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Diabetic Cardiomyopathy

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https://www.readbyqxmd.com/read/28822817/rosiglitazone-promotes-cardiac-hypertrophy-and-alters-chromatin-remodeling-in-isolated-cardiomyocytes
#1
Lama Fawaz Pharaon, Naglaa Fathi El-Orabi, Muhammad Kunhi, Nadya Al Yacoub, Salma Mahmoud Awad, Coralie Poizat
Rosiglitazone is an anti-diabetic agent that raised a major controversy over its cardiovascular adverse effects. There is in vivo evidence that Rosiglitazone promotes cardiac hypertrophy by PPAR -γ-independent mechanisms. However, whether Rosiglitazone directly alters hypertrophic growth in cardiac cells is unknown. Chromatin remodeling by histone post-translational modifications has emerged as critical for many cardiomyopathies. Based on these observations, this study was initiated to investigate the cardiac hypertrophic effect of Rosiglitazone in a cellular model of primary neonatal rat cardiomyocytes (NRCM)...
August 16, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28818204/geometry-as-a-confounder-when-assessing-ventricular-systolic-function-comparison-between-ejection-fraction-and-strain
#2
Thomas M Stokke, Nina E Hasselberg, Marit K Smedsrud, Sebastian I Sarvari, Kristina H Haugaa, Otto A Smiseth, Thor Edvardsen, Espen W Remme
BACKGROUND: Preserved left ventricular (LV) ejection fraction (EF) and reduced myocardial strain are reported in patients with hypertrophic cardiomyopathy, ischemic heart disease, diabetes mellitus, and more. OBJECTIVES: The authors performed a combined mathematical and echocardiographic study to understand the inconsistencies between EF and strains. METHODS: An analytical equation showing the relationship between EF and the 4 parameters, global longitudinal strain (GLS), global circumferential strain (GCS), wall thickness, and short-axis diameter, was derived from an elliptical LV model...
August 22, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28803513/mechanisms-of-unexpected-death-and-autopsy-findings-in-friedreich-ataxia
#3
Roger W Byard, John D Gilbert
A 36-year-old woman with a clinical history of Friedreich ataxia and hypertrophic cardiomyopathy was found unexpectedly dead at her home. The heart showed asymmetric left ventricular hypertrophy, with an interventricular septal thickness of 20-25 mm (the remainder of the left ventricular wall measured 15 mm). Histologically, both ventricles had irregular areas of marked myocyte hypertrophy with associated interstitial fibrosis and focal myofibre disarray. There was neuronal loss within the dentate nucleus of the cerebellum, with vacuolation and axonal loss in the dorsal columns and spinocerebellar tracts of the upper cervical spinal cord...
January 1, 2017: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/28801532/activation-of-nkx2-5-calr-p53-signaling-pathway-by-hyperglycemia-induces-cardiac-remodeling-and-dysfunction-in-adult-zebrafish
#4
Sun Yanyi, Wang Qiuyun, Fang Yuehua, Wu Chunfang, Lu Guoping, Chen Zhenyue
Hyperglycemia is an independent risk factor for diabetic cardiomyopathy in humans; however, the underlying mechanisms have not been thoroughly elucidated. Zebrafish (Danio rerio) was used in this study as a novel vertebrate model to explore the signaling pathways of human adult cardiomyopathy. Hyperglycemia was induced by alternately immersing adult zebrafish in a glucose solution or water. The hyperglycemic fish gradually exhibited some hallmarks of cardiomyopathy such as myocardial hypertrophy and apoptosis, myofibril loss, fetal gene reactivation, and severe arrhythmia...
August 11, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28801525/exercise-of-obese-mice-induces-cardioprotection-and-oxygen-sparing-in-hearts-exposed-to-high-fat-load
#5
Neoma T Boardman, Anne Dragøy Hafstad, Jim Lund, Line Rossvoll, Ellen Aasum
Exercise training is a potent, therapeutic approach in obesity and diabetes that exerts protective effects against development of diabetic cardiomyopathy and ischemic-injury. Acute increases in circulating fatty acids (FAs) during an ischemic insult can challenge the heart, as high FA-load is considered to have adverse cardiac effects. In the present study, we tested the hypothesis that exercise-induced cardiac effects in diet-induced obese mice are abrogated by an acute high FA-load. Diet-induced obese mice were fed a high-fat diet (HFD) for 20 weeks...
