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Anshul Chaudhary, Vinod Kumar, Prashant K Singh, Pradeep Sharma, Hridoy R Bairagya, Punit Kaur, Sujata Sharma, Shyam S Chauhan, Tej P Singh
Secretory signalling glycoprotein (SPX-40) from mammary gland is highly expressed during involution. This protein is involved in a programmed cell death during tissue remodelling which occurs at the end of lactation. SPX-40 was isolated and purified from buffalo (SPB-40) from the samples obtained during involution. One solution of SPB-40 was made by dissolving it in buffer containing 25 mM Tris-HCl and 50 mM NaCl at pH 8.0. Another solution was made by adding 25% ethanol to the above solution. The biological effects of SPB-40 dissolved in above two solutions were evaluated on MCF-7 breast cancer cell lines...
March 7, 2018: Archives of Biochemistry and Biophysics
Geetanjali Arora, Punit Sharma, Anshul Sharma, Anil Kumar Mishra, Puja Panwar Hazari, Ahitagni Biswas, Ajay Garg, Deepak Aheer, Rakesh Kumar
OBJECTIVES: Posttherapy changes in treated glioma patients cannot be reliably differentiated from tumor recurrence. We evaluated the role of Tc-methionine SPECT/CT for the detection of recurrent glioma and compared the same with F-FDG PET/CT and contrast-enhanced MRI (CeMRI). METHODS: Forty-four patients with histologically proven, previously treated glioma and clinical suspicion of recurrence were prospectively enrolled in the study. Of these 44 patients, 39 (28 male and 11 female subjects; age, 38...
March 7, 2018: Clinical Nuclear Medicine
Benjamin Grant Purzycki, Cody T Ross, Coren Apicella, Quentin D Atkinson, Emma Cohen, Rita Anne McNamara, Aiyana K Willard, Dimitris Xygalatas, Ara Norenzayan, Joseph Henrich
Researchers have recently proposed that "moralistic" religions-those with moral doctrines, moralistic supernatural punishment, and lower emphasis on ritual-emerged as an effect of greater wealth and material security. One interpretation appeals to life history theory, predicting that individuals with "slow life history" strategies will be more attracted to moralistic traditions as a means to judge those with "fast life history" strategies. As we had reservations about the validity of this application of life history theory, we tested these predictions with a data set consisting of 592 individuals from eight diverse societies...
2018: PloS One
Amy L Haycraft
Opioid use disorder (OUD) in pregnancy is increasing, which often results in poor maternal and neonatal outcomes including neonatal abstinence syndrome (NAS) as a result of lack of prenatal care and inadequate substance use disorder management. Practice guidelines have been developed to manage OUD during and after pregnancy for mother and baby, but barriers exist, limiting comprehensive implementation. To reduce the impact of OUD in pregnancy and associated maternal and neonatal sequela, implementing compassionate evidence-based care and a non-punitive response is needed...
March 1, 2018: Journal of Psychosocial Nursing and Mental Health Services
Paulo Ventura, Lucy Anne Livingston, Punit Shah
No abstract text is available yet for this article.
January 1, 2018: Quarterly Journal of Experimental Psychology: QJEP
Amit Katiyar, Sujata Sharma, Tej P Singh, Punit Kaur
Women with endometriosis (EMS) appear to be at a higher risk of developing other autoimmune diseases predominantly multiple sclerosis (MS). Though EMS and MS are evidently diverse in their phenotype, they are linked by a common autoimmune condition or immunodeficiency which could play a role in the expansion of endometriosis and possibly increase the risk of developing MS in women with EMS. However, the common molecular links connecting EMS with MS are still unclear. We conducted a meta-analysis of microarray experiments focused on EMS and MS with their respective controls...
2018: Frontiers in Genetics
Katherine T Flynn Bolte, Rajesh Prabhu Balaraman, Kexin Jiao, Michael D Tustison, Kiah S Kirkwood, Chuanhong Zhou, Punit Kohli
Liquid-solid (LS) and vapor-liquid-solid (VLS) interfaces are important to the fundamental understanding of how surface chemistry impacts industrial processes and applications. Superhydrophobic surfaces, from structural hierarchies, were fabricated by coating flat smooth surfaces with hollow glass microspheres. These surfaces are referred to as structural hierarchical modified microsphere surfaces (SHiMMs). Two phase LS and three-phase VLS interfaces of water droplets on SHiMMs, with an apparent static contact angle (aSCA) of ~160° were probed at microscale using environmental scanning electron microscopy (ESEM) and high resolution optical microscopy (OM)...
