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Platelet rich fibrin

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https://www.readbyqxmd.com/read/29782513/high-red-blood-cell-composition-in-clots-is-associated-with-successful-recanalization-during-intra-arterial-thrombectomy
#1
Jong Wook Shin, Hye Seon Jeong, Hyon-Jo Kwon, Kyu Sang Song, Jei Kim
We evaluated the composition of individual clots retrieved during intra-arterial thrombectomy in relation to recanalization success, stroke subtype, and the presence of clot signs on initial brain images. We analyzed clot and interventional data from 145 retrieval trials performed for 37 patients (69.5±14.0 years, 20 men, large artery atherosclerosis, n = 7; cardioembolism, n = 22; undetermined etiology, n = 8) who had undergone intra-arterial thrombectomy. Rates of clot retrieval and successful recanalization (Arterial Occlusive Lesion score of 2-3) for separate retrieval trials were evaluated...
2018: PloS One
https://www.readbyqxmd.com/read/29781765/individualized-titanium-mesh-combined-with-platelet-rich-fibrin-and-deproteinized-bovine-bone-a-new-approach-for-challenging-augmentation
#2
Jonas Lorenz, Sarah Al-Maawi, Robert Sader, Shahram Ghanaati
Autologous bone transfer is regarded as the gold standard for ridge augmentation before dental implantation, especially in severe bony defects caused by tumor resection or atrophy. In addition to the advantages of autologous bone, transplantation has several disadvantages, such as secondary operation, increased morbidity and pain. The present study reports, for the first time, a combination of a xenogeneic bone substitute (BO) with platelet-rich fibrin (PRF), which is a fully autologous blood concentrate derived from the patient's own peripheral blood by centrifugation...
May 21, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29777616/regenerative-endodontics-a-review
#3
REVIEW
S G Kim, M Malek, A Sigurdsson, L M Lin, B Kahler
The European Society of Endodontology and the American Association for Endodontists have released position statements and clinical considerations for regenerative endodontics. There is increasing literature on this field since the initial reports of Iwaya et al. (2001) and Banchs & Trope (2004). Endogenous stem cells from an induced periapical bleeding and scaffolds using blood clot, platelet rich plasma or platelet rich fibrin have been utilized in regenerative endodontics. This approach has been described as a 'paradigm shift" and considered the first treatment option for immature teeth with pulp necrosis...
May 19, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29772345/autologous-liquid-platelet-rich-fibrin-a-novel-drug-delivery-system
#4
REVIEW
Richard J Miron, Yufeng Zhang
There is currently widespread interest within the biomaterial field to locally deliver biomolecules for bone and cartilage regeneration. Substantial work to date has focused on the potential role of these biomolecules during the healing process, and the carrier system utilized is a key factor in their effectiveness. Platelet rich fibrin (PRF) is a naturally derived fibrin scaffold that is easily obtained from peripheral blood following centrifugation. Slower centrifugation speeds have led to the commercialization of a liquid formulation (liquid-PRF) resulting in an upper plasma layer composed of liquid fibrinogen/thrombin prior to clot formation that remains in its liquid phase for approximately 15 minutes until injected into bodily tissues...
