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https://www.readbyqxmd.com/read/28528172/cannabis-and-pregnancy-maternal-child-health-implications-during-a-period-of-drug-policy-liberalization
#1
Katrina Mark, Mishka Terplan
Cannabis use is common and increasing among women in the United States. State policies are changing with a movement towards decriminalization and legalization. We explore the implications of cannabis liberalization for maternal and child health. Most women who use cannabis quit or cut back during pregnancy. Although women are concerned about the possible health effects of cannabis, providers do a poor job of counseling. There is a theoretical potential for cannabis to interfere with neurodevelopment, however human data have not identified any long-term or long lasting meaningful differences between children exposed in utero to cannabis and those not...
May 17, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28525457/stensen-duct-relapse-of-diffuse-large-b-cell-lymphoma-an-unusual-pattern-detected-with-18f-fdg-pet-ct
#2
Punit Sharma, Shilpa Bhartia
F-FDG PET/CT is now an established modality for staging and restaging high-grade lymphomas, including diffuse large B-cell lymphoma. We here present the case of a 51-year-old woman successfully treated for diffuse large B-cell lymphoma. Follow-up F-FDG PET/CT demonstrated an unusual site of relapse involving left Stensen (parotid) duct, which was confirmed with cytology. By identifying such unusual sites of lymphomatous involvement, F-FDG PET/CT can have significant bearing on patient management.
May 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28516855/victim-impact-statements-how-victim-social-class-affects-juror-decision-making
#3
Kimberly Schweitzer, Narina Nuñez
Although the Supreme Court has ruled that victim impact statements (VIS) should be allowed at trial, the concern voicedin Payne v. Tennessee (1991) and Furman v. Georgia (1972) was that VIS might enable jurors to make comparative judgments about the worth of the victim. This study examined the effect VIS and low and middle socioeconomic status (SES) victims have on jurors' decisions. Mock jurors listened to 1 of 3 audio recordings of the sentencing phase of a capital murder trial (no VIS, low SES VIS, or middle SES VIS) and were asked to sentence the defendant to either life in prison without parole or death...
May 17, 2017: Violence and Victims
https://www.readbyqxmd.com/read/28515998/dermoscopy-of-histoid-leprosy-a-case-report
#4
Balachandra S Ankad, Punit S Sakhare
No abstract text is available yet for this article.
April 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28513322/people-with-and-without-prosopagnosia-have-insight-into-their-face-recognition-ability
#5
Lucy Anne Livingston, Punit Shah
No abstract text is available yet for this article.
May 17, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28499947/effect-of-chemical-denaturants-on-the-conformational-stability-of-gyrb-subunit-of-dna-gyrase-from-salmonella-enterica-serovar-typhi
#6
Deepali Gupta, Ekta Sachdeva, Md Anzarul Haque, Safikur Rahman, Rohit Bansal, Abdul S Ethayathulla, Md Imtaiyaz Hassan, Punit Kaur
DNA gyrase, a type II topoisomerase maintains the topology of DNA by introducing negative supercoils using energy generated by ATP hydrolysis. It is composed of two subunits, GyrA and GyrB (GyrA2GyrB2 hetero-tetramer). GyrB comprises two domains, a 43kDa amino N-terminus (GBNTD) and 47kDa carboxyl C- terminus (GBCTD). Till now no study has been reported in terms of stability of Gyrase B and its domains using chemical denaturants related to its function. To understand the role of each domain in GyrB subunit, we estimated the thermodynamic stability of GBF and its individual domains using urea and GdmCl...
May 9, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28491011/an-integrated-proteomic-and-glycoproteomic-approach-uncovers-differences-in-glycosylation-occupancy-from-benign-and-malignant-epithelial-ovarian-tumors
#7
Qing Kay Li, Punit Shah, Yuan Tian, Yingwei Hu, Richard B S Roden, Hui Zhang, Daniel W Chan
BACKGROUND: Epithelial ovarian carcinomas encompass a heterogeneous group of diseases with a poor 5-year survival rate. Serous carcinoma is the most common type. Most FDA-approved serum tumor markers are glycoproteins. These glycoproteins on cell surface or shed into the bloodstream could serve as therapeutic targets as well as surrogates of tumor. In addition to glycoprotein expressions, the analysis of protein glycosylation occupancy could be important for the understanding of cancer biology as well as the identification of potential glycoprotein changes in cancer...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28472515/identification-of-metabolically-stable-5%C3%AE-phosphate-analogs-that-support-single-stranded-sirna-activity
#8
Thazha P Prakash, Walt F Lima, Heather M Murray, Wenyu Li, Garth A Kinberger, Alfred E Chappell, Hans Gaus, Punit P Seth, Balkrishen Bhat, Stanley T Crooke, Eric E Swayze
No abstract text is available yet for this article.
