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Muscle rupture treatment

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https://www.readbyqxmd.com/read/29771357/a-promotive-effect-for-halofuginone-on-membrane-repair-and-synaptotagmin-7-levels-in-muscle-cells-of-dysferlin-null-mice
#1
Hila Barzilai-Tutsch, Melissa Dewulf, Christophe Lamaze, Gillian Butler Browne, Mark Pines, Orna Halevy
In the absence of dysferlin, skeletal muscle cells fail to reseal properly after injury, resulting in slow progress of the dysferlinopathy muscular dystrophy. Halofuginone, a leading agent in preventing fibrosis in muscular dystrophies, was tested for its effects on membrane resealing post-injury. A hypo-osmotic shock assay on myotubes derived from wild-type and dysferlin-null (dysf-/-) mice revealed that pre-treatment with halofuginone reduces the percentage of membrane-ruptured myotubes only in dysf-/- myotubes...
May 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29754729/-femoral-pseudoaneurysms-in-drug-addicts-about-4-cases
#2
M Ben Hammamia, M Fourati, J Ziadi, F Ghedira, M Ben Mrad, R Denguir
PURPOSE: To describe the therapeutic management of false aneurysms of the femoral artery in drug addicts. PATIENTS AND METHODS: We report the cases of four drug addicts with pseudoaneurysms of the femoral artery. RESULTS: All patients were male with a mean age of 36 years. Emergency surgical treatment involved removal of the pseudoaneurysm followed by a venous graft (n=3) or patch (n=1). The post-operative period was uneventful for three patients...
May 2018: Journal de Médecine Vasculaire
https://www.readbyqxmd.com/read/29749489/effects-of-osteoprotegerin-tnfrsf11b-in-two-models-of-abdominal-aortic-aneurysms
#3
Emina Vorkapic, Anne Kunath, Dick Wågsäter
Osteoprotegerin (OPG), additionally termed tumor necrosis factor receptor superfamily member 11B, is produced by vascular smooth muscle cells (VSMCs) and endothelial cells in the vasculature, and its release may be modulated by pro‑inflammatory cytokines, including interleukin‑1β and tumor necrosis factor‑α. The present study investigated the effects of treatment with low‑dose human recombinant OPG on abdominal aortic aneurysm (AAA) development in mice. Mice were treated with 1 µg human recombinant OPG four times (or vehicle) for 2 weeks prior to inducing AAA...
April 27, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29732374/chinese-herbal-medicine-as-a-potential-treatment-of-abdominal-aortic-aneurysm
#4
Sai Wang Seto, Dennis Chang, Hosen Kiat, Ning Wang, Alan Bensoussan
Abdominal aortic aneurysm (AAA) is an irreversible condition where the abdominal aorta is dilated leading to potentially fatal consequence of aortic rupture. Multiple mechanisms are involved in the development and progression of AAA, including chronic inflammation, oxidative stress, vascular smooth muscle (VSMC) apoptosis, immune cell infiltration and extracellular matrix (ECM) degradation. Currently surgical therapies, including minimally invasive endovascular aneurysm repair (EVAR), are the only viable interventions for AAAs...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29719532/vasa-vasorum-angiogenesis-key-player-in-the-initiation-and-progression-of-atherosclerosis-and-potential-target-for-the-treatment-of-cardiovascular-disease
#5
REVIEW
Daniel G Sedding, Erin C Boyle, Jasper A F Demandt, Judith C Sluimer, Jochen Dutzmann, Axel Haverich, Johann Bauersachs
Plaque microvascularization and increased endothelial permeability are key players in the development of atherosclerosis, from the initial stages of plaque formation to the occurrence of acute cardiovascular events. First, endothelial dysfunction and increased permeability facilitate the entry of diverse inflammation-triggering molecules and particles such as low-density lipoproteins into the artery wall from the arterial lumen and vasa vasorum (VV). Recognition of entering particles by resident phagocytes in the vessel wall triggers a maladaptive inflammatory response that initiates the process of local plaque formation...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29703029/attrition-rupture-of-ulnar-nerve-in-a-patient-with-rheumatoid-elbow-arthritis-a-case-report
