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https://www.readbyqxmd.com/read/29334197/increased-non-aids-mortality-among-persons-with-aids-defining-events-after-antiretroviral-therapy-initiation
#1
April C Pettit, Mark J Giganti, Suzanne M Ingle, Margaret T May, Bryan E Shepherd, Michael J Gill, Gerd Fätkenheuer, Sophie Abgrall, Michael S Saag, Julia Del Amo, Amy C Justice, Jose M Miro, Matthias Cavasinni, François Dabis, Antonella D Monforte, Peter Reiss, Jodie Guest, David Moore, Leah Shepherd, Niels Obel, Heidi M Crane, Colette Smith, Ramon Teira, Robert Zangerle, Jonathan Ac Sterne, Timothy R Sterling
INTRODUCTION: HIV-1 infection leads to chronic inflammation and to an increased risk of non-AIDS mortality. Our objective was to determine whether AIDS-defining events (ADEs) were associated with increased overall and cause-specific non-AIDS related mortality after antiretroviral therapy (ART) initiation. METHODS: We included HIV treatment-naïve adults from the Antiretroviral Therapy Cohort Collaboration (ART-CC) who initiated ART from 1996 to 2014. Causes of death were assigned using the Coding Causes of Death in HIV (CoDe) protocol...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29316564/primary-prevention-of-stroke-in-chronic-kidney-disease-patients-a-scientific-update
#2
Stefana Catalina Bilha, Alexandru Burlacu, Dimitrie Siriopol, Luminita Voroneanu, Adrian Covic
BACKGROUND: Although chronic kidney disease (CKD) is an independent risk factor for stroke, official recommendations for the primary prevention of stroke in CKD are generally lacking. SUMMARY: We searched PubMed and ISI Web of Science for randomised controlled trials, observational studies, reviews, meta-analyses and guidelines referring to measures of stroke prevention or to the treatment of stroke-associated risk factors (cardiovascular disease in general and atrial fibrillation (AF), arterial hypertension or carotid artery disease in particular) among the CKD population...
January 9, 2018: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/29304747/adipokines-levels-in-hiv-infected-patients-lipocalin-2-and-fatty-acid-binding-protein-4-as-possible-markers-of-hiv-and-antiretroviral-therapy-related-adipose-tissue-inflammation
#3
Mario Luca Morieri, Viola Guardigni, Juana Maria Sanz, Edoardo Dalla Nora, Cecilia Soavi, Giovanni Zuliani, Laura Sighinolfi, Angelina Passaro
BACKGROUND: Metabolic and cardiovascular diseases (CVD) represent a major problem in HIV infection. The aim of this study was to evaluate the relationship of HIV infection and antiretroviral therapy (ART) with circulating levels of two adipokines (Lipocalin-2 and Fatty Acid Binding Protein-4, FABP-4), known to be associated with adipose tissue dysfunction and cardiovascular disease in the general population. METHODS: We enrolled 40 non-obese HIV-infected patients and 10 healthy controls of similar age and Body Mass Index (BMI)...
January 5, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29290955/effect-of-antiretroviral-therapy-use-and-adherence-on-the-risk-of-hyperlipidemia-among-hiv-infected-patients-in-the-highly-active-antiretroviral-therapy-era
#4
Fuu-Jen Tsai, Chi-Fung Cheng, Chih-Ho Lai, Yang-Chang Wu, Mao-Wang Ho, Jen-Hsien Wang, Ni Tien, Xiang Liu, Hsinyi Tsang, Ting-Hsu Lin, Chiu-Chu Liao, Shao-Mei Huang, Ju-Pi Li, Jung-Chun Lin, Chih-Chien Lin, Jin-Hua Chen, Wen-Miin Liang, Ying-Ju Lin
HIV-infected patients exposed to antiretroviral therapy (ART) have an increased risk for hyperlipidemia and cardiovascular disease. We performed a longitudinal, comprehensive, and population-based study to investigate the cumulative effect of different types of ART regimens on hyperlipidemia risk in the Taiwanese HIV/ART cohort. A total of 13,370 HIV-infected patients (2,674 hyperlipidemia and 10,696 non-hyperlipidemia patients) were recruited after matching for age, gender, and the first diagnosis date of HIV infection by using the National Health Insurance Research Database in Taiwan...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29246206/the-association-between-hiv-and-atherosclerotic-cardiovascular-disease-in-sub-saharan-africa-a-systematic-review
#5
Emily P Hyle, Bongani M Mayosi, Keren Middelkoop, Mosepele Mosepele, Emily B Martey, Rochelle P Walensky, Linda-Gail Bekker, Virginia A Triant
BACKGROUND: Sub-Saharan Africa (SSA) has confronted decades of the HIV epidemic with substantial improvements in access to life-saving antiretroviral therapy (ART). Now, with improved survival, people living with HIV (PLWH) are at increased risk for non-communicable diseases (NCDs), including atherosclerotic cardiovascular disease (CVD). We assessed the existing literature regarding the association of CVD outcomes and HIV in SSA. METHODS: We used the PRISMA guidelines to perform a systematic review of the published literature regarding the association of CVD and HIV in SSA with a focus on CVD surrogate and clinical outcomes in PLWH...
