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https://www.readbyqxmd.com/read/29142363/multiple-colorectal-adenomas-syndrome-with-malignant-degeneration-in-multiple-colorectal-polyps-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-findings
#1
Punit Sharma
Multiple colorectal adenomas (MCRAs) syndrome is a genetic syndrome characterized by multiple colorectal polyps. Patients usually present late in late fourth or fifth decade of life. They have a high risk for developing malignancy. We here present such case of a 61-year-old man with MCRAs who developed malignant degeneration of multiple colorectal polyps, which was demonstrated on (18)F-fluorodeoxyglucose positron emission tomography-computed tomography.
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29141452/quality-characteristics-of-sauerkraut-fermented-by-using-a-lactobacillus-paracasei-starter-culture-grown-in-tofu-whey
#2
Olatunji T Joyce, Subir K Chakraborty, Manoj K Tripathi, Nachiket Kotwaliwale, Punit Chandra
The quality parameters of sauerkraut fermented using Lactobacillus paracasei in terms of its lactic acid bacteria count, texture, colour and biochemical properties were studied. As a starter culture L. paracasei grown in tofu whey was used for sauerkraut fermentation. The experiments were planned using central composite rotatable design of response surface methodology for input variables - culture volume (ml), fermentation time (days) and salt concentration (g/100 g). The linear and interactive effect of variables on responses was understood by statistically significant (p < 0...
January 1, 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/29112011/role-of-various-metabolic-parameters-derived-from-baseline-18f-fdg-pet-ct-as-prognostic-markers-in-non-small-cell-lung-cancer-patients-undergoing-platinum-based-chemotherapy
#3
Akshima Sharma, Anant Mohan, Ashu Seith Bhalla, Mehar Chand Sharma, Sreenivas Vishnubhatla, Chandan J Das, Anil Kumar Pandey, Chandra Sekhar Bal, Chetan D Patel, Punit Sharma, Krishan Kant Agarwal, Rakesh Kumar
PURPOSE: The aim of this study was to prospectively evaluate the role of various quantitative and semiquantitative metabolic parameters derived from dynamic and static baseline F-FDG PET/CT in prediction of overall survival (OS) in non-small cell lung cancer (NSCLC) patients who were planned to undergo platinum-based chemotherapy. METHODS: Sixty patients (51 male and 9 female patients) with biopsy-proven NSCLC and mean age 59.55 ± 10.06 years who were planned to undergo platinum-based chemotherapy were enrolled in the study...
November 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29110553/the-punitive-woman-gender-differences-in-public-attitudes-toward-parole-among-an-australian-sample
#4
Shannon Dodd
Research exploring gender differences in public attitudes toward parole is limited, despite a large body of literature showing that men and women have diverging views on other criminal justice issues, including capital punishment and offender rehabilitation and treatment. Drawing on an Australian national survey of community views on parole, the current study examines whether men and women differ in their support for the release of prisoners on parole. The results indicate that gender does predict parole attitudes, with Australian women significantly more likely to hold nonsupportive views on parole than Australian men...
November 1, 2017: International Journal of Offender Therapy and Comparative Criminology
https://www.readbyqxmd.com/read/29104390/an-in-vitro-comparative-evaluation-of-efficacy-of-disinfecting-ability-of-garlic-oil-neem-oil-clove-oil-and-tulsi-oil-with-autoclaving-on-endodontic-k-files-tested-against-enterococcus-faecalis
#5
Shivayogi Hugar, Punit M Patel, Jyoti Nagmoti, Chaitanya Uppin, Laresh Mistry, Neha Dhariwal
Aim: To comparatively evaluate the efficacy of disinfecting ability of garlic oil, neem oil, clove oil, and tulsi oil with autoclaving on endodontic K files tested against Enterococcus faecalis. Materials and methods: Fifty endodontic K files were exposed to the test micro-organism and checked for its disinfecting ability using three different methods. Result: Garlic oil, clove oil, tulsi oil and autoclave showed considerable effectiveness against E...
