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https://www.readbyqxmd.com/read/29223784/thalidomide-attenuates-development-of-morphine-dependence-in-mice-by-inhibiting-pi3k-akt-and-nitric-oxide-signaling-pathways
#1
Muhammad Imran Khan, Majid Momeny, Sattar Ostadhadi, Samane Jahanabadi, Shahram Ejtemaee-Mehr, Bilqees Sameem, Ghazaleh Zarrinrad, Ahmad Reza Dehpour
Morphine dependence and the subsequent withdrawal syndrome restrict its clinical use in management of chronic pain. The precise mechanism for the development of dependence is still elusive. Thalidomide is a glutamic acid derivative, recently has been reconsidered for its clinical use due to elucidation of different clinical effects. Phosphoinositide 3-kinase (PI3K) is an intracellular transducer enzyme which activates Akt which in turns increases the level of nitric oxide. It is well established that elevated levels of nitric oxide has a pivotal role in the development of morphine dependence...
December 6, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29222646/evidence-for-the-involvement-of-opioid-system-in-the-antidepressant-like-effect-of-ascorbic-acid
#2
Morgana Moretti, Camille M Ribeiro, Vivian B Neis, Luis Eduardo B Bettio, Priscila B Rosa, Ana Lúcia S Rodrigues
Considering the involvement of the opioid system in major depressive disorder (MDD), mainly concerning refractory MDD, and the evidence that ascorbic acid may exert a beneficial effect for the treatment of this disorder, this study investigated the involvement of the opioid system in the antidepressant-like effect of ascorbic acid in the tail suspension test (TST). Treatment of Swiss mice with the non-selective opioid receptor antagonist naloxone (1 mg/kg, i.p.) prevented the reduced immobility time caused by ascorbic acid (1 mg/kg, p...
December 8, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29215840/rethinking-naloxone-overdose-drug-is-only-one-part-of-the-cycle-of-narcotic-abuse
#3
Neal J Richmond
No abstract text is available yet for this article.
February 2017: JEMS: a Journal of Emergency Medical Services
https://www.readbyqxmd.com/read/29206644/antinociceptive-and-antioxidant-activities-of-hunteria-umbellata-stem-bark-possible-role-of-the-serotonergic-opioidergic-and-dopaminergic-pathways
#4
Osaze Edosuyi, Ighodaro Igbe, Loretta Oghenekome Iniaghe
Background Hunteria umbellata (HU) (K. Schum) is used in ethnomedicine for the management of pain, diabetes mellitus and dysmenorrhoea. This study evaluated the analgesic and antioxidant activities of aqueous extract of HU stem bark and the possible mechanism(s) of action. Methods The antinociceptive effect of HU was evaluated using acetic acid mouse writhing, tail flick, hot plate and formalin-induced paw licking models. To establish the possible mechanism(s) of action of HU, separate group of animals were pretreated with naloxone (1 mg/kg, i...
December 5, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29200909/the-efficacy-of-combination-treatment-of-gabapentin-and-electro-acupuncture-on-paclitaxel-induced-neuropathic-pain
#5
Min Joon Kim, Ji Hwan Lee, Jo Ung Jang, Fu Shi Quan, Sun Kwang Kim, Woojin Kim
Paclitaxel, a chemotherapeutic drug, induces severe peripheral neuropathy. Gabapentin (GBT) is a first line agent used to treat neuropathic pain, and its effect is mediated by spinal noradrenergic and muscarinic cholinergic receptors. Electro-acupuncture (EA) is used for treating various types of pain via its action through spinal opioidergic and noradrenergic receptors. Here, we investigated whether combined treatment of these two agents could exert a synergistic effect on paclitaxel-induced cold and mechanical allodynia, which were assessed by the acetone drop test and von Frey filament assay, respectively...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29199028/sex-dependent-influences-of-morphine-and-its-metabolites-on-pain-sensitivity-in-the-rat
#6
H H Doyle, A Z Murphy
Preclinical studies report that the effective dose for morphine is approximately 2-fold higher in females than males. Following systemic administration, morphine is metabolized via Phase II glucuronidation in the liver and brain into two active metabolites: morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G), each possessing distinct pharmacological profiles. M6G binds to μ opioid receptors and acts as a potent analgesic. In contrast, M3G binds to toll-like receptor 4 (TLR4), initiating a neuroinflammatory response that directly opposes the analgesic effects of morphine and M6G...
November 30, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29198489/opiate-use-disorders-and-overdose-medical-students-experiences-satisfaction-with-learning-and-attitudes-toward-community-naloxone-provision
#7
H Tobin, J Klimas, T Barry, M Egan, G Bury
INTRODUCTION: Opiate use disorder is a common condition in healthcare services in Ireland, where over 200 opiate overdose deaths occur annually. There is limited addiction medicine education at undergraduate level and medical graduates may not be adequately prepared to diagnose and manage opioid use disorders and emergency drug overdose presentations. Therefore, we examined final-year medical students' learning experiences and attitudes toward opioid use disorder, overdose and community naloxone provision as an emerging overdose treatment...
