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https://www.readbyqxmd.com/read/28335291/multispectral-emissions-of-lanthanide-doped-gadolinium-oxide-nanophosphors-for-cathodoluminescence-and-near-infrared-upconversion-downconversion-imaging
#1
Doan Thi Kim Dung, Shoichiro Fukushima, Taichi Furukawa, Hirohiko Niioka, Takumi Sannomiya, Kaori Kobayashi, Hiroshi Yukawa, Yoshinobu Baba, Mamoru Hashimoto, Jun Miyake
Comprehensive imaging of a biological individual can be achieved by utilizing the variation in spatial resolution, the scale of cathodoluminescence (CL), and near-infrared (NIR), as favored by imaging probe Gd₂O₃ co-doped lanthanide nanophosphors (NPPs). A series of Gd₂O₃:Ln(3+)/Yb(3+) (Ln(3+): Tm(3+), Ho(3+), Er(3+)) NPPs with multispectral emission are prepared by the sol-gel method. The NPPs show a wide range of emissions spanning from the visible to the NIR region under 980 nm excitation. The dependence of the upconverting (UC)/downconverting (DC) emission intensity on the dopant ratio is investigated...
September 6, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334332/ultraminiature-optical-design-for-multispectral-fluorescence-imaging-endoscopes
#2
Tyler H Tate, Molly Keenan, John Black, Urs Utzinger, Jennifer K Barton
No abstract text is available yet for this article.
March 1, 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28333622/constrained-inversion-and-spectral-unmixing-in-multispectral-optoacoustic-tomography
#3
Lu Ding, Xose Luis Dean Ben, Neal C Burton, Robert W Sobol, Vasilis Ntziachristos, Daniel Razansky
Accurate extraction of physical and biochemical parameters from optoacoustic images is often impeded due to the use of unrigorous inversion schemes, incomplete tomographic detection coverage or other experimental factors that cannot be readily accounted for during the image acquisition and reconstruction process. For instance, inaccurate assumptions in the physical forward model may lead to negative optical absorption values in the reconstructed images. Any artifacts present in the single wavelength optoacoustic images can be significantly aggravated when performing a two-step reconstruction consisting in acoustic inversion and spectral unmixing aimed at rendering the distributions of spectrally-distinct absorbers...
March 22, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28332777/diagnostic-performance-of-the-melafind-device-in-a-real-life-clinical-setting
#4
Christine Fink, Claudia Jaeger, Katharina Jaeger, Holger A Haenssle
BACKGROUND: MelaFind is a multispectral computer vision system intended to -provide additional information on melanocytic lesions suspected of being melanoma by -objectively assessing their three-dimensional morphology. OBJECTIVES: Analysis of the diagnostic performance of MelaFind in a real-life clinical setting. PATIENTS AND METHODS: In this observational study, 360 pigmented skin lesions (PSL) in 111 patients were assessed by office-based dermatologists using MelaFind...
March 23, 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28314998/multispectral-images-of-flowers-reveal-the-adaptive-significance-of-using-long-wavelength-sensitive-receptors-for-edge-detection-in-bees
#5
Vera Vasas, Daniel Hanley, Peter G Kevan, Lars Chittka
Many pollinating insects acquire their entire nutrition from visiting flowers, and they must therefore be efficient both at detecting flowers and at recognizing familiar rewarding flower types. A crucial first step in recognition is the identification of edges and the segmentation of the visual field into areas that belong together. Honeybees and bumblebees acquire visual information through three types of photoreceptors; however, they only use a single receptor type-the one sensitive to longer wavelengths-for edge detection and movement detection...