#6
Ayaka Kaneko, Yoichi Sugiyama, Nana Nagura, Kenji Goto, Yoshiyuki Iwase, Osamu Obayashi, Kiyohito Naito, Kazuo Kaneko
RATIONALE: Cubital tunnel syndrome has been recognized as a common pathology in rheumatoid arthritis (RA) of the elbow. We encountered a patient with RA of the elbow showing attrition rupture of the ulnar nerve. This pathology is extremely rare, and we discussed preventive measures for similar cases in the future based on our case. PATIENT CONCERNS: A 53-year-old woman, received drug treatment for RA since 30 years earlier, had numbness in the left ulnar nerve territory, dorsal interossei muscle atrophy, and resulting claw hand...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29701103/results-of-primary-repair-of-distal-triceps-tendon-ruptures-in-a-general-population
#7
G Giannicola, G Bullitta, R Rotini, L Murena, D Blonna, M Iapicca, G Restuccia, G Merolla, M Fontana, A Greco, M Scacchi, G Cinotti
Aims The aim of the study was to analyze the results of primary tendon reinsertion in acute and chronic distal triceps tendon ruptures (DTTRs) in the general population. Patients and Methods A total of 28 patients were operated on for primary DTTR reinsertions, including 21 male patients and seven female patients with a mean age of 45 years (14 to 76). Of these patients, 23 sustained an acute DTTR and five had a chronic injury. One patient had a non-simultaneous bilateral DTTR. Seven patients had DTTR-associated ipsilateral fracture or dislocation...
May 1, 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29679723/comparison-of-hook-plate-with-versus-without-double-tunnel-coracoclavicular-ligament-reconstruction-for-repair-of-acute-acromioclavicular-joint-dislocations-a-prospective-randomized-controlled-clinical-trial
#8
Jian Yin, Zhaoyang Yin, Ge Gong, Chao Zhu, Chao Sun, Xinhui Liu
PURPOSE: This study was designed to compare the surgical outcomes of a hook plate with double-tunnel coracoclavicular (CC) ligament reconstruction by conjoined tendon transfer versus single hook plate surgery for the repair of acute type of Rockwood type III and V acromioclavicular (AC) joint dislocations. METHODS: The study cohort included 62 patients with acute (within 6 weeks after trauma) Rockwood type III and V AC joint dislocations who underwent surgery from February 2012 to September 2015...
April 18, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29657436/upper-extremity-weightlifting-injuries-diagnosis-and-management
#9
REVIEW
Kayvon Golshani, Mark E Cinque, Peter O'Halloran, Kenneth Softness, Laura Keeling, J Ryan Macdonell
Common upper extremity injuries in resistance training athletes include muscle strains, ligament sprains, pectoralis major tendon ruptures, distal biceps tendon ruptures, and chronic shoulder pain and capsulolabral injuries. While each injury is unique in its specific anatomic location and mechanism, each is preventable with proper exercise technique, safety and maintenance of muscle balance. Conservative treatment is the therapeutic modality of choice and these injuries generally resolve with workout modification, appropriate recovery, anti-inflammatory medication, and physical therapy...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29649485/occult-globe-rupture-diagnostic-and-treatment-challenge
#10
REVIEW
Argyrios Chronopoulos, Jong Min Ong, Gabriele Thumann, James S Schutz
Occult globe rupture is a traumatic dehiscence of the sclera at or posterior to the rectus muscle insertions without a visible eye wall defect on slit lamp examination. Occult scleral ruptures are important because they can be difficult to diagnose, but normally require preoperative protection against external pressure to reduce risk of herniation of ocular contents through the rupture and then urgent surgical repair to restore eye wall structural integrity and achieve optimum prognosis. A deeper than normal anterior chamber with posteriorly retracted plateau iris seen immediately after acute ocular trauma is virtually pathognomonic of posterior globe dehiscence...
