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https://www.readbyqxmd.com/read/29339807/overexpression-of-%C3%AE-1-6-fucosyltransferase-in-the-development-of-castration-resistant-prostate-cancer-cells
#1
Naseruddin Höti, Shuang Yang, Yingwei Hu, Punit Shah, Michael C Haffner, Hui Zhang
Glycosylation is recognized as one of the most common modifications on proteins. Recent studies have shown that aberrant expression of α (1,6) fucosyltransferase (FUT8), which catalyzes the transfer of fucose from GDP-fucose to core-GlcNAc of the N-linked glycoproteins, modulates cellular behavior that could lead to the development of aggressive prostate cancer. While the relationship between the abnormal expression of FUT8 and glycoprotein fucosylation in different prostate cancer cells has been demonstrated, there is no evidence that shows dysregulated fucosylation might be involved in prostate cancer progression from androgen-dependent to castration-resistant prostate cancer...
January 16, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29332536/the-rise-of-the-crime-victim-and-punitive-policies-changes-to-the-legal-regulation-of-intimate-partner-violence-in-finland
#2
Riikka Kotanen
This article examines intimate partnership violence as a question of criminal justice policy in Finland, and contributes to criminological discussions regarding oft-stated connections between the politicization of the victim, the treatment of offenders, and repressive criminal justice policies. In this discussion, legislation aiming to regulate and prevent violence against women has often been utilized as an example of such punitive policies. Although criminal policies in Nordic countries differ significantly from more punitive Anglophone policies, punitive tendencies, it has been argued, have increased in the former, too...
October 1, 2017: Violence Against Women
https://www.readbyqxmd.com/read/29326521/surgical-management-of-large-radicular-cyst-associated-with-mandibular-deciduous-molar-using-platelet-rich-fibrin-augmentation-a-rare-case-report
#3
Vijaya S Dhote, Nilima R Thosar, Sudhindra M Baliga, Priyanti Dharnadhikari, Poonam Bhatiya, Punit Fulzele
Radicular cysts arising from deciduous teeth are rare and usually cause a large bony defect. Autologous platelet-rich fibrin (PRF) is an easily available healing biomaterial in oral surgical defect with the new perspective of accelerated healing of a large bony defect. The present case is of unusually large radicular associated with neglected carious mandibular deciduous second molar in 10-year-old girl and its surgical management with PRF augmentation as a healing biomaterial in the bony defect. One-year follow-up showed uneventful healing and eruption of succedaneous tooth...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29304402/maternal-negative-emotional-expression-and-discipline-in-beijing-china-the-moderating-role-of-educational-attainment
#4
Feng Cheng, Yifang Wang, Xixian Wu, Zhuqing Su
The current study shows that parental punitive discipline places children at risk of developing internalizing and externalizing problems. Although some studies have analyzed the reasons for the use of discipline methods, little to no research has analyzed the moderating effects. In this study, we examine the relationship between maternal negative emotional expression and mothers' use of disciplinary methods (psychological aggression, corporal punishment and physical maltreatment) and the moderating effects of educational attainment in Chinese societies...
January 2, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29301982/search-of-multiple-hot-spots-on-the-surface-of-peptidyl-trna-hydrolase-structural-binding-and-antibacterial-studies
#5
Sanket Kaushik, Naseer Iqbal, Nagendra Singh, Juhi Sikarwar, Prashant K Singh, Pradeep Sharma, Punit Kaur, Sujata Sharma, Mohammad Owais, Tej P Singh
Peptidyl-tRNA hydrolase (Pth) catalyzes the breakdown of peptidyl-tRNA into peptide and tRNA components. Pth from Acinetobacter baumannii ( Ab Pth) was cloned, expressed, purified and crystallized in native unbound ( Ab Pth-N) state and in bound state with phosphate ion and cytosine arabinoside (cytarabine) ( Ab Pth-C). Structures of Ab Pth-N and Ab Pth-C were determined at 1.36Å and 1.10Å resolutions respectively.  Structure of Ab Pth-N showed that the active site is filled with water molecules. In the structure of Ab Pth-C, a phosphate ion is present in the active site while cytarabine is bound in a cleft which is located away from the catalytic site...
January 4, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29300361/dynamic-impact-of-online-word-of-mouth-and-advertising-on-supply-chain-performance
#6
Jian Feng, Bin Liu
Cooperative (co-op) advertising investments benefit brand goodwill and further improve supply chain performance. Meanwhile, online word-of-mouth (OWOM) can also play an important role in supply chain performance. On the basis of co-op advertising, this paper considers a single supply chain structure led by a manufacturer and examines a fundamental issue concerning the impact of OWOM on supply chain performance. Firstly, by the method of differential game, this paper analyzes the dynamic impact of OWOM and advertising on supply chain performance (i...
