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https://www.readbyqxmd.com/read/28445195/protective-effect-of-botulinum-toxin-type-a-against-atopic-dermatitis-like-skin-lesions-in-nc-nga-mice
#1
Sang Bum Han, Hyeree Kim, Sang Hyun Cho, Jin Ho Chung, Hei Sung Kim
BACKGROUND: Botulinum neurotoxin (BTX) A possesses various biological activities, including anti-inflammatory and antipruritic actions. Human and animal studies have shown that BTX is effective in treating histamine-induced itch, lichen simplex chronicus, psoriasis, rosacea, allergic rhinitis, and scar prevention. However, its effect on atopic dermatitis (AD) has not been studied yet. OBJECTIVE: To examine the effect of BTX on AD using a mouse model. The primary outcome was skin thickness and transepidermal water loss (TEWL), and the secondary outcome was the alteration in skin severity scores, histological, and laboratory test results...
April 24, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28440002/differential-effect-of-incobotulinumtoxin-a-on-pain-neurogenic-flare-and-hyperalgesia-in-human-surrogate-models-of-neurogenic-pain
#2
S A Diener, M Breimhorst, Th Vogt, H H Krämer, P D Drummond, C Geber, F Birklein
BACKGROUND: The effectiveness of Botulinum-neurotoxin A (BoNT/A) to treat pain in human pain models is very divergent. This study was conducted to clarify if the pain models or the route of BoNT/A application might be responsible for these divergent findings. METHODS: Sixteen healthy subjects (8 males, mean age 27 ± 5 years) were included in a first set of experiments consisting of three visits: (1) Visit: Quantitative sensory testing (QST) was performed before and after intradermal capsaicin injection (CAPS, 15 μg) on one thigh and electrical current stimulation (ES, 1 Hz) on the contralateral thigh...
April 25, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28422819/gnaq-tt-695-694-gc-polymorphism-is-associated-with-increased-gq-expression-vascular-reactivity-and-myocardial-injury-after-coronary-artery-bypass-surgery
#3
Ulrich H Frey, Stefanie Klenke, Anna Mitchell, Tim Knüfermann, Heinz Jakob, Matthias Thielmann, Winfried Siffert, Jürgen Peters
BACKGROUND: Angiotensin II receptor type 1-mediated activation of the α-subunit of the heterotrimeric Gq protein evokes increased vasoconstriction and may promote hypertrophy-induced myocardial damage. The authors recently identified a TT(-695/-694)GC polymorphism in the human Gq promoter, the GC allele being associated with an increased prevalence of cardiac hypertrophy. In this article, the authors tested whether the TT(-695/-694)GC polymorphism is associated with differences in (1) myocardial Gq protein expression, (2) vascular reactivity, and (3) myocardial damage after coronary artery bypass grafting...
April 19, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28419121/the-magnitude-of-ivacaftor-effects-on-fluid-secretion-via-r117h-cftr-channels-human-in-vivo-measurements
#4
Jessica E Char, Colleen Dunn, Zoe Davies, Carlos Milla, Richard B Moss, Jeffrey J Wine
We optically measured effects of orally available ivacaftor (Kalydeco®) on sweat rates of identified glands in 3 R117H subjects, each having a unique set of additional mutations, and compared them with 5 healthy control subjects tested contemporaneously. We injected β-adrenergic agonists intradermally to stimulate CFTR-dependent 'C-sweat' and methacholine to stimulate 'M-sweat', which persists in CF subjects. We focused on an R117H-7T/F508del subject who produced quantifiable C-sweat off ivacaftor and was available for 1 blinded, 3 off ivacaftor, and 3 on ivacaftor tests, allowing us to estimate in vivo fold-increase in sweat rates produced by ivacaftor's effect on the open probability (PO) of R117H-CFTR...
2017: PloS One
https://www.readbyqxmd.com/read/28418213/pain-thresholds-supra-threshold-pain-and-lidocaine-sensitivity-in-patients-with-erythromelalgia-including-the-i848tmutation-in-nav-1-7
#5
T Helås, D Sagafos, I P Kleggetveit, H Quiding, B Jönsson, M Segerdahl, Z Zhang, H Salter, M Schmelz, E Jørum
OBJECTIVES: Nociceptive thresholds and supra-threshold pain ratings as well as their reduction upon local injection with lidocaine were compared between healthy subjects and patients with erythromelalgia (EM). METHODS: Lidocaine (0.25, 0.50, 1.0 or 10 mg/mL) or placebo (saline) was injected intradermally in non-painful areas of the lower arm, in a randomized, double-blind manner, to test the effect on dynamic and static mechanical sensitivity, mechanical pain sensitivity, thermal thresholds and supra-threshold heat pain sensitivity...
