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https://www.readbyqxmd.com/read/27930460/ocular-manifestations-and-treatment-outcomes-in-chinese-patients-with-poems-syndrome
#1
Xiao Zhang, Qian-Qian Cai, Xu-Fei Huang, Xin-Xin Cao, Hao Cai, Dao-Bin Zhou, Rong-Ping Dai, Jian Li
PURPOSE: To evaluate the relationship of serum vascular endothelial growth factor (VEGF) levels and ocular manifestations in Chinese patients with POEMS syndrome. METHODS: This is a prospective study. Forty-one treatment-naive patients were enrolled from April 2014 to November 2014. Among the 41 patients, 40 had complete ocular examination, spectral domain optical coherence tomography scan, and serum VEGF measurement before treatment and every 3-month interval after lenalidomide and dexamethasone treatment...
December 7, 2016: Retina
https://www.readbyqxmd.com/read/27866728/what-is-new-in-2015-in-dysimmune-neuropathies
#2
REVIEW
T Kuntzer
This review discusses and summarizes the concept of nodopathies, the diagnostic features, investigations, pathophysiology, and treatment options of chronic inflammatory demyelinating polyradiculoneuropathy, and gives updates on other inflammatory and dysimmune neuropathies such as Guillain-Barré syndrome, sensory neuronopathies, small-fiber-predominant ganglionitis, POEMS syndrome, neuropathies associated with IgM monoclonal gammopathy and multifocal motor neuropathy. This field of research has contributed to the antigenic characterization of the peripheral motor and sensory functional systems, as well as helping to define immune neuropathic syndromes with widely different clinical presentation, prognosis and response to therapy...
December 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27834942/measurement-of-%C3%AE-isomerized-c-terminal-telopeptide-of-type-i-collagen-in-patients-with-poems-syndrome-diagnostic-prognostic-and-follow-up-utilities
#3
X Huang, C Zhang, C Wang, Q Cai, X Cao, H Cai, L Zhang, J Feng, D Zhou, J Li
No abstract text is available yet for this article.
November 11, 2016: Blood Cancer Journal
https://www.readbyqxmd.com/read/27822103/the-danish-national-multiple-myeloma-registry
#4
REVIEW
Peter Gimsing, Morten O Holmström, Tobias Wirenfelt Klausen, Niels Frost Andersen, Henrik Gregersen, Robert Schou Pedersen, Torben Plesner, Per Trøllund Pedersen, Mikael Frederiksen, Ulf Frølund, Carsten Helleberg, Annette Vangsted, Peter de Nully Brown, Niels Abildgaard
AIM: The Danish National Multiple Myeloma Registry (DMMR) is a population-based clinical quality database established in January 2005. The primary aim of the database is to ensure that diagnosis and treatment of plasma cell dyscrasia are of uniform quality throughout the country. Another aim is to support research. Patients are registered with their unique Danish personal identification number, and the combined use of DMMR, other Danish National registries, and the Danish National Cancer Biobank offers a unique platform for population-based translational research...
2016: Clinical Epidemiology
https://www.readbyqxmd.com/read/27807187/clinical-spectrum-of-castleman-disease-associated-neuropathy
#5
Elie Naddaf, Angela Dispenzieri, Jay Mandrekar, Michelle L Mauermann
OBJECTIVE: To define the peripheral neuropathy phenotypes associated with Castleman disease. METHODS: We conducted a retrospective chart review for patients with biopsy-proven Castleman disease evaluated between January 2003 and December 2014. Patients with associated peripheral neuropathy were identified and divided into 2 groups: those with Castleman disease without POEMS syndrome (CD-PN) and those with Castleman disease with POEMS syndrome (CD-POEMS). We used a cohort of patients with POEMS as controls...
