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https://www.readbyqxmd.com/read/28936190/oxytocin-and-opioid-receptor-gene-polymorphisms-associated-with-greeting-behavior-in-dogs
#1
Enikő Kubinyi, Melinda Bence, Dora Koller, Michele Wan, Eniko Pergel, Zsolt Ronai, Maria Sasvari-Szekely, Ádám Miklósi
Meeting humans is an everyday experience for most companion dogs, and their behavior in these situations and its genetic background is of major interest. Previous research in our laboratory reported that in German shepherd dogs the lack of G allele, and in Border collies the lack of A allele, of the oxytocin receptor gene (OXTR) 19208A/G single nucleotide polymorphism (SNP) was linked to increased friendliness, which suggests that although broad traits are affected by genetic variability, the specific links between alleles and behavioral variables might be breed-specific...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28933959/what-makes-a-dog-adoptable-an-eye-tracking-investigation
#2
Sara Isgate, Justin J Couchman
Humans readily attribute personality and behavioral traits to dogs, and these attributions influence decisions about adoption. This study focused on how these attributions could be influenced by breed and pose by using pictures of four breeds (Doberman Pinscher, Golden Retriever, pit bull, and Rottweiler) in 4 poses (dog sitting alone, sitting with a human, standing alone, and walking on a leash with a human). Participants rated each picture on friendliness, aggressiveness, and adoptability. Eye-tracking technology identified which specific features were represented in each picture to determine whether they had any effect on the judgments...
September 21, 2017: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/28929104/increased-serum-and-urinary-oxytocin-concentrations-after-nasal-administration-in-beagle-dogs
#3
Andrea Temesi, Julianna Thuróczy, Lajos Balogh, Ádám Miklósi
In recent years more and more studies have revealed the effect of extraneous oxytocin on the social behavior of dogs. The distribution of administered oxytocin in different physiologically relevant compartments is important because this knowledge forms the basis for the timing of behavior tests after the administration. Most behavioral studies rely on the non-invasive intranasal application of oxytocin. The aim of this study was to determine the time course of intranasal administered oxytocin secretion into blood and urine and also establish a connection between intranasal received oxytocin and urinary cortisol in dogs...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28919678/cortisol-concentration-pain-and-sedation-scale-in-free-roaming-dogs-treated-with-carprofen-after-ovariohysterectomy
#4
Katarina Nenadović, Marijana Vučinić, Brana Radenković-Damnjanović, Ljiljana Janković, Radislava Teodorović, Eva Voslarova, Zsolt Becskei
BACKGROUND AND AIM: One of the topic issues in animal welfare activities is the free roaming dog welfare especially in developing countries such as Serbia. The way of controlling population of free roaming dogs is their reproduction with the method of "Catch-Neuter-Release." This complex process consists of capturing free roaming dogs in public areas, sterilizing, and returning them to the public area from which they were temporarily removed. Ovariohysterectomy present the period with a high intensity of stress reaction since many veterinarians in Serbia do not use analgesia for this group of dogs...
August 2017: Veterinary World
https://www.readbyqxmd.com/read/28913340/caregiver-reports-of-interactions-between-children-up-to-6-years-and-their-family-dog-implications-for-dog-bite-prevention
#5
Christine Arhant, Andrea Martina Beetz, Josef Troxler
In children up to 6 years, interactions such as interfering with the dog's resources and also benign behaviors (e.g., petting) commonly precede a bite incident with the family dog. Therefore, the aim of the present study was to explore the development of everyday interactions between children up to 6 years and their family dogs and whether parents' attitudes to supervision are related to those interactions. Additionally, we investigated whether behavior of dogs that had lived in the family for longer than the child differed from those that grew up with children...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28895076/new-botanical-anxiolytics-for-use-in-companion-animals-and-humans
#6
Rui Liu, Fida Ahmed, Christian Cayer, Martha Mullally, Ana Francis Carballo, Marco Otarola Rojas, Mario Garcia, John Baker, Aleksandar Masic, Pablo E Sanchez, Luis Poveda, Zul Merali, Tony Durst, John T Arnason
As part of our ongoing research into botanical therapies for anxiety disorders, the neotropical vine Souroubea sympetala was chosen for study as a phytochemical discovery strategy focusing on rare Central American plant families. When orally administered to male Sprague-Dawley rats, the crude plant extract, its ethyl acetate fraction, supercritical carbon dioxide fraction, or its isolated triterpenes reduced anxiety and/or fear-related behavior in standardized behavioral models. Pharmacological studies showed that the extracts acted at the benzodiazepine GABAA receptor and reduced corticosterone levels...
