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https://www.readbyqxmd.com/read/29785888/the-impact-of-oprm1-s-genetic-polymorphisms-on-methadone-maintenance-treatment-in-opioid-addicts-a-systematic-review
#1
Bilel Oueslati, Olfa Moula, Rim Ghachem
AIM: Methadone is a long-acting opioid receptor agonist. It is prescribed to patients with opioid-related use disorders. The OPRM1 gene encodes for methadone's main receptor. It appears that polymorphisms in OPRM1 may affect the efficacy of methadone maintenance treatment (MMT). OBJECTIVE: Our purpose was to identify all relevant published papers dealing with the impact ofOPRM1's SNPs  on MMT's efficacy and to summarize results in order to evaluate the relevance of conducting pretherapeutic genotyping in opioid addicts prior to the onset of MMT...
May 22, 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29771142/the-development-of-a-mouse-model-of-mtbi-induced-post-traumatic-migraine-and-identification-of-the-delta-opioid-receptor-as-a-novel-therapeutic-target
#2
Laura S Moye, Madeline L Novack, Alycia F Tipton, Harish Krishnan, Subhash C Pandey, Amynah Aa Pradhan
Background Post-traumatic headache is the most common and long-lasting impairment observed following mild traumatic brain injury, and frequently has migraine-like characteristics. The mechanisms underlying progression from mild traumatic brain injury to post-traumatic headache are not fully understood. The aim of this study was to develop a mouse model of post-traumatic headache and identify mechanisms and novel targets associated with this disorder. Methods We combined the closed head weight-drop method and the nitroglycerin chronic migraine model...
January 1, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/29706406/parental-overcontrol-x-oprm1-genotype-interaction-predicts-school-aged-children-s-sympathetic-nervous-system-activation-in-response-to-performance-challenge
#3
Lindsey C Partington, Jessica L Borelli, Patricia Smiley, Ella Jarvik, Hannah F Rasmussen, Lauren C Seaman, Erika L Nurmi
Parental overcontrol (OC), the excessive regulation of a child's behavior, cognition, and emotion, is associated with the development of child anxiety. While studies have shown that genetic factors may increase sensitivity to stress, genetic vulnerability to parental OC has not been examined in anxiety etiology. A functional polymorphism in the mu opioid receptor OPRM1 (A118G, rs1799971) has been shown to impact stress reactivity. Using a community sample of children (N = 85, 9-12 years old), we examined the main and interactive effects of maternal OC and child OPRM1 genotype in predicting children's sympathetic nervous system reactivity during a performance stressor...
April 26, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29705271/effects-of-human-sult1a3-sult1a4-genetic-polymorphisms-on-the-sulfation-of-acetaminophen-and-opioid-drugs-by-the-cytosolic-sulfotransferase-sult1a3
#4
Ahsan F Bairam, Mohammed I Rasool, Fatemah A Alherz, Maryam S Abunnaja, Amal A El Daibani, Katsuhisa Kurogi, Ming-Cheh Liu
Sulfoconjugation has been shown to be critically involved in the metabolism of acetaminophen (APAP), morphine, tapentadol and O-desmethyl tramadol (O-DMT). The objective of this study was to investigate the effects of single nucleotide polymorphisms (SNPs) of human SULT1A3 and SULT1A4 genes on the sulfating activity of SULT1A3 allozymes toward these analgesic compounds. Twelve non-synonymous coding SNPs (cSNPs) of SULT1A3/SULT1A4 were investigated, and the corresponding cDNAs were generated by site-directed mutagenesis...
April 26, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29704143/sufentanil-alleviates-intrathecal-lidocaine-induced-prolonged-sensory-and-motor-impairments-but-not-the-spinal-histological-injury-in-rats
#5
Zhong Zhang, Yuan Chen, E Wang, Lei Wu, Ruike Wang, Zongbin Song, Yingqi Weng, Zhihua Sun, Qulian Guo, Yunping Li
Spinal anesthesia has evolved into a safe and widely accepted method of anesthesia. Synergy between opioids and local anesthetics further increases the quality of analgesia and decreases the dose requirement of both local anesthetics and opioids. However, over the last decades compelling evidence suggested that lidocaine could be more neurotoxic than other commonly used local anesthetics. Whether opioids can modify the local anesthetics-induced neurotoxicity is largely unexplored. Here, we investigated the effect of sufentanil on the neurotoxicity induced by intrathecal lidocaine in a rat model...
