keyword
MENU ▼
Read by QxMD icon Read
search

Esat

keyword
https://www.readbyqxmd.com/read/29756946/airy-wave-packets-accelerating-in-space-time
#1
H Esat Kondakci, Ayman F Abouraddy
Although diffractive spreading is an unavoidable feature of all wave phenomena, certain waveforms can attain propagation invariance. A lesser-explored strategy for achieving optical self-similar propagation exploits the modification of the spatiotemporal field structure when observed in reference frames moving at relativistic speeds. For such an observer, it is predicted that the associated Lorentz boost can bring to a halt the axial dynamics of a wave packet of an arbitrary profile. This phenomenon is particularly striking in the case of a self-accelerating beam-such as an Airy beam-whose peak normally undergoes a transverse displacement upon free propagation...
April 20, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29737367/the-transmembrane-domain-of-the-staphylococcus-aureus-esat-6-component-essb-mediates-interaction-with-the-integral-membrane-protein-esaa-facilitating-partially-regulated-secretion-in-a-heterologous-host
#2
Manar M Ahmed, Khaled M Aboshanab, Yasser M Ragab, Dominique M Missiakas, Khaled A Aly
The ESAT-6-like secretion system (ESS) of Staphylococcus aureus plays a significant role in persistent infections. EssB is a highly conserved bitopic ESS protein comprising a cytosolic N-terminus, single transmembrane helix and a C-terminus located on the trans-side of the membrane. Six systematic truncations covering various domains of EssB were constructed, followed by bacterial two-hybrid screening of their interaction with EsaA, another conserved integral membrane component of the ESS pathway. Results show that the transmembrane domain of EssB is critical for heterodimerization with EsaA...
May 8, 2018: Archives of Microbiology
https://www.readbyqxmd.com/read/29732235/development-of-new-preventive-and-therapeutic-vaccines-for-tuberculosis
#3
REVIEW
Bo-Eun Kwon, Jae-Hee Ahn, Seunghwan Min, Hyeongseop Kim, Jungheun Seo, Sang-Gu Yeo, Hyun-Jeong Ko
Tuberculosis (TB) is a contagious disease that has been responsible for the death of one billion people in the last 200 years. Until now, the only vaccine approved for the prevention of TB is Bacillus Calmette-Guérin (BCG), which is prepared by attenuating Mycobacterium bovis . However, one of the limitations of BCG is that its preventive effect against pulmonary TB varies from person to person. Therefore, there arises a need for a new TB vaccine to replace or supplement BCG. In this review, we have summarized the findings of current clinical trials on preventive and therapeutic TB vaccine candidates...
April 2018: Immune Network
https://www.readbyqxmd.com/read/29729920/immunoproteomics-to-identify-staphylococcus-aureus-antigens-expressed-in-bovine-milk-during-mastitis
#4
N Misra, X Pu, D N Holt, M A McGuire, J K Tinker
Staphylococcus aureus is an opportunistic pathogen affecting both human and animal species. An effective vaccine to prevent S. aureus bovine disease and transmission would have positive effects on animal well-being, food production, and human health. The objective of this study was to identify multiple antigens that are immunoreactive during udder colonization and disease for exploration as vaccine antigens to prevent bovine mastitis. Staphylococcus aureus produces several cell wall-anchored and surface-associated virulence factors that play key roles in the pathogenesis of mastitis...
May 2, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29699790/immunological-and-physical-evaluation-of-the-multistage-tuberculosis-subunit-vaccine-candidate-h56-caf01-formulated-as-a-spray-dried-powder
#5
Aneesh Thakur, Pall Thor Ingvarsson, Signe Tandrup Schmidt, Fabrice Rose, Peter Andersen, Dennis Christensen, Camilla Foged
Liquid vaccine dosage forms have limited stability and require refrigeration during their manufacture, distribution and storage. In contrast, solid vaccine dosage forms, produced by for example spray drying, offer improved storage stability and reduced dependence on cold-chain facilities. This is advantageous for mass immunization campaigns for global public health threats, e.g., tuberculosis (TB), and offers cheaper vaccine distribution. The multistage subunit vaccine antigen H56, which is a fusion protein of the Mycobacterium tuberculosis (Mtb) antigens Ag85B, ESAT-6, and Rv2660, has been shown to confer protective efficacy against active TB before and after Mtb exposure in preclinical models, and it is currently undergoing clinical phase 2a testing...
