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https://www.readbyqxmd.com/read/29898094/standardization-of-the-infusion-sequence-of-antineoplastic-drugs-used-in-the-treatment-of-breast-and-colorectal-cancers
#1
Amanda Alves da Silva, Juliane Carlotto, Inajara Rotta
The definition of antineoplastic administration sequences can help planning of therapeutic regimens in a more rational way, and thus optimize chemotherapy effects on patients, increasing efficacy and reducing toxic effects. In this way, this study aimed to evaluate the infusion order of antineoplastic agents of the main therapeutic protocols used in the treatment of colorectal and breast cancer which are used in a tertiary hospital, identifying possible interactions dependent on the infusion sequence. For the definition of protocols adopted in the hospital, medical prescriptions were used in the period of January to March 2016 and a literature review was conducted to search for studies assessing the sequence of administering the selected regimens...
June 7, 2018: Einstein
https://www.readbyqxmd.com/read/29781322/the-impact-of-chronic-kidney-disease-on-medication-choice-and-pharmacologic-management-in-patients-with-heart-failure
#2
Syed Raza Shah, David E Winchester
In the past few years, medical community, including doctors, have become increasingly aware of the fact that chronic kidney disease (CK) and heart failure (HF) have common risk factors which impacts one another in terms of choice of therapy. Areas covered: Management of these two diseases has been a challenge for physicians. The treatment goals for HF patients in CK are very important. They serve as the end-point in using a specific treatment for management and treatment of CK patients hence, decreasing mortality rates...
May 21, 2018: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/29779575/thirty-day-readmissions-in-surgical-and-transcatheter-aortic-valve-replacement-a-systematic-review-and-meta-analysis
#3
Stein Ove Danielsen, Philip Moons, Irene Sandven, Marit Leegaard, Svein Solheim, Theis Tønnessen, Irene Lie
BACKGROUND: The 30-day all-cause readmission rate after surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) vary substantially. We conducted a systematic review and meta-analysis to examine the overall incidence, causes, and risk factors of 30-day all-cause readmission rate after SAVR and TAVR. METHODS: Eight medical research databases were searched; Cochrane, Medline, Embase, UpToDate, PROSPERO, National Guideline Clearinghouse, SweMed and Oria...
May 17, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29706275/medical-apps-used-during-advanced-pharmacy-practice-experiences
#4
Krista L Donohoe, Abigale T Matulewicz, Fawaz M Alotaibi, Kelechi C Ogbonna
BACKGROUND AND PURPOSE: The purpose of this study was to determine what type of medical applications (apps) are being used by fourth-year students during advanced pharmacy practice experiences (APPEs). EDUCATIONAL ACTIVITY AND SETTING: Recent doctor of pharmacy school graduates were surveyed pertaining to their use of medical apps on APPEs, frequency of use for select apps, willingness to buy apps and at what cost, and their perceived importance on using medical apps in their pharmacy practice...
February 2018: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29696942/challenges-of-fertility-preservation-in-leukemia-patients
#5
Moran Shapira, Hila Raanani, Sanaz Derech Chaim, Dror Meirow
An ongoing increase in survival rates among young leukemia patients is accompanied by a growing attention to possible long-term complications such as chemotherapy induced ovarian insufficiency and infertility. Therefore, an important element of the management of these patients is fertility preservation, which is challenged by considerations specific for leukemia. Such considerations include prepuberty, poor medical condition on presentation and the need for urgent chemotherapy, all of which may preclude the use of conventional assisted reproductive technologies...
April 24, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29651322/management-of-frailty-at-individual-level-clinical-management-systematic-literature-review
#6
REVIEW
Gregor Veninšek, Branko Gabrovec
Introduction: To deliver quality management of a frail individual, a clinician should understand the concept of frailty, be aware of its epidemiology and be able to screen for frailty and assess it when it is present, and, finally, to recommend successful interventions. Methodology: A systematic literature search was conducted in the following databases: PubMed, Cochrane, Embase, Cinahl and UpToDate. The criterion in selecting the literature was that articles were published in the period from 2002 to 2017...
June 2018: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/29609048/use-of-immunology-and-immunodeficiency-topics-in-uptodate
#7
E Richard Stiehm, Elizabeth C TePas, Anna M Feldweg
No abstract text is available yet for this article.
March 30, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29606552/sexual-activity-recommendations-in-high-risk-pregnancies-what-is-the-evidence
#8
REVIEW
Sally E MacPhedran
BACKGROUND: While sexual activity in normal, healthy pregnant women is safe, concern regarding elements of the sexual act have led to restrictions in pregnancies experiencing complications that are frequently insufficiently addressed in clinical practice. AIM: To comprehensively review the literature for evidence that supports or refutes specific sexual activity restrictions in high-risk pregnancy conditions. METHODS: A search of PubMed, MEDLINE, Ovid, UpToDate, Google Scholar, and Google for relevant publications related to any aspect of sexual activity affecting high-risk pregnancies complicated by history of pre-term delivery, shortened cervix, presence of cerclage, pre-mature rupture of membranes, placenta abruption, placenta previa, multiple gestation, or history of classical cesarean section was performed...
