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Dissociative Identity Disorder

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https://www.readbyqxmd.com/read/28812237/pharmacological-effects-on-ceroid-lipofuscin-and-neuronal-structure-in-cln3-%C3%A2-ex7-8-mouse-brain-cultures
#1
Douglas E Brenneman, David A Pearce, Attila Kovacs, Shawn DeFrees
Juvenile Batten disease (JBD) is an inherited disorder that is characterized by the development of blindness, seizures, and progressive motor, psychiatric, and cognitive impairment. A model of JBD expressing the predominant human mutation (Cln3 (∆ex7/8) ) has been explored. Dissociated brain cultures from Cln3 (∆ex7/8) knock-in mice were compared to wild type (WT) for effects on granules of ceroid lipofuscin (CL) and neuronal structure. Utilizing high content image analysis of CL granules identified with antibodies to mitochondrial ATP synthase subunit c or tripeptidyl peptidase-1, significant increases in the areas for both immunoreactive granules were observed in Cln3 (∆ex7/8) cultures in comparison to WT...
August 15, 2017: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/28803140/a-competent-catalytic-active-site-is-necessary-for-substrate-induced-dimer-assembly-in-triosephosphate-isomerase
#2
Pedro Jimenez-Sandoval, Jose Luis Vique-Sanchez, Marisol López Hidalgo, Gilberto Velazquez-Juarez, Corina Diaz-Quezada, Luis Fernando Arroyo-Navarro, Gabriela Montero Moran, Juliana Fattori, A Jessica Diaz-Salazar, Enrique Rudiño-Pinera, Rogerio Sotelo-Mundo, Ana Carolina Migliorini Figueira, Samuel Lara-Gonzalez, Claudia G Benítez-Cardoza, Luis G Brieba
The protozoan parasite Trichomonas vaginalis contains two nearly identical triosephosphate isomerases (TvTIMs) that dissociate into stable monomers and dimerize upon substrate binding. Herein, we compare the role of the "ball and socket" and loop 3 interactions in substrate assisted dimer assembly in both TvTIMs. We found that point mutants at the "ball" are only 39 and 29-fold less catalytically active than their corresponding wild-type counterparts, whereas loop 3 deletions are 1502 and 9400-fold less active...
August 9, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28797561/self-reported-psychosis-like-experiences-in-patients-with-mood-disorders
#3
I Baryshnikov, J Suvisaari, K Aaltonen, M Koivisto, T Melartin, P Näätänen, K Suominen, B Karpov, M Heikkinen, J Oksanen, T Paunio, G Joffe, E Isometsä
BACKGROUND: Self-reported psychosis-like experiences (PEs) may be common in patients with mood disorders, but their clinical correlates are not well known. We investigated their prevalence and relationships with self-reported symptoms of depression, mania, anxiety, borderline (BPD) and schizotypal (SPD) personality disorders among psychiatric patients with mood disorders. METHODS: The Community Assessment of Psychic Experiences (CAPE-42), Mood Disorder Questionnaire (MDQ), McLean Screening Instrument (MSI), The Beck Depressive Inventory (BDI), Overall Anxiety Severity and Impairment Scale (OASIS) and Schizotypal Personality Questionnaire-Brief form (SPQ-B) were filled in by patients with mood disorders (n=282) from specialized care...
February 3, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28745945/elena-a-case-of-dissociative-identity-disorder-from-the-1920s
#4
Adriano Schimmenti
In 1930, Italian psychiatrist Giovanni Enrico Morselli described the history, diagnosis, and treatment of his patient Elena. The case of Elena has been considered in literature as one of the most remarkable cases of multiple personality ever published. In fact, before treatment, Elena showed alternating French- and Italian-speaking personalities, with the Italian personality knowing nothing of her French counterparts. After a difficult treatment involving recovered memories of incestuous attacks by her father, which were proven to be true, Elena fully recovered from her symptoms...
July 26, 2017: Bulletin of the Menninger Clinic
https://www.readbyqxmd.com/read/28745157/exceptional-nurse-saved-my-life-after-mental-health-diagnosis
#5
(no author information available yet)
When I first met Karen Coutts at a mental health inpatient unit in Lancashire, I was at the lowest point of my life, having been diagnosed with dissociative identity disorder.
July 26, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28741044/efficacy-and-tolerability-of-asenapine-compared-with-olanzapine-in-borderline-personality-disorder-an-open-label-randomized-controlled-trial
#6
Paola Bozzatello, Paola Rocca, Maria Uscinska, Silvio Bellino
BACKGROUND: Asenapine is a new second-generation antipsychotic that is understudied in borderline personality disorder (BPD). Only one study investigating the use of the drug in this indication (an open-label pilot study) has been conducted to date. OBJECTIVE: The present open-label, randomized, controlled trial aimed to evaluate the efficacy and tolerability of asenapine in comparison with olanzapine, the most broadly studied antipsychotic in BPD. METHODS: A total of 51 outpatients aged between 18 and 50 years with a diagnosis of BPD based on Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria were assigned for 12 weeks to asenapine (5-10 mg/day) or olanzapine (5-10 mg/day)...
