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Platelet rich fibrin

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https://www.readbyqxmd.com/read/29333517/safety-and-feasibility-of-platelet-rich-fibrin-matrix-injections-for-treatment-of-common-urologic-conditions
#1
Ethan L Matz, Amy M Pearlman, Ryan P Terlecki
Purpose: Autologous platelet rich plasma (PRP) is used increasingly in a variety of settings. PRP injections have been used for decades to improve angiogenesis and wound healing. They have also been offered commercially in urology with little to no data on safety or efficacy. PRP could theoretically improve multiple urologic conditions, such as erectile dysfunction (ED), Peyronie's disease (PD), and stress urinary incontinence (SUI). A concern with PRP, however, is early washout, a situation potentially avoided by conversion to platelet rich fibrin matrix (PRFM)...
January 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29326521/surgical-management-of-large-radicular-cyst-associated-with-mandibular-deciduous-molar-using-platelet-rich-fibrin-augmentation-a-rare-case-report
#2
Vijaya S Dhote, Nilima R Thosar, Sudhindra M Baliga, Priyanti Dharnadhikari, Poonam Bhatiya, Punit Fulzele
Radicular cysts arising from deciduous teeth are rare and usually cause a large bony defect. Autologous platelet-rich fibrin (PRF) is an easily available healing biomaterial in oral surgical defect with the new perspective of accelerated healing of a large bony defect. The present case is of unusually large radicular associated with neglected carious mandibular deciduous second molar in 10-year-old girl and its surgical management with PRF augmentation as a healing biomaterial in the bony defect. One-year follow-up showed uneventful healing and eruption of succedaneous tooth...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326502/comparative-evaluation-of-platelet-rich-fibrin-with-connective-tissue-grafts-in-the-treatment-of-miller-s-class-i-gingival-recessions
#3
Sonam Mufti, Sarvagna Mayank Dadawala, Phoram Patel, Monali Shah, Deepak Harish Dave
Background: One of the most common aesthetic problem encountered in the field of periodontology is gingival recession, which is, perceived by the patients as increase in length of teeth. The treatment of buccal gingival recession is a common requirement due to aesthetic concern or root sensitivity. This study was planned to evaluate the efficacy of PRF membrane compared to that of CTG in Miller's class I gingival recessions. Materials and Methods: 32 sites with Miller's Class I gingival recessions, out of which 16 sites received PRF (test) and 16 sites received CTG (control)...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29316445/does-intra-alveolar-application-of-chlorhexidine-gel-in-combination-with-platelet-rich-fibrin-have-an-advantage-over-application-of-platelet-rich-fibrin-in-decreasing-alveolar-osteitis-after-mandibular-third-molar-surgery-a-double-blinded-randomized-clinical
#4
Majid Eshghpour, Nasrin Danaeifar, Hamed Kermani, Amir Hossein Nejat
PURPOSE: To evaluate the effectiveness of chlorhexidine (CHX) gel and platelet-rich fibrin (PRF) compared with PRF alone in preventing the development of alveolar osteitis (AO). MATERIALS AND METHODS: In a double-blinded trial, patients undergoing surgical management of bilateral impacted mandibular third molars were randomly divided into 2 groups; 1 group received PRF in 1 extraction socket with the other socket as its control and the other group received 0.2% CHX gel plus PRF in 1 socket with the other socket serving as its control...
December 16, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29314633/leucocyte-and-platelet-rich-fibrin-a-carrier-of-autologous-multipotent-cells-for-regenerative-medicine
#5
Rosa Di Liddo, Thomas Bertalot, Alessio Borean, Ivan Pirola, Alberto Argentoni, Sandra Schrenk, Carola Cenzi, Stefano Capelli, Maria Teresa Conconi, Pier Paolo Parnigotto
The wound healing is a complex process wherein inflammation, proliferation and regeneration evolve according to a spatio-temporal pattern from the activation of coagulation cascade to the formation of a plug clot including fibrin matrix, blood-borne cells and cytokines/growth factors. Creating environments conducive to tissue repair, the haemoderivatives are commonly proposed for the treatment of hard-to-heal wounds. Here, we explored in vitro the intrinsic regenerative potentialities of a leucocyte- and platelet-rich fibrin product, known as CPL-MB, defining the stemness grade of cells sprouting from the haemoderivative...