March 17, 2017: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/28301720/terrylenediimide-based-intrinsic-theranostic-nanomedicines-with-high-photothermal-conversion-efficiency-for-photoacoustic-imaging-guided-cancer-therapy
#6
Shaobo Zhang, Weisheng Guo, Jie Wei, Chan Li, Xing-Jie Liang, Meizhen Yin
Activatable theranostic nanomedicines involved in photothermal therapy (PTT) have received constant attention as promising alternatives to traditional therapies in clinic. However, the theranostic nanomedicines widely suffer from instability and complicated nanostructures, which hamper potential clinical applications. Herein, we demonstrated a terrylenediimide-poly(acrylic acid) (TPA)-based nanomedicine (TNM) platform used as an intrinsic theranostic agent. As an exploratory paradigm in seeking biomedical applications, terrylenediimide (TDI) was modified with poly(acrylic acid)s (PAAs), resulting in eight-armed, star-like TPAs composed of an outside hydrophilic PAA corona and an inner hydrophobic TDI core...
March 16, 2017: ACS Nano
https://www.readbyqxmd.com/read/28294066/mechanisms-of-melatonin-in-alleviating-alzheimer-s-disease
#7
Mayuri Shukla, Parichart Boontem, Russel J Reiter, Jutamaad Satayavivad, Piyarat Govitrapong
Alzheimer's disease (AD) is a chronic, progressive and prevalent neurodegenerative disease characterized by the loss of higher cognitive functions and an associated loss of memory. The thus far "incurable" stigma for AD prevails because of variations in the success rates of different treatment protocols in animal and human studies. Among the classical hypotheses explaining AD pathogenesis, the amyloid hypothesis is currently being targeted for drug development. The underlying concept is to prevent the formation of these neurotoxic peptides which play a central role in AD pathology and trigger a multispectral cascade of neurodegenerative processes post-aggregation...
March 13, 2017: Current Neuropharmacology
https://www.readbyqxmd.com/read/28282993/thermosensitive-porphyrin-incorporated-hydrogel-with-four-arm-peg-pcl-copolymer-ii-doxorubicin-loaded-hydrogel-as-a-dual-fluorescent-drug-delivery-system-for-simultaneous-imaging-tracking-in-vivo
#8
Xia Dong, Hongli Chen, Jingwen Qin, Chang Wei, Jie Liang, Tianjun Liu, Deling Kong, Feng Lv
Visualization of a drug delivery system could reveal the pharmacokinetic properties, which is essential for the design of a novel drug delivery system. In vivo optical imaging offers an advanced tool to monitor the drug release process and the therapeutic effect by the combination of fluorescence imaging and bioluminescence imaging. Multispectral fluorescence imaging can separate the drug and the carrier without interference. Herein, a dual fluorescent anti-tumor drug delivery system was monitored with the doxorubicin-loaded hydrogel to further explore the application of the porphyrin-incorporated hydrogel with four-arm PEG-PCL copolymer as a drug carrier, based on the beneficial fluorescence and good biocompatibility of the porphyrin incorporated hydrogel...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28274351/objective-assessment-of-acne
#9
Markus Becker, Thomas Wild, Christos C Zouboulis
A precise and reliable assessment of acne severity is unarguably the most essential clinical method when it comes to monitoring and choosing optimal treatment in the daily practice. Since the early 1960s, different severity assessment systems have been described in the literature. The two commonly used concepts are global gradings and lesion counting. Both systems have been controversially discussed as to which is more reliable and providing an objective outcome measurement tool; however, both have some subjectivity involved...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28270991/joint-alignment-of-multispectral-images-via-semidefinite-programming
#10
Yuanjie Zheng, Yu Wang, Wanzhen Jiao, Sujuan Hou, Yanju Ren, Maoling Qin, Dewen Hou, Chao Luo, Hong Wang, James Gee, Bojun Zhao
In this paper, we introduce a novel feature-point-matching based framework for achieving an optimized joint-alignment of sequential images from multispectral imaging (MSI). It solves a low-rank and semidefinite matrix that stores all pairwise-image feature-mappings by minimizing the total amount of point-to-point matching cost via a convex optimization of a semidefinite programming formulation. This unique strategy takes a complete consideration of the information aggregated by all point-matching costs and enables the entire set of pairwise-image feature-mappings to be solved simultaneously and near-optimally...
