Malte Gronewold, Isabel Grote, Stephan Bartels, Henriette Christgen, Leonie D Kandt, Maria Jose Brito, Gàbor Cserni, Maximilian E Daemmrich, Franz Fogt, Burkhard M Helmke, Natalie Ter Hoeve, Corinna Lang-Schwarz, Michael Vieth, Axel Wellmann, Elna Kuehnle, Ulf Kulik, Gesa Riedel, Tanja Reineke-Plaass, Ulrich Lehmann, Thijs Koorman, Patrick Wb Derksen, Hans Kreipe, Matthias Christgen
Invasive lobular carcinoma (ILC) is a special breast cancer type characterized by noncohesive growth and E-cadherin loss. Focal activation of P-cadherin expression in tumor cells that are deficient for E-cadherin occurs in a subset of ILCs. Switching from an E-cadherin deficient to P-cadherin proficient status (EPS) partially restores cell-cell adhesion leading to the formation of cohesive tubular elements. It is unknown what conditions control EPS. Here, we report on EPS in ILC metastases in the large bowel...
March 2024: Journal of Pathology. Clinical Research