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Muscle injury treatment

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https://www.readbyqxmd.com/read/28424479/wnt-%C3%AE-catenin-signaling-pathway-a-major-player-in-the-injury-induced-fibrosis-and-dysfunction-of-the-external-anal-sphincter
#1
M Raj Rajasekaran, Sadhana Kanoo, Johnny Fu, Valmik Bhargava, Ravinder K Mittal
Wnt-β catenin is an important signaling pathway in the genesis of fibrosis in many organ systems. Our goal was to examine the role of Wnt pathway in the external anal sphincter (EAS) injury-related fibrosis and muscle dysfunction. New Zealand White female rabbits were subjected to surgical EAS myotomy and administered local injections of either a Wnt antagonist (sFRP-2; daily for 7 days) or saline. Anal canal pressure and EAS length-tension (L-T) were measured for 15 weeks after which the animals were sacrificed...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421001/defining-the-balance-between-regeneration-and-pathological-ossification-in-skeletal-muscle-following-traumatic-injury
#2
REVIEW
Owen G Davies, Yang Liu, Darren J Player, Neil R W Martin, Liam M Grover, Mark P Lewis
Heterotopic ossification (HO) is characterized by the formation of bone at atypical sites. This type of ectopic bone formation is most prominent in skeletal muscle, most frequently resulting as a consequence of physical trauma and associated with aberrant tissue regeneration. The condition is debilitating, reducing a patient's range of motion and potentially causing severe pathologies resulting from nerve and vascular compression. Despite efforts to understand the pathological processes governing HO, there remains a lack of consensus regarding the micro-environmental conditions conducive to its formation, and attempting to define the balance between muscle regeneration and pathological ossification remains complex...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28417251/irreversible-electroporation-for-the-treatment-of-rabbit-vx2-breast-cancer
#3
Wenlong Zhang, Wei Chai, Jianying Zeng, Jibing Chen, Liqi Bi, Lizhi Niu
Irreversible electroporation (IRE) is considered predominantly as a non-thermal ablative technique that uses electrical fields to permeabilize cell membranes and lead to cell death. In this study, we evaluated the efficacy of IRE in the rabbit VX2 breast cancer model. Thirty-five female New Zealand white rabbits were inoculated against VX2 breast cancer cells. The rabbits were randomly divided into two groups: a control group of 15 rabbits and an IRE treatment group of 20 rabbits. Treatment and treatment outcome were evaluated by computerized tomography (CT) scan (plain or contrast enhanced), tumor growth curves and pathological examination including H&E, TUNEL, PCNA and CD31 staining...
June 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/28409883/melanocortin-4-receptor-activation-attenuates-mitochondrial-dysfunction-in-skeletal-muscle-of-diabetic-rats
#4
Hao-Hao Zhang, Jiao Liu, Gui-Jun Qin, Xia-Lian Li, Pei-Jie Du, Xiao Hao, Tian-Tian Tian, Jing- Wu, Meng- Yun, Yan-Hui Bai
Backgroud: A previous study has confirmed that the central melanocortin system was able to mediate skeletal muscle AMP-activated protein kinase (AMPK) activation in mice fed a high-fat diet, while activation of the AMPK signaling pathway significantly induced mitochondrial biogenesis. Our hypothesis was that melanocortin 4 receptor (MC4R) was involved in the development of skeletal muscle injury in diabetic rats. METHODS: In this study, we treated diabetic rats intracerebroventricularly with MC4R agonist R027-3225 or antagonist SHU9119, respectively...
April 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28409133/evaluation-of-the-functional-results-after-rotator-cuff-arthroscopic-repair-with-the-suture-bridge-technique
#5
Alberto Naoki Miyazaki, Pedro Doneux Santos, Guilherme do Val Sella, Caio Santos Checchia, Thiago Roncoletta Salata, Sergio Luiz Checchia
OBJECTIVE: To evaluate the results of arthroscopic treatment of large and extensive rotator cuff injuries (RCI) that involved the supra and infraspinatus muscles using the suture bridge (SB) technique. METHODS: Between July 2010 and November 2014, 37 patients with RCI who were treated with SB technique were evaluated. The study included all patients with a minimum follow-up of 12 months who underwent primary surgery of the shoulder. Twenty-four patients were male and 13 were female...
