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https://www.readbyqxmd.com/read/28932634/pd1-positive-tumor-infiltrating-lymphocytes-are-associated-with-poor-clinical-outcome-after-pulmonary-metastasectomy-for-colorectal-cancer
#1
Dagmar Kollmann, Thomas Schweiger, Stefan Schwarz, Desislava Ignatova, Yun-Tsan Chang, Gerrit Lewik, Sebastian F Schoppmann, Wolfram Hoetzenecker, Walter Klepetko, Emmanuella Guenova, Konrad Hoetzenecker
Pulmonary metastasectomy (PM) is routinely performed in colorectal cancer (CRC) patients with oligometastatic spreading to the lungs. Patients with an aggressive tumor phenotype should be excluded from PM, since its benefit is outweighed by early tumor recurrence and impaired prognosis. Expression of PD-1 and its ligands are prognostic factors in a variety of primary tumors. However, their impact on patients' outcome in the setting of PM for CRC has not been evaluated before. 53 CRC patients with pulmonary metastases receiving PM with curative intent were included in this study...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28932626/complete-biochemical-response-after-pulmonary-metastasectomy-in-prostate-adenocarcinoma
#2
Jonathan Rush, Reet Pai, Rahul A Parikh
BACKGROUND: Prostate cancer most commonly metastasizes to bones or lymph nodes, and metastatic prostate cancer is suggestive of disseminated disease. Metastatic disease is usually not amenable to surgery. CASE PRESENTATION: The current report presents a unique case of in which the excision of a solitary pulmonary metastasis resulted in undetectable prostate-specific antigen. CONCLUSION: This case and others suggest metastasectomy could be considered in cases with solitary metastasis, and physicians should have a careful discussion regarding risks and possible benefits from surgical excision...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/28927977/the-role-of-pulmonary-metastasectomy-for-hepatoblastoma-in-children-with-metastasis-at-diagnosis-results-from-the-jplt-2-study
#3
Tomoro Hishiki, Kenichiro Watanabe, Kohmei Ida, Ken Hoshino, Tomoko Iehara, Yuki Aoki, Takuro Kazama, Kentaro Kihira, Yuichi Takama, Tomoaki Taguchi, Junya Fujimura, Shohei Honda, Kimikazu Matsumoto, Makiko Mori, Michihiro Yano, Akiko Yokoi, Yukichi Tanaka, Hiroshi Fuji, Osamu Miyazaki, Kenichi Yoshimura, Tetsuya Takimoto, Eiso Hiyama
BACKGROUND/PURPOSE: The purpose of this study was to clarify the role of pulmonary metastasectomy in hepatoblastomas with lung metastasis at diagnosis. We reviewed cases enrolled in the JPLT-2 study. METHODS: A total of 360 cases with hepatoblastoma were enrolled. The clinical courses and outcome of 60 cases with pulmonary metastasis at diagnosis were reviewed, focusing on metastasectomy. RESULTS: Induction chemotherapy resulted in eradication of nodules in 26, residual nodules in 33, and early treatment-related death in one...
September 4, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28917254/stereotactic-radiotherapy-in-oligometastatic-cancer
#4
Thomas A C Kennedy, Mark T Corkum, Alexander V Louie
Oligometastatic cancer describes a disease state somewhere between localized and metastatic cancer. Proposed definitions of oligometastatic disease have typically used a cut-off of five or fewer sites of disease. Treatment of oligometastatic disease should have the goal of long-term local control, and in selected cases, disease remission. While several retrospective cohorts argue for surgical excision of limited metastases (metastasectomy) as the preferred treatment option for several clinical indications, limited randomized data exists for treating oligometastases...
September 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/28904173/impact-of-metastasectomy-in-the-multimodality-approach-for-braf-v600e-metastatic-colorectal-cancer-the-mayo-clinic-experience
#5
Benny Johnson, Zhaohui Jin, Mark J Truty, Rory L Smoot, David M Nagorney, Michael L Kendrick, Benjamin R Kipp, Axel Grothey
BACKGROUND: BRAF V600E mutations are present in 8%-10% of patients with metastatic colorectal cancer (mCRC) and portend poor prognosis. This study investigated the impact of metastasectomy for patients with BRAF V600E mCRC. Subjects, Materials, and Methods . Using prospective clinical and molecular data, patients with BRAF V600E mCRC were analyzed for clinical characteristics and survival. Statistical analyses utilized the Kaplan-Meier method, log-rank test, and Cox proportional hazard models...
