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https://www.readbyqxmd.com/read/29783763/integrated-framework-of-load-monitoring-by-a-combination-of-smartphone-applications-wearables-and-point-of-care-testing-provides-feedback-that-allows-individual-responsive-adjustments-to-activities-of-daily-living
#1
Peter Düking, Silvia Achtzehn, Hans-Christer Holmberg, Billy Sperlich
Athletes schedule their training and recovery in periods, often utilizing a pre-defined strategy. To avoid underperformance and/or compromised health, the external load during training should take into account the individual's physiological and perceptual responses. No single variable provides an adequate basis for planning, but continuous monitoring of a combination of several indicators of internal and external load during training, recovery and off-training as well may allow individual responsive adjustments of a training program in an effective manner...
May 19, 2018: Sensors
https://www.readbyqxmd.com/read/29780001/automated-typing-of-red-blood-cell-and-platelet-antigens-a-whole-genome-sequencing-study
#2
William J Lane, Connie M Westhoff, Nicholas S Gleadall, Maria Aguad, Robin Smeland-Wagman, Sunitha Vege, Daimon P Simmons, Helen H Mah, Matthew S Lebo, Klaudia Walter, Nicole Soranzo, Emanuele Di Angelantonio, John Danesh, David J Roberts, Nick A Watkins, Willem H Ouwehand, Adam S Butterworth, Richard M Kaufman, Heidi L Rehm, Leslie E Silberstein, Robert C Green
BACKGROUND: There are more than 300 known red blood cell (RBC) antigens and 33 platelet antigens that differ between individuals. Sensitisation to antigens is a serious complication that can occur in prenatal medicine and after blood transfusion, particularly for patients who require multiple transfusions. Although pre-transfusion compatibility testing largely relies on serological methods, reagents are not available for many antigens. Methods based on single-nucleotide polymorphism (SNP) arrays have been used, but typing for ABO and Rh-the most important blood groups-cannot be done with SNP typing alone...
May 17, 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29779448/the-duke-the-soldier-of-fortune-and-a-rosicrucian-legacy-exploring-the-roles-of-manuscripts-in-early-modern-alchemy
#3
Mike A Zuber
By the time it was published in 1705, the Speculum Sapientiae claimed to have had a long history going back to 1672. However, the fact that exaggerated stories were commonplace in alchemical literature leads us to question its credibility. This paper explores the secret lives of this alchemical text prior to its print publication to clarify the roles of manuscripts in early-modern alchemy. Specifically, I argue that there were three aspects that could distinguish manuscript from print: provenance, materiality, and exclusivity...
May 19, 2018: Ambix
https://www.readbyqxmd.com/read/29779006/new-who-standards-for-improving-the-quality-of-healthcare-for-children-and-adolescents
#4
EDITORIAL
Trevor Duke
No abstract text is available yet for this article.
May 19, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29770230/the-influence-of-education-and-apolipoprotein-%C3%AE%C2%B5-4-on-mortality-in-community-dwelling-elderly-men-and-women
#5
Duke Appiah, Richard N Baumgartner
We investigated the risk of death in relation to the apolipoprotein ε 4 allele and evaluated how it interacts with education in 504 elderly adults (mean age 73 years, 65.3% women) who were enrolled in 1993 into the New Mexico Aging Process Study. During 9 years of follow-up, apolipoprotein ε 2 appeared to be associated with a lower risk for all-cause mortality (hazard ratio (HR) = 0.73, 95% confidence interval (CI): 0.30-1.71) compared to apolipoprotein ε 3 carriers in models adjusted for age, sociodemographic variables, medical conditions, adiposity, and lifestyle factors...
2018: Journal of Aging Research
https://www.readbyqxmd.com/read/29769371/how-are-we-currently-training-and-maintaining-clinical-readiness-of-us-and-uk-military-surgeons-responsible-for-managing-head-face-and-neck-wounds-on-deployment
#6
John Breeze, J G Combes, J DuBose, D B Powers
INTRODUCTION: The conflicts in Iraq and Afghanistan provided military surgeons from the USA and the UK with extensive experience into the management of injuries to the head, face and neck (HFN) from high energy bullets and explosive weaponry. The challenge is now to maintain the expertise in managing such injuries for future military deployments. METHODS: The manner in which each country approaches four parameters required for a surgeon to competently treat HFN wounds in deployed military environments was compared...
