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Diabetic Cardiomyopathy

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https://www.readbyqxmd.com/read/29686513/potential-role-of-cyanidin-3-glucoside-c3g-in-diabetic-cardiomyopathy-in-diabetic-rats-an-in-vivo-approach
#1
Weizhen Li, Songwen Chen, Genqing Zhou, Hongli Li, Lan Zhong, Shaowen Liu
The present study aimed to evaluate the importance of cyanidin 3-glucoside (C3G) of diabetic cardiomyopathy in diabetic rats. The rats were induced with diabetic using streptozotocin and total triglyceride (TG) and total cholesterol (TC) were determined. The range of myocardial enzymes such as aspartate aminotransferase (AST), creatine kinase (CK) and lactate dehydrogenase (LD) were also estimated, further, the Immuno histochemical analysis and western blot investigation were determined for the actual activity of C3G...
March 2018: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/29682576/effects-of-pravastatin-on-type-1-diabetic-rat-heart-with-or-without-blood-glycemic-control
#2
Jeong Jin Min, Byung-Seop Shin, Jong-Hwan Lee, Yunseok Jeon, Dae Kyun Ryu, Sojin Kim, Young Hee Shin
Although statins have been suggested to attenuate the progression of diabetic cardiomyopathy, its effect without glycemic control remains unclear. Therefore, we evaluated the effect of pravastatin on diabetic rat hearts according to glycemic control. Rats were randomly divided into five groups: control (C), diabetes (D), diabetes with insulin (I), diabetes with pravastatin (P), and diabetes with insulin and pravastatin (IP). Eight weeks after allocated treatments, the heart was extracted and analyzed following echocardiography...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29677191/type-2-diabetic-aldehyde-dehydrogenase-2-mutant-mice-aldh-2-2-exhibiting-heart-failure-with-preserved-ejection-fraction-phenotype-can-be-determined-by-exercise-stress-echocardiography
#3
Guodong Pan, Srikar Munukutla, Ananya Kar, Joseph Gardinier, Rajarajan A Thandavarayan, Suresh Selvaraj Palaniyandi
E487K point mutation of aldehyde dehydrogenase (ALDH) 2 (ALDH2*2) in East Asians intrinsically lowers ALDH2 activity. ALDH2*2 is associated with diabetic cardiomyopathy. Diabetic patients exhibit heart failure of preserved ejection fraction (HFpEF) i.e. while the systolic heart function is preserved in them, they may exhibit diastolic dysfunction, implying a jeopardized myocardial health. Currently, it is challenging to detect cardiac functional deterioration in diabetic mice. Stress echocardiography (echo) in the clinical set-up is a procedure used to measure cardiac reserve and impaired cardiac function in coronary artery diseases...
2018: PloS One
https://www.readbyqxmd.com/read/29674007/mst1-inhibits-sirt3-expression-and-contributes-to-diabetic-cardiomyopathy-through-inhibiting-parkin-dependent-mitophagy
#4
Shanjie Wang, Zhijing Zhao, Yanhong Fan, Mingming Zhang, Xinyu Feng, Jie Lin, Jianqiang Hu, Zheng Cheng, Chuang Sun, Tingting Liu, Zhenyu Xiong, Zhi Yang, Haichang Wang, Dongdong Sun
Mitochondrial dysfunction contributes to heart failure induced mortality in approximately 80% of diabetic patients. Mitophagy degrades defective mitochondria and maintains a healthy mitochondrial population, which is essential for cardiomyocyte survival in diabetic stress. Herein, we determined whether Mst1 regulated mitophagy and investigated the downstream signaling pathway in the development of diabetic cardiomyopathy (DCM). Mst1 deficiency promoted elimination of dysfunctional mitochondria in diabetic cardiomyopathy without affecting mitochondrial biogenesis...