March 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28409130/acute-distal-biceps-ruptures-single-incision-repair-by-use-of-suture-anchors
#6
Rafael Almeida Maciel, Priscilla Silva Costa, Eduardo Antônio Figueiredo, Paulo Santoro Belangero, Alberto de Castro Pochini, Benno Ejnisman
OBJECTIVE: Clinical and functional assessment of the surgical treatment for acute injury of the distal insertion of the biceps brachial performed with a surgical technique using a single incision in proximal forearm and fixation with suture anchors in the radial tuberosity. METHODS: This study reviewed the medical records of patients who underwent surgical treatment of distal biceps injury during the period between January 2008 and July 2014. In a mean follow-up of 12 months, 22 patients with complete and acute injury, diagnosed through physical examination and imaging studies, were functionally assessed in the postoperative period regarding the range of motion (degrees of flexion-extension and pronation-supination), the presence of pain (VAS), the Andrews Carson-score, and the Mayo Elbow Performance Score (MEPS)...
March 2017: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/28409035/the-use-of-coupled-plasma-filtration-adsorption-in-traumatic-rhabdomyolysis
#7
Mario Pezzi, Silvia Renda, Anna Maria Giglio, Anna Maria Scozzafava, Simona Paola Tiburzi, Patrizia Casella, Fabrizio Iannelli, Mario Verre
Severe musculoskeletal injuries induce the release of sarcoplasmic elements such as muscle enzymes, potassium, and myoglobin in the systemic circulation. The circulating myoglobin damages the glomerulus and renal tubules. Conventional haemodialysis is not able to remove myoglobin, due to its high molecular weight (17,8 kilodaltons [kDa]). We treated four traumatic rhabdomyolysis patients with Coupled Plasma Filtration Adsorption (CPFA) in order to remove myoglobin followed by 14 hours of Continuous Veno-Venous Hemofiltration (CVVH)...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/28403495/-diagnosis-and-therapeutic-management-in-kidney-ureter-and-bladder-trauma
#8
Karin Hirsch, Marco Heinz, Bernd Wullich
Trauma refers to the destruction of tissues or organs by external forces and it is the most common cause of mortality and morbidity in children (1, 2). Injuries of the genitourinary tract may be the result of blunt (falls, sport injuries, motor vehicle accidents and sexual abuse) or penetrating (stab wounds, gun shots, falling onto sharp objects) injuries. The genitourinary tract is significantly injured in 2.9% of paediatric trauma patients 4.In the paediatric population, the kidney is the most affected organ in the genitourinary tract (>60% of all genitourinary tract injuries) 4...
February 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28396046/minocycline-prevents-muscular-pain-hypersensitivity-and-cutaneous-allodynia-produced-by-repeated-intramuscular-injections-of-hypertonic-saline-in-healthy-human-participants
#9
Mohamad Samir Samour, Saad Saulat Nagi, Peter John Shortland, David Anthony Mahns
Minocycline, a glial suppressor, prevents behavioural hypersensitivities in animal models of peripheral nerve injury. However clinical trials of minocycline in human studies have produced mixed results. This study addressed two questions: can repeated injections of hypertonic saline (HS) in humans induce persistent hypersensitivity? Can pre-treatment with minocycline, a tetracycline antibiotic with microglial inhibitory effects, prevent the onset of hypersensitivity? Twenty seven healthy participants took part in this double-blind, placebo-controlled study, consisting of six test sessions across 2 weeks...
April 7, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28390182/early-local-delivery-of-vancomycin-suppresses-ectopic-bone-formation-in-a-rat-model-of-trauma-induced-heterotopic-ossification
#10
Jonathan G Seavey, Benjamin M Wheatley, Gabriel J Pavey, Allison M Tomasino, Margaret A Hanson, Erin M Sanders, Devaveena Dey, Kaitlyn L Moss, Benjamin K Potter, Jonathan A Forsberg, Ammar T Qureshi, Thomas A Davis
Heterotopic ossification (HO) is a debilitating sequela of high-energy injuries. It frequently requires surgical excision once symptomatic and there is no practical prophylaxis for combat-injured patients. In this study, we examined the effect of local vancomycin powder on HO formation in a small animal model of blast-related, post-traumatic HO. Male Sprague-Dawley rats were subjected to a polytraumatic extremity injury and amputation with or without methicillin-resistant Staphylococcus aureus infection. Animals were randomized to receive a single local application of vancomycin (20 mg/kg) at the time of injury (POD-0, n = 34) or on postoperative day-3 (POD-3, n = 11)...
