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https://www.readbyqxmd.com/read/29772692/insurance-coverage-policies-for-pharmacogenomic-and-multi-gene-testing-for-cancer
#1
Christine Y Lu, Stephanie Loomer, Rachel Ceccarelli, Kathleen M Mazor, James Sabin, Ellen Wright Clayton, Geoffrey S Ginsburg, Ann Chen Wu
Insurance coverage policies are a major determinant of patient access to genomic tests. The objective of this study was to examine differences in coverage policies for guideline-recommended pharmacogenomic tests that inform cancer treatment. We analyzed coverage policies from eight Medicare contractors and 10 private payers for 23 biomarkers (e.g., HER2 and EGFR ) and multi-gene tests. We extracted policy coverage and criteria, prior authorization requirements, and an evidence basis for coverage. We reviewed professional society guidelines and their recommendations for use of pharmacogenomic tests...
May 16, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29760380/a-new-inhibitor-of-glucose-6-phosphate-dehydrogenase-blocks-pentose-phosphate-pathway-and-suppresses-malignant-proliferation-and-metastasis-in-vivo
#2
Luigi Mele, Francesca Paino, Federica Papaccio, Tarik Regad, David Boocock, Paola Stiuso, Angela Lombardi, Davide Liccardo, Gabriella Aquino, Antonio Barbieri, Claudio Arra, Clare Coveney, Marcella La Noce, Gianpaolo Papaccio, Michele Caraglia, Virginia Tirino, Vincenzo Desiderio
Pentose phosphate pathway (PPP) is a major glucose metabolism pathway, which has a fundamental role in cancer growth and metastasis. Even though PPP blockade has been pointed out as a very promising strategy against cancer, effective anti-PPP agents are not still available in the clinical setting. Here we demonstrate that the natural molecule polydatin inhibits glucose-6-phosphate dehydrogenase (G6PD), the key enzyme of PPP. Polydatin blocks G6PD causing accumulation of reactive oxygen species and strong increase of endoplasmic reticulum stress...
May 14, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29753088/prognostic-significance-of-g6pd-expression-and-localization-in-lung-adenocarcinoma
#3
Ryo Nagashio, Shota Oikawa, Kengo Yanagita, Daisuke Hagiuda, Yuki Kuchitsu, Satoshi Igawa, Katsuhiko Naoki, Yukitoshi Satoh, Masaaki Ichinoe, Yoshiki Murakumo, Makoto Saegusa, Yuichi Sato
Abnormal expressions of extracellular matrix (ECM) proteins are correlated with increased tumor progression, an advanced histologic grade, and metastasis. LCN1 cells derived from a pulmonary large cell neuroendocrine carcinoma were grown to form an Aegagropila-shaped conglomeration on a suspension culture dish (LCN1-sus). In contrast, LCN1 cells cultured in a type I collagen dish were adherent and tended to grow as spindle-shaped individual cells (LCN1-co). In this study, aiming at the discovery of predictive markers for tumor invasion, we performed protein profiling between LCN1-sus and LCN1-co cells using two-dimensional gel electrophoresis...
May 9, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29748501/proteomic-investigation-to-identify-anticancer-targets-of-nemopilema-nomurai-jellyfish-venom-in-human-hepatocarcinoma-hepg2-cells
#4
Indu Choudhary, Hyunkyoung Lee, Min Jung Pyo, Yunwi Heo, Jinho Chae, Seung Shic Yum, Changkeun Kang, Euikyung Kim
Nemopilema nomurai is a giant jellyfish that blooms in East Asian seas. Recently, N. nomurai venom (NnV) was characterized from a toxicological and pharmacological point of view. A mild dose of NnV inhibits the growth of various kinds of cancer cells, mainly hepatic cancer cells. The present study aims to identify the potential therapeutic targets and mechanism of NnV in the growth inhibition of cancer cells. Human hepatocellular carcinoma (HepG2) cells were treated with NnV, and its proteome was analyzed using two-dimensional gel electrophoresis, followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI/TOF/MS)...
May 10, 2018: Toxins
https://www.readbyqxmd.com/read/29739104/prevalence-of-glucose-6-phosphate-dehydrogenase-deficiency-in-sichuan-china
#5
Jing Zhang, Yali Cui, Xia Wang, Yingying Li, Dongmei Jiang, Wei Dai, Yongmei Jiang
BACKGROUND: Our goals were to screen newborns and characterize the occurrence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in southwestern China. Meanwhile, we would like to analyze the factors that might affect the results of neonatal dried blood spots for glucose-6-phosphate dehydrogenase screening test, to improve the clinical quality control level, effectively reduce the external factors in the process of detection. METHODS: This study involved an evaluation of G6PD data for 20,644 newborns from a universal newborn screening program...