September 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28892430/characterization-of-pulmonary-metastases-in-children-with-hepatoblastoma-treated-on-children-s-oncology-group-protocol-ahep0731-the-treatment-of-children-with-all-stages-of-hepatoblastoma-a-report-from-the-children-s-oncology-group
#6
Allison F O'Neill, Alexander J Towbin, Mark D Krailo, Caihong Xia, Yun Gao, M Beth McCarville, Rebecka L Meyers, Eugene D McGahren, Greg M Tiao, Stephen P Dunn, Max R Langham, Christopher B Weldon, Milton J Finegold, Sarangarajan Ranganathan, Wayne L Furman, Marcio Malogolowkin, Carlos Rodriguez-Galindo, Howard M Katzenstein
Purpose To determine whether the pattern of lung nodules in children with metastatic hepatoblastoma (HB) correlates with outcome. Methods Thirty-two patients with metastatic HB were enrolled on Children's Oncology Group Protocol AHEP0731 and treated with vincristine and irinotecan (VI). Responders to VI received two additional cycles of VI intermixed with six cycles of cisplatin/fluorouracil/vincristine/doxorubicin (C5VD), and nonresponders received six cycles of C5VD alone. Patients were imaged after every two cycles and at the conclusion of therapy...
September 11, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28890815/the-role-of-neoadjuvant-radiotherapy-for-locally-advanced-rectal-cancer-with-resectable-synchronous-metastasis
#7
Croix C Fossum, Jasim Y Alabbad, Lindsay B Romak, Christopher L Hallemeier, Michael G Haddock, Marianne Huebner, Eric J Dozois, David W Larson
BACKGROUND: Although neoadjuvant radiotherapy is typically administered for locally-advanced rectal cancer to reduce local recurrence (LR), its role for patients who present with synchronous resectable liver and/or lung metastasis is not well defined. The aim of this study was to evaluate the role of neoadjuvant radiotherapy for patients with stage IV rectal cancer undergoing curative-intent surgery. METHODS: This study is a retrospective review of a prospectively maintained surgical registry of all consecutive adult patients who underwent curative-intent resection at Mayo Clinic in Rochester, MN, from January 1990 until December 2014 with a median follow-up time of 43 (IQR 16-67) months...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28884044/survival-after-pulmonary-metastasectomy-in-colorectal-cancer-patients-does-a-history-of-resected-liver-metastases-worsen-the-prognosis-a-literature-review
#8
Jon Zabaleta, Borja Aguinagalde, Iker Lopez, Arantza Fernandez-Monge, Jose M Izquierdo, Jose I Emparanza
OBJECTIVE: : To assess the impact of past liver metastases on the survival duration of patients who are undergoing surgery for lung metastases. METHODS: : We conducted a review of literature published from 2007 to 2014. The studies were identified by searching PubMed, MEDLINE, and Embase and were supplemented by a manual search of the references listed by the retrieved studies. The following search terms were used: lung metastasectomy, pulmonary metastasectomy, lung metastases, and lung metastasis...
August 2017: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/28877449/surgical-management-of-metastatic-renal-cell-carcinoma
#9
Mark W Ball
Despite advances in systemic therapy for metastatic renal cell carcinoma, durable responses remain rare and surgical management remains a mainstay of treatment for many patients with metastatic disease. Management of the primary tumor in metastatic patients can occur as 1) palliative nephrectomy for symptomatic patients in whom cure is not achievable, 2) cytoreductive nephrectomy before systemic therapy, or 3) consolidative nephrectomy after systemic therapy. Palliative nephrectomy is rarely performed in centers where angioembolization is available...