April 23, 2018: Vaccine
https://www.readbyqxmd.com/read/29699491/live-attenuated-salmonella-typhimurium-vaccines-delivering-saesxa-and-saesxb-via-type-iii-secretion-system-confer-protection-against-staphylococcus-aureus-infection
#6
Chen Xu, Bao-Zhong Zhang, Qiubin Lin, Jian Deng, Bin Yu, Smriti Arya, Kwok-Yung Yuen, Jian-Dong Huang
BACKGROUND: Staphylococcus aureus (S. aureus) causes a wide range of infectious diseases in human and animals. The emergence of antibiotic-resistant strains demands novel strategies for prophylactic vaccine development. In this study, live attenuated S. enterica subsp. enterica serotype Typhimurium (S. Typhimurium) vaccine against S. aureus infection was developed, in which Salmonella Pathogenesis Island-1 Type 3 Secretion System (SPI-1 T3SS) was employed to deliver SaEsxA and SaEsxB, two of ESAT-6-like (Early Secreted Antigenic Target-6) virulence factors of S...
April 25, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29695323/evaluation-of-mycobacteria-specific-gamma-interferon-and-antibody-responses-before-and-after-a-single-intradermal-skin-test-in-cattle-naturally-exposed-to-m-avium-subsp-paratuberculosis-and-experimentally-infected-with-m-bovis
#7
Virginie Roupie, Elena Alonso-Velasco, Sarah Van Der Heyden, Sébastien Holbert, Lucille Duytschaever, Patricia Berthon, Iris Van Dosselaer, Willem Van Campe, Laurent Mostin, Franck Biet, Stefan Roels, Kris Huygen, David Fretin
This study reports on the diagnostic potential of IFN-γ release assays and serology for Mycobacterium bovis in six naturally M. avium subsp. paratuberculosis (Map) exposed bulls of which four were intratracheally infected with a Belgian field strain of M. bovis. Heparinized blood, serum and fecal samples were collected at regular time intervals for mycobacteria-specific IFN-γ release assays, antibody analysis and for Map culture respectively. Single intradermal skin test (SIT) with bovine tuberculin (PPD-B) was performed on day 115 and animals were sacrificed on day 133 after M...
February 2018: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/29670633/extracellular-sphingomyelinase-rv0888-of-mycobacterium-tuberculosis-contributes-to-pathological-lung-injury-of-mycobacterium-smegmatis-in-mice-via-inducing-formation-of-neutrophil-extracellular-traps
#8
Guanghui Dang, Yingying Cui, Lei Wang, Tiantian Li, Ziyin Cui, Ningning Song, Liping Chen, Hai Pang, Siguo Liu
Mycobacterium tuberculosis is the causative agent of tuberculosis (TB), which mainly causes pulmonary injury and tubercles. Although macrophages are generally considered to harbor the main cells of M. tuberculosis , new evidence suggests that neutrophils are rapidly recruited to the infected lung. M. tuberculosis itself, or its early secreted antigenic target protein 6 (ESAT-6), can induce formation of neutrophil extracellular traps (NETs). However, NETs trap mycobacteria but are unable to kill them. The role of NETs' formation in the pathogenesis of mycobacteria remains unclear...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29651474/phase-transition-dynamics-of-single-optically-trapped-aqueous-potassium-carbonate-particles
#9
Kıvanç Esat, Grégory David, Theodoros Poulkas, Mikhail Shein, Ruth Signorell
Fast dynamics (down to 10 ms) during exposure to changing relative humidity of single optically trapped K2CO3 particles were observed in the submicron to micron size range with time-resolved broadband light scattering and Raman spectroscopy. The study shows that complex multiple processes accompany efflorescence and deliquescence of unsupported aerosol particles. Efflorescence can occur in a single process in less than 10 ms (prompt) or proceed via multiple successive processes (multistep) that can last up to more than 10 seconds...
April 13, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29644007/impact-of-adjuvant-hormonotherapy-on-radiation-induced-breast-fibrosis-according-to-the-individual-radiosensitivity-results-of-a-multicenter-prospective-french-trial
#10
Céline Bourgier, Florence Castan, Olivier Riou, Tan-Dat Nguyen, Karine Peignaux, Claire Lemanski, Jean-Léon Lagrange, Youlia Kirova, Eric Lartigau, Yazid Belkacemi, Sofia Rivera, Georges Noël, Sébastien Clippe, Françoise Mornex, Christophe Hennequin, Sophie Gourgou, Muriel Brengues, Pascal Fenoglietto, Esat Mahmut Ozsahin, David Azria
Background: To evaluate risk of severe breast fibrosis occurrence in patients treated by breast-conserving surgery, adjuvant radiotherapy and hormonotherapy (HT) according to individual radiosensitivity (RILA assay). Results: HT- and RILAhigh were the two independent factors associated with improved breast-fibrosis free survival (BFFS). BFFS rate at 36 months was lower in patients with RILAlow and HT+ than in patients with RILAhigh and HT- (75.8% and 100%, respectively; p = 0...