April 16, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29670886/lncrnas-proverbial-genomic-junk-or-key-epigenetic-regulators-during-cardiac-fibrosis-in-diabetes
#5
Saumik Biswas, Anu Alice Thomas, Subrata Chakrabarti
Long non-coding RNAs (lncRNAs) are critical regulators in a multitude of biological processes. Recent evidences demonstrate potential pathogenetic implications of lncRNAs in diabetic cardiomyopathy (DCM); however, the majority of lncRNAs have not been comprehensively characterized. While the precise molecular mechanisms underlying the functions of lncRNAs remain to be deciphered in DCM, emerging data in other pathophysiological conditions suggests that lncRNAs can have versatile features such as genomic imprinting, acting as guides for certain histone-modifying complexes, serving as scaffolds for specific molecules, or acting as molecular sponges...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29663894/coenzyme-q10-in-cardiovascular-and-metabolic-diseases-current-state-of-the-problem
#6
Vladlena I Zozina, Serghei Covantev, Olga A Goroshko, Liudmila M Krasnykh, Vladimir G Kukes
The burden of cardiovascular and metabolic diseases is increasing with every year. Although the management of these conditions has improved greatly over the years it is still far from perfect. With all of this in mind, there is a need for new methods of prophylaxis and treatment. Coenzyme Q10 (CoQ10) is an essential compound of the human body. There is growing evidence that CoQ10 is tightly linked to cardiometabolic disorders. Its supplementation can be useful in a variety of chronic and acute disorders. This review analyses the role of CoQ10 in hypertension, ischemic heart disease, myocardial infarction, heart failure, viral myocarditis, cardiomyopathies, cardiac toxicity, dyslipidemia, obesity, type 2 diabetes mellitus, metabolic syndrome, cardiac procedures and resuscitation...
April 15, 2018: Current Cardiology Reviews
https://www.readbyqxmd.com/read/29663803/simultaneous-fluorescence-visualization-of-endoplasmic-reticulum-superoxide-anion-and-polarity-in-myocardial-cells-and-tissue
#7
Haibin Xiao, Chuanchen Wu, Ping Li, Bo Tang
Diabetic cardiomyopathy (DCM) is a critical complication of diabetes, the accurate pathogenesis of which remains elusive. It's widely accepted that endoplasmic reticulum (ER) stress and abnormal fluctuations of reactive oxygen species (ROS) are considered to be closely associated with progress of DCM. In addition, DCM-induced changes of myocardial tissue and ROS-derived oxidation of proteins will cause changes of the hydrophilic and hydrophobic domains and may further seriously alter the myocardial cell polarity...
April 17, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29662310/in-vitro-vivo-drug-release-and-anti-diabetic-cardiomyopathy-properties-of-curcumin-pblg-peg-pblg-nanoparticles
#8
Fei Tong, Rongkui Chai, Haiying Jiang, Bo Dong
Background: The objective of this study was to survey the therapeutic function of curcumin-encapsulated poly(gamma-benzyl l-glutamate)-poly(ethylene glycol)-poly(gammabenzyl l-glutamate) (PBLG-PEG-PBLG) (P) on diabetic cardiomyopathy (DCM) via cross regulation effect of calcium-sensing receptor (CaSR) and endogenous cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2 S). Methods: Diabetic rats were preconditioned with 20 mg/kg curcumin or curcumin/P complex continuously for 8 weeks...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29661781/relation-of-aortic-stiffness-to-left-ventricular-remodelling-in-younger-adults-with-type-2-diabetes
#9
Gaurav S Gulsin, Daniel J Swarbrick, William H Hunt, Eylem Levelt, Matthew Pm Graham-Brown, Kelly S Parke, Joanne V Wormleighton, Florence Y Lai, Thomas Yates, Emma G Wilmot, David R Webb, Melanie J Davies, Gerry P McCann
Individuals with type 2 diabetes have a three-to-five-fold increased risk of developing heart failure. Diabetic cardiomyopathy is typified by left ventricular (LV) concentric remodelling, which is a recognised predictor of adverse cardiovascular events. Although the mechanisms underlying LV remodelling in type 2 diabetes are unclear, progressive aortic stiffening may be a key determinant. The aim of this study was to assess the relationship between aortic stiffness and LV geometry in younger adults with type 2 diabetes, using multiparametric cardiovascular magnetic resonance imaging...
April 16, 2018: Diabetes
https://www.readbyqxmd.com/read/29660923/haemochromatosis-pathophysiology-and-the-red-blood-cell1
#10
Kieran J Richardson, Antony P McNamee, Michael J Simmonds
Haemochromatosis remains the most prevalent genetic disorder of Caucasian populations in Australia and the United States, occurring in ∼1 of 200 individuals and having a carrier frequency of 10-14%. Hereditary haemochromatosis is an autosomal recessive condition, that is phenotypically characterised by a gradual accumulation of iron, above and beyond that required for biological function. Once the binding capacity of iron carriers reaches saturation, the highly reactive free iron generates radicals that may lead to widespread cellular dysfunction...
