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https://www.readbyqxmd.com/read/29028794/condensin-ii-and-gait-complexes-cooperate-to-restrict-line-1-retrotransposition-in-epithelial-cells
#1
Jacqueline R Ward, Kommireddy Vasu, Emily Deutschman, Dalia Halawani, Peter A Larson, Dongmei Zhang, Belinda Willard, Paul L Fox, John V Moran, Michelle S Longworth
LINE-1 (L1) retrotransposons can mobilize (retrotranspose) within the human genome, and mutagenic de novo L1 insertions can lead to human diseases, including cancers. As a result, cells are actively engaged in preventing L1 retrotransposition. This work reveals that the human Condensin II complex restricts L1 retrotransposition in both non-transformed and transformed cell lines through inhibition of L1 transcription and translation. Condensin II subunits, CAP-D3 and CAP-H2, interact with members of the Gamma-Interferon Activated Inhibitor of Translation (GAIT) complex including the glutamyl-prolyl-tRNA synthetase (EPRS), the ribosomal protein L13a, Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), and NS1 associated protein 1 (NSAP1)...
October 13, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29028085/nestin-and-cd146-expression-in-metaplastic-breast-cancer-stem-cell-therapy-in-need-lessons-reported-from-a-male-patient
#2
A Tampakis, E C Tampaki, D Trafalis, A Nonni, K Kontzoglou, E Patsouris, M Kontos, G Kouraklis
OBJECTIVE: Metaplastic breast carcinomas represent a rare subtype of breast cancer exhibiting aggressive clinical features. They appear as highly chemoresistant tumors, therefore showing poor outcome and high rates of local recurrence or distant metastasis. CASE REPORT: A 37-year-old greek man was referred to our hospital for evaluation of a locally advanced, ulcerated, fixed, irregular and hard in consistency mass covering his left breast and chest wall. Further work out with CT and biopsy of the tumor revealed a triple negative metaplastic breast cancer classified as cT4cN3cM1...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027279/long-non-coding-rna-pvt1-emerging-biomarker-in-digestive-system-cancer
#3
REVIEW
Dan-Dan Zhou, Xiu-Fen Liu, Cheng-Wei Lu, Om Prakash Pant, Xiao-Dong Liu
The digestive system cancers are leading cause of cancer-related death worldwide, and have high risks of morbidity and mortality. More and more long non-coding RNAs (lncRNAs) have been studied to be abnormally expressed in cancers and play a key role in the process of digestive system tumour progression. Plasmacytoma variant translocation 1 (PVT1) seems fairly novel. Since 1984, PVT1 was identified to be an activator of MYC in mice. Its role in human tumour initiation and progression has long been a subject of interest...
October 12, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29027232/immune-recognition-of-irradiated-cancer-cells
#4
REVIEW
Erik Wennerberg, Claire Vanpouille-Box, Sophia Bornstein, Takahiro Yamazaki, Sandra Demaria, Lorenzo Galluzzi
Ionizing irradiation has been extensively employed for the clinical management of solid tumors, with therapeutic or palliative intents, for decades. Until recently, radiation therapy (RT) was believed to mediate antineoplastic activity mostly (if not only) as a consequence of cancer cell-intrinsic effects. Indeed, the macromolecular damage imposed to malignant cells by RT initiates one or multiple signal transduction cascades that drive a permanent proliferative arrest (cellular senescence) or regulated cell death...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29027226/efferocytosis-of-dying-cells-differentially-modulate-immunological-outcomes-in-tumor-microenvironment
#5
REVIEW
Sushil Kumar, David Calianese, Raymond B Birge
Programmed cell death (apoptosis) is an integral part of tissue homeostasis in complex organisms, allowing for tissue turnover, repair, and renewal while simultaneously inhibiting the release of self antigens and danger signals from apoptotic cell-derived constituents that can result in immune activation, inflammation, and autoimmunity. Unlike cells in culture, the physiological fate of cells that die by apoptosis in vivo is their rapid recognition and engulfment by phagocytic cells (a process called efferocytosis)...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29027005/utility-of-the-revised-edmonton-symptom-assessment-system-esas-r-and-the-patient-reported-functional-status-prfs-in-lung-cancer-patients
#6
M N Yogananda, Valliappan Muthu, Kuruswamy Thurai Prasad, Adarsh Kohli, Digambar Behera, Navneet Singh
BACKGROUND: Symptom palliation is an important objective of treatment in advanced/metastatic lung cancer (LC). Significant psychological, minor physical symptoms and several social/emotional issues often go unnoticed. This prospective study aimed to evaluate utility of patients' perspectives [self-reported symptom assessment by revised Edmonton Symptom Assessment System (ESAS-r) and self-reported functional status by Patient-Reported Functional Status (PRFS)] amongst LC patients undergoing chemotherapy...