December 6, 2016: Neurology
https://www.readbyqxmd.com/read/27799073/nerve-pathologic-features-differentiate-poems-syndrome-from-cidp
#6
Ezequiel A Piccione, Janean Engelstad, Peter J Dyck, Michelle L Mauermann, Angela Dispenzieri, P James B Dyck
The objective of this study is to determine if the nerve pathology in patients with POEMS syndrome is different from CIDP. We hypothesized that nerve biopsies from patients with POEMS syndrome would have more small vessels and axonal degeneration but less inflammation than CIDP.We performed a retrospective analysis of nerve biopsies performed on "classic" CIDP and POEMS cases. Nerve biopsies were blinded and reviewed by two of the authors (EAP, PJBD). Teased fibers, paraffin-embedded sections, semithin sections and immunostains were analyzed...
October 31, 2016: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/27790622/an-occult-malignancy-behind-a-demyelinating-disease-poems-syndrome
#7
Saberio Lo Presti, Prashanth Kanagarajah, Daniela Pirela, Diana Morlote, Mike Cusnir
We report a case of a 38-year-old man presenting with bilateral lower extremity weakness and paresthesias that progressed during a 4-month period to severe polyneuropathy forcing the patient to be bed bound. Throughout his multiple hospitalizations, he was treated erroneously for chronic inflammatory demyelinating polyneuropathy, without significant improvement in his symptoms. In addition, he developed hepatosplenomegaly (organomegaly); endocrinopathies such as diabetes mellitus, central hypogonadism, and hypothyroidism; monoclonal spike evidenced in the serum electrophoresis; and hyperpigmentation of skin, altogether consistent with POEMS syndrome...
October 2016: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/27738309/young-patient-with-arterial-thrombosis-and-skin-changes-as-the-onset-manifestations-poems-syndrome
#8
Ting-Ting Han, Shuang Zheng, Zeng-Ai Chen, Wei Liu, Yao-Min Hu
POEMS syndrome is a rare multi-systemic disease characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes. Arterial thrombosis is a distinctively unusual feature in patients with POEMS syndrome. We report a 33-year-old man with intermittent amaurosis of left eye and skin changes as the onset manifestations, who was finally confirmed as having POEMS syndrome. Most notably, this was a young man without high risk factors of arterial thrombosis and no monoclonal protein was detected until the repeated measurement later...
October 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27726462/temporal-and-spatial-correlation-between-choroidal-thickness-and-visual-function-in-a-case-of-poems-syndrome
#9
Julio González-Martin-Moro, Inés Contreras, Belén Pilo-de-la-Fuente, Fernando Gómez-Sanz
PURPOSE: To report the correlation between visual function and subfoveal choroidal thickness (SChT) in a case of POEMS syndrome. CASE REPORT: A 53 year old man diagnosed with POEMS syndrome was referred due to blurred vision. Best corrected visual acuity (BCVA) was 0.5 in his right eye (RE) and 0.7 in his left eye (LE), with a mild perimetric defect in the RE. SChT was 356 and 263 µm in his RE and LE. After an autologous peripheral blood stem-cell transplantation, both visual and systemic symptoms improved...
October 11, 2016: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/27707692/changes-in-subfoveal-choroidal-thickness-and-reduction-of-serum-levels-of-vascular-endothelial-growth-factor-in-patients-with-poems-syndrome
#10
Hirotaka Yokouchi, Takayuki Baba, Sonoko Misawa, Masayasu Kitahashi, Toshiyuki Oshitari, Satoshi Kuwabara, Shuichi Yamamoto
AIMS: To determine the changes in the subfoveal choroidal thickness (CT), the foveal thickness (FT) and the serum level of vascular endothelial growth factor (VEGF) after thalidomide treatment in patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes (POEMS) syndrome. METHODS: We studied 13 left eyes of 13 treatment-naïve patients with POEMS syndrome. The subfoveal CT and FT were determined by enhanced depth imaging optical coherence tomography, and the serum level of VEGF was determined by ELISA at the baseline and at 6 months after thalidomide treatment...
