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Diabetic Cardiomyopathy

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https://www.readbyqxmd.com/read/29912308/metabolic-changes-in-hypertrophic-cardiomyopathies-scientific-update-from-the-working-group-of-myocardial-function-of-the-european-society-of-cardiology
#1
Jolanda van der Velden, Carlo Gabriele Tocchetti, Gilda Varricchi, Anna Bianco, Vasco Sequeira, Denise Hilfiker-Kleiner, Nazha Hamdani, Adelino Leite-Moreira, Manuel Mayr, Ines Falcão-Pires, Thomas Thum, Dana K Dawson, Jean-Luc Balligand, Stephane Heymans
Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the CVR spotlight issue on Metabolic cardiomyopathies).1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Here, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy (HCM) and discuss several therapies which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy...
June 15, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29909009/knockout-of-cnr1-prevents-metabolic-stress-induced-cardiac-injury-through-improving-insulin-resistance-ir-injury-and-endoplasmic-reticulum-er-stress-by-promoting-ampk-alpha-activation
#2
Su-Juan Pei, Huai-Yuan Zhu, Jin-Hui Guo, Xin Zhang, Zhi-Jian Deng
Obesity and diabetes are associated with diabetic cardiomyopathy (DCM). However, the pathogenesis of DCM is not fully understood. Cannabinoid receptor gene (CNR1) has been a drug target for the treatment of obesity. Here, we reported that CNR1 expression was increased in high fat diet (HFD)-induced heart of mice. Following, the wild type (CNR1+/+ ) and CNR1-knockout (CNR1-/- ) mice were employed and subjected to HFD treatments for 16 weeks to further investigate the effects of CNR1 on DCM. The results indicated that CNR1 knockout mice after HFD feeding exhibited a significant decrease of body weight and lipid accumulation in serum...
June 14, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29894997/metabolic-syndrome-in-hyperprolactinemia
#3
Marianne Andersen, Dorte Glintborg
The metabolic syndrome (MetS) is a conglomerate of clinical findings that convey into increased morbidity and mortality from type 2 diabetes mellitus (T2D) and cardiovascular disease. Hyperprolactinemia (hyperPRL) is associated with components of MetS, especially during pregnancy. Endogenous levels of sex steroids are high during pregnancy in contrast to untreated or replaced hypogonadism in most patients with a prolactinoma and hypogonadism may confer increased risk of MetS in hyperPRL. Dopamine-D2-agonist therapy can improve MetS in patients with a prolactinoma and lower glucose levels in patients with T2D...
2018: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/29894781/glycophagy-an-emerging-target-in-pathology
#4
REVIEW
Hong Zhao, Mingzhu Tang, Meiqing Liu, Linxi Chen
Autophagy, a highly conserved self-digestion process, is initially regarded as non-selectively sequestering and degradation cytoplasmic contents. Nowadays, many kinds of selective autophagy have been found in response to various physiological cues such as mitophagy, reticulophagy and glycophagy. Glycophagy, as a selective autophagy, plays a crucial role in maintaining glucose homeostasis in many tissues including heart, liver and skeletal muscles. Moreover, glycophagy is highly regulated by many signal pathways like the cyclic AMP protein kinase A/protein kinase A, PI3K-Akt/PKB-mTOR and Calcium...
June 9, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29891446/-exendin-4-alleviates-diabetic-cardiomyopathy-in-mice-by-regulating-sirt1-pgc1%C3%AE
#5
Ying-Ying Cai, Shao-Zhou Zou, Cun-Xia Fan, Chun-Yan Wu, Shu Fang, Ping Li, Yao-Ming Xue, Mei-Ping Guan
OBJECTIVE: To investigate the protective effect of exendin-4 against diabetic cardiomyopathy in mice and explore the underlying mechanism. METHODS: C57BL/6J mice were randomly divided into normal control group with normal diet and diabetic group with high-fat diet for 4 weeks before streptozotocin injection. The successfully established diabetic mouse models were divided into diabetic group with exendin-4 treatment and diabetic control group for daily treatment with intraperitoneal injection of 1 nmol/kg exendin-4 and saline of equivalent volume for 8 weeks, respectively...