February 28, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Vivienne M Colegrove, Sophie S Havighurst, Christiane E Kehoe, Stine L Jacobsen
For parents who have experienced childhood interpersonal trauma, the challenges of parenting an adolescent may trigger memories of abuse, intensifying conflict, resulting in negative cycles of relating and poorer responsiveness to emotions when parenting. This study examined whether Tuning Relationships with Music, a dyadic therapy for parents and adolescents, increased responsive parent-adolescent interactions and parent emotion coaching whilst reducing conflict and adolescent mental health difficulties. Twenty-six parent-adolescent dyads were recruited if parents had a trauma history and the dyad were currently having high levels of conflict...
February 24, 2018: Child Abuse & Neglect
Khalid Tinasti
INTRODUCTION: The international community's commitment to halve by 2015 the HIV transmission among people who inject drugs has not only been largely missed, instead new HIV infections have increased by 30%. Moreover, drug injection remains one of the drivers of new HIV infections due to punitive responses and lack of harm reduction resourcing. In the midst of this situation, adolescents are a forgotten component of the global response to illegal drugs and their link with HIV infection...
February 2018: Journal of the International AIDS Society
Jörg Pont, Stefan Enggist, Heino Stöver, Brie Williams, Robert Greifinger, Hans Wolff
Clinical independence is an essential component of good health care and health care professionalism, particularly in correctional settings (jails, prisons, and other places of detention), where the relationship between patients and caregivers is not based on free choice and where the punitive correctional setting can challenge optimal medical care. Independence for the delivery of health care services is defined by international standards as a critical element for quality health care in correctional settings, yet many correctional facilities do not meet these standards because of a lack of awareness, persisting legal regulations, contradictory terms of employment for health professionals, or current health care governance structures...
February 22, 2018: American Journal of Public Health
Alexander S Tikhomirov, Chia-Yang Lin, Yulia L Volodina, Lyubov G Dezhenkova, Victor V Tatarskiy, Dominique Schols, Alexander A Shtil, Punit Kaur, Pin Ju Chueh, Andrey E Shchekotikhin
Chemical modifications of the anthraquinone scaffold are aimed at optimization of this exceptionally productive class of antitumor drugs. In particular, our previously reported anthra[2,3-b]furan-3-carboxamides demonstrated a high cytotoxic potency in cell culture and in vivo. In this study, we expanded our series of anthra[2,3-b]furan-3-carboxamides by modifying the key functional groups and dissected the structure-activity relationship within this chemotype. The majority of new compounds inhibited the growth of mammalian tumor cell lines at submicromolar to low micromolar concentrations...
February 10, 2018: European Journal of Medicinal Chemistry
Carmen Tereanu, Giuseppe Sampietro, Francesco Sarnataro, Dumitru Siscanu, Rodica Palaria, Victor Savin, Tatiana Cliscovscaia, Valentina Pislaru, Valeriu Oglinda, Larisa Capmare, Mugurel Stefan Ghelase, Tamara Turcanu
Background and aims: The Republic of Moldova is a small ex-soviet country in the Central Eastern European group of states, whose official language is Romanian. In countries with limited resources, quality improvement in healthcare and patient safety are very challenging. This study aims to identify which areas of the patient safety culture (PSC) need prompt intervention. Methods: A cross-sectional study was conducted in three Moldovan healthcare settings, using the Romanian translation of the US Hospital Survey on Patient Safety Culture HSOPSC...
2018: Clujul Medical (1957)
Jaeyeong Lee, Byung-Jung Park, Chungwon Lee
Current traffic law enforcement places an emphasis on reducing accident risk from human factors such as drunk driving and speeding. Among the various strategies implemented, demerit points and license sanction systems have been widely used as punitive and educational measures. Limitations, however, exist in previous studies in terms of estimating the interaction effects of demerit points and license sanctions. To overcome such limitations, this work focused on identifying the interaction effects of demerit points and license sanctions on driver traffic violation behavior...