December 15, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29223466/long-term-pulmonary-and-cardiovascular-morbidities-of-neonatal-hyperoxia-exposure-in-mice
#6
Renuka T Menon, Amrit Kumar Shrestha, Corey L Reynolds, Roberto Barrios, Binoy Shivanna
Pulmonary hypertension (PH) frequently occurs in infants with bronchopulmonary dysplasia (BPD), causing increased mortality and right ventricular (RV) dysfunction that persists into adulthood. A first step in developing better therapeutic options is identifying and characterizing an appropriate animal model. Previously, we characterized the short-term morbidities of a model in which C57BL/6J wild-type (WT) mice were exposed to 70% O2 (hyperoxia) during the neonatal period. Here, we aimed to determine the long-term morbidities using lung morphometry, echocardiography (Echo), and cardiac magnetic resonance imaging (cMRI)...
December 7, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/29189659/high-prevalence-of-lipid-abnormalities-and-insulin-resistance-among-antiretroviral-na%C3%A3-ve-hiv-infected-children-in-india
#7
Chandrasekaran Padmapriyadarsini, Anita Shet, Ramalingam Srinivasan, Geetha Ramachandran, G N Sanjeeva, Poornaganga Devi, Karunainathan Ramesh, Perumal Kannabiran Bhavani, Devaraj Reddy, Elumalai Suresh, Chockalingam Chandrasekhar, Christine Wanke, Soumya Swaminathan
BACKGROUND: As large numbers of children are accessing antiretroviral therapy (ART) in India, we evaluated the dietary intake, growth pattern and risk of metabolic complications like dyslipidemia and insulin resistance among ART-naïve HIV infected children (CLHIV). METHODS: CLHIV aged 2-12 years, at the time of initiating ART in Chennai and Bangalore, were assessed for their dietary intake, anthropometry, blood CD4 cell count, HIV-1 viral load, fasting serum lipids, glucose and insulin...
November 20, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29189172/cardiovascular-complications-of-human-immunodeficiency-virus-infection
#8
Daniela Sofia Martins Pinto, Manuel Joaquim Lopes Vaz da Silva
BACKGROUND: Since the introduction of antiretroviral therapy (ART), the life expectancy and health quality for patients infected with human immunodeficiency virus (HIV) have significantly improved. Nevertheless, as a result of not only the deleterious effects of the virus itself and prolonged ART, but also the effects of aging, cardiovascular diseases have emerged as one of the most common causes of death among these patients. OBJECTIVE: The purpose of this review is to explore the new insights on the spectrum of cardiovascular disease (CVD) in HIV infection, with emphasis on the factors that contribute to the atherosclerotic process and its role in the development of acute coronary syndrome in the setting of infection...
November 29, 2017: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29184046/decoding-resistant-hypertension-signalling-pathways
#9
REVIEW
Ricardo Cambraia Parreira, Leandro Heleno Guimarães Lacerda, Rebecca Vasconcellos, Swiany Silveira Lima, Anderson Kenedy Santos, Vanessa Fontana, Valéria Cristina Sandrim, Rodrigo Ribeiro Resende
Resistant hypertension (RH) is a clinical condition in which the hypertensive patient has become resistant to drug therapy and is often associated with increased cardiovascular morbidity and mortality. Several signalling pathways have been studied and related to the development and progression of RH: modulation of sympathetic activity by leptin and aldosterone, primary aldosteronism, arterial stiffness, endothelial dysfunction and variations in the renin-angiotensin-aldosterone system (RAAS). miRNAs comprise a family of small non-coding RNAs that participate in the regulation of gene expression at post-transcriptional level...