January 4, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29294952/the-failure-of-all-mothers-or-the-mother-of-all-failures-juror-perceptions-of-failure-to-protect-laws
#7
Marissa Stanziani, Jennifer Cox
Failure to protect laws have been an area of interest among legal scholars, child and domestic violence advocates, and the social work and psychology fields with varying focuses on the societal underpinnings of the laws and their application. Despite the pervasive legal literature on "mother blaming" and the revictimization of battered women that these laws engender, few studies have empirically examined if "mother blaming" occurs in these cases, or if battered women are treated more harshly. The aim of the present study was to investigate the impact of defendant sex and presence of domestic violence on mock juror decision making in a failure to protect case...
October 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294838/violent-discipline-behaviors-in-mothers-of-preschool-children-in-malatya-east-anatolia
#8
Mehtap Omaç Sönmez, Metin Fikret Genç, Leyla Karaoğlu
Violent parenting behavior, whether physical or psychological, give harms to child well-being. This study was conducted to describe and compare the prevalence of discipline methods used by mothers of 2- to 5-year-old children in Malatya, Turkey. This is a cross sectional study and 552 mothers were administered a face-to-face questionnaire describe the methods they use to discipline their children in the year previous the survey. It was observed that nine of 10 women used violence on their children physically and psychologically...
July 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294820/familicide-in-italy-an-exploratory-study-of-cases-involving-male-perpetrators-1992-2015
#9
Domenico Tosini
This article adds to the literature on familicide by providing specific insights from the Italian experience. It presents results of an exploratory investigation into male-perpetrated familicides in Italy between 1992 and 2015. Familicide is defined as the killing of the spouse or intimate partner, and at least one child, at the hand of the other spouse/partner. Incidents of familicide were collated from newspaper reports. We identified 90 cases, resulting in 207 deaths. On average, perpetrators were middle aged ( M = 46...
July 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294666/exploring-bullying-perpetration-and-victimization-among-adolescent-girls-in-the-child-welfare-system-bully-only-victim-only-bully-victim-and-noninvolved-roles
#10
Paul R Sterzing, Wendy F Auslander, G Allen Ratliff, Donald R Gerke, Tonya Edmond, Melissa Jonson-Reid
Childhood abuse is a common experience for youth in the child welfare system, increasing their risk of bullying perpetration and victimization. Little research exists that has examined the rates of bullying perpetration and victimization for child welfare-involved adolescent girls. The study addressed the following aims: (a) to generate frequency estimates of physical, nonphysical, and relational forms of bullying perpetration and victimization; (b) to identify the frequency of bully-only, victim-only, bully-victim, and noninvolved roles; and (c) to identify risk and protective factors that correlate with these bullying role types...
March 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29291142/implication-of-mutagenesis-and-precursor-supplementation-towards-the-enhancement-of-lipstatin-an-antiobesity-agent-biosynthesis-through-submerged-fermentation-using-streptomyces-toxytricini
#11
Punit Kumar, Kashyap Kumar Dubey
In the present study, lipstatin production was studied from different mutants of Streptomyces toxytricini which were developed using ultraviolet radiation (exposure time 30 s, 1, 2, 5 and 10 min), ethyl methane sulfonte, methyl methane sulfonate (MMS) and N-methyl-N'-intro-N-nitrosoguanidine (NTG) treatments (50, 100, 200, 500, 1000 µM, respectively). Highest yielding mutants were provided precursor supplementation of citric acid, thiamine and biotin (each 1 g/L) at idiophase for further enhancement in the production of lipstatin...
January 2018: 3 Biotech
https://www.readbyqxmd.com/read/29286615/epcam-based-flow-cytometric-detection-of-circulating-tumor-cells-in-gallbladder-carcinoma-cases
#12
Namrata Punit Awasthi, Swati Kumari, Azfar Neyaz, Sameer Gupta, Akash Agarwal, Ashish Singhal, Nuzhat Husain
Purpose: Liquid biopsy has entered the arena of cancer diagnostics in the past decade and detection of circulating tumor cells (CTC) is one diagnostic component. CTCs in gallbladder cancer (GBC) have hitherto not been comprehensively analysed. Methods and Results: The current study focused on the diagnostic role of CTCs in 27 cases of treatment-naive GBC and 6 normal controls as well as 6 cases of cholecystitis. An EasySep kit featuring negative immunomagnetic bead separation and flow cytometric detection of EpCAM positive and CD45 negative cells revealed CTCs in 25 of the 27 cases...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29279222/aggression-prevention-and-reduction-in-diverse-cultures-and-contexts
#13
REVIEW
Farida Anwar, Douglas P Fry, Ingrida Grigaitytė
It is not as difficult to prevent and reduce violence as commonly assumed. The examination of peaceful societies and nonviolent social movements provides insight on how core values and norms like humility, respect for others, love and caring, forgiveness, and patience are fundamental in promoting peace. Additionally, nonviolent attitudes actualized through nonviolent models and non-punitive childrearing practices can help socialize children to become nonviolent adults. At the group level, the commitment to nonviolence by individuals using methods of sit-ins, boycotts, strikes, work slow-downs, civil disobedience, marches, and demonstrations in struggles against violence and oppression can bring about positive social change...