March 29, 2018: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29501059/review-of-oritavancin-for-the-treatment-of-acute-bacterial-skin-and-skin-structure-infections
#9
Ana Alejandra García Robles, Eduardo López Briz, María Dolores Fraga Fuentes, Rocío Asensi Diez, Jesús Francisco Sierra Sánchez
OBJECTIVE: To assess critically oritavancin, a second-generation  lipoglycopeptide, for the treatment of Acute Bacterial Skin and Skin Structure Infections caused by susceptible Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus. METHOD: An evaluation report of oritavancin in Acute Bacterial Skin and Skin  Structure Infections was carried out according to the methodology of the Group  for drug evaluation, standardization and research in drug selection of the  Spanish Society of Hospital Pharmacy (SEFH)1, with the MADRE 4...
March 1, 2018: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/29493481/empiric-antibiotic-prescribing-decisions-among-medical-residents-the-role-of-the-antibiogram
#10
Gregory B Tallman, Rowena A Vilches-Tran, Miriam R Elman, David T Bearden, Jerusha E Taylor, Paul N Gorman, Jessina C McGregor
OBJECTIVETo assess general medical residents' familiarity with antibiograms using a self-administered surveyDESIGNCross-sectional, single-center surveyPARTICIPANTSResidents in internal medicine, family medicine, and pediatrics at an academic medical centerMETHODSParticipants were administered an anonymous survey at our institution during regularly scheduled educational conferences between January and May 2012. Questions collected data regarding demographics, professional training; further open-ended questions assessed knowledge and use of antibiograms regarding possible pathogens, antibiotic regimens, and prescribing resources for 2 clinical vignettes; a series of directed, closed-ended questions followed...
May 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29388523/antidepressants-in-paediatric-depression-do-not-look-back-in-anger-but-around-in-awareness
#11
David A Brent, Robert D Gibbons, Paul Wilkinson, Bernadka Dubicka
In this paper, we summarise and critique a network meta-analysis (NMA) of antidepressant efficacy and tolerability for paediatric depression and an accompanying editorial. Although we agree that many of the extant studies are flawed, this meta-analysis showed clear efficacy of fluoxetine in the NMA, and for sertraline and escitalopram in pairwise analyses. Consequently, these papers underestimate the benefits of antidepressants for paediatric depression, and provide support for current practice guideline, which recommends the use of an antidepressant if the patient does not respond to psychotherapy...
February 2018: BJPsych Bulletin
https://www.readbyqxmd.com/read/29380236/drug-related-problems-identified-by-clinical-pharmacist-at-the-internal-medicine-ward-in-turkey
#12
Nibal Abunahlah, Anfal Elawaisi, Fatih Mehmet Velibeyoglu, Mesut Sancar
Background Drug-related problems (DRPs) interfere with patient optimal therapeutic outcomes and may be associated with higher morbidity, mortality and healthcare expenditures. Objective This study aimed to identify DRPs and their causes in a Turkish hospital. Setting Bakirkoy Dr. Sadi Konuk Teaching and Research Hospital, Internal Medicine Ward, Istanbul, Turkey. Method Cross-sectional study included a total of 100 patients. Patient demographics, medications, and history were evaluated. Data regarding recent medications were analyzed by two clinical pharmacists and an Internal Medicine physician...
April 2018: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/29195700/effectiveness-of-a-clinical-knowledge-support-system-for-reducing-diagnostic-errors-in-outpatient-care-in-japan-a-retrospective-study
#13
Taro Shimizu, Takaaki Nemoto, Yasuharu Tokuda
Clinical evidence has indicated the effectiveness of computer-based systems for preventing and reducing diagnostic errors. Our study aimed to evaluate the effectiveness of UpToDate, a computer-based clinical knowledge management system, for reducing diagnostic errors. We retrospectively identified 100 patients who visited an outpatient department in a community-based hospital from July 2014 to June 2015. Fifty patients (exposure group) were seen by UpToDate-equipped physicians and another 50 (control group) were seen by UpToDate-unequipped physicians...
January 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29150475/uptodate-adherence-to-grade-criteria-for-strong-recommendations-an-analytical-survey
#14
Thomas Agoritsas, Arnaud Merglen, Anja Fog Heen, Annette Kristiansen, Ignacio Neumann, Juan P Brito, Romina Brignardello-Petersen, Paul E Alexander, David M Rind, Per O Vandvik, Gordon H Guyatt
INTRODUCTION: UpToDate is widely used by clinicians worldwide and includes more than 9400 recommendations that apply the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. GRADE guidance warns against strong recommendations when certainty of the evidence is low or very low (discordant recommendations) but has identified five paradigmatic situations in which discordant recommendations may be justified. OBJECTIVES: Our objective was to document the strength of recommendations in UpToDate and assess the frequency and appropriateness of discordant recommendations...