October 4, 2016: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/27697660/remarkable-expression-of-vascular-endothelial-growth-factor-in-bone-marrow-plasma-cells-of-patients-with-poems-syndrome
#11
Chen Wang, Xu-Fei Huang, Qian-Qian Cai, Xin-Xin Cao, Hao Cai, Daobin Zhou, Jian Li
Vascular endothelial growth factor (VEGF) is pathognomonically elevated in patients with POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) syndrome. However, its source of overproduction is unclear. As clinical improvement is almost always associated with VEGF reduction after anti-plasma cell therapy, its increase at diagnosis has been attributed to the underlying monoclonal gammopathy, although direct evidence is still lacking. In the current study, we systemically measured VEGF levels in POEMS patients, before and after treatment...
September 26, 2016: Leukemia Research
https://www.readbyqxmd.com/read/27649853/a-rare-case-of-worsening-of-parkes-weber-syndrome-with-development-of-poems-syndrome
#12
Olivier Espitia, Jerome Connault, Mohamed A Hamidou
No abstract text is available yet for this article.
November 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27634201/high-dose-therapy-and-autologous-stem-cell-transplantation-in-patients-with-poems-syndrome-a-retrospective-study-of-the-plasma-cell-disorder-sub-committee-of-the-chronic-malignancy-working-party-of-the-european-society-for-blood-marrow-transplantation
#13
Gordon Cook, Simona Iacobelli, Anja van Biezen, Dimitris Ziagkos, Veronique LeBlond, Julie Abraham, Grant McQuaker, Stefan Schoenland, Alessandro Rambaldi, Kazimierz Halaburda, Maria Rovira, Simona Sica, Jenny Byrne, Ramon Garcia Sanz, Arnon Nagler, Niels W C J van de Donk, Marjatta Sinisalo, Mark Cook, Nicolaus Kröger, Theo De Witte, Curly Morris, Laurent Garderet
POEMS syndrome is a rare para-neoplastic syndrome secondary to a plasma cell dyscrasia. Effective treatment can control the disease-related symptom complex. We describe the clinical outcome of autologous stem cell transplantation for patients with POEMS syndrome, determining the impact of patient and disease-specific factors on prognosis. 127 patients underwent an autologous stem cell transplantation between 1997-2010 with a median age of 50 years (range 26-69). The median time from diagnosis to ASCT was 7...
September 15, 2016: Haematologica
https://www.readbyqxmd.com/read/27630082/poems-syndrome-a-rare-case-report
#14
Benedetta Miglino, Michele Viana, Rossana Tiberio, Paolo Boggio, Guido Valente, Gionata Strigaro, Enrico Colombo
The authors report a case of sensorimotor polyneuropathy, diffuse hemangiomas and monoclonal gammopathy. Besides weight loss, there were diabetes mellitus and severe hypothyroidism. These alterations were consistent with POEMS (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal gammopathy and Skin changes) syndrome, which is a rare systemic disease with monoclonal proliferation of plasmacytes and slow progression. Because of its rarity, the incidence of this disease is still unknown.
September 15, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27547585/bone-lesions-in-chinese-poems-syndrome-patients-imaging-characteristics-and-clinical-implications
#15
Fengdan Wang, Xufei Huang, Yan Zhang, Jian Li, Daobin Zhou, Zhengyu Jin
Objective. Bone lesion is crucial for diagnosing and management of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin change (POEMS) syndrome, a rare plasma cell disorder. This study is to compare the effectiveness of X-ray skeletal survey (SS) and computed tomography (CT) for detecting bone lesions in Chinese POEMS syndrome patients, and to investigate the relationship between bone lesion features and serum markers. Methods. SS and chest/abdomen/pelvic CT images of 38 Chinese patients (26 males, 12 females, aged 21-70 years) with POEMS syndrome recruited at our medical center between January 2013 and January 2015 were retrospectively analyzed...
