Read by QxMD icon Read

Platelet rich fibrin

Necdet Özçay, Handan Özdemir, Hasan Besim
OBJECTIVES: The aim of the present study is to investigate the role of platelet rich fibrin(PRF) on the intestinal anastomotic wound healing in a mesenteric ischemia/reperfusion (I/R) rat model. METHODS: Forty male Sprague Dawley rats were allocated into four groups: Group I (n=10) Anastomosis to normal bowel; Group II (n=10) Anastomosis after I/R injury; Group III (n=10) Anastomosis and PRF; Group IV Anastomosis after I/R and PRF. Animals were followed up for 7 days, then sacrificed...
March 22, 2018: Biomedical Materials
Caroline J Reddel, Gabrielle J Pennings, Jennifer L Curnow, Vivien M Chen, Leonard Kritharides
Platelets play an important role in diseases such as cardiovascular disease and cancer, especially through their release of extracellular vesicles (EVs) and role in thrombosis. The effects of the anti-inflammatory drug colchicine on platelets are not well understood. We investigated the effect of colchicine on the release of pro-coagulant EVs from platelets under low-level activation. Citrated platelet-rich plasma (PRP) from healthy donors was incubated with 2 mM colchicine or vehicle at 37°C for 30 minutes with gentle rotation...
March 19, 2018: Thrombosis and Haemostasis
Taner Arabaci, Mevlut Albayrak
BACKGROUND: The aim of this study to evaluate the contributions of titanium-prepared platelet-rich fibrin (T-PRF) combined with open flap debridement (OFD) on biological markers in gingival crevicular fluid (GCF)and periodontal outcomes. METHODS: Twenty-nine participants with chronic periodontitis were treated either with autologous T-PRF+OFD or OFD alone. GCF growth factor levels and relative receptor activator nuclear factor kappa-B/osteoprotegerin (RANKL/OPG) ratio at baseline and 2, 4, and 6 weeks postoperatively were analyzed, and clinical parameters such as probing depth (PD), relative attachment level (RAL) and gingival margin level (GML) at baseline and 9 months after surgery were compared...
March 2018: Journal of Periodontology
Roshan Noor Mohamed, Sakeenabi Basha, Yousef Al-Thomali
The main purpose of the present systematic review was to evaluate the efficacy of platelet concentrates in pulpotomy of human teeth. Our systematic search included Medline, Embase, CINAHL, PsycINFO, Scopus, key journals, and review articles; the date of the last search was July 30, 2017. We graded the methodological quality of the studies by Cochrane Risk of Bias tool. Four randomized controlled trails were included in the present systematic review. The number of study participants ranged from 28 to 50, with a mean of 45...
March 14, 2018: Platelets
A A Alhasyimi, P P Pudyani, W Asmara, I D Ana
OBJECTIVE: To evaluate the effect of carbonated hydroxyapatite-incorporated advanced platelet-rich fibrin on relapse and bone remodelling in rabbits. MATERIALS AND METHODS: Forty-five rabbits were divided into 3 groups (n = 15): a control group, carbonated hydroxyapatite (CHA) and carbonated hydroxyapatite-incorporated advanced platelet-rich fibrin (CHA-aPRF) group. The lower incisors were subjected to an orthodontic force of 50 cN. During the retention period, CHA and CHA-aPRF hydrogel were gently injected in the mesial gingival sulcus every 7 days...
March 14, 2018: Orthodontics & Craniofacial Research
Maha A Bahammam
OBJECTIVE: This prospective randomized clinical trial was conducted to determine whether the application of a platelet-rich fibrin (PRF) palatal bandage after harvesting free gingival grafts (FGG) would improve healing of donor sites and decrease pain scores and patient discomfort. MATERIALS AND METHODS: Twenty-four patients received FGG to augment keratinized tissue dimensions. The application of a PRF bandage was decided randomly (n = 12 in each group). Patients reported their pain levels for the first 7 days of healing using the visual analog scale (VAS), 101-point numerical rating scale (NRS-101), and 4-point verbal rating scale (VRS-4)...
March 9, 2018: Clinical Oral Investigations
Nastaran Meschi, Steffen Fieuws, Anke Vanhoenacker, Olaf Strijbos, Dominique Van der Veken, Constantinus Politis, Paul Lambrechts
OBJECTIVES: The aim of this study was to investigate the impact of the adjunct of leukocyte- and platelet-rich fibrin (LPRF) to root-end surgery (RES) on the patients' quality of life during the first week post RES. MATERIALS AND METHODS: Patients in need of RES were recruited for an open randomized controlled clinical trial (RCT) with a 2 × 2 factorial design. They were randomly allocated to the test (+LPRF) and control (-LPRF) group. Each group was subsequently divided into two strata: with or without an occlusive membrane (Bio-Gide®, Geistlich Biomaterials, Switzerland; BG)...
