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Autism antidepressants

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https://www.readbyqxmd.com/read/28335658/dopamine-antagonists-for-treatment-resistance-in-autism-spectrum-disorders-review-and-focus-on-bdnf-stimulators-loxapine-and-amitriptyline
#1
Jessica A Hellings, L Eugene Arnold, Joan Han
Drug development is urgently needed for individuals with autism spectrum disorders (ASD) and psychiatric comorbidity, which often presents as aggression and self-injury. At the same time, most psychiatric medications are drugs that have been repurposed following clinical observations of efficacy for a new treatment purpose. Areas Covered: This review aims to provide an overview of dopamine antagonists, including classical and atypical, as well as unconventional antipsychotics in ASD, since they are a mainstay of treatment for such problems...
March 24, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28315722/risk-mitigation-for-children-exposed-to-drugs-during-gestation-a-critical-role-for-animal-preclinical-behavioral-testing
#2
REVIEW
Irving Zucker
Many drugs with unknown safety profiles are administered to pregnant women, placing their offspring at risk. I assessed whether behavioral outcomes for children exposed during gestation to antidepressants, anxiolytics, anti-seizure, analgesic, anti-nausea and sedative medications can be predicted by more extensive animal studies than are part of the FDA approval process. Human plus rodent data were available for only 8 of 33 CNS-active drugs examined. Similar behavioral and cognitive deficits, including autism and ADHD emerged in human offspring and in animal models of these disorders after exposure to fluoxetine, valproic acid, carbamazepine, phenytoin, phenobarbital and acetaminophen...
March 16, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28287253/the-rodent-forced-swim-test-measures-stress-coping-strategy-not-depression-like-behavior
#3
Kathryn G Commons, Aram B Cholanians, Jessica A Babb, Daniel G Ehlinger
The Forced Swim Test (FST) measures coping strategy to an acute inescapable stress and thus provides unique insight into the neural limb of the stress response. Stress, particularly chronic stress, is a contributing factor to depression in humans and depression is associated with altered response to stress. In addition, drugs that are effective antidepressants in humans typically promote active coping strategy in the FST. As a consequence passive coping in the FST has become loosely equated with depression and is often referred to as 'depression-like' behavior...
March 13, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28244813/pharmacogenomics-of-autism-spectrum-disorder
#4
Jacob T Brown, Seenae Eum, Edwin H Cook, Jeffrey R Bishop
Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and interactions as well as restricted, repetitive behaviors and interests. Pharmacologic interventions are often needed to manage irritability, aggressive behaviors and hyperactivity. Pharmacogenomic studies have investigated genetic associations with treatment response and side effects in an attempt to better understand drug mechanisms in hopes of optimizing the balance of symptom improvement versus side effects...
March 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28213183/a-role-for-the-serotonin-reuptake-transporter-in-the-brain-and-intestinal-features-of-autism-spectrum-disorders-and-developmental-antidepressant-exposure
#5
REVIEW
Kara Gross Margolis
Many disease conditions considered CNS-predominant harbor significant intestinal comorbidities. Serotonin (5-HT) and the serotonin reuptake transporter (SERT) have increasingly been shown to play important roles in both brain and intestinal development and long-term function. 5-HT and SERT may thus modulate critical functions in the development and perpetuation of brain-gut axis disease. We discuss the potential roles of 5-HT and SERT in the brain and intestinal manifestations of autism spectrum disorders and developmental antidepressant exposure...
February 14, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28093058/off-label-prescribing-of-psychotropic-medication-2005-2013-an-examination-of-potential-influences
#6
Peggy L O'Brien, Nicholas Cummings, Tami L Mark
OBJECTIVE: This study examined rates of psychotropic prescriptions for various on- and off-label uses in 2005 and 2013 in the context of changes in labeled indications. METHODS: The National Disease and Therapeutic Index, a survey of nationally representative office-based physicians that identifies the diagnosis attached to each prescription, was used to capture the number of psychiatric medications prescribed for a particular diagnosis in 2005 (N=4,120) and 2013 (N=4,140)...