July 24, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28659840/multiplicity-an-explorative-interview-study-on-personal-experiences-of-people-with-multiple-selves
#7
Gergő Ribáry, László Lajtai, Zsolt Demetrovics, Aniko Maraz
Background and aims: Personality psychology research relies on the notion that humans have a single self that is the result of the individual's thoughts, feelings, and behaviors that can be reliably described (i.e., through traits). People who identify themselves as "multiple" have a system of multiple or alternative, selves, that share the same physical body. This is the first study to explore the phenomenon of multiplicity by assessing the experiences of people who identify themselves as "multiple." Methods: First, an Internet forum search was performed using the terms "multiplicity" and "multiple system...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28559875/beyond-the-impasse-reflections-on-dissociative-identity-disorder-from-a-freudian-lacanian-perspective
#8
Reitske Meganck
Dissociative identity disorder (DID) is a widely contested diagnosis. The dominant posttraumatic model (PTM) considers early life trauma to be the direct cause of the creation of alter identities and assumes that working directly with alter identities should be at the core of the therapeutic work. The socio-cognitive model, on the other hand, questions the validity of the DID diagnosis and proposes an iatrogenic origin of the disorder claiming that reigning therapeutic and socio-cultural discourses create and reify the problem...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28545341/interidentity-amnesia-in-dissociative-identity-disorder
#9
John Morton
INTRODUCTION: Patients diagnosed with dissociative identity disorder (DID) usually present with alternative personality states (alters) who take separate control of consciousness. Commonly, one alter will claim they have no awareness of events which took place when another alter was in control. However, some kinds of material are transferred across the alter boundary. Huntjens et al. devised an objective method of demonstrating such transfer. METHODS: In the main study, following Huntjens et al...
July 2017: Cognitive Neuropsychiatry
https://www.readbyqxmd.com/read/28496375/revisiting-the-etiological-aspects-of-dissociative-identity-disorder-a-biopsychosocial-perspective
#10
REVIEW
Vedat Şar, Martin J Dorahy, Christa Krüger
Dissociative identity disorder (DID) is a chronic post-traumatic disorder where developmentally stressful events in childhood, including abuse, emotional neglect, disturbed attachment, and boundary violations are central and typical etiological factors. Familial, societal, and cultural factors may give rise to the trauma and/or they may influence the expression of DID. Memory and the construction of self-identity are cognitive processes that appear markedly and centrally disrupted in DID and are related to its etiology...
2017: Psychology Research and Behavior Management
https://www.readbyqxmd.com/read/28467630/psychological-traits-predict-impaired-awareness-of-deficits-independently-of-neuropsychological-factors-in-chronic-traumatic-brain-injury
#11
Zorry Belchev, Neta Levy, Itamar Berman, Hila Levinzon, Dan Hoofien, Asaf Gilboa
OBJECTIVES: To dissociate injury-related factors from psychological contributions to impaired awareness of deficits following traumatic brain injury (TBI); impaired awareness is theorized to partly reflect psychological factors (e.g., denial), but empirical evidence for this theory is scarce. DESIGN: We examined how different factors predict awareness in patients undergoing rehabilitation (N = 43). Factors included (1) neurological (injury severity), (2) neuropsychological loss, (3) psychological (denial, projection, identification), and (4) personality (narcissism)...
May 3, 2017: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28460585/navigating-undiagnosed-dissociative-identity-disorder-in-the-inpatient-setting-a-case-report
#12
Theresa M Urbina, Tania May, Michelle Hastings
BACKGROUND: This case illustrates previously undiagnosed dissociative identity disorder (DID) in a middle-aged female with extensive childhood trauma, who was high functioning prior to a trigger that caused a reemergence of her symptoms. The trigger sparked a dissociative state, attempted suicide, and subsequent inpatient psychiatric hospitalization. OBJECTIVE: Practitioners should include in their differential and screen for undiagnosed DID in patients with episodic psychiatric hospitalizations refractory to the standard treatments for previously diagnosed mental illnesses...
May 2017: Journal of the American Psychiatric Nurses Association
https://www.readbyqxmd.com/read/28424054/an-unusual-delusion-of-duplication-in-a-patient-affected-by-dementia-with-lewy-bodies
#13
Paolo Solla, Gioia Mura, Antonino Cannas, Gianluca Floris, Davide Fonti, Gianni Orofino, Mauro Giovanni Carta, Francesco Marrosu
BACKGROUND: Dementia with Lewy bodies (DLB) is the second most frequent diagnosis of progressive degenerative dementia in older people. Delusions are common features in DLB and, among them, Capgras syndrome represents the most frequent disturbance, characterized by the recurrent and transient belief that a familiar person, often a close family member or caregiver, has been replaced by an identical-looking imposter. However, other delusional conditions near to misidentification syndromes can occur in DLB patients and may represent a major psychiatric disorder, although rarely studied systematically...