May 20, 2018: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/29884823/microrna-410-5p-exacerbates-high-fat-diet-induced-cardiac-remodeling-in-mice-in-an-endocrine-fashion
#6
Tong Zou, Mei Zhu, Yi-Cheng Ma, Fei Xiao, Xue Yu, Li Xu, Lan-Qing Ma, Jiefu Yang, Jian-Zeng Dong
Metabolic disorders, such as obesity and type 2 diabetes, are associated with an increased risk of cardiomyopathy. To date, microRNA (miRNAs) functions in cardiac remodeling induced by obesity remain to be elucidated. We found that rats fed a high fat diet (HFD) manifested cardiac fibrosis and LV dysfunction. In the heart of rats fed HFD, the phosphorylation levels of Smad 2 and the expression of fibrotic genes, such as connective tissue growth factor, collagen-1α1 (Col1α1), Col3α1, and Col4α1, were up-regulated, which accompanied by an increase in Smad 7 protein levels, but not its mRNA levels...
June 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29880742/a-crude-1-dnj-extract-from-home-made-bombyx-batryticatus-inhibits-diabetic-cardiomyopathy-associated-fibrosis-in-db-db-mice-and-reduces-protein-n-glycosylation-levels
#7
Qing Zhao, Tian Zhu Jia, Qi Chen Cao, Fang Tian, Wan Tao Ying
The traditional Chinese drug Bombyx Batryticatus (BB), which is also named the white stiff silkworm, has been widely used in Chinese clinics for thousands of years. It is famous for its antispasmodic and blood circulation-promoting effects. Cardiomyocyte hypertrophy, interstitial cell hyperplasia, and myocardial fibrosis are closely related to the N -glycosylation of key proteins. To examine the alterations of N -glycosylation that occur in diabetic myocardium during the early stage of the disease, and to clarify the therapeutic effect of 1-Deoxynojirimycin (1-DNJ) extracted from BB, we used the db/db (diabetic) mouse model and an approach based on hydrophilic chromatography solid-phase extraction integrated with an liquid Chromatograph Mass Spectrometer (LC-MS) identification strategy to perform a site-specific N -glycosylation analysis of left ventricular cardiomyocyte proteins...
June 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29874110/copper-transporters-and-copper-chaperones-roles-in-cardiovascular-physiology-and-disease
#8
Tohru Fukai, Masuko Ushio-Fukai, Jack H Kaplan
Copper (Cu) is an essential micronutrient but excess Cu is potentially toxic. Its important propensity to cycle between two oxidation states accounts for its frequent presence as a co-factor in many physiological processes through Cu-containing enzymes, including mitochondrial energy production (via cytochrome c oxidase), protection against oxidative stress (via superoxide dismutase), and extracellular matrix stability (via lysyl oxidase). Since free Cu is potentially toxic, the bioavailability of intracellular Cu is tightly controlled by Cu transporters and Cu chaperones...
June 6, 2018: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/29867479/curcumin-a-polyphenolic-curcuminoid-with-its-protective-effects-and-molecular-mechanisms-in-diabetes-and-diabetic-cardiomyopathy
#9
REVIEW
Jia Zheng, Jing Cheng, Sheng Zheng, Qianyun Feng, Xinhua Xiao
As the leading cause of morbidity and mortality in patients with diabetes, diabetic cardiomyopathy (DCM) imposes enormous burden on individuals and public health. Therapeutic regimes for DCM treatment have proven to be challenging, with limited efficacy, low compliance, and potential adverse effects. Curcumin, as the most active compound derived from the root of turmeric, exhibits strong anti-inflammation, antioxidant, and anti-apoptosis properties. Recently, clinical trials and preclinical studies have shown that curcumin exerts protective effects against a variety of diseases, including diabetes and its cardiovascular complications...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29867137/vascular-endothelial-dysfunction-a-major-mediator-in-diabetic-cardiomyopathy
#10
REVIEW
Maura Knapp, Xin Tu, Rongxue Wu
Diabetes mellitus is currently a major public health problem. A common complication of diabetes is cardiac dysfunction, which is recognized as a microvascular disease that leads to morbidity and mortality in diabetic patients. While ischemic events are commonly observed in diabetic patients, the risk for developing heart failure is also increased, independent of the severity of coronary artery disease and hypertension. This diabetes-associated clinical entity is considered a distinct disease process referred to as "diabetic cardiomyopathy"...
