keyword
https://read.qxmd.com/read/38536559/radiomics-based-machine-learning-in-the-differentiation-of-benign-and-malignant-bowel-wall-thickening-radiomics-in-bowel-wall-thickening
#1
JOURNAL ARTICLE
Hande Melike Bülbül, Gülen Burakgazi, Uğur Kesimal, Esat Kaba
PURPOSE: To distinguish malignant and benign bowel wall thickening (BWT) by using computed tomography (CT) texture features based on machine learning (ML) models and to compare its success with the clinical model and combined model. METHODS: One hundred twenty-two patients with BWT identified on contrast-enhanced abdominal CT and underwent colonoscopy were included in this retrospective study. Texture features were extracted from CT images using LifeX software. Feature selection and reduction were performed using the Least Absolute Shrinkage and Selection Operator (LASSO)...
March 27, 2024: Japanese Journal of Radiology
https://read.qxmd.com/read/38533666/diagnostic-accuracy-of-the-ifn-%C3%AE-release-assay-using-rd1-immunodominant-t-cell-antigens-for-diagnosis-of-extrapulmonary-tuberculosis
#2
JOURNAL ARTICLE
Setareh Mamishi, Babak Pourakbari, Reihaneh Hosseinpour Sadeghi, Majid Marjani, Shima Mahmoudi
The diagnosis of extrapulmonary tuberculosis (EPTB) poses a significant challenge, with controversies surrounding the accuracy of IFN-γ release assays (IGRAs). This study aimed to assess the diagnostic accuracy of RD1 immunodominant T-cell antigens, including ESAT-6, CFP-10, PE35, and PPE68 proteins, for immunodiagnosis of EPTB. Twenty-nine patients with EPTB were enrolled, and recombinant PE35, PPE68, ESAT-6, and CFP-10 proteins were evaluated in a 3-day Whole Blood Assay. IFN-γ levels were measured using a Human IFN-γ ELISA kit, and the QuantiFERON-TB Gold Plus (QFT-Plus) test was performed...
March 26, 2024: FEMS Microbiology Letters
https://read.qxmd.com/read/38459038/bcg-booster-vaccination-with-hsp90-esat-6-hspx-ripa-multivalent-subunit-vaccine-confers-durable-protection-against-hypervirulent-mtb-in-mice
#3
JOURNAL ARTICLE
Kee Woong Kwon, Han-Gyu Choi, Kwang Sung Kim, Shin Ae Park, Hwa-Jung Kim, Sung Jae Shin
The quest for effective and enhanced multiantigenic tuberculosis (TB) subunit vaccine necessitates the induction of a protective pathogen-specific immune response while circumventing detrimental inflammation within the lung milieu. In line with this goal, we engineered a modified iteration of the quadrivalent vaccine, namely HSP90-ESAT-6-HspX-RipA (HEHR), which was coupled with the TLR4 adjuvant, CIA09A. The ensuing formulation was subjected to comprehensive assessment to gauge its protective efficacy against the hypervirulent Mycobacterium tuberculosis (Mtb) Haarlem clinical strain M2, following a BCG-prime boost regimen...
March 8, 2024: NPJ Vaccines
https://read.qxmd.com/read/38447026/zero-single-and-few-shot-learning-in-large-language-models-to-identify-incidental-findings-from-radiology-reports
#4
JOURNAL ARTICLE
Esat Kaba
No abstract text is available yet for this article.
March 6, 2024: AJR. American Journal of Roentgenology
https://read.qxmd.com/read/38445877/the-antagonistic-transcription-factors-espm-and-espn-regulate-the-esx-1-secretion-system-in-m-marinum
#5
JOURNAL ARTICLE
Kathleen R Nicholson, Rachel M Cronin, Rebecca J Prest, Aruna R Menon, Yuwei Yang, Madeleine K Jennisch, Matthew M Champion, David M Tobin, Patricia A Champion
Bacterial pathogens use protein secretion systems to transport virulence factors and regulate gene expression. Among pathogenic mycobacteria, including Mycobacterium tuberculosis and Mycobacterium marinum , the ESAT-6 system 1 (ESX-1) secretion is crucial for host interaction. Secretion of protein substrates by the ESX-1 secretion system disrupts phagosomes, allowing mycobacteria cytoplasmic access during macrophage infections. Deletion or mutation of the ESX-1 system attenuates mycobacterial pathogens. Pathogenic mycobacteria respond to the presence or absence of the ESX-1 system in the cytoplasmic membrane by altering transcription...
