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https://www.readbyqxmd.com/read/28327184/catestatin-vasostatin-cortisol-and-pain-assessments-in-dogs-suffering-from-traumatic-bone-fractures
#1
Thanikul Srithunyarat, Ragnvi Hagman, Odd V Höglund, Mats Stridsberg, Ulf Olsson, Jeanette Hanson, Chalermkwan Nonthakotr, Anne-Sofie Lagerstedt, Ann Pettersson
BACKGROUND: Traumatic bone fractures cause moderate to severe pain, which needs to be minimized for optimal recovery and animal welfare, illustrating the need for reliable objective pain biomarkers for use in a clinical setting. The objectives of this study were to investigate catestatin (CST) and vasostatin (VS) concentrations as two new potential biomarkers, and cortisol concentrations, scores of the short form of the Glasgow composite measure pain scale (CMPS-SF), and visual analog scale (VAS) in dogs suffering from traumatic bone fractures before and after morphine administration in comparison with healthy dogs...
March 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28321510/dna-methylation-patterns-of-behavior-related-gene-promoter-regions-dissect-the-gray-wolf-from-domestic-dog-breeds
#2
Zsofia Banlaki, Giulia Cimarelli, Zsofia Viranyi, Eniko Kubinyi, Maria Sasvari-Szekely, Zsolt Ronai
A growing body of evidence highlights the relationship between epigenetics, especially DNA methylation, and population divergence as well as speciation. However, little is known about how general the phenomenon of epigenetics-wise separation of different populations is, or whether population assignment is, possible based on solely epigenetic marks. In the present study, we compared DNA methylation profiles between four different canine populations: three domestic dog breeds and their ancestor the gray wolf...
March 21, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28306133/injection-of-toll-like-receptor-4-sirna-into-the-ventrolateral-periaqueductal-gray-attenuates-withdrawal-syndrome-in-morphine-dependent-rats
#3
Q F Liu, L Li, Y Q Guo, X Li, Z D Mou, X Wang, G Z Du
We assessed the role of the Toll-like receptor 4 (TLR4) gene in the ventrolateral periaqueductal gray (vlPAG) region of morphine-dependent rats on attenuating withdrawal syndrome, and regulating glutamic acid decarboxylase (GAD67), glutamic acid (Glu), and gamma-aminobutyric acid (GABA). After siRNA-mediated downregulation of TLR4, changes were observed in withdrawal behavior and downstream signaling molecules. Rats were injected into the vlPAG with TLR4 siRNA, followed by intraperitoneal injection of morphine for 5 consecutive days, and then naloxone, and the behavioral indices of morphine withdrawal were observed...
December 1, 2016: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/28293204/what-are-the-ingredients-for-an-inequity-paradigm-manipulating-the-experimenter-s-involvement-in-an-inequity-task-with-dogs
#4
Désirée Brucks, Sarah Marshall-Pescini, Jennifer L Essler, Jim McGetrick, Ludwig Huber, Friederike Range
Cooperation is only beneficial if the outcome is equally shared between individuals involved in the cooperative interaction. A mechanism to limit the development of unequal cooperation is inequity aversion, the negative reaction to unequal treatment. While inequity aversion has been studied extensively across many animal species, it remains unclear whether inequity aversion elicited in experimental settings is directed to the cooperative partner animal or rather to the experimenter distributing the rewards unequally...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28287754/characterizing-autism-relevant-social-behavior-in-poodles-via-owner-report
#5
Rachel M Zamzow, Lisa Lit, Shelley Hamilton, David Q Beversdorf
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social communication and the presence of restricted, repetitive behaviors. It can be difficult to model the complex behavioral features of this disorder with rodent models, which have limited similarity to human behaviors. The domestic dog may be a promising model of complex human behavior, including core features of ASD. The present study examines ASD-relevant social behavior in Miniature and Standard Poodles using an owner-report questionnaire with questions adapted from the Autism Diagnostic Observation Schedule (Lord, Rutter, DiLavore, & Risi, 2000)...