September 11, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28878428/elimination-of-guinea-worm-disease-in-ethiopia-current-status-of-the-disease-s-eradication-strategies-and-challenges-to-the-end-game
#7
Habtamu Bedimo Beyene, Abyot Bekele, Amanu Shifara, Yehenew A Ebstie, Zelalem Desalegn, Zeyede Kebede, Abate Mulugeta, Kebede Deribe, Zerihun Tadesse, Tamrat Abebe, Biruck Kebede, Getaneh Abrha, Daddi Jima
Dracunculiasis, also named Guinea Worm Disease (GWD), is one of the Neglected Tropical Diseases (NTDs) caused by a parasitic nematode known as Dracunculus medinensis and has been known since antiquity as 'fiery serpent' from Israelites. It is transmitted to humans via drinking contaminated water containing infective copepods. Given, its feasibility for eradication, the Guinea Worm Eradication Program (GWEP) was launched in 1980 with the aim of eradicating the disease. Since its inception, GWEP has made an extraordinary progress in interrupting transmission...
2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/28875568/gene-expression-of-matrix-metalloproteinases-and-their-inhibitors-timps-in-meningiomas-of-dogs
#8
M T Mandara, A Reginato, G Foiani, S De Luca, G Guelfi
BACKGROUND: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) are considered to be key mediators of tumor invasion and metastasis. MMP-2 and MMP-9 are expressed in meningiomas of dogs, but TIMP expression, and variations of specific MMP/TIMP ratios still are unknown in this tumor. HYPOTHESIS/OBJECTIVES: Expression of MMP/TIMP might increase progressively from grade I to grade III meningioma. Therefore, genetic expression of MMP-2 and MMP-9, and specific TIMP-2 and TIMP-1, respectively, has been investigated in meningiomas of different grades...
September 5, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28865986/validation-of-salivary-oxytocin-and-vasopressin-as-biomarkers-in-domestic-dogs
#9
Evan L MacLean, Laurence R Gesquiere, Nancy Gee, Kerinne Levy, W Lance Martin, C Sue Carter
BACKGROUND: Oxytocin (OT) and Vasopressin (AVP) are phylogenetically conserved neuropeptides with effects on social behavior, cognition and stress responses. Although OT and AVP are most commonly measured in blood, urine and cerebrospinal fluid (CSF), these approaches present an array of challenges including concerns related to the invasiveness of sample collection, the potential for matrix interference in immunoassays, and whether samples can be collected at precise time points to assess event-linked endocrine responses...
August 30, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28857544/identification-of-5-1-methyl-5-trifluoromethyl-1h-pyrazol-3-yl-thiophene-2-carboxamides-as-novel-and-selective-monoamine-oxidase-b-inhibitors-used-to-improve-memory-and-cognition
#10
Alan P Kaplan, Terence Keenan, Roderick Scott, Xianbo Zhou, Rusiko Bourchouladze, Andrew J McRiner, Mark E Wilson, Darlene Romashko, Regina Miller, Matthew Bletsch, Gary Anderson, Jennifer Stanley, Adia Zhang, Dong Lee, John Nikpur
Initial work in Drosophila and mice demonstrated that the transcription factor cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) is a master control gene for memory formation. The relationship between CREB and memory has also been found to be true in other species, including aplysia and rats. It is thus well-established that CREB activation plays a central role in memory enhancement and that CREB is activated during memory formation. On the basis of these findings, a phenotypic high-throughput screening campaign utilizing a CRE-luciferase (CRE-Luci) SK-N-MC cell line was performed to identify compounds that enhance transcriptional activation of the CRE promoter with a suboptimal dose of forskolin...