April 18, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28410699/anaphylaxis-to-rifampicin-and-pyrazinamide-in-a-child-with-tuberculous-meningitis-a-case-report
#6
Gulnaz Nadri, Sunil Taneja, Varinder Singh, Purvi Mittal
Rifampicin (RFP) and pyrazinamide (PZA) are the primary anti-tubercular drugs with a considerably safe profile. However, none of the drugs are without adverse reactions. They both can lead to a variety of adverse effects including life-threatening anaphylaxis. We report an interesting and possibly the first case of concurrent hypersensitivity to two primary anti-tubercular treatment (ATT) drugs. Hypersensitivity to RFP and PZA was confirmed in this patient by drug provocation and intradermal skin testing. He improved on alternative ATT regime withdrawing RFP and PZA...
April 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28382604/non-immediate-cutaneous-reactions-to-beta-lactams-approach-to-diagnosis
#7
REVIEW
Antonino Romano, Rocco Luigi Valluzzi, Cristiano Caruso, Michela Maggioletti, Francesco Gaeta
Non-immediate cutaneous reactions (i.e., occurring at least 1 h after the initial drug administration), particularly maculopapular exanthemas and urticarial eruptions, are common during beta-lactam treatments. A T cell-mediated pathogenic mechanism has been demonstrated in some cutaneous reactions, such as maculopapular exanthema, fixed drug eruption, acute generalized exanthematous pustulosis, and drug-induced hypersensitivity syndrome. In the diagnostic work-up, patch testing is useful, together with delayed-reading intradermal testing...
April 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28378949/de-labelling-self-reported-penicillin-allergy-within-the-emergency-department-through-the-use-of-skin-tests-and-oral-drug-provocation-testing
#8
Joseph Marwood, Gonzalo Aguirrebarrena, Stephen Kerr, Susan A Welch, Janet Rimmer
OBJECTIVE: Self-reported penicillin allergy is common among patients attending the ED, but is a poor predictor of true immunoglobulin E-mediated hypersensitivity to penicillin. We hypothesise that with a combination of skin testing and drug provocation testing, selected patients can be safely de-labelled of their allergy. METHODS: This prospective study enrolled a sample of patients presenting to an urban academic ED between 2011 and 2016 with a self-reported allergy to penicillin...
April 5, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/28372590/proteomic-analysis-of-protein-purified-derivative-of-mycobacterium-bovis
#9
Sante Roperto, Mariaconcetta Varano, Valeria Russo, Roberta Lucà, Monica Cagiola, Marco Gaspari, Dora Maria Ceccarelli, Giovanni Cuda, Franco Roperto
BACKGROUND: Tuberculin skin test based on in vivo intradermal inoculation of purified protein derivative from Mycobacterium bovis (bPPD) is the diagnostic test for the control and surveillance of bovine tuberculosis (bTB). METHODS: Proteomic analysis was performed on different bPPD preparations from M. bovis, strain AN5. Proteins were precipitated from bPPD solutions by TCA precipitation. The proteome of bPPD preparations was investigated by bottom-up proteomics, which consisted in protein digestion and nano-LC-MS/MS analysis...
April 3, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28368217/long-acting-insulin-allergy-in-a-diabetic-child
#10
Carla Mastrorilli, Laura Rizzuti, Antonina Marta Cangelosi, Brunella Iovane, Giovanni Chiari, Carlo Caffarelli
Insulin allergy has been uncommon since the introduction of human recombinant insulin preparations; the prevalence is 2.4%. Insulin injection could elicit immediate reactions, which are usually induced by an IgE-mediated mechanism, within the first hour after drug administration. In the present study, we describe the case of a child who experienced immediate urticaria after long-acting insulin injection. A 9-year-old girl affected by type I diabetes mellitus referred a history of three episodes of urticaria 30 min after insulin subcutaneous injection...
April 1, 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28365253/semiconductor-diode-laser-device-adjuvanting-intradermal-vaccine
#11
Yoshifumi Kimizuka, John J Callahan, Zilong Huang, Kaitlyn Morse, Wataru Katagiri, Ayako Shigeta, Roderick Bronson, Shu Takeuchi, Yusuke Shimaoka, Megan P K Chan, Yang Zeng, Binghao Li, Huabiao Chen, Rhea Y Y Tan, Conor Dwyer, Tyler Mulley, Pierre Leblanc, Calum Goudie, Jeffrey Gelfand, Kosuke Tsukada, Timothy Brauns, Mark C Poznansky, David Bean, Satoshi Kashiwagi
A brief exposure of skin to a low-power, non-tissue damaging laser light has been demonstrated to augment immune responses to intradermal vaccination. Both preclinical and clinical studies show that this approach is simple, effective, safe and well tolerated compared to standard chemical or biological adjuvants. Until now, these laser exposures have been performed using a diode-pumped solid-state laser (DPSSL) devices, which are expensive and require labor-intensive maintenance and special training. Development of an inexpensive, easy-to-use and small device would form an important step in translating this technology toward clinical application...