June 4, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29858985/predisposing-factors-to-heart-failure-in-diabetic-nephropathy-a-look-at-the-sympathetic-nervous-system-hyperactivity
#11
REVIEW
Klara Komici, Grazia Daniela Femminella, Claudio de Lucia, Alessandro Cannavo, Leonardo Bencivenga, Graziamaria Corbi, Dario Leosco, Nicola Ferrara, Giuseppe Rengo
Diabetes mellitus (DM) and heart failure (HF) are frequent comorbidities among elderly patients. HF, a leading cause of mortality and morbidity worldwide, is characterized by sympathetic nervous system hyperactivity. The prevalence of diabetes mellitus (DM) is rapidly growing and the risk of developing HF is higher among DM patients. DM is responsible for several macro- and micro-angiopathies that contribute to the development of coronary artery disease (CAD), peripheral artery disease, retinopathy, neuropathy and diabetic nephropathy (DN) as well...
June 1, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29858880/fragmentation-of-qrs-complex-during-ventricular-pacing-is-associated-with-ventricular-arrhythmic-events-in-patients-with-left-ventricular-dysfunction
#12
Freddy Del-Carpio Munoz, Peter A Noseworthy, S Michael Gharacholou, Christopher G Scott, Vuyisile T Nkomo, Francisco Lopez-Jimenez, Yong-Mei Cha, Thomas M Munger, Paul A Friedman, Samuel J Asirvatham
BACKGROUND: QRS fragmentation (fQRS) during baseline ventricular conduction, a myocardial fibrosis marker, is associated with increased risk of ventricular tachyarrhythmias but may not manifest unless ventricular activation change is provoked. We examined the association of fQRS during right ventricular (RV) pacing with death and ventricular tachyarrhythmia in patients with left ventricular (LV) dysfunction undergoing electrophysiology study (EPS). METHODS AND RESULTS: Study participants had LV dysfunction (ejection fraction < 50%) undergoing EPS from January 2002 through May 2014 at Mayo Clinic in Rochester, Minnesota...
June 2, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29858549/ischemic-versus-non-ischemic-neurogenic-myocardial-contractility-impairment-in-acute-coronary-syndromes-prevalence-and-impact-on-left-ventricular-systolic-function-recovery
#13
Paweł Iwaszczuk, Bartosz Kołodziejczyk, Tomasz Kruczek, Leszek Drabik, Wojciech Płazak, Monika Komar, Piotr Podolec, Piotr Musiałek
BACKGROUND Neurogenic mechanism is believed to contribute to left ventricular (LV) systolic dysfunction in acute coronary syndromes (ACS); its extreme form is known as takotsubo cardiomyopathy. However, the magnitude of neurogenic contribution to LV dysfunction in all-comer first-time ACS remains unknown. MATERIAL AND METHODS In 120 consecutive patients with first-time ACS (age 66.3±12.3years, 40 women) coronary angiograms were individually matched to the echocardiographic left ventricular (LV) segments (17-segment model)...
June 2, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29850631/nlrp3-a-novel-mediator-in-cardiovascular-disease
#14
REVIEW
Wenyi Zhou, Chunyuan Chen, Zhiheng Chen, Lin Liu, Jie Jiang, Zhixiang Wu, Mingyi Zhao, Yanfang Chen
Cardiovascular disease is a major cause of death worldwide. Inflammasome infiltration has been identified to play a central role in the pathological progression of certain cardiovascular diseases, such as vascular damage spanning atherosclerosis, aneurysm, or arteritis; ischemic heart disease; and other nonischemic heart diseases including diabetic cardiomyopathy, chronic heart failure, and hypertension- or virus-induced cardiac dysfunction. The NLRP3 inflammasome, a key participant in the innate immune response, requires both priming and activation signals for the initiation of inflammation...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29849901/exendin-4-and-liraglutide-attenuate-glucose-toxicity-induced-cardiac-injury-through-mtor-ulk1-dependent-autophagy
#15
Wei Yu, Wenliang Zha, Jun Ren
Mitochondrial injury and defective autophagy are common in diabetic cardiomyopathy. Recent evidence supports benefits of glucagon-like peptide-1 (GLP-1) agonists exendin-4 (Exe) and liraglutide (LIRA) against diabetic cardiomyopathy. This study was designed to examine the effect of Exe and LIRA on glucose-induced cardiomyocyte and mitochondrial injury, oxidative stress, apoptosis, and autophagy change. Cardiomyocytes isolated from adult mice and H9c2 myoblast cells were exposed to high glucose (HG, 33 mM) with or without Exe or LIRA...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29843384/alcoholism-a-multi-systemic-cellular-insult-to-organs
#16
REVIEW
Ucee Dguzeh, Natasha C Haddad, Kathia T S Smith, John O Johnson, Angelia A Doye, Judith K Gwathmey, Georges E Haddad
Alcohol abuse can affect more than the heart and the liver. Many observers often do not appreciate the complex and differing aspects of alcohol's effects in pathophysiologies that have been reported in multiple organs. Chronic alcohol abuse is known to be associated with pathophysiological changes that often result in life-threatening clinical outcomes, e.g., breast and colon cancer, pancreatic disease, cirrhosis of the liver, diabetes, osteoporosis, arthritis, kidney disease, immune system dysfunction, hypertension, coronary artery disease, cardiomyopathy, and can be as far-reaching as to cause central nervous system disorders...