April 27, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29695491/nest-box-exploration-may-stimulate-breeding-physiology-and-alter-mrna-expression-in-the-medial-preoptic-area-of-female-european-starlings
#6
Jeremy A Spool, Melannie D Jay, Lauren V Riters
Environmental resources are proposed to fine-tune the timing of breeding, yet how they may do so remains unclear. In female European starlings ( Sturnus vulgaris ), nest cavities are limited resources that are necessary for breeding. Females that explore nest cavities, compared to those that do not, readily perform sexually-motivated behaviors. We assigned female starlings to aviaries with 1) no nest boxes, 2) nest boxes, or 3) nest boxes, plants, flowing water, insects and berries to test the hypothesis that environmental resources alter neural systems to stimulate mating behavior...
April 25, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29678771/prenatal-ethanol-induces-an-anxiety-phenotype-and-alters-expression-of-dynorphin-nociceptin-orphanin-fq-genes
#7
Aranza Wille-Bille, Roberto Sebastián Miranda-Morales, Mariangela Pucci, Fabio Bellia, Claudio D'Addario, Ricardo Marcos Pautassi
Animal models have suggested that prenatal ethanol exposure (PEE) alters the κ opioid receptor system. The present study investigated the brain expression of dynorphin and nociceptin/orphanin FQ related genes and assessed anxiety-like behavior in the light-dark box (LDB), shelter-seeking and risk-taking behaviors in the concentric square field (CSF) test, and ethanol-induced locomotion in the open field (OF), in infant or adolescent Wistar rats that were exposed to PEE (0.0 or 2.0 g/kg, intragastrically, gestational days 17-20)...
April 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29667742/genetic-association-and-expression-analyses-of-the-phosphatidylinositol-4-phosphate-5-kinase-pip5k1c-gene-in-alcohol-use-disorder-relevance-for-pain-signaling-and-alcohol-use
#8
Ji Soo Lee, Jill L Sorcher, Allison D Rosen, Ruslan Damadzic, Hui Sun, Melanie Schwandt, Markus Heilig, John Kelly, Kelsey L Mauro, Audrey Luo, Daniel Rosoff, Christine Muench, Jeesun Jung, Zachary A Kaminsky, Falk W Lohoff
BACKGROUND: The gene encoding Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) has been recently implicated in pain regulation. Interestingly, a recent cross-tissue and cross-phenotypic epigenetic analysis identified the same gene in alcohol use disorder (AUD). Given the high comorbidity between AUD and chronic pain, we hypothesized that genetic variation in PIP5K1C might contribute to susceptibility to AUD. METHODS: We conducted a case-control association study of genetic variants in PIP5K1C...
April 18, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29649967/influence-of-maternal-and-own-genotype-at-tanning-dependence-related-snps-on-sun-exposure-in-childhood
#9
Jasmine Khouja, Sarah J Lewis, Carolina Bonilla
BACKGROUND: Research suggests there may be a genetic influence on the likelihood of becoming tanning dependent (TD). The way in which mothers regulate their children's sun exposure may be affected by being TD. We investigated the associations between single nucleotide polymorphisms (SNPs) related to being TD and early sun exposure. METHODS: Data from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used. Associations between 17 TD related SNPs in children and their mothers and 10 sun exposure variables in children (assessed via questionnaire at age 8) were analyzed in logistic and ordinal logistic regressions...