November 22, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/29195596/group-based-treatment-of-opioid-use-disorder-with-buprenorphine-a-systematic-review
#8
Randi Sokol, Amy E LaVertu, Diana Morrill, Chiara Albanese, Zev Schuman-Olivier
BACKGROUND: Opioid use disorder (OUD) has become a public health crisis in the U.S., and there is a need to develop effective clinical treatment strategies. Coupling buprenorphine/naloxone (B/N) maintenance with counseling is encouraged as a best practice, yet the efficacy research on individual counseling in B/N-based Office-Based Opioid Treatment (OBOT) has been equivocal to date. In contrast, models for integrating B/N prescribing through group-based counseling could potentially have a differential impact, yet no systematic reviews have focused on examining the extent of the literature on group-based models of B/N delivery...
January 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29195592/understanding-abuse-of-buprenorphine-naloxone-film-versus-tablet-products-using-data-from-asi-mv%C3%A2-substance-use-disorder-treatment-centers-and-radars%C3%A2-system-poison-centers
#9
Stephen F Butler, Ryan A Black, Stevan Geoffrey Severtson, Richard C Dart, Jody L Green
OBJECTIVES: The objectives were to examine the abuse prevalence and route-of-administration (ROA) profiles of sublingual buprenorphine/naloxone combination (BNX) film in comparison with the BNX tablet and to identify clinically-relevant subgroups of patients or geographic patterns. METHODS: Between Q1 2015 through Q3 2015, data were collected from two major surveillance systems: (1) assessment of individuals in substance use disorder (SUD) treatment collected from the National Addictions Vigilance Intervention and Prevention Program (NAVIPPRO®) ASI-MV® system and (2) intentional abuse/misuse exposures in the RADARS® System Poison Center Program...
January 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29195589/factors-associated-with-naloxone-administration-in-an-opioid-dependent-sample
#10
Shannon R Kenney, Bradley J Anderson, Genie L Bailey, Michael D Stein
INTRODUCTION: Naloxone is a safe and effective antidote for reversing opioid overdose. Layperson administration of naloxone is increasingly common, yet little is known about demographic and clinical factors associated with opioid users' likelihood of having administered naloxone to another opioid user who had overdosed. We examined predictors of reported naloxone administration in the past year. METHODS: Four hundred and sixty-eight patients were interviewed upon admission to brief, inpatient opioid detoxification between May and December of 2015...
January 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29194445/safety-and-efficacy-of-an-oxycodone-vaccine-addressing-some-of-the-unique-considerations-posed-by-opioid-abuse
#11
M D Raleigh, S J Peterson, M Laudenbach, F Baruffaldi, F I Carroll, S D Comer, H A Navarro, T L Langston, S P Runyon, S Winston, M Pravetoni, P R Pentel
Among vaccines aimed at treating substance use disorders, those targeting opioids present several unique medication development challenges. 1) Opioid overdose is a common complication of abuse, so it is desirable for an opioid vaccine to block the toxic as well as the addictive effects of opioids. 2) It is important that an opioid vaccine not interfere with the action of opioid antagonists used to reverse opioid overdose or treat addiction. 3) Some opioids are immunosuppressive and chronic ongoing opioid use could interfere with vaccine immunogenicity...
2017: PloS One
https://www.readbyqxmd.com/read/29192123/the-slowly-signaling-g-protein-biased-cb2-cannabinoid-receptor-agonist-ly2828360-suppresses-neuropathic-pain-with-sustained-efficacy-and-attenuates-morphine-tolerance-and-dependence
#12
Xiaoyan Lin, Amey S Dhopeshwarkar, Megan Huibregtse, Ken Mackie, Andrea G Hohmann
The CB2 cannabinoid agonist LY2828360 lacked both toxicity and efficacy in a clinical trial for osteoarthritis. Whether LY2828360 suppresses neuropathic pain has not been reported and its signaling profile is unknown. In vitro, LY2828360 was a slowly acting but efficacious G protein-biased CB2 agonist, inhibiting cAMP accumulation and activating ERK1/2 signaling while failing to recruit arrestin, activate inositol phosphate signaling or internalize CB2 receptors. In wildtype (WT) mice, LY2828360 (3 mg/kg/day i...
November 30, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/29189517/can-early-oral-prolonged-release-oxycodone-with-or-without-naloxone-reduce-the-duration-of-epidural-analgesia-after-cystectomy-a-three-arm-randomized-double-blind-placebo-controlled-trial
#13
Marc P Schneider, Lukas M Löffel, Marc A Furrer, Fiona C Burkhard, Bettina Kleeb, Michele Curatolo, Patrick Y Wuethrich
Thoracic epidural analgesia (TEA) enhances recovery after bowel surgery. Early postoperative prolonged-release oral formulation of oxycodone or oxycodone/naloxone is potentially useful as a second analgesic step to reduce the duration of TEA. We hypothesized that oxycodone would decrease the duration of TEA and combined with naloxone preserve gastrointestinal function. Ninety patients undergoing open cystectomy and urinary diversion were enrolled in this randomized double-blind, three-arm, parallel-group, placebo-controlled single-center trial between September 2015 and February 2017...
