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https://www.readbyqxmd.com/read/28214496/new-diagnostic-modalities-in-the-evaluation-of-lymphedema
#1
REVIEW
Thomas F O'Donnell, John C Rasmussen, Eva M Sevick-Muraca
OBJECTIVE: Currently, lymphedema (LED) is typically diagnosed clinically on the basis of a patient's history and characteristic physical findings. Whereas the diagnosis of LED is sometimes confirmed by lymphoscintigraphy (LSG), the technique is limited in both its ability to identify disease and to guide therapy. Recent advancements provide opportunities for new imaging techniques not only to assist in the diagnosis of LED, based on anatomic changes, but also to assess contractile function and to guide therapeutic intervention...
March 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28194756/chlorhexidine-allergy-in-4-specialist-allergy-centres-in-the-uk-2009-2013-clinical-features-and-diagnostic-tests
#2
William Egner, Matthew Helbert, Ravishankar Sargur, Kirsty Swallow, Nigel Harper, Tomaz Garcez, Sinisa Savic, Louise Savic, Eren Effren
We describe an observational survey of diagnostic pathways in 104 patients attending four specialist allergy clinics in the UK following perioperative hypersensitivity reactions to chlorhexidine reactions. The majority were life threatening. Men undergoing urological or cardiothoracic surgery predominated. Skin prick testing and sIgE testing were the most common tests used for diagnosis. Fifty-three % of diagnoses were made on the basis of a single positive test. Where multiple tests were performed the sensitivity of intradermal, basophil activation and skin prick testing was 68% (50-86%), 50% (10-90%) and 35% (17-55%) respectively...
February 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28188907/safety-pharmacokinetic-and-pharmacodynamic-study-in-healthy-subjects-of-oral-neo6860-a-modality-selective-trpv1-antagonist
#3
William Brown, Richard L Leff, Andrew Griffin, Stuart Hossack, Roxane Aubray, Philippe Walker, Dan A Chiche
: Most previous TRPV1 antagonist programs have been put on hold, mainly due on-target adverse events: hyperthermia and impaired noxious heat sensation. NEO6860 is a TRPV1 antagonist, blocking capsaicin activation of the target, with little or no effect against pH or heat activation. The hypothesis is that this pharmacological profile will translate into analgesia without undesired effects on the body temperature or heat-pain threshold. This phase I, double blind, placebo controlled, ascending dose study, included 64 subjects...
February 7, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28152056/transmission-dynamics-and-elimination-potential-of-zoonotic-tuberculosis-in-morocco
#4
Mahamat Fayiz Abakar, Hind Yahyaoui Azami, Philipp Justus Bless, Lisa Crump, Petra Lohmann, Mirjam Laager, Nakul Chitnis, Jakob Zinsstag
Bovine tuberculosis (BTB) is an endemic zoonosis in Morocco caused by Mycobacterium bovis, which infects many domestic animals and is transmitted to humans through consumption of raw milk or from contact with infected animals. The prevalence of BTB in Moroccan cattle is estimated at 18%, and 33% at the individual and the herd level respectively, but the human M. bovis burden needs further clarification. The current control strategy based on test and slaughter should be improved through local context adaptation taking into account a suitable compensation in order to reduce BTB prevalence in Morocco and decrease the disease burden in humans and animals...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28134065/effect-of-host-diversity-and-species-assemblage-composition-on-bovine-tuberculosis-btb-risk-in-ethiopian-cattle
#5
Dejene W Sintayehu, Ignas M A Heitkönig, Herbert H T Prins, Zewdu K Tessema, Willem F DE Boer
Current theories on diversity-disease relationships describe host species diversity and species identity as important factors influencing disease risk, either diluting or amplifying disease prevalence in a community. Whereas the simple term 'diversity' embodies a set of animal community characteristics, it is not clear how different measures of species diversity are correlated with disease risk. We therefore tested the effects of species richness, Pielou's evenness and Shannon's diversity on bovine tuberculosis (bTB) risk in cattle in the Afar Region and Awash National Park between November 2013 and April 2015...
