical and physiological properties of the plant canopy impact downstream interpretation and application of canopy reflectance data. In that light, we assessed relationships between leaf thickness and several canopy-associated traits, including normalized difference vegetation index (NDVI), which was collected via active reflectance sensors carried on a mobile FB-HTP system, carbon isotope discrimination (CID), and chlorophyll content...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28867311/distal-technologies-and-type-1-diabetes-management
#20
REVIEW
Danny C Duke, Samantha Barry, David V Wagner, Jane Speight, Pratik Choudhary, Michael A Harris
Type 1 diabetes requires intensive self-management to avoid acute and long-term health complications. In the past two decades, substantial advances in technology have enabled more effective and convenient self-management of type 1 diabetes. Although proximal technologies (eg, insulin pumps, continuous glucose monitors, closed-loop and artificial pancreas systems) have been the subject of frequent systematic and narrative reviews, distal technologies have received scant attention. Distal technologies refer to electronic systems designed to provide a service remotely and include heterogeneous systems such as telehealth, mobile health applications, game-based support, social platforms, and patient portals...
August 31, 2017: Lancet Diabetes & Endocrinology
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