February 2018: Current Opinion in Psychology
https://www.readbyqxmd.com/read/29273560/transnational-social-movement-theory-and-the-waning-war-on-drugs-case-studies-from-ungass-2016
#14
Ben Mostyn, Helen Gibbon
BACKGROUND: The United Nations Convention against Illicit Traffic in Narcotic Drugs 1988 ("1988 Convention") expresses a strong normative preference for criminalising drug possession. Historically, the United Nations offices responsible for overseeing the treaties have held that decriminalisation of drug possession is contrary to the treaties. Leading up to and during UNGASS 2016, however, rather than emphasise criminalisation, the high-ranking officials from the drug control offices emphasised the treaties' allowance of alternatives to punishment for drug possession offences...
December 19, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29258895/estimation-of-structure-and-stability-of-mure-ligase-from-salmonella-enterica-serovar-typhi
#15
Rohit Bansal, Md Anzarul Haque, Prakarsh Yadav, Deepali Gupta, Abdul S Ethayathulla, Md Imtaiyaz Hassan, Punit Kaur
MurE ligase catalyzes the assembly of peptide moiety, an essential component of bacterial cell wall. We have explored the conformational stability and unfolding equilibrium behaviour of the protein MurE ligase by determining the conformational free energy, entropy and enthalpy parameters under stress conditions. MurE from Salmonella enterica Serovar Typhi was cloned, expressed and purified. Conformational changes associated with increasing concentration of GdmCl- and urea-induced denaturation of MurE were monitored using Circular Dichroism (CD) and fluorescence spectroscopies...
December 16, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29237354/the-views-of-the-public-on-youth-offenders-and-the-new-zealand-criminal-justice-system
#16
Craig Barretto, Sarah Miers, Ian Lambie
Public perceptions of crime and punishment have taken on increasing importance as countries grapple with how to address youth violence. The current study aimed to compare the views of those who have had personal experience of victimisation from youth offenders and those who have not, on what could be improved in managing youth offending in New Zealand. A qualitative methodology was used with data from open-ended survey responses from a nationally representative sample. Public sentiments favoured addressing systemic issues and providing rehabilitation as main emphases followed by more punitive measures, prevention, and restorative justice...
January 2018: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29234534/comparison-of-interrupted-and-continuous-suture-urethroplasty-in-tubularised-incised-plate-hypospadias-repair-a-prospective-study
#17
Archika Gupta, Rajesh Gupta, Punit Srivastav, Ankush Gupta
Objective: To compare the effect of interrupted- and continuous-suture urethroplasty on complication rates in Snodgrass tubularised incised-plate (TIP) hypospadias repair. Patients and methods: This was a prospective randomised study comprising 100 boys (age range 1-5 years) with primary subcoronal, distal- and mid-penile hypospadias who underwent repair from October 2010 to March 2015 in a tertiary care hospital. Boys with glanular, recurrent, and proximal hypospadias were excluded from the study...
December 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29227882/kalaban-young-drug-users-engagements-with-law-enforcement-in-the-philippines
#18
Gideon Lasco
BACKGROUND: A violent 'war on drugs' continues to be waged in the Philippines, even as the use of drugs - particular methamphetamine - continues to rise. Furnishing contextual background to the current situation, this paper explores how long-running law enforcement approaches in the Philippines might be viewed by those in their receiving end by presenting findings of an ethnography among marginalized young men. METHODS: Semi-structured interviews and focus group discussions were conducted among 20 young men throughout a 12-month period of participant-observation from December 2011 to September 2013...
December 8, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29200985/the-impact-of-punitive-immigrant-laws-on-the-health-of-latina-o-populations
#19
Edward D Vargas, Gabriel R Sanchez, Melina Juárez
This study examines how anti-immigrant policies affect the physical health of Latina/os in the United States. Merging two unique datasets: sum of anti-immigrant policies by state from 2005-2011 and a 2011 Robert Wood Johnson Center for Health Policy nationally representative sample of Latina/os (n=1,200), we estimate a series of logistic regressions to understand how anti-immigrant legislations are affecting the health of Latina/os. Our modeling approach takes into consideration Latinos' diverse experience, context that is widely overlooked in datasets that treat Latina/os as a homogeneous ethnic group...
June 2017: Politics & Policy
https://www.readbyqxmd.com/read/29194558/nurses-with-substance-use-disorders-where-we-are-and-what-needs-to-be-done
#20
Julie Worley
Nurses have the same rate of substance use disorders (SUDs) as the general public. Management of nurses with SUDs is moving from being punitive, including public license suspension or revocation, to alternative-to-discipline (ATD) programs that focus on early intervention and non-punitive, confidential help, which often involve continued employment. These programs have good retention rates, and nurses who complete them have fewer criminal convictions and are able to retain their nursing licenses and maintain successful careers in nursing...
December 1, 2017: Journal of Psychosocial Nursing and Mental Health Services
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