January 30, 2017: Parasitology
https://www.readbyqxmd.com/read/28130998/investigations-and-implications-of-associations-between-mycobacterial-purified-protein-derivative-hypersensitivity-and-map-antibody-elisa-in-irish-dairy-cows
#6
A E Kennedy, N Byrne, J O'Mahony, R G Sayers
Intradermal testing, involving administration of purified protein derivative (PPD), to elicit a delayed hypersensitivity (DTH) response, is used as a diagnostic tool for bovine tuberculosis (bTB) and to aid in the identification of exposure to Mycobacterium avium subspecies paratuberculosis (MAP), the causative agent of Johne's disease (JD). Further research is required to increase the diagnostic value of skin testing for MAP. The aim of this study was to investigate if animals showing DTH reactions to PPD had an associated increase in MAP ELISA response, thereby identifying potential cases of sub-clinical JD...
January 21, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28125796/three-year-follow-up-of-gmcsf-bi-shrna-furin-dna-transfected-autologous-tumor-immunotherapy-vigil-in-metastatic-advanced-ewing-s-sarcoma
#7
Maurizio Ghisoli, Minal Barve, Robert Mennel, Carl Lenarsky, Staci Horvath, Gladice Wallraven, Beena O Pappen, Sam Whiting, Donald Rao, Neil Senzer, John Nemunaitis
Ewing's sarcoma is a devastating rare pediatric cancer of the bone. Intense chemotherapy temporarily controls disease in most patients at presentation but has limited effect in patients with progressive or recurrent disease. We previously described preliminary results of a novel immunotherapy, FANG (Vigil) vaccine, in which 12 advanced stage Ewing's patients were safely treated and went on to achieve a predicted immune response (IFNγ ELISPOT). We describe follow-up through year 3 of a prospective, nonrandomized study comparing an expanded group of Vigil-treated advanced disease Ewing's sarcoma patients (n = 16) with a contemporaneous group of Ewing's sarcoma patients (n = 14) not treated with Vigil...
August 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28125513/a-dendritic-cell-vaccine-combined-with-radiotherapy-activates-the-specific-immune-response-in-patients-with-esophageal-cancer
#8
Chengshi Wang, Juan Pu, Hanxu Yu, Yanyan Liu, Honghuan Yan, Zhongxiang He, Xin Feng
Dendritic cells (DC) are highly efficient antigen-presenting cells. DC may be used to create DC vaccines against cancer, but the optimal strategies remain to be elucidated. This study aimed to examine the benefits and adverse effects of using esophageal cancer cell antigens to stimulate DC to trigger the specific immune response in patients with esophageal cancer undergoing radiotherapy. This was an observational cohort study performed at Lianshui County People's Hospital between September 2010 and June 2012...
February 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28114394/proteomic-analysis-of-kveim-reagent-identifies-targets-of-cellular-immunity-in-sarcoidosis
#9
Christian Eberhardt, Muhunthan Thillai, Robert Parker, Nazneen Siddiqui, Lee Potiphar, Rob Goldin, John F Timms, Athol U Wells, Onn M Kon, Melissa Wickremasinghe, Donald Mitchell, Mark E Weeks, Ajit Lalvani
BACKGROUND: Kveim-reagent (Kv) skin testing was a historical method of diagnosing sarcoidosis. Intradermal injection of treated sarcoidosis spleen tissue resulted in a granuloma response at injection site by 4-6 weeks. Previous work indicates proteins as the possible trigger of this reaction. We aimed to identify Kv-specific proteins and characterise the ex vivo response of Peripheral Blood Mononuclear Cells (PBMCs) from sarcoidosis, tuberculosis and healthy control patients when stimulated with both Kv and selected Kv-specific proteins...
2017: PloS One
https://www.readbyqxmd.com/read/28112529/frequency-and-risk-factors-of-penicillin-and-amoxicillin-allergy-in-suspected-patients-with-drug-allergy
#10
Mohammad Reza Fazlollahi, Katayoon Bidad, Raheleh Shokouhi, Raheleh Dashti, Mohammad Nabavi, Masoud Movahedi, Mohammad Hasan Bemanian, Ali Reza Shafiei, Najmoddin Kalantari, Effat Sadat Farboud, Zahra Pourpak, Mostafa Moin
BACKGROUND: Unconfirmed beta-lactam allergy is a significant public health problem because of the limitations it imposes in drug selection. In this study, we aimed to evaluate patients referred for beta-lactam allergy to determine the frequency of confirmed beta-lactam allergy and identify some risk factors. METHODS: In a prospective cohort study, all referred patients to Immunology, Asthma and Allergy Research Institute in Tehran University of Medical Sciences (between 2007 - 2009) who suspected to have beta-lactam allergy were entered into this study based on having the inclusion criteria...