March 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29738562/validation-of-the-quantitative-point-of-care-carestart-biosensor-for-assessment-of-g6pd-activity-in-venous-blood
#6
Germana Bancone, Gornpan Gornsawun, Cindy S Chu, Pen Porn, Sampa Pal, Pooja Bansil, Gonzalo J Domingo, Francois Nosten
INTRODUCTION: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in the human population affecting an estimated 8% of the world population, especially those living in areas of past and present malaria endemicity. Decreased G6PD enzymatic activity is associated with drug-induced hemolysis and increased risk of severe neonatal hyperbilirubinemia leading to brain damage. The G6PD gene is on the X chromosome therefore mutations cause enzymatic deficiency in hemizygote males and homozygote females while the majority of heterozygous females have an intermediate activity (between 30-80% of normal) with a large distribution into the range of deficiency and normality...
2018: PloS One
https://www.readbyqxmd.com/read/29720963/deoxyribonucleotide-triphosphate-metabolism-in-cancer-and-metabolic-disease
#7
REVIEW
Raquel Buj, Katherine M Aird
The maintenance of a healthy deoxyribonucleotide triphosphate (dNTP) pool is critical for the proper replication and repair of both nuclear and mitochondrial DNA. Temporal, spatial, and ratio imbalances of the four dNTPs have been shown to have a mutagenic and cytotoxic effect. It is, therefore, essential for cell homeostasis to maintain the balance between the processes of dNTP biosynthesis and degradation. Multiple oncogenic signaling pathways, such as c-Myc, p53, and mTORC1 feed into dNTP metabolism, and there is a clear role for dNTP imbalances in cancer initiation and progression...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29713062/thymidine-catabolism-promotes-nadph-oxidase-derived-reactive-oxygen-species-ros-signalling-in-kb-and-yumoto-cells
#8
Sho Tabata, Masatatsu Yamamoto, Hisatsugu Goto, Akiyoshi Hirayama, Maki Ohishi, Takuya Kuramoto, Atsushi Mitsuhashi, Ryuji Ikeda, Misako Haraguchi, Kohichi Kawahara, Yoshinari Shinsato, Kentaro Minami, Atsuro Saijo, Yuko Toyoda, Masaki Hanibuchi, Yasuhiko Nishioka, Saburo Sone, Hiroyasu Esumi, Masaru Tomita, Tomoyoshi Soga, Tatsuhiko Furukawa, Shin-Ichi Akiyama
Thymidine phosphorylase (TP) is a rate-limiting enzyme in the thymidine catabolic pathway. TP is identical to platelet-derived endothelial cell growth factor and contributes to tumour angiogenesis. TP induces the generation of reactive oxygen species (ROS) and enhances the expression of oxidative stress-responsive genes, such as interleukin (IL)-8. However, the mechanism underlying ROS induction by TP remains unclear. In the present study, we demonstrated that TP promotes NADPH oxidase-derived ROS signalling in cancer cells...
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29702993/stard-rapid-screening-for-the-6-most-common-g6pd-gene-mutations-in-the-chinese-population-using-the-amplification-refractory-mutation-system-combined-with-melting-curve-analysis
#9
Zuqian Fan, Xunjin Weng, Guosheng Huang, Zhijian Pan, Zhao Long, Qiongying Fan, Weijun Tang, Lin Fang, Ju Long, Tian Hu, Yongxia Huang, Lei Sun
Dot-blot hybridization and high-resolution melting curve methods are used to detect G6PD gene mutations; however, the performance and throughput limitations of these methods hinder their use for screening large populations. For simple screening, we developed a novel approach called "Amplification Refractory Mutation System combined with Melting Curve Analysis (ARMS-MC)," which enables rapid and batch-based detection of the 6 most common G6PD mutations.In this method, we established 4 PCR reaction systems that can be used to detect the 6 most common G6PD mutations (c...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29702405/regulation-of-ampk-related-glycolipid-metabolism-imbalances-redox-homeostasis-and-inhibits-anchorage-independent-growth-in-human-breast-cancer-cells
#10
Lin Yang, Zihao He, Jingyue Yao, Renxiang Tan, Yejin Zhu, Zhiyu Li, Qinglong Guo, Libin Wei
Breast cancer is one of the most lethal tumors in the world, among which 15% are triple-negative breast cancers (TNBCs) with higher metastasis and lower survival rate. Anoikis resistance is a key process during tumor metastasis, which is usually accompanied with metabolism reprogram. In this study, we established an anchorage independent growth model for MDA-MB-231 cells and investigated the changes in metabolism and redox homeostasis. Results showed that during detached-growth, MDA-MB-231 cells tend to generate ATP through fatty acid oxidation (FAO), instead of glycolysis...