July 2017: International Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29081434/entitled-to-addiction-pharmaceuticals-race-and-america-s-first-drug-war
#6
David Herzberg
This article rethinks the formative decades of American drug wars through a social history of addiction to pharmaceutical narcotics, sedatives, and stimulants in the first half of the twentieth century. It argues, first, that addiction to pharmaceutical drugs is no recent aberration; it has historically been more extensive than "street" or illicit drug use. Second, it argues that access to psychoactive pharmaceuticals was a problematic social entitlement constructed as distinctively medical amid the racialized reforms of the Progressive Era...
2017: Bulletin of the History of Medicine
https://www.readbyqxmd.com/read/29069408/asialoglycoprotein-receptor-1-mediates-productive-uptake-of-n-acetylgalactosamine-conjugated-and-unconjugated-phosphorothioate-antisense-oligonucleotides-into-liver-hepatocytes
#7
Michael Tanowitz, Lisa Hettrick, Alexey Revenko, Garth A Kinberger, Thazha P Prakash, Punit P Seth
Antisense oligonucleotide (ASO) therapeutics show tremendous promise for the treatment of previously intractable human diseases but to exert their effects on cellular RNA processing they must first cross the plasma membrane by endocytosis. The conjugation of ASOs to a receptor ligand can dramatically increase their entry into certain cells and tissues, as demonstrated by the implementation of N -acetylgalactosamine (GalNAc)-conjugated ASOs for Asialoglycoprotein Receptor (ASGR)-mediated uptake into liver hepatocytes...
October 23, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29067831/social-and-structural-factors-increase-inconsistent-condom-use-by-sex-workers-one-time-and-regular-clients-in-northern-uganda
#8
Putu Duff, Josephine Birungi, Sabina Dobrer, Monika Akello, Godfrey Muzaaya, Kate Shannon
While sex workers (SWs) bear the brunt of the epidemic in Uganda, there remains a dearth of empirical research on the structural drivers of HIV prevention among SWs. This study examined the drivers of inconsistent condom use by one-time and regular clients of young women SWs in Gulu, Northern Uganda. Data were drawn from the Gulu Sexual Health Study, a cross-sectional study of young SWs, aged 14 years and older (2011-2012). SWs were recruited using peer/SW-led outreach, in partnership with The AIDS Support Organization and other CBOs...
October 25, 2017: AIDS Care
https://www.readbyqxmd.com/read/29052614/narp-mediates-antidepressant-like-effects-of-electroconvulsive-seizures
#9
Andrew D Chang, Punit V Vaidya, Edward P Retzbach, Sunho J Chung, Urian Kim, Kathryn Baselice, Kristen Maynard, Alec Stepanian, Melissa Staley, Lan Xiao, Ashley Blouin, Sungho Han, JongAh Lee, Paul F Worley, Kellie L Tamashiro, Barbara L Hempstead, Keri Martinowich, Mary Ann Wilson, Jay M Baraban, Irving M Reti
Growing recognition of persistent cognitive defects associated with electroconvulsive therapy (ECT), a highly effective and commonly used antidepressant treatment, has spurred interest in identifying its mechanism of action to guide development of safer treatment options. However, as repeated seizure activity elicits a bewildering array of electrophysiological and biochemical effects, this goal has remained elusive. We have examined whether deletion of Narp, an immediate early gene induced by electroconvulsive seizures (ECS), blocks its antidepressant efficacy...
October 20, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29052041/suicide-of-isolated-inmates-suffering-from-psychiatric-disorders-when-a-preventive-measure-becomes-punitive
#10
S Grassi, G Mandarelli, M Polacco, G Vetrugno, A G Spagnolo, Fabio De-Giorgio
We performed external autopsies and examinations on two inmates who had committed suicide by hanging themselves with their underwear and using the window bars of their cells as ligature points after they had been placed in solitary confinement. In one case, the inmate had even been deprived of her clothing (with the exception to her underwear). Underwear has been rarely described as a means for self-harm and, to the best of our knowledge, no previous study has focused on cases of prison suicides committed using this garment, even though it is available to every inmate...
