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https://www.readbyqxmd.com/read/28810157/propagating-the-haze-community-and-professional-perceptions-of-cannabis-cultivation-and-the-impacts-of-prohibition
#1
Helen Beckett Wilson, Stuart Taylor, Giles Barrett, Janet Jamieson, Lauren Grindrod
BACKGROUND: Recent decades have seen substantial changes in the UK cannabis landscape, including increased domestic production, the ascendancy of stronger strains (namely 'skunk') and the drug's reclassification under the 1971 Misuse of Drugs Act. Resultantly, cannabis retains significance in the consciousness, priorities and policy agendas of communities, drug services and criminal justice agencies. METHODS: This paper presents an empirical study, which examined both perceptions and impacts of cannabis cultivation and its control within a North-West English borough...
August 12, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28801944/the-emergence-of-second-generation-lethal-injection-protocols-a-brief-history-and-review
#2
Daniel R Malcom, Frank Romanelli
The history of capital punishment in the United States is long and controversial. In many cases, lethal injection has brought medical personnel, ethically and professionally charged with preserving life, into the arena of assisting the state in taking life. Recent US Supreme Court decisions, including Baze v. Rees and Glossip v. Gross, have evaluated and condoned lethal injection protocols. Despite the judicial validation of some midazolam-containing protocols, controversy exists as to the level of unconsciousness provided due to the ceiling effects of the drug...
August 12, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28801812/a%C3%A2-synopsis-of-the-history-of-hansen-s-disease
#3
Raissa Gonçalves Couto Dal Secco, Katlein França, David Castillo, Mana AlHarbi, Torello Lotti, Massimo Fioranelli, Maria Grazia Roccia
Leprosy is a contagious infectious disease caused by the bacillus Mycobacterium leprae. This microorganism was discovered by Dr. Gerhard Hansen, and the illness was then baptized as Hansen's disease. For a long time, Hansen's disease was thought to be hereditary-a curse or a punishment from God. The disease affects skin and nerves and can cause severe damage. Due to its destructive effects, leprosy has caused fear, segregation, and prejudice in all societies since Biblical times. Patients with Hansen's disease have not been treated humanely around the world throughout the ages...
August 11, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28801443/the-provision-of-medical-assistance-in-dying-protocol-for-a-scoping-review
#4
Simon J W Oczkowski, Ian Ball, Carol Saleh, Gaelen Kalles, Anatoli Chkaroubo, Mike Kekewich, Paul Miller, Marianne Dees, Andrea Frolic
INTRODUCTION: Medical assistance in dying (MAID), a term encompassing both euthanasia and assisted suicide, was decriminalised in Canada in 2015. Although Bill C-14 legislated eligibility criteria under which patients could receive MAID, it did not provide guidance regarding the technical aspects of providing an assisted death. Therefore, we propose a scoping review to map the characteristics of the existing medical literature describing the medications, settings, participants and outcomes of MAID, in order to identify knowledge gaps and areas for future research...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28792360/in-their-own-words-a-qualitative-exploration-of-last-statements-of-capital-punishment-inmates-in-the-state-of-missouri-1995-2011
#5
Maranda A Upton, Tabitha M Carwile, Kristina S Brown
Last statements have been a common practice as part of capital punishment as far back as the 1300s in Europe. In the United States, the first execution occurred in 1608, and currently, 32 states have the death penalty. In 1991, Missouri integrated death row inmates into the general prison population, which makes this population unique compared with other death row populations across the United States. This article is a qualitative study on the themes found in the last statements of 46 capitally punished inmates in Missouri from 1995 to 2011...