April 9, 2018: Survey of Ophthalmology
https://www.readbyqxmd.com/read/29623750/considerations-in-the-diagnosis-and-accelerated-return-to-sport-of-a-professional-basketball-player-with-a-triceps-surae-injury-a-case-report
#11
Philip A Anloague, Donald S Strack
Study Design Case report. Background Acute injuries of the triceps surae and Achilles tendon are common in sports. Rupture of the plantaris tendon can be challenging to diagnose. There is limited evidence detailing the diagnosis, rehabilitation, and accelerated return to sport of elite professional basketball players who have suffered calf injuries. Case Description A 25-year-old male professional basketball player sustained injury to his calf during a professional basketball game. This case report details the presumptive diagnosis, graduated progression of intervention, and return to play of a professional sports person with a likely isolated plantaris tendon tear...
April 6, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29622499/isolated-rupture-of-the-distal-plantaris-muscle
#12
Benjamin Zickmantel, Fabian Krause, Lars Frauchiger
In the present case, the plantaris tendon was ruptured in isolation and at the distal part of the tendon. An injury of the Achilles tendon, gastrocnemius muscle, or soleus muscle was not detected. To the best of our knowledge, a similar case has not yet been reported. Our case basically demonstrates that a rupture of the musculus plantaris does not have to occur at the myotendiouns junction or the muscle belly itself. The initial nonoperative treatment with physiotherapy, antiinflammatory medicine, and an early return to sports, even for this more distal plantaris tendon rupture, led to a good result...
April 2, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29615933/dexamethasone-protects-against-tourniquet-induced-acute-ischemia-reperfusion-injury-in-mouse-hindlimb
#13
Ryan M Corrick, Huiyin Tu, Dongze Zhang, Aaron N Barksdale, Robert L Muelleman, Michael C Wadman, Yu-Long Li
Extremity injuries with hemorrhage have been a significant cause of death in civilian medicine and on the battlefield. The use of a tourniquet as an intervention is necessary for treatment to an injured limb; however, the tourniquet and subsequent release results in serious acute ischemia-reperfusion (IR) injury in the skeletal muscle and neuromuscular junction (NMJ). Much evidence demonstrates that inflammation is an important factor to cause acute IR injury. To find effective therapeutic interventions for tourniquet-induced acute IR injuries, our current study investigated effect of dexamethasone, an anti-inflammatory drug, on tourniquet-induced acute IR injury in mouse hindlimb...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29566853/uterine-adenomyosis-and-adenomyoma-the-surgical-approach
#14
REVIEW
Hisao Osada
The appropriate surgical treatment of adenomyosis, a benign invasion/infiltration of endometrial glands within the underlying myometrium, remains a subject of discussion. Since 1990, in place of the classical V-shaped resection method, various kinds of surgical management have been attempted, including a uterine muscle flap method that emphasizes fertility preservation, an asymmetric dissection method, and various modified reduction methods. Laparoscopic adenomyomectomy has also become an alternative to laparotomy for surgically managing the focal type of adenomyosis, although it seems to be associated with a higher risk of uterine rupture than laparotomy...
March 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29519942/microrna-21-knockout-exacerbates-angiotensin-ii-induced-thoracic-aortic-aneurysm-and-dissection-in-mice-with-abnormal-transforming-growth-factor-%C3%AE-smad3-signaling
#15
Xiaofan Huang, Zhang Yue, Jia Wu, Jiuling Chen, Sihua Wang, Jie Wu, Linyun Ren, Anchen Zhang, Peng Deng, Ke Wang, Chuangyan Wu, Xiangchao Ding, Ping Ye, Jiahong Xia
OBJECTIVE: Thoracic aortic aneurysm and dissection (TAAD) are severe vascular conditions. Dysfunctional transforming growth factor-β (TGF-β) signaling in vascular smooth muscle cells and elevated angiotensin II (AngII) levels are implicated in the development of TAAD. In this study, we investigated whether these 2 factors lead to TAAD in a mouse model and explored the possibility of using microRNA-21 ( miR-21 ) for the treatment of TAAD. APPROACH AND RESULTS: TAAD was developed in Smad3 (mothers against decapentaplegic homolog 3) heterozygous (S3+/- ) mice infused with AngII...