September 20, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28834400/cryopreservation-of-canine-cardiosphere-derived-cells-implications-for-clinical-application
#11
Luke C Dutton, Sophie A V Church, Hannah Hodgkiss-Geere, Brian Catchpole, Anthony Huggins, Jayesh Dudhia, David J Connolly
The clinical application of cardiosphere-derived cells (CDCs) to treat cardiac disease has gained increasing interest over the past decade. Recent clinical trials confirm their regenerative capabilities, although much remains to be elucidated about their basic biology. To develop this new treatment modality, in a cost effective and standardized workflow, necessitates the creation of cryopreserved cell lines to facilitate access for cardiac patients requiring urgent therapy. Cryopreservation may however lead to alterations in cell behavior and potency...
August 22, 2017: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
https://www.readbyqxmd.com/read/28829389/-you-think-you-re-helping-them-but-they-re-helping-you-too-experiences-of-scottish-male-young-offenders-participating-in-a-dog-training-program
#12
Rebecca J Leonardi, Hannah M Buchanan-Smith, Gill McIvor, Sarah-Jane Vick
Interaction with animals can be beneficial to humans and animal-assisted interventions (AAIs) are increasingly popular in a range of contexts. Dog training programs (DTPs) are the most popular form of AAI in custodial contexts; prisoners often have multiple needs and DTPs seem to facilitate a diverse range of positive outcomes, including improvements in well-being, behavior, and offending behavior. However, evidence on the efficacy of prison-based DTPs is still limited and these evaluations often lack detail or methodological rigor...
August 22, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28822004/in-vitro-validation-of-the-hippo-pathway-as-a-pharmacological-target-for-canine-mammary-gland-tumors
#13
Samantha Guillemette, Charlène Rico, Philippe Godin, Derek Boerboom, Marilène Paquet
Canine mammary tumors (CMTs) are the most common neoplasms in intact female dogs. Some clinical and molecular similarities between certain CMT subtypes and breast cancer make them a potential model for the study of the human disease. As misregulated Hippo signaling is thought to play an important role in breast cancer development and also occurs in CMTs, we sought to determine if Hippo represents a valid pharmacological target for the treatment of CMTs. Six CMT cell lines were assessed for their expression of the Hippo pathway effectors YAP and TAZ and for their sensitivity to verteporfin, an inhibitor of YAP-mediated transcriptional coactivation...
August 18, 2017: Journal of Mammary Gland Biology and Neoplasia
https://www.readbyqxmd.com/read/28819088/lissencephaly-in-a-pekingese
#14
Genya Shimbo, Michihito Tagawa, Eiji Oohashi, Masashi Yanagawa, Kazuro Miyahara
A 1-year-old neutered male Pekingese was presented for evaluation and further treatment of cluster seizures. The dog had behavioral abnormalities, and a prosencephalic lesion was suspected following neurological examination. The dog showed signs of learning difficulty. Magnetic resonance imaging of the brain revealed a remarkably smooth cerebral cortex with a reduced number of gyri, as well as a cystic lesion associated with the quadrigeminal cistern. A diagnosis of lissencephaly, concurrent with a quadrigeminal cisternal cyst, was made...
August 17, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28804710/application-of-survival-analysis-and-multistate-modeling-to-understand-animal-behavior-examples-from-guide-dogs
#15
Lucy Asher, Naomi D Harvey, Martin Green, Gary C W England
Epidemiology is the study of patterns of health-related states or events in populations. Statistical models developed for epidemiology could be usefully applied to behavioral states or events. The aim of this study is to present the application of epidemiological statistics to understand animal behavior where discrete outcomes are of interest, using data from guide dogs to illustrate. Specifically, survival analysis and multistate modeling are applied to data on guide dogs comparing dogs that completed training and qualified as a guide dog, to those that were withdrawn from the training program...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/28803893/the-companion-dog-as-a-unique-translation-model-for-aging
#16
REVIEW
Andrea Mazzatenta, Camillo Di Giulio, Domenico Robbe, Augusto Carluccio, Alessandro Cellerino
The dog is a unique species due to its wide variation among breeds in size, morphology, behavior and lifespan coupled with a genetic structure that facilitates the dissection of the genetic architecture controlling those traits. Dogs and humans coevolved and share recent evolutionary selection processes like, for example, adaptations to digest starch-rich diets. Many diseases of the dog have a human counterpart, notably Alzheimer's that is otherwise difficult to model in other organisms. Unlike laboratory animals, companion dogs share the human environment and lifestyle, are exposed to the same pollutants and are faced with pathogens and infections...
