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https://www.readbyqxmd.com/read/29329933/combined-hepatic-and-pulmonary-metastasectomies-from-colorectal-carcinoma-data-from-the-prospective-spanish-registry-2008-2010
#1
Jose R Jarabo, Ana M Gómez, Joaquín Calatayud, Carlos A Fraile, Elena Fernández, Nuria Pajuelo, Raul Embún, Laureano Molins, Juan J Rivas, Florentino Hernando
INTRODUCTION: Resection of both liver and lung metastases from colorectal carcinoma (CRC) is a standard of care in selected patients with oligometastatic disease. We present here the analysis of the subgroup of patients undergoing combined surgery from the Spanish Group of Surgery of Pulmonary Metastases (PM) from Colorectal Carcinoma (GECMP-CCR-SEPAR). METHODS: We analyze characteristics, survival and prognostic factors of patients undergoing combined resection from March-2008 to February-2010 and followed-up during at least 3 years, from the prospective multicenter Spanish Registry...
January 9, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29324212/managing-patients-with-oligometastatic-non-small-cell-lung-cancer
#2
Sarah Jo Stephens, Michael J Moravan, Joseph K Salama
Metastatic lung cancer has long been considered incurable, with the goal of treatment being palliation. However, a clinically meaningful number of these patients with limited metastases (approximately 25%) are living long term after definitive treatment to all sites of active disease. These patients with so-called oligometastatic disease likely represent a distinct clinical group who may possess a more indolent biology compared with their more widely metastatic counterparts. Hellman and Weichselbaum proposed the existence of the oligometastatic state, on the basis of the spectrum theory of cancer spread...
January 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29315736/dosing-oxaliplatin-in-a-haemodialysis-patient-with-metastatic-rectum-cancer-monitored-by-free-platinum-concentrations
#3
I R F van Berlo-van de Laar, W J Brummelhuis, A L T Imholz, J H Schellens, A D R Huitema, F G A Jansman
WHAT IS KNOWN AND OBJECTIVE: Oxaliplatin in combination with fluorouracil and folinic acid is one of the preferred chemotherapeutic options in the treatment of metastatic rectum cancer. However, oxaliplatin is contraindicated in patients with a creatinine clearance <30 mL/min and dosing guidelines in patients on haemodialysis have not been established. CASE SUMMARY: A 77-year-old haemodialysis patient with metastatic rectum cancer was treated with FOLFOX and bevacizumab (oxaliplatin 70 mg/m2 , folinic acid 200 mg/m2 , 5-FU 340 mg/m2 bolus and 2040 mg/m2 continuous infusion during 44 hours and bevacizumab 5 mg/kg) every three weeks...
January 5, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29302953/utilization-of-targeted-near-infrared-molecular-imaging-to-improve-pulmonary-metastasectomy-of-osteosarcomas
#4
Jarrod D Predina, Andrew Newton, Charuhas Deshpande, Philip Low, Sunil Singhal
Pulmonary metastasectomy for osteosarcoma provides a select group of patients an opportunity for long-term survival and possible cure. Unfortunately, a complete metastasectomy is challenging due an inability to accurately identify lesions that lay below the threshold of preoperative imaging or intraoperative visual and tactile inspection. Growing evidence suggests that osteosarcomas express a number of unique molecular markers, including the folate receptor alpha. In this case report, we describe the application of a folate receptor-targeted, near-infrared optical contrast agent (OTL38) to improve osteosarcoma localization during minimally invasive pulmonary resection...
January 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29285651/a-long-term-survival-case-treated-with-conversion-surgery-following-chemotherapy-after-diagnostic-metastasectomy-for-pancreatic-cancer-with-synchronous-liver-metastasis
#5
Mitsuhiro Shimura, Masamichi Mizuma, Hiroki Hayashi, Akiko Mori, Tomoyoshi Tachibana, Tatsuo Hata, Masahiro Iseki, Tatsuyuki Takadate, Kyohei Ariake, Shimpei Maeda, Hideo Ohtsuka, Naoaki Sakata, Takanori Morikawa, Kei Nakagawa, Takeshi Naitoh, Takashi Kamei, Fuyuhiko Motoi, Michiaki Unno
BACKGROUND: Pancreatic cancer with distant metastases is classified as "unresectable," for which the standard treatment is systemic chemotherapy. The effectiveness of radical resection for pancreatic cancer with distant metastases is unknown. Here, we report a case of long term survival treated with conversion surgery following chemotherapy after diagnostic metastasectomy for pancreatic cancer with synchronous liver metastasis. CASE PRESENTATION: A 73-year-old man was referred to our hospital to examine and treat for cancer of the pancreatic body...