May 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29494675/indoleamine-2-3-dioxygenase-knockout-limits-angiotensin-ii-induced-aneurysm-in-low-density-lipoprotein-receptor-deficient-mice-fed-with-high-fat-diet
#16
Sarvenaz Metghalchi, Marie Vandestienne, Yacine Haddad, Bruno Esposito, Julien Dairou, Alain Tedgui, Ziad Mallat, Stephane Potteaux, Soraya Taleb
AIMS: Abdominal aortic aneurysm (AAA) is an age-associated disease characterized by chronic inflammation, vascular cell apoptosis and metalloproteinase-mediated extracellular matrix degradation. Despite considerable progress in identifying targets involved in these processes, therapeutic approaches aiming to reduce aneurysm growth and rupture are still scarce. Indoleamine 2-3 dioxygenase 1 (IDO) is the first and rate-limiting enzyme involved in the conversion of tryptophan (Trp) into kynurenine (Kyn) pathway...
2018: PloS One
https://www.readbyqxmd.com/read/29486669/ultrasonographic-movement-of-the-flexor-pollicis-longus-tendon-before-and-after-removal-of-a-volar-plate-for-the-distal-radius-fracture
#17
Mitsuhiko Nanno, Norie Kodera, Yuji Tomori, Shinro Takai
INTRODUCTION: The purpose of this study was to compare the movement of the flexor pollicis longus (FPL) tendon on the distal radius during wrist and finger motions before and after removal of a volar plate in patients with distal radius fractures using transverse ultrasound and to evaluate the kinematic effects on the FPL by the removal. METHODS: Twenty-five patients with distal radius fracture were evaluated quantitatively by transverse ultrasound using coordinates for the movement of the FPL on the distal radius during wrist and finger motions before and after the plate removal...
January 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29479545/central-tendon-injuries-of-hamstring-muscles-case-series-of-operative-treatment
#18
Lasse Lempainen, Jussi Kosola, Ricard Pruna, Jordi Puigdellivol, Janne Sarimo, Pekka Niemi, Sakari Orava
Background: As compared with injuries involving muscle only, those involving the central hamstring tendon have a worse prognosis. Limited information is available regarding the surgical treatment of central tendon injuries of the hamstrings. Purpose: To describe the operative treatment and outcomes of central tendon injuries of the hamstrings among athletes. Study Design: Case series; Level of evidence, 4. Methods: Eight athletes (6 top level, 2 recreational) with central hamstring tendon injuries underwent magnetic resonance imaging and surgical treatment...
February 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29449331/lipid-lowering-therapy-with-ezetimibe-decreases-spontaneous-atherothrombotic-occlusions-in-a-rabbit-model-of-plaque-erosion-a-role-of-serum-oxysterols
#19
Katsuya Honda, Tetsuya Matoba, Yoshibumi Antoku, Jun-Ichiro Koga, Ikuyo Ichi, Kaku Nakano, Hiroyuki Tsutsui, Kensuke Egashira
OBJECTIVE: Plaque erosion is increasing its importance as one of the mechanisms of acute coronary syndromes in this statin era. However, the clinical efficacy of currently used lipid-lowering agents in the prevention of thrombotic complications associated with plaque erosion has not been clarified. Therefore, we examined the therapeutic effects of ezetimibe or rosuvastatin monotherapy on spontaneous atherothrombotic occlusion. APPROACH AND RESULTS: Femoral arteries of Japanese white rabbits, fed a high-cholesterol diet, were injured by balloon catheter, and then angiotensin II was continuously administrated...
April 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29444453/efferocytosis-in-atherosclerotic-lesions-malfunctioning-regulatory-pathways-and-control-mechanisms
#20
REVIEW
Amir Tajbakhsh, Mehdi Rezaee, Petri T Kovanen, Amirhossein Sahebkar
Atherosclerosis is a dynamic and progressive inflammatory process in the intimal layer of large and medium-sized arteries, and it is the major contributor to the atherosclerotic cardiovascular disease (ACVD), the leading cause of death worldwide. In an atherosclerotic plaque, phagocytosis of apoptotic cells occurs through an intricate process designated efferocytosis. Defective efferocytosis has emerged as a causal factor in the etiopathogenesis of atherosclerosis and its progression into overt ACVD. Both specialized phagocytes (macrophages and dendritic cells) and non-specialized cells with phagocytic capabilities (smooth muscle and endothelial cells) are involved in the efferocytotic process...
February 11, 2018: Pharmacology & Therapeutics
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