June 2017: Discovery Medicine
https://www.readbyqxmd.com/read/28863862/imaging-strategy-and-outcome-following-partial-nephrectomy
#10
Pascal Mouracade, Jaya S Chavali, Onder Kara, Julien Dagenais, Matthew J Maurice, Ryan J Nelson, Brian I Rini, Jihad H Kaouk
OBJECTIVES: The aim of this study was to analyze the outcomes of surveillance after partial nephrectomy (PN) in a single institution and the relevance of imaging studies in detecting recurrence. MATERIAL AND METHODS: Retrospective study of 830 patients who underwent PN for localized renal cell carcinoma between 2007 and 2015 at a single institution. We studied the characteristics of recurrence according to pathological and clinical features and elaborated risk groups...
August 29, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28849376/surgical-outcomes-of-isolated-malignant-pulmonary-nodules-in-patients-with-a-history-of-breast-cancer
#11
Zuodong Song, Ting Ye, Longfei Ma, Jiaqing Xiang, Haiquan Chen
BACKGROUND: The role of surgery for isolated malignant pulmonary nodules in breast cancer patients remains unclear. METHODS: A total of 1286 consecutive breast cancer patients with pulmonary nodules detected by thoracic computed tomography (CT) or positron emission tomography (PET)/CT scan at Shanghai Cancer Center, Fudan University, were reviewed. Overall, 147 breast cancer patients with isolated malignant pulmonary nodules receiving surgery and/or chemotherapy were enrolled in the study...
August 28, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28848704/intimal-sarcoma-of-the-pulmonary-artery-with-multiple-lung-metastases-long-term-survival-case
#12
Sonia García-Cabezas, Macarena Centeno-Haro, Simona Espejo-Pérez, Elvira Carmona-Asenjo, Alberto L Moreno-Vega, Rosa Ortega-Salas, Amalia Palacios-Eito
Pulmonary artery intimal sarcoma (PAIS) is a rare tumor with a very poor prognosis. Clinical and radiological findings usually mimic thromboembolic disease, leading to diagnostic delays. The treatment of choice is surgery, and adjuvant chemotherapy and radiotherapy have limited results. We report the case of a 48-year-old male patient, initially suspected with pulmonary thromboembolism. The angio-CT revealed a filling defect in the pulmonary artery trunk. The patient underwent surgery, resulting in with complete resection of the mass with a diagnosis of PAIS...
August 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28834880/metastatic-spread-of-solid-subtype-lung-adenocarcinoma-to-the-small-intestine-with-anemia-and-melena-a-case-report
#13
Xiaofang Ying, Mingwei Wang, Vivek Verma, Manxiang Wang, Shengwei Ye, Jianping Bi, Xiaoyi Zhou, Guang Han, Weining Zhen
RATIONALE: Metastasis to the small intestine from a primary lung cancer is rare, and is associated with a poor prognosis. Early diagnosis of small intestine metastasis is difficult because of the low incidence of clinically apparent symptoms. PATIENT CONCERNS: Clinical data and treatment of a 59-year-old man with small intestine metastasis from primary solid subtype lung adenocarcinoma are summarized. DIAGNOSES: A man who was previously diagnosed with stage IIIA (T3N2M0) lung adenocarcinoma (solid subtype) came to our hospital for postoperative radiotherapy...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28832177/the-chest-wall-tumor-as-a-rare-clinical-presentation-of-hepatocellular-carcinoma-metastasis
#14
S Porsok, M Mego, D Pinďák, R Duchoň, J Beniak, J Mardiak
BACKGROUND: Extrahepatic metastatic spread of hepatocellular carcinoma is present at the time of diagnosis in 5-15% of hepatocellular carcinoma patients. The most common site of metastastic spread is the lungs, bones, lymph nodes. Isolated chest wall localization is extremely rare. CASE: We report a 58-year-old patient with large, synchronous chest wall hepatocellular carcinoma metastasis with solitary primary hepatocellular carcinoma. He underwent a radical, surgical en bloc metastasectomy and subsequent anatomic liver resection...