August 11, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28796243/exogenous-h2s-facilitating-ubiquitin-aggregates-clearance-via-autophagy-attenuates-type-2-diabetes-induced-cardiomyopathy
#6
Jichao Wu, Zhiliang Tian, Yu Sun, Cuicui Lu, Ning Liu, Zhaopeng Gao, Linxue Zhang, Shiyun Dong, Fan Yang, Xin Zhong, Changqing Xu, Fanghao Lu, Weihua Zhang
Diabetic cardiomyopathy (DCM) is a serious complication of diabetes. Hydrogen sulphide (H2S), a newly found gaseous signalling molecule, has an important role in many regulatory functions. The purpose of this study is to investigate the effects of exogenous H2S on autophagy and its possible mechanism in DCM induced by type II diabetes (T2DCM). In this study, we found that sodium hydrosulphide (NaHS) attenuated the augment in left ventricular (LV) mass and increased LV volume, decreased reactive oxygen species (ROS) production and ameliorated H2S production in the hearts of db/db mice...
August 10, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28791311/assessment-of-diabetic-cardiomyopathy-by-cardiovascular-magnetic-resonance-t1-mapping-correlation-with-left-ventricular-diastolic-dysfunction-and-diabetic-duration
#7
Yongning Shang, Xiaochun Zhang, Weilling Leng, Liu Chen, Xiaotian Lei, Tianjing Zhang, Andreas Greiser, Ziwen Liang, Jian Wang
PURPOSE: To quantify extracellular matrix expansion with the cardiovascular magnetic resonance (CMR) T1 mapping technique and the derived extracellular volume fraction (ECV) in diabetic cardiomyopathy (DbCM) patients and to detect the relationship among ECV, duration of diabetes, and diastolic function. MATERIALS: Thirty-eight patients with diabetic cardiomyopathy (20 males, age 54.6 ± 8.6 years) and thirty-two matched normal controls (15 males, age 51.4 ± 13...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28790925/nlrp3-inflammasome-as-a-molecular-marker-in-diabetic-cardiomyopathy
#8
REVIEW
Beibei Luo, Feng Huang, Yanli Liu, Yiying Liang, Zhe Wei, Honghong Ke, Zhiyu Zeng, Weiqiang Huang, Yan He
Diabetic cardiomyopathy (DCM), a common consequence of longstanding diabetes mellitus, is initiated by death of cardiomyocyte. Hyperglycemia-induced reactive oxygen species (ROS) overproduction is a major contributor of the chronic low-grade inflammation that characterizes as the DCM. ROS may promote the activation of nucleotide-binding oligomerization domain like receptor (NLR) pyrin domain containing 3 (NLRP3) inflammasome, a novel regulator of inflammation and cell death, by nuclear factor-kB (NF-κB) and thioredoxin interacting/inhibiting protein (TXNIP)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28789938/azilsartan-ameliorates-diabetic-cardiomyopathy-in-young-db-db-mice-through-the-modulation-of-ace-2-ang-1-7-mas-receptor-cascade
#9
Vijayakumar Sukumaran, Hirotsugu Tsuchimochi, Eisuke Tatsumi, Mikiyasu Shirai, James T Pearson
Hyperglycemia up-regulates intracellular angiotensin II (ANG-II) production in cardiac myocytes. This study investigated the hemodynamic and metabolic effects of azilsartan (AZL) treatment in a mouse model of diabetic cardiomyopathy and whether the cardioprotective effects of AZL are mediated by the angiotensin converting enzyme (ACE)-2/ANG 1-7/Mas receptor (R) cascade. Control db/+ and db/db mice (n=5 per group) were treated with vehicle or AZL (1 or 3mg/kg/d oral gavage) from the age of 8 to 16weeks. Echocardiography was then performed and myocardial protein levels of ACE-2, Mas R, AT1R, AT2R, osteopontin, connective tissue growth factor (CTGF), atrial natriuretic peptide (ANP) and nitrotyrosine were measured by Western blotting...
