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https://www.readbyqxmd.com/read/28535431/partial-ablation-of-the-pancreas-of-sprague-dawley%C3%A2-rats-by-focused-ultrasound-reveals-no-significant-adverse-effects-on-glycometabolism-function
#1
Lan Ao, Na Hu, Hai Xia Hu, Qing Liu, Zi Hao Zhao, Long Xing Liu, Jun Ru Wu, Fa Qi Li, Liao Qiong Fang
To investigate the safety of focused ultrasound (FUS) partial ablation on the pancreas of Sprague Dawley® (SD) rats by histopathological examination of the outcome and investigation of glycometabolism function changes after local ablation. A total of 135 healthy SD rats were randomly divided into three groups (n=45 of each): FUS ½ group, FUS ¼ group, and control group. Levels of serum amylase was measured using the enzyme dynamics method, fasting blood glucose was measured by the glucose oxidase-peroxidase method, fasting serum insulin was measured by direct chemiluminescence assay, and an ELISA was used to measure fasting serum glucagon immediately after treatment, and at 2h, 3days, 1, 2, 3 and 4weeks, 3 and 6months after FUS ablation...
May 11, 2017: Ultrasonics
https://www.readbyqxmd.com/read/28534375/effect-of-the-combination-treatment-of-high-intensity-focused-ultrasound-and-cryocare-knife-in-advanced-liver-cancer
#2
Yuan-Peng Zhai, Yan Wang
PURPOSE: To analyze the effect of the combination treatment of high-intensity focused ultrasound (HIFU) and cryocare knife in advanced liver cancer. METHODS: 74 patients with advanced liver cancer were divided into the observation group (40 cases) and the control group (34 cases). Patients in the control group were treated with simple transcatheter arterial chemoembolization (TACE), while those in the observation group were given the combination treatment of HIFU and cryocare knife...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28532082/ultrasonic-nanotherapy-of-breast-cancer-using-novel-ultrasound-responsive-alginate-shelled-perfluorohexane-nanodroplets-in-vitro-and-in-vivo-evaluation
#3
Fatemeh Baghbani, Mahdieh Chegeni, Fathollah Moztarzadeh, Jamshid Aghazadeh Mohandesi, Manijhe Mokhtari-Dizaji
Development of a new class of multifunctional ultrasound-responsive smart nanocarriers that combine therapeutic properties with diagnostic imaging has gained great attention in recent years. Here, we describe the results of ultrasonic nanotherapy of breast cancer using novel alginate-stabilized perfluorohexane nanodroplets. Doxorubicin (Dox)-loaded multifunctional nanodroplets (Dox-NDs) were synthesized via nanoemulsion process and evaluated in vitro and in vivo with focus on cytotoxicity, hemolytic activity, biodistribution, biosafety, and antitumor activity...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28528021/multicystic-peritoneal-mesothelioma-a-short-review
#4
Chi-Hao Zhang, Ji-Wei Yu, Meng Luo
Multicystic peritoneal mesothelioma (MCPM) is a rare neoplasm, predominantly affecting female patients during their reproductive years. The lesion is usually distributed diffusely in the abdomen and pelvis, but the peritoneum of the pelvic organs is the most common site. MCPM is composed of fluid-filled translucent cysts, connected by varying amounts of fibrous tissue, and lined by a layer of mesothelial cells. Because of the rarity of this disease, the pathogenesis and natural history of MCPM remain poorly understood and continuously debated...