March 13, 2017: Journal of Comparative Psychology
https://www.readbyqxmd.com/read/28282235/artifacts-during-short-term-interictal-electroencephalographic-recording-in-dogs
#6
Alberto Cauduro, Maurizio Dondi, Paolo Favole, Mauro Opreni, Lucia Antonietta Simonetto, Valentina Lorenzo
The electroencephalogram (EEG) is an electrodiagnostic technique widely used in both scientific research and clinical medicine. It makes it possible to study the neurophysiology of brain activity by recording real-time changes in electrical potential produced by cortical activation. The importance of EEG in diagnosing canine epilepsy demonstrates its usefulness when the owner's description of crises is not clear or when the episodes cannot be differentiated from behavioral or cardiac disorders. However, EEG recordings also often record electrical activity from sources other than the brain, which may interfere with the clinical event-related signal...
March 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28266550/functional-mri-in-awake-dogs-predicts-suitability-for-assistance-work
#7
Gregory S Berns, Andrew M Brooks, Mark Spivak, Kerinne Levy
The overall goal of this work was to measure the efficacy of fMRI for predicting whether a dog would be a successful service dog. The training and imaging were performed in 49 dogs entering service training at 17-21 months of age. 33 dogs completed service training and were matched with a person, while 10 were released for behavioral reasons (4 were selected as breeders and 2 were released for medical reasons.) After 2 months of training, fMRI responses were measured while each dog observed hand signals indicating either reward or no reward and given by both a familiar handler and a stranger...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28266316/genomic-copy-number-variation-associated-with-clinical-outcome-in-canine-cutaneous-mast-cell-tumors
#8
Paulo C Jark, Deborah B P Mundin, Marcio de Carvalho, Raquel B Ferioli, Letícia A Anai, Fabio A Marchi, Silvia R Rogatto, Renee Laufer-Amorim, Mirela Tinucci-Costa
Mast cell tumors are the most common malignant cutaneous tumors in dogs. Although there are several prognostic factors involved, the clinical and biological behavior of this type of tumor varies greatly, making the best choice of treatment challenging. Molecular techniques can be used to evaluate a large number of genes involved in the neoplastic process and aid in the selection of candidate genes related to prognostic and predicting factors. Identification of the genes associated with tumor development and progression can be performed through the analysis of numerical and structural changes in DNA isolated from tumor cells by array comparative genomic hybridization (aCGH)...
November 17, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/28265981/exploring-canine-human-differences-in-product-performance-part-ii-use-of-modeling-and-simulation-to-explore-the-impact-of-formulation-on-ciprofloxacin-in-vivo-absorption-and-dissolution-in-dogs
#9
M N Martinez, B Mistry, V Lukacova, K A Lentz, J E Polli, S W Hoag, T Dowling, R Kona, R M Fahmy
This study explored the in vivo performance of three oral ciprofloxacin formulations (oral solution, fast, or slow dissolving tablets) in beagle dogs. The in vivo absorption and dissolution behaviors, estimated with in silico mechanistic models, were compared to the results previously published in human volunteers. Six normal healthy male beagle dogs (five to completion) received three oral formulations and an intravenous infusion in a randomized crossover design. Plasma ciprofloxacin concentrations were estimated by tandem mass spectrometry detection...
March 6, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28263765/exogenous-testosterone-decreases-men-s-personal-distance-in-a-social-threat-context
#10
Lisa Wagels, Sina Radke, Katharina Sophia Goerlich, Ute Habel, Mikhail Votinov
BACKGROUND: Testosterone can motivate human approach and avoidance behavior. Specifically, the conscious recognition of and implicit reaction to angry facial expressions is influenced by testosterone. The study tested whether exogenous testosterone modulates the personal distance (PD) humans prefer in a social threat context. METHODS: 82 healthy male participants underwent either transdermal testosterone (testosterone group) or placebo application (placebo group)...