January 5, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29314065/platelet-rich-fibrin-combined-with-a-porous-hydroxyapatite-graft-for-the-treatment-of-3-wall-intrabony-defects-in-chronic-periodontitis-a-randomized-controlled-clinical-trial
#6
A R Pradeep, Pavan Bajaj, Nishanth S Rao, Esha Agarwal, Savitha B Naik
BACKGROUND: Porous hydroxyapatite (HA) bone grafting material has been used to fill periodontal intrabony defects (IBDs), resulting in clinically acceptable responses. Platelet-rich fibrin (PRF) is a leukocyte and platelet preparation that concentrates various polypeptide growth factors and, therefore, has the potential for use as regenerative treatment for periodontal defects. The present study aims to explore the clinical and radiographic effectiveness of autologous PRF versus PRF + HA in treatment of IBDs in patients with chronic periodontitis...
December 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/29304325/effects-of-leukocyte-and-platelet-rich-fibrin-alone-and-combined-with-hyaluronic-acid-on-pain-edema-and-trismus-after-surgical-extraction-of-impacted-mandibular-third-molars
#7
İbrahim Murat Afat, Emine Tuna Akdoğan, Onur Gönül
PURPOSE: In this prospective, randomized, double-blind controlled study, we evaluated the effects of leukocyte- and platelet-rich fibrin (L-PRF) alone and combined with a hyaluronic acid (HA) sponge on pain, edema, and trismus after mandibular third molar surgery. PATIENTS AND METHODS: In total, 60 patients were included in this study. The patients were randomly divided into 3 groups: L-PRF group (L-PRF was applied to the socket), L-PRF-plus-HA group (L-PRF combined with HA was applied to the socket), and control group (nothing was applied)...
December 13, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29288732/blood-derivatives-awaken-in-regenerative-medicine-strategies-to-modulate-wound-healing
#8
Bárbara B Mendes, Manuel Gómez-Florit, Pedro S Babo, Rui L Reis, Rui M A Domingues, Manuela E Gomes
Blood components play key roles in the modulation of the wound healing process and, together with the provisional fibrin matrix ability to selectively bind bioactive molecules and control its spatial-temporal presentation, define the complex microenvironment that characterize this biological process. As a biomimetic approach, the use of blood derivatives in regenerative strategies has awaken as a source of multiple therapeutic biomolecules. Nevertheless, and despite their clinical relevance, blood derivatives have been showing inconsistent therapeutic results due to several factors, including proper control over their delivery mechanisms...
December 27, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29287951/the-effect-of-platelet-rich-fibrin-matrix-at-the-time-of-gluteus-medius-repair-a-retrospective-comparative-study
#9
Bryan M Saltzman, Gift Ukwuani, Eric C Makhni, Jeffrey P Stephens, Shane J Nho
PURPOSE: To evaluate the effect of platelet-rich fibrin matrix (PRFM) on outcomes after surgical repair of gluteus medius tendons. METHODS: This is a retrospective review of prospectively collected data comparing patients who underwent gluteus medius repair with PRFM and patients without PRFM. Preoperative characteristics, intraoperative characteristics, and postoperative outcomes at a minimum of 1 year were recorded. Statistical analysis was performed using a multivariate analysis of variance to test for differences in continuous demographic variables and postoperative-only scores between patient groups, χ2 tests were performed for categorical variables, and a repeated-measures analysis of variance was performed to test for the effects of PRFM...