2017: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/28778197/outcome-after-resection-of-adrenocortical-carcinoma-liver-metastases-a-retrospective-study
#15
Johannes Baur, Tjark-Ole Büntemeyer, Felix Megerle, Timo Deutschbein, Christine Spitzweg, Marcus Quinkler, Peter Nawroth, Matthias Kroiss, Christoph-Thomas Germer, Martin Fassnacht, Ulrich Steger
BACKGROUND: Metastatic Adrenocortical Carcinoma (ACC) is a rare malignancy with a poor 5-year-survival rate (<15%). A surgical approach is recommended in selected patients if complete resection of distant metastasis can be achieved. To date there are only limited data on the outcome after surgical resection of hepatic metastases of ACC. METHODS: A retrospective analysis of the German Adrenocortical Carcinoma Registry was conducted. Patients with liver metastases of ACC but without extrahepatic metastases or incomplete tumour resection were included...
August 4, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28769127/lung-metastasectomy-for-pulmonary-metastatic-breast-carcinoma
#16
Sascha Macherey, Peter Mallmann, Wolfram Malter, Fabian Doerr, Matthias Heldwein, Thorsten Wahlers, Khosro Hekmat
Breast carcinoma with pulmonary metastasis can be treated locally or systemically. Following primary tumour resection patients with isolated, completely resectable pulmonary nodules and definite functional operability can be offered lung metastasis resection. Following metastasectomy a median survival of 32 to 96.6 months can be achieved with corresponding five-year survival rates between 30.8 and 54.4%. The procedure is associated with a mortality rate of 0 to 3%. The most important independent prognostic factor for long-term survival is complete resection of all lung lesions...
June 2017: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/28768676/role-of-metastasectomy-and-chemotherapy-in-carcinoma-of-uterine-cervix
#17
Nasir Ali, Muhammad Atif Mansha, Ahmed Nadeem Abbasi, Bilal Mazhar Qureshi
Squamous cell carcinoma of uterine cervix is potentially a curable disease; however, many patients treated with definitive chemoradiotherapy develop distant metastases, with few of them having a single metastatic deposit. There are no guidelines for the treatment of patients with oligometastatic cervical cancer.We present a case of a patient with International Federation of Gynecology and Obstetrics (FIGO) Stage IIB squamous cell carcinoma of uterine cervix. She was successfully treated with concurrent chemoradiotherapy with definitive intent...
August 2, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28768424/surgical-salvage-of-recurrence-after-resection-of-colorectal-liver-metastases-incidence-and-outcomes
#18
Nuh N Rahbari, Michael I D'Angelica
Surgical resection remains the primary curative treatment option for patients with colorectal liver metastases. While the majority of patients will develop tumor relapse within or outside of the liver after hepatic metastasectomy, a subset of these patients may be amenable to salvage surgical resection. However, outcomes for this approach are not well defined. In this article, we summarize the current evidence for the incidence, feasibility and outcomes of salvage resection for recurrence after initial resection of colorectal liver metastases...
August 3, 2017: Epigenomics
https://www.readbyqxmd.com/read/28736252/systemic-therapy-following-metastasectomy-for-renal-cell-carcinoma-using-insights-from-other-clinical-settings-to-address-unanswered-questions
#19
REVIEW
Leonard J Appleman, Jodi K Maranchie
Surgical resection for metastatic renal cell carcinoma (RCC) was first described several decades ago, but the appropriate role for surgery in coordinated multidisciplinary care has not been well-defined. The explosive development of new therapies for advanced RCC over the past 10 years has improved the outlook for patients, and there is now renewed interest in surgical metastasectomy for selected patients with metastatic RCC, moving away from the conventional dichotomy between surgery for local disease and systemic therapy for metastatic disease...
July 20, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28723487/clinical-case-discussion-isolated-lung-metastases-after-radical-nephrectomy-for-clear-cell-carcinoma-the-case-for-surgery
#20
Axel S Merseburger, Emanuel Palade
In a stable patient with metastatic renal cell carcinoma, metastasectomy is an option when all the lesions can be resected. Individual informed consent from the patient is most important.
December 15, 2016: European Urology Focus
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