March 9, 2018: Clinical Oral Investigations
Alica Kubesch, Mike Barbeck, Sarah Al-Maawi, Anna Orlowska, Patrick F Booms, Robert A Sader, Richard J Miron, Charles J Kirkpatrick, Joseph Choukroun, Shahram Ghanaati
Platelet-rich fibrin (PRF) is generated from the patients' own venous blood by a single centrifugation step without the additional use of anticoagulants. Based on the previously described LSCC (low-speed centrifugation concept), our group showed that modification of the centrifugation setting, that is, reducing the relative centrifugal force (RCF) and mildly increasing the centrifugation time, resulted in modified solid and liquid PRF-matrices with increased number of platelets, leukocytes, and growth factors' concentrations...
March 6, 2018: Platelets
Ajay C Lall, Benjamin G Domb
The use of biologic augments such as platelet-rich plasma and platelet-rich fibrin for tendon pathology has skyrocketed within the past 5-7 years amongst orthopaedic patients. Many retrospective series exist with small sample sizes and variable clinical applications. Patient psyche, price of product, and outcomes may be more intimately related than once thought. In this commentary, we briefly review the placebo and psychometric effect of medicine.
March 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
Wael M Talaat, Mohamed M Ghoneim, Omar Salah, Osama A Adly
Stem cell therapy is a revolutionary new way to stimulate mesenchymal tissue regeneration. The platelets concentrate products started with platelet-rich plasma (PRP), followed by platelet-rich fibrin (PRF), whereas concentrated growth factors (CGF) are the latest generation of the platelets concentrate products which were found in 2011. The aim of the present study was to evaluate the potential of combining autologous bone marrow concentrates and CGF for treatment of bone defects resulting from enucleation of mandibular pathologic lesions...
February 23, 2018: Journal of Craniofacial Surgery
Eoghan T Hurley, Daren Lim Fat, Cathal J Moran, Hannan Mullett
BACKGROUND: Basic science studies suggest that platelet-rich therapies have a positive effect on tendon repair. However, the clinical evidence is conflicted on whether this translates to increased tendon healing and improved functional outcomes. PURPOSE: To perform a systematic review of randomized controlled trials (RCTs) in the literature to ascertain whether platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) improved patient outcomes in arthroscopic rotator cuff repair...
February 1, 2018: American Journal of Sports Medicine
H Unsal, G N H Erbasar
Aims: To evaluate whether the alveolar osteitis (AO) incidence after extracting partially erupted third molars differs when platelet-rich fibrin (PRF) is administered in the alveolar socket and to assess the influence of PRF on postoperative pain levels and periodontal probing depth. Settings and Design: In this split-mouth randomized study, 50 patients (17 men/ 33 women; mean age, 23.96 years) with bilateral symmetric partially erupted mandibular third molars were enrolled...
February 2018: Nigerian Journal of Clinical Practice
Gustavo Da Dos Santos Pinto, Suzane Cristina Pigossi, Tércio Pessoa, Lélis Gustavo Nícoli, Raphael Ferreira de Souza Bezerra Araújo, Cláudio Marcantonio, Elcio Marcantonio
PURPOSE: The aim of this case report was to demonstrate the repair of a large sinus membrane perforation related to a sinus floor augmentation procedure, using leukocyte platelet-rich fibrin (L-PRF), for subsequent rehabilitation of a partially edentulous patient. MATERIALS AND METHODS: The patient presented the absence of teeth numbers 18, 17, and 16, associated with insufficient bone height because of the maxillary sinus pneumatization. A maxillary inlay bone graft was proposed, however, during the sinus floor augmentation procedure, a large portion of the sinus membrane was ruptured...
February 16, 2018: Implant Dentistry
Najwa Jamil Abdulrazzak Al-Chalabi, Ahmed Fadhil Al-Quisi, Thair Abdul Lateef
AIM: This study was designed to evaluate the role of single session autologous facial fat grafting in correcting facial asymmetries after mixing it with platelet-rich fibrin (PRF) and injecting them into rich vascular facial muscular plane. MATERIALS AND METHODS: Fifteen patients (12 females and 3 males) with age ranging from 18 years to 40 years were included in this study and followed up during 6 months, all the patients were treated in the Al-Shaheed Ghazi Al-Hariri for specialized surgeries hospital (Medical City, Baghdad, Iraq)...
February 14, 2018: Journal of Craniofacial Surgery
Lisa Baumann Kreuziger, Mark S Slaughter, Kartik Sundareswaran, Alan E Mast
Left ventricular assist device (LVAD) thrombosis is a devastating complication that occurs in about 10% of patients despite anticoagulation and antiplatelet treatment. How the thrombus initiates and propagates is unknown. We pathologically and immunohistochemically examined 28 thrombi removed from 17 HeartMate II LVADs. Two groups of thrombi were found: those formed in the inlet/outlet and those on the rotor. The four thrombi found at the inlet (three inlet conduit and one inlet tube) and outlet (three at outlet elbow and one outlet graft) appeared similar and were composed of a loose meshwork of fibrin(ogen), von Willebrand factor, leukocytes, and aggregated platelets...
February 15, 2018: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
Elton Carlos Pichotano, Rafael Scaf de Molon, Luiz Guilherme Freitas de Paula, Ricardo Violante de Souza, Elcio Marcantonio, Daniela Leal Zandim-Barcelos
This case report aimed to describe the effects of leukocyte and platelet-rich fibrin (L-PRF) associated with deproteinized bovine bone mineral (DBBM) and absorbable collagen membrane (CM) on bone regeneration in maxillary sinus augmentation. A 59-year-old male patient was referred to the Department of Periodontology for implant rehabilitation of his edentulous upper jaw. The treatment plan involved maxillary sinus augmentation followed by implants installation. A split-mouth design was employed, in which the right maxillary sinus was filled using L-PRF, DBBM, and CM; the left side was filled with DBBM and CM...
February 19, 2018: Journal of Oral Implantology
Yingdi Zhang, Zheng Ruan, Minhua Shen, Luanjun Tan, Weiqin Huang, Lei Wang, Yuanliang Huang
The aim of the present study was to evaluate the clinical efficacy of platelet-rich fibrin (PRF) in preserving the alveolar ridge following human tooth extraction. A total of 28 patients were divided into two groups: The experimental and control groups (n=14 each). Following tooth extraction, the experimental group was implanted with PRF membrane, whereas the control group was not. The gingival healing effect was assessed at 7 days, 1 and 3 months later. Cone-beam computed tomography was performed immediately and at 3 months following tooth extraction...
March 2018: Experimental and Therapeutic Medicine
Anuradha Bhatsange, Alkesh Shende, Sabina Deshmukh, Sharanabasappa Japatti
Fenestration and dehiscence are said to be anatomical variations of cortical bone and not true pathological entities. They represent window-like defects covered by periosteum and overlying gingiva with or without the intact marginal bone. The etiology of such defects is still unclear, though many hypotheses such as occlusal traumatism, trauma, and variation in root bone angulation have been put forward. Diagnosis of such defects is challenging clinically, and they cannot be appreciated in conventional radiographs...
July 2017: Journal of Indian Society of Periodontology
Parul Sharma, Harpreet Singh Grover, Sujata Surendra Masamatti, Neha Saksena
Background: Management of furcation defects is challenging, and constantly newer therapeutic strategies are evolving. Platelet-rich fibrin (PRF) is successfully used alone and in combination with various agents in the furcation defects. Lately, metformin (MF), a second generation biguanide has gained popularity owing to its osteogenic potential. Aims and Objectives: The aim of the present study was to evaluate the clinical and radiographic effectiveness of open flap debridement (OFD) and PRF when compared to OFD + PRF + 1% MF gel in the management of mandibular Grade II furcation defects...
July 2017: Journal of Indian Society of Periodontology
Yutaka Kitamura, Taisuke Watanabe, Masayuki Nakamura, Kazushige Isobe, Hideo Kawabata, Kohya Uematsu, Kazuhiro Okuda, Koh Nakata, Takaaki Tanaka, Tomoyuki Kawase
Platelet-rich fibrin (PRF) clots have been used in regenerative dentistry most often, with the assumption that growth factor levels are concentrated in proportion to the platelet concentration. Platelet counts in PRF are generally determined indirectly by platelet counting in other liquid fractions. This study shows a method for direct estimation of platelet counts in PRF. To validate this method by determination of the recovery rate, whole-blood samples were obtained with an anticoagulant from healthy donors, and platelet-rich plasma (PRP) fractions were clotted with CaCl2 by centrifugation and digested with tissue-plasminogen activator...
2018: Frontiers in Bioengineering and Biotechnology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"