September 2017: Omega
https://www.readbyqxmd.com/read/28791332/deep-brain-stimulation-of-the-subthalamic-nucleus-selectively-decreases-risky-choice-in-risk-preferring-rats
#6
Wendy K Adams, Cole Vonder Haar, Melanie Tremblay, Paul J Cocker, Mason M Silveira, Sukhbir Kaur, Christelle Baunez, Catharine A Winstanley
Deep brain stimulation of the subthalamic nucleus (STN-DBS) can improve the motor symptoms of Parkinson's disease (PD) and negate the problematic side effects of dopamine replacement therapy. Although there is concern that STN-DBS may enhance the development of gambling disorder and other impulse control disorders in this patient group, recent data suggest that STN-DBS may actually reduce iatrogenic impulse control disorders, and alleviate obsessive-compulsive disorder (OCD). Here, we sought to determine whether STN-DBS was beneficial or detrimental to performance of the rat gambling task (rGT), a rodent analogue of the Iowa Gambling Task (IGT) used to assess risky decision making clinically...
July 2017: ENeuro
https://www.readbyqxmd.com/read/28777999/perceptions-of-plagiarisers-the-influence-of-target-physical-attractiveness-transgression-severity-and-sex-on-attributions-of-guilt-and-punishment
#7
Viren Swami, Elizabeth Arthey, Adrian Furnham
The attractiveness-leniency effect (ALE) suggests that physically attractive targets are less likely to be perceived as guilty compared to less attractive targets. Here, we tested the ALE in relation to attributions of students who have committed plagiarism. British adults (N=165) were shown one of eight vignette-photograph pairings varying in target sex (female/male), physical attractiveness (high/low), and transgression severity (serious/minor), and provided attributions of guilt and severity of punishment...
August 1, 2017: Body Image
https://www.readbyqxmd.com/read/28775326/retrograde-bdnf-to-trkb-signaling-promotes-synapse-elimination-in-the-developing-cerebellum
#8
Myeongjeong Choo, Taisuke Miyazaki, Maya Yamazaki, Meiko Kawamura, Takanobu Nakazawa, Jianling Zhang, Asami Tanimura, Naofumi Uesaka, Masahiko Watanabe, Kenji Sakimura, Masanobu Kano
Elimination of early-formed redundant synapses during postnatal development is essential for functional neural circuit formation. Purkinje cells (PCs) in the neonatal cerebellum are innervated by multiple climbing fibers (CFs). A single CF is strengthened whereas the other CFs are eliminated in each PC dependent on postsynaptic activity in PC, but the underlying mechanisms are largely unknown. Here, we report that brain-derived neurotrophic factor (BDNF) from PC facilitates CF synapse elimination. By PC-specific deletion of BDNF combined with knockdown of BDNF receptors in CF, we show that BDNF acts retrogradely on TrkB in CFs, and facilitates elimination of CF synapses from PC somata during the third postnatal week...
August 4, 2017: Nature Communications
https://www.readbyqxmd.com/read/28772109/differentiation-of-cannabis-subspecies-by-thca-synthase-gene-analysis-using-rflp
#9
Natasa Cirovic, Miljana Kecmanovic, Dusan Keckarevic, Milica Keckarevic Markovic
Cannabis sativa subspecies, known as industrial hemp (C. sativa sativa) and marijuana (C. sativa indica) show no evident morphological distinctions, but they contain different levels of psychoactive Δ-9-tetrahidrocanabinol (THC), with considerably higher concentration in marijuana than in hemp. C. sativa subspecies differ in sequence of tetrahydrocannabinolic acid (THCA) synthase gene, responsible for THC production, and only one active copy of the gene, distinctive for marijuana, is capable of producing THC in concentration more then 0,3% in dried plants, usually punishable by the law...