December 29, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29281872/prognoses-and-clinical-outcomes-of-primary-and-recurrent-uveal-melanoma
#6
Jee Hung Kim, Su-Jin Shin, Soo Jin Heo, Eun-Ah Choe, Chang-Gon Kim, Minkyu Jung, Ki Chang Keum, Jin Sook Yoon, Sung Chul Lee, Sang Joon Shin
Purpose: Uveal melanoma has a very poor prognosis despite successful local primary tumor treatment. In this study, we investigated prognostic factors that more accurately reflected the likelihood of recurrence and survival and delineated a prognostic model that could effectively identify different risk groups based on initial clinical parameters. Materials and Methods: Prognostic factors associated with distant recurrence, recurrence-free survival (RFS), progression-free survival (PFS), and OS from distant recurrence to death (OS2) were analyzed in 226 patients with stage I-III uveal melanoma who underwent primary local therapy...
December 28, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29275320/influence-of-obesity-on-the-course-of-malignant-neoplastic-disease-in-patients-after-pulmonary-metastasectomy
#7
Adam Rzechonek, Piotr Błasiak, Grzegorz Pniewski, Piotr Cierpikowski, Monika Mościbrodzka, Maciej Ornat, Jędrzej Grzegrzółka, Anna Brzecka
BACKGROUND/AIM: The aim of the study was to determine whether increased body mass index (BMI) in patients operated on for lung metastases influences the course of the disease. MATERIALS AND METHODS: The retrospective data of 97 patients previously operated on for different malignancies were analyzed. There were 40 obese patients (BMI >30 kg/m2, mean 33.9±4.5) and 57 non-obese patients (BMI 25.8±2.7 kg/m2, p<0.001). Disease-free interval (DFI), the overall survival (OS) and survival after pulmonary metastasectomy were analyzed...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29260342/predictors-for-a-further-local-in-brain-progression-after-re-craniotomy-of-locally-recurrent-cerebral-metastases
#8
Marcel A Kamp, Igor Fischer, Maxine Dibué-Adjei, Christopher Munoz-Bendix, Jan-Frederick Cornelius, Hans-Jakob Steiger, Philipp J Slotty, Bernd Turowski, Marion Rapp, Michael Sabel
Treatment of recurrent cerebral metastases is an emerging challenge due to the high local failure rate after surgery or radiosurgery and the improved prognosis of patients with malignancies. A total of 36 patients with 37 metastases who underwent surgery for a local in-brain progression of a cerebral metastasis after previous metastasectomy were retrospectively analyzed. Degree of surgical resection on an early postoperative MRI within 72 h after surgery was correlated with the local in-brain progression rate and overall survival...
December 20, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29255095/mesenteric-fibrosis-and-palliative-surgery-in-small-intestinal-neuroendocrine-tumours
#9
Anela Blazevic, Wouter T Zandee, Gaston J H Franssen, Johannes Hofland, Marie-Louise F Van Velthuysen, Leo Hofland, R A Feelders, Wouter W de Herder
Mesenteric fibrosis (MF) surrounding a mesenteric mass is a hallmark feature of small intestinal neuroendocrine tumours (SI-NETs). Since this can induce intestinal obstruction, oedema and ischaemia, prophylactic resection of the primary tumour and mesenteric mass is often recommended. This study assessed predictors for mesenteric metastasis and fibrosis and the effect of MF and palliative surgery on survival. This study is a retrospective analysis of 559 patients with pathologically proven SI-NET and available CT-imaging data was performed...