January 17, 2017: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27893495/integration-of-eeg-into-psychiatric-practice-a-step-toward-precision-medicine-for-autism-spectrum-disorder
#7
Ronald J Swatzyna, Jay D Tarnow, Robert P Turner, Alexandra J Roark, Erin K MacInerney, Gerald P Kozlowski
INTRODUCTION: Data from an EEG is not commonly used by psychiatrists to plan treatment and medication. However, EEG abnormalities such as isolated epileptiform discharges (IEDs) are found to be more prevalent in psychiatric patients, particularly those diagnosed with Autism Spectrum Disorder (ASD). Most medications prescribed for ASD lower seizure threshold and increase side-effects. Therefore, it may be prudent to order an EEG for ASD cases, especially those categorized as refractory...
November 22, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/27817163/psychotropic-medication-use-among-insured-children-with-autism-spectrum-disorder
#8
Jeanne M Madden, Matthew D Lakoma, Frances L Lynch, Donna Rusinak, Ashli A Owen-Smith, Karen J Coleman, Virginia P Quinn, Vincent M Yau, Yinge X Qian, Lisa A Croen
This study examined psychotropic medication use among 7901 children aged 1-17 with autism spectrum disorder (ASD) in five health systems, comparing to matched cohorts with no ASD. Nearly half (48.5 %) of children with ASD received psychotropics in the year observed; the most common classes were stimulants, alpha-agonists, or atomoxetine (30.2 %), antipsychotics (20.5 %), and antidepressants (17.8 %). Psychotropic treatment was far more prevalent among children with ASD, as compared to children with no ASD (7...
January 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/27738376/paroxetine-the-antidepressant-from-hell-probably-not-but-caution-required
#9
REVIEW
Robert M Nevels, Samuel T Gontkovsky, Bryman E Williams
Paroxetine, also known by the trade names Aropax, Paxil, Pexeva, Seroxat, Sereupin and Brisdelle, was first marketed in the U.S. in 1992. Effective for major depression and various anxiety disorders, it quickly gained a sizable share of the antidepressant prescription market. By the late 1990s, paroxetine frequently was being associated with serious drug interactions and medication side effects. Most significantly, in a major Canadian epidemiological study examining the relationship between antidepressants and diseases, paroxetine was associated with a 620 percent increase in the rate of breast cancer in women who had taken it over a four-year period...
March 1, 2016: Psychopharmacology Bulletin
https://www.readbyqxmd.com/read/27624381/use-of-psychotropic-drugs-in-patients-with-autism-spectrum-disorders-a-systematic-review
#10
REVIEW
K Jobski, J Höfer, F Hoffmann, C Bachmann
OBJECTIVE: The objective of this review was to examine prevalence and patterns of psychopharmacotherapy in individuals with autism spectrum disorder (ASD). METHOD: A systematic literature search in PubMed, CINAHL, and PsycINFO was performed, including articles published up to November 18, 2015. RESULTS: A total of 47 studies (data collection: 1976-2012), encompassing >300 000 individuals with ASD, were included. The prevalence of psychopharmacotherapy ranged from 2...
January 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/27591973/perinatal-exposure-to-the-selective-serotonin-reuptake-inhibitor-citalopram-alters-spatial-learning-and-memory-anxiety-depression-and-startle-in-sprague-dawley-rats
#11
Jenna L N Sprowles, Jillian R Hufgard, Arnold Gutierrez, Rebecca A Bailey, Sarah A Jablonski, Michael T Williams, Charles V Vorhees
Selective serotonin reuptake inhibitors (SSRIs) block the serotonin (5-HT) reuptake transporter (SERT) and increase synaptic 5-HT. 5-HT is also important in brain development; hence when SSRIs are taken during pregnancy there exists the potential for these drugs to affect CNS ontogeny. Prenatal SSRI exposure has been associated with an increased prevalence of autism spectrum disorder (ASD), and peripheral 5-HT is elevated in some ASD patients. Perinatal SSRI exposure in rodents has been associated with increased depression and anxiety-like behavior, decreased sociability, and impaired learning in the offspring, behaviors often seen in ASD...