July 25, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28769066/long-term-memory-requires-sequential-protein-synthesis-in-three-subsets-of-mushroom-body-output-neurons-in-drosophila
#10
Jie-Kai Wu, Chu-Yi Tai, Kuan-Lin Feng, Shiu-Ling Chen, Chun-Chao Chen, Ann-Shyn Chiang
Creating long-term memory (LTM) requires new protein synthesis to stabilize learning-induced synaptic changes in the brain. In the fruit fly, Drosophila melanogaster, aversive olfactory learning forms several phases of labile memory to associate an odor with coincident punishment in the mushroom body (MB). It remains unclear how the brain consolidates early labile memory into LTM. Here, we survey 183 Gal4 lines containing almost all 21 distinct types of MB output neurons (MBONs) and show that sequential synthesis of learning-induced proteins occurs at three types of MBONs...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28763786/child-maltreatment-in-nepal-prevalence-and-associated-factors
#11
P Kandel, R Kunwar, S Karki, D Kandel, P Lamichhane
OBJECTIVES: Child maltreatment is a global public health problem. There is limited information about this problem in low-income countries. We aimed to document the prevalence and factors associated with physical punishment of children less than 14 years of age in Nepal. STUDY DESIGN: Population-based cross-sectional study. METHODS: We conducted an in-depth analysis using data from the Nepal Multiple Indicator Cluster Survey, a nationally representative multi-stage-stratified cluster sampling survey...
July 29, 2017: Public Health
https://www.readbyqxmd.com/read/28762534/perceptions-of-voluntary-consent-among-jail-diverted-veterans-with-co-occurring-disorders
#12
Max L Trojano, Paul P Christopher, Debra A Pinals, Autumn Harnish, David Smelson
This study assessed perceptions of voluntary consent among 69 veterans who enrolled in a "jail diversion" program for co-occurring disorders. Perceptions were measured using modified items from the MacArthur Perceived Coercion and Negative Pressure Scales. A majority reported that they "chose to" (88.4%) or "felt free to" (85.5%) enroll. Most reported having "control over" (69.6%) and "more influence than anyone else" regarding (60.9%) their participation. About half reported that enrollment was "their idea" (49...
August 1, 2017: Behavioral Sciences & the Law
https://www.readbyqxmd.com/read/28761063/elevated-levels-of-the-stress-hormone-corticosterone-cause-pessimistic-judgment-bias-in-broiler-chickens
#13
Oluwaseun S Iyasere, Andrew P Beard, Jonathan H Guy, Melissa Bateson
Pessimistic judgment biases, whereby humans or non-human animals interpret ambiguous information negatively, are hypothesised to be one of the suite of adaptive changes that comprise the vertebrate stress response. To test this hypothesis, we asked whether experimentally elevating levels of the glucocorticoid stress hormone, corticosterone, in broiler chickens produced a pessimistic judgment bias. We trained young chickens to discriminate a stimulus (paper cone) placed at two locations in an arena, one associated with reward (mealworms) and one with punishment (air puff)...
July 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28758882/attitude-towards-gender-roles-and-violence-against-women-and-girls-vawg-baseline-findings-from-an-rct-of-1752-youths-in-pakistan
#14
Tazeen Saeed Ali, Rozina Karmaliani, Judith Mcfarlane, Hussain M A Khuwaja, Yasmeen Somani, Esnat D Chirwa, Rachel Jewkes
BACKGROUND: Violence against women is driven by gender norms that normalize and justify gender inequality and violence. Gender norms are substantially shaped during adolescence. Programs offered through schools offer an opportunity to influence gender attitudes toward gender equity if we understand these to be partly shaped by peers and the school environment. OBJECTIVE: We present an analysis of the baseline research conducted for a randomized controlled trial with 1752 grade 6 boys and girls and their attitudes toward gender roles, VAWG, and associated factors...
2017: Global Health Action
https://www.readbyqxmd.com/read/28758780/the-development-of-intention-based-morality-the-influence-of-intention-salience-and-recency-negligence-and-outcome-on-children-s-and-adults-judgments
#15
Gavin Nobes, Georgia Panagiotaki, Paul E Engelhardt
Two experiments were conducted to investigate the influences on 4-8 year-olds' and adults' moral judgments. In both, participants were told stories from previous studies that had indicated that children's judgments are largely outcome-based. Building on recent research in which one change to these studies' methods resulted in substantially more intention-based judgment, in Experiment 1 (N = 75) the salience and recency of intention information were increased, and in Experiment 2 (N = 99) carefulness information (i...