May 16, 2018: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/29764866/lrrc15-is-a-novel-mesenchymal-protein-and-stromal-target-for-antibody-drug-conjugates
#7
James W Purcell, Sonia G Tanlimco, Jonathan A Hickson, Melvin Fox, Mien Sho, Lisa Durkin, Tamar Uziel, Rick Powers, Kelly D Foster-Duke, Thomas McGonigal, Subashri Kumar, Josue Samayoa, Dong Zhang, Joann P Palma, Sasmita Mishra, Diane Hollenbaugh, Kurt Gish, Susan E Morgan-Lappe, Eric D Hsi, Debra T Chao
Progress in understanding tumor stromal biology has been constrained in part because cancer-associated fibroblasts (CAF) are a heterogeneous population with limited cell type-specific protein markers. Using RNA expression profiling, we identified the membrane protein leucine rich repeat containing 15 (LRRC15) as highly expressed in multiple solid tumor indications with limited normal tissue expression. LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e...
May 15, 2018: Cancer Research
https://www.readbyqxmd.com/read/29764833/early-prosthetic-valve-endocarditis-after-transcatheter-aortic-valve-implantation-using-st-jude-medical-portico-valve
#8
Abdalla Ibrahim, Aneeq Ahmed, Thomas Kiernan, Samer Arnous
An 87-year-old woman presented to the emergency department with a 2-week history of progressively worsening shortness of breath, fever and generalised myalgia. She underwent a transcatheter Portico aortic valve implantation for severe symptomatic aortic stenosis 3 months prior to this presentation. Examination revealed a temperature of 40°C and a systolic murmur in the aortic area. Inflammatory markers were elevated, and blood cultures were positive for methicillin-sensitive Staphylococcus aureus A possible diagnosis of infective endocarditis was made as one major and one minor criterion in the modified Duke criteria were fulfilled...
May 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29762649/residential-racial-isolation-and-spatial-patterning-of-type-2-diabetes-mellitus-in-durham-north-carolina
#9
Mercedes A Bravo, Rebecca Anthopolos, Rachel T Kimbro, Marie Lynn Miranda
Neighborhood characteristics such as racial segregation may be associated with type 2 diabetes mellitus, but studies have not examined these relationships using spatial models appropriate for geographically patterned health outcomes. We construct a local, spatial index of racial isolation (RI) for blacks, which measures the extent to which blacks are exposed to only one another, to estimate associations of diabetes with RI and examine how RI relates to spatial patterning in diabetes. We obtained 2007-2011 electronic health records from the Duke Medicine Enterprise Data Warehouse...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29762262/18f-fluorodeoxyglucose-positron-emission-tomography-combined-with-computed-tomography-as-a-diagnostic-tool-in-native-valve-endocarditis
#10
Ilse J E Kouijzer, Marvin A H Berrevoets, Erik H J G Aarntzen, Janneke de Vries, Arie P J van Dijk, Wim J G Oyen, Lioe-Fee de Geus-Oei, Chantal P Bleeker-Rovers
OBJECTIVE: The aim of the study was to investigate the value of F-fluorodeoxyglucose positron-emission tomography combined with computed tomography (F-FDG-PET/CT) in diagnosing native valve endocarditis (NVE). PATIENTS AND METHODS: All patients with bacteremia and suspicion of NVE between January 2013 and June 2016 were identified from the hospitals' register and retrospectively included if echocardiography and F-FDG-PET/CT were performed within 14 days. F-FDG-PET/CT scans were scored independently by two nuclear medicine physicians...