March 31, 2017: Current Problems in Cancer
https://www.readbyqxmd.com/read/28526455/comparison-of-3d-and-2d-shear-wave-elastography-for-differentiating-benign-and-malignant-breast-masses-focus-on-the-diagnostic-performance
#5
H Y Choi, Y-M Sohn, M Seo
AIM: To evaluate the diagnostic performance of three-dimensional (3D) image shear-wave elastography (SWE) for differentiating benign from malignant breast masses compared to two-dimensional (2D) SWE and B-mode ultrasound (US). MATERIALS AND METHODS: This study consisted of 205 breast lesions from 199 patients who underwent B-mode US and SWE before biopsy from January 2014 to March 2016. Quantitative elasticity values (maximum and mean elasticity, Emax and Emean) obtained from 2D and 3D SWE (axial, sagittal, and coronal images) were reviewed retrospectively, in addition to the histopathological findings including immunohistochemistry profiles (luminal A, luminal B, human epidermal growth factor receptor 2 (HER2)-enriched, and triple-negative breast cancer) in cases of malignancy...
May 16, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28523127/high-intensity-focused-ultrasound-hifu-ablation-of-benign-thyroid-nodules-a-systematic-review
#6
REVIEW
Brian Hung-Hin Lang, Arnold L H Wu
BACKGROUND: With an increasing number of imaging studies being done nowadays, the number of incidentally discovered thyroid nodules is expected to rise. Although many of these nodules are small and benign in nature, some do grow and may cause pressure and/or thyrotoxic symptoms. Surgical resection has traditionally been recommended for symptomatic nodules but is associated with risk of hypothyroidism, bleeding, infection, and nerve damage. High intensity focused ultrasound (HIFU) is one of the non-surgical thermal ablation techniques that may serve as an alternative in the treatment of benign thyroid nodules...
2017: Journal of Therapeutic Ultrasound
https://www.readbyqxmd.com/read/28521047/musculoskeletal-ultrasonography-for-psoriatic-arthritis-and-psoriasis-patients-a-systematic-literature-review
#7
Alen Zabotti, Francesca Bandinelli, Alberto Batticciotto, Carlo Alberto Scirè, Annamaria Iagnocco, Garifallia Sakellariou
Objective.: To systematically review the role of musculoskeletal US in patients suffering from PsA or psoriasis (Pso) in terms of prevalence, diagnosis, prognosis, monitoring and treatment. Methods.: A systematic literature review was conducted through medical databases (MEDLINE via PubMed, Embase) and the grey literature up to September 2015 to inform a new study of the Musculoskeletal Ultrasound Study Group of the Italian Society for Rheumatology. All articles reporting data on musculoskeletal US in PsA or Pso were included and extracted according to the underlying clinical question...
May 18, 2017: Rheumatology
https://www.readbyqxmd.com/read/28521010/prospective-audit-of-a-pathway-for-in-patient-pain-management-of-chronic-abdominal-pain-a-novel-and-cost-effective-strategy
#8
Gopinath Niraj, Sanjay Chaudhri
Background.:  Unexplained abdominal pain is a common cause of hospital admission and utilizes significant resource. Current in-patient pain management of acute exacerbation of chronic abdominal pain is primarily directed at pharmacological and psychological management strategies in this group of complex patients. We adopted a novel approach that proved to be both clinically effective and cost-effective. Design.:  Adult patients admitted to a surgical ward with acute exacerbation of chronic abdominal pain referred to in-patient pain management were prospectively audited over a two-year period at a single tertiary centre...
May 17, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28516051/evaluation-of-mr-thermometry-with-proton-resonance-frequency-method-at-7t
#9
Ping Wang
Quantitative and non-invasive temperature mapping using magnetic resonance imaging (MRI) provides a unique way to measure temperature evolution inside biological tissues. The method is widely used in thermal ablation procedures with magnetic fields at or below 3T. In this paper, the sensitivity of the MRI thermometry at 7T was studied using a proton resonance frequency (PRF)-based technique. We first used an agarose gel phantom with MR-compatible thermometry to calibrate the temperature coefficient, and then this temperature coefficient was employed to measure the internal temperature in both ex vivo (beef muscle) and in vivo (rat) experiments using focused ultrasound heating...
