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Kleine-levin syndrome

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https://www.readbyqxmd.com/read/27538325/-clinical-investigation-of-an-excessive-sleepiness-complaint
#1
Elisa Evangelista, Lucie Barateau, Yves Dauvilliers
Excessive sleepiness is a common problem, defined by a complaint of excessive daytime sleepiness almost daily with an inability to stay awake and alert dosing periods at sleep, with episodes of irresistible sleep need or drowsiness or non-intentional sleep, or by a night's sleep time overly extended often associated with sleep inertia. This sleepiness is variable in terms of phenotype and severity to be specified by the out-patient clinic. It is considered to be chronic beyond three months and often responsible for significant functional impairment of school and professional performance, of the accidents and cardiovascular risk...
June 2016: La Revue du Praticien
https://www.readbyqxmd.com/read/27484420/-kleine-levin-syndrome-more-than-just-periodic-hypersomnia
#2
S Pillen, N L E Vandenbussche, R Fronczek, J van Duijn, G J Lammers, S Overeem
BACKGROUND: Kleine Levin Syndrome (KLS) is a rare disease with periodic hypersomnia as its main feature. Hyperphagia and hypersexuality are also described as classical symptoms, although quite recently it has become clear that the full triad is absent in the majority of patients. CASE DESCRIPTION: A 14-year-old boy developed KLS after a period of flu-like symptoms. Over the course of three years he suffered from seven one-week episodes of extreme hypersomnia (sleeping 18 hours a day), depersonalisation, apathy, anxiety, paranoia, confusion, hallucinations and uninhibited sexual behaviour...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27364793/a-polysomnography-study-of-kleine-levin-syndrome-in-a-single-center
#3
Yan-Wen Luo, Huan Yu, Lu-Hua Yuan, Guo-Xing Zhu
BACKGROUND: Kleine-Levin syndrome (KLS) is a rare sleep disorder characterized by recurrent episodes of hypersomnia. Polysomnographic (PSG) researches of KLS have been reported only in few publications in the past decades. This study aimed to investigate the characteristics of PSG of KLS. METHODS: This study, which was conducted from March 2010 to July 2014, included seven patients diagnosed with KLS in the Sleep and Wake Disorder Center of Huashan Hospital, Fudan University (Shanghai, China)...
July 5, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27343267/migraine-with-brainstem-aura-presenting-as-recurrent-hypersomnia-kleine-levin-syndrome
#4
Alexander D Nesbitt, Guy D Leschziner
Recurrent hypersomnia, or Kleine-Levin syndrome, is rare and frequently causes substantial diagnostic anxiety and delay. Patients often undergo multiple investigations to rule out other causes of encephalopathy. The treatment options are unsatisfactory. Migraine with brainstem aura has not previously been widely considered in the medical literature as a differential diagnosis. We describe two patients referred to a tertiary sleep neurology service with a putative diagnosis of Kleine-Levin syndrome. Each described attacks of hypersomnia with elements of migraine with brainstem aura, in addition to having a history of migraine with aura...
October 2016: Practical Neurology
https://www.readbyqxmd.com/read/27253765/familial-kleine-levin-syndrome-a-specific-entity
#5
Quang Tuan Remy Nguyen, Elisabeth Groos, Laurène Leclair-Visonneau, Christelle Monaca-Charley, Tom Rico, Neal Farber, Emmanuel Mignot, Isabelle Arnulf
STUDY OBJECTIVES: Kleine-Levin syndrome (KLS) is a rare, mostly sporadic disorder, characterized by intermittent episodes of hypersomnia plus cognitive and behavior disorders. Although its cause is unknown, multiplex families have been described. We contrasted the clinical and biological features of familial versus sporadic KLS. METHODS: Two samples of patients with KLS from the United States and France (n = 260) were studied using clinical interviews and human leukocyte antigen (HLA) genotyping...
2016: Sleep
https://www.readbyqxmd.com/read/27250808/prevalence-and-mimics-of-kleine-levin-syndrome-a-survey-in-french-speaking-switzerland
#6
Oussama Habra, Raphaël Heinzer, Jose Haba-Rubio, Andrea O Rossetti
STUDY OBJECTIVE: Kleine-Levin syndrome (KLS) is a rare disease of unknown etiology, the diagnosis of which can be challenging. We aimed to estimate KLS prevalence in French-speaking Switzerland, and assess differences with mimicking conditions. METHODS: In this cross-sectional study, KLS patients were identified through a population-based approach, including at our hospital and contacting all sleep-certified facilities and neurologists in French-speaking Switzerland...
