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https://www.readbyqxmd.com/read/28446800/oxidative-stress-evoked-damages-on-rat-sperm-and-attenuated-antioxidant-status-on-consumption-of-aspartame
#1
I Ashok, P S Poornima, D Wankhar, R Ravindran, R Sheeladevi
Although several studies on toxic effect of aspartame metabolite have been studied, controversial reports over the use of aspartame owing to the fact that it releases methanol as one of its metabolite during metabolism exist. This present study is proposed to investigate whether aspartame (40 mg kg(-1) b.wt) administration for 90 days could induce oxidative stress and alter antioxidant status of epididymal sperm in Wistar strain male albino rats. To mimic the human methanol metabolism, methotrexate (MTX)-treated rats were included to study the effects of aspartame...
April 27, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/28407474/the-impact-of-low-and-no-caloric-sweeteners-on-glucose-absorption-incretin-secretion-and-glucose-tolerance
#2
Catherine B Chan, Zohre Hashemi, Fatheema Begum Subhan
The consumption of non-nutritive, low or no-calorie sweeteners (LCS) is increasing globally. Previously thought to be physiologically inert, there is a growing body of evidence that LCS not only provide a sweet taste but may also elicit metabolic effects in the gastrointestinal tract. This review provides a brief overview of the chemical and receptor-binding properties and effects on chemosensation of different LCS but focuses on the extent to which LCS stimulates glucose transport, incretin and insulin secretion, and effects on glucose tolerance...
April 13, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28406689/caloric-primary-rewards-systematically-alter-time-perception
#3
Bowen J Fung, Carsten Murawski, Stefan Bode
Human time perception can be influenced by contextual factors, such as the presence of reward. Yet, the exact nature of the relationship between time perception and reward has not been conclusively characterized. We implemented a novel experimental paradigm to measure estimations of time across a range of suprasecond intervals, during the anticipation and after the consumption of fruit juice, a physiologically relevant primary reward. We show that average time estimations were systematically affected by the consumption of reward, but not by the anticipation of reward...
April 13, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28401812/-listen-to-your-body-participants-alternative-to-science-in-online-health-discussions
#4
Wytske Versteeg, Hedwig Te Molder, Petra Sneijder
We present a discursive psychological analysis of how the idiomatic expression "Listen to Your Body" is deployed in online forum discussions about ADHD medication and aspartame. The Listen to Your Body device allows participants to demonstrate to others that they take their health seriously and for that reason avoid scientific knowledge. They contrast Listen to Your Body with "blindly following science," presenting Listen to Your Body as the more critical and, therefore, more rational behavior. Instead of treating the idiomatic expression as "anyone's knowledge," speakers and recipients compete for the right to own it...
March 1, 2017: Health (London)
https://www.readbyqxmd.com/read/28394643/metabolic-effects-of-aspartame-in-adulthood-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#5
Natalia Cardoso Santos, Laiza Magalhaes de Araujo, Graziela De Luca Canto, Eliete Neves Silva Guerra, Michella Soares Coelho, Maria de Fatima Borin
BACKGROUND: Data about harms or benefits associated with the consumption of aspartame, a non-nutritive sweetener worldwide consumed, is still controversial. This systematic review and meta-analysis of randomized controlled clinical trials aimed to assess the effect of aspartame consumption on metabolic parameters related to diabetes and obesity. METHODS: The search was performed on Cochrane, LILACS, PubMed, SCOPUS, Web of Science databases and on a grey literature using Open Grey, Google Scholar and ProQuest Dissertations & Theses Global...
