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https://www.readbyqxmd.com/read/28052606/optn-srtr-2015-annual-data-report-pancreas
#1
R Kandaswamy, P G Stock, S K Gustafson, M A Skeans, M A Curry, M A Prentice, A K Israni, J J Snyder, B L Kasiske
The number of pancreas transplants performed in the United States stabilized over the last 3 years after nearly a decade of steady decline. Numbers of new additions to the list also stabilized during the same period. Notably, the persistent decline in pancreas after kidney transplants also seems to have abated, at least for now. The first full year of data after implementation of the new pancreas allocation system revealed no change in the distribution of organs between simultaneous pancreas-kidney (SPK) transplant and pancreas transplant alone...
January 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28034588/abo-blood-group-and-prevalence-of-osteoporosis-and-osteopenia-in-the-elderly-population-an-amirkola-health-and-ageing-project-ahap-based-study
#2
Nayer Seyfizadeh, Narges Seyfizadeh, Hajar Negahdar, Seyed Reza Hosseini, Hajighorban Nooreddini, Hadi Parsian
Osteoporosis is known as a degenerative disease of the skeletal system and its main complication is fracture, which influences quality of life in the elderly. There are 4 major blood groups in humans based on the presence of A and B antigens. According to the investigations, there are reported relations between blood types and some diseases. In this study, the association between the ABO blood group and the prevalence of osteoporosis and osteopenia in an elderly population was investigated. Medical records of 990 elderly people were investigated in a cross-sectional study and the association between their blood group and the incidence of osteoporosis and osteopenia was analyzed using SPSS version 17...
December 26, 2016: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/28031957/the-role-of-the-histoblood-abo-group-in-cancer
#3
REVIEW
Seth K Rummel, Rachel E Ellsworth
Since the first link between blood type and cancer was described in 1953, numerous studies have sought to determine whether the histoblood ABO group is associated with tumorigenesis. In 2009, the first significant association between a SNP located within the ABO glycosyltransferase gene and increased risk of pancreatic cancer was reported. Here, we describe the history and possible functions of the histoblood ABO group and then provide evidence for a role of blood group antigens in the most common cancer types worldwide using both blood type and SNP data...
June 2016: Future Science OA
https://www.readbyqxmd.com/read/28028997/comparative-analysis-of-clinical-samples-showing-weak-serum-reaction-on-autovue-system-causing-abo-blood-typing-discrepancies
#4
Su Yeon Jo, Ju Mi Lee, Hye Lim Kim, Kyeong Hwa Sin, Hyeon Ji Lee, Chulhun Ludgerus Chang, Hyung Hoi Kim
BACKGROUND: ABO blood typing in pre-transfusion testing is a major component of the high workload in blood banks that therefore requires automation. We often experienced discrepant results from an automated system, especially weak serum reactions. We evaluated the discrepant results by the reference manual method to confirm ABO blood typing. METHODS: In total, 13,113 blood samples were tested with the AutoVue system; all samples were run in parallel with the reference manual method according to the laboratory protocol...
March 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28028639/relationship-between-abo-blood-group-and-clinicopathological-factors-and-their-effect-on-the-survival-of-japanese-patients-with-esophageal-squamous-cell-carcinoma
#5
Fumiaki Shiratori, Hideaki Shimada, Satoshi Yajima, Takashi Suzuki, Yoko Oshima, Tatsuki Nanami, Masaaki Ito, Hironori Kaneko
PURPOSE: Several studies have evaluated the association between ABO blood group and the prognosis of various types of cancer; however, little is known about the relationship between ABO blood group and esophageal squamous cell carcinoma (SCC). We investigated how ABO blood group and clinicopathological characteristics are related to the survival of Japanese patients with esophageal SCC. METHODS: We reviewed the medical records of 181 patients who underwent surgery for esophageal SCC between June, 2004 and December, 2015 and analyzed the association between ABO blood group and clinicopathological factors...
