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Gehad Ahmed, Manal Zamzam, Ahmed Kamel, Sonia Ahmed, Asmaa Salama, Iman Zaki, Nehal Kamal, Maged Elshafiey
BACKGROUND: Complete metastasectomy is the best predictor of survival in patients with osteosarcoma pulmonary metastases. There has been some controversy in the literature regarding the prognostic significance of the timing of occurrence of lung metastasis. METHODS: We reviewed the clinical course of all osteosarcoma patients with pulmonary metastases treated by metastasectomy in our hospital from January 2008 through December 2016. Each patient who underwent metastasectomy was placed into one of three groups based on whether lung metastases were present at initial presentation (Group 1), developed during chemotherapy (Group 2), or appeared after completion of chemotherapy (Group 3)...
June 23, 2018: Journal of Pediatric Surgery
Yongjiang Li, Wenbiao Zhang, Shuangjiang Li, Chongqi Tu
Introduction: Recurrent pulmonary metastasis is common in sarcoma patients following the first pulmonary metastasectomy. Repeated pulmonary metastasectomy (RPM) may be a possible treatment method, but it has several unfavorable aspects. The clinical efficiency of RPM has not been established, as previous studies have reached inconsistent results. Materials and Methods: Comprehensively literature searches were conducted in PubMed, Web of Science, Embase, and Cochrane Library...
June 2018: Journal of Cancer Research and Therapeutics
Chaturbhuj Ramanand Agrawal, Kumardeep Dutta, Dinesh Chandra Doval, Sunil Pasricha, Manoj Gupta
Primary malignancies of the salivary gland itself are uncommon, while secondary metastatic deposits are further very rare with description of only few case reports in the literature. The most common site of metastatic deposit to parotid gland is from squamous cell malignancies of head and neck, while secondary deposits from primary in infraclavicular location are very rarely described. We herein describe the case of an elderly lady who while on adjuvant endocrine therapy developed metastatic disease with right intraparotid node as the sole site of metastasis detected on FDG PET scan...
July 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
Simone Wigge, Klaus Heißner, Volker Steger, Ruth Ladurner, Frank Traub, Bence Sipos, Hans Bösmüller, Lothar Kanz, Frank Mayer, Hans-Georg Kopp
BACKGROUND AND OBJECTIVES: The role of local surgical procedures in patients with metastatic soft tissue sarcoma is still undefined. Few retrospective studies have reported survival benefits for patients with pulmonary metastases after complete surgical resection. Treatment decisions are therefore mainly based on personal experiences rather than on reproducible knowledge. METHOD: A total of 237 patients with metastatic sarcoma, treated between 1982 and 2015 at the University Hospital Tuebingen, Germany, were eligible for inclusion...
June 28, 2018: Journal of Surgical Oncology
Minyong Kang, Jae Young Park, Chang Wook Jeong, Eu Chang Hwang, Cheryn Song, Sung-Hoo Hong, Cheol Kwak, Jinsoo Chung, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Se Hoon Park, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Seong Il Seo
PURPOSE: This study aimed to evaluate conditional survival (CS) probabilities in patients with metastatic renal cell carcinoma (mRCC) who undergo first-line tyrosine kinase inhibitor (TKI) therapy and identify the predictors for CS over time. MATERIALS AND METHODS: We retrospectively reviewed clinical data of 1,659 individuals with mRCC from the Korean Renal Cancer Study Group database, among which 1,131 were finally analyzed. The primary endpoint was conditional overall survival (OS)...
June 22, 2018: Journal of Urology
Satoru Okada, Kyoko Itoh, Shunta Ishihara, Junichi Shimada, Daishiro Kato, Hiroaki Tsunezuka, Naoko Miyata, Shigeru Hirano, Satoshi Teramukai, Masayoshi Inoue
BACKGROUND: The mechanism by which tumors escape the immune system has been actively investigated and is partly explained by the programmed death-1 (PD-1) and its ligand (PD-L1) pathway. This study is aimed at clarifying the prognostic significance of PD-L1 expression in patients with surgically resected pulmonary metastases of head and neck squamous cell carcinoma (HNSCC). PATIENTS AND METHODS: A retrospective review was conducted of 26 HNSCC patients who underwent complete resection of pulmonary metastases...
June 2018: Surgical Oncology
Maxine Sun, Christian P Meyer, Jose A Karam, Guillermo de Velasco, Steven L Chang, Sumanta K Pal, Quoc-Dien Trinh, Toni K Choueiri
INTRODUCTION: Metastasectomy (MSX) is considered a treatment option in patients with metastatic renal cell carcinoma (mRCC) at diagnosis, but its role in the targeted therapy era is unclear. We sought to describe the utilization trends of MSX and survival outcomes in a large US cohort. MATERIALS AND METHODS: Using the National Cancer Database, we identified patients undergoing MSX for mRCC at diagnosis between 2006 and 2013. Linear regression methods estimated utilization trends, and hierarchical models identified independent predictors of MSX after adjusting for hospital clustering...