March 6, 2024: MBio
https://read.qxmd.com/read/38438203/female-sexual-dysfunction-in-urinary-and-double-incontinence
#6
JOURNAL ARTICLE
Murat Yavuz Koparal, Serhat Çetin, Ender Cem Bulut, Mecit Gürhan Ceylan, Esat Ak, Metin Onaran, İlker Şen
OBJECTIVES: To evaluate the sexual function of women with urinary incontinence (UI) and double incontinence (DI) comparing with a healthy control group by using the Female Sexual Function Index (FSFI). METHODS: This study was designed as a retrospective study consisting of UI, DI, and a control group, each containing age-matched 40 patients. Statistical comparisons were made among the UI, DI, and control groups in terms of the FSFI total score as well as each domain's score...
March 2024: Saudi Medical Journal
https://read.qxmd.com/read/38431533/effects-of-hydronephrosis-on-the-surgical-outcomes-of-fluoroscopically-guided-supine-percutaneous-nephrolithotomy
#7
JOURNAL ARTICLE
Cem Yucel, Mert Hamza Ozbilen, Cagdas Bildirici, Enes Dumanli, Esat Kaan Akbay, Mehmet Yoldas, Tufan Sueluzgen, Mehmet Zeynel Keskin
PURPOSE: To evaluate the effect of hydronephrosis on operation success and the development of complications in supine percutaneous nephrolithotomy (PCNL). METHODS: A total 259 patients were included in the study who underwent supine PCNL in our clinic between September 2019 and November 2023. The patients were divided into four groups: normal, mild, moderate and severe, according to their preoperative hydronephrosis degrees. Demographic data, kidney stone characteristics, clinical aspects, surgical findings, and postoperative complications were compared across groups...
March 2, 2024: International Urology and Nephrology
https://read.qxmd.com/read/38429734/changes-of-mycobacterium-tuberculosis-specific-antigen-stimulated-cd27-cd38-ifn-%C3%AE-cd4-t-cells-before-and-after-anti-tuberculosis-treatment
#8
JOURNAL ARTICLE
Yong Fang, Yuan Tang, Qiao-Xia Luo, Na Wang, Liang Tang, Xiao-Jun Yang, Xiao-Fang You, Yu-Chun Wang, Li Liang, Jing-Bo Zhang, Bo Su, Wei Sha
BACKGROUND: The aim of the study was to investigate whether the expression of CD27- CD38+ in interferon (IFN)-γ+ CD4+ T cells stimulated by the specific antigen early secreted antigenic target-6 (ESAT-6)/culture filter protein-10 (CFP-10) could be a potential new therapeutic evaluation indicator for anti-tuberculosis (TB) treatment. METHODS: Newly diagnosed active pulmonary TB patients, latent TB infection (LTBI) and healthy controls were enrolled from January 2021 to December 2021...
March 1, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38395846/comparative-analysis-of-tuberculin-and-defined-antigen-skin-tests-for-detection-of-bovine-tuberculosis-in-buffaloes-bubalus-bubalis-in-haryana-state-india
#9
JOURNAL ARTICLE
Mohit Kumar, Tarun Kumar, Babu Lal Jangir, Mahavir Singh, Devan Arora, Yogesh Bangar, Andrew Conlan, Martin Vordermeier, Douwe Bakker, S M Byregowda, Sreenidhi Srinivasan, Vivek Kapur, Naresh Jindal
BACKGROUND: Bovine tuberculosis (bTB) is a chronic disease that results from infection with any member of the Mycobacterium tuberculosis complex. Infected animals are typically diagnosed with tuberculin-based intradermal skin tests according to World Organization of Animal Health which are presently in use. However, tuberculin is not suitable for use in BCG-vaccinated animals due to a high rate of false-positive reactions. Peptide-based defined skin test (DST) antigens have been identified using antigens (ESAT-6, CFP-10 and Rv3615c) which are absent from BCG, but their performance in buffaloes remains unknown...
February 23, 2024: BMC Veterinary Research
https://read.qxmd.com/read/38379298/analyzing-the-impact-of-synthetic-and-natural-steroids-a-study-of-cytochrome-p450-metabolism-morphological-alterations-through-metabolomics-and-histopathological-examination
#10
JOURNAL ARTICLE
Esat Mahmut Kocaman, Onur Şenol, Serkan Yıldırım, Muhammed Atamanalp, Sinan Özcan, İsmail Bolat, Arzu Ucar, Metin Kiliçlioğlu, Veysel Parlak, Mehmet Takkac, Gonca Alak
This study focuses on the comparative metabolic profiling and effects of two steroid types: natural and synthetic, specifically 17α-methyl testosterone (17α-MT) at varying concentrations (1.5, 2, and 3 mg/kg) in rainbow trout ( Oncorhynchus mykiss ). Over a 75-day feeding trial, growth metrics such as feed efficiency, daily specific growth, live weight gain, total weight gain, and survival rate were systematically monitored every 15 days. At the end of the feeding trial, histopathology, immunohistochemistry, and metabolome analyses were performed in the high-concentration groups (3 mg/kg natural and 3 mg/kg synthetic), in which the lowest survival rate was determined...