October 12, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29025596/rank-and-egfr-in-invasive-breast-carcinoma
#7
Anastasios D Papanastasiou, Chaido Sirinian, Eva Plakoula, Vassiliki Zolota, Ioannis K Zarkadis, Haralabos P Kalofonos
Breast cancer is the most common malignancy, affecting one in eight women in North America and Europe. The human epidermal growth factor receptor (EGFR) protein comprises a major determinant of normal development but also cancer. RANK receptor (Receptor Activator of Nuclear factor-κB) is a tumor necrosis superfamily member and a binding partner for RANKL, which was recently implicated in breast cancer initiation, progression and metastasis. Here we provide preliminary evidence of a possible interplay between RANK and EGFR signaling in breast cancer...
October 2017: Cancer Genetics
https://www.readbyqxmd.com/read/29024940/ano9-tmem16j-promotes-tumourigenesis-via-egfr-and-is-a-novel-therapeutic-target-for-pancreatic-cancer
#8
Ikhyun Jun, Hyung Soon Park, He Piao, Jung Woo Han, Min Ji An, Byeong Gyu Yun, Xianglan Zhang, Yong Hoon Cha, You Keun Shin, Jong In Yook, Jinsei Jung, Heon Yung Gee, Joon Seong Park, Dong Sup Yoon, Hei-Cheul Jeung, Min Goo Lee
BACKGROUND: Anoctamin (ANO)/transmembrane member 16 (TMEM16) proteins mediate diverse physiological and pathophysiological functions including cancer cell proliferation. The present study aimed to identify the role of ANOs in pancreatic cancer. METHODS: In an initial screen of ANOs, ANO9/TMEM16J was overexpressed in pancreatic cancer cells, and its role in the pathogenesis of pancreatic cancer was evaluated using an integrated in vitro and in vivo approach. To determine clinical relevance of the experimental findings, the prognostic value of ANO9 was evaluated in patients with pancreatic cancer...
October 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29024748/effect-of-circulating-tumor-cell-aggregate-configuration-on-hemodynamic-transport-and-wall-contact
#9
Kevin J Anderson, Adelaide de Guillebon, Andrew Hughes, Weiwei Wang, Michael R King
Selectin-mediated adhesion of circulating tumor cells (CTCs) to the endothelium is a critical step in cancer metastasis, which is a major factor contributing to the mortality of cancer. The formation of tethers between tumor cells and endothelial selectins initiates cell rolling, which leads to firm adhesion, extravasation and the formation of secondary metastases. Tumor cells can travel through the bloodstream as single cells, or as aggregates known as circulating tumor microemboli (CTM). CTM have increased survivability and metastatic potential relative to CTCs, and the presence of CTM is associated with worse patient prognosis...
October 9, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/29024634/space-invaders-brain-tumor-exploitation-of-the-stem-cell-niche
#10
REVIEW
Justine Sinnaeve, Bret C Mobley, Rebecca A Ihrie
Increasing evidence indicates that the adult neurogenic niche of the ventricular sub-ventricular zone (V-SVZ), beyond serving as a potential site of origin, affects the outcome of malignant brain cancers. Glioma contact with this niche predicts worse prognosis, suggesting a supportive role for the V-SVZ environment in tumor initiation or progression. In this review, we describe unique components of the V-SVZ that may permit or promote tumor growth within the region. Cell-cell interactions, soluble factors, and extracellular matrix composition are discussed, and the role of the niche in future therapies is explored...