August 5, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28781721/the-effects-of-diabetes-induction-on-the-rat-heart-differences-in-oxidative-stress-inflammatory-cells-and-fibrosis-between-subendocardial-and-interstitial-myocardial-areas
#10
Maria C Guido, Alyne F Marques, Elaine R Tavares, Marcelo D Tavares de Melo, Vera M C Salemi, Raul C Maranhão
Diabetic cardiomyopathy (DCM) is characterized by cardiac remodeling and impaired diastolic function that may lead to heart failure. The aim of this study was to evaluate oxidative stress, inflammatory cells, and fibrosis in both subendocardial (SEN) and interstitial (INT) areas of the myocardium. Male Wistar rats were allocated to 2 groups of 9 animals, a control (CT) group and streptozotocin-induced diabetes (DM). After 8 weeks, echocardiography morphometry, protein expression, and confocal microscopy in SEN and INT areas of the left ventricle (LV) were performed...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28781146/the-impact-of-foxo-1-to-cardiac-pathology-in-diabetes-mellitus-and-diabetes-related-metabolic-abnormalities
#11
Dimitry A Chistiakov, Alexander N Orekhov, Yuri V Bobryshev
Diabetic heart pathology has a serious social impact due to high prevalence worldwide and significant mortality/invalidation of diabetic patients suffered from cardiomyopathy. The pathogenesis of diabetic and diabetes-related cardiomyopathy is associated with progressive loss and impairment of cardiac function due to adverse effects of metabolic, prooxidant, proinflammatory, and pro-apoptotic stress factors. In the adult heart, the transcriptional factor forkhead box-1 (FOXO-1) is involved in maintaining cardiomyocytes in the homeostatic state and induction of their adaptation to metabolic and pro-oxidant stress stimuli...
August 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28776188/alterations-of-relaxin-and-its-receptor-system-components-in-experimental-diabetic-cardiomyopathy-rats
#12
Xiaohui Zhang, Liya Pan, Kelaier Yang, Yu Fu, Yue Liu, Wenjia Chen, Xiao Ma, Xinhua Yin
High glucose induces apoptosis of cardiomyocytes and fibrosis of cardiac fibroblasts, contributing to diabetic cardiomyopathy. In this work, we explore the production of relaxin alterations and the significance of their receptor system components in the hearts of experimental diabetic cardiomyopathy rats. We measured rat relaxin-1 (equivalent to human relaxin-2), relaxin-3, RXFP1 and RXFP3 mRNA expression in the hearts of experimental diabetic cardiomyopathy rats. Neonatal rat ventricular myocytes (NRVMs) and cardiac fibroblasts were treated with 5...
August 3, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28776083/diabetic-cardiomyopathy-a-hyperglycaemia-and-insulin-resistance-induced-heart-disease
#13
REVIEW
Guanghong Jia, Adam Whaley-Connell, James R Sowers
Diabetic cardiomyopathy is characterised in its early stages by diastolic relaxation abnormalities and later by clinical heart failure in the absence of dyslipidaemia, hypertension and coronary artery disease. Insulin resistance, hyperinsulinaemia and hyperglycaemia are each independent risk factors for the development of diabetic cardiomyopathy. The pathophysiological factors in diabetes that drive the development of cardiomyopathy include systemic metabolic disorders, inappropriate activation of the renin-angiotensin-aldosterone system, subcellular component abnormalities, oxidative stress, inflammation and dysfunctional immune modulation...
August 3, 2017: Diabetologia
https://www.readbyqxmd.com/read/28772214/epigallocatechin-3-gallate-protects-against-diabetic-cardiomyopathy-through-modulating-the-cardiometabolic-risk-factors-oxidative-stress-inflammation-cell-death-and-fibrosis-in-streptozotocin-nicotinamide-induced-diabetic-rats
#14
Azza I Othman, Mamdouh R El-Sawi, Mohamed A El-Missiry, Mohammad H Abukhalil
The potential protective effect of epigallocatechin-3-gallate (EGCG) on type 2 diabetes-induced heart injury was investigated. A rat model of diabetes was achieved by injection of nicotinamide (100mg/kg, i.p), 20min before the administration of streptozotocin (55mg/kg, i.p.). After confirmation of diabetes, EGCG (2mg/kg, p.o.) was administrated on alternate days for one month. Treatment of diabetic rats with EGCG showed a remarkable reduction in glucose, glycosylated hemoglobin, HOMA-IR and lipid profile levels with an elevation in insulin levels, indicating its antihyperglycemic and antidyslipidemic actions...