February 14, 2018: Accident; Analysis and Prevention
Marjorie Montreuil, Catherine Thibeault, Linda McHarg, Franco A Carnevale
The experiences of children related to conflict and crisis management in child mental health settings, especially those aged 12 and below, have been rarely studied. This study examined the moral experiences of children related to conflict and crisis management and the related use of restraint and seclusion in a child mental health setting. A 5-month focused ethnography using a participatory hermeneutic framework was conducted in a day hospital programme for children with severe disruptive disorders within a mental health institute...
February 15, 2018: International Journal of Mental Health Nursing
Nicholas H Dodman, Dorothy C Brown, James A Serpell
Behavioral problems are a major source of poor welfare and premature mortality in companion dogs. Previous studies have demonstrated associations between owners' personality and psychological status and the prevalence and/or severity of their dogs' behavior problems. However, the mechanisms responsible for these associations are currently unknown. Other studies have detected links between the tendency of dogs to display behavior problems and their owners' use of aversive or confrontational training methods...
2018: PloS One
Punit Sharma
Sclerosing Angiomatoid Nodular Transformation (SANT) is a rare benign vascular tumor of spleen. It consists of multiple angiomatoid nodules surrounded by dense fibrous tissue that often coalesces centrally to form a scar, which is considered to be a characteristic feature. These are usually asymptomatic and incidentally detected on imaging for other underlying pathology. SANTs can be 18F-Fluorodeoxyglucose (18F-FDG) avid on positron emission tomography-computed tomography (PET-CT) and thus can lead to false positive finding in oncological patients...
2018: Nuclear Medicine Review. Central & Eastern Europe
Andrea L Wirtz, Tonia C Poteat, Mannat Malik, Nancy Glass
Gender-based violence (GBV) is an umbrella term for any harm that is perpetrated against a person's will and that results from power inequalities based on gender roles. Most global estimates of GBV implicitly refer only to the experiences of cisgender, heterosexually identified women, which often comes at the exclusion of transgender and gender nonconforming (trans) populations. Those who perpetrate violence against trans populations often target gender nonconformity, gender expression or identity, and perceived sexual orientation and thus these forms of violence should be considered within broader discussions of GBV...
January 1, 2018: Trauma, Violence & Abuse
Colton M Miller, W Brad Wan, Punit P Seth, Edward N Harris
Second-generation (Gen 2) Antisense oligonucleotides (ASOs) show increased nuclease stability and affinity for their RNA targets, which has translated to improved potency and therapeutic index in the clinic. Gen 2 ASOs are typically modified using the phosphorothioate (PS) backbone modification, which enhances ASO interactions with plasma, cell surface, and intracellular proteins. This facilitates ASO distribution to peripheral tissues and also promotes cellular uptake after injection into animals. Previous work identified that Stabilin receptors specifically internalize PS-ASOs in the sinusoidal endothelial cells of the liver and the spleen...
February 13, 2018: Nucleic Acid Therapeutics
Colton M Miller, Michael Tanowitz, Aaron J Donner, Thazha P Prakash, Eric E Swayze, Edward N Harris, Punit P Seth
Oligonucleotide therapeutics have emerged as a third distinct platform for drug discovery within the pharmaceutical industry. Five oligonucleotide-based drugs have been approved by the US FDA and over 100 oligonucleotides drugs are currently at different stages of human trials. Several of these oligonucleotide drugs are modified using the phosphorothioate (PS) backbone modification where one of the nonbridging oxygen atoms of the phosphodiester linkage is replaced with sulfur. In this review, we summarize our knowledge on receptor-mediated uptake of PS antisense oligonucleotides (ASOs) within different cell types of the liver-a privileged organ for the discovery of oligonucleotide-based therapeutics...
February 9, 2018: Nucleic Acid Therapeutics
Laura E Brumariu, Kathryn R Giuseppone, Kathryn A Kerns, Magali Van de Walle, Jean-François Bureau, Guy Bosmans, Karlen Lyons-Ruth
The purpose of this study was to assess behavioral manifestations of attachment in middle childhood, and to evaluate their relations with key theoretical correlates. The sample consisted of 87 children (aged 10-12 years) and their mothers. Dyads participated in an 8-min videotaped discussion of a conflict in their relationships, later scored with the Middle Childhood Attachment Strategies Coding System (MCAS) for key features of all child attachment patterns described in previous literature (secure, ambivalent, avoidant, disorganized-disoriented, caregiving/role-confused, hostile/punitive)...
February 5, 2018: Attachment & Human Development
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