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https://www.readbyqxmd.com/read/28630898/polymeric-lithography-editor-editing-lithographic-errors-with-nanoporous-polymeric-probes
#1
Pradeep Ramiah Rajasekaran, Chuanhong Zhou, Mallika Dasari, Kay-Obbe Voss, Christina Trautmann, Punit Kohli
A new lithographic editing system with an ability to erase and rectify errors in microscale with real-time optical feedback is demonstrated. The erasing probe is a conically shaped hydrogel (tip size, ca. 500 nm) template-synthesized from track-etched conical glass wafers. The "nanosponge" hydrogel probe "erases" patterns by hydrating and absorbing molecules into a porous hydrogel matrix via diffusion analogous to a wet sponge. The presence of an interfacial liquid water layer between the hydrogel tip and the substrate during erasing enables frictionless, uninterrupted translation of the eraser on the substrate...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28629304/board-of-pharmacy-practices-related-to-medication-errors-and-their-potential-impact-on-patient-safety
#2
Daniel D Degnan, John B Hertig, Michael J Peters, James G Stevenson
State boards of pharmacy are generally responsible for the governance of the practice of pharmacy. While the regulatory process and methods for accomplishing this task may vary by state, all boards of pharmacy must address medication errors committed by pharmacists. The National Association of Boards of Pharmacy (NABP) has recommended that state boards of pharmacy implement best practices and enforcement actions that are aimed to promote patient safety and reduce medication errors. The current study was designed to identify and compare current corrective action practices among boards of pharmacy in response to medication errors...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28627880/site-specific-fucosylation-analysis-identifies-glycoproteins-associated-with-aggressive-prostate-cancer-cell-lines-using-tandem-affinity-enrichments-of-intact-glycopeptides-followed-by-mass-spectrometry
#3
Jianliang Zhou, Weiming Yang, Yingwei Hu, Naseruddin Hoti, Yang Liu, Punit Shah, Shisheng Sun, David J Clark, Stefani N Thomas, Hui Zhang
Fucosylation (Fuc) of glycoproteins plays an important role in regulating protein function and has been associated with the development of several cancer types including prostate cancer (Pca). Therefore, the research of Fuc glycoproteins has attracted increasing attention recently in analytical field. Herein, a strategy based on lectin affinity enrichments of intact glycopeptides followed by mass spectrometry has been established to evaluate the specificities of various Fuc-binding lectins for glycosite-specific Fuc analysis of non-aggressive (NAG) and aggressive (AG) Pca cell lines...
June 19, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28624665/protecting-the-public-an-investigation-of-midwives-perceptions-of-regulation-and-the-regulator
#4
Jacqueline Wier
OBJECTIVE: to investigate the perceptions of a group of midwifery registrants about the influence of regulation and the regulatory body, the Nursing and Midwifery Council, on the practice of midwives in the United Kingdom DESIGN: quantitative and qualitative research using an online survey and semi-structured interviews SETTING: The South East of England, which covers both urban and rural practice settings. PARTICIPANTS: (a) 132 (n=70%) midwives responded to the online survey, and (b) 20 midwives participated in the semi-structured interviews FINDINGS: midwives were generally supportive of the need to regulate practice; however, some participants had an uneasy relationship with the Nursing and Midwifery Council and claimed to practice defensively, due to a fear that they could be removed from the register, and believed the regulator to be remote and punitive...
June 6, 2017: Midwifery
https://www.readbyqxmd.com/read/28624195/fluorinated-nucleotide-modifications-modulate-allele-selectivity-of-snp-targeting-antisense-oligonucleotides
#5
Michael E Østergaard, Josh Nichols, Timothy A Dwight, Walt Lima, Michael E Jung, Eric E Swayze, Punit P Seth
Antisense oligonucleotides (ASOs) have the potential to discriminate between subtle RNA mismatches such as SNPs. Certain mismatches, however, allow ASOs to bind at physiological conditions and result in RNA cleavage mediated by RNase H. We showed that replacing DNA nucleotides in the gap region of an ASO with other chemical modification can improve allele selectivity. Herein, we systematically substitute every position in the gap region of an ASO targeting huntingtin gene (HTT) with fluorinated nucleotides...
June 16, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28617946/heterogeneity-in-perceptions-of-parenting-among-arab-refugee-adolescents-in-jordan
#6
Judith G Smetana, Ikhlas Ahmad
Heterogeneity in parenting was examined in 883 Arab refugee adolescents in Jordan (Mage  = 15.01 years, SD = 1.60). Latent profile analyses of five parenting dimensions rated separately for mothers and fathers yielded authoritative, authoritarian, indifferent, punitive, and for mothers, permissive profiles, with most mothers (60%) and fathers (66%) classified as authoritative. Parenting was more often authoritative for women than men and punitive (for fathers) or permissive (for mothers) of boys than girls...