April 25, 2017: Vaccine
https://www.readbyqxmd.com/read/28347519/meta-analyses-of-the-sensitivity-and-specificity-of-ante-mortem-and-post-mortem-diagnostic-tests-for-bovine-tuberculosis-in-the-uk-and-ireland
#12
Javier Nuñez-Garcia, Sara H Downs, Jessica E Parry, Darrell A Abernethy, Jennifer M Broughan, Angus R Cameron, Alasdair J Cook, Ricardo de la Rua-Domenech, Anthony V Goodchild, Jane Gunn, Simon J More, Shelley Rhodes, Simon Rolfe, Michael Sharp, Paul A Upton, H Martin Vordermeier, Eamon Watson, Michael Welsh, Adam O Whelan, John A Woolliams, Richard S Clifton-Hadley, Matthias Greiner
Bovine Tuberculosis (bTB) in cattle is a global health problem and eradication of the disease requires accurate estimates of diagnostic test performance to optimize their efficiency. The objective of this study was, through statistical meta-analyses, to obtain estimates of sensitivity (Se) and specificity (Sp), for 14 different ante-mortem and post-mortem diagnostic tests for bTB in cattle. Using data from a systematic review of the scientific literature (published 1934-2009) diagnostic Se and Sp were estimated using Bayesian logistic regression models adjusting for confounding factors...
March 6, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28342246/hypohidrosis-and-metal-allergy-trigger-factors-for-unilateral-lichen-planus
#13
Takeshi Fukumoto, Shinji Tsuchiyama, Atsushi Fukunaga, Chikako Nishigori
Unilateral lichen planus (LP) is a rare clinical variant of LP. The etiology of unilateral LP has not been clarified, although various causes have been reported because of the characteristic distribution. We focused on the contribution of metal allergy and sweating in the development of unilateral LP in this case. To confirm the presence of metal allergy, patch tests with metal allergens were performed. To investigate the cause of the unilateral distribution in unilateral LP, the function of sweating and sweat leaking in the dermis was assessed by a thermoregulatory sweat test and immunohistochemical staining of dermcidin...
March 24, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28340570/the-therapeutic-hiv-env-c5-gp41-vaccine-candidate-vacc-c5-induces-specific-t-cell-regulation-in-a-phase-i-ii-clinical-study
#14
Kristin Brekke, Maja Sommerfelt, Mats Ökvist, Anne Margarita Dyrhol-Riise, Dag Kvale
BACKGROUND: Levels of non-neutralising antibodies (AB) to the C5 domain of HIV Env gp120 are inversely related to progression of HIV infection. In this phase I/II clinical study we investigated safety of Vacc-C5, a peptide-based therapeutic vaccine candidate corresponding to C5/gp41(732-744) as well as the effects on pre-existing AB levels to C5/gp41(732-744), immune activation and T cell responses including exploratory assessments of Vacc-C5-induced T cell regulation. Our hypothesis was that exposure of the C5 peptide motif may have detrimental effects due to several of its HLA-like features and that enhancement of non-neutralising anti-C5 AB by vaccination could reduce C5 exposure and thereby chronic immune activation...
March 24, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28331078/tuberculin-skin-testing-boosts-interferon-gamma-responses-to-diva-reagents-in-mycobacterium-bovis-infected-cattle
#15
Gareth J Jones, Mick Coad, Bhagwati Khatri, Javier Bezos, Natalie A Parlane, Bryce M Buddle, Bernardo Villarreal-Ramos, R Glyn Hewinson, H Martin Vordermeier
BCG vaccination sensitises cattle to bovine tuberculin which compromises the use of the current bovine TB surveillance tests. Although the performance of a blood test (that utilises antigens expressed by Mycobacterium bovis but not by BCG) capable of discriminating infected from vaccinated animals (DIVA interferon-gamma test, DIT) has been evaluated in naturally infected TB field reactors, there is a need to perform similar analysis in a BCG vaccinated/M. bovis infected population. Furthermore, we explored different scenarios under which a DIT may be implemented alongside BCG vaccination: (i) serial testing to resolve potential false positive skin test results; or (ii) standalone test to replace the single intradermal comparative cervical tuberculin skin test (SICCT)...