May 1, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28469522/unmasking-the-role-of-uptake-transporters-for-digoxin-uptake-across-the-barriers-of-the-central-nervous-system-in-rat
#9
Kunal S Taskar, T Thanga Mariappan, Vishwanath Kurawattimath, Shashyendra Singh Gautam, T V Radhakrishna Mullapudi, Srikanth K Sridhar, Raja Reddy Kallem, Punit Marathe, Sandhya Mandlekar
The role of uptake transporter (organic anion-transporting polypeptide [Oatp]) in the disposition of a P-glycoprotein (P-gp) substrate (digoxin) at the barriers of central nervous system, namely, the blood-brain barrier (BBB), blood-spinal cord barrier (BSCB), and brain-cerebrospinal fluid barrier (BCSFB), was studied using rat as a preclinical species. In vivo chemical inhibition of P-gp and Oatp was achieved using elacridar and rifampicin, respectively. Our findings show that (1) digoxin had a low brain-to-plasma concentration ratio (B/P) (0...
2017: Journal of Central Nervous System Disease
https://www.readbyqxmd.com/read/28461442/the-austere-life
#10
Nicholas Xenos
Since the 2008 financial crisis, austerity has been deployed as a public policy geared towards reducing sovereign debt and restoring economic order, on the one hand, and descried as an example of punitive moralizing by political and economic elites, on the other. This article challenges the economic understanding of the concept of austerity. Some recent examples from popular culture are adduced to indicate societal dissatisfaction with the accumulation of material things, examples of what has been called 'the new minimalism'...
June 13, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28450081/a-qualitative-study-of-what-u-s-parents-say-and-do-when-their-young-children-see-pornography
#11
Emily F Rothman, Jennifer Paruk, Ashlee Espensen, Jeff R Temple, Kelley Adams
OBJECTIVE: There is no empirical information about how parents react when they discover that their young children have seen pornography. To address this gap in the literature, the current study sought to improve our understanding of parental reactions to discovering that their children ages <12 years old have seen pornography using a mixed-methods approach. METHODS: A convenience sample of participants (N=279) were recruited from the online survey service mTurk...
April 24, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/28448194/co-administration-of-an-excipient-oligonucleotide-helps-delineate-pathways-of-productive-and-nonproductive-uptake-of-phosphorothioate-antisense-oligonucleotides-in-the-liver
#12
Aaron J Donner, Edward V Wancewicz, Heather M Murray, Sarah Greenlee, Noah Post, Melanie Bell, Walt F Lima, Eric E Swayze, Punit P Seth
Phosphorothioate (PS) modified antisense oligonucleotides (ASOs) have progressed rapidly in the clinic for treating a variety of disease indications. We previously demonstrated that the activity of PS ASOs in the liver can be enhanced by co-infusion of an excipient oligonucleotide (EON). It was posited that the EON saturates a nonproductive uptake pathway(s) thereby permitting accumulation of the PS ASO in a productive tissue compartment. In this report, we measured PS ASO activity following administration by bolus, infusion or co-fusion with EON within hepatocytes and nonparenchymal cells (NPCs), of the liver...
April 27, 2017: Nucleic Acid Therapeutics
https://www.readbyqxmd.com/read/28442980/safety-issues-of-endobronchial-intubation-for-one-lung-ventilation-in-video-assisted-thoracoscopic-surgery-in-neonates-can-we-extubate-on-the-table
#13
Lokesh Kashyap, Neisevilie Nisa, Apala Roy Chowdhury, Punit Khanna
No abstract text is available yet for this article.
April 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28442880/trichoscopic-patterns-in-squamous-cell-carcinoma-a-case-report
#14
Balachandra S Ankad, Mahajabeen Madarkar, Gourishetty Saipriya, Punit S Sakhare, Vijay D Dombale
Squamous cell carcinoma (SCC) is the second most cutaneous malignancy after basal cell carcinoma (BCC) with increasing incidence. In the view its nodular manifestation; it can appear similar to nodular BCC, atypical fibroxanthoma, sclerosing liposarcoma and desmoplastic melanoma. Prognostic and therapeutic implications are different in all these conditions and thus their distinction becomes important. Trichoscopy is a simple and non-invasive technique to visualize certain morphological features of skin lesions and it improves the diagnostic accuracy for melanocytic and nonmelanocytic pigmented lesions...