October 9, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29024602/knockdown-of-cemip-suppresses-proliferation-and-induces-apoptosis-in-colorectal-cancer-cells-downregulation-of-grp78-and-attenuation-of-unfolded-protein-response
#11
Guodong Liang, Xuedong Fang, Yubo Yang, Yan Song
Cell migration inducing hyaluronan binding protein (CEMIP) has been suggested as a contributor in the carcinogenesis of colorectal cancer (CRC). Cancer cells can adapt to endoplasmic reticulum (ER) stress by initiating unfolded protein response (UPR). This study aimed at investigating whether CEMIP affected the UPR of CRC cells, with a focus on 78 kDa glucose-regulated protein (GRP78, a major ER chaperone). We found that knockdown of CEMIP inhibited cell proliferation and induced a G1 arrest in SW480 CRC cells...
October 12, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29024225/snail-mediated-cancer-stem-cell-like-phenotype-in-human-cne2-nasopharyngeal-carcinoma-cell
#12
Shan Peng, Cheng Wu, Wei Sun, Dongbo Liu, Min Luo, Beibei Su, Linli Zhang, Qi Mei, Guoqing Hu
BACKGROUND: Cancer stem cell (CSC)-like phenotype, which has been proven to play a critical role in invasion and metastasis of many kinds of cancers, has also been reported to be associated with epithelial-mesenchymal transition. Snail, a potent repressor of E-cadherin expression, was found to have a function to regulate the aforementioned processes. METHODS: In the current study, expression of putative CSCs biomarkers and the ratio of CSC-like CNE2 (cancer cell line) in total CNE2 were measured, and CSC-like characteristics were analyzed with tumor-sphere self-renewal and colony-forming assays...
October 12, 2017: Head & Neck
https://www.readbyqxmd.com/read/29023799/mir-214-activates-tp53-but-suppresses-the-expression-of-rela-ctnnb1-and-stat3-in-human-cervical-and-colorectal-cancer-cells
#13
Karthik Subramanian Chandrasekaran, Anusha Sathyanarayanan, Devarajan Karunagaran
High Mobility Group AT-hook 1 (HMGA1) was identified as a target of miR-214 in human cervical and colorectal cancers (CaCx and CRC) in a previous study. While the expression of miR-214 remains suppressed, HMGA1 behaves as a potent oncogene and plays crucial roles in several aberrant signalling pathways by interacting with intermediates like RELA, CTNNB1, STAT3, and TP53 in CaCx and CRC. Hypothetically, miR-214 should be able to regulate the stabilization of some of these intermediates through the regulation of HMGA1...
October 10, 2017: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29021969/-k-means-and-cluster-models-for-cancer-signatures
#14
Zura Kakushadze, Willie Yu
We present *K-means clustering algorithm and source code by expanding statistical clustering methods applied in https://ssrn.com/abstract=2802753 to quantitative finance. *K-means is statistically deterministic without specifying initial centers, etc. We apply *K-means to extracting cancer signatures from genome data without using nonnegative matrix factorization (NMF). *K-means' computational cost is a fraction of NMF's. Using 1389 published samples for 14 cancer types, we find that 3 cancers (liver cancer, lung cancer and renal cell carcinoma) stand out and do not have cluster-like structures...