April 8, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28388232/increasing-and-decreasing-pain-causes-acute-responses-of-strength-and-running-mechanics-in-patellofemoral-pain
#11
David M Bazett-Jones, Wendy Huddleston, Stephen Cobb, Kristian O'Connor, Jennifer E Earl-Boehm
CONTEXT:   Patellofemoral pain (PFP) is typically exacerbated by repetitive activities that load the patellofemoral joint, such as running. Understanding the mediating effects of changes in pain in individuals with PFP might inform injury progression, rehabilitation, or both. OBJECTIVE:   To investigate the effects of changing pain on muscular strength and running biomechanics in those with PFP. DESIGN:   Crossover study. SETTING:   University research laboratory...
April 7, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28386340/lipoxin-a4-pretreatment-mitigates-skeletal-muscle-ischemia-reperfusion-injury-in-rats
#12
Haiyang Zong, Xinghui Li, Haodong Lin, Chunlin Hou, Fenfen Ma
The aim of this study was to investigate the protective effects and underlying anti-oxidative molecular mechanism of lipoxin A4 (LA4) in rats with ischemia/reperfusion (I/R)-injured skeletal muscle. A rat model of I/R-injured skeletal muscle was obtained by subjecting rats to a 3-h ligation of the right femoral artery followed by 3 h of reperfusion. Treatment with LA4 significantly ameliorated histological damage scores in I/R-injured skeletal muscle. LA4 treatment resulted in remarkable decreases in the wet weight/dry weight ratio (W/D ratio), inflammatory response, oxidative stress, and cell apoptosis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28382782/fatty-acid-binding-protein-4-regulates-fatty-infiltration-after-rotator-cuff-tear-by-hypoxia-inducible-factor-1-in-mice
#13
Yong-Soo Lee, Ja-Yeon Kim, Kyung-Soo Oh, Seok Won Chung
BACKGROUND: Fatty infiltration in skeletal muscle is directly linked to loss of muscle strength and is associated with various adverse physical outcomes such as muscle atrophy, inflammation, insulin resistance, mobility impairments, and even mortality in the elderly. Aging, mechanical unloading, muscle injury, and hormonal imbalance are main causes of muscle fat accumulation, and the fat cells are derived from muscle stem cells via adipogenic differentiation. However, the pathogenesis and molecular mechanisms of fatty infiltration in muscles are still not fully defined...
April 5, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28376941/systematic-evaluation-of-skeletal-fractures-caused-by-induction-of-electroconvulsive-seizures-in-rat-state-a-need-for-attention-and-refinement-of-the-procedure
#14
Maria Ekemohn, Marie Kjær Nielsen, Matilda Grahm, Anders Tingström, Birgitte Kousholt, Gregers Wegener, Cecilie Bay-Richter
OBJECTIVE: Electroconvulsive therapy (ECT) is one of the most efficient treatments for major depression. Electroconvulsive seizures (ECS), the animal model of ECT, is widely used to study both mechanisms of action and adverse effects of ECT. As the treatment itself serves as an instant anaesthetic and anaesthetic agents may affect memory functions and behaviour, ECS is traditionally administered without muscle relaxation and anaesthesia. A major problem of unmodified ECS, which has only been addressed peripherally in the literature, is that some animals sustain spinal fractures and subsequent hind leg paralysis (paraplegia)...
April 5, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/28373641/influence-of-nitric-oxide-generated-through-microwave-plasma-on-l6-skeletal-muscle-cell-myogenesis-via-oxidative-signaling-pathways
#15
Naresh Kumar, Priyanka Shaw, Han Sup Uhm, Eun Ha Choi, Pankaj Attri
Myogenic precursors are myoblasts that have a potency to differentiate into muscle fibers on injury and maintain the regenerative power of skeletal muscle. However, the roles of exogenous nitric oxide (NO) in muscle development and myoblast differentiation are largely unknown. Therefore, in this study, we examined the effects of exogenous NO generated by a microwave plasma torch on rat myoblastic L6 cell proliferation and differentiation. We observed that the differentiation of L6 myogenic precursor cells into myotubes was significantly enhanced after NO treatment...