June 5, 2018: European Journal of Surgical Oncology
Kartikeya Rajdev, Abdul Hasan Siddiqui, Shivika Agarwal, Yusra Ansari, Rabih Maroun
Colorectal carcinoma is one of the most common and significant causes of cancer-related death. Metastasis to mediastinal lymph nodes and/or pleura without liver or lung involvement is an atypical pattern of colon cancer metastasis. A 70-year-old male underwent curative right side hemicolectomy and omentectomy for ascending colon cancer followed by adjuvant chemotherapy. Around nine months after surgery, the patient was noted to have bilateral large pleural effusions on the restaging computed tomography scan of the chest/abdomen/pelvis...
January 1, 2018: Journal of Oncology Pharmacy Practice
Dakui Luo, Qi Liu, Wencheng Yu, Yanlei Ma, Ji Zhu, Peng Lian, Sanjun Cai, Qingguo Li, Xinxiang Li
PURPOSE: We investigated the prognostic value of distant metastasis sites among patients with metastatic colorectal cancer (CRC) and the significance of metastasectomy and resection of the primary CRC. METHODS: Between 2010 and 2014, patients diagnosed with metastatic colorectal adenocarcinoma were selected using the surveillance, epidemiology, and end results (SEER) database. The prognosis of these patients was compared according to the site of metastasis (liver, lung, bone, and brain)...
June 21, 2018: International Journal of Colorectal Disease
Yohei Yamada, Ken Hoshino, Teisaburo Mori, Miho Kawaida, Kiyotomo Abe, Nobuhiro Takahashi, Takumi Fujimura, Kaori Kameyama, Tatsuo Kuroda
BACKGROUND: The curability of hepatoblastoma (HB) largely depends on the achievement of radical surgical resection, even for metastatic tumors. However, the extension of the metastatic tumor when viewed through an endoscope with the conventional white-light mode is often unclear. Advancements in imaging technology utilizing indocyanine green (ICG) have facilitated precise resection of metastatic HBs, owing to the longer retention of ICG in such lesions than in other normal tissues. CASE: We utilized an endoscope loaded with the PINPOINT system (NOVADAQ Technologies, Inc...
June 15, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
Christopher Abraham, Adam Garsa, Shahed N Badiyan, Robert Drzymala, Deshan Yang, Todd DeWees, Christina Tsien, Joshua L Dowling, Keith M Rich, Michael R Chicoine, Albert H Kim, Eric C Leuthardt, Cliff Robinson
Objective: To identify potentially actionable dosimetric predictors of local control (LC) for non-small cell lung cancer (NSCLC) brain metastases treated with single-fraction stereotactic radiosurgery (SRS). Methods and materials: Patients with NSCLC brain metastases treated with single-fraction SRS were identified. Eligible patients had at least 1 follow-up magnetic resonance imaging scan and were without prior metastasectomy or SRS to the same lesion. LC and overall survival (OS) were estimated using the Kaplan-Meier method...
April 2018: Advances in Radiation Oncology
Matthieu Zellweger, Etienne Abdelnour-Berchtold, Thorsten Krueger, Hans-Beat Ris, Jean Yannis Perentes, Michel Gonzalez
Colorectal cancer (CRC) is a frequently occurring disease, yet diagnosed at a local stage in only 40% of cases. Lung metastases (LM) appear in 5-15% of patients and, left untreated, carry a very poor prognosis. Some CRC patients may benefit from a potentially curative LM resection, but success and benefit are difficult to predict. We discuss prognostic factors of survival after lung metastasectomy in CRC patients under several scenarios (with/ without prior liver metastases; repetitive pulmonary resections)...
July 2018: Critical Reviews in Oncology/hematology
Uyen-Thao Le, Peter Bronsert, Francesco Picardo, Sabine Riethdorf, Benedikt Haager, Bartosz Rylski, Martin Czerny, Friedhelm Beyersdorf, Sebastian Wiesemann, Klaus Pantel, Bernward Passlick, Jussuf Thomas Kaifi, Severin Schmid
Circulating tumor cells (CTC) have been studied extensively in various tumor types and are a well-established prognosticator in colorectal cancer (CRC). This is the first study to isolate CTC directly from the tumor outflow in secondary lung tumors. For this purpose in 24 patients with CRC who underwent pulmonary metastasectomy in curative intent blood was drawn intraoperatively from the pulmonary vein (tumor outflow). In 22 samples CTC-enumeration was performed using CellSieve-microfilters and immunohistochemical- and Giemsa-staining...