January 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28107879/disease-transmission-in-animal-transfer-networks
#11
Dejene W Sintayehu, H H T Prins, I M A Heitkönig, W F de Boer
Infectious diseases transmission is strongly determined by who contacts whom. Bovine tuberculosis (bTB) caused by Mycobacterium bovis is a worldwide burden for animal populations. One of the major transmission mechanism between herd is the transfer of infectious animal. In East Africa, pastoralists may receive or bestow livestock to create and strengthen social relationships. Here, we used a network approach to examine the relative importance of such cattle transfer in the transmission of bTB. First, a total of 2550 cattle from 102 herds were tested using the comparative intradermal tuberculin test to assess the presence of bTB infected cattle in the herd...
February 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28100257/food-specific-sublingual-immunotherapy-is-well-tolerated-and-safe-in-healthy-dogs-a-blind-randomized-placebo-controlled-study
#12
RANDOMIZED CONTROLLED TRIAL
E Maina, M Pelst, M Hesta, E Cox
BACKGROUND: Food allergies are increasing in prevalence but no treatment strategies are currently available to cure dogs with food allergy. Over the past decade, experimental food allergen-specific sublingual immunotherapy (FA-SLIT) has emerged as a potential treatment for food allergies in human medicine. However, FA-SLIT has not been investigated in dogs. Therefore, the objective of this study was to prospectively evaluate the safety, tolerability and dispenser sterility of FA-SLIT in healthy dogs before testing it in food allergic dogs...
January 18, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28096613/immunotoxic-effect-of-thiamethoxam-in-immunized-mice-with-brucella-abortus-cultural-filtrate-antigen
#13
L H Salema, M J Alwan, Afaf Abdulrahman Yousif
AIM: This study was planned for determination the toxic effect of thiamethoxam (TMX) in immunized mice with Brucella abortus culture filtrate antigen (CFBAgs) (as a vaccine) and its role of TMX on decrease activity of B. abortus antigen on eliciting of humoral and cellular immunity. MATERIALS AND METHODS: To achieve these goals 60 female mice were used, 7-8 weeks age, they were divided equally into three groups (20 in each group) and treated as follows: 1(st) group: Mice were immunized with CFBAgs intraperitoneally in two doses, 2 weeks intervals with (protein concentration 2 mg\ml), 2(nd) group: Mice immunized as in the 1(st) group and was administrated orally with 1/10 lethal dose 50% of TMX (83...
December 2016: Veterinary World
https://www.readbyqxmd.com/read/28077533/cefalotin-as-antimicrobial-prophylaxis-in-patients-with-known-intraoperative-anaphylaxis-to-cefazolin
#14
P H M Sadleir, R C Clarke, P R Platt
BACKGROUND: The most common trigger for intraoperative anaphylaxis in Western Australia for the period 2014-5 was an antibiotic used for surgical prophylaxis, cefazolin. In these patients who subsequently present for surgery, alternative cephalosporins are forbidden by current guidelines because of concerns regarding an increased risk of anaphylaxis. However, consideration of the structure-activity relationships relevant to anaphylaxis suggests that cefalotin is a safe alternative because of structural dissimilarities, although there are no pubished clinical data relevant to the perioperative setting...
October 2016: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28072845/tuberculosis-detection-in-paratuberculosis-vaccinated-calves-new-alternatives-against-interference
#15
Miriam Serrano, Natalia Elguezabal, Iker A Sevilla, María V Geijo, Elena Molina, Rakel Arrazuria, Alfonso Urkitza, Gareth J Jones, Martin Vordermeier, Joseba M Garrido, Ramón A Juste
Paratuberculosis vaccination in cattle has been restricted due to its possible interference with the official diagnostic methods used in tuberculosis eradication programs. To overcome this drawback, new possibilities to detect Mycobacterium bovis infected cattle in paratuberculosis vaccinated animals were studied under experimental conditions. Three groups of 5 calves each were included in the experiment: one paratuberculosis vaccinated group, one paratuberculosis vaccinated and M. bovis infected group and one M...