June 15, 2017: Child Development
https://www.readbyqxmd.com/read/28605946/design-and-characterization-of-a-phased-antenna-array-for-intact-breast-hyperthermia
#7
Sergio Curto, Aleix Garcia-Miquel, Minyoung Suh, Neus Vidal, Jose M Lopez-Villegas, Punit Prakash
PURPOSE: Currently available hyperthermia technology is not well suited to treating cancer malignancies in the intact breast. This study investigates a microwave applicator incorporating multiple patch antennas, with the goal of facilitating controllable power deposition profiles for treating lesions at diverse locations within the intact breast. MATERIALS AND METHODS: A 3D-computational model was implemented to assess power deposition profiles with 915 MHz applicators incorporating a hemispheric groundplane and configurations of 2, 4, 8, 12, 16 and 20 antennas...
June 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28599765/don-t-ask-or-tell-pay-secrecy-policies-in-u-s-workplaces
#8
Jake Rosenfeld
How widespread are workplace rules against discussing wages and salaries in the U.S.? And what are the core correlates of whether or not an employer prohibits or discourages this type of speech? Using a unique dataset that includes a measure of whether workers are prohibited or discouraged from discussing pay, this article investigates the prevalence of pay secrecy policies, and what worker- and workplace-level characteristics are associated with these rules. Key findings reveal that these policies are commonplace, despite being illegal, and that they are concentrated in more "coercive" rather than "enabling" organizations...
July 2017: Social Science Research
https://www.readbyqxmd.com/read/28599742/assessing-marijuana-use-during-pregnancy
#9
Allyssa L Harris, Chiamaka S Okorie
Recreational and medicinal marijuana uses have become more prevalent in recent years. Women's health nurses are increasingly likely to encounter pregnant women who use or have used marijuana. Research has found that inadequate screening for substance use, inadequate knowledge about the effects of marijuana use, and punitive counseling are barriers to women's understanding of the importance of seeking treatment for substance use. Provision of evidence-based counseling, education, and resources support women and strengthen the patient-provider relationship...
June 2017: Nursing for Women's Health
https://www.readbyqxmd.com/read/28592485/energetics-of-side-chain-partitioning-of-%C3%AE-signal-residues-in-unassisted-folding-of-a-transmembrane-%C3%AE-barrel-protein
#10
Bharat Ramasubramanian Iyer, Punit Zadafiya, Pallavi Vijay Vetal, Radhakrishnan Mahalakshmi
The free energy of water-to-interface amino acid partitioning is a major contributing factor in membrane protein folding and stability. The interface residues at the C-terminus of transmembrane β-barrels form the β-signal motif required for assisted β-barrel assembly in vivo, but are believed to be less important for β-barrel assembly in vitro Here, we experimentally measured the thermodynamic contribution of all 20 amino acids at the β-signal motif to the unassisted folding of the model β-barrel protein PagP...
June 7, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28585156/sex-work-criminalization-is-barking-up-the-wrong-tree
#11
Ine Vanwesenbeeck
There is a notable shift toward more repression and criminalization in sex work policies, in Europe and elsewhere. So-called neo-abolitionism reduces sex work to trafficking, with increased policing and persecution as a result. Punitive "demand reduction" strategies are progressively more popular. These developments call for a review of what we know about the effects of punishing and repressive regimes vis-à-vis sex work. From the evidence presented, sex work repression and criminalization are branded as "waterbed politics" that push and shove sex workers around with an overload of controls and regulations that in the end only make things worse...
June 5, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/28576766/comparative-evaluation-of-plasma-bile-acids-dehydroepiandrosterone-sulfate-hexadecanedioate-and-tetradecanedioate-with-coproporphyrins-i-and-iii-as-markers-of-oatp-inhibition-in-healthy-subjects
#12
Hong Shen, Weiqi Chen, Dieter M Drexler, Sandhya Mandlekar, Vinay K Holenarsipur, Eric E Shields, Robert Langish, Kurex Sidik, Jinping Gan, W Griffith Humphreys, Punit Marathe, Yurong Lai
Multiple endogenous compounds have been proposed as candidate biomarkers to monitor organic anion transporting polypeptide (OATP) function in preclinical species or humans. Recently we have demonstrated that coproporphyrins (CPs) I and III are appropriate clinical markers to evaluate OATP inhibition and recapitulate clinical drug-drug interactions (DDIs). In the present studies, we investigated bile acids (BAs), dehydroepiandrosterone sulfate (DHEAS), hexadecanedioate (HDA), and tetradecanedioate (TDA) in plasma as endogenous probes for OATP inhibition and compared these candidate probes to CPs...