June 8, 2018: Scientific Reports
Qian-Kun Xie, Wen-Zhuo He, Wan-Ming Hu, Lin Yang, Chang Jiang, Peng-Fei Kong, Yuan-Zhong Yang, Qiong Yang, Hui-Zhong Zhang, Bei Zhang, Liang-Ping Xia
Background: Although tumor-infiltrating lymphocytes (TILs) have been understood for years as a favorable prognostic factor for colorectal cancers (CRCs) after complete surgical resection, its prognostic role in metastatic CRC (mCRC) remains poorly defined, and it is largely unknown how this prognostic benefit relates to the metastatic status and operation modality. Materials and methods: After reviewing 2215 consecutive cases of surgically resected CRC, 332 patients newly diagnosed with stage IV CRC and treated at the Sun Yat-Sen University Cancer Center between 2009 and 2014 were included...
2018: Cancer Management and Research
Francesco Montagnani, Francesca Crivelli, Giuseppe Aprile, Caterina Vivaldi, Irene Pecora, Rocco De Vivo, Mario Alberto Clerico, Lorenzo Fornaro
BACKGROUND: Despite the amelioration of systemic therapy, overall survival (OS) of metastatic gastric cancer (GC) patients remains poor. Liver is a common metastatic site and retrospective series suggest a potential OS benefit from hepatectomy, with interesting 5-year (5 y) and 10-year (10 y) OS rates in selected patients. We aim to evaluate the impact of liver resection and related prognostic factors on long-term outcome in this setting. METHODS: We searched Pubmed, EMBASE, and Abstracts/posters from international meetings since 1990...
May 17, 2018: Cancer Treatment Reviews
Kamran Ali, Sukki Cho, Hyo Jun Jang, Kwhanmien Kim, Sanghoon Jheon
BACKGROUND:  The aim of this study was to identify the factors predicting thoracic lymph node (LN) metastases for pulmonary resection from colorectal cancer (CRC). METHODS:  The records of 160 patients who underwent pulmonary metastasectomy for CRC were retrospectively reviewed. Clinicopathologic factors were analyzed with chi-square test or t -test and logistic regression to identify predictable factors for LN metastases. RESULTS:  Sixty patients (37...
May 29, 2018: Thoracic and Cardiovascular Surgeon
Maciej Nowacki, Dariusz Grzanka, Wojciech Zegarski
We report the first application of pressurized intraperitoneal aerosol chemotherapy (PIPAC) as a rescue therapy before palliative D2 gastrectomy combined with liver metastasectomy performed in a 49-year-old woman with peritoneal carcinomatosis who was primarily diagnosed with and underwent surgery for a Krukenberg tumor. The PIPAC procedure was performed with the use of cisplatin at 7.5 mg/m2 and doxorubicin at 1.5 mg/m2 for 30 min at 37 °C. Eight weeks after the PIPAC procedure, the patient underwent open classic D2 gastrectomy with the creation of a Roux-en-Y anastomosis (RNY) combined with liver metastasectomy...
May 21, 2018: World Journal of Gastroenterology: WJG
Stéphane Renaud, Joseph Seitlinger, Yaseen Al Lawati, Francesco Guerrera, Pierre-Emmanuel Falcoz, Gilbert Massard, Lorenzo Ferri, Jonathan Spicer
OBJECTIVE: The aim of this study was to evaluate the benefit of anatomical resection (AR) in lung metastasectomy (LM) of colorectal cancer (CRC) harboring KRAS mutations SUMMARY BACKGROUND DATA:: KRAS mutations are related to high aggressiveness in the lung metastasis of CRC. It is unknown whether AR can lead to better outcomes than can non-AR (NAR) in KRAS patients. METHODS: We retrospectively reviewed the data from 574 consecutive patients who underwent a LM for CRC...
May 17, 2018: Annals of Surgery
William E Gibson, Raul S Gonzalez, Justin M M Cates, Eric Liu, Chanjuan Shi
Pathologic examination of hepatic metastasectomies from patients with metastatic small intestinal or pancreatic neuroendocrine tumor frequently reveals micrometastases undetectable by radiologic or macroscopic gross examination. This finding raises the possibility that undetectable micrometastases remain in these patients after metastasectomy. Here we examined liver resections for micrometastases and assessed their impact on prognosis. Hepatic metastasectomies from 65 patients with neuroendocrine tumor of the small intestine (N=43) or pancreas (N=22) were reviewed for the presence of micrometastases, which were defined as microscopic tumor foci ≤1mm in greatest dimension...
May 12, 2018: Human Pathology
Minyong Kang, Jiwoong Yu, Hyun Hwan Sung, Hwang Gyun Jeon, Byong Chang Jeong, Se Hoon Park, Seong Soo Jeon, Hyun Moo Lee, Han Yong Choi, Seong Il Seo
OBJECTIVES: To examine the prognostic role of the pretreatment aspartate transaminase/alanine transaminase or De Ritis ratio in patients with metastatic renal cell carcinoma receiving first-line systemic tyrosine kinase inhibitor therapy. METHODS: We retrospectively searched the medical records of 579 patients with metastatic renal cell carcinoma who visited Samsung Medical Center, Seoul, Korea, from January 2001 through August 2016. After excluding 210 patients, we analyzed 360 patients who received first-line tyrosine kinase inhibitor therapy...
June 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
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