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https://www.readbyqxmd.com/read/28108108/pharmaceuticals-and-personal-care-products-in-plants
#1
REVIEW
Mireia Bartrons, Josep Peñuelas
Pharmaceuticals and personal-care products (PPCPs) derived from agricultural, urban, and industrial areas accumulate in plants at concentrations (ng to μg kg(-1)) that can be toxic to the plants. Importantly, the dietary intake of these PPCP-contaminated plants may also pose a risk to human health, but currently little is known about the fate of PPCPs in plants and their effect on or risk to the ecosystem. In this Opinion article we propose that in-depth research on the use of plants as a monitoring device for assessing the use and environmental presence of PPCPs is warranted...
January 17, 2017: Trends in Plant Science
https://www.readbyqxmd.com/read/28105594/screening-of-inorganic-and-organic-contaminants-in-floodwater-in-paddy-fields-of-hue-and-thanh-hoa-in-vietnam
#2
Ha Thu Trinh, Helle Marcussen, Hans Christian B Hansen, Giang Truong Le, Hanh Thi Duong, Nguyen Thuy Ta, Trung Quang Nguyen, Soren Hansen, Bjarne W Strobel
In the rainy season, rice growing areas in Vietnam often become flooded by up to 1.5 m water. The floodwater brings contaminants from cultivated areas, farms and villages to the rice fields resulting in widespread contamination. In 2012 and 2013, the inorganic and organic contaminants in floodwater was investigated in Thanh Hoa and Hue. Water samples were taken at 16 locations in canals, paddy fields and rivers before and during the flood. In total, 940 organic micro-pollutants in the water samples were determined simultaneously by GC-MS method with automatic identification and quantification system (AIQS), while ICP-MS was used for determination of ten trace elements in the samples...
January 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28105593/monitoring-pharmaceuticals-and-personal-care-products-in-reservoir-water-used-for-drinking-water-supply
#3
Carolina Aristizabal-Ciro, Ana María Botero-Coy, Francisco J López, Gustavo A Peñuela
In this work, the presence of selected emerging contaminants has been investigated in two reservoirs, La Fe (LF) and Rio Grande (RG), which supply water to two drinking water treatment plants (DWTPs) of Medellin, one of the most populated cities of Colombia. An analytical method based on solid-phase extraction (SPE) of the sample followed by measurement by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) was developed and validated for this purpose. Five monitoring campaigns were performed in each reservoir, collecting samples from 7 sites (LF) and 10 sites (RG) at 3 different depths of the water column...
January 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28104333/response-of-lemna-gibba-l-to-high-and-environmentally-relevant-concentrations-of-ibuprofen-removal-metabolism-and-morpho-physiological-traits-for-biomonitoring-of-emerging-contaminants
#4
D Di Baccio, F Pietrini, P Bertolotto, S Pérez, D Barcelò, M Zacchini, E Donati
The increasing worldwide consumption of pharmaceuticals and personal care products such as ibuprofen (IBU) is leading to the widespread and persistent occurrence of these chemicals and their transformation products in soils and waters. Although at low concentrations, the continuous discharge of these micropollutants and the incomplete removal by the actual wastewater treatments can provoke accumulation in the environment with risks for the trophic chain. Non-target organisms as duckweed can be used for the environmental monitoring of pharmaceutical emerging contaminants...
January 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28099661/pharmaceutical-lobbying-in-brazil-a-missing-topic-in-the-public-health-research-agenda
#5
Francisco José Roma Paumgartten
In the US, where registration of lobbyists is mandatory, the pharmaceutical industry and private health-care providers spend huge amounts of money seeking to influence health policies and government decisions. In Brazil, where lobbying lacks transparency, there is virtually no data on drug industry expenditure to persuade legislators and government officials of their viewpoints and to influence decision-making according to commercial interests. Since 1990, however, the Associação da Indústria Farmacêutica de Pesquisa (Interfarma - Pharmaceutical Research Industry Association), Brazilian counterpart of the Pharmaceutical Research and Manufacturers of America (PhRMA), main lobbying organization of the US pharmaceutical industry, has played a major role in the advocacy of interests of major drug companies...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28098924/-hypernatremia-caused-by-treatment-with-ghb-obtained-via-a-doctor-s-prescription
#6
I M Rood, C G W Seijger, J A van Waarde, M M R de Maat, J C Verhave, M J Blans
In the last few years, gamma hydroxybutyric acid (GHB) has been used increasingly as a party drug; this has led to a marked increase in the number of requests for professional help with the treatment of GHB addiction. Pharmaceutical GHB (sodium oxybate, the sodium-salt of GHB), registered for cataplexia in narcolepsy patients, is used off-label to treat the withdrawal symptoms associated with GHB addiction. Pharmaceutical GHB has a high sodium load. In this report we present the cases of two patients who developed symptomatic hypernatremia following treatment with pharmaceutical GHB and who thereafter needed intensive care for the severe withdrawal symptoms that they experienced...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28098264/assessment-of-coulometric-array-electrochemical-detection-coupled-with-hplc-uv-for-the-absolute-quantitation-of-pharmaceuticals
#7
Michael B Hicks, Leah Salituro, Ian Mangion, Wes Schafer, Rong Xiang, Xiaoyi Gong, Christopher J Welch
The use of a coulometric array detector in tandem with HPLC-UV was evaluated for the absolute quantitation of pharmaceutical compounds without standards, an important capability gap in contemporary pharmaceutical research and development. The high-efficiency LC flow-through electrochemical detector system allows for the rapid evaluation of up to 16 different potentials, aiding in the identification and quantitation of electrochemically reactive species. By quantifying the number of electrons added or removed from an analyte during its passage through the detector, the number of moles of the analyte can be established...