December 27, 2016: Surgery Today
https://www.readbyqxmd.com/read/28028403/assessment-of-increase-in-aortic-and-carotid-intimal-medial-thickness-in-type-1-diabetic-patients
#6
Soha M Abd El Dayem, Ahmed A Battah, Abo El Magd El Bohy
AIM: To assess aortic and carotid intima-media thickness (aIMT and cIMT) in diabetic patients. PATIENTS AND METHODS: The study included 75 type 1 diabetic patients and 30 age and sex matched healthy volunteer. A blood sample was taken for analysis of HbA1 and lipid profile and the urine sample was taken for analysis of albumin/creatinine ratio. aIMT and cIMT via ultrasound were also done. RESULTS: cIMT & aIMT were significantly higher in diabetics...
December 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28012709/the-history-and-challenges-of-blood-donor-screening-in-china
#7
REVIEW
Ling Li, Ka Yi Li, Ke Yan, Guojin Ou, Wenhui Li, Jue Wang, Ning Song, Li Tian, Xin Ji, Yongjun Chen, Xiaohua Liang, Zhong Liu, Yanyun Wu
Since the establishment of People's Republic of China in 1949, the Chinese government has encountered several catastrophes related to transfusion transmitted diseases. The government's increasing attention to blood safety has prompted the initiation of a series of policies and measures that have enhanced the level of safety for the blood supply and met the basic clinical demands of blood for 1.3 billion people in the country. Blood donation screening strategies in China predominantly comprise donor screening and donor testing...
November 12, 2016: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/28002655/optimal-dosage-regimen-for-rituximab-in-abo-incompatible-living-donor-liver-transplantation
#8
Hiroto Egawa, Koji Umeshita, Shinji Uemoto
BACKGROUND: Rituximab has greatly improved the outcomes of ABO-incompatible living donor liver transplantation (ABO-I LDLT). To clarify the optimal regimen for rituximab in adult ABO-I LDLT, a multicenter study was conducted in Japan. METHODS: Clinical data of 33 adult patients undergoing ABO-I LDLT at 15 centers in 2013 were retrospectively corrected. RESULTS: The targeted blood type was A1 in 18, B in 14, and AB in 1 patient. Rituximab was administered at 7 to 48 days before LT, at a dose of 375 mg/m(2) in 12 patients, 500 mg in 15 patients, 300 mg in 5 patients, and 100 mg in 1 patient...
December 21, 2016: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/27999143/aspirin-use-and-reduced-risk-of-pancreatic-cancer
#9
Harvey A Risch, Lingeng Lu, Samantha A Streicher, Jing Wang, Wei Zhang, Quanxing Ni, Mark S Kidd, Herbert Yu, Yu-Tang Gao
BACKGROUND: Few options besides the avoidance of smoking and obesity are available to prevent pancreatic cancer. The association between aspirin use and risk of pancreatic cancer has been inconsistent across studies. METHODS: We performed a population-based study of 761 case and 794 control subjects frequency matched on sex and age during 2006 to 2011 in Shanghai, China. Participants were asked about episodes of regular use of aspirin, tablets per day or week, and ages that the use started and stopped...
January 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27988281/distribution-of-abo-blood-groups-and-coronary-artery-calcium
#10
Yao Wang, Bing-Yang Zhou, Cheng-Gang Zhu, Yuan-Lin Guo, Na-Qiong Wu, Ping Qing, Ying Gao, Geng Liu, Qian Dong, Jian-Jun Li
BACKGROUND: ABO blood groups have been confirmed to be associated with cardiovascular diseases such as coronary artery disease. However, whether ABO blood group is correlated with coronary artery calcium (CAC) is still unknown. METHOD: 301 patients with coronary artery calcium score (CACS) assessed by computed tomography were consecutively enrolled and divided into two groups: with calcium group (CACS>0, n=104) and without calcium group (CACS=0, n=197). Distribution of ABO blood groups was evaluated between the two groups...
November 30, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/27984519/the-importance-and-utility-of-hemoglobin-a1c-levels-in-the-assessment-of-donor-pancreas-allografts
#11
Emre Arpali, Joseph R Scalea, Robert R Redfield, Lynn Berg, Dixon Kaufman, Hans W Sollinger, Bridget Welch, Glen Leverson, Jon S Odorico
BACKGROUND: Hemoglobin A1C (HbA1c) levels are often obtained in potential pancreas graft donors to assess the overall long-term functional glycemic control or the possibility of unrecognized diabetes. Although routinely measured, the impact of donor HbA1c levels on pancreas graft outcomes has not been reported. Here, we researched the relationship between donor HbA1c levels and postoperative pancreas graft survival. METHODS: Data from 266 pancreas transplant patients including 182 simultaneous kidney-pancreas and 84 pancreas alone transplants were reviewed for the study...