July 31, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28770830/resveratrol-alleviates-diabetic-cardiomyopathy-in-rats-by-improving-mitochondrial-function-through-pgc-1%C3%AE-deacetylation
#15
Wei-Jin Fang, Chun-Jiang Wang, Yang He, Yu-Lu Zhou, Xiang-Dong Peng, Shi-Kun Liu
Recent evidence shows that resveratrol (RSV) may ameliorate high-glucose-induced cardiac oxidative stress, mitochondrial dysfunction and myocardial fibrosis in diabetes. However, the mechanisms by which RSV regu¬lates mitochondrial function in diabetic cardiomyopathy have not been fully elucidated. Mitochondrial dysfunction contributes to cardiac dysfunction in diabetic patients, which is associated with dysregulation of peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α). In this study we examined whether resveratrol alleviated cardiac dysfunction in diabetes by improving mitochondrial function via SIRT1-mediated PGC-1α deacetylation...
August 3, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28764220/to-evaluate-the-change-in-brain-natriuretic-peptide-levels-in-outpatients-with-ischemic-cardiomyopathy-and-its-association-with-functional-capacity-a-pilot-study
#16
Amarapalli Jayachandra, Vivek Aggarwal
INTRODUCTION: Literature is sparse on the clinical correlation of six minute walk test (6MWT) and Brain Natriuretic Peptide (BNP) levels in ischemic Cardiomyopathy (Ischemic CMP) patients. New York Heart Association (NYHA) classification is most commonly used for functional assessment of Heart Failure (HF), which is very subjective. This limitation is overcome by 6MWT which has prognostic significance in addition to assessment of level of functional impairment. Serum BNP correlate with clinical severity of HF as assessed by NYHA class...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28758590/renin-angiotensin-system-in-diabetes
#17
Michael Bader, Johannes Rein
The renin-angiotensin system (RAS) has two different axes, the classical one with the effector peptide angiotensin II and the new one with the effector peptide angiotensin (1-7). Both peptides have been shown to be involved in the pathogenesis of diabetes mellitus and its consequences, nephropathy, retinopathy and cardiomyopathy in animal models and patients. In diabetes, angiotensin II acts mostly deleterious and angiotensin (1-7) protective. In this review we summarize the knowledge about the role of the different RAS axes in diabetes mellitus and the use of drugs interfering with the RAS in the therapy of the disease...
July 28, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28756079/-exercise-testing-new-guidelines
#18
Dany Michel Marcadet
The GERS (Exercise Rehabilitation and Sports Group of the French Society of Cardiology) has decided to update current guidelines regarding the practice of EKG stress tests. Since the last update dates from 1997, the GERS judged it necessary to integrate data from new works and advancements made in the last 20 years. Good clinical practices and safety conditions are better defined regarding the structure, location, material, staff competency, as well as convention with hospital structures. The diagnosis of coronary artery disease remains the principal indication for a stress test...
July 26, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28754449/the-role-of-nadph-oxidases-in-diabetic-cardiomyopathy
#19
REVIEW
Synne S Hansen, Ellen Aasum, Anne D Hafstad
Systemic changes during diabetes such as high glucose, dyslipidemia, hormonal changes and low grade inflammation, are believed to induce structural and functional changes in the cardiomyocyte associated with the development of diabetic cardiomyopathy. One of the hallmarks of the diabetic heart is increased oxidative stress. NADPH-oxidases (NOXs) are important ROS-producing enzymes in the cardiomyocyte mediating both adaptive and maladaptive changes in the heart. NOXs have been suggested as a therapeutic target for several diabetic complications, but their role in diabetic cardiomyopathy is far from elucidated...
July 25, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28744126/gold-nanoparticle-based-mir155-antagonist-macrophage-delivery-restores-the-cardiac-function-in-ovariectomized-diabetic-mouse-model
#20
Chengming Jia, Hui Chen, Mengying Wei, Xiangjie Chen, Yajun Zhang, Liang Cao, Ping Yuan, Fangyuan Wang, Guodong Yang, Jing Ma
Diabetic cardiomyopathy is a common disease in postmenopausal women, in whom the estrogen deficiency aggravates the pathology. In this study, we have found that estrogen deficiency due to ovariectomy aggravates the inflammation in the hearts of diabetic mice, as depicted by excessive proinflammatory type 1 macrophages (M1) over anti-inflammatory type 2 macrophages (M2). Accordingly, an additional increase of reactive oxygen species, cell apoptosis, cardiac hypertrophy, and fibrosis was observed in the hearts of ovariectomized diabetic mice, in comparison with the diabetes-only group...
2017: International Journal of Nanomedicine
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