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https://www.readbyqxmd.com/read/28927987/industry-perspective-on-contemporary-protein-binding-methodologies-considerations-for-regulatory-drug-drug-interaction-and-related-guidelines-on-highly-bound-drugs
#1
REVIEW
Li Di, Christopher Breen, Rob Chambers, Sean T Eckley, Robert Fricke, Avijit Ghosh, Paul Harradine, J Cory Kalvass, Stacy Ho, Caroline A Lee, Punit Marathe, Everett J Perkins, Mark Qian, Susanna Tse, Zhengyin Yan, Maciej J Zamek-Gliszczynski
Regulatory agencies have recently issued drug-drug interaction (DDI) guidelines, which require determination of plasma protein binding (PPB). To err on the conservative side, the agencies recommend that a 0.01 lower limit of fraction unbound (fu) be used for highly bound compounds (>99%), irrespective of the actual measured values. While this may avoid false negatives, the recommendation would likely result in a high rate of false positive predictions, resulting in unnecessary clinical studies and more stringent inclusion/exclusion criteria, which may add cost and time in delivery of new medicines to patients...
September 16, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28915988/learning-to-be-gendered-gender-socialization-in-early-adolescence-among-urban-poor-in-delhi-india-and-shanghai-china
#2
Sharmistha Basu, Xiayun Zuo, Chaohua Lou, Rajib Acharya, Rebecka Lundgren
PURPOSE: The purpose of the study is to understand the gender socialization process in early adolescence. METHODS: The study was located in two disadvantaged urban communities in Delhi, India and Shanghai, China and was part of the multicountry (15) Global Early Adolescent Study. Qualitative methodologies were used with boys and girls aged 11-13 years, including 16 group-based timeline exercises and 65 narrative interviews. In addition, 58 parents of participating adolescents were interviewed...
October 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28914243/an-in-vitro-comparison-of-casein-phosphopeptide-amorphous-calcium-phosphate-paste-casein-phosphopeptide-amorphous-calcium-phosphate-paste-with-fluoride-and-casein-phosphopeptide-amorphous-calcium-phosphate-varnish-on-the-inhibition-of-demineralization-and-promotion
#3
Prachi Jayesh Thakkar, Chandrashekhar M Badakar, Shivayogi M Hugar, Seema Hallikerimath, Punit M Patel, Parin Shah
AIM: This study aims to determine and compare the extent of inhibition of demineralization and promotion of remineralization of permanent molar enamel with and without application of three remineralizing agents. MATERIALS AND METHODS: Forty extracted permanent molars were randomly divided into two groups 1 and 2, longitudinally sectioned into four and divided into subgroups A, B, C, and D. The sections were coated with nail varnish leaving a window of 3 mm × 3 mm...
October 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28910608/strengthening-advocacy-efforts-with-empirical-evidence-a-case-example-of-the-conduct-uptake-and-utilisation-of-research-in-drug-policy-decision-making-in-vietnam
#4
Thu Vuong, Alison Ritter, Nhu Nguyen, Robert Ali
During the last decade, international aid agencies and advocates have been working with Southeast Asian governments to move away from punitive responses towards people who use drugs to more public health, humane approaches. The lack of local scientific evidence about the effectiveness of different treatment approaches has made this advocacy work more challenging. This paper reflects on a generation of treatment research evidence and how it can assist advocacy efforts. The case example is the cost-effectiveness research, comparing centre-based compulsory treatment with community-based voluntary methadone maintenance treatment in Vietnam (2012-2015)...
September 11, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28905731/what-does-health-justice-look-like-for-people-returning-from-incarceration
#5
Lisa Puglisi, Joseph P Calderon, Emily A Wang
Access to health care is a constitutional right in the United States correctional system, and many incarcerated adults are newly diagnosed with chronic diseases in prison. Despite this right, the quality of correctional health care is variable, largely unmeasured and unregulated, and characterized by patients' widespread distrust of a health system that is intimately tied to a punitive criminal justice system. Upon release, discontinuity of care is the norm, and when continuity is established, it is often hindered by distrust, discrimination, poor communication, and racism in the health system...
September 1, 2017: AMA Journal of Ethics
https://www.readbyqxmd.com/read/28881308/overexpression-of-exportin-5-overrides-the-inhibitory-effect-of-mirnas-regulation-control-and-stabilize-proteins-via-posttranslation-modifications-in-prostate-cancer
#6
Naseruddin Höti, Shuang Yang, Paul Aiyetan, Binod Kumar, Yingwei Hu, David Clark, Arife Unal Eroglu, Punit Shah, Tamara Johnson, Wasim H Chowdery, Hui Zhang, Ronald Rodriguez
Although XPO5 has been characterized to have tumor-suppressor features in the miRNA biogenesis pathway, the impact of altered expression of XPO5 in cancers is unexplored. Here we report a novel "oncogenic" role of XPO5 in advanced prostate cancer. Using prostate cancer models, we found that excess levels of XPO5 override the inhibitory effect of the canoncial miRNA-mRNA regulation, resulting in a global increase in proteins expression. Importantly, we found that decreased expression of XPO5 could promote an increase in proteasome degradation, whereas overexpression of XPO5 leads to altered protein posttranslational modification via hyperglycosylation, resulting in cellular protein stability...
