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Muscle injury treatment

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https://www.readbyqxmd.com/read/29774991/aggregate-mesenchymal-stem-cell-delivery-ameliorates-the-regenerative-niche-for-muscle-repair
#1
Marissa A Ruehle, Hazel Y Stevens, Aaron M Beedle, Robert E Guldberg, Jarrod A Call
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease due to the absence of the dystrophin protein from the muscle cell membrane which renders the muscle susceptible to continuous damage. In DMD patients, muscle weakness, together with cycles of degeneration/regeneration and replacement with non-contractile tissue, limit mobility and lifespan. Since the loss of dystrophin result in loss of polarity and a reduction in the number of self-renewing satellite cells, it is postulated that these patients could achieve an improved quality of life if delivered cells could restore satellite cell function...
May 18, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29773764/degloving-lower-leg-injury-the-importance-of-additional-treatment-negative-pressure-and-hyperbaric-oxygen-therapy
#2
Piotr Stabryła, Joanna Kulińska, Łukasz Warchoł, Anna Kasielska-Trojan, Wojciech Gaszyński, Bogusław Antoszewski
Degloving injury poses a severe therapeutic challenge concerning both trauma and plastic surgery. The injury involves separation of skin and subcutaneous tissue from fascia and muscles. Treatment is often long-lasting and brings unsatisfying results due to the extent of damage, risk of infection and massive blood loss. In this article, we present the management and therapeutic outcomes of a patient admitted due to the degloving injury of the lower extremity caused by workplace accident. We described the complexity of treatment including surgical intervention as well as additional treatment, which combined brought good esthetic outcome...
April 30, 2018: Polski Przeglad Chirurgiczny
https://www.readbyqxmd.com/read/29772187/platelet-rich-plasma-releasate-promotes-regeneration-and-decreases-inflammation-and-apoptosis-of-injured-skeletal-muscle
#3
Wen-Chung Tsai, Tung-Yang Yu, Gwo-Jyh Chang, Li-Ping Lin, Miao-Sui Lin, Jong-Hwei S Pang
BACKGROUND: Platelet-rich plasma (PRP) contains various cytokines and growth factors that may be beneficial to the healing process of injured muscle. Based on the authors' previous study, PRP releasate can promote proliferation and migration of skeletal muscle cells in vitro, so animal studies are performed to support the use of PRP to treat muscle injury in vivo. PURPOSE: To investigate the effect of PRP releasate on regeneration of injured muscle, as well as its effect on inflammatory reaction and cell apoptosis, in the early stages of the muscle-healing process...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29771357/a-promotive-effect-for-halofuginone-on-membrane-repair-and-synaptotagmin-7-levels-in-muscle-cells-of-dysferlin-null-mice
#4
Hila Barzilai-Tutsch, Melissa Dewulf, Christophe Lamaze, Gillian Butler Browne, Mark Pines, Orna Halevy
In the absence of dysferlin, skeletal muscle cells fail to reseal properly after injury, resulting in slow progress of the dysferlinopathy muscular dystrophy. Halofuginone, a leading agent in preventing fibrosis in muscular dystrophies, was tested for its effects on membrane resealing post-injury. A hypo-osmotic shock assay on myotubes derived from wild-type and dysferlin-null (dysf-/-) mice revealed that pre-treatment with halofuginone reduces the percentage of membrane-ruptured myotubes only in dysf-/- myotubes...
May 16, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29771121/effects-of-geniposide-from-gardenia-fruit-pomace-on-skeletal-muscle-fibrosis
#5
Haiou Pan, Yan Li, Hai Feng Qian, Xiguang Qi, Gangcheng Wu, Hui Zhang, Meijuan Xu, Zhiming Rao, Jinlong Li, Li Wang, Hao Ying
Geniposide is the main bioactive constituent of Gardenia fruit. Skeletal muscle fibrosis is a common and irreversible damage process. Numerous studies have shown that geniposide could improve many chronic diseases including metabolic syndrome and tumor. However, the effects of geniposide on skeletal muscle fibrosis are still poorly understood. Here, we found that crude extracts from Gardenia fruit pomace could significantly decrease the expressions of pro-fibrotic genes in vitro. Moreover, geniposide could also reverse pro-fibrotic gene expression induced by TGF- and Smad4, a regulator of skeletal muscle fibrosis...