April 12, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29649030/resistin-is-a-novel-marker-for-postoperative-pain-intensity
#10
Jun Hozumi, Masahiko Sumitani, Daisuke Nishizawa, Makoto Nagashima, Kazutaka Ikeda, Hiroaki Abe, Ryoji Kato, Yoshiomi Kusakabe, Yoshitsugu Yamada
BACKGROUND: Pro- and anti-inflammatory cytokines (adipokines) associated with adipose tissue can modulate inflammatory processes and lead to systemic inflammatory conditions such as metabolic syndrome. In the present pilot study, we investigated 3 major adipokines (leptin, adiponectin, and resistin) and 2 nonspecific proinflammatory cytokines (tumor necrosis factor α and interleukin-6) with regard to their association with postoperative pain intensity. METHODS: We analyzed a total of 45 single-nucleotide polymorphisms of the adipokines in 57 patients with postlaparotomy pain...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29624642/cannabidiol-regulates-behavioural-alterations-and-gene-expression-changes-induced-by-spontaneous-cannabinoid-withdrawal
#11
Francisco Navarrete, Auxiliadora Aracil-Fernández, Jorge Manzanares
BACKGROUND AND PURPOSE: Cannabidiol (CBD) represents a promising therapeutic tool for treating cannabis use disorder (CUD). This study aimed to evaluate the effects of CBD on the behavioural and gene expression alterations induced by spontaneous cannabinoid withdrawal. EXPERIMENTAL APPROACH: Spontaneous cannabinoid withdrawal was evaluated 12 h after cessation of CP-55,940 treatment (0.5 mg·kg-1 /12 h; intraperitoneally (i.p.); 7 days) in C57BL/6J mice. The effects of CBD (5, 10 and 20 mg·kg-1 ; i...
April 6, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29623680/a-critical-review-of-methods-and-results-in-the-search-for-genetic-contributors-to-alcohol-sensitivity
#12
REVIEW
Marc A Schuckit
Attributes of alcohol sensitivity are present before alcohol use disorders (AUDs) develop, they predict those adverse alcohol outcomes, are familial in nature, and many are heritable. Whether measured by alcohol challenges or retrospective reports of numbers of drinks required for effects, alcohol sensitivity reflects multiple phenotypes, including low levels of alcohol response and alcohol-related stimulation. Identification of genes that contribute to alcohol sensitivity could help identify individuals carrying risks for AUDs through their alcohol responses for whom early intervention might mitigate their vulnerability...
April 5, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29616344/novel-pharmacological-nonopioid-therapies-in-chronic-pain
#13
REVIEW
Alan David Kaye, Elyse M Cornett, Brendon Hart, Shilpadevi Patil, Andrew Pham, Matthew Spalitta, Kenneth F Mancuso
PURPOSE OF REVIEW: Opioid use and abuse has led to a worldwide opioid epidemic. And while opioids are clinically useful when appropriately indicated, they are associated with a wide range of dangerous side effects and whether they are effective at treating or eliminating chronic pain is controversial. There has long been a need for the development of nonopioid alternative treatments for patients that live in pain, and until recently, only a few effective treatments were available. Today, there are a wide range of nonopioid treatments available including NSAIDs, acetaminophen, corticosteroids, nerve blocks, SSRIs, neurostimulators, and anticonvulsants...
April 3, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29615865/the-regulatory-mechanisms-and-therapeutic-potential-of-micrornas-from-chronic-pain-to-morphine-tolerance
#14
REVIEW
Zhao Dai, Haichen Chu, Jiahai Ma, Ying Yan, Xueying Zhang, Yongxin Liang
Chronic pain, including cancer-related pain, is a pain condition often caused by inflammation or dysfunctional nerves. Chronic pain treatment poses a significant health care challenge, where opioids especially morphine are widely used and patients often develop tolerance over time with aggravated pain. microRNA (miRNA) is known to play important roles in regulating gene expressions in the nervous system to affect neuronal network plasticity related to algogenesis and the developing of morphine tolerance. In this article, we reviewed studies conducted in rodent animal models investigating the mechanisms of miRNAs regulation in chronic pain with different phenotypes and morphine tolerance...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29615517/the-nociceptin-receptor-inhibits-axonal-regeneration-and-recovery-from-spinal-cord-injury
#15
Yuichi Sekine, Chad S Siegel, Tomoko Sekine-Konno, William B J Cafferty, Stephen M Strittmatter
Axonal growth after traumatic spinal cord injury is limited by endogenous inhibitors, selective blockade of which promotes partial neurological recovery. The partial repair phenotypes suggest that compensatory pathways limit improvement. Gene expression profiles of mice deficient in Ngr1 , which encodes a receptor for myelin-associated inhibitors of axonal regeneration such as Nogo, revealed that trauma increased the mRNA expression of ORL1 , which encodes the receptor for the opioid-related peptide nociceptin...