September 4, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28876518/externalizing-problem-behavior-in-adolescence-parenting-interacting-with-dat1-and-drd4-genes
#7
Annelies Janssens, Wim Van Den Noortgate, Luc Goossens, Hilde Colpin, Karine Verschueren, Stephan Claes, Karla Van Leeuwen
This study extends previous gene-by-environment (G × E) research through design and methodological advances and examines alternative hypotheses of diathesis stress, vantage sensitivity, and differential susceptibility. In a sample of 984 adolescents and their parents, we examined whether effects of parental support, proactive, punitive, harsh punitive, and psychological control on externalizing problem behavior are moderated by adolescents' genotype for the dopamine transporter (DAT1) or receptor D4 (DRD4) gene...
June 2017: Journal of Research on Adolescence: the Official Journal of the Society for Research on Adolescence
https://www.readbyqxmd.com/read/28875262/erratum-to-asparagine-synthetase-deficiency-report-of-a-novel-mutation-and-review-of-literature
#8
Neerja Gupta, Vishal Vishnu Tewari, Manoj Kumar, Nitika Langeh, Aditi Gupta, Pallavi Mishra, Punit Kaur, Vedam Ramprasad, Sakthivel Murugan, Reema Kumar, Manisha Jana, Madhulika Kabra
No abstract text is available yet for this article.
September 5, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28866305/parental-perception-of-anxiety-in-children-with-eosinophilic-esophagitis-in-a-tertiary-care-center
#9
Jaison Jose, Amy Virojanapa, Erik B Lehman, Alexandra Horwitz, Tracy Fausnight, Punit Jhaveri, Chandran Alexander, Pooja Jhaveri
No abstract text is available yet for this article.
August 30, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28852260/-the-barking-girl-a-case-report-of-psychogenic-cough-in-a-child-with-a-review-of-literature
#10
Praveen Kumar Jakati, Subrata Naskar, Anisha Khanna
A 9-year-old girl presented with 2-month history of continuous coughing; despite detailed evaluation, no organic cause was found. Considering the provisional diagnosis of a psychogenic cough, she was advised for psychiatry consultation. After a psychological assessment, she was found to have comorbid anxiety (Screen for Child Anxiety Related Disorders score- 25) along with punitive parenting and sibling rivalry issues. She was initially treated with parental psychoeducation, play therapy, and behavior therapy...
July 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28844736/structure-and-binding-studies-of-proliferating-cell-nuclear-antigen-from-leishmania-donovani
#11
Satya Prakash Yadav, Prashant Kumar Singh, Pradeep Sharma, Naseer Iqbal, Punit Kaur, Sujata Sharma, Tej P Singh
Proliferating cell nuclear antigen (PCNA) acts as a sliding clamp to support DNA replication and repair. The structure of PCNA from Leishmania donovani (LdPCNA) has been determined at 2.73Å resolution. Structure consists of six crystallographically independent molecules which form two trimeric rings. The pore diameter of the individual trimeric ring is of the order of 37Å. The two rings are stacked through their front to front faces. In order to gain a stable packing, the rings are rotated by 42° about the pore axis and shifted by 7Å and tilted by 16° along the perpendicular direction to pore axis...
August 24, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28833001/dermoscopy-of-borderline-tuberculoid-leprosy
#12
Balachandra S Ankad, Punit S Sakhare
INTRODUCTION: Leprosy is a chronic granulomatous condition caused by Mycobacterium leprae, and borderline tuberculoid (BT) leprosy is the most common type of leprosy and presents with large, well- to ill-defined hypopigmented patches. It is known for atypical presentations. Dermoscopy of granulomatous conditions is well documented. However, there is no description of dermoscopy of BT leprosy in the literature. Authors evaluated the dermoscopic patterns of BT leprosy. CASE REPORT: Patients with BT leprosy were studied for dermoscopic patterns...
August 22, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28825650/an-experiment-assessing-punitive-versus-wellness-framing-of-a-tobacco-free-campus-policy-on-students-perceived-level-of-university-support
#13
Joseph G L Lee, Christopher J Purcell, Beth H Chaney
The objective of this study was to examine how different ways of describing a hypothetical tobacco-free campus policy would impact college students' perceived level of support from the college. In the spring of 2016, we randomized 1885 undergraduate students in a required course to three message conditions in an online survey: control (no message), wellness (emphasizing promoting health and quitting support), and punitive (emphasizing consequences for violating the policy). The dependent variable was perceived organizational support...