May 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29764020/-effect-of-cricothyroid-and-thyroarytenoid-muscle-botulinum-toxin-injection-on-patients-with-dyspnea-caused-by-bilateral-recurrent-laryngeal-nerve-paresis
#6
X L Xu, J M Lai, T Qiu, Y L Ma, Y C Jiao, P Y Zhuang
Objective: To discuss the clinical effect of small dose of botulinum toxin injection in cricothyroid muscle and thyroarytenoid muscle on patients with incomplete bilateral recurrent laryngeal nerve paresis. Methods: Six patients were selected with Ⅰor Ⅱ or Ⅲ degree of dyspnea diagnosed as bilateral recurrent laryngeal nerve injury by laryngeal electromyography, and small dose of botulinum toxin injection was performed in cricothyroid muscle and thyroarytenoid muscle as a treatment. Degree of dyspnea was assessed one month before and after the treatment, and the stroboscopic laryngoscope results, acoustic parameters and CT image of the patients were collected in the 6 patients...
May 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29760552/patients-receiving-chiropractic-care-in-a-neurorehabilitation-hospital-a-descriptive-study
#7
Robert D Vining, Stacie A Salsbury, W Carl Cooley, Donna Gosselin, Lance Corber, Christine M Goertz
Objectives: Individuals rehabilitating from complex neurological injury require a multidisciplinary approach, which typically does not include chiropractic care. This study describes inpatients receiving multidisciplinary rehabilitation including chiropractic care for brain injury, spinal cord injury (SCI), stroke, and other complex neurological conditions. Design: Chiropractic services were integrated into Crotched Mountain Specialty Hospital (CMSH) through this project...
2018: Journal of Multidisciplinary Healthcare
https://www.readbyqxmd.com/read/29760339/the-potential-antifibrotic-impact-of-apocynin-and-alpha-lipoic-acid-in-concanavalin-a-induced-liver-fibrosis-in-rats-role-of-nadph-oxidases-1-and-4
#8
Mostafa R Fayed, Reem N El-Naga, El-Sayed Akool, Ebtehal El-Demerdash
Liver fibrosis results from chronic inflammation that precipitates excessive accumulation of extracellular matrix. Oxidative stress is involved in its pathogenesis. This study aimed to elucidate the potential antifibrotic effect of the NADPH oxidase (NOX) inhibitor, apocynin against concanavalin A (ConA)-induced immunological model of liver fibrosis, and to investigate the ability of the antioxidant, alpha-lipoic acid (α-LA) to potentiate this effect. Rats were treated with apocynin and/or α-LA for six weeks...
2018: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29759920/dysphonia-perceived-control-and-psychosocial-distress-a-qualitative-study
#9
Stephanie Misono, Caroline Haut, Liza Meredith, Patricia A Frazier, Ali Stockness, Deirdre D Michael, Lisa Butcher, Eileen M Harwood
OBJECTIVES: The purpose of this qualitative study was to examine relationships between psychological factors, particularly perceived control, and voice symptoms in adults seeking treatment for a voice problem. METHODS: Semistructured interviews of adult patients with a clinical diagnosis of muscle tension dysphonia were conducted and transcribed. Follow-up interviews were conducted as needed for further information or clarification. A multidisciplinary team analyzed interview content using inductive techniques...
May 11, 2018: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/29759081/comparative-study-of-the-paraspinal-muscles-after-ovf-between-the-insufficient-union-and-sufficient-union-using-mri
#10
Marina Katsu, Tetsuro Ohba, Shigeto Ebata, Hirotaka Haro
BACKGROUND: Identification of poor prognostic factors for OVF is important but has not yet been clearly established. Despite paraspinal muscles could play an important role in the etiology of OVF, what influence time-dependent changes in paraspinal muscles have after OVF, and the impact on conservative treatments for patients who have an OVF remain largely unknown. The purposes of this study were to (1) evaluate time-dependent changes of the paraspinal musculature using MRI after injury in patients with osteoporotic vertebral fractures (OVFs), and (2) compare paraspinal muscles between conservatively treated patients with OVF who have successful union and those failed to conservative treatment...