December 18, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29235005/correction-to-metastasectomy-for-tumor-infiltrating-lymphocytes-an-emerging-operative-indication-in-surgical-oncology
#10
Joseph G Crompton, Nicholas D Klemen, Udai S Kammula
In the original article the middle initial of Nicholas D. Klemen was inadvertently omitted. On the first page of the original article, under the heading A Novel Way to Fight Cancer, there was an error in the third sentence. The corrected text is as follows: For example, the presence of T cells within tumors of colorectal origin can be a superior predictor of patient survival compared with the standard histopathologic methods currently used to stage colorectal cancer.6,7.
December 12, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29234633/clinical-factors-predicting-better-survival-outcome-for-pulmonary-metastasectomy-of-hepatocellular-carcinoma
#11
Tse-Ming Kuo, Kai-Ming Chang, Tsun-I Cheng, Kuo-Jang Kao
Background: In patients with lung metastasis of hepatocellular carcinoma (HCC), it remains uncertain how a better survival outcome can be predicted after metastasectomy. This study aims to identify clinical factors that may be used to guide patient selection for such a therapeutic modality. A total of 28 patients who received pulmonary metastasectomy for HCC between 1993 and 2012 were identified. All relevant clinical factors were extracted from medical records up to September 2015. Patients were classified into high- and low-risk groups according to survival outcome after metastasectomy...
November 2017: Liver Cancer
https://www.readbyqxmd.com/read/29234265/the-benefit-of-a-surgical-resection-of-a-solitary-pulmonary-metastasis-of-prostate-cancer-after-radical-prostatectomy
#12
Dries Mortier, Evert Baten, Kurt Vandeurzen, Koenraad van Renterghem
Historically, a solitary pulmonary metastasis of prostate cancer was considered as metastatic or disseminated disease and could only be treated systemically. However, some patients may benefit from surgical metastasectomy of a solitary pulmonary metastasis. We present an uncommon case of resection of a solitary pulmonary metastasis of prostate cancer after previous radical prostatectomy, resulting in un-detectable prostate specific antigen.
November 2017: Current Urology
https://www.readbyqxmd.com/read/29221688/primary-tumor-location-and-survival-in-the-general-population-with-metastatic-colorectal-cancer
#13
Shahid Ahmed, Punam Pahwa, Duc Le, Haji Chalchal, Selliah Chandra-Kanthan, Nayyer Iqbal, Anthony Fields
BACKGROUND: Recent evidence from clinical trials suggests that primary tumor location in patients with metastatic colorectal cancer correlates with differential outcomes, and patients with tumors originating in the right side of the colon have inferior survival. We conducted a large population-based cohort study using individual patient data to confirm the prognostic importance of primary tumor location in the general population with metastatic colorectal cancer. METHODS: A cohort of 1947 patients who were diagnosed with metastatic colorectal cancer from 1992 to 2010 was studied...
November 21, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29221354/dr-masaki-hashimoto-clinical-impact-of-circulating-tumor-cell-in-metastatic-colorectal-cancer-patients-who-underwent-pulmonary-metastasectomy
#14
Qiuyuan Li
No abstract text is available yet for this article.
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29204700/the-immunoscore-system-predicts-prognosis-after-liver-metastasectomy-in-colorectal-cancer-liver-metastases
#15
Yun Wang, Hao-Cheng Lin, Ma-Yan Huang, Qiong Shao, Zhi-Qiang Wang, Feng-Hua Wang, Yun-Fei Yuan, Bin-Kui Li, De-Shen Wang, Pei-Rong Ding, Gong Chen, Xiao-Jun Wu, Zhen-Hai Lu, Li-Ren Li, Zhi-Zhong Pan, Peng Sun, Shu-Mei Yan, De-Sen Wan, Rui-Hua Xu, Yu-Hong Li
BACKGROUND: The Immunoscore was initially established to evaluate the prognosis of stage I/II/III colorectal cancer patients. However, the feasibility of the Immunoscore for the prognosis of colorectal cancer liver metastases (CRCLM) has not been reported. METHODS: Liver metastases in 249 CRCLM patients were retrospectively analyzed. The Immunoscore was assessed according to the counts and densities of CD3+ and CD8+ T cells in the central- and peritumoral areas by immunohistochemistry...