April 7, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29659778/impact-of-diabetes-mellitus-on-the-contractile-properties-of-the-left-and-right-atrial-myofilaments
#11
Constanze Bening, Khaled Alhussini, Elena-Aura Mazalu, Jonathan Yaqub, Khaled Hamouda, Dejan Radakovic, Christoph Schimmer, Grzegorz Hirnle, Rainer Leyh
OBJECTIVES: The incidence of diabetes mellitus in patients with ischaemic cardiomyopathy is increasing. To evaluate the impact of diabetes mellitus on contractility, we examined the calcium-induced force in left and right atrial myofilaments of patients with and without diabetes. METHODS: We included 149 patients (106 without diabetes, 43 with diabetes), scheduled for elective coronary artery bypass grafting from August 2016 to June 2017. The left and right atria were excised and prepared for skinned fibre measurements (pCa-force curve)...
April 12, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29659121/glucagon-like-peptide-1-ameliorates-cardiac-lipotoxicity-in-diabetic-cardiomyopathy-via-the-ppar%C3%AE-pathway
#12
Lujin Wu, Ke Wang, Wei Wang, Zheng Wen, Peihua Wang, Lei Liu, Dao Wen Wang
Lipotoxicity cardiomyopathy is the result of excessive accumulation and oxidation of toxic lipids in the heart. It is a major threat to patients with diabetes. Glucagon-like peptide-1 (GLP-1) has aroused considerable interest as a novel therapeutic target for diabetes mellitus because it stimulates insulin secretion. Here, we investigated the effects and mechanisms of the GLP-1 analog exendin-4 and the dipeptidyl peptidase-4 inhibitor saxagliptin on cardiac lipid metabolism in diabetic mice (DM). The increased myocardial lipid accumulation, oxidative stress, apoptosis, and cardiac remodeling and dysfunction induced in DM by low streptozotocin doses and high-fat diets were significantly reversed by exendin-4 and saxagliptin treatments for 8 weeks...
April 16, 2018: Aging Cell
https://www.readbyqxmd.com/read/29643979/cardiac-autonomic-neuropathy-as-a-result-of-mild-hypercaloric-challenge-in-absence-of-signs-of-diabetes-modulation-by-antidiabetic-drugs
#13
Ola Al-Assi, Rana Ghali, Ali Mroueh, Abdullah Kaplan, Nahed Mougharbil, Ali H Eid, Fouad A Zouein, Ahmed F El-Yazbi
Cardiac autonomic neuropathy (CAN) is an early cardiovascular complication of diabetes occurring before metabolic derangement is evident. The cause of CAN remains elusive and cannot be directly linked to hyperglycemia. Recent clinical data report cardioprotective effects of some antidiabetic drugs independent of their hypoglycemic action. Here, we used a rat model receiving limited daily increase in calories from fat (HC diet) to assess whether mild metabolic challenge led to CAN in absence of interfering effects of hyperglycemia, glucose intolerance, or obesity...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29627764/dynamic-role-of-the-transmembrane-glycoprotein-cd36-sr-b2-in-cellular-fatty-acid-uptake-and-utilization
#14
Jan F C Glatz, Joost J F P Luiken
The widely expressed transmembrane glycoprotein CD36, a scavenger receptor class B protein (SR-B2), serves many functions in lipid metabolism and signaling. Here, we review CD36's role in facilitating cellular long-chain fatty-acid uptake across the plasma membrane, particularly in heart and skeletal muscles. CD36 acts in concert with other membrane proteins, such as peripheral plasma membrane fatty acid-binding protein (FABPpm), and is an intracellular docking site for cytoplasmic FABP (FABPc). The cellular fatty-acid uptake rate is governed primarily by the presence of CD36 at the cell surface, which is regulated by the subcellular vesicular recycling of CD36 from endosomes to the plasma membrane...
April 7, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29627307/abnormal-myocardial-dietary-fatty-acid-metabolism-and-diabetic-cardiomyopathy
#15
REVIEW
André C Carpentier
Patients with diabetes are at very high risk of hospitalization and death from heart failure. Increased prevalence of coronary heart disease, hypertension, autonomic neuropathy, and kidney failure all play a role in this increased risk. However, cardiac metabolic abnormalities are now recognized to play a role in this increased risk. Increased reliance on fatty acids to produce energy might predispose the diabetic heart to oxidative stress and ischemic damage. Intramyocellular accumulation of toxic lipid metabolites leads to a number of cellular abnormalities that might also contribute to cardiac remodelling and cardiac dysfunction...