October 19, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/29039293/conflict-and-cooperation-in-paranoia-a-large-scale-behavioural-experiment
#11
N J Raihani, V Bell
BACKGROUND: Paranoia involves thoughts and beliefs about the harmful intent of others but the social consequences have been much less studied. We investigated whether paranoia predicts maladaptive social behaviour in terms of cooperative and punitive behaviour using experimental game theory paradigms, and examined whether reduced cooperation is best explained in terms of distrust as previous studies have claimed. METHODS: We recruited a large population sample (N = 2132) online...
October 17, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29033992/patient-safety-culture-in-intensive-care-units-from-the-perspective-of-nurses-a-cross-sectional-study
#12
Sedigheh Farzi, Azam Moladoost, Masoud Bahrami, Saba Farzi, Reza Etminani
BACKGROUND: One of the goals of nursing is providing safe care, prevention of injury, and health promotion of patients. Patient safety in intensive care units is threatened for various reasons. This study aimed to survey patient safety culture from the perspective of nurses in intensive care units. MATERIALS AND METHODS: This cross-sectional study was conducted in 2016. Sampling was done using the convenience method. The sample consisted of 367 nurses working in intensive care units of teaching hospitals affiliated to Isfahan University of Medical Sciences...
September 2017: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/29024977/safer-paediatric-surgical-teams-a-5-year-evaluation-of-crew-resource-management-implementation-and-outcomes
#13
Carl Savage, F Andrew Gaffney, Laith Hussain-Alkhateeb, Pia Olsson Ackheim, Gunilla Henricson, Irini Antoniadou, Mats Hedsköld, Karin Pukk Härenstam
Objective: Evaluate longitudinal changes in technical and non-technical skills (teamwork, situation monitoring, communication and leadership), safety culture, and clinical outcomes before and after implementation of a crew resource management (CRM) safety program. Design: A multi-level prospective single case study in accordance with the SQUIRE-guidelines for reporting quality improvement efforts. Setting: Large university paediatric surgical service...
September 7, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29023522/microencapsulation-of-clostridium-difficile-specific-bacteriophages-using-microfluidic-glass-capillary-devices-for-colon-delivery-using-ph-triggered-release
#14
Gurinder K Vinner, Goran T Vladisavljević, Martha R J Clokie, Danish J Malik
The prevalence of pathogenic bacteria acquiring multidrug antibiotic resistance is a global health threat to mankind. This has motivated a renewed interest in developing alternatives to conventional antibiotics including bacteriophages (viruses) as therapeutic agents. The bacterium Clostridium difficile causes colon infection and is particularly difficult to treat with existing antibiotics; phage therapy may offer a viable alternative. The punitive environment within the gastrointestinal tract can inactivate orally delivered phages...
2017: PloS One
https://www.readbyqxmd.com/read/29019117/physiologically-based-pharmacokinetic-modeling-of-transporter-mediated-hepatic-clearance-and-liver-partitioning-of-oatp-and-oct-substrates-in-cynomolgus-monkeys
#15
Bridget L Morse, Jamus G MacGuire, Anthony M Marino, Yue Zhao, Maxine Fox, Yueping Zhang, Hong Shen, W Griffith Humphreys, Punit Marathe, Yurong Lai
In the present investigations, we evaluate in vitro hepatocyte uptake and partitioning for the prediction of in vivo clearance and liver partitioning. Monkeys were intravenously co-dosed with rosuvastatin and bosentan, substrates of the organic anion transporting polypeptides (OATPs), and metformin, a substrate of organic cation transporter 1 (OCT1). Serial plasma and liver samples were collected over time. Liver and plasma unbound fraction was determined using equilibrium dialysis. In vivo unbound partitioning (Kpu,u) for rosuvastatin, bosentan, and metformin, calculated from total concentrations in the liver and plasma, were 243, 553, and 15, respectively...