November 20, 2017: Pain
https://www.readbyqxmd.com/read/29186992/evaluation-of-the-southern-harm-reduction-coalition-for-hiv-prevention-advocacy-accomplishments
#14
Chandra R Story, Wei-Kang Kao, Joe Currin, Colton Brown, Vignetta Charles
BACKGROUND: HIV/AIDS rates are higher in the Southern United States compared to other regions of the country. Reasons for disparities include poverty, health care access, and racism. People who inject drugs (PWID) account for 8% of HIV/AIDS incidence rates. Harm reduction can connect PWID to needed resources. AIDS United Southern REACH grantees developed the Southern Harm Reduction Coalition (SHRC) as a means to decrease HIV/AIDS and viral hepatitis rates, criminalization of drug users and sex workers, and drug overdose...
November 1, 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/29183278/capnography-sensor-use-is-associated-with-reduction-of-adverse-outcomes-during-gastrointestinal-endoscopic-procedures-with-sedation-administration
#15
Michael W Jopling, Jiejing Qiu
BACKGROUND: Evidence to date suggests that capnography monitoring during gastrointestinal endoscopic procedures (GEP) reduces the incidence of hypoxemia, but the association of capnography monitoring with the incidence of other adverse outcomes surrounding these procedures has not been well studied. Our aims were to estimate the incidence of pharmacological rescue events and death at discharge from an inpatient or outpatient hospitalization where GEP was performed with sedation, and to determine if capnography monitoring was associated with reduced incidence of these adverse outcomes...
November 28, 2017: BMC Anesthesiology
https://www.readbyqxmd.com/read/29182612/nucleus-accumbens-local-field-potential-power-spectrums-phase-amplitude-couplings-and-coherences-following-morphine-treatment
#16
Chayaporn Reakkamnuan, Dania Cheaha, Ekkasit Kumarnsit
In the past decade, neural processing has been extensively studied in cognitive neuroscience. However, neural signaling in the nucleus accumbens (NAc) that might clarify reward process remained to be investigated. Male Swiss albino ICR mice implanted with intracranial electrodes into the NAc and the ventral tegmental area (VTA) were used for morphine administration and local field potential (LFP) recording. One-way ANOVA revealed significant increases in low (30.3-44.9 Hz) and high (60.5-95.7 Hz) gamma powers in the NAc following morphine administration (5 and 15 mg/kg, i...
2017: Acta Neurobiologiae Experimentalis
https://www.readbyqxmd.com/read/29181541/emergency-medical-services-naloxone-administration-many-unknowns-and-opportunities
#17
Elizabeth M Oliva, Mark Bounthavong
No abstract text is available yet for this article.
November 28, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29181532/management-of-suspected-opioid-overdose-with-naloxone-in-out-of-hospital-settings-a-systematic-review
#18
Roger Chou, P Todd Korthuis, Dennis McCarty, Phillip O Coffin, Jessica C Griffin, Cynthia Davis-O'Reilly, Sara Grusing, Mohamud Daya
Background: Naloxone is effective for reversing opioid overdose, but optimal strategies for out-of-hospital use are uncertain. Purpose: To synthesize evidence on 1) the effects of naloxone route of administration and dosing for suspected opioid overdose in out-of-hospital settings on mortality, reversal of overdose, and harms, and 2) the need for transport to a health care facility after reversal of overdose with naloxone. Data Sources: Ovid MEDLINE (1946 through September 2017), PsycINFO, Cochrane Central Register of Controlled Trials, CINAHL, U...
November 28, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29180889/risk-of-respiratory-depression-with-opioids-and-concomitant-gabapentinoids
#19
Julie Savelloni, Heather Gunter, Kelly C Lee, Chih Hsu, Cassia Yi, Kyle P Edmonds, Timothy Furnish, Rabia S Atayee
Introduction: The combination of opioids and central nervous system depressants such as benzodiazepines and barbiturates has an additive effect on the frequency of oversedation and respiratory depression requiring naloxone use in hospitalized patients. Gabapentinoids (gabapentin and pregabalin) are frequently prescribed with opioids for their opioid-sparing and adjuvant analgesic effects. There is limited literature on the risk of respiratory depression due to the combination of opioids and gabapentinoids requiring naloxone administration...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/29177439/attitudes-beliefs-practices-and-concerns-among-clinicians-prescribing-opioids-in-a-large-academic-institution
#20
Jon O Ebbert, Lindsey M Philpot, Casey M Clements, Jenna K Lovely, Wayne T Nicholson, Sarah M Jenkins, Tim J Lamer, Halena M Gazelka
Objectives: Opioid treatment of chronic noncancer pain (CNCP) adds complexity and uncertainty to patient interactions. We sought to assess clinician attitudes, beliefs, practice styles, and concerns around opioid prescribing following the release of the US Centers for Disease Control and Prevention (CDC) guideline for prescribing opioids for chronic pain. Methods: E-mailed electronic survey to clinicians at a large academic medical institution. Results: A total of 961 clinicians responded to the survey (response rate = 40%), 720 of whom prescribed opioids and were not in training...
June 15, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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