July 31, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28754407/punishment-of-alcohol-reinforced-responding-in-alcohol-preferring-p-rats-reveals-a-bimodal-population-implications-for-models-of-compulsive-drug-seeking
#16
Nathan J Marchant, Erin J Campbell, Konstantin Kaganovsky
Individual variations in animal behaviour can be used to describe relationships between different constructs, as well as the underlying neurobiological mechanisms responsible for such variation. In humans, variation in the expression of certain traits contributes to the onset of psychopathologies, such as drug addiction. Addiction is characterised by persistent drug use despite negative consequences, but it occurs in only a sub-population of drug users. Compulsive drug use is modelled in laboratory animals by punishing a drug-reinforced operant response...
July 25, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28753081/-even-though-a-man-takes-the-major-role-he-has-no-right-to-abuse-future-male-leaders-views-on-gender-based-violence-in-sri-lanka
#17
Elisabeth Darj, Kumudu Wijewardena, Gunilla Lindmark, Pia Axemo
BACKGROUND: Distinct gender roles influence gender inequality and build the foundation for gender-based violence. Violence against women is a major public health problem in all societies, and a violation of human rights. Prevalence surveys on gender-based violence have been published from Sri Lanka, but qualitative studies on men's perceptions are lacking. OBJECTIVES: The aim of this study was to explore young educated Sri Lankan men's perceptions of violence against women...
2017: Global Health Action
https://www.readbyqxmd.com/read/28752329/reward-and-punishment-based-compound-cue-learning-and-generalization-in-opiate-dependency
#18
Justin Mahlberg, Paul Haber, Kirsten Morley, Gabrielle Weidemann, Lee Hogarth, Kevin D Beck, Catherine E Myers, Ahmed A Moustafa
Substance dependence is thought to be mediated by abnormalities in cognitive abilities, but how this impacts decision-making remains unclear. This study aimed to test whether people who are opiate dependent differed from never-dependent controls in learning from reward and punishment or in the generalization of learning to novel conditions. Participants with opiate dependency consisted of 21 people who were outpatients in a methadone maintenance program; the control group consisted of 21 healthy participants with no histories of substance abuse...
July 27, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28752111/olfactory-cued-learning-paradigm
#19
Gary Liu, Cynthia K McClard, Burak Tepe, Jessica Swanson, Brandon Pekarek, Sugi Panneerselvam, Benjamin R Arenkiel
Sensory stimulation leads to structural changes within the CNS (Central Nervous System), thus providing the fundamental mechanism for learning and memory. The olfactory circuit offers a unique model for studying experience-dependent plasticity, partly due to a continuous supply of integrating adult born neurons. Our lab has recently implemented an olfactory cued learning paradigm in which specific odor pairs are coupled to either a reward or punishment to study downstream circuit changes. The following protocol outlines the basic set up for our learning paradigm...
May 5, 2017: Bio-protocol
https://www.readbyqxmd.com/read/28747623/anterior-cingulate-is-a-source-of-valence-specific-information-about-value-and-uncertainty
#20
Ilya E Monosov
Anterior cingulate cortex (ACC) is thought to control a wide range of reward, punishment, and uncertainty-related behaviors. However, how it does so is unclear. Here, in a Pavlovian procedure in which monkeys displayed a diverse repertoire of reward-related, punishment-related, and uncertainty-related behaviors, we show that many ACC-neurons represent expected value and uncertainty in a valence-specific manner, signaling value or uncertainty predictions about either rewards or punishments. Other ACC-neurons signal prediction information about rewards and punishments by displaying excitation to both (rather than excitation to one and inhibition to the other)...
July 26, 2017: Nature Communications
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