March 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29599184/rapid-diagnosis-of-pulmonary-tuberculosis-by-combined-molecular-and-immunological-methods
#11
Claudia Jafari, Ioana D Olaru, Franziska Daduna, Martin Ernst, Jan Heyckendorf, Christoph Lange, Barbara Kalsdorf
Diagnosing pulmonary tuberculosis (TB) may be delayed until culture results become available.We ascertained the accuracy of a stepwise diagnostic algorithm for the rapid diagnosis of pulmonary TB by GeneXpert from sputum and/or bronchoalveolar lavage (BAL) followed by a Mycobacterium tuberculosis- specific BAL ELISPOT assay in patients with a suspected diagnosis of pulmonary TB at a clinical referral centre in Germany.Among 166 patients with a presumptive diagnosis of pulmonary TB, 81 cases were confirmed by M...
May 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29590635/identification-of-protective-postexposure-mycobacterial-vaccine-antigens-using-an-immunosuppression-based-reactivation-model-in-the-zebrafish
#12
Henna Myllymäki, Mirja Niskanen, Hanna Luukinen, Mataleena Parikka, Mika Rämet
Roughly one third of the human population carries a latent Mycobacterium tuberculosis infection, with a 5-10% lifetime risk of reactivation to active tuberculosis and further spreading the disease. The mechanisms leading to the reactivation of a latent Mycobacterium tuberculosis infection are insufficiently understood. Here, we used a natural fish pathogen, Mycobacterium marinum , to model the reactivation of a mycobacterial infection in the adult zebrafish ( Danio rerio ). A low-dose intraperitoneal injection (∼40 colony-forming units) led to a latent infection, with mycobacteria found in well-organized granulomas surrounded by a thick layer of fibrous tissue...
March 13, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29578890/static-and-dynamic-pupillary-characteristics-in-clinically-unilateral-pseudoexfoliation-syndrome
#13
Kemal Tekin, Mehmet Ali Sekeroglu, Hasan Kiziltoprak, Esat Yetkin, Sibel Doguizi, Pelin Yilmazbas
PURPOSE: To perform a comparison of static and dynamic pupillometry measurements in patients with clinically unilateral pseudoexfoliation syndrome (PES) and age-matched controls. METHODS: This prospective cross-sectional study consisted of 38 patients with unilateral PES and 40 control participants. A quantitative pupillometry system was used to evaluate the pupil characteristics of eyes with PES (Group 1), clinically unaffected fellow eyes (Group 2), and healthy eyes (Group 3)...
March 23, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29560355/limitations-of-using-il-17a-and-ifn-%C3%AE-induced-protein-10-to-detect-bovine-tuberculosis
#14
Ting Xin, Xintao Gao, Hongjun Yang, Pingjun Li, Qianqian Liang, Shaohua Hou, Xiukun Sui, Xiaoyu Guo, Weifeng Yuan, Hongfei Zhu, Jiabo Ding, Hong Jia
Bovine tuberculosis (bTB) is primarily caused by infection with Mycobacterium bovis , which belongs to the Mycobacterium tuberculosis complex. The airborne route is considered the most common for transmission of M. bovis , and more than 15% of cattle with bTB shed the Mycobacterium , which can be detect by nested PCR to amplify mycobacterial mpb 70 from a nasal swab from a cow. To screen for cytokines fostering early and accurate detection of bTB, peripheral blood mononuclear cells were isolated from naturally M...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29559126/biophysical-and-immunological-characterization-of-the-esx-4-system-esat-6-family-proteins-rv3444c-and-rv3445c-from-mycobacterium-tuberculosis-h37rv
#15
Himanshu Pandey, Farheen Fatma, Shivraj M Yabaji, Meera Kumari, Sarita Tripathi, Kanchan Srivastava, Dinesh K Tripathi, Surya Kant, Kishore K Srivastava, Ashish Arora
The ESAT-6 family proteins of Mycobacterium tuberculosis are regarded as the key mediators in mycobacterial virulence and are largely considered as antigens that can improve TB vaccines and diagnostics. We have characterized Rv3444c and Rv3445c proteins of the ESX-4 system of ESAT-6 family of M. tuberculosis H37Rv, and have experimentally established that these two proteins interact to form a heterodimeric complex. Complex formation resulted in induction of α-helical conformation and stability against chemical denaturation...