2017: PloS One
https://www.readbyqxmd.com/read/28061860/preliminary-investigation-of-the-transmission-of-tuberculosis-between-farmers-and-their-cattle-in-smallholder-farms-in-northwestern-ethiopia-a-cross-sectional-study
#16
Anwar Nuru, Gezahegne Mamo, Aboma Zewude, Yitayal Mulat, Gashaw Yitayew, Aschalew Admasu, Girmay Medhin, Rembert Pieper, Gobena Ameni
BACKGROUND: The feeding habits and close physical contact between Ethiopian farmers and their cattle promote the transmission of tuberculosis (TB) between the farmers and their cattle. This study aimed to investigate the transmission of TB between farmers and their cattle in smallholder farms in northwestern Ethiopia. RESULTS: A total of 70 human TB lymphadenitis (TBLN) cases visiting the Felegehiwot Comprehensive Specialized Hospital in Bahir Dar City and 660 cattle were investigated...
January 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28056956/effectiveness-of-regionally-specific-immunotherapy-for-the-management-of-canine-atopic-dermatitis
#17
Jon D Plant, Moni B Neradilek
BACKGROUND: Canine atopic dermatitis is a common pruritic skin disease often treated with allergen immunotherapy (AIT). AIT in dogs traditionally begins with attempting to identify clinically relevant environmental allergens. Current allergen testing methodologies and immunotherapy techniques in dogs are not standardized. Immunotherapy with a mixture of allergenic extracts selected based on regional aerobiology rather than intradermal tests or serum IgE assays has been described. The objective of this study was to evaluate the effectiveness of regionally-specific immunotherapy in dogs with atopic dermatitis...
January 5, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28049204/rapid-drug-desensitization-with-biologics-a-single-center-experience-with-four-biologics
#18
Sevim Bavbek, Reşat Kendirlinan, Pamir Çerçi, Seda Altıner, Şadan Soyyiğit, Zeynep Çelebi Sözener, Ömür Aydın, Reyhan Gümüşburun
BACKGROUND: Rapid drug desensitization (RDD) induces a temporary tolerance to biologics which induce hypersensitivity reactions (HSRs). Data are limited regarding the use of RDD outside the USA. Our purpose was to report our data on RDD to rituximab, infliximab, cetuximab, and trastuzumab. METHODS: The study was conducted as a retrospective chart review of patients with symptoms of HSRs to biologics. HSRs were classified as grades I, II, and III, based on their severity...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27999603/polyethylene-glycol-as-a-cause-of-anaphylaxis
#19
Katharina Wylon, Sabine Dölle, Margitta Worm
BACKGROUND: Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food. CASE REPORT: We report on a Caucasian patient experiencing recurrent severe allergic reactions to several drugs. An extensive diagnostic workup including skin prick tests, intradermal tests (IDT) and a double-blind oral challenge was performed to identify the trigger of anaphylaxis. In the present case hypersensitivity to the additive polyethylene glycol was confirmed by an IDT suggesting an Immunoglobulin E-dependent mechanism as a cause of the reaction...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27996941/ige-api-m-4-is-useful-for-identifying-a-particular-phenotype-of-bee-venom-allergy
#20
B Ruiz, P Serrano, C Moreno
BACKGROUND AND OBJECTIVE: Different clinical behaviors have been identified in patients allergic to bee venom. Compound-resolved diagnosis could be an appropriate tool for investigating these differences. The aims of this study were to analyze whether specific IgE to Api m 4 (sIgE-Api m 4) can identify a particular kind of bee venom allergy and to describe response to bee venom immunotherapy (bVIT). METHODS: Prospective study of 31 patients allergic to bee venom who were assigned to phenotype group A (sIgE-Api m 4 <0...
2016: Journal of Investigational Allergology & Clinical Immunology
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