May 28, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29782963/bet-inhibition-by-jq1-alleviates-streptozotocin-induced-diabetic-cardiomyopathy
#17
Miao Guo, Hong-Xia Wang, Wen-Jun Chen
Diabetic cardiomyopathy is a cascade of complex events leading to eventual heart failure in diabetes. JQ1, one of Bromodomain and extra-terminal domain (BET) protein inhibitors, has exerted therapeutic effects on cancer proliferation, inflammation and cardiovascular disease. Recently, JQ1 was reported to protect mice from bleomycin-induced lung fibrosis and reverse the fibrotic response in carbon tetrachloride-induced liver fibrosis. However, its role in diabetic cardiomyopathy remains to be clarified. Our results indicated that JQ1 treatment suppressed cardiac fibrosis and improved cardiac function in a STZ-induced diabetic mouse model...
May 18, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29778538/naringenin-exhibits-the-protective-effect-on-cardiac-hypertrophy-via-eets-ppars-activation-in-streptozocin-induced-diabetic-mice
#18
Jie Zhang, Hongmei Qiu, Jiajun Huang, Shumei Ding, Bo Huang, Qin Wu, Qingsong Jiang
Cardiac hypertrophy is one of the key structural changes in diabetic cardiomyopathy. Naringenin, a dihydroflavonoid extracted from citrus plants with multiple pharmacological activities, yet the underlying effects on diabetic cardiac hypertrophy remain unclear. This study aimed to evaluate the potential effects of naringenin on cardiac hypertrophy in diabetic mice. Long-term high-fat feeding combined with streptozotocin resulted in cardiac hypertrophy after a diabetic model has been established for 4 weeks in mice, which were improved by naringenin supplementation (25 or 75 mg/kg/day, i...
May 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29778534/fibroblast-growth-factor-19-protects-the-heart-from-oxidative-stress-induced-diabetic-cardiomyopathy-via-activation-of-ampk-nrf2-ho-1-pathway
#19
Xin Li, Di Wu, Ye Tian
Diabetes affects cardiac structure and function, where it leads to diabetic cardiomyopathy. Reactive oxygen species (ROS) produced by oxidative stress play an important role in the development of diabetic cardiomyopathy. Fibroblast growth factor (FGF) 19, an enterokine, is synthesized and released into the ileum. In the present study, we revealed that FGF19 induced an antioxidant response through stimulating the expression of nuclear erythroid factor 2 (NE-F2)-related factor 2 (Nrf2) and as well as reducing ROS production through the AMPK signaling pathway...
May 23, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29774216/autophagic-regulation-of-lipid-homeostasis-in-cardiometabolic-syndrome
#20
Mingjie Yang, Yingmei Zhang, Jun Ren
As an important protein quality control process, autophagy is essential for the degradation and removal of long-lived or injured cellular components and organelles. Autophagy is known to participate in a number of pathophysiological processes including cardiometabolic syndrome. Recent findings have shown compelling evidence for the intricate interplay between autophagy and lipid metabolism. Autophagy serves as a major regulator of lipid homeostasis while lipid can also influence autophagosome formation and autophagic signaling...
2018: Frontiers in Cardiovascular Medicine
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