August 10, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28797909/smelling-themselves-dogs-investigate-their-own-odours-longer-when-modified-in-an-olfactory-mirror-test
#17
Alexandra Horowitz
While domestic dogs, Canis familiaris, have been found to be skillful at social cognitive tasks and even some meta-cognitive tasks, they have not passed the test of mirror self-recognition (MSR). Acknowledging the motivational and sensory challenges that might hinder performance, even before the question of self-recognition is broached, this study creates and enacts a novel design extrapolated from the species' natural behaviour. Given dogs' use of olfactory signals in communication, this experiment presents dogs with various canisters for approach and investigation...
October 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28795025/sub-chronic-safety-evaluation-of-aqueous-extract-of-alangium-salvifolium-l-f-wangerin-leaves-in-rats
#18
Bhupinder Kapoor, Gagandeep Kaur, Mukta Gupta, Reena Gupta
Conventionally, the juice and extract of Alangium salvifolium leaves have been used for the treatment of diabetes, wound healing, dog bite, and as a poultice in rheumatism. To carry out the sub-chronic toxicity and thereafter safety evaluation of A. salvifolium leaves. The aqueous extract of A. salvifolium leaves was administered orally at the doses of 200, 400, and 800 mg/kg/day for 90 days. All the animals were observed daily for general behavior, changes in body weight, food, and water consumption. At the end of the treatment period, biochemical and hematological parameters were analyzed; and the animals were sacrificed for histopathological examination of heart, lungs, liver, and kidney...
July 2017: Journal of Advanced Pharmaceutical Technology & Research
https://www.readbyqxmd.com/read/28792799/investigating-associations-between-proliferation-indices-c-kit-and-lymph-node-stage-in-canine-mast-cell-tumors
#19
Erika Lauren Krick, Matti Kiupel, Amy C Durham, Tuddow Thaiwong, Dorothy C Brown, Karin U Sorenmo
Previous studies have evaluated cellular proliferation indices, KIT expression, and c-kit mutations to predict the clinical behavior of canine mast cell tumors (MCTs). The study purpose was to retrospectively compare mitotic index, argyrophilic nucleolar organizer regions (AgNORs)/nucleus, Ki-67 index, KIT labeling pattern, and internal tandem duplication mutations in c-KIT between stage I and stage II grade II MCTs. Medical records and tumor biopsy samples from dogs with Grade II MCTs with cytological or histopathological regional lymph node evaluation were included...
August 9, 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28776031/structural-variants-in-genes-associated-with-human-williams-beuren-syndrome-underlie-stereotypical-hypersociability-in-domestic-dogs
#20
Bridgett M vonHoldt, Emily Shuldiner, Ilana Janowitz Koch, Rebecca Y Kartzinel, Andrew Hogan, Lauren Brubaker, Shelby Wanser, Daniel Stahler, Clive D L Wynne, Elaine A Ostrander, Janet S Sinsheimer, Monique A R Udell
Although considerable progress has been made in understanding the genetic basis of morphologic traits (for example, body size and coat color) in dogs and wolves, the genetic basis of their behavioral divergence is poorly understood. An integrative approach using both behavioral and genetic data is required to understand the molecular underpinnings of the various behavioral characteristics associated with domestication. We analyze a 5-Mb genomic region on chromosome 6 previously found to be under positive selection in domestic dog breeds...
July 2017: Science Advances
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