April 18, 2018: Redox Biology
https://www.readbyqxmd.com/read/29699064/inverse-association-between-glucose%C3%A2-6%C3%A2-phosphate-dehydrogenase-deficiency-and-hepatocellular-carcinoma
#11
Maria Pina Dore, Gianpaolo Vidili, Giuseppina Marras, Silas Assy, Giovanni Mario Pes
Background: Studies in experimental models and humans suggest that glucose‒6‒phosphate dehydrogenase (G6PD) deficiency, an inherited condition, may be inversely related to hepatocellular carcinoma (HCC). We tested this hypothesis in a large cohort of Sardinian patients. Methods: A case-control study was performed using data from 11,143 records of patients who underwent upper endoscopy between 2002 and 2017. Gender, age, G6PD status and information regarding the presence of HCC, were recorded. Cases (HCC positive) and controls (HCC negative) were compared for the presence of G6PD deficiency adjusting for major HCC risk factors using logistic regression...
April 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29690878/efficacy-and-safety-of-methylene-blue-in-the-treatment-of-malaria-a-systematic-review
#12
G Lu, M Nagbanshi, N Goldau, M Mendes Jorge, P Meissner, A Jahn, F P Mockenhaupt, O Müller
BACKGROUND: Methylene blue (MB) was the first synthetic antimalarial to be discovered and was used during the late 19th and early 20th centuries against all types of malaria. MB has been shown to be effective in inhibiting Plasmodium falciparum in culture, in the mouse model and in rhesus monkeys. MB was also shown to have a potent ex vivo activity against drug-resistant isolates of P. falciparum and P. vivax. In preclinical studies, MB acted synergistically with artemisinin derivates and demonstrated a strong effect on gametocyte reduction in P...
April 25, 2018: BMC Medicine
https://www.readbyqxmd.com/read/29686715/knowledge-level-and-determinants-of-neonatal-jaundice-a-cross-sectional-study-in-the-effutu-municipality-of-ghana
#13
Prince Adoba, Richard K D Ephraim, Kate Adomakowaah Kontor, Joseph-Josiah Bentsil, Patrick Adu, Maxwell Anderson, Samuel Asamoah Sakyi, Paul Nsiah
Background: Neonatal jaundice (NNJ) is a major cause of hospital admission during the neonatal period and is associated with significant mortality. This case-control study with cross-sectional design sought to identify the possible factors associated with neonatal jaundice and assess maternal knowledge level of this condition. Methods: One hundred and fifty (150) neonates comprising 100 with clinically evident jaundice and 50 without jaundice were conveniently recruited from the Trauma and Specialist Hospital in the Effutu Municipality...
2018: International Journal of Pediatrics
https://www.readbyqxmd.com/read/29681509/regional-differences-in-brain-glucose-metabolism-determined-by-imaging-mass-spectrometry
#14
André Kleinridders, Heather A Ferris, Michelle L Reyzer, Michaela Rath, Marion Soto, M Lisa Manier, Jeffrey Spraggins, Zhihong Yang, Robert C Stanton, Richard M Caprioli, C Ronald Kahn
OBJECTIVE: Glucose is the major energy substrate of the brain and crucial for normal brain function. In diabetes, the brain is subject to episodes of hypo- and hyperglycemia resulting in acute outcomes ranging from confusion to seizures, while chronic metabolic dysregulation puts patients at increased risk for depression and Alzheimer's disease. In the present study, we aimed to determine how glucose is metabolized in different regions of the brain using imaging mass spectrometry (IMS)...