May 14, 2018: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29755852/high-frequency-generator-in-wound-healing-of-marjolin-s-ulcer-after-carcinoma-resection
#11
Pascale Mutti Tacani, Rogério Eduardo Tacani, Aline Fernanda Perez Machado, Débora Montezello, João Carlos Guedes Sampaio Góes, Angela Gonçalves Marx, Richard Eloin Liebano
Marjolin's ulcers (MU) are skin malignancies that form over burn injuries. These very aggressive ulcers can result in functional and wound healing impairment, and require a well thought out treatment plan. Physiotherapy offers resources to help promote recovery of these patients, as described in this case report, in which the patient with a history of burn in the lower limbs evolved to malignancy 32 years later. This patient underwent tumor resection of the left foot, with recurrence and lymphadenectomy . Physical therapy included the application of high-frequency generator (HFG) for wound healing and exercises for functional recovery...
May 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29750541/fatty-infiltration-is-a-prognostic-marker-of-muscle-function-after-rotator-cuff-tear
#12
Ana P Valencia, Jim K Lai, Shama R Iyer, Katherine L Mistretta, Espen E Spangenburg, Derik L Davis, Richard M Lovering, Mohit N Gilotra
BACKGROUND: Massive rotator cuff tears (RCTs) begin as primary tendon injuries and cause a myriad of changes in the muscle, including atrophy, fatty infiltration (FI), and fibrosis. However, it is unclear which changes are most closely associated with muscle function. PURPOSE: To determine if FI of the supraspinatus muscle after acute RCT relates to short-term changes in muscle function. STUDY DESIGN: Controlled laboratory study. METHODS: Unilateral RCTs were induced in female rabbits via tenotomy of the supraspinatus and infraspinatus...
May 1, 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29750298/role-of-smad3-signaling-in-the-epithelial%C3%A2-mesenchymal-transition-of-the-lens-epithelium-following-injury
#13
Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Transforming growth factor‑β (TGF‑β) is important in the development of posterior capsule opacification (PCO), and inhibition of the TGF‑β pathway may represent a novel method of treating PCO. Drosophila protein, mothers against decapentaplegic homolog 3 (Smad3) is a phosphorylated receptor‑activated Smad required for the transmission of TGF‑β signals. Smad3 knockout (KO) disturbs the activation of TGF‑β signaling, thus inhibiting the onset of PCO. In the present study, lens epithelial cell (LEC) damage induced by extracapsular cataract extraction was simulated by puncture of the anterior capsule using a 26‑gauge hypodermic needle...
May 9, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29747942/avulsion-fracture-of-the-lesser-trochanter-in-adolescents
#14
Thomas Ruffing, Tilmann Rückauer, Frederic Bludau, Alexander Hofmann, Markus Muhm, Arnold J Suda
INTRODUCTION: Avulsion fractures of the lesser trochanter in adolescents are rare. They are a result of a sudden and forceful contraction of the iliopsoas muscle. Functional results in the medium term after non-operative treatment are unknown. Therefore we aimed to report these in the present study. MATERIALS AND METHODS: A retrospective two-center study was performed in a case series treated between 2011 and 2017. All adolescents with an acute avulsion fracture of the lesser trochanter were included...