August 20, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28806259/serendipitous-discovery-of-isolated-gastric-metastases-from-adenocarcinoma-of-the-lung-on-staging-18f-fdg-pet-ct
#14
Punit Sharma, Amit Dutt Dwary, Enam Murshed Khan
Gastric metastasis from lung cancer is rare. We here present the case of a 59-year-old man with lung adenocarcinoma where isolated gastric metastases were discovered on staging F-FDG PET-CT, confirmed with endoscopy and biopsy.
October 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28799101/determinants-of-punitive-attitudes-toward-people-with-pedophilia-dissecting-effects-of-the-label-and-intentionality-ascriptions
#15
Roland Imhoff, Sara Jahnke
Recent research has established marked punitive attitudes against people sexually interested in children. These negative attitudes are even more pronounced when such sexual interest is labeled as pedophilia, but are attenuated to the extent that such sexual interest is perceived as beyond one's own control (unintentional). We explored these effects in more detail by separately manipulating the label (pedophiles vs. people with sexual interest in prepubescent children) and degree of intentionality (pedophilia or sexual desire as malleable vs...
August 10, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28794237/prolonged-immigration-detention-complicity-and-boycotts
#16
Melanie Jansen, Alanna Sue Tin, David Isaacs
Australia's punitive policy towards people seeking asylum deliberately causes severe psychological harm and meets recognised definitions of torture. Consequently, there is a tension between doctors' obligation not to be complicit in torture and doctors' obligation to provide best possible care to their patients, including those seeking asylum. In this paper, we explore the nature of complicity and discuss the arguments for and against a proposed call for doctors to boycott working in immigration detention. We conclude that a degree of complicity is unavoidable when working in immigration detention, but that it may be ethically justifiable...
August 9, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28776279/asparagine-synthetase-deficiency-report-of-a-novel-mutation-and-review-of-literature
#17
Neerja Gupta, Vishal Vishnu Tewari, Manoj Kumar, Nitika Langeh, Aditi Gupta, Pallavi Mishra, Punit Kaur, Vedam Ramprasad, Sakthivel Murugan, Reema Kumar, Manisha Jana, Madhulika Kabra
Asparagine synthetase deficiency is a rare inborn error of metabolism caused by a defect in ASNS, a gene encoding asparagine synthetase. It manifests with a severe neurological phenotype manifesting as severe developmental delay, congenital microcephaly, spasticity and refractory seizures. To date, nineteen patients from twelve unrelated families have been identified. Majority of the mutations are missense and nonsense mutations in homozygous or compound heterozygous state. We add another case from India which harbored a novel homozygous missense variation in exon 11 and compare the current case with previously reported cases...
August 3, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28764780/improving-patient-safety-culture-in-saudi-arabia-2012-2015-trending-improvement-and-benchmarking
#18
Khalid Alswat, Rawia Ahmad Mustafa Abdalla, Maher Abdelraheim Titi, Maram Bakash, Faiza Mehmood, Beena Zubairi, Diana Jamal, Fadi El-Jardali
BACKGROUND: Measuring patient safety culture can provide insight into areas for improvement and help monitor changes over time. This study details the findings of a re-assessment of patient safety culture in a multi-site Medical City in Riyadh, Kingdom of Saudi Arabia (KSA). Results were compared to an earlier assessment conducted in 2012 and benchmarked with regional and international studies. Such assessments can provide hospital leadership with insight on how their hospital is performing on patient safety culture composites as a result of quality improvement plans...
August 2, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28764407/coexisting-synchronous-and-asynchronous-states-in-locally-coupled-array-of-oscillators-by-partial-self-feedback-control
#19
Bidesh K Bera, Dibakar Ghosh, Punit Parmananda, G V Osipov, Syamal K Dana
We report the emergence of coexisting synchronous and asynchronous subpopulations of oscillators in one dimensional arrays of identical oscillators by applying a self-feedback control. When a self-feedback is applied to a subpopulation of the array, similar to chimera states, it splits into two/more sub-subpopulations coexisting in coherent and incoherent states for a range of self-feedback strength. By tuning the coupling between the nearest neighbors and the amount of self-feedback in the perturbed subpopulation, the size of the coherent and the incoherent sub-subpopulations in the array can be controlled, although the exact size of them is unpredictable...
July 2017: Chaos
https://www.readbyqxmd.com/read/28764297/comparative-assessment-of-conventional-composites-and-coloured-compomers-in-permanent-molars-of-children-with-mixed-dentition-a-pilot-study
#20
Shivayogi M Hugar, Divyata Kohli, Chandrashekhar M Badakar, Supriya S Vyavahare, Parin P Shah, Niraj S Gokhale, Punit M Patel, Madhura V Mundada
INTRODUCTION: Early treatment of carious lesions in children is important for the maintenance of oral health. Multicoloured restorations could be the impetus for an extremely nervous or defiant child to take dental treatment. AIM: The aim of this study was to assess and compare the clinical success of conventional composites and coloured compomer material in first permanent molars of children with mixed dentition. MATERIALS AND METHODS: A total of sixty sites, divided into two groups, with thirty subjects in each group using split mouth design were chosen amongst patients reporting to Department of Pedodontics and Preventive Dentistry...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
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