April 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28514289/anti-angiogenic-therapy-with-contrast-enhanced-ultrasound-in-colorectal-cancer-patients-with-liver-metastasis
#10
Zhiyong Wu, Xiaowei Yang, Li Chen, Zhikuan Wang, Yan Shi, Hui Mao, Guanghai Dai, Xiaoling Yu
The aim of the study was to evaluate the efficacy of anti-angiogenic therapy with dynamic contrast-enhanced ultrasound (DCE-US) in colorectal cancer (CRC) patients with liver metastasis.A total of 50 CRC patients with liver metastasis who received bevacizumab (BEV)-based chemotherapy (BEV + FOLFOX6 protocol) were recruited into the present study. Before the study (d0), and 3, 7, 14, and 42 days (d3, d7, d14, and d42) after chemotherapy, DCE-US was performed, and tumor perfusion was evaluated quantitatively by retention time (RT), peak enhancement (PE), and wash-in area under the curve (WiAUC) on the basis of a contrast-uptake curve determined with original linear data...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28513733/polylactic-acid-nano-and-microchamber-arrays-for-encapsulation-of-small-hydrophilic-molecules-featuring-drug-release-via-high-intensity-focused-ultrasound
#11
Meiyu Gai, Johannes Frueh, Tianyi Tao, Arseniy V Petrov, Vladimir V Petrov, Evgeniy V Shesterikov, Sergei I Tverdokhlebov, Gleb B Sukhorukov
Long term encapsulation combined with spatiotemporal release for a precisely defined quantity of small hydrophilic molecules on demand remains a challenge in various fields ranging from medical drug delivery, controlled release of catalysts to industrial anti-corrosion systems. Free-standing individually sealed polylactic acid (PLA) nano- and microchamber arrays were produced by one-step dip-coating a PDMS stamp into PLA solution for 5 s followed by drying under ambient conditions. The wall thickness of these hydrophobic nano-microchambers is tunable from 150 nm to 7 μm by varying the PLA solution concentration...
May 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28512580/high-intensity-focused-ultrasound-circular-cyclocoagulation-in-glaucoma-a-step-forward-for-cyclodestruction
#12
REVIEW
Rodolfo Mastropasqua, Vincenzo Fasanella, Alessandra Mastropasqua, Marco Ciancaglini, Luca Agnifili
The ciliary body ablation is still considered as a last resort treatment to reduce the intraocular pressure (IOP) in uncontrolled glaucoma. Several ablation techniques have been proposed over the years, all presenting a high rate of complications, nonselectivity for the target organ, and unpredictable dose-effect relationship. These drawbacks limited the application of cyclodestructive procedures almost exclusively to refractory glaucoma. High-intensity focused ultrasound (HIFU), proposed in the early 1980s and later abandoned because of the complexity and side effects of the procedure, was recently reconsidered in a new approach to destroy the ciliary body...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28511228/the-100-most-cited-articles-focused-on-ultrasound-imaging-a-bibliometric-analysis
#13
J Y Moon, E J Yun, D Y Yoon, C S Choi, Y L Seo, Y K Cho, K J Lim, S Baek, S J Hong, S J Yoon
Purpose The number of citations that an article has received reflects its impact on a particular research area. The aim of this study was to identify the 100 most-cited articles focused on ultrasound (US) imaging and to analyze the characteristics of these articles. Methods We determined the 100 most-cited articles on US imaging via the Web of Science database, using the search term. The following parameters were used to analyze the characteristics of the 100 most-cited articles: publication year, journal, journal impact factor, number of citations and annual citations, authors, department, institution, country, type of article, and topic...
May 16, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28511225/comment-on-the-100-most-cited-articles-focused-on-ultrasound-imaging-a-bibliometric-analysis
#14
Michael Bachmann Nielsen
No abstract text is available yet for this article.