May 4, 2018: Injury
https://www.readbyqxmd.com/read/29747248/-experience-of-successful-rescue-from-5-cases-of-internal-carotid-artery-injury-during-transnasal-endoscopic-skull-base-surgery
#15
F Yin, J W Sun, Y F Wang, T Guo, W Zhao
Objective: To investigate the cause and urgent management of internal carotid artery injury during transnasal endoscopic skull base surgery. Methods: Five cases of internal carotid artery injury encountered during transnasal endoscopic skull base surgery in Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of University of Science of Technology of China, Anhui Provincial Hospital from December 2010 to July 2017 were analysed retrospectively. There were 2 cases of adenoid cystic carcinoma, 1 case of salivary gland-type adenocarcinoma, 1 case of petrous apex cholesterol granulomas and 1 case of squamous carcinoma...
April 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29743983/chemotherapeutic-drugs-and-mitochondrial-dysfunction-focus-on-doxorubicin-trastuzumab-and-sunitinib
#16
REVIEW
Stefania Gorini, Antonella De Angelis, Liberato Berrino, Natalia Malara, Giuseppe Rosano, Elisabetta Ferraro
Many cancer therapies produce toxic side effects whose molecular mechanisms await full elucidation. The most feared and studied side effect of chemotherapeutic drugs is cardiotoxicity. Also, skeletal muscle physiology impairment has been recorded after many chemotherapeutical treatments. However, only doxorubicin has been extensively studied for its side effects on skeletal muscle. Chemotherapeutic-induced adverse side effects are, in many cases, mediated by mitochondrial damage. In particular, trastuzumab and sunitinib toxicity is mainly associated with mitochondria impairment and is mostly reversible...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29738818/microrna-132-targeting-pten-contributes-to-cilostazol-promoted-vascular-smooth-muscle-cell-differentiation
#17
Wei-Jan Chen, Ying-Hwa Chen, Yu-Juei Hsu, Kwang-Huei Lin, Yung-Hsin Yeh
BACKGROUND AND AIMS: Cilostazol, beyond its antiplatelet effect, is also capable of promoting vascular smooth muscle cell (VSMC) differentiation. The aim of this study was to explore the potential role of PTEN, known to associate with VSMC differentiation, and its related microRNA (miRNA) in cilostazol-dependent effects. METHODS AND RESULTS: Microarray analysis in balloon-injured rat carotid arteries comparing with and without balloon injury revealed that miR-132 was differentially expressed...
April 26, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29734889/oberlin-s-transfer-long-term-outcomes
#18
Karlis Verdins, Martins Kapickis
BACKGROUND: Brachial plexus injury is very commonly associated with road traffic accidents, and frequently affects young adults, causing significant disability and impact on quality of life. The successful treatment of upper plexus injury with the Oberlin technique to restore elbow flexion with good functional results. METHODS: We retrieved the records of all patients with upper plexus injury who underwent Oberlin transfer operation between March 2007 and July 2012...
June 2018: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/29734192/mir-27b-promotes-muscle-development-by-inhibiting-mdfi-expression
#19
Lianjie Hou, Jian Xu, Yiren Jiao, Huaqin Li, Zhicheng Pan, Junli Duan, Ting Gu, Chingyuan Hu, Chong Wang
BACKGROUND/AIMS: Skeletal muscle plays an essential role in the body movement. However, injuries to the skeletal muscle are common. Lifelong maintenance of skeletal muscle function largely depends on preserving the regenerative capacity of muscle. Muscle satellite cells proliferation, differentiation, and myoblast fusion play an important role in muscle regeneration after injury. Therefore, understanding of the mechanisms associated with muscle development during muscle regeneration is essential for devising the alternative treatments for muscle injury in the future...
May 3, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29732218/repair-of-recto-urethral-fistula-with-urethral-augmentation-by-buccal-mucosal-graft-and-gracilis-muscle-flap-interposition-our-experience
#20
Vikram Prabha, Vishal Kadeli
Introduction: Recto-urethral fistula (RUF) is a relatively rare surgical condition, the treatment of which is quite challenging. There are many causes of RUF, but 60% of them are iatrogenic following open prostatectomies, radiotherapy, brachytherapy, urethral instrumentation etc. We present a series of six cases treated at our institution. Material and methods: A retrospective study of all six patients with recto-urethral fistula treated at our centre between 2011 and 2016 was performed...
2018: Central European Journal of Urology
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