November 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/27474253/autism-spectrum-disorder-and-prenatal-exposure-to-selective-serotonin-reuptake-inhibitors-a-systematic-review-and-meta-analysis
#12
Tohru Kobayashi, Tasuku Matsuyama, Masanobu Takeuchi, Shinya Ito
To obtain the risk estimates of autism spectrum disorder (ASD) in the offspring exposed to serotonin reuptake inhibitors (SSRI) in utero, we performed systematic review and meta-analysis of relevant studies. Five case-control and three cohort studies were eligible for the analysis. The SSRI group had significantly higher risk of ASD than the SSRI non-exposed group (pooled OR 1.45, 95% CI 1.15-1.82). In the subgroup analyses, however, the risk of ASD was similar between the SSRI group and other antidepressants group (pooled OR 1...
October 2016: Reproductive Toxicology
https://www.readbyqxmd.com/read/27371348/proteomic-investigation-of-the-prefrontal-cortex-in-the-rat-clomipramine-model-of-depression
#13
Barbara Gellén, Katalin Völgyi, Balázs András Györffy, Boróka Balogh, Zsuzsa Darula, Éva Hunyadi-Gulyás, Péter Baracskay, András Czurkó, István Hernádi, Gábor Juhász, Árpád Dobolyi, Katalin Adrienna Kékesi
Neonatal rodents chronically treated with the tricyclic antidepressant clomipramine show depression-like behavior, which persists throughout adulthood. Therefore, this animal model is suitable to investigate the pathomechanism of depression, which is still largely unknown at the molecular level beyond monoaminergic dysfunctions. Here, we describe protein level changes in the prefrontal cortex of neonatally clomipramine-treated adult rats correlating with behavioral abnormalities. Clomipramine was administered to rat pups twice daily between postnatal days 8-21, while controls received saline injections...
June 29, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27346512/autism-and-antidepressant-use-in-pregnancy
#14
Roy H Perlis
No abstract text is available yet for this article.
July 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27320508/-prevalence-of-the-use-of-psychoactive-medication-to-treat-young-persons-with-autism-spectrum-disorder-in-the-province-of-antwerp-belgium
#15
E Heyde, M Dhar, H Hellemans, E Schoentjes, D Van West
BACKGROUND: Very little information is available concerning the prevalence of the use of medication for treatment of individuals with autism spectrum disorder (ASD), particularly in European countries. Earlier studies have shown that a large number of patients with ASD use at least one psychoactive drug and that the numbers are increasing. Even in the nineties, studies suggested that the frequent use of psychoactive medication was widespread, although at the time there were only limited grounds for this assumption...
2016: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/27279529/an-introduction-to-the-psychopharmacology-of-children-and-adolescents-with-autism-spectrum-disorder
#16
Jason F Earle
TOPIC: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that requires a multidisciplinary approach to treatment. Psychopharmacology can play an important role within an array of services to help children and adolescents with ASD. PURPOSE: This article reviews the current evidence supporting the use of various psychiatric medications to treat common symptoms that often compromise functioning: severe irritability, interfering repetitive behaviors, ADHD, anxiety, depression, and sleep dysregulation...
May 2016: Journal of Child and Adolescent Psychiatric Nursing
https://www.readbyqxmd.com/read/27244697/prenatal-antidepressant-use-and-risk-of-autism-spectrum-disorders-in-children
#17
Pascal Bédard
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27244647/prenatal-antidepressant-use-and-risk-of-autism-spectrum-disorders-in-children
#18
Yusuf Cem Kaplan, Elif Keskin-Arslan, Selin Acar
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27244224/prenatal-antidepressant-use-and-risk-of-autism-spectrum-disorders-in-children-reply
#19
Anick Bérard, Takoua Boukhris
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27244054/prenatal-antidepressant-use-and-risk-of-autism-spectrum-disorders-in-the-children
#20
Eric Fombonne
No abstract text is available yet for this article.
July 1, 2016: JAMA Pediatrics
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