February 20, 2024: Toxicology Mechanisms and Methods
https://read.qxmd.com/read/38378075/very-high-energy-electron-therapy-as-light-particle-alternative-to-transmission-proton-flash-therapy-an-evaluation-of-dosimetric-performances
#11
JOURNAL ARTICLE
Till Tobias Böhlen, Jean-François Germond, Laurent Desorgher, Izabella Veres, Andreas Bratel, Eric Landström, Erik Engwall, Fernanda G Herrera, Esat Mahmut Ozsahin, Jean Bourhis, François Bochud, Raphaël Moeckli
PURPOSE: Clinical translation of FLASH-radiotherapy (RT) to deep-seated tumours is still a technological challenge. One solution consists of using ultra-high dose rate transmission proton (TP) beams of about 200-250MeV to irradiate the tumour with the flat entrance of the proton depth-dose profile. This work evaluates the dosimetric performance of very high-energy electron (VHEE)-based RT (50-250MeV) as a potential alternative to TP-based RT for the clinical transfer of the FLASH effect...
February 18, 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38377627/design-and-development-of-multiepitope-chimeric-antigens-by-bioinformatic-and-bacterial-based-recombinant-expression-methods-with-potential-application-for-bovine-tuberculosis-serodiagnosis
#12
JOURNAL ARTICLE
Cassiano Martin Batista, Josir Laine Veschi, Vanessa Felipe de Souza, Leonardo Foti, Lea Chapaval Andri
Bovine tuberculosis (bTB), which is caused by Mycobacterium bovis, is a single health concern, which causes economic losses, is a sanitary barrier and is a zoonotic concern. The golden-pattern intradermic tests have low sensitivity of about 50%. To fix this sensitivity problem, immunoassays could be a powerful tool. However, few studies produced antigens for bTB immunoassays, which needs improvements. Aim of this study was to produce multiepitope chimeric antigens (MCA) to use for bTB diagnosis. To achieve MCA design and development, extensive bibliographic search, antigenic epitope prediction, specificity, hydrophobicity, and 3D structure modeling analyses were performed, as well as cloning, expression and purification...
February 13, 2024: Veterinary Immunology and Immunopathology
https://read.qxmd.com/read/38358609/aso-visual-abstract-low-dose-radiation-yields-lower-rates-of-pathologic-response-in-esophageal-cancer-patients
#13
JOURNAL ARTICLE
Styliani Mantziari, Hugo Teixeira Farinha, Marguerite Messier, Michael Winiker, Pierre Allemann, Esat Mahmut Ozsahin, Nicolas Demartines, Guillaume Piessen, Markus Schäfer
No abstract text is available yet for this article.
February 15, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38356503/optimization-of-adaptive-neuro-fuzzy-inference-system-anfis-parameters-via-box-behnken-experimental-design-approach-the-prediction-of-chromium-adsorption
#14
JOURNAL ARTICLE
Dilek Duranoğlu, Esat Sinan Altın, İlknur Küçük
Prediction of adsorption via Adaptive Neuro-Fuzzy Inference System (ANFIS) can save the cost and time in practical applications. Chromium (VI) adsorption data obtained at different temperature, activated carbon dosage and pH values were evaluated by using MATLAB ANFIS. In order to achieve prediction of adsorption via ANFIS with acceptable error values, optimum membership function (MF) and optimum number of MF were determined by using Box-Behnken experimental design (BBD) method. In order to determine the optimum number of MF for each input, all combinations given in BBD matrix were examined via ANFIS, then, regression models for each MFs were developed between the root mean square error (RMSE) and MF numbers of each input...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38342063/exploring-the-immunogenicity-of-rv2201-519-a-t-cell-epitope-based-antigen-derived-from-mycobacterium-tuberculosis-asnb-with-implications-for-tuberculosis-infection-detection-and-vaccine-development
#15
JOURNAL ARTICLE
Xiuli Luan, Xueting Fan, Guilian Li, Mchao Li, Na Li, Yuhan Yan, Xiuqin Zhao, Haican Liu, Kanglin Wan
Research dedicated to diagnostic reagents and vaccine development for tuberculosis (TB) is challenging due to the paucity of immunodominant antigens that can predict disease risk and exhibit protective potential. Therefore, it is crucial to identify T-cell epitope-based Mycobacterium tuberculosis (MTB) antigens characterized by specific and prominent recognition by the immune system. In this study, we constructed a T-cell epitope-rich tripeptide-splicing fragment (nucleotide positions 131-194, 334-377, and 579-643) of Rv2201 (also known as the 72 kDa AsnB)from the MTB genome, ultimately yielding the recombinant protein Rv2201-519 in Escherichia coli BL21 (DE3)...