March 11, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28247440/clinical-features-imaging-characteristics-and-long-term-outcome-of-dogs-with-cranial-meningocele-or-meningoencephalocele
#11
K Lazzerini, R Gutierrez-Quintana, R José-López, F McConnell, R Gonçalves, J McMurrough, S De Decker, C Muir, S L Priestnall, L Mari, F Stabile, L De Risio, C Loeffler, A Tauro, C Rusbridge, S Rodenas, S Añor, C de la Fuente, A Fischer, A Bruehschwein, J Penderis, J Guevar
BACKGROUND: The term meningoencephalocele (MEC) describes a herniation of cerebral tissue and meninges through a defect in the cranium, whereas a meningocele (MC) is a herniation of the meninges alone. HYPOTHESIS/OBJECTIVES: To describe the clinical features, magnetic resonance imaging (MRI) characteristics, and outcomes of dogs with cranial MC and MEC. ANIMALS: Twenty-two client-owned dogs diagnosed with cranial MC or MEC. METHODS: Multicentric retrospective descriptive study...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28245980/assessment-of-domestic-cat-personality-as-perceived-by-416-owners-suggests-six-dimensions
#12
Pauleen C Bennett, Nicholas J Rutter, Jessica K Woodhead, Tiffani J Howell
Understanding individual behavioral differences in domestic cats could lead to improved selection when potential cat owners choose a pet with whom to share their lives, along with consequent improvements in cat welfare. Yet very few attempts have been made to elicit cat personality dimensions using the trait-based exploratory approaches applied previously, with some success, to humans and dogs. In this study, a list of over 200 adjectives used to describe cat personality was assembled. This list was refined by two focus groups...
February 27, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28243544/effects-of-shepherds-and-dogs-on-livestock-depredation-by-leopards-panthera-pardus-in-north-eastern-iran
#13
Igor Khorozyan, Mahmood Soofi, Mobin Soufi, Amirhossein Khaleghi Hamidi, Arash Ghoddousi, Matthias Waltert
Human-carnivore conflicts over livestock depredation are increasingly common, yet little is understood about the role of husbandry in conflict mitigation. As shepherds and guarding dogs are most commonly used to curb carnivore attacks on grazing livestock, evaluation and improvement of these practices becomes an important task. We addressed this issue by studying individual leopard (Panthera pardus) attacks on sheep and goats in 34 villages near Golestan National Park, Iran. We obtained and analyzed data on 39 attacks, which included a total loss of 31 sheep and 36 goats in 17 villages...
2017: PeerJ
https://www.readbyqxmd.com/read/28240398/standardization-of-a-videofluoroscopic-swallow-study-protocol-to-investigate-dysphagia-in-dogs
#14
R A Harris, M E Grobman, M J Allen, J Schachtel, N E Rawson, B Bennett, J Ledyayev, B Hopewell, J R Coates, C R Reinero, T E Lever
BACKGROUND: Videofluoroscopic swallow study (VFSS) is the gold standard for diagnosis of dysphagia in veterinary medicine but lacks standardized protocols that emulate physiologic feeding practices. Age impacts swallow function in humans but has not been evaluated by VFSS in dogs. HYPOTHESIS/OBJECTIVES: To develop a protocol with custom kennels designed to allow free-feeding of 3 optimized formulations of contrast media and diets that address limitations of current VFSS protocols...
March 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/28239365/characterizing-early-maternal-style-in-a-population-of-guide-dogs
#15
Emily E Bray, Mary D Sammel, Dorothy L Cheney, James A Serpell, Robert M Seyfarth
In both humans and non-humans, differences in maternal style during the first few weeks of life can be reliably characterized, and these differences affect offspring's temperament and cognition in later life. Drawing on the breeding population of dogs at The Seeing Eye, a guide dog school in Morristown, New Jersey, we conducted videotaped focal follows on 21 mothers and their litters (n = 138 puppies) over the first 3 weeks of the puppies' lives in an effort to characterize maternal style. We found that a mother's attitude and actions toward her offspring varied naturally between individuals, and that these variations could be summarized by a single principal component, which we described as Maternal behavior...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28238915/a-simply-prepared-small-diameter-artificial-blood-vessel-that-promotes-in-situ-endothelialization
#16
Hong-Feng Guo, Wei-Wei Dai, De-Hui Qian, Zhe-Xue Qin, Yan Lei, Xiao-Yu Hou, Can Wen
Synthetic grafts are of limited use in small-diameter vessels (Φ<6mm) due to the poor patency rate. The inability of such grafts to achieve early endothelialization together with the compliance mismatch between the grafts and the native vessels promote thrombosis, which eventually leads to graft occlusion. In the current study, stromal cell-derived factor (SDF)-1α/vascular endothelial growth factor (VEGF)-loaded polyurethane (PU) conduits were simply prepared via electrospinning. The mechanical property, drug release behavior and cytocompatibility of the conduits were investigated...