March 22, 2017: Clinical and Vaccine Immunology: CVI
https://www.readbyqxmd.com/read/28321400/toward-elimination-of-dog-mediated-human-rabies-experiences-from-implementing-a-large-scale-demonstration-project-in-southern-tanzania
#16
Emmanuel Abraham Mpolya, Tiziana Lembo, Kennedy Lushasi, Rebecca Mancy, Eberhard M Mbunda, Selemani Makungu, Matthew Maziku, Lwitiko Sikana, Gurdeep Jaswant, Sunny Townsend, François-Xavier Meslin, Bernadette Abela-Ridder, Chanasa Ngeleja, Joel Changalucha, Zacharia Mtema, Maganga Sambo, Geofrey Mchau, Kristyna Rysava, Alphoncina Nanai, Rudovick Kazwala, Sarah Cleaveland, Katie Hampson
A Rabies Elimination Demonstration Project was implemented in Tanzania from 2010 through to 2015, bringing together government ministries from the health and veterinary sectors, the World Health Organization, and national and international research institutions. Detailed data on mass dog vaccination campaigns, bite exposures, use of post-exposure prophylaxis (PEP), and human rabies deaths were collected throughout the project duration and project areas. Despite no previous experience in dog vaccination within the project areas, district veterinary officers were able to implement district-wide vaccination campaigns that, for most part, progressively increased the numbers of dogs vaccinated with each phase of the project...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28317660/safety-tolerability-and-efficacy-of-intradermal-rabies-immunization-with-debioject%C3%A2
#17
Paul Vescovo, Nils Rettby, Nirinarilala Ramaniraka, Julie Liberman, Karen Hart, Astrid Cachemaille, Laurent-Dominique Piveteau, Reto Zanoni, Pierre-Alexandre Bart, Giuseppe Pantaleo
In a single-center study, 66 healthy volunteers aged between 18 and 50years were randomized to be immunized against rabies with three different injection routes: intradermal with DebioJect™ (IDJ), standard intradermal with classical needle (IDS), also called Mantoux method, and intramuscular with classical needle (IM). "Vaccin rabique Pasteur®" and saline solution (NaCl 0.9%) were administered at D0, D7 and D28. Antigen doses for both intradermal routes were 1/5 of the dose for IM. Tolerability, safety and induced immunogenicity of IDJ were compared to IDS and IM routes...
March 27, 2017: Vaccine
https://www.readbyqxmd.com/read/28300438/a-rare-case-of-oestrogen-dermatitis
#18
Emilie Bourgeault, Janie Bujold, Marie-Eve Doucet
BACKGROUND: Oestrogen dermatitis is a rare disorder characterised by cyclical eruptions in association with a woman's menstrual cycle. METHODS: A 43-year-old woman with an 8-year history of cyclical inguinal dermatitis, with a negative patch test, was tested with intradermal progesterone and oestrogen. RESULTS: Intradermal testing was positive for oestrogen only. CONCLUSION: In a female patient with cyclical dermatitis, it is important to consider oestrogen or progesterone dermatitis in the differential diagnosis...
December 1, 2016: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28294589/selective-hypersensitivity-to-cefazolin-and-contribution-of-the-basophil-activation-test
#19
J P Almeida, A Lopes, A Campos Melo, M C Pereira Santos, M Pereira Barbosa
The authors present 2 case reports of selective cefazolin hypersensitivity: a 49 year-old woman with a history of two perioperative reactions (urticaria and severe anaphylaxis) after the use of rocuronium, propophol and cefazolin; a 36 year-old pregnant woman who developed facial erythema, lips angioedema and hypotension immediately after administration of ropivacain, sufentanil, cefazolin, oxytocin and ephedrine. In both cases, intradermal skin tests were positive for cefazolin. A basophil activation test was performed for cefazolin, which was positive in one patient...
March 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28263785/nociceptive-neuronal-fc-gamma-receptor-i-is-involved-in-igg-immune-complex-induced-pain-in-the-rat
#20
Haowu Jiang, Xinhua Shen, Zhiyong Chen, Fan Liu, Tao Wang, Yikuan Xie, Chao Ma
Antigen-specific immune diseases such as rheumatoid arthritis are often accompanied by pain and hyperalgesia. Our previous studies have demonstrated that Fc-gamma-receptor type I (FcγRI) is expressed in a subpopulation of rat dorsal root ganglion (DRG) neurons and can be directly activated by IgG immune complex (IgG-IC). In this study we investigated whether neuronal FcγRI contributes to antigen-specific pain in the naïve and rheumatoid arthritis model rats. In vitro calcium imaging and whole-cell patch clamp recordings in dissociated DRG neurons revealed that only the small-, but not medium- or large-sized DRG neurons responded to IgG-IC...
March 2, 2017: Brain, Behavior, and Immunity
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