September 2017: Biomolecular Detection and Quantification
https://www.readbyqxmd.com/read/29021921/post-transplant-lymphoproliferative-disorder-ptld-single-institutional-experience-of-141-patients
#15
Rohit Bishnoi, Ravneet Bajwa, Aaron J Franke, William Paul Skelton, Yu Wang, Niraj M Patel, William Birdsall Slayton, Fei Zou, Nam H Dang
BACKGROUND: Post-transplant lymphoproliferative disorder is a well-recognized but rare complication of hematopoietic stem cell and solid organ transplant. Due to rarity of this disease, retrospective studies from major transplant centers has been the main source to provide treatment guidelines, which are still in evolution. The sample size of this study is among one of the largest study on PTLD till date reported throughout the world. METHODS: This study was performed at University of Florida which is one of the largest transplant center in South East United States...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29021794/cd95-fas-non-apoptotic-signaling-pathways-and-kinases
#16
REVIEW
Matthieu Le Gallo, Amanda Poissonnier, Patrick Blanco, Patrick Legembre
Endothelial cells lining new blood vessels that develop during inflammatory disorders or cancers act as doors that either allow or block access to the tumor or inflamed organ. Recent data show that these endothelial cells in cancer tissues and inflamed tissues of lupus patients overexpress CD95L, the biological role of which is a subject of debate. The receptor CD95 (also named Fas or apoptosis antigen 1) belongs to the tumor necrosis factor (TNF) receptor superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29021655/robot-assisted-retroperitoneal-lymph-node-dissection-feasibility-and-outcome-in-postchemotherapy-residual-mass-in-testicular-cancer
#17
Amitabh Singh, Smaranjit Chatterjee, Prashant Bansal, Abhishek Bansal, Sudhir Rawal
INTRODUCTION: We aimed to evaluate the surgical feasibility, complication, and oncological outcome of robot-assisted retroperitoneal lymph node dissection (RA-RPLND) in patients of testicular tumor with postchemotherapy residual retroperitoneal mass. METHODS: A total of 13 patients underwent RA-RPLND between January 2012 and September 2016 at our institute. A study was started on December 2015, so data were collected retrospectively and prospectively regarding patient demography, tumor characteristics, surgical, pathological outcome, and oncological outcome...
October 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/29021621/protein-interaction-network-of-alternatively-spliced-nudcd1-isoforms
#18
Patrick Asselin-Mullen, Anaïs Chauvin, Marie-Line Dubois, Romain Drissi, Dominique Lévesque, François-Michel Boisvert
NudCD1, also known as CML66 or OVA66, is a protein initially identified as overexpressed in patients with chronic myelogenous leukemia. The mRNA of NudCD1 is expressed in heart and testis of normal tissues, and is overexpressed in several cancers. Previous studies have shown that the expression level of the protein correlates with tumoral phenotype, possibly interacting upstream of the Insulin Growth Factor - 1 Receptor (IGF-1R). The gene encoding the NudCD1 protein consists of 12 exons that can be alternative spliced, leading to the expression of three different isoforms...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021381/activation-of-fak-and-src-mediates-acquired-sorafenib-resistance-in-a549-human-lung-adenocarcinoma-xenografts
#19
Qingyu S Zhou, Xiaofang Guo, Riya Choksi
Despite encouraging clinical results with sorafenib monotherapy in patients with KRAS-mutant non-small cell lung cancer (NSCLC), the overall survival benefit of this drug is limited by the inevitable development of acquired resistance. The exact mechanism underlying acquired sorafenib resistance in KRAS-mutant NSCLC is unclear. In this study, the mechanism of acquired sorafenib resistance was explored using a biologically relevant xenograft model, which was established by using the A549 human lung adenocarcinoma cell line and an in-vivo derived sorafenib-resistant A549 subline (A549/SRFres)...
October 11, 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29021338/a-daple-akt-feed-forward-loop-enhances-non-canonical-wnt-signals-by-compartmentalizing-%C3%AE-catenin
#20
Nicolas Aznar, Nina Sun, Ying Dunkel, Jason Ear, Matthew D Buschman, Pradipta Ghosh
Cellular proliferation is antagonistically regulated by canonical and non-canonical Wnt signals; their dysbalance triggers cancers. We previously showed that a multimodular signal transducer, Daple, enhances PI3-K→Akt signals within the non-canonical Wnt signaling pathway and antagonistically inhibits canonical Wnt responses. Here we demonstrate that the PI3-K→Akt pathway serves as a positive feedback loop that further enhances non-canonical Wnt signals by compartmentalizing β-catenin. By phosphorylating the phosphoinositide(PI)-binding domain of Daple, Akt abolishes Daple's ability to bind PI3-P-enriched endosomes that engage dynein motor complex for long-distance trafficking of β-catenin/E-cadherin complexes to pericentriolar recycling endosomes (PCREs)...
October 11, 2017: Molecular Biology of the Cell
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