November 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/29108136/application-and-optimisation-of-the-comparison-on-extreme-laboratory-tests-cert-algorithm-for-detection-of-adverse-drug-reactions-transferability-across-national-boundaries
#15
Mun Yee Tham, Qing Ye, Pei San Ang, Liza Y Fan, Dukyong Yoon, Rae Woong Park, Zheng Jye Ling, James W Yip, Bee Choo Tai, Stephen Jw Evans, Cynthia Sung
PURPOSE: The Singapore regulatory agency for health products (Health Sciences Authority), in performing active surveillance of medicines and their potential harms, is open to new methods to achieve this goal. Laboratory tests are a potential source of data for this purpose. We have examined the performance of the Comparison on Extreme Laboratory Tests (CERT) algorithm, developed by Ajou University, Korea, as a potential tool for adverse drug reaction detection based on the electronic medical records of the Singapore health care system...
January 2018: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29089291/comparison-of-the-impact-of-wikipedia-uptodate-and-a-digital-textbook-on-short-term-knowledge-acquisition-among-medical-students-randomized-controlled-trial-of-three-web-based-resources
#16
Michael A Scaffidi, Rishad Khan, Christopher Wang, Daniela Keren, Cindy Tsui, Ankit Garg, Simarjeet Brar, Kamesha Valoo, Michael Bonert, Jacob F de Wolff, James Heilman, Samir C Grover
BACKGROUND: Web-based resources are commonly used by medical students to supplement curricular material. Three commonly used resources are UpToDate (Wolters Kluwer Inc), digital textbooks, and Wikipedia; there are concerns, however, regarding Wikipedia's reliability and accuracy. OBJECTIVE: The aim of this study was to evaluate the impact of Wikipedia use on medical students' short-term knowledge acquisition compared with UpToDate and a digital textbook. METHODS: This was a prospective, nonblinded, three-arm randomized trial...
October 31, 2017: JMIR Medical Education
https://www.readbyqxmd.com/read/29034722/the-efficacy-of-apaziquone-in-the-treatment-of-bladder-cancer
#17
REVIEW
Francisco Caramés Masana, Theo M de Reijke
Bladder cancer is nowadays a common tumor. Non-muscle invasive bladder cancer (NMIBC) has still chances of recurrence and progression in spite of surgery and adjuvant treatments. New therapies are being developed to reduce these percentages with less adverse effects - Apaziquone (EO9) is an example. Areas covered: A literature search has been performed using Pubmed, UpToDate and Google verified information (mainly from Food and Drug Administration and Spectrum Pharmaceutics websites). We have included data from the most representative clinical trials and reviews published...
November 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28852652/postpartum-depression-risk-factors-a-narrative-review
#18
REVIEW
Maryam Ghaedrahmati, Ashraf Kazemi, Gholamreza Kheirabadi, Amrollah Ebrahimi, Masood Bahrami
Postpartum depression is a debilitating mental disorder with a high prevalence. The aim of this study was review of the related studies. In this narrative review, we report studies that investigated risk factors of postpartum depression by searching the database, Scopus, PubMed, ScienceDirect, Uptodate, Proquest in the period 2000-2015 published articles about the factors associated with postpartum depression were assessed in Farsi and English. The search strategy included a combination of keywords include postpartum depression and risk factors or obstetrical history, social factors, or biological factors...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/28810192/vaginal-and-laparoscopic-hysterectomy-as-an-outpatient-procedure-a-systematic-review
#19
Suzanne J Dedden, Peggy M A J Geomini, Judith A F Huirne, Marlies Y Bongers
OBJECTIVES: Laparoscopic and vaginal hysterectomies are common gynaecological procedures. Same-day discharge is usual care in various gynaecological procedures like laparoscopic sterilisation and laparoscopic oophorectomies. In major procedures like vaginal or laparoscopic hysterectomy patients are usually admitted overnight. We systematically reviewed the literature to identify complications, risk factors for (re)admittance, financial consequences and patient satisfaction of same-day discharge after a vaginal or laparoscopic hysterectomy...
September 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28806791/effect-of-access-to-an-electronic-medical-resource-on-performance-characteristics-of-a-certification-examination-a-randomized-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
Rebecca S Lipner, Bradley G Brossman, Kelli M Samonte, Steven J Durning
Background: Electronic resources are increasingly used in medical practice. Their use during high-stakes certification examinations has been advocated by many experts, but whether doing so would affect the capacity to differentiate between high and low abilities is unknown. Objective: To determine the effect of electronic resources on examination performance characteristics. Design: Randomized controlled trial. Setting: Medical certification program...
September 5, 2017: Annals of Internal Medicine
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