December 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29160505/metabolic-disorders-and-cardiovascular-risk-in-people-living-with-hiv-aids-without-the-use-of-antiretroviral-therapy
#10
Mariana Amaral Raposo, Geyza Nogueira de Almeida Armiliato, Nathalia Sernizon Guimarães, Camila Abrahão Caram, Raíssa Domingues de Simoni Silveira, Unaí Tupinambás
INTRODUCTION: Metabolic disorders in people living with HIV/AIDS (PLH) have been described even before the introduction of antiretroviral (ARV) drugs in the treatment of HIV infection and are risk factors for cardiovascular diseases. Based on this, the purpose of this study was to assess metabolic disorders and cardiovascular risk in PLH before the initiation of antiretroviral treatment (ART). METHODS: This was a cross-sectional descriptive study of 87 PLH without the use of ART, which was carried out between January and September 2012 at a specialized infectious diseases center in Minas Gerais, Brazil...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29159965/improvement-in-lipids-after-switch-to-boosted-atazanavir-or-darunavir-in-children-adolescents-with-perinatally-acquired-hiv-on-older-protease-inhibitors-results-from-the-pediatric-hiv-aids-cohort-study
#11
J Jao, W Yu, K Patel, T L Miller, B Karalius, M E Geffner, L A DiMeglio, A Mirza, J S Chen, M Silio, E J McFarland, R B Van Dyke, D Jacobson
OBJECTIVES: Dyslipidaemia is common in perinatally HIV-infected (PHIV) youth receiving protease inhibitors (PIs). Few studies have evaluated longitudinal lipid changes in PHIV youth after switch to newer PIs. METHODS: We compared longitudinal changes in fasting lipids [total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and TC:HDL-C ratio] in PHIV youth enrolled in the Pediatric HIV/AIDS Cohort Study (PHACS) Adolescent Master Protocol (AMP) study who switched to atazanavir/ritonavir (ATV/r)- or darunavir/ritonavir (DRV/r)-based antiretroviral therapy (ART) from an older PI-based ART and those remaining on an older PI...
November 21, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29135581/high-rates-of-hypertension-diabetes-elevated-low-density-lipoprotein-cholesterol-and-cardiovascular-disease-risk-factors-in-hiv-infected-patients-in-malawi
#12
Sekai C Mathabire Rücker, Alia Tayea, Joseph Bitilinyu-Bangoh, Elkin H Bermúdez-Aza, Leon Salumu, Isabel Amoros Quiles, Elisabeth Szumilin, Zengani Chirwa, Fernanda Rick, David Maman
OBJECTIVES: Data on cardiovascular disease risks among HIV-infected patients taking antiretroviral therapy (ART) over long periods of time are lacking in Sub-Saharan Africa. METHODS: A cross-sectional study was conducted in Chiradzulu, Malawi from December 2015 to June 2016. HIV-infected persons on ART for more than 10 years (patients) and HIV-negative individuals (controls) from selected clinics participated. Following informed consent, a standardized questionnaire, clinical and laboratory examinations were performed...
January 14, 2018: AIDS
https://www.readbyqxmd.com/read/29106789/depression-and-obstructive-sleep-apnea
#13
(no author information available yet)
OBJECTIVE: Obstructive sleep apnea (OSA), is described as intermittent interruptions or reductions in airflow which are initiated by an incomplete or complete collapse of the upper airways despite respiratory effort. When left untreated, OSA is connected with comorbid conditions, such as cardiovascular and metabolic illnesses. METHOD: The PubMed database was used to examine papers published until April 2017 using the subsequent terms: "obstructive sleep apnea" or "obstructive sleep apnoea" and "depression" in successive combination with "CPAP (continuous positive airway pressure)", "therapy", "pharmacotherapy", "psychotherapy", "cognitive behavioral therapy" or "quality of life"...
October 6, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29090191/coronary-heart-disease-risk-in-patients-with-schizophrenia-a-lebanese-cross-sectional-study
#14
Chadia Haddad, Souheil Hallit, Pascale Salameh, Tarek Bou-Assi, Marouan Zoghbi
BACKGROUND: Coronary heart disease (CHD) is a leading cause of premature death in patients with schizophrenia. CHD risk in Lebanese patients with schizophrenia remains unknown. OBJECTIVES: To (i) evaluate CHD risk of patients with schizophrenia in Lebanon; and (ii) detect the modifiable and non-modifiable factors affecting this risk. METHODS: Cross-sectional study of 329 patients with schizophrenia aged 20-75 years. Ten-year hard CHD risk was calculated using the Framingham risk score...