October 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/28436240/biotherapeutic-potential-and-mechanisms-of-action-of-colchicine
#15
Kashyap Kumar Dubey, Punit Kumar, Nikolaos E Labrou, Pratyoosh Shukla
Cancer is a clinical situation caused by uncontrolled cell division and is responsible for a large number of deaths worldwide. Colchicine is a classical antimitotic, tubulin-binding agent (TBA) which is being explored for its antitumor activities, although its tubulin-binding ability leads to some toxicity toward normal cells proliferation. Colchicine derivatives are considered as potent antitumor compounds with less toxicity compared to colchicine. Derivatives with substituted functional groups at A-ring (methoxy), B-ring (acetamide) or C-ring (methoxy) have been synthesized via chemical and microbial routes and show modified bioactivities and altered tropolonic functionality...
April 23, 2017: Critical Reviews in Biotechnology
https://www.readbyqxmd.com/read/28416021/effects-of-gabab-receptors-in-the-insula-on-recognition-memory-observed-with-intellicage
#16
Nan Wu, Feng Wang, Zhe Jin, Zhen Zhang, Lian-Kun Wang, Chun Zhang, Tao Sun
BACKGROUND: Insular function has gradually become a topic of intense study in cognitive research. Recognition memory is a commonly studied type of memory in memory research. GABABR has been shown to be closely related to memory formation. In the present study, we used intellicage, which is a new intelligent behavioural test system, and a bilateral drug microinjection technique to inject into the bilateral insula, to examine the relationship between GABABR and recognition memory. METHODS: Male Sprague-Dawley rats were randomly divided into control, Sham, Nacl, baclofen and CGP35348 groups...
April 17, 2017: Behavioral and Brain Functions: BBF
https://www.readbyqxmd.com/read/28403278/patient-safety-characterization-of-youtube-videos
#17
Pétala Tuani Candido de Oliveira Salvador, Theo Duarte da Costa, Andréa Tayse de Lima Gomes, Yole Matias Silveira de Assis, Viviane Euzébia Pereira Santos
Objective: To describe how patient safety is addressed in YouTube videos. Methods: descriptive study with a quantitative approach. Data was collected in May 2015, at YouTube's search field, with descriptor "patient safety". The sample included 92 videos, which were analyzed using descriptive statistics. Results: The videos showed a positive concept of patient safety, based on a systemic vision that attempts to eliminate the traditional punitive culture by promoting a culture of safety...
April 10, 2017: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/28401833/atypical-dimensions-of-caregiver-adolescent-interaction-in-an-economically-disadvantaged-sample
#18
Roger Kobak, Kristyn Zajac, Caroline Abbott, Abby Zisk, Nadia Bounoua
The Goal-Corrected Partnership Adolescent Coding System (GPACS) has shown promise in assessing a secure as well as three atypical patterns of parent-adolescent interaction during a conflict discussion. The current study of 186 economically disadvantaged families examines the degree to which four GPACS patterns: secure/collaborative, hostile/punitive, role confused, and disoriented, prospectively predict adolescents' social competence and maladaptive behavior (internalizing, externalizing, and risk behaviors) at age 15 years after controlling for these social behaviors at age 13 years and contemporaneous GPACS scores...
May 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28401507/improving-student-engagement-in-the-study-of-professional-ethics-concepts-and-an-example-in-cyber-security
#19
John D Bustard
In spite of the acknowledged importance of professional ethics, technical students often show little enthusiasm for studying the subject. This paper considers how such engagement might be improved. Four guiding principles for promoting engagement are identified: (1) aligning teaching content with student interests; (2) taking a pragmatic rather than a philosophical approach to issue resolution; (3) addressing the full complexity of real-world case studies; and (4) covering content in a way that students find entertaining...
April 11, 2017: Science and Engineering Ethics
https://www.readbyqxmd.com/read/28401274/posttraumatic-stress-disorder-trauma-and-reconciliation-in-south-sudan
#20
Lauren C Ng, Belkys López, Matthew Pritchard, David Deng
PURPOSE: South Sudan is embroiled in a conflict that erupted in December 2013. This study examines what people in South Sudan think is necessary to achieve reconciliation and how trauma exposure and PTSD are associated with those beliefs. METHODS: 1525 participants (51.0% female) were selected using random and purposive sampling in six states and Abyei. Participants reported on traumatic events, PTSD symptoms, and attitudes towards reconciliation mechanisms. RESULTS: Results indicated that 40...
April 11, 2017: Social Psychiatry and Psychiatric Epidemiology
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