April 3, 2018: Science Signaling
https://www.readbyqxmd.com/read/29601950/association-between-mdr-1-cyp3a4-oprm-1-gene-polymorphisms-and-the-post-caesarean-fentanyl-analgesic-effect-on-chinese-women
#16
Jingliang Zhang, Li Zhang, Xia Zhao, Sheliang Shen, Xiaopan Luo, Yunlong Zhang
OBJECTIVE: Our study aimed to evaluate the association between the multidrug resistance 1 (MDR1 )/cytochrome P450 3A4 (CYP3A4)/μ-opioid receptor (OPRM1 ) gene polymorphisms and the post-caesarean analgesic effect of fentanyl on Chinese women. METHODS: We recruited 240 patients who received lower segment caesarean section surgeries. Sanger sequencing was used to analyze the MDR1 1236C > T/CYP3A4*1G/OPRM1 A118G polymorphisms. We evaluated post-operative fentanyl consumption and the effect of intravenous analgesia in patients with different genotypes...
March 27, 2018: Gene
https://www.readbyqxmd.com/read/29596446/gut-microbiota-varies-by-opioid-use-circulating-leptin-and-oxytocin-in-african-american-men-with-diabetes-and-high-burden-of-chronic-disease
#17
Elena Barengolts, Stefan J Green, Yuval Eisenberg, Arfana Akbar, Bharathi Reddivari, Brian T Layden, Lara Dugas, George Chlipala
OBJECTIVE: The gut microbiota is known to be related to type 2 diabetes (T2D), psychiatric conditions, and opioid use. In this study, we tested the hypothesis that variability in gut microbiota in T2D is associated with psycho-metabolic health. METHODS: A cross-sectional study was conducted among African American men (AAM) (n = 99) that were outpatients at a Chicago VA Medical Center. The main outcome measures included fecal microbiota ecology (by 16S rRNA gene sequencing), psychiatric disorders including opioid use, and circulating leptin and oxytocin as representative hormone biomarkers for obesity and psychological pro-social behavior...
2018: PloS One
https://www.readbyqxmd.com/read/29596097/repeated-morphine-prolongs-postoperative-pain-in-male-rats
#18
Peter M Grace, Erika L Galer, Keith A Strand, Kaci Corrigan, Debra Berkelhammer, Steven F Maier, Linda R Watkins
BACKGROUND: Opioids are effective postoperative analgesics. Disturbingly, we have previously reported that opioids such as morphine can worsen inflammatory pain and peripheral and central neuropathic pain. These deleterious effects are mediated by immune mediators that promote neuronal hyperexcitability in the spinal dorsal horn. Herein, we tested whether perioperative morphine could similarly prolong postoperative pain in male rats. METHODS: Rats were treated with morphine for 7 days, beginning immediately after laparotomy, while the morphine was tapered in a second group...
March 27, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29576267/interaction-between-the-opioid-receptor-oprm1-gene-and-mother-child-language-style-matching-prospectively-predicts-children-s-separation-anxiety-disorder-symptoms
#19
Sameen Boparai, Jessica L Borelli, Lindsey Partington, Patricia Smiley, Ella Jarvik, Hannah F Rasmussen, Lauren C Seaman, Erika L Nurmi
Recent research suggests that lower mother-child language style matching (LSM) is associated with greater physiological reactivity and insecure attachment in school-aged children, but to date no studies have explored this measure of parent-child behavioral matching for its association with children's anxiety symptoms, a well-known correlate of attachment insecurity and heightened physiological reactivity. There is also considerable evidence of genetic risk for anxiety, including possession of the OPRM1 minor allele, 118G...
March 22, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29575474/epigenetic-variation-in-oprm1-gene-in-opioid-exposed-mother-infant-dyads
#20
Elisha M Wachman, Marie J Hayes, Hira Shrestha, Fnu Nikita, Angela Nolin, Leonie Hoyo, Katrina Daigle, Hendrée E Jones, David A Nielsen
Neonatal abstinence syndrome (NAS) due to in-utero opioid exposure has significant variability of severity. Preliminary studies have suggested that epigenetic variation within the μ-opioid receptor (OPRM1) gene impacts NAS. We aimed to determine if DNA methylation in OPRM1 within opioid-exposed mother-infant dyads is associated with differences in NAS severity in an independent cohort. Full-term opioid-exposed newborns and their mothers (N=68 pairs) were studied. A DNA sample was obtained and then assessed for level of DNA methylation at 20 CpG sites within the OPRM1 promoter region by next-generation sequencing...
March 25, 2018: Genes, Brain, and Behavior
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