2016: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/27230978/new-hypothesis-on-pontine-frontal-eye-field-connectivity-in-kleine-levin-syndrome
#7
Maria Engström, Anne-Marie Landtblom, Thomas Karlsson
Previous studies have indicated involvement of the thalamus and the pons in Kleine-Levin syndrome. In the present study, functional connectivity of the thalamus and the pons was investigated in asymptomatic patients with Kleine-Levin syndrome and healthy controls. Twelve patients and 14 healthy controls were investigated by functional magnetic resonance imaging during rest. Resting state images were analysed using seed regions of interest in the thalamus and the pons. The results showed significantly lower functional connectivity between the pons and the frontal eye field in persons with Kleine-Levin syndrome compared with healthy controls...
May 27, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/27153153/pharmacological-treatment-for-kleine-levin-syndrome
#8
REVIEW
Marcio M de Oliveira, Cristiane Conti, Gilmar F Prado
BACKGROUND: This is an updated version of the original Cochrane review, published in 2009, Issue 2.Kleine-Levin syndrome (KLS) is a rare disorder that mainly affects adolescent men. It is characterised by recurrent episodes of hypersomnia, usually accompanied by hyperphagia, cognitive and mood disturbances, abnormal behaviour, such as hypersexuality, and signs of dysautonomia.In 1990, the diagnostic criteria for Kleine-Levin syndrome were modified in the International Classification of Sleep Disorders, where KLS was defined as a syndrome comprised of recurring episodes of undue sleepiness lasting some days, which may or may not be associated with hyperphagia and abnormal behaviour...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27137943/kleine-levin-syndrome
#9
REVIEW
Mitchell G Miglis, Christian Guilleminault
Kleine-Levin syndrome is a rare recurrent hypersomnia associated with symptoms of behavioral and cognitive impairment. This article reviews common presenting symptoms, differential diagnosis, diagnostic workup, and potential treatment options. Current updates on functional imaging studies and long-term neuropsychological studies are reviewed.
June 2016: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/27073070/kleine-levin-syndrome
#10
REVIEW
Oliver Sum-Ping, Christian Guilleminault
Kleine-Levin Syndrome [KLS] is often under-recognized and also misdiagnosed. When suspicion for KLS is raised, a thorough clinical evaluation should be performed, including detailed history from family members and a neurologic and psychiatric examination. Additional studies may include PSG, EEG, neuroimaging, as well as serological and CSF studies to rule out alternative diagnoses as clinically indicated. After arriving at a diagnosis of KLS, the foundation of care is supportive. Patients and their families should be provided with education about the disease...
June 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/26989535/the-kleine-levin-syndrome-a-rare-disease-with-often-delayed-diagnosis-a-report-of-two-cases-in-the-department-of-neurology-of-the-university-hospital-of-cocody-c%C3%A3-te-d-ivoire
#11
Berthe Assi, Constance Yapo-Ehounoud, Mohamed Ben Allaoui Baby, Evelyne Aka-Diarra, Muriel Amon-Tanoh, Christian Tanoh
The Kleine-Levin syndrome is a rare pathology characterized by recurrent episodes of hypersomnia associated with behavioral and cognitive disorders with, among others, hyperphagia and hypersexuality. The disease mainly affects young males. A few studies mention cases that occurred in Africa, especially in Côte d'Ivoire. In this paper, we report the very first two cases observed in the Neurology Department of the University Hospital of Cocody. The diagnosis was clinical, based on the recurrence of hypersomnia, cognitive and behavioral disorders during the periods of hypersomnia, and the return of patients to normal state between episodes...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/26943469/cerebrospinal-fluid-orexin-a-levels-and-autonomic-function-in-kleine-levin-syndrome
#12
Jing Yu Wang, Fang Han, Song X Dong, Jing Li, Pei An, Xiao Zhe Zhang, Yuan Chang, Long Zhao, Xue Li Zhang, Ya Nan Liu, Han Yan, Qing Hua Li, Yan Hu, Chang Jun Lv, Zhan Cheng Gao, Kingman P Strohl
STUDY OBJECTIVES: Kleine-Levin syndrome (KLS) is a rare disorder of relapsing sleepiness. The hypothesis was that the syndrome is related to a change in the vigilance peptide orexin A. METHODS: From 2002 to 2013, 57 patients with relapsing hypersomnolence were clinically assessed in a referral academic center in Beijing, China, and 44 (28 males and 16 females; mean age 18.3 ± 8.9 y (mean ± standard deviation, range 9-57 y) were determined to have clinical and behavioral criteria consistent with KLS...
April 1, 2016: Sleep
https://www.readbyqxmd.com/read/26935190/kleine-levin-syndrome-an-overview-and-relevance-to-nursing-practice
#13
Jacqueline M Arnone, Richard P Conti
Kleine-Levin syndrome (KLS) is a neuropsychiatric sleep disorder primarily affecting adolescent males. Onset is insidious, idiopathic, and hastened by neurological incident or infection. Typically, the initial onset occurs during the teen years or after the second decade, although cases have been documented in early childhood, adulthood, and senescence. KLS is marked by unexpected debilitating, yet reversible, episodic hypersomnia, with varying recurrence rates; cognitive and behavioral impairment; compulsive eating; and feelings of derealization, hypersexuality, apathy, and depressed mood...