May 14, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29760082/a-cytokine-network-involving-il-36%C3%AE-il-23-and-il-22-promotes-antimicrobial-defense-and-recovery-from-intestinal-barrier-damage
#11
Vu L Ngo, Hirohito Abo, Estera Maxim, Akihito Harusato, Duke Geem, Oscar Medina-Contreras, Didier Merlin, Andrew T Gewirtz, Asma Nusrat, Timothy L Denning
The gut epithelium acts to separate host immune cells from unrestricted interactions with the microbiota and other environmental stimuli. In response to epithelial damage or dysfunction, immune cells are activated to produce interleukin (IL)-22, which is involved in repair and protection of barrier surfaces. However, the specific pathways leading to IL-22 and associated antimicrobial peptide (AMP) production in response to intestinal tissue damage remain incompletely understood. Here, we define a critical IL-36/IL-23/IL-22 cytokine network that is instrumental for AMP production and host defense...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29755627/molecular-diagnosis-of-bacterial-definite-infective-endocarditis-by-real-time-polymerase-chain-reaction
#12
Reza Faraji, Mostafa Behjati-Ardakani, Nooshin Faraji, Seyed Mohammad Moshtaghioun, Seyed Mehdi Kalantar, Ali Pedarzadeh, Hengameh Zandi, Mohammadtaghi Sarebanhassanabadi, Nastaran Ahmadi, Ali Dehghani Firoozabadi
Infective endocarditis (IE) can be diagnosed using the Duke criteria, which cannot be conclusive especially when the results of blood cultures are negative. This study aimed at using real-time polymerase chain reaction (PCR) technique to isolate bacteria present in whole blood samples of patients with definitive IE on the basis of the method designed in this study. This laboratory and test study was conducted on 20 whole blood samples taken from patients with definitive IE. Real-time PCR of the 16s rRNA was utilized to directly analyze whole blood samples to diagnose bacterial IE...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29753765/maximization-of-the-usage-of-coronary-cta-derived-plaque-information-using-a-machine-learning-based-algorithm-to-improve-risk-stratification-insights-from-the-confirm-registry
#13
Alexander R van Rosendael, Gabriel Maliakal, Kranthi K Kolli, Ashley Beecy, Subhi J Al'Aref, Aeshita Dwivedi, Gurpreet Singh, Mohit Panday, Amit Kumar, Xiaoyue Ma, Stephan Achenbach, Mouaz H Al-Mallah, Daniele Andreini, Jeroen J Bax, Daniel S Berman, Matthew J Budoff, Filippo Cademartiri, Tracy Q Callister, Hyuk-Jae Chang, Kavitha Chinnaiyan, Benjamin J W Chow, Ricardo C Cury, Augustin DeLago, Gudrun Feuchtner, Martin Hadamitzky, Joerg Hausleiter, Philipp A Kaufmann, Yong-Jin Kim, Jonathon A Leipsic, Erica Maffei, Hugo Marques, Gianluca Pontone, Gilbert L Raff, Ronen Rubinshtein, Leslee J Shaw, Todd C Villines, Heidi Gransar, Yao Lu, Erica C Jones, Jessica M Peña, Fay Y Lin, James K Min
INTRODUCTION: Machine learning (ML) is a field in computer science that demonstrated to effectively integrate clinical and imaging data for the creation of prognostic scores. The current study investigated whether a ML score, incorporating only the 16 segment coronary tree information derived from coronary computed tomography angiography (CCTA), provides enhanced risk stratification compared with current CCTA based risk scores. METHODS: From the multi-center CONFIRM registry, patients were included with complete CCTA risk score information and ≥3 year follow-up for myocardial infarction and death (primary endpoint)...