February 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28269155/automatic-classification-of-cancer-cells-in-multispectral-microscopic-images-of-lymph-node-samples
#11
Gali Zimmerman-Moreno, Irina Marin, Moshe Lindner, Iris Barshack, Yuval Garini, Eli Konen, Arnaldo Mayer
Histopathological analysis is crucial for the diagnosis of a large number of cancer types. A lot of progress has been made in the development of molecular based assays, but many of the cases still require the careful analysis of the stained tissue under a bright-field microscope and its analysis. This procedure is costly and time-consuming. We present a novel method for classification of cancer cells in lymph node images. It is based on the measurement of the spectral image of hematoxylin and eosin stained sample under the microscope and the analysis of the acquired data using state of the art machine learning techniques...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28263836/optical-barcoding-of-plga-for-multispectral-analysis-of-nanoparticle-fate-in-vivo
#12
David X Medina, Kyle T Householder, Ricki Ceton, Tina Kovalik, John M Heffernan, Rohini V Shankar, Robert P Bowser, Robert J Wechsler-Reya, Rachael W Sirianni
Understanding of the mechanisms by which systemically administered nanoparticles achieve delivery across biological barriers remains incomplete, due in part to the challenge of tracking nanoparticle fate in the body. Here, we develop a new approach for "barcoding" nanoparticles (NPs) composed of poly(lactic-co-glycolic acid) (PLGA) with bright, spectrally defined quantum dots (QDs) to enable direct, fluorescent detection of NP fate with subcellular resolution. We show that QD labeling does not affect major biophysical properties of NPs or their interaction with cells and tissues...
March 2, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28261847/improved-field-mapping-and-artifact-correction-in-multispectral-imaging
#13
Brady Quist, Xinwei Shi, Hans Weber, Brian A Hargreaves
PURPOSE: To develop a method for improved B0 field-map estimation, deblurring, and image combination for multispectral imaging near metal. METHODS: A goodness-of-fit field-map estimation technique is proposed that uses only the multispectral imaging (MSI) data to estimate the field map. Using the improved field map, a novel deblurring technique is proposed that also employs a new image combination scheme to reduce the effects of noise and other residual MSI artifacts...
March 5, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28259766/multispectral-uv-imaging-for-determination-of-the-tablet-coating-thickness
#14
Anna Novikova, Jens M Carstensen, J Axel Zeitler, Thomas Rades, Claudia S Leopold
The applicability of off-line multispectral ultraviolet (UV) imaging in combination with multivariate data analysis was investigated to determine the coating thickness and its distribution on the tablet surface during lab scale coating. The UV imaging results were compared with the weight gain measured for each individual tablet and the corresponding coating thickness and its distribution measured by terahertz pulsed imaging (TPI). Three different tablet formulations were investigated, two of which contained UV active tablet cores...
March 1, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28241623/hybrid-imprinting-process-to-fabricate-a-multi-layer-compound-eye-for-multispectral-imaging
#15
Jianwei Chen, Hiu Hung Lee, Dongping Wang, Si Di, Shih-Chi Chen
We present a high-precision hybrid imprinting method to fabricate multi-layer micro-optical structures on nonplanar substrates using a custom-built vacuum imprinting system; with the application of kinematic couplings that align the flexible stamps in all six degrees of freedom, a cross-layer pattern registration precision of 400 nm has been achieved on nonplanar substrates. To demonstrate the precision and feasibility of the new process and instrument, we have designed and fabricated a multi-layer artificial compound eye (ACE) for multispectral imaging...