2017: Journal of Comorbidity
https://www.readbyqxmd.com/read/29081979/dual-antiplatelet-therapy-for-secondary-prevention-of-coronary-artery-disease
#15
REVIEW
Sophie Degrauwe, Thomas Pilgrim, Adel Aminian, Stephane Noble, Pascal Meier, Juan F Iglesias
Dual antiplatelet therapy (DAPT) combining aspirin and a P2Y12 receptor inhibitor has been consistently shown to reduce recurrent major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) or undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease (CAD) compared with aspirin monotherapy, but at the expense of an increased risk of major bleeding. Nevertheless, the optimal duration of DAPT for secondary prevention of CAD remains uncertain, owing to the conflicting results of several large randomised trials...
2017: Open Heart
https://www.readbyqxmd.com/read/29078761/risk-of-cardiovascular-events-from-current-recent-and-cumulative-exposure-to-abacavir-among-persons-living-with-hiv-who-were-receiving-antiretroviral-therapy-in-the-united-states-a-cohort-study
#16
Kunchok Dorjee, Sanjiv M Baxi, Arthur L Reingold, Alan Hubbard
BACKGROUND: There is ongoing controversy regarding abacavir use in the treatment of HIV infection and the risk of subsequent development of cardiovascular disease. It is unclear how the risk varies as exposure accumulates. METHODS: Using an administrative health-plan dataset, risk of cardiovascular disease events (CVDe), defined as the first episode of an acute myocardial infarction or a coronary intervention procedure, associated with abacavir exposure was assessed among HIV-infected individuals receiving antiretroviral therapy across the U...
October 27, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29067253/evidence-based-review-of-statin-use-in-patients-with-hiv-on-antiretroviral-therapy
#17
REVIEW
Daniel B Chastain, Kayla R Stover, Daniel M Riche
INTRODUCTION: As a result of improved safe and effective therapeutic options for human immunodeficiency virus (HIV), life expectancy of those living with HIV is increasing leading to new challenges (e.g., management of chronic diseases). Some chronic diseases (e.g., cardiovascular disease [CVD]), are up to two times more prevalent in patients with HIV. Statins are a mainstay of therapy for prevention of CVD; but, clinicians should be aware that not all statins are appropriate for use in the HIV population, especially those receiving antiretroviral therapy (ART)...
June 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29053758/sex-differences-in-long-term-mortality-among-acute-myocardial-infarction-patients-results-from-the-isar-risk-and-art-studies
#18
Romy Ubrich, Petra Barthel, Bernhard Haller, Katerina Hnatkova, Katharina Maria Huster, Alexander Steger, Alexander Müller, Marek Malik, Georg Schmidt
BACKGROUND: Mortality rates in females who survived acute myocardial infarction (AMI) exceed those in males. Differences between sexes in age, cardiovascular risk factors and revascularization therapy have been proposed as possible reasons. OBJECTIVE: To select sets of female and male patients comparable in respect of relevant risk factors in order to compare the sex-specific risk in a systematic manner. METHODS: Data of the ISAR-RISK and ART studies were investigated...
2017: PloS One
https://www.readbyqxmd.com/read/29044011/antiretroviral-therapy-and-arterial-elasticity-in-hiv-infected-patients
#19
Mariana A Kundro, Guillermo A Viloria, Javier J Toibaro, Marcelo H Losso
Cardiovascular risk is increased in HIV-infected patients and has become a leading cause of morbi-mortality in this population. The purpose of this study is to compare HIV-infected patients on antiretroviral therapy (ART) and ART-naïve HIV-infected patients regarding arterial elasticity. From September 2010 to September 2015, 105 HIV-infected subjects were enrolled, 41 ART-naïve and 64 on ART with stable viral suppression. Elasticity of large and small arteries (LAE and SAE) was assessed by analysis of radial pulse waveforms using a calibrated device...
2017: Medicina
https://www.readbyqxmd.com/read/28991883/inflammation-related-morbidity-and-mortality-among-hiv-positive-adults-how-extensive-is-it
#20
Brian B Hart, Anna D Nordell, Jason F Okulicz, Adrian Palfreeman, Andrzej Horban, Eynat Kedem, Jacqueline Neuhaus, David R Jacobs, Daniel A Duprez, James D Neaton
OBJECTIVE: To determine the rate of grade 4, potentially life-threatening, events not attributable to AIDS, cardiovascular disease (CVD) or non-AIDS cancer among participants on antiretroviral therapy (ART), and to describe associations of these events with interleukin-6 and D-dimer. DESIGN: Cohort study. METHODS: HIV-infected participants on ART (N=3,568) with an HIV RNA level ≤ 500 copies/mL were followed for grade 4, AIDS, CVD, non-AIDS cancer and all-cause mortality events...
October 4, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
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