March 2016: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/26922652/anti-n-methyl-d-aspartate-receptor-encephalitis-presenting-with-features-of-kleine-levin-syndrome-and-demyelination
#14
Jacob Feigal, Chen Lin, George Barrio, Peter G Kranz, Xavier Preud׳Homme
No abstract text is available yet for this article.
May 2016: Psychosomatics
https://www.readbyqxmd.com/read/26739970/kleine-levin-syndrome-familial-cases-and-comparison-with-sporadic-cases
#15
Saad M Al Suwayri
OBJECTIVES: To highlight the occurrence of familial cases and addresses, whether familial Kleine-Levine syndrome (KLS) presents the same spectrum of disease, as that seen in sporadic KLS.   METHODS: Between September and December 2014, reports of familial cases of KLS were identified by searching the Library of Congress, PubMed, and Web of Science databases restricted to the English language, with no restriction on date of publication. All cases were reviewed to identify familial cases consistent with current diagnostic criteria for sporadic KLS...
January 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/26664444/kleine-levin-syndrome-in-an-8-year-old-girl-with-autistic-disorder-does-autism-account-a-primary-or-secondary-cause
#16
Mitra Hakim Shoushtari, Mirfarhad Ghalebandi, Azita Tavasoli, Maryam Pourshams
Objective Kleine-Levin syndrome (KLS) is a rare disorder with an unknown etiology. Autism spectrum disorder is characterized by various degrees of impairment in social communication, repetitive behavior and restricted interests. Only four patients of KLS with autistic spectrum disorder (ASD) have been reported so far. This report presents an 8-year-old girl with history of autistic disorder and epilepsy that superimposed KLS. Because of the rarity of KLS and related studies did not address whether autism accounts for a primary or secondary cause, the area required attention further studies...
2015: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/26664089/successful-use-of-valproate-in-kleine-levin-syndrome-a-case-report-and-review-of-cases-reported-from-india
#17
Naresh Nebhinani, Ajit Avasthi, Manish Modi
Kleine-Levin syndrome (KLS) is characterized by recurrent episodes of hypersomnia and other symptoms and it is a really challenging for the physician, since its causes are not yet clear, and available treatment options are not having adequate support. Here, we are reporting a case with successful use of valproate in KLS and also reviewing the cases reported from India.
July 2015: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/26634130/kleine-levin-syndrome-with-comorbid-iron-deficiency-anemia
#18
Rajendra Singh Jain, Sunil Kumar, Trilochan Srivastava, Raghavendra Bakki Sannegowda
Kleine-Levin syndrome (KLS) is a rare chronic sleep disorder of unknown etiopathology, which typically occurs in adolescent males. Although the severity of symptoms and disease course varies between the KLS patients, it usually resolves spontaneously, but sometime comorbid conditions may worsen the symptoms. Herein, we report a case of KLS who presented with severe episodic hypersomnia. During episodes, the patient used to sleep as long as 20 h in a day, affecting his daily living activities. All the relevant investigations including electroencephalography, magnetic resonance imaging of brain and cerebrospinal fluid analysis were normal except for severe iron deficiency anemia (IDA)...
March 2015: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/26562572/do-the-symptoms-of-kleine-levin-syndrome-correlate-with-the-hypometabolism-of-the-thalamus-on-fdg-pet
#19
Hongjun Xie, Jia Guo, Hao Liu, Wenzhong Song
A 15-year-old adolescent boy had experienced intermittent, recurrent hypersomnia lasting for 1 week to 3 weeks for more than 3 years. He was diagnosed with Kleine-Levin Syndrome clinically. The brain MRI, video EEG, and serum and cerebrospinal fluid analysis did not show any abnormality. An FDG PET/CT scanning was acquired when the patient was symptomatic, showing marked symmetric hypometabolism in the thalamus and hypothalamus in the symptomatic phase, as well as mild homogeneous decreased glucose metabolism in the cortex...
March 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/26528660/recommended-treatment-strategies-for-patients-with-excessive-daytime-sleepiness
#20
REVIEW
Russell P Rosenberg
Excessive daytime sleepiness (EDS) is a common and bothersome phenomenon. It can be associated with insufficient sleep syndrome, narcolepsy, idiopathic hypersomnia, obstructive sleep apnea, shift work disorder, Kleine-Levin syndrome, or Parkinson's disease. Once the underlying cause of the excessive sleepiness is determined, clinicians must select the most appropriate behavioral and pharmacologic interventions to reduce daytime sleepiness, alleviate other symptoms, improve functioning, and ensure the safety of patients and those around them...
October 2015: Journal of Clinical Psychiatry
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