May 16, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28511006/novel-focused-ultrasound-gene-therapy-approach-noninvasively-restores-dopaminergic-neuron-function-in-a-rat-parkinson-s-disease-model
#15
Brian P Mead, Namho Kim, G Wilson Miller, David Hodges, Panagiotis Mastorakos, Alexander L Klibanov, James W Mandell, Jay Hirsh, Jung Soo Suk, Justin Hanes, Richard J Price
Therapies capable of decelerating, or perhaps even halting, neurodegeneration in Parkinson's disease (PD) remain elusive. Clinical trials of PD gene therapy testing the delivery of neurotrophic factors, such as the glial cell-line derived neurotrophic factor (GDNF), have been largely ineffective due to poor vector distribution throughout the diseased regions in the brain. In addition, current delivery strategies involve invasive procedures that obviate the inclusion of early stage patients who are most likely to benefit from GDNF-based gene therapy...
May 18, 2017: Nano Letters
https://www.readbyqxmd.com/read/28510070/sonographic-detection-of-open-spina-bifida-in-the-first-trimester-review-of-the-literature
#16
César Meller, Horacio Aiello, Lucas Otaño
In the beginnings, sonographic diagnosis of open spina bifida (OSB) relied on the meticulous scanning of the fetal vertebrae for abnormalities but many defects were missed. After the mid-1980s, however, with the description of the intracranial findings in the second trimester (the "lemon sign" and the "banana sign"), the prenatal diagnosis of OSB was enhanced. In the last 2 decades, there has been widespread uptake of routine ultrasound examination in the first trimester of pregnancy with the purpose of the measurement of fetal crown-rump length to determine gestational age, to screen for trisomy 21 and other aneuploidies, mainly with the nuchal translucency, and for diagnosis of many major abnormalities...
May 16, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28509682/new-neurosurgical-approaches-for-tremor-and-parkinson-s-disease
#17
Alfonso Fasano, Andres M Lozano, Esther Cubo
PURPOSE OF REVIEW: The objective of this review is to gather the newest advances in the surgical treatment of tremor and Parkinson's disease. We will briefly discuss the potential applications of the new technologies of deep brain stimulation (DBS), and we will focus on MRI-guided focused ultrasound (MRgFUS). RECENT FINDINGS: Novel DBS devices are being progressively adopted, particularly electrodes allowing a longer stimulating surface (suitable for multiple targets stimulation) and current radial steering (to minimize side effects of stimulation)...
May 13, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28509402/a-combined-hands-on-teaching-program-and-clinical-pathway-focused-on-pleural-ultrasound-and-procedure-supervision-transforms-pleural-procedure-outcomes
#18
Timothy Edwards, Alistair Cook, Matthew Salamonsen, Farzad Bashirzadeh, David Fielding
INTRODUCTION: Management of pleural effusions is a common diagnostic and management problem. We reviewed the outcomes from pleural procedures after the instigation of pleural effusion management guidelines focusing on pleural ultrasound and a hands-on teaching program followed with procedure supervision that enabled many operators to perform such procedures. METHODS: A retrospective analysis of all procedures performed for pleural effusions on medical patients. Outcomes were assessed prior to the instigation of pleural effusion management guidelines (pleural pathway) and hands-on teaching (January 2010 to June 2011) and following these interventions (January 2012 to June 2013)...
May 16, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28508343/cytomegalovirus-infection-in-pregnancy
#19
REVIEW
Karl Oliver Kagan, Klaus Hamprecht
PURPOSE: Due to the severe risk of long-term sequelae, prenatal cytomegalovirus infection is of particular importance amongst intrauterine viral infections. This review summarizes the current knowledge about CMV infection in pregnancy. METHODS: A search of the Medline and Embase database was done for articles about CMV infection in pregnany. We performed a detailed review of the literature in view of diagnosis, epidemiology and management of CMV infection in pregnancy...
May 15, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28507052/correction-pulsed-high-intensity-focused-ultrasound-enhances-delivery-of-doxorubicin-in-a-preclinical-model-of-pancreatic-cancer
#20
(no author information available yet)
No abstract text is available yet for this article.
May 15, 2017: Cancer Research
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