March 2018: Tuberculosis
https://www.readbyqxmd.com/read/29555701/esx-paralogs-are-functionally-equivalent-to-esx-1-proteins-but-are-dispensable-for-virulence-in-m-marinum
#16
Rachel E Bosserman, Cristal Reyna Thompson, Kathleen R Nicholson, Patricia A Champion
Mycobacterium marinum is a non-tuberculous pathogen of poikilothermic fish and an opportunistic human pathogen. Like tuberculous mycobacteria, the M. marinum M strain requires the ESX-1 (ESAT-6 System 1) secretion system for virulence in host cells. EsxB and EsxA, two major virulence factors exported by the ESX-1 system, are encoded by the esxBA genes within the ESX-1 locus. Deletion of the esxBA genes abrogates ESX-1 export and attenuates M. marinum in ex vivo and in vivo models of infection. Interestingly, there are several duplications of the esxB and esxA genes ( esxB_1, esxB_2, esxA_1 , esxA_2, and esxA_3 ) in the M...
March 19, 2018: Journal of Bacteriology
https://www.readbyqxmd.com/read/29554517/characterization-of-gait-using-plantar-force-transfer-trajectory-in-individuals-with-hallux-valgus-deformity
#17
Saba Eshraghi, Ibrahim Esat, Amir A Mohagheghi
BACKGROUND: Hallux Valgus (HV) is the most common fore-foot deformity, which causes foot pain and limited motion that are encountered in podiatric and orthopedic practices. The purpose of this study is to develop a reliable pattern recognition method to identify the presence of HV based on plantar force measurements. METHOD: Forces at five discrete metatarsal regions are measured at discrete time intervals under the right foot. Under this method, it is hypothesized that force measurement at a given time interval is related to the forces at a previous time interval by using Markovian transition matrix (T matrix)...
March 11, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29551901/a-national-multicenter-non-interventional-observational-study-on-treatment-patterns-in-patients-with-metastatic-renal-cell-carcinoma-in-turkey-notes-study
#18
Şuayib Yalçın, Ramazan Yildiz, Faysal Dane, Aziz Karaoğlu, Berna Öksüzoğlu, Özgür Özyılkan, Alper Sevinç, Feyyaz Özdemir, Hande Turna, Rüçhan Uslu, Esat Ulay
Introduction: The introduction of targeted therapies in renal cell carcinoma has significantly improved its prognosis and treatment outcomes in recent years. Such treatment options are targeted therapies of the vascular endothelial growth factor (VEGF) pathway and the mammalian target of the rapamycin pathway. With the use of tyrosine kinase inhibitors (TKIs) and mammalian target of the rapamycin inhibitors, overall survival has increased up to 2 years. In Turkey, due to applicable reimbursement conditions for patients with metastatic renal cell carcinoma (mRCC), interferon use is mandated as a first-line treatment, thus providing information on the use of everolimus only after initial interferon and second-line VEGF-targeted treatments such as VEGF-TKI...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29551459/unilateral-deep-brain-stimulation-suppresses-alpha-and-beta-oscillations-in-sensorimotor-cortices
#19
Omid Abbasi, Jan Hirschmann, Lena Storzer, Tolga Esat Özkurt, Saskia Elben, Jan Vesper, Lars Wojtecki, Georg Schmitz, Alfons Schnitzler, Markus Butz
Deep brain stimulation (DBS) is an established therapy to treat motor symptoms in movement disorders such as Parkinson's disease (PD). The mechanisms leading to the high therapeutic effectiveness of DBS are poorly understood so far, but modulation of oscillatory activity is likely to play an important role. Thus, investigating the effect of DBS on cortical oscillatory activity can help clarifying the neurophysiological mechanisms of DBS. Here, we aimed at scrutinizing changes of cortical oscillatory activity by DBS at different frequencies using magnetoencephalography (MEG)...
March 16, 2018: NeuroImage
https://www.readbyqxmd.com/read/29546381/human-immunodeficiency-virus-infection-impairs-th1-and-th17-mycobacterium-tuberculosis-specific-t-cell-responses
#20
Lyle W Murray, Iman Satti, Jodi Meyerowitz, Matthew Jones, Christian B Willberg, James E Ussher, Dominique Goedhals, Jacob Hurst, Rodney E Phillips, Helen McShane, Cloete van Vuuren, John Frater
Background: Human immunodeficiency virus (HIV)-infected individuals have a higher risk of developing active tuberculosis (TB) than HIV-uninfected individuals, but the mechanisms underpinning this are unclear. We hypothesized that depletion of specific components of Mycobacterium tuberculosis (Mtb)-specific CD4+ and CD8+ T-cell responses contributed to this increased risk. Methods: Mtb-specific T-cell responses in 147 HIV-infected and 44 HIV-uninfected control subjects in a TB-endemic setting in Bloemfontein, South Africa, were evaluated...
May 5, 2018: Journal of Infectious Diseases
keyword
keyword
26449
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"