January 18, 2017: Analyst
https://www.readbyqxmd.com/read/28097722/antimicrobial-utilization-in-an-iraqi-province-a-comprehensive-evaluation-of-antibiotic-source-and-cost
#8
Ali A Al-Jumaili, Ahmed H Hussein, Mohammed D Al-Rekabi, Saba A Raheem, Erika J Ernst
PURPOSE: The aims were to calculate total systemic antibiotic consumption and cost in both public and private sectors in all care settings in Al-Najaf province, Iraq, during 2012, recognize the percentage of each pharmacological class for the dispensed antibiotics and identify oral and parenteral antibiotic percentages dispensed and the portions manufactured nationally and imported. METHODS: Cross-sectional study was conducted in Al-Najaf to calculate the total cost and quantities of antibiotics consumed during 2012 using World Health Organization Guidelines for Defined Daily Dose (DDD)...
February 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28095545/real-time-high-resolution-in-vivo-characterization-of-superficial-skin-with-microscopy-using-ultraviolet-surface-excitation-muse
#9
Derek Ho, Farzad Fereidouni, Richard M Levenson, Jared Jagdeo
BACKGROUND: Skin care products make up the largest part (36%) of the cosmetic market globally, of which the United States plays the largest role. In 2015, approximately 115 billion USD was spent globally on skin care products. Skin care products, in contradistinction to pharmaceuticals, are not strictly regulated by the FDA. A key factor for evaluation of a skin care product or topical drug is skin barrier function and effect on super cial skin. Thus, it is critical to have quantitative and qualitative methods to study the effects of skin care products on skin barrier and the super cial skin...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28093993/methods-of-screening-purification-and-antimicrobial-potentialities-of-bacteriocin-in-health-care
#10
Varish Ahmad, Qazi Mohammad Sajid Jamal, Mughees Uddin Siddiqui, Arun K Shukla, Mohammad A Alzohairy, Mohammad A Al Karaawi, Mohammad Amjad Kamal
The Antibiotics of twentieth century have emerged to decrease the mortality and morbidity among the human population, but these are costly and toxic to beneficial intestinal micro flora. The safe and convenient proteinacious antimicrobial molecule, active at nanomolar concentration and synthesized by ribosomes, is bacteriocin. It has been tested not only to inhibit a wide range of microbial pathogens, but also to treat and diagnose the cancer. Its use as bio-controlling agent in agriculture also accelerated the research of bacteriocin...
January 16, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28090098/evaluation-of-a-teaching-assistant-program-for-third-year-pharmacy-students
#11
Courtney L Bradley, Julia Khanova, Kelly L Scolaro
Objectives. To determine if a teaching assistant (TA) program for third-year pharmacy students (PY3s) improves confidence in teaching abilities. Additionally, 3 assessment methods (faculty, student, and TA self-evaluations) were compared for similarities and correlations. Methods. An application and interview process was used to select 21 pharmacy students to serve as TAs for the Pharmaceutical Care Laboratory course for 2 semesters. Participants' self-perceived confidence in teaching abilities was assessed at the start, midpoint, and conclusion of the program...
November 25, 2016: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/28089530/algae-mediated-removal-of-selected-pharmaceutical-and-personal-care-products-ppcps-from-lake-mead-water
#12
Xuelian Bai, Kumud Acharya
The persistence and fate of pharmaceutical and personal care products (PPCPs) in the Lake Mead ecosystem are particularly important considering the potential ecological risks and human health impacts. This study evaluated the removal of five common PPCPs (i.e., trimethoprim, sulfamethoxazole, carbamazepine, ciprofloxacin, and triclosan) from Lake Mead water mediated by the green alga Nannochloris sp. The results from the incubation studies showed that trimethoprim and carbamazepine were highly resistant to uptake in the algal cultural medium and were measured at approximately 90%-100% of the applied dose after 14days of incubation...
January 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28086784/health-related-quality-of-life-assessment-in-acute-coronary-syndrome-patients-the-effectiveness-of-early-phase-i-cardiac-rehabilitation
#13
Lawrence Anchah, Mohamed Azmi Hassali, Melissa Siaw Han Lim, Mohamed Izham Mohamed Ibrahim, Kui Hian Sim, Tiong Kiam Ong
BACKGROUND: Acute Coronary Syndrome (ACS) is one of the most burdensome cardiovascular diseases in terms of the cost of interventions. The Cardiac Rehabilitation Programme (CRP) is well-established in improving clinical outcomes but the assessment of actual clinical improvement is challenging, especially when considering pharmaceutical care (PC) values in phase I CRP during admission and upon discharge from hospital and phase II outpatient interventions. This study explores the impact of pharmacists' interventions in the early stages of CRP on humanistic outcomes and follow-up at a referral hospital in Malaysia...