January 16, 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29626099/incidence-risk-factors-and-clinical-characteristics-of-peripartum-cardiomyopathy-in-south-korea
#16
Sunki Lee, Geum Joon Cho, Geun U Park, Log Young Kim, Tae-Seon Lee, Do Young Kim, Suk-Won Choi, Jong-Chan Youn, Seong Woo Han, Kyu-Hyung Ryu, Jin Oh Na, Cheol Ung Choi, Hong Seog Seo, Eung Ju Kim
BACKGROUND: Peripartum cardiomyopathy (PPCM) is a rare disorder associated with pregnancy that can lead to life-threatening conditions. The incidence and clinical characteristics of this condition remain poorly understood. METHODS AND RESULTS: We aimed to perform the first population-based study of PPCM in South Korea, using the Korea National Health Insurance Claims Database of the Health Insurance Review and Assessment Service. Patients who fulfilled predefined diagnostic criteria for PPCM from January 1, 2010, to December 31, 2012, were identified from International Classification of Diseases, Tenth Revision, Clinical Modification codes...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29625944/prophylactic-mechanisms-of-cucumis-melo-var-flexuosus-and-phoenix-dactylifera-fruit-extracts-against-diabetic-cardiomyopathy-in-streptozotocin-induced-diabetic-rats
#17
Amna Ali Saddi, Azza Mostafa Mohamed, Abdulkader Mohamed Shaikh
The aim of this investigation was to study the antidiabetic impact of Cucumis melo var. flexuosus and/or Phoenix dactylifera fruit aqueous extracts and their mechanisms in repressing diabetes induced cardio-myopathy in diabetic rats. Type 2 diabetes was promoted in rats by a single intraperitoneal injection of streptozotocin (30mg/kg body wight). C. flexuosus and P. dactylifera extracts (200mg/kg body weight, each) were ingested to diabetic rats daily for a month. The results showed that ingestion of either plant extract or their combination to diabetic rats significantly diminished the glucose level and boosted the insulin concentration in the blood...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29625179/proteostasis-in-epicardial-versus-subcutaneous-adipose-tissue-in-heart-failure-subjects-with-and-without-diabetes
#18
A Burgeiro, A C Fonseca, D Espinoza, L Carvalho, N Lourenço, M Antunes, E Carvalho
BACKGROUND: Cardiovascular diseases (CVDs) are leading cause of death and primary cause of morbidity and mortality in diabetic population. Epicardial adipose tissue (EAT) covers the heart's surface and is a source of biomolecules regulating heart and blood vessel physiology. The protective activation of the unfolded protein response (UPR) and autophagy allows the cardiomyocyte reticular network to restore energy and/or nutrient homeostasis and to avoid cell death. However, an excessive or prolonged UPR activation can trigger cell death...
April 3, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29607874/astraglaus-polysaccharide-protects-diabetic-cardiomyopathy-by-activating-nrg1-erbb-pathway
#19
Xiao Chang, Kang Lu, Ling Wang, Min Lv, Wenjun Fu
Diabetic cardiomyopathy (DCM) is one of the main cardiac complications among diabetic patients. According to previous studies, the pathogenesis of DCM is associated with oxidative stress, apoptosis and proliferation of local cardiac cells. It showed, NRG1 can improve the function of mitochondria, and thereby, increasing proliferation and decreasing apoptosis of cardiac muscle cell via ErbB/AKT signaling, also, exert antioxidative function. Besides, NRG1/ErbB pathway was impaired in the DCM model which suggested this signaling played key role in DCM...
April 2, 2018: Bioscience Trends
https://www.readbyqxmd.com/read/29607187/the-present-and-future-role-of-ultrasound-targeted-microbubble-destruction-in-preclinical-studies-of-cardiac-gene-therapy
#20
REVIEW
Lijun Qian, Barsha Thapa, Jian Hong, Yanmei Zhang, Menglin Zhu, Ming Chu, Jing Yao, Di Xu
Multiple limitations for cardiac pharmacologic therapies like intolerance, individual variation in effectiveness, side effects, and high cost still remain, despite the recent progress in diagnosis and health support. Gene therapy is poised to be an attractive alternative in various ways for the future, refractory cardiac diseases being one aspect of it. As a novel therapy to deliver the objective gene to organs of living animals, ultrasound targeted microbubble destruction (UTMD) has therapeutic potential in cardiovascular disorders...
February 2018: Journal of Thoracic Disease
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