December 26, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29287741/uncertainty-about-the-lack-of-benefits-of-platelet-rich-fibrin-as-an-adjunct-to-coronally-advanced-flap-for-treating-gingival-recessions
#10
Romina Brignardello-Petersen
No abstract text is available yet for this article.
December 23, 2017: Journal of the American Dental Association
https://www.readbyqxmd.com/read/29284978/successful-surgical-management-of-palatogingival-groove-using-platelet-rich-fibrin-and-guided-tissue-regeneration-a-novel-approach
#11
J V Karunakaran, Susan Mathew Fenn, N Jayaprakash, N Ragavendran
Palatogingival groove also known as radicularlingual groove is a developmental anomaly involving the lingual surface of the maxillary incisors. They are inconspicuous, funnel-shaped, extend for varying distances on root surface and occur due to infolding of the hertwigs epithelial root sheath. This encourages adherence of microorganisms and plaque to levels significant for pathological changes resulting in endodontic and periodontal lesions. The variations in anatomy of the tooth as a cause of pulp necrosis in teeth of anterior maxillary segment should be considered by the clinician when other etiological factors are ruled out...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29284945/comparison-of-marginal-periosteal-pedicle-graft-and-bioactive-glass-with-platelet-rich-fibrin-and-bioactive-glass-in-the-treatment-of-intrabony-defects-a-clinicoradiographic-study
#12
M S Yasaswini, K V Prabhakara Rao, P Tanuja, Narendra Reddy Motakatla
Introduction and Objectives: The objective of the study was to compare clinically and radiographically the regenerative potential of marginal periosteal pedicle graft (MPPG) or platelet-rich fibrin (PRF) with a bioactive glass in the treatment of two- and three-wall intrabony defects. Methods: A total of 28 sites (bilateral or contralateral infrabony defects) from 14 patient were treated with MPPG (Experimental site A) and the other site was treated with PRF (Experimental site B)...
November 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29279679/effectiveness-of-platelet-rich-fibrin-in-the-management-of-pain-and-delayed-wound-healing-associated-with-established-alveolar-osteitis-dry-socket
#13
Ashish Sharma, Nimish Aggarwal, Sanjay Rastogi, Rupshikha Choudhury, Siddhi Tripathi
Objective: To assess the efficacy of platelet-rich fibrin (PRF) on the pain and healing of the extraction socket related with established alveolar osteitis (dry socket, AO) after the removal of maxillary and mandibular molars. Materials and Methods: One hundred consecutive adult patients with age group ranging from 18 to 40 years along with established dry socket after maxillary and mandibular molar extractions who have not received any treatment for the same were included in this single-arm clinical trial...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29260758/-regeneration-of-dental-pulp-tissue-using-pulpal-autologous-mesenchymal-stem-cells-and-platelet-rich-plasma
#14
A A Kulakov, D V Goldshtein, E K Krechina, T B Bukharova, A V Volkov, A K Gadzhiev
Regeneration of pulp and dentin could be important in operative dentistry as a method to save teeth. Currently cell population from dental pulp of deciduous and permanent teeth of humans and laboratory animals are isolated and characterized. The paper presents a study on pulp regeneration using autologous mesenchymal stromal cells from pulp of molars in combination with fibrin clot, transplanted in pulp chamber of miniature pigs after pulp removal. The results proved that transplantation of autologous multipotent stromal cells of dental pulp in combination with autologous platelet-rich plasma in pulp chamber of miniature pigs after pulp removal leads to pulp restoration and reparative dentinogenesis with dentinal bridge formation on the 30th day...