January 13, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28078357/intralesional-treatment-of-metastatic-melanoma-a-review-of-therapeutic-options
#14
REVIEW
Benjamin Weide, Dario Neri, Giuliano Elia
Intralesional therapy of melanoma patients with locally advanced metastatic disease is attracting increasing interest, not least due to its ability to lead to both direct tumor cell killing and the stimulation of both a local and a systemic immune response. An obvious pre-requisite for this type of approach is the presence of accessible metastases that are amenable to direct injection with the therapeutic agent of interest. Patients who present with these characteristics belong to stages IIIB/C or IV of the disease...
January 11, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28076771/screening-and-prioritization-of-micropollutants-in-wastewaters-from-on-site-sewage-treatment-facilities
#15
Meritxell Gros, Kristin M Blum, Henrik Jernstedt, Gunno Renman, Sara Rodríguez-Mozaz, Peter Haglund, Patrik L Andersson, Karin Wiberg, Lutz Ahrens
A comprehensive screening of micropollutants was performed in wastewaters from on-site sewage treatment facilities (OSSFs) and urban wastewater treatment plants (WWTPs) in Sweden. A suspect screening approach, using high resolution mass spectrometry, was developed and used in combination with target analysis. With this strategy, a total number of 79 micropollutants were successfully identified, which belong to the groups of per- and polyfluoroalkyl substances (PFASs), pesticides, phosphorus-containing flame retardants (PFRs) and pharmaceuticals and personal care products (PPCPs)...
December 30, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28076549/training-of-pharmacy-technicians-for-dispensing-drugs-in-primary-health-care
#16
Daniela Oliveira de Melo, Caroline Godoi Rezende da Costa Molino, Eliane Ribeiro, Nicolina Silvana Romano-Lieber
Few Brazilian articles discuss the importance of pharmacy technicians who offer direct assistance to patients. This paper describes an experience of the training of pharmacy technicians in drug dispensing. A descriptive, cross-sectional study was conducted in the primary healthcare setting. The technicians were trained by the pharmacist to advise patients at the time of drug dispensing and to screen cases that needed pharmaceutical consultation. Problems were identified by verifying the prescription and return date for dispensing the medication as well as through direct questioning of the patients...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28076546/pharmacist-s-contribution-to-the-promotion-of-access-and-rational-use-of-essential-medicines-in-sus
#17
Daniela Oliveira de Melo, Lia Lusitana Cardozo de Castro
Objective: to describe the pharmaceutical inclusion process in a Basic Health Unit multidisciplinary team and evaluate results related to rational use and promotion of access to essential medicines. Methods: This is a descriptive, cross-sectional study conducted in a primary care health unit in the city of São Paulo. Pharmacist's activities were evaluated regarding the service structure and organization and prescribing quality improvement, guidance method creation, and implementation of clinical pharmacy service...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28076244/the-need-to-systematically-evaluate-clinical-practice-guidelines
#18
Allen F Shaughnessy, Lisa Cosgrove, Joel R Lexchin
Clinical practice guidelines abound. The recommendations contained in these guidelines are used not only to make decisions about the care of individual patients but also as practice standards to rate physician "quality." Physicians' confidence in guidelines is based on the supposition that there is a rigorous, objective process for developing recommendations based on the best available evidence. Though voluntary standards for the development of guidelines exist, the process of guideline development is unregulated and the quality of many guidelines is low...
November 2016: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28073966/extended-stability-of-antimicrobial-agents-in-administration-devices
#19
Abi Jenkins, Tim Hills, Mark Santillo, Mark Gilchrist
BACKGROUND: Outpatient parenteral antimicrobial therapy (OPAT) is an established approach to patient care. A lack of data on antimicrobial stability within administration devices is a barrier to service expansion, and poses an antimicrobial stewardship dilemma. Often broad-spectrum, long half-life agents are used instead of narrow-spectrum agents, which need more frequent administration, but could possibly be used if stability data were available. OBJECTIVES: To complete a comprehensive literature review of published antimicrobial stability data, and assess these against a nationally recognized minimum dataset for medicines compounded into administration devices...
January 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28073640/pharmaceuticals-in-a-temperate-forest-water-reuse-system
#20
Andrew D McEachran, Damian Shea, Elizabeth Guthrie Nichols
Forest-water reuse systems infiltrate municipal, industrial, and agricultural wastewaters through forest soils to shallow aquifers that ultimately discharge to surface waters. Their ability to mitigate regulated nutrients, metals, and organic chemicals is well known, but the fate of non-regulated chemicals in these systems is largely unstudied. This study quantified 33 pharmaceuticals and personal care products (PPCPs) in soils, groundwaters, and surface waters in a 2000-hectare forest that receives ~1200mm/year of secondary-treated, municipal wastewater in addition to natural rainfall (~1300mm/year)...
January 8, 2017: Science of the Total Environment
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