June 2, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28571287/surgical-management-of-a-rare-case-of-massive-compound-odontome-associated-with-missing-primary-tooth
#13
Elengkumaran Sankaran, Sangeetha Narasimhan, K S Sabitha, Punit Chitlangia
Odontomes are considered to be the most common odontogenic tumours of the jaws. They are benign, mixed tumours arising from the remnants of both odontogenic epithelium and the ectomesenchyme resulting in the deposition of varied propotions of enamel, dentin, cementum and pulp tissues. As these lesions show deficiency only in structural arrangement, some authors consider odontomes as hamartomas or tumour like malformations. Though these lesions are more common in children, very few cases have been reported in less than five years age group...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28558358/scl-90-r-emotional-distress-ratings-in-substance-use-and-impulse-control-disorders-one-factor-oblique-first-order-higher-order-and-bi-factor-models-compared
#14
Willem A Arrindell, Róbert Urbán, Danilo Carrozzino, Per Bech, Zsolt Demetrovics, Hendrik G Roozen
To fully understand the dimensionality of an instrument in a certain population, rival bi-factor models should be routinely examined and tested against oblique first-order and higher-order structures. The present study is among the very few studies that have carried out such a comparison in relation to the Symptom Checklist-90-R. In doing so, it utilized a sample comprising 2593 patients with substance use and impulse control disorders. The study also included a test of a one-dimensional model of general psychological distress...
May 19, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28546665/proposing-a-hybrid-model-based-on-robson-s-classification-for-better-impact-on-trends-of-cesarean-deliveries
#15
Punit Hans, Renu Rohatgi
AIM AND OBJECTIVES: To construct a hybrid model classification for cesarean section (CS) deliveries based on the woman-characteristics (Robson's classification with additional layers of indications for CS, keeping in view low-resource settings available in India). METHODS: This is a cross-sectional study conducted at Nalanda Medical College, Patna. All the women delivered from January 2016 to May 2016 in the labor ward were included. Results obtained were compared with the values obtained for India, from secondary analysis of WHO multi-country survey (2010-2011) by Joshua Vogel and colleagues' study published in "The Lancet Global Health...
June 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28546632/bonfire-of-the-verities
#16
P Batchelor
The emphasis on ensuring improved governance within the UK dental care system continues to rely on the identification of poorly performing individuals. Such an approach, while addressing certain political expediencies, fails to take into account both the wider system issues and the extensive literature on how to influence performance in a positive way. If sustainable improvements in the qualities of care are to occur, an acknowledgement of the system's shortcomings by the main parties must be made and where individual performance has fallen below that regarded as acceptable, the contribution of the delivery system in general needs to be noted...
May 26, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28543540/computational-modeling-of-915-mhz-microwave-ablation-comparative-assessment-of-temperature-dependent-tissue-dielectric-models
#17
Garron Deshazer, Mark Hagmann, Derek Merck, Jan Sebek, Kent B Moore, Punit Prakash
PURPOSE: The objective of this study is to develop a computational model for simulating 915 MHz microwave ablation (MWA), and verify the simulation predictions of transient temperature profiles against experimental measurements. Due to the limited experimental data characterizing temperature-dependent changes of tissue dielectric properties at 915 MHz, we comparatively assess two temperature dependent approaches of modeling of dielectric properties: model A- piecewise linear temperature dependencies based on existing, but limited, experimental data, and model B- similar to model A, but augmented with linear decrease in electrical conductivity above 95 °C, as guided by our experimental measurements...
May 23, 2017: Medical Physics
https://www.readbyqxmd.com/read/28528172/cannabis-and-pregnancy-maternal-child-health-implications-during-a-period-of-drug-policy-liberalization
#18
Katrina Mark, Mishka Terplan
Cannabis use is common and increasing among women in the United States. State policies are changing with a movement towards decriminalization and legalization. We explore the implications of cannabis liberalization for maternal and child health. Most women who use cannabis quit or cut back during pregnancy. Although women are concerned about the possible health effects of cannabis, providers do a poor job of counseling. There is a theoretical potential for cannabis to interfere with neurodevelopment, however human data have not identified any long-term or long lasting meaningful differences between children exposed in utero to cannabis and those not...
May 18, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28525457/stensen-duct-relapse-of-diffuse-large-b-cell-lymphoma-an-unusual-pattern-detected-with-18f-fdg-pet-ct
#19
Punit Sharma, Shilpa Bhartia
F-FDG PET/CT is now an established modality for staging and restaging high-grade lymphomas, including diffuse large B-cell lymphoma. We here present the case of a 51-year-old woman successfully treated for diffuse large B-cell lymphoma. Follow-up F-FDG PET/CT demonstrated an unusual site of relapse involving left Stensen (parotid) duct, which was confirmed with cytology. By identifying such unusual sites of lymphomatous involvement, F-FDG PET/CT can have significant bearing on patient management.
July 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28516855/victim-impact-statements-how-victim-social-class-affects-juror-decision-making
#20
Kimberly Schweitzer, Narina Nuñez
Although the Supreme Court has ruled that victim impact statements (VIS) should be allowed at trial, the concern voicedin Payne v. Tennessee (1991) and Furman v. Georgia (1972) was that VIS might enable jurors to make comparative judgments about the worth of the victim. This study examined the effect VIS and low and middle socioeconomic status (SES) victims have on jurors' decisions. Mock jurors listened to 1 of 3 audio recordings of the sentencing phase of a capital murder trial (no VIS, low SES VIS, or middle SES VIS) and were asked to sentence the defendant to either life in prison without parole or death...
May 17, 2017: Violence and Victims
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