Jacob A Beierle, Emily J Yao, Stanley I Goldstein, William B Lynch, Julia L Scotellaro, Anyaa A Shah, Katherine D Sena, Alyssa L Wong, Colton L Linnertz, Olga Averin, David E Moody, Christopher A Reilly, Gary Peltz, Andrew Emili, Martin T Ferris, Camron D Bryant
Understanding the pharmacogenomics of opioid metabolism and behavior is vital to therapeutic success, as mutations can dramatically alter therapeutic efficacy and addiction liability. We found robust, sex-dependent BALB/c substrain differences in oxycodone behaviors and whole brain concentration of oxycodone metabolites. BALB/cJ females showed robust state-dependent oxycodone reward learning as measured via conditioned place preference when compared to the closely related BALB/cByJ substrain. Accordingly, BALB/cJ females also showed a robust increase in brain concentration of the inactive metabolite noroxycodone and the active metabolite oxymorphone compared to BALB/cByJ mice...
June 10, 2022: Journal of Pharmacology and Experimental Therapeutics