December 14, 2016: Transplantation
https://www.readbyqxmd.com/read/27979997/glycosyltransfer-in-mutants-of-putative-catalytic-residue-glu303-of-the-human-abo-h-a-and-b-blood-group-glycosyltransferases-gta-and-gtb-proceeds-through-a-labile-active-site
#12
Ryan J Blackler, Susannah M L Gagnon, Robert Polakowski, Natisha L Rose, Ruixiang B Zheng, James A Letts, Asha R Johal, Brock Schuman, Svetlana N Borisova, Monica M Palcic, Stephen V Evans
The homologous glycosyltransferases α-1,3-N-acetylgalactosaminyltransferase (GTA) and α-1,3-galactosyltransferase (GTB) carry out the final synthetic step of the closely related human ABO(H) blood group A and B antigens. The catalytic mechanism of these model retaining enzymes remains under debate, where Glu303 has been suggested to act as a putative nucleophile in a double displacement mechanism, a local dipole stabilizing the intermediate in an orthogonal associative mechanism or a general base to stabilize the reactive oxocarbenium ion-like intermediate in an S N i-like mechanism...
November 22, 2016: Glycobiology
https://www.readbyqxmd.com/read/27977017/effect-of-genetic-variants-of-bilirubin-metabolism-on-the-degree-of-hyperbilirubinemia-in-african-american-newborns
#13
D L Schutzman, L M Baudhuin, E Gatien, S Ajayi, R J Wong
OBJECTIVE: The objective of our study was to measure the effect of genetic variants of these two enzymes, UGT1A1 and SLCO1B1, in the bilirubin metabolic pathway on the degree of hyperbilirubinemia in a cohort of African-American (AA) infants from our well-baby nursery. In addition, a second objective was to document the types and frequencies of genetic variations of these enzymes in our cohort. STUDY DESIGN: A prospective study of 180 AA infants from the Well Baby Nursery of an inner city community hospital, all of whose mothers were type O pos...
December 15, 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27932156/dosing-eculizumab-for-antibody-mediated-rejection-in-kidney-transplantation-a-case-report
#14
B Smith, V Kumar, D Mompoint-Williams, R D Reed, P A MacLennan, K Stegner, J E Locke
Severe antibody-mediated rejection (AMR) of a blood type-incompatible (ABOi) living donor kidney transplantation (LDKT) can lead to graft failure, and aggressive therapies, such as the anticomplement antibody eculizumab, are often used to rescue the affected graft. Eculizumab therapy can be crippling financially. Current literature suggests a wide variation in the amount and timing of eculizumab given as rescue therapy in the setting of AMR. Herein we describe a limited-eculizumab regimen in the setting of severe AMR that is both clinically and cost effective...
November 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27930575/association-between-abo-blood-group-and-hcv-related-hepatocellular-carcinoma-risk-in-china
#15
Xu Li, Hongqin Xu, Zhongyang Ding, Qinglong Jin, Pujun Gao
The ABO blood group has previously been reported to be associated with risk for certain malignancies; however, data about the risks for hepatocellular carcinoma (HCC) according to blood type are limited. Thus, we conducted a retrospective case-control study to investigate whether the ABO blood group contributes to hepatitis C virus (HCV) infection-induced HCC.From January 2010 to June 2016, 447 consecutive patients with chronic HCV infection were recruited. Of these patients, 217 had HCV-related HCC, and 230 had chronic hepatitis C (CHC) without HCC...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27918380/genetic-susceptibility-to-norovirus-gii-4-sydney-strain-infections-in-taiwanese-children
#16
Li-Tzu Tu, Fu-Ping Liu, Yhu-Chering Huang, Chung-Guei Huang, Shuan Yang, Kuo-Chien Tsao, Ming-Wei Lai, Chih-Jung Chen
BACKGROUND: A comprehensive evaluation of associations between the susceptibility to norovirus infections and histo-blood group antigens is not available in the Taiwanese population, in which the non-secretor phenotype is absent. METHODS: A 1:1 matched case-control study was conducted in northern Taiwan from February, 2013 to December, 2014 when an epidemic of norovirus infection occurred. Cases were children < 18 years old who were hospitalized because of diarrhea and were found to have laboratory-confirmed norovirus infections...