February 24, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28231248/intensive-trapping-of-blood-fed-anopheles-darlingi-in-amazonian-peru-reveals-unexpectedly-high-proportions-of-avian-blood-meals
#17
Marta Moreno, Marlon P Saavedra, Sara A Bickersmith, Catharine Prussing, Adrian Michalski, Carlos Tong Rios, Joseph M Vinetz, Jan E Conn
Anopheles darlingi, the main malaria vector in the Neotropics, has been considered to be highly anthropophilic. However, many behavioral aspects of this species remain unknown, such as the range of blood-meal sources. Barrier screens were used to collect resting Anopheles darlingi mosquitoes from 2013 to 2015 in three riverine localities (Lupuna, Cahuide and Santa Emilia) in Amazonian Peru. Overall, the Human Blood Index (HBI) ranged from 0.58-0.87, with no significant variation among years or sites. Blood-meal analysis revealed that humans are the most common blood source, followed by avian hosts (Galliformes-chickens and turkeys), and human/Galliforme mixed-meals...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28222769/plasticity-of-host-selection-by-malaria-vectors-of-papua-new-guinea
#18
John B Keven, Lisa Reimer, Michelle Katusele, Gussy Koimbu, Rebecca Vinit, Naomi Vincent, Edward Thomsen, David R Foran, Peter A Zimmerman, Edward D Walker
BACKGROUND: Host selection is an important determinant of vectorial capacity because malaria transmission increases when mosquitoes feed more on humans than non-humans. Host selection also affects the outcome of long-lasting insecticidal nets (LLIN). Despite the recent nationwide implementation of LLIN-based malaria control program in Papua New Guinea (PNG), little is known about the host selection of the local Anopheles vectors. This study investigated the host selection of Anopheles vectors in PNG...
February 21, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28202716/pattern-separation-and-goal-directed-behavior-in-the-aged-canine
#19
Shikha Snigdha, Michael A Yassa, Christina deRivera, Norton W Milgram, Carl W Cotman
The pattern separation task has recently emerged as a behavioral model of hippocampus function and has been used in several pharmaceutical trials. The canine is a useful model to evaluate a multitude of hippocampal-dependent cognitive tasks that parallel those in humans. Thus, this study was designed to evaluate the suitability of pattern separation task(s) for detecting age-related changes in canines. We also assessed the dogs' ability to show pattern separation and discrimination reversal, which provides a novel extension of the pattern separation learning literature...
March 2017: Learning & Memory
https://www.readbyqxmd.com/read/28182485/-wolves-canis-lupus-and-dogs-canis-familiaris-differ-in-following-human-gaze-into-distant-space-but-respond-similar-to-their-packmates-gaze-correction-to-werhahn-et-al-2016
#20
(no author information available yet)
Reports an error in "Wolves (Canis lupus) and dogs (Canis familiaris) differ in following human gaze into distant space but respond similar to their packmates' gaze" by Geraldine Werhahn, Zsófia Virányi, Gabriela Barrera, Andrea Sommese and Friederike Range (Journal of Comparative Psychology, 2016[Aug], Vol 130[3], 288-298). In the article, the affiliations for the second and fifth authors should be Wolf Science Center, Ernstbrunn, Austria, and Comparative Cognition, Messerli Research Institute, University of Veterinary Medicine Vienna/ Medical University of Vienna/University of Vienna...
February 2017: Journal of Comparative Psychology
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