April 30, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29753700/spectrum-and-prevalence-of-genetic-predisposition-in-medulloblastoma-a-retrospective-genetic-study-and-prospective-validation-in-a-clinical-trial-cohort
#14
Sebastian M Waszak, Paul A Northcott, Ivo Buchhalter, Giles W Robinson, Christian Sutter, Susanne Groebner, Kerstin B Grund, Laurence Brugières, David T W Jones, Kristian W Pajtler, A Sorana Morrissy, Marcel Kool, Dominik Sturm, Lukas Chavez, Aurelie Ernst, Sebastian Brabetz, Michael Hain, Thomas Zichner, Maia Segura-Wang, Joachim Weischenfeldt, Tobias Rausch, Balca R Mardin, Xin Zhou, Cristina Baciu, Christian Lawerenz, Jennifer A Chan, Pascale Varlet, Lea Guerrini-Rousseau, Daniel W Fults, Wiesława Grajkowska, Peter Hauser, Nada Jabado, Young-Shin Ra, Karel Zitterbart, Suyash S Shringarpure, Francisco M De La Vega, Carlos D Bustamante, Ho-Keung Ng, Arie Perry, Tobey J MacDonald, Pablo Hernáiz Driever, Anne E Bendel, Daniel C Bowers, Geoffrey McCowage, Murali M Chintagumpala, Richard Cohn, Timothy Hassall, Gudrun Fleischhack, Tone Eggen, Finn Wesenberg, Maria Feychting, Birgitta Lannering, Joachim Schüz, Christoffer Johansen, Tina V Andersen, Martin Röösli, Claudia E Kuehni, Michael Grotzer, Kristina Kjaerheim, Camelia M Monoranu, Tenley C Archer, Elizabeth Duke, Scott L Pomeroy, Redmond Shelagh, Stephan Frank, David Sumerauer, Wolfram Scheurlen, Marina V Ryzhova, Till Milde, Christian P Kratz, David Samuel, Jinghui Zhang, David A Solomon, Marco Marra, Roland Eils, Claus R Bartram, Katja von Hoff, Stefan Rutkowski, Vijay Ramaswamy, Richard J Gilbertson, Andrey Korshunov, Michael D Taylor, Peter Lichter, David Malkin, Amar Gajjar, Jan O Korbel, Stefan M Pfister
BACKGROUND: Medulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma predisposition genes have not been defined and screening guidelines for genetic counselling and testing for paediatric patients are not available. We aimed to assess and define these genes to provide evidence for future screening guidelines. METHODS: In this international, multicentre study, we analysed patients with medulloblastoma from retrospective cohorts (International Cancer Genome Consortium [ICGC] PedBrain, Medulloblastoma Advanced Genomics International Consortium [MAGIC], and the CEFALO series) and from prospective cohorts from four clinical studies (SJMB03, SJMB12, SJYC07, and I-HIT-MED)...
May 9, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29751969/the-rate-of-false-positive-diagnosis-of-colorectal-liver-metastases-in-patients-undergoing-resection-with-the-development-of-a-novel-externally-validated-risk-score
#15
David J O'Reilly, James Hodson, Thomas W Pike, Ravi Marudanayagam, Robert P Sutcliffe, Paolo Muiesan, John Isaac, J Peter A Lodge, Darius F Mirza, Keith J Roberts
BACKGROUND: Diagnostic error in patients undergoing resection of colorectal liver metastases (CRLM) is unusual but exposes patients to unnecessary risks associated with treatment. The primary aim of this study was to determine the rate of and risk factors for a false-positive diagnosis of colorectal liver metastases in patients undergoing hepatic resection. The secondary aim was to develop and validate a risk score to predict a false-positive diagnosis. METHODS: Patients were identified from prospectively maintained databases...
May 8, 2018: Surgery
https://www.readbyqxmd.com/read/29747490/health-related-quality-of-life-perceived-social-support-and-depression-in-disease-free-survivors-who-underwent-curative-surgery-only-for-prostate-kidney-and-bladder-cancer-comparison-among-survivors-and-with-the-general-population
#16
Dong Wook Shin, Hyun Sik Park, Sang Hyub Lee, Seung Hyun Jeon, Seok Cho, Seok Ho Kang, Seung Chol Park, Jong Hyock Park, Jinsung Park
Purpose: The purpose of this study was to compare health-related quality of life (HRQoL) of disease-free prostate (PC), kidney (KC), and bladder cancer (BC) survivors with that of the general population. Materials and Methods: Our study included 331 urological cancer (UC) survivors (114 PC, 108 KC, and 109 BC) aged ≥ 50 years disease-free for at least 1 year after surgery. The control group included 1,177 subjects without a history of cancer. The HRQoL was assessed using the European Organization for Research and Treatment of Cancer QLQ-C30, the Duke-UNC Functional Social Support Questionnaire, and the Patient Health Questionnaire-9...