November 2017: AAPS Journal
https://www.readbyqxmd.com/read/29016712/forty-years-of-state-alcohol-and-pregnancy-policies-in-the-usa-best-practices-for-public-health-or-efforts-to-restrict-women-s-reproductive-rights
#16
Sarah C M Roberts, Sue Thomas, Ryan Treffers, Laurie Drabble
Aims: Alcohol consumption during pregnancy remains a public health problem despite >40 years of attention. Little is known about how state policies have evolved and whether policies represent public health goals or efforts to restrict women's reproductive rights. Methods: Our data set includes US state policies from 1970 through 2013 obtained through original legal research and from the National Institute for Alcohol Abuse and Alcoholism's (NIAAA)'s Alcohol Policy Information System...
November 1, 2017: Alcohol and Alcoholism: International Journal of the Medical Council on Alcoholism
https://www.readbyqxmd.com/read/29016103/comparison-of-enrichment-methods-for-intact-n-and-o-linked-glycopeptides-using-strong-anion-exchange-and-hydrophilic-interaction-liquid-chromatography
#17
Weiming Yang, Punit Shah, Yingwei Hu, Shadi Toghi Eshghi, Shisheng Sun, Yang Liu, Hui Zhang
Heterogeneity of protein glycosylation poses great challenges for analysis that is key to understand structure and function of glycoproteins. Resolving this conundrum requires efficient and specific enrichment of intact glycopeptides for identification and quantitation. To this end, hydrophilic interaction chromatography (HILIC) has been commonly used to enrich intact N- and O-linked glycopeptides. However, its effectiveness to enrich isobarically labeled glycopeptides remains unclear. Here, we studied three different enrichment methods for enrichment of N- and O-linked glycopeptides...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28983326/inter-trial-coherence-of-medial-frontal-theta-oscillations-linked-to-differential-feedback-processing-in-youth-and-young-adults-with-autism
#18
Stefon van Noordt, Jia Wu, Archana Venkataraman, Michael J Larson, Mikle South, Michael J Crowley
BACKGROUND: Impairment in prediction and appreciation for choice outcomes could contribute to several core symptoms of ASD. We examined electroencephalography (EEG) oscillations in 27 youth and young adults diagnosed with autism spectrum disorder (ASD) and 22 IQ-matched neurotypical controls while they performed a chance-based reward prediction task. METHOD: We re-analyzed our previously published ERP data (Larson et al., 2011) and examined theta band oscillations (4-8 Hz) at frontal midline sites, within a timing window that overlaps with the feedback-related negativity (FRN)...
May 2017: Research in Autism Spectrum Disorders
https://www.readbyqxmd.com/read/28971618/higher-patient-satisfaction-with-antidepressants-correlates-with-earlier-drug-release-dates-across-online-user-generated-medical-databases
#19
Scott Siskind, Roland C Aydin, Punit Matta, Christian J Cyron
Studies establishing the use of new antidepressants often rely simply on proving efficacy of a new compound, comparing against placebo and single compound. The advent of large online databases in which patients themselves rate drugs allows for a new Big Data-driven approach to compare the efficacy and patient satisfaction with sample sizes exceeding previous studies. Exemplifying this approach with antidepressants, we show that patient satisfaction with a drug anticorrelates with its release date with high significance, across different online user-driven databases...
October 2017: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28969274/comparison-of-the-effect-of-fluoride-varnish-chlorhexidine-varnish-and-casein-phosphopeptide-amorphous-calcium-phosphate-cpp-acp-varnish-on-salivary-streptococcus-mutans-level-a-six-month-clinical-study
#20
Punit Manish Patel, Shivayogi M Hugar, Seema Halikerimath, Chandrashekhar M Badakar, Niraj S Gokhale, Prachi J Thakkar, Divyata Kohli, Shreyas Shah
INTRODUCTION: Dental caries is the most widespread disease which has a multi factorial origin. Streptococcus mutans is considered to be the chief pathogen in its development. Different varnishes are available which can be used for the prevention of the carious process. AIM: To compare the effect of fluoride varnish, chlorhexidine varnish and fluoride varnish containing Casein Phosphopeptide - Amorphous Calcium Phosphate (CPP-ACP) on salivary Streptococcusmutans count in children with mixed dentition over a period of six months...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
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