December 1, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27895641/pneumococcal-polysaccharide-vaccination-elicits-igg-anti-a-b-blood-group-antibodies-in-healthy-individuals-and-patients-with-type-i-diabetes-mellitus
#17
Wendelin Wolfram, Kai M T Sauerwein, Christoph J Binder, Nicole Eibl-Musil, Hermann M Wolf, Michael B Fischer
HYPOTHESIS: Blood group antibodies are natural antibodies that develop early in life in response to cross-reactive environmental antigens in the absence of antigen encounter. Even later in life structural similarities in saccharide composition between environmental antigens such as bacterial polysaccharides and blood group A/B antigens could lead to changes in serum levels, IgM/IgG isotype, and affinity maturation of blood group anti-A/B antibodies. We addressed the question whether immunization with pneumococcal polysaccharide (PnP) vaccine Pneumo 23 Vaccine "Pasteur Merieux" (Pn23) could have such an effect in patients with type I diabetes mellitus (DM I), an autoimmune disease where an aberrant immune response to microbial antigens likely plays a role...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27893352/prevalence-of-antibodies-to-a-new-histo-blood-system-the-fors-system
#18
Carlos Jesus, Camilla Hesse, Clara Rocha, Nádia Osório, Ana Valado, Armando Caseiro, António Gabriel, Lola Svensson, Ali-Reza Moslemi, Wafa Abu Siba, Mahmoud A Srour, Cristina Pereira, Jorge Tomaz, Paulo Teixeira, Fernando Mendes
BACKGROUND: In 1987, three unrelated English families were reported with a putative blood subgroup called Apae. Swedish researchers later found evidence leading to abolishment of the Apae subgroup and establishment instead of the FORS blood group system (System 31 - ISBT, 2012). It is important to know the prevalence of antibodies in order to make the best decisions in transfusion medicine. Cells expressing the Forssman saccharide, such as sheep erythrocytes, are needed to detect the anti-Forssman antibody...
October 24, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27859559/fut2-non-secretor-status-is-associated-with-type-1-diabetes-susceptibility-in-japanese-children
#19
K Ihara, C Fukano, T Ayabe, M Fukami, T Ogata, T Kawamura, T Urakami, N Kikuchi, I Yokota, K Takemoto, T Mukai, A Nishii, T Kikuchi, T Mori, N Shimura, G Sasaki, R Kizu, N Takubo, S Soneda, T Fujisawa, R Takaya, Z Kizaki, S Kanzaki, K Hanaki, N Matsuura, Y Kasahara, K Kosaka, T Takahashi, K Minamitani, S Matsuo, H Mochizuki, K Kobayashi, A Koike, R Horikawa, S Teno, K Tsubouchi, T Mochizuki, Y Igarashi, S Amemiya, S Sugihara
AIM: To examine the contribution of the FUT2 gene and ABO blood type to the development of Type 1 diabetes in Japanese children. METHODS: We analysed FUT2 variants and ABO genotypes in a total of 531 Japanese children diagnosed with Type 1 diabetes and 448 control subjects. The possible association of FUT2 variants and ABO genotypes with the onset of Type 1 diabetes was statistically examined. RESULTS: The se2 genotype (c.385A>T) of the FUT2 gene was found to confer susceptibility to Type 1A diabetes in a recessive effects model [odds ratio for se2/se2, 1...
November 18, 2016: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27843110/-recipients-adverse-reactions-in-the-ibn-sina-hospital-of-rabat-state-1999-2013
#20
S Ouadghiri, C Brick, N Benseffaj, O Atouf, M Essakalli
PURPOSE OF STUDY: The declaration of the recipients adverse reactions (RAR) is one of the field haemovigilance activities. It provides an evaluation of transfusion side effects and thus prevents their appearance. The aim of this study is to analyze, over 14 years, the RAR supports reported in Rabat Ibn Sina hospital. PATIENTS AND METHODS: All of the RAR supports sending to the blood transfusion service were analyzed. The data collected from these supports are: clinical characteristics of the patient, type of incident observed and type of labile blood products (LBP) transfused...
November 11, 2016: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
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