May 4, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29746275/the-role-of-reconstructive-surgery-after-skeletal-and-soft-tissue-sarcoma-resection
#17
Visakha Suresh, Junheng Gao, Sin-Ho Jung, Brian Brigman, William Eward, Detlev Erdmann
BACKGROUND: Skeletal and soft tissue reconstruction after sarcoma resection remains challenging. The use of advanced reconstructive techniques has been shown to improve function and increase rates of limb salvage. This study aims to analyze the utilization of plastic surgery within a multidisciplinary team approach after sarcoma resection at Duke University Medical Center from 2001 to 2014. METHODS: Medical records were reviewed to determine procedure type, postoperative complications, and tumor recurrence...
April 30, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29739255/developing-and-implementing-performance-outcome-assessments-evidentiary-methodologic-and-operational-considerations
#18
Elizabeth Richardson, Jessica Burnell, Heather R Adams, Richard W Bohannon, Elizabeth Nicole Bush, Michelle Campbell, Wen Hung Chen, Stephen Joel Coons, Elektra Papadopoulos, Bryce R Reeve, Daniel Rooks, Gregory Daniel
The use of performance outcome (PerfO) assessments to measure cognitive or physical function in drug trials presents several challenges for both sponsors and regulators, owing in part to a relative lack of scientific guidance on their development, implementation, and interpretation. In December 2016, the Duke-Margolis Center for Health Policy convened a 2-day workshop to explore the evidentiary, methodologic, and operational challenges associated with PerfO measures, and to identify potential paths to addressing these challenges...
January 1, 2018: Therapeutic Innovation & Regulatory Science
https://www.readbyqxmd.com/read/29739071/cd24-overexpression-related-to-lymph-node-invasion-and-poor-prognosis-of-colorectal-cancer
#19
Ji-Lin Wang, Chun-Rong Guo, Wen-Yu Su, Ying-Xuan Chen, Jie Xu, Jing-Yuan Fang
BACKGROUND: Cluster of differentiation 24 (CD24) has recently been reported as a biomarker for colorectal cancer. However, the clinical and prognostic significance of CD24 in colorectal cancer remains controversial. Therefore, we performed a meta-analysis to clarify this issue. METHODS: A comprehensive literature search was performed using Medline, Embase, Web of Science, and CNKI, and the statistical analysis was conducted using Stata software. RESULTS: A total of thirteen studies including 2,180 cases were included in this meta-analysis...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29737391/burly1-is-a-mouse-qtl-for-lean-body-mass-that-maps-to-a-0-8-mb-region-of-chromosome-2
#20
Cailu Lin, Brad D Fesi, Michael Marquis, Natalia P Bosak, Anna Lysenko, Mohammed Amin Koshnevisan, Fujiko F Duke, Maria L Theodorides, Theodore M Nelson, Amanda H McDaniel, Mauricio Avigdor, Charles J Arayata, Lauren Shaw, Alexander A Bachmanov, Danielle R Reed
To fine map a mouse QTL for lean body mass (Burly1), we used information from intercross, backcross, consomic, and congenic mice derived from the C57BL/6ByJ (host) and 129P3/J (donor) strains. The results from these mapping populations were concordant and showed that Burly1 is located between 151.9 and 152.7 Mb (rs33197365 to rs3700604) on mouse chromosome 2. The congenic region harboring Burly1 contains 26 protein-coding genes, 11 noncoding RNA elements (e.g., lncRNA), and 4 pseudogenes, with 1949 predicted functional variants...
May 8, 2018: Mammalian Genome: Official Journal of the International Mammalian Genome Society
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