December 4, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29199665/metastasectomy-for-recurrent-or-metastatic-biliary-tract-cancers-a-single-center-experience
#16
I Park, Y S Kim, S J Sym, H K Ahn, K K Kim, Y H Park, J N Lee, D B Shin
PURPOSE: To assess efficacy or long-term result of metastasectomy for recurrent or metastatic biliary tract carcinoma (BTC), we conducted a retrospective review of the outcomes of metastasectomy for recurrent or metastatic BTCs, comprising intrahepatic cholangiocellular carcinoma (IHCCC), proximal and distal common bile duct cancer (pCBDC and dCBDC), gallbladder cancer (GBC), and ampulla of Vater cancer (AoVC). PATIENTS AND METHODS: The clinicopathological features and outcomes of BTC patients who underwent surgical resection for the primary and metastatic disease at the Gachon University Gil Medical Centre from 2003 to 2013 were reviewed retrospectively...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29199651/is-pulmonary-metastasectomy-beneficial-in-head-and-neck-squamous-cell-carcinoma-a-review-of-literature
#17
REVIEW
N R Subramaniam, R Reddy, D Balasubramanian, K Thankappan, S Iyer
Metastatic head and neck squamous cell carcinoma (HNSCC) has traditionally carried a dismal prognosis; however with advances in care, it has been shown that pulmonary metastasectomy is a viable therapeutic option in selected patients, palliating symptoms and improving survival. With the increasing incidence of human papilloma virus-related HNSCC and better availability of minimal access surgery, there is a need to better understand the role of pulmonary metastasectomy in the treatment of HNSCC. This article summarizes the literature on indications, results, surgical options and approaches, clinical dilemmas, and controversies associated with pulmonary metastasectomy in HNSCC, to identify suitable candidates and optimize outcomes...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29188500/metastasectomy-for-tumor-infiltrating-lymphocytes-an-emerging-operative-indication-in-surgical-oncology
#18
Joseph G Crompton, Nicholas Klemen, Udai S Kammula
Adoptive cell transfer (ACT) of tumor-infiltrating lymphocytes (TILs) is an emerging immunotherapy for metastatic cancer. Surgeons play a central role in ACT treatments by performing resection of tumors from which TILs are isolated. It is important that surgeons have familiarity with this emerging treatment method because it is increasingly performed for an expanding variety of solid tumors at institutions around the world. This report offers a brief introduction to ACT for cancer, highlights historical milestones in its development, and provides patient selection and operative considerations for surgeons called upon to perform metastasectomy for the purpose of isolating TILs...
November 29, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29180897/prognostic-value-of-site-specific-metastases-and-therapeutic-roles-of-surgery-for-patients-with-metastatic-bladder-cancer-a-population-based-study
#19
Fan Dong, Yifan Shen, Fengbin Gao, Tianyuan Xu, Xianjin Wang, Xiaohua Zhang, Shan Zhong, Minguang Zhang, Shanwen Chen, Zhoujun Shen
Background: We aimed to evaluate the prognostic value of site-specific metastases in patients with metastatic bladder cancer and analyze the roles that surgeries play in the treatment of this malignancy. Materials and methods: A population-based retrospective study using Surveillance, Epidemiology and End Results dataset was performed and metastatic bladder cancer patients were classified according to the sites of metastases (bone, brain, liver, lung and distant lymph nodes)...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29177194/primary-upper-urinary-tract-small-cell-carcinoma-a-case-series-and-literature-review
#20
Patrick J Hensley, Amul A Bhalodi, Shubham Gupta
Background: Primary upper urinary tract small cell carcinoma (SCC) is exceedingly rare with < 30 cases reported in the literature. Little is known about the incidence, diagnosis, treatment, and outcomes in these patients. We present a series of three patients with primary upper tract SCC. Case Presentation: Patient 1 is an 89-year-old Caucasian male who presented with hydroureteronephrosis and a mass in the proximal right ureter. Biopsy revealed SCC. Without further intervention, the patient died 2 months after his diagnosis...
2017: Journal of Endourology Case Reports
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