April 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28372522/skeletal-myoblast-seeded-vascularized-tissue-scaffolds-in-the-treatment-of-a-large-volumetric-muscle-defect-in-the-rat-biceps-femoris-muscle
#16
Mon Tzu Li, Marissa Ruehle, Hazel Stevens, Nick Servies, Nick Willett, Sukhita Karthikeyakannan, Gordon L Warren, Robert Guldberg, Laxminarayanan N Krishnan
High velocity impact injuries can often result in loss of large skeletal muscle mass, creating defects devoid of matrix, cells, and vasculature. Functional regeneration within these regions of large volumetric muscle loss (VML) continues to be a significant clinical challenge. Large cell-seeded, space-filling tissue engineered constructs that may augment regeneration require adequate vascularization to maintain cell viability. However, the long-term effect of improved vascularization and the effect of addition of myoblasts to vascularized constructs have not been determined in large VMLs...
April 3, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28369286/a-2-year-follow-up-after-a-2-year-rct-with-vitamin-d-and-exercise-effects-on-falls-injurious-falls-and-physical-functioning-among-older-women
#17
Kirsti Uusi-Rasi, Radhika Patil, Saija Karinkanta, Pekka Kannus, Kari Tokola, Christel Lamberg-Allardt, Harri Sievänen
Background: Both exercise and vitamin D are recommended means to prevent falls among older adults, but their combined effects on fall-induced injuries are scarcely studied. Methods: A 2-year follow-up of a previous 2-year randomized controlled trial with vitamin D and exercise (Ex) of 409 older home-dwelling women using a factorial 2 × 2 design (D-Ex-, D+Ex-, D-Ex+, D+Ex+). Besides monthly fall diaries, femoral neck bone mineral density (fn-BMD), and physical functioning were assessed at 1 and 2 years after the intervention...
March 21, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28367118/neurologic-correlates-of-gait-abnormalities-in-cerebral-palsy-implications-for-treatment
#18
REVIEW
Joanne Zhou, Erin E Butler, Jessica Rose
Cerebral palsy (CP) is the most common movement disorder in children. A diagnosis of CP is often made based on abnormal muscle tone or posture, a delay in reaching motor milestones, or the presence of gait abnormalities in young children. Neuroimaging of high-risk neonates and of children diagnosed with CP have identified patterns of neurologic injury associated with CP, however, the neural underpinnings of common gait abnormalities remain largely uncharacterized. Here, we review the nature of the brain injury in CP, as well as the neuromuscular deficits and subsequent gait abnormalities common among children with CP...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28366437/mechanical-histological-and-functional-properties-remain-inferior-in-conservatively-treated-achilles-tendons-in-rodents-long-term-evaluation
#19
Benjamin R Freedman, George W Fryhofer, Nabeel S Salka, Harina A Raja, Cody D Hillin, Courtney A Nuss, Daniel C Farber, Louis J Soslowsky
Conservative treatment (non-operative) of Achilles tendon ruptures is suggested to produce equivalent capacity for return to function; however, long term results and the role of return to activity (RTA) for this treatment paradigm remain unclear. Therefore, the objective of this study was to evaluate the long term response of conservatively treated Achilles tendons in rodents with varied RTA. Sprague Dawley rats (n=32) received unilateral blunt transection of the Achilles tendon followed by randomization into groups that returned to activity after 1-week (RTA1) or 3-weeks (RTA3) of limb casting in plantarflexion, before being euthanized at 16-weeks post-injury...
May 3, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28364032/sodium-glucose-transporter-2-inhibition-has-no-renoprotective-effects-on-non-diabetic-chronic-kidney-disease
#20
Qiuyue Ma, Stefanie Steiger, Hans-Joachim Anders
Sodium glucose transporter (SGLT)-2 inhibition has renoprotective effects in diabetic kidney disease. Whether similar effects can be achieved also in non-diabetic kidney disease is speculative. Chronic kidney disease was induced in C57BL/6N mice by feeding an oxalate-rich diet for 14 days, known to induce nephrocalcinosis-related tubular atrophy and interstitial fibrosis without directly affecting the glomerular compartment. Empagliflozin treatment started from day 0 of oxalate feeding had no effect on the decline of glomerular filtration rate, crystal deposition, blood urea nitrogen or serum creatinine levels on day 7 and 14...
April 2017: Physiological Reports
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