February 20, 2017: Optics Express
https://www.readbyqxmd.com/read/28240872/annexin-v-conjugated-mixed-micelles-as-a-potential-drug-delivery-system-for-targeted-thrombolysis
#16
Yang Pan, Xiaoting Ren, Shuang Wang, Xin Li, Xianglin Luo, Zongning Yin
To alleviate the hemorrhagic side effect of thrombolysis therapy, a thrombus targeted drug delivery system based on the specific affinity of Annexin V to phosphatidylserine exposed on the membrane surface of activated platelet was developed. The amphiphilic and biodegradable biomaterial, polycaprolactone-block-poly(2-(dimethylamino)ethyl methacrylate)-block-poly(2-hydroxyethyl methacrylate) (PCL-b-PDMAEMA-b-PHEMA (PCDH)) triblock polymer, was synthesized via ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) to use as the nanocarriers of thrombolytic drug...
March 13, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28237924/bayesian-estimation-of-intrinsic-tissue-oxygenation-and-perfusion-from-rgb-images
#17
Geoffrey Jones, Neil Clancy, Yusuf Helo, Simon Arridge, Dan Elson, Danail Stoyanov
Multispectral imaging (MSI) can potentially assist the intra-operative assessment of tissue structure, function and viability, by providing information about oxygenation. In this paper, we present a novel technique for recovering intrinsic MSI measurements from endoscopic RGB images without custom hardware adaptations. The advantage of this approach is that it requires no modification to existing surgical and diagnostic endoscopic imaging systems. Our method uses a radiometric colour calibration of the endoscopic camera's sensor in conjunction with a Bayesian framework to recover a per-pixel measurement of the total blood volume (THb) and oxygen saturation (SO2) in the observed tissue...
February 20, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28227384/automatic-classification-of-cancer-cells-in-multispectral-microscopic-images-of-lymph-node-samples
#18
Gali Zimmerman-Moreno, Irina Marin, Moshe Lindner, Iris Barshack, Yuval Garini, Eli Konen, Arnaldo Mayer, Gali Zimmerman-Moreno, Irina Marin, Moshe Lindner, Iris Barshack, Yuval Garini, Eli Konen, Arnaldo Mayer, Moshe Lindner, Yuval Garini, Gali Zimmerman-Moreno, Arnaldo Mayer, Eli Konen, Iris Barshack, Irina Marin
Histopathological analysis is crucial for the diagnosis of a large number of cancer types. A lot of progress has been made in the development of molecular based assays, but many of the cases still require the careful analysis of the stained tissue under a bright-field microscope and its analysis. This procedure is costly and time-consuming. We present a novel method for classification of cancer cells in lymph node images. It is based on the measurement of the spectral image of hematoxylin and eosin stained sample under the microscope and the analysis of the acquired data using state of the art machine learning techniques...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28194960/method-for-noninvasive-analysis-of-proteins-and-small-molecules-from-ancient-objects
#19
Marcello Manfredi, Elettra Barberis, Fabio Gosetti, Eleonora Conte, Giorgio Gatti, Clara Mattu, Elisa Robotti, Gleb Zilberstein, Igor Koman, Svetlana Zilberstein, Emilio Marengo, Pier Giorgio Righetti
Proteins and small molecules from ancient objects and cultural heritage can provide key information and contribute to study the context of objects and artists. However, all present-day protocols and strategies for the analysis of ancient samples are often invasive and require microsampling. Here, we present a new method for the noninvasive analysis of proteins and small molecules: the technique uses a special ethyl-vinyl acetate film functionalized with strong cation/anion exchange and C8 resins, for interacting with both proteins and small molecules present on the surface of the objects, followed by LC-MS/MS analysis...
March 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28191450/remotely-triggered-nano-theranostics-for-cancer-applications
#20
Alexandra Sneider, Derek VanDyke, Shailee Paliwal, Prakash Rai
Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response, and, if required, initiate secondary treatments. Recent in vivo experiments demonstrate the promise of using theranostics in the clinic. In this paper, we review the use of remotely triggered theranostic nanoparticles for cancer applications, focusing heavily on advances in the past five years. Remote triggering mechanisms covered include photodynamic, photothermal, phototriggered chemotherapeutic release, ultrasound, electro-thermal, magneto-thermal, X-ray, and radiofrequency therapies...
2017: Nanotheranostics
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