April 6, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29677199/implications-of-current-therapeutic-restrictions-for-primaquine-and-tafenoquine-in-the-radical-cure-of-vivax-malaria
#15
James Watson, Walter R J Taylor, Germana Bancone, Cindy S Chu, Podjanee Jittamala, Nicholas J White
BACKGROUND: The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with <30% and <70% of normal G6PD activity are not given standard regimens of primaquine and tafenoquine, respectively. Both drugs are currently considered contraindicated in pregnant and lactating women. METHODS: Quantitative G6PD enzyme activity data from 5198 individuals were used to estimate the proportions of heterozygous females who would be ineligible for treatment at the 30% and 70% activity thresholds, and the relationship with the severity of the deficiency...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29672516/use-of-primaquine-and-glucose-6-phosphate-dehydrogenase-deficiency-testing-divergent-policies-and-practices-in-malaria-endemic-countries
#16
REVIEW
Judith Recht, Elizabeth A Ashley, Nicholas J White
Primaquine is the only available antimalarial drug that kills dormant liver stages of Plasmodium vivax and Plasmodium ovale malarias and therefore prevents their relapse ('radical cure'). It is also the only generally available antimalarial that rapidly sterilises mature P. falciparum gametocytes. Radical cure requires extended courses of primaquine (usually 14 days; total dose 3.5-7 mg/kg), whereas transmissibility reduction in falciparum malaria requires a single dose (formerly 0.75 mg/kg, now a single low dose [SLD] of 0...
April 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29653099/herbacetin-a-flaxseed-flavonoid-ameliorates-high-percent-dietary-fat-induced-insulin-resistance-and-lipid-accumulation-through-the-regulation-of-hepatic-lipid-metabolizing-and-lipid-regulating-enzymes
#17
Chinnadurai Veeramani, Mohammed A Alsaif, Khalid S Al-Numair
Healthy plants and their constituents have been considered as a safe remedy for the treatment of obesity and obesity associated diseases. Herbacetin is a dietary flavonoid that has been explored for many pharmacological activities; but, the anti-hyperglycaemic and anti-hyperlipidemic properties of herbacetin have not yet been explored. The present study was performed to evaluate the ameliorative effect of herbacetin on high-fat diet-induced hyperglycaemia and hyperlipidemia in 57BL/6 J mice. Obesity associated insulin resistance was induced by continuously feeding the mice with high-fat diet for 10 weeks...
April 10, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29626298/l-cysteine-in-vitro-can-restore-cellular-glutathione-and-inhibits-the-expression-of-cell-adhesion-molecules-in-g6pd-deficient-monocytes
#18
Rajesh Parsanathan, Sushil K Jain
L-Cysteine is a precursor of glutathione (GSH), a potent physiological antioxidant. Excess glucose-6-phosphate dehydrogenase (G6PD) deficiency in African Americans and low levels of L-cysteine diet in Hispanics can contributes to GSH deficiency and oxidative stress. Oxidative stress and monocyte adhesion was considered to be an initial event in the progression of vascular dysfunction and atherosclerosis. However, no previous study has investigated the contribution of GSH/G6PD deficiency to the expression of monocyte adhesion molecules...
April 6, 2018: Amino Acids
https://www.readbyqxmd.com/read/29624775/highly-efficient-ssodn-mediated-homology-directed-repair-of-dsbs-generated-by-cripsr-cas9-in-human-3pn-zygotes
#19
Lichun Tang, Yanting Zeng, Xuewei Zhou, Hongzi Du, Chuang Li, Jianqiao Liu, Pumin Zhang
Ma et al. published data in Nature Journal using human zygotes that showed that double-strand breaks (DSBs) generated by CRISPR/Cas9 could be repaired by homology-directed repair (HDR) using the wild-type allele as a template, by inter-homologue recombination (Ma et al., 2017). This result received great attention from the scientific community, however, in a recent publication, researchers have raised some concerns about Ma's interpretation of their results (Egli et al., 2017). Our previous work showed that ssODN-mediated HDR could repair 75% of DSBs generated by CRISPR/Cas9 at G6PD mutant alleles (Tang et al...
April 6, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29614629/genetic-modifiers-of-severity-in-sickle-cell-disease
#20
Alicia K Chang, Carly C Ginter Summarell, Parendi T Birdie, Vivien A Sheehan
Sickle cell disease (SCD) is one of the most common single disease disorders world-wide. It is remarkable for its clinical heterogeneity, even among individuals with identical genotypes. Some individuals experience morbidity and mortality in early childhood, while others have a relatively mild course, and normal or near normal life expectancy. Many clinical complications are associated with SCD; most notably frequent pain episodes, stroke, acute chest syndrome, avascular necrosis, nephropathy, retinopathy and pulmonary hypertension...
2018: Clinical Hemorheology and Microcirculation
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