2016: PeerJ
https://www.readbyqxmd.com/read/27531391/skin-manifestations-of-poems-and-aesop-syndrome-in-the-same-patient-revealing-plasma-cell-dyscrasia
#16
Franco Rongioletti, Maria C Failla, Laura Atzori, Caterina Ferreli
POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin signs) and AESOP (adenopathy and extensive skin patch overlying a plasmacytoma) syndromes are rare paraneoplastic conditions due to an underlying plasma cell dyscrasia. We report a 70-year-old patient with the rare coexistence of POEMS and AESOP syndromes and in whom skin signs, that differ both clinically and histologically, were the clues to the diagnosis of a plasma cell disorder. Vascular endothelial growth factor-A overexpression seems to be the common pathogenetic link of the different clinicopathological presentations of the skin lesions...
December 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27496680/safety-and-efficacy-of-thalidomide-in-patients-with-poems-syndrome-a-multicentre-randomised-double-blind-placebo-controlled-trial
#17
Sonoko Misawa, Yasunori Sato, Kanako Katayama, Kengo Nagashima, Reiko Aoyagi, Yukari Sekiguchi, Gen Sobue, Haruki Koike, Ichiro Yabe, Hidenao Sasaki, Osamu Watanabe, Hiroshi Takashima, Masatoyo Nishizawa, Izumi Kawachi, Susumu Kusunoki, Yoshiyuki Mitsui, Seiji Kikuchi, Ichiro Nakashima, Shu-Ichi Ikeda, Nobuo Kohara, Takashi Kanda, Jun-Ichi Kira, Hideki Hanaoka, Satoshi Kuwabara
BACKGROUND: Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare cause of demyelinating neuropathy, with multi-organ involvement characterised by plasma cell dyscrasia and VEGF overproduction. No treatments have been established for patients with POEMS syndrome who are not eligible for stem-cell transplantation. Thalidomide suppresses VEGF and plasma cell proliferation. We aimed to assess the safety and efficacy of thalidomide for the treatment of POEMS syndrome...
October 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27496679/thalidomide-and-poems-syndrome-a-cautious-step-forward
#18
Arnaud Jaccard, Laurent Magy
No abstract text is available yet for this article.
October 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27453713/a-rare-case-of-polyneuropathy-and-monoclonalgammopathy-with-recurrent-acute-kidney-injury
#19
Eun Jung Kim, Dong Ho Shin, Hee Jung Jeon, So Yon Rhee, Eun Sook Nam, Ji Young Park, Jieun Oh
POEMS syndrome is a rare paraneoplastic syndrome and there are few reports of polyneuropathy and monoclonal gammopathy associated with kidney dysfunction. Here, we report a case of POEMS syndrome with recurrent acute kidney injury (AKI). A 52-year-old man presented with bilateral aggravating paresthesia and latermotor weakness of the lower extremities accompanied by repeated elevation of serum creatinine. The patient was finally diagnosed with POEMS syndrome on the basis of fulfilling the two mandatory major criteria (polyneuropathy and monoclonal gammopathy), one other major criterion (sclerotic bone lesion), and several minor criteria...
June 2016: Electrolyte & Blood Pressure: E & BP
https://www.readbyqxmd.com/read/27401385/-chronic-kidney-disease-associated-with-poems-syndrome-report-of-one-case
#20
Jorge Vega
POEMS syndrome is characterized by Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal protein and Skin changes. We report a woman with the syndrome, who had peripheral polyneuropathy, osteosclerotic myeloma, monoclonal IgA elevation, hypothyroidism, hypogonadotrophic hypogonadism, hyperprolactinemia, adrenal insufficiency, hepatosplenomegaly, lymphadenopathy, thyroid and parotid enlargement, Castleman’s disease, papilledema, stiff and hyperpigmented skin, white nails, clubbing, ascites and chronic diarrhea...
April 2016: Revista Médica de Chile
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