April 10, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28393871/long-term-consumption-of-sugar-sweetened-beverage-during-the-growth-period-promotes-social-aggression-in-adult-mice-with-proinflammatory-responses-in-the-brain
#6
Jung-Yun Choi, Mi-Na Park, Chong-Su Kim, Young-Kwan Lee, Eun Young Choi, Woo Young Chun, Dong-Mi Shin
Overconsumption of sugar-sweetened beverages (SSBs) is known to be a key contributor to the obesity epidemic; however, its effects on behavioral changes are yet to be fully studied. In the present study, we examined the long-term effects of SSB on social aggression in mice. Three-week-old weaned mice started to drink either a 30 w/v% sucrose solution (S30), plain water (CT), or an aspartame solution with sweetness equivalent to the sucrose solution (A30) and continued to drink until they were 11-week-old adults...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28381800/citric-acid-suppresses-the-bitter-taste-of-olopatadine-hydrochloride-orally-disintegrating-tablets
#7
Mai Sotoyama, Shinya Uchida, Shimako Tanaka, Akio Hakamata, Keiichi Odagiri, Naoki Inui, Hiroshi Watanabe, Noriyuki Namiki
Orally disintegrating tablets (ODTs) are formulated to disintegrate upon contact with saliva, allowing administration without water. Olopatadine hydrochloride, a second-generation antihistamine, is widely used for treating allergic rhinitis. However, it has a bitter taste; therefore, the development of taste-masked olopatadine ODTs is essential. Some studies have suggested that citric acid could suppress the bitterness of drugs. However, these experiments were performed using solutions, and the taste-masking effect of citric acid on ODTs has not been evaluated using human gustatory sensation tests...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28378852/effects-of-non-nutritive-artificial-vs-natural-sweeteners-on-24-h-glucose-profiles
#8
S L Tey, N B Salleh, C J Henry, C G Forde
Replacing nutritive sweetener with non-nutritive sweeteners (NNS) has the potential to improve glycaemic control. The objective of this study was to investigate the effects of consuming artificial NNS (that is, aspartame), natural NNS (that is, monk fruit and stevia), and sucrose-sweetened beverages on 24-h glucose profiles. Ten healthy males took part in this randomised, crossover study with the following four treatments: aspartame-, monk fruit-, stevia-, and sucrose- (65 g) sweetened beverages. Participants were asked to consume the test beverage as a preload mid-morning...
April 5, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28370108/a-preliminary-study-on-the-application-of-natural-sweet-proteins-in-agar-based-gels
#9
Nicoletta A Miele, Rossella Di Monaco, Francesca Dell'Amura, Michele F Rega, Delia Picone, Silvana Cavella
Natural sweet proteins may be used as sugar replacer in simple liquid food systems but their applicability in more complex matrices has not been investigated yet. Gelling agent nature and texture characteristics as well as type and distribution of a stimulus in a gel could affect taste perception through inhibition or enhancement of tastants migration to the receptors. The mechanical, nonoral texture and time-intensity sweetness characteristics of sweet proteins MNEI and super sweet Y65R mutant, aspartame and saccharin added at a concentration iso-sweet to 40 g/L of sucrose in three agar gel concentrations (1%, 1...
April 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28334357/sweetener-intake-by-rats-selectively-bred-for-differential-saccharin-intake-sucralose-stevia-and-acesulfame-potassium
#10
Nancy K Dess, Kiana Dobson, Brandon T Roberts, Clinton D Chapman
Behavioral responses to sweeteners have been used to study the evolution, mechanisms, and functions of taste. Occidental low and high saccharin consuming rats (respectively, LoS and HiS) have been selectively outbred on the basis of saccharin intake and are a valuable tool for studying variation among individuals in sweetener intake and its correlates. Relative to HiS rats, LoS rats consume smaller amounts of all nutritive and nonnutritive sweeteners tested to date, except aspartame. The lines also differ in intake of the commercial product Splenda; the roles of sucralose and saccharides in the difference are unclear...
March 15, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28334211/effect-of-sweeteners-on-the-survival-of-solenopsis-invicta-hymenoptera-formicidae
#11
Xiaoqiang Zhang, Siqi Chen, Zhiqiang Li, Yijuan Xu
The red imported fire ant, Solenopsis invicta Buren, is a serious agricultural, ecological, and public health pest in its invaded range. Chemical insecticides have been widely used for the prevention and control of this notorious pest. To search for novel, cost-effective, and environmentally friendly materials for fire ant control, we tested various sweeteners for their toxicity to S. invicta. The S. invicta that were fed erythritol, aspartame, and saccharin exhibited significantly higher mortality rates than those fed other sweeteners...