February 10, 2024: International Immunopharmacology
https://read.qxmd.com/read/38339906/spatiotemporal-signal-space-separation-for-regions-of-interest-application-for-extracting-neuromagnetic-responses-evoked-by-deep-brain-stimulation
#16
JOURNAL ARTICLE
Ashwini Oswal, Bahman Abdi-Sargezeh, Abhinav Sharma, Tolga Esat Özkurt, Samu Taulu, Nagaraja Sarangmat, Alexander L Green, Vladimir Litvak
Magnetoencephalography (MEG) recordings are often contaminated by interference that can exceed the amplitude of physiological brain activity by several orders of magnitude. Furthermore, the activity of interference sources may spatially extend (known as source leakage) into the activity of brain signals of interest, resulting in source estimation inaccuracies. This problem is particularly apparent when using MEG to interrogate the effects of brain stimulation on large-scale cortical networks. In this technical report, we develop a novel denoising approach for suppressing the leakage of interference source activity into the activity representing a brain region of interest...
February 1, 2024: Human Brain Mapping
https://read.qxmd.com/read/38331624/pulmonary-artery-pseudoaneurysms-in-cannonball-metastases
#17
JOURNAL ARTICLE
Esat Kaba, Merve Solak, Nur Hürsoy
No abstract text is available yet for this article.
January 19, 2024: Archivos de Bronconeumología
https://read.qxmd.com/read/38313439/evaluation-of-thiol-disulfide-interrelation-in-major-depressive-disorder
#18
JOURNAL ARTICLE
Özlem Beğinoğlu, Mehmet Asoğlu, Esat Sabuncu, Hakim Çelik
OBJECTIVE: Although major depressive disorder (MDD) constitutes a significant part of mental health problems, its pathogenesis has not been fully elucidated. The inadequacy of diagnostic tests specific to MDD causes difficulty in diagnosis. Therefore, we investigated the situation of thiol/disulfide imbalance, which may play a role in the pathogenesis of many diseases, in MDD patients. METHODS: Forty-five MDD patients and 40 non-patient volunteers participated in our study...
November 2023: Alpha Psychiatry
https://read.qxmd.com/read/38312835/the-uncharted-territory-of-host-pathogen-interaction-in-tuberculosis
#19
REVIEW
Antara Ghoshal, Akanksha Verma, Ashima Bhaskar, Ved Prakash Dwivedi
Mycobacterium tuberculosis ( M.tb ) effectively manipulates the host processes to establish the deadly respiratory disease, Tuberculosis (TB). M.tb has developed key mechanisms to disrupt the host cell health to combat immune responses and replicate efficaciously. M.tb antigens such as ESAT-6, 19kDa lipoprotein, Hip1, and Hsp70 destroy the integrity of cell organelles (Mitochondria, Endoplasmic Reticulum, Nucleus, Phagosomes) or delay innate/adaptive cell responses. This is followed by the induction of cellular stress responses in the host...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38289481/microneedle-patch-based-enzyme-linked-immunosorbent-assay-to-quantify-protein-biomarkers-of-tuberculosis
#20
JOURNAL ARTICLE
Youngeun Kim, Mary Beth Lewis, Jihyun Hwang, Zheyu Wang, Rohit Gupta, Yuxiong Liu, Tuhina Gupta, James P Barber, Srikanth Singamaneni, Fred Quinn, Mark R Prausnitz
There is a clinical need for differential diagnosis of the latent versus active stages of tuberculosis (TB) disease by a simple-to-administer test. Alpha-crystallin (Acr) and early secretory antigenic target-6 (ESAT-6) are protein biomarkers associated with the latent and active stages of TB, respectively, and could be used for differential diagnosis. We therefore developed a microneedle patch (MNP) designed for application to the skin to quantify Acr and ESAT-6 in dermal interstitial fluid by enzyme-linked immunosorbent assay (ELISA)...
January 30, 2024: Biomedical Microdevices
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