April 19, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28348911/a-case-of-persistent-generalized-retrograde-autobiographical-amnesia-subsequent-to-the-great-east-japan-earthquake-in-2011
#14
Yuji Odagaki
Functional retrograde autobiographical amnesia is often associated with physical and/or psychological trauma. On 11 March 2011, the largest earthquake on record in Japan took place, and subsequent huge tsunami devastated the Pacific coast of northern Japan. This case report describes a patient suffering from retrograde episodic-autobiographical amnesia for whole life, persisting for even more than five years after the disaster. A Japanese man, presumably in his 40s, got police protection in April 2016 but was unable to respond to question about his own name...
2017: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/28332952/dying-for-love-an-attachment-problem-with-some-perpetrator-introjects
#15
Valerie Sinason
This paper focuses on some problematic victim-perpetrator dynamics in psychotherapy with patients with Dissociative Identity Disorder where there has been longstanding multi-perpetrator organized abuse described, which also involves family members. Additionally, in this specific sample, there have been reported experiences of serious assaults from attachment figures in which the patient felt close to death. The clinical concern is expressed that only in the nearness of death is a connection felt to the attachment figure and this leads to extra suicidality in the patient and extra vulnerability to secondary traumatization for the therapist...
May 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28318413/treatment-strategies-for-programming-and-ritual-abuse
#16
Colin Ross
Individuals in treatment for dissociative identity disorder not uncommonly describe childhood involvement in organized, multi-perpetrator ritual abuse. They described being "programmed" by the perpetrators and feel that the programming is out of their control. The author has developed a set of treatment strategies and interventions for such cases. These are based on the principle of therapeutic neutrality and can be used no matter what assumptions the therapist makes about the historical accuracy of the memories and beliefs...
May 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28301038/shame-dissociation-and-complex-ptsd-symptoms-in-traumatized-psychiatric-and-control-groups-direct-and-indirect-associations-with-relationship-distress
#17
Martin J Dorahy, Mary Corry, Rebecca Black, Laura Matheson, Holly Coles, David Curran, Lenaire Seager, Warwick Middleton, Kevin F W Dyer
OBJECTIVES: Elevated shame and dissociation are common in dissociative identity disorder (DID) and chronic posttraumatic stress disorder (PTSD) and are part of the constellation of symptoms defined as complex PTSD. Previous work examined the relationship between shame, dissociation, and complex PTSD and whether they are associated with intimate relationship anxiety, relationship depression, and fear of relationships. This study investigated these variables in traumatized clinical samples and a nonclinical community group...
April 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28281921/lateralization-of-neurobiological-response-in-adolescents-with-post-traumatic-stress-disorder-related-to-severe-childhood-sexual-abuse-the-tri-modal-reaction-t-mr-model-of-protection
#18
Tuba Mutluer, Vedat Şar, Çiğdem Kose-Demiray, Harun Arslan, Sibel Tamer, Serap Inal, Anıl Ş Kaçar
This study inquires into neurobiological response to stress and its clinical correlates among adolescents with post-traumatic stress disorder (PTSD). Structural magnetic resonance imaging (MRI) measures of cerebral anatomy were carried out on 23 female adolescents with PTSD related to severe childhood sexual abuse and 21 matched healthy controls. Clinician Administered PTSD Scale for Children and Adolescents, Adolescent Dissociative Experiences Scale, Childhood Trauma Questionnaire, Schedule for Affective Disorders and Schizophrenia for School Age Children, Beck Depression Scale, and a set of neuro-cognitive tests were administered to all participants...
March 10, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28277976/issues-in-consultation-for-treatments-with-distressed-activated-abuser-protector-self-states-in-dissociative-identity-disorder
#19
Richard A Chefetz
The identified "problem self-state" in a dissociative disorder consultation is like the identified patient in a family therapy; the one who is identified may have an assigned role to be blamed which serves the function of deflecting the activities of painful self-states in other family members. In consultation, the "family" includes the therapist in addition to the patient. When the state identified as a problem self-state is an abuser/protector self-state, complications often involve the profound nature of transference-countertransference enactments between patient and therapist, the delusion of separateness, chronic and acute threats of suicide, negative therapeutic reactions, and the evocation of intense negativity...
May 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28277975/weaponized-sex-defensive-pseudo-erotic-aggression-in-the-service-of-safety
#20
Richard P Kluft
Problematic sexual behaviors are frequently encountered in the treatment of patients suffering Dissociative Identity Disorder and related forms of dissociative disorders. These may include unfortunate patterns of ready acquiescence or submission to overtly or potentially aggressive or sexual approaches/encounters, subtle and/or overt seductive signaling and behaviors, and even overt sexually provocative patterns of verbalizations and actions. This paper discusses the possibility that in some instances, sexual behavior has become weaponized; that is, deployed in circumstances under which assertiveness and/or aggression or other self-protective measures might be expected, probably because such behaviors were not within the range of the possible or were not understood as potentially successful for some victims of trauma...
May 2017: Journal of Trauma & Dissociation
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