April 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28317386/hepatoprotective-effect-of-blocking-n-methyl-d-aspartate-receptors-in-male-albino-rats-exposed-to-acute-and-repeated-restraint-stress
#12
Shaimaa Nasr Amin, Ahmed Amro El-Aidi, Maha Baligh Zickri, Laila Ahmed Rashed, Sherif Sabry Hassan
Stress affects many organs in addition to the brain, including the liver. We assessed the effects on the liver of blocking N-methyl-d-aspartate (NMDA) glutamate receptors with memantine in acute and repeated restraint stress. Forty-two male albino rats were divided into 7 groups; control, acute restraint stress (ARS), ARS + memantine, repeated restraint stress, repeated restraint + memantine, and positive control groups. We measured serum iron, zinc, alanine transferase and aspartame transferase, hepatic malondialdehyde, tumor necrosis factor-α (TNF-α), glutathione peroxidase, superoxide dismutase, metallothionein content, zinc transporter ZRT/IRT-like protein 14 mRNA expression, and hepcidin expression...
March 18, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28298151/effect-of-exclusion-of-frequently-consumed-dietary-triggers-in-a-cohort-of-children-with-chronic-primary-headache
#13
Sepideh Taheri
BACKGROUND: Although dietary factors are known to trigger headaches, the relationship between food and headache in children remains unclear. This prospective, observational case series aimed to evaluate the effect of exclusion of frequently-consumed foods in a cohort of children with headache. METHODS: One hundred and fifteen children aged 3-15 (mean 10.5) years with primary headache were followed in a paediatric outpatient clinic. Patients who frequently consumed foods or food additives known to trigger headaches were advised to exclude them for six weeks and to return for follow-up with headache and food diary...
March 2017: Nutrition and Health
https://www.readbyqxmd.com/read/28277180/simultaneous-determination-of-sodium-saccharin-aspartame-acesulfame-k-and-sucralose-in-food-consumed-in-korea-using-high-performance-liquid-chromatography-and-evaporative-light-scattering-detection
#14
Youngsun Lee, Byungkyung Do, Gunyoung Lee, Ho Soo Lim, Sang Soon Yun, Hoonjeong Kwon
Four artificial sweeteners, i.e., sodium saccharin, aspartame, acesulfame-K and sucralose, are permitted for use in Korea, and recent regulatory changes have expanded the number of food categories in which they may be used. Four artificial sweeteners were determined simultaneously in more than 900 food items from 30 food categories that are commercially available in Korean markets, including both domestic and imported products, using high-performance liquid chromatography and evaporative light-scattering detection (ELSD)...
February 17, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28254270/silymarin-attenuates-aspartame-induced-variation-in-mouse-behaviour-cerebrocortical-morphology-and-oxidative-stress-markers
#15
Yetunde Onaolapo Adejoke, Zayid Abdusalam Saratu, James Onaolapo Olakunle
OBJECTIVE: We assessed the impacts of silymarin co-administration on aspartame-induced changes in novelty-induced behaviours, memory, anxiety-related behaviours, cerebral antioxidant status and histomorphology in mice. METHOD: Six groups of mice were administered vehicle (distilled water), silymarin (25mg/kg), aspartame (at 160 or 320mg/kg), and silymarin (25mg/kg) co-administered with aspartame at 160 or 320mg/kg daily for 21days, via an oral cannula. Behaviours were assessed after the first and last dose of treatment...
February 15, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28198207/neurophysiological-symptoms-and-aspartame-what-is-the-connection
#16
Arbind Kumar Choudhary, Yeong Yeh Lee
Aspartame (α-aspartyl-l-phenylalanine-o-methyl ester), an artificial sweetener, has been linked to behavioral and cognitive problems. Possible neurophysiological symptoms include learning problems, headache, seizure, migraines, irritable moods, anxiety, depression, and insomnia. The consumption of aspartame, unlike dietary protein, can elevate the levels of phenylalanine and aspartic acid in the brain. These compounds can inhibit the synthesis and release of neurotransmitters, dopamine, norepinephrine, and serotonin, which are known regulators of neurophysiological activity...
February 15, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28191319/discrimination-of-enantiomers-of-dipeptide-derivatives-with-two-chiral-centers-by-tetraaza-macrocyclic-chiral-solvating-agents-using-1-h-nmr-spectroscopy
#17
Lixia Fang, Caixia Lv, Guo Wang, Lei