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/29240523/injectable-platelet-rich-fibrin-using-the-low-speed-centrifugation-concept-improves-cartilage-regeneration-when-compared-to-platelet-rich-plasma
#15
Mustafa Abd El Raouf, Xuzhu Wang, Si Miusi, Jihua Chai, Abdel Basit Mohamed AbdEl-Aal, Mekkawy M Nefissa Helmy, Shahram Ghanaati, Joseph Choukroun, Elisa Choukroun, Yufeng Zhang, Richard J Miron
The aim of the present study was to evaluate the effect of injectable platelet-rich fibrin (i-PRF) on cultivated chondrocytes and osteochondral regeneration in critical-sized osteochondral defect of the rabbit's knee in comparison to autologous platelet-rich plasma (PRP). Chondrocytes were first investigated for their ability to proliferate and differentiate in response to PRP and i-PRF. Thereafter, full-thickness critical-sized osteochondral defects 5 mm in diameter and 5 mm in depth were created in the knee joint of 12 adult female New Zealand White rabbits...
December 14, 2017: Platelets
https://www.readbyqxmd.com/read/29235312/basics-of-platelet-rich-fibrin-therapy
#16
Richard J Miron, Mark Bishara, Joseph Choukroun
No abstract text is available yet for this article.
April 2017: Dentistry Today
https://www.readbyqxmd.com/read/29215443/scaffold-free-bone-regeneration-using-platelet-rich-fibrin-in-calvarial-defect-model
#17
Yeo Reum Jeon, Mi Jung Kim, Yong Oock Kim, Tai Suk Roh, Won Jai Lee, Eun Hye Kang, In Sik Yun
Bone regeneration is a complex process influenced by various physiological factors. Platelet-rich plasma (PRP) contains many growth factors and has shown osteogenic effects. The PRP is usually activated before use. However, the authors showed that nonactivated PRP (nPRP) and activated PRP have comparable osteogenic effects in the previous study. Generally, a scaffold has been needed for the application of PRP in the cranial defect model. In this study, the authors aimed to compare the performance of scaffold free platelet-rich fibrin (PRF) to nPRP as an adjuvant for bone regeneration...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29209937/sugar-based-collagen-membrane-cross-linking-increases-barrier-capacity-of-membranes
#18
Po-Ju Chia-Lai, Anna Orlowska, Sarah Al-Maawi, Andre Dias, Yunxin Zhang, Xuejiu Wang, Niklas Zender, Robert Sader, C James Kirkpatrick, Shahram Ghanaati
OBJECTIVES: This study examines the permeability and barrier capacity of a sugar cross-linked resorbable collagen membrane ex vivo and in vivo. MATERIALS AND METHODS: In an ex vivo study, injectable platelet-rich fibrin (i-PRF), a peripheral blood-derived human leukocyte-and-platelet-rich plasma was used to analyze membrane permeability. in vivo subcutaneous implantation in Wistar rats (n = 4 per time point and group) was used to investigate the barrier capacity of the membrane...
December 6, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/29207216/the-roles-of-cellular-and-molecular-components-of-a-hematoma-at-early-stage-of-bone-healing
#19
REVIEW
Hoi Ting Shiu, Ping Chung Leung, Chun Hay Ko
Bone healing is a complex repair process which commences with formation of a blood clot at the injured bone, termed hematoma. It has evidenced that a lack of a stable hematoma causes delayed bone healing or non-union. The hematoma at the injured bone constitutes the early healing microenvironment. It appears to dictate healing pathways which ends in a regenerative bone. However, the hematoma is often clinically removed from the damaged site. Conversely, blood-derived products have been used in bone tissue engineering for treating critical sized defects (CSDs), including fibrin gels and platelet rich plasma...
December 5, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29197444/a-leukocyte-and-platelet-rich-fibrin-showed-a-regenerative-potential-in-intrabony-defects-and-furcation-defects-but-not-in-periodontal-plastic-surgery
#20
Zuhair S Natto, Martyn S Green
ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis. Castro AB, Meschi N, Temmerman A, Pinto N, Lambrechts P, Teughels W, Quirynen M. J Clin Periodontol 2017; 44(1):67-82. SOURCE OF FUNDING: Self-funded by the authors and their institution TYPE OF STUDY/DESIGN: Systematic review with meta-analysis of data...
December 2017: Journal of Evidence-based Dental Practice
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