May 14, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29769770/clinical-and-histological-evaluation-on-application-of-platelet-concentrates-on-depigmented-gingival-epithelium
#5
Koel Debnath, Anirban Chatterjee
Background: The platelet concentrate is a windfall in the field of regenerative therapy in periodontology. It accelerates wound healing by excellent neovascularization and promoting fast cicatricle tissue remodeling. Aim: This study aims to evaluate clinically and histologically accelerated effect of platelet-rich fibrin (PRF) membrane and PRF matrix (PRFM) following depigmentation procedure. Materials and Methods: Eleven individuals were divided into three groups after depigmentation procedure...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29769769/evaluation-of-periosteum-eversion-and-coronally-advanced-flap-techniques-in-the-treatment-of-isolated-miller-s-class-i-ii-gingival-recession-a-comparative-clinical-study
#6
Koel Debnath, Anirban Chatterjee
Aim: The present investigation aimed to evaluate root coverage (RC) with periosteum eversion technique (PET) using periosteum as a graft and coronally advanced flap (CAF) with platelet-rich fibrin (PRF) membrane as a graft in the treatment of isolated Miller's class I and II gingival recession defects. Materials and Methods: Thirty sites in 15 participants with Miller's Class I or II gingival recession were randomly treated either with PET using periosteum as graft and CAF + PRF as graft...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29768536/comparison-of-platelet-rich-plasma-versus-fibrin-glue-on-colonic-anastomoses-in-rats
#7
Yusuf Kenan Daglioglu, Ozgul Duzgun, Inanc Samil Sarici, Kemal Turker Ulutas
PURPOSE: To compare platelet rich plasma (PRP) and fibrin glue about the effect of anastomotic healing. METHODS: Thirty six Wistar-Albino male rats diveded into 3 groups according to control(Group1), PRP (Group 2) and fibrin glue(Tisseel VH) (Group 3). The colon was transected with scissor and subsequently an end to end anastomosis was performed using continuous one layer 6/0 vicryl sutures. Postoperative 7th day effect of anastomotic healing measuring with tissue hydroxyproline(TH) level and anastomotic bursting pressure(ABP); moreover comparison of cytokine (IL-6 and IL-10) and procalcitonin levels on 1st,3rd and 7th days...
April 2018: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/29768524/evaluation-of-the-effect-of-dose-dependent-platelet-rich-fibrin-membrane-on-treatment-of-gingival-recession-a-randomized-controlled-clinical-trial
#8
Rana Culhaoglu, Levent Taner, Berceste Guler
Miller's class I gingival recessions (GR) have been treated using coronally advanced flap (CAF) with platelet-rich fibrin membrane (PRF membrane) or connective tissue graft (CTG). The aim of this study was to evaluate the effect of different multiple layers of PRF membranes for the treatment of GR compared with the CTG procedure. Sixty-three Miller class I GR were treated in this study. Twenty-one GR selected randomly were treated with two layers of PRF membranes+CAF in 2PRF+CAF (test group-1), four layers of PRF membranes+CAF in 4PRF+CAF (test group-2), and CTG+CAF in the control group...
May 14, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29768259/precise-intradermal-injection-of-nanofat-derived-stromal-cells-combined-with-platelet-rich-fibrin-improves-the-efficacy-of-facial-skin-rejuvenation
#9
Zhi-Jie Liang, Xiang Lu, De-Quan Li, Yi-Dan Liang, Dan-Dan Zhu, Fang-Xiao Wu, Xiao-Lin Yi, Ning He, Yan-Qing Huang, Chao Tang, Hong-Mian Li
BACKGROUND/AIMS: The rejuvenation properties of nanofat grafting have been described in recent years. However, it is not clear whether the clinical efficacy of the procedure is attributable to stem cells or linked to other components of adipose tissue. In this study we isolated nanofat-derived stem cells (NFSCs) to observe their biological characteristics and evaluate the efficacy of precise intradermal injection of nanofat combined with platelet-rich fibrin (PRF) in patients undergoing facial rejuvenation treatment...
May 11, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29763577/comparison-of-the-regenerative-effects-of-platelet-rich-fibrin-and-plasma-rich-in-growth-factors-on-injured-peripheral-nerve-an-experimental-study
#10
Damla Torul, Mehmet Cihan Bereket, Mehmet Emin Onger, Gamze Altun
PURPOSE: The aim of this study was to investigate the effects of platelet-rich fibrin (PRF) and plasma rich in growth factors (PRGF) on peripheral nerve injury in the early period of healing. MATERIAL AND METHODS: Thirty Wistar albino rats were used in this study. Rats were divided into control (C), damaged (D), PRF, and PRGF groups. The left sciatic nerves of each group were identified as group C. Crush-type injury was performed on the right sciatic nerves of the D, PRF, and PRGF groups...
April 20, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29761887/telomere-length-and-genetic-variations-affecting-telomere-length-as-biomarkers-for-facial-regeneration-with-platelet-rich-fibrin-based-on-the-low-speed-centrifugation-concept
#11
Cleopatra Nacopoulos, Kalliopi Gkouskou, Dimitrios Karypidis, Ioannis Vlastos, Anna-Maria Vesala, Joseph Choukroun, Richard J Miron, Emmanuel Prokopakis
BACKGROUND: Platelet-Rich Fibrin (PRF), a fibrin matrix produced by single blood centrifugation that contains leukocytes, platelets, and growth factors, is increasingly being utilized for facial regeneration purposes. However, our understanding of the involved pathophysiological mechanisms affecting regeneration is limited and current protocols require better optimization. Biomarkers that are related to skin aging such as telomere length (TL) have been proposed as a mean to analyze patients' stratification...
May 15, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29744191/synergistic-effects-of-the-combined-use-of-human-cultured-periosteal-sheets-and-platelet-rich-fibrin-on-bone-regeneration-an-animal-study
#12
Makoto Horimizu, Takehiko Kubota, Tomoyuki Kawase, Masaki Nagata, Mito Kobayashi, Kazuhiro Okuda, Koh Nakata, Hiromasa Yoshie
A human-cultured alveolar bone-derived periosteal (hCP) sheet is an osteogenic grafting material used clinically in periodontal regenerative therapy, while platelet-rich fibrin (PRF), a platelet concentrate with fibrin clot, is considered to augment the wound healing process. Therefore, whether the combined use of hCP-PRF complex could facilitate bone regeneration synergistically was evaluated in animal models. Human periosteal segments (1 × 1 mm) were cultured initially on plastic dishes and formed an hCP sheet...
August 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29722762/prp-as-an-adjunct-to-rotator-cuff-tendon-repair
#13
F Alan Barber
Arthroscopic rotator cuff repair is a commonly performed repair. Technical developments provide surgeons the tools to create biomechanically robust repairs. How can the biological response mirror the strong and stable surgery? Platelet-rich plasma (PRP) is a supraphysiological platelet concentration which may positively augment rotator cuff healing. Not all PRPs are the same. High leukocyte levels and thrombin activation may be detrimental to tendon healing. Thrombin activation triggers an immediate release of growth factors and may actually inhibit some parts of the healing response...
June 2018: Sports Medicine and Arthroscopy Review
https://www.readbyqxmd.com/read/29713784/limited-evidence-for-adipose-derived-stem-cell-therapy-on-the-treatment-of-osteoarthritis
#14
REVIEW
Eoghan T Hurley, Youichi Yasui, Arianna L Gianakos, Dexter Seow, Yoshiharu Shimozono, Gino M M J Kerkhoffs, John G Kennedy
PURPOSE: The purpose of this systematic review is to evaluate the effects of adipose derived mesenchymal stem cells (ADSCs) in the treatment of osteoarthritis (OA) in the clinical setting. METHODS: A literature search was performed in the MEDLINE, EMBASE, and The Cochrane Library Database up to January 2017 for inclusion and exclusion criteria. Criteria for inclusion were clinical studies demonstrating the effects of ADSCs on OA, and written in English. The following variables were analyzed: donor site, volume of adipose tissue, preparation of ADSCs, clinical outcomes, and complication rate...
April 30, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29704865/platelet-rich-fibrin-and-its-contradictory-effect-on-peripheral-nerve-repair-after-malignant-tumor-resection-nerve-regeneration-versus-cancer-proliferation
#15
Eleftherios Spartalis, Demetrios Moris, Panagiotis Zis, Themistoklis I Papasilekas, Dimitrios Schizas, Nikolaos Nikiteas
No abstract text is available yet for this article.
April 28, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29703620/a-comparative-evaluation-of-concentrated-growth-factor-and-platelet-rich-fibrin-on-the-proliferation-migration-and-differentiation-of-human-stem-cells-of-the-apical-papilla
#16
Shebin Hong, Weiting Chen, Beizhan Jiang
INTRODUCTION: Concentrated growth factor (CGF) is considered to be a natural biomaterial that is better than platelet-rich fibrin (PRF) in bone regeneration, but there is little information acquired in regenerative endodontics. Therefore, the purpose of this study was to evaluate their effects on the proliferation, migration, and differentiation of human stem cells of the apical papilla (SCAPs). METHODS: CGF- and PRF-conditioned medium were prepared using the freeze-dried method...
April 24, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29703061/endoscopically-controlled-flapless-transcrestal-sinus-floor-elevation-with-platelet-rich-fibrin-followed-by-simultaneous-dental-implant-placement-a-case-report-and-literature-review
#17
Zhenzhen Liu, Chunyan Li, Jing Zhou, Xiaolin Sun, Xue Li, Manlin Qi, Yanmin Zhou
RATIONALE: In this case study, a modified transcrestal approach was applied to the patient of extremely atrophic posterior maxilla. We analysis the Implant Stability Quotient values (ISQ) to monitor implant stability, and the cone-beam computer tomography (CBCT) to evaluate the bone regeneration. PATIENT CONCERN: A 26-year-old female patient visited our hospital with no contraindications for dental implants and a loss of the maxillary right first molar. DIAGNOSE: Examination by CBCT demonstrated the posterior maxilla was extremely atrophic, the residual bone height (RBH) of #16 was 3...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29695061/use-of-leukocyte-platelet-l-prf-rich-fibrin-in-diabetic-foot-ulcer-with-osteomyelitis-three-clinical-cases-report
#18
Alessandro Crisci, Giuseppe Marotta, Anna Licito, Edda Serra, Giulio Benincasa, Michela Crisci
In this study, the use of fibrin rich in leukocytes and platelets (L-PRF) was explored to heal osteomyelitis ulcers in a diabetic foot. The goal was to standardize the utilization of L-PRF in patients with osteomyelitis to direct it for healing. L-PRF was obtained autologously from the peripheral blood of the diabetic patients ( n = 3) having osteomyelitis and skin lesions for at least six months. The L-PRF and supernatant serum were inserted into the skin lesion to the bone after a surgical debridement. The evolution of lesions over time was analyzed...
April 24, 2018: Diseases (Basel)
https://www.readbyqxmd.com/read/29691830/stem-cells-in-osteochondral-tissue-engineering
#19
Eleonora Pintus, Matteo Baldassarri, Luca Perazzo, Simone Natali, Diego Ghinelli, Roberto Buda
Mesenchymal stem cells (MSCs) are pluripotent stem cells with the ability to differentiate into a variety of other connective tissue cells, such as chondral, bony, muscular, and tendon tissue. Bone marrow-derived MSCs are pluripotent cells that can differentiate among others into osteoblasts, adipocytes and chondrocytes.Bone marrow-derived cells may represent the future in osteochondral repair. A one-step arthroscopic technique is developed for cartilage repair, using a device to concentrate bone marrow-derived cells and collagen powder or hyaluronic acid membrane as scaffolds for cell support and platelet gel...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29683498/advanced-platelet-rich-fibrin-and-freeze-dried-bone-allograft-for-ridge-preservation-a-randomized-controlled-clinical-trial
#20
Daniel Clark, Yogalakshmi Rajendran, Sarmad Paydar, Sunita Ho, Darren Cox, Mark Ryder, John Dollard, Richard T Kao
BACKGROUND: Advanced platelet-rich fibrin (A-PRF) is an autogenous blood product with applications in dento-alveolar surgery. However, there is minimal information regarding its optimal clinical application or efficacy. The aim of this multi-arm parallel randomized controlled clinical trial was to evaluate the efficacy of A-PRF alone or with freeze-dried bone allograft (FDBA) in improving vital bone formation and alveolar dimensional stability during ridge preservation. METHODS: Forty patients requiring extraction of non-molar teeth and replacement with dental implants were randomized into one of four ridge preservation approaches: A-PRF, A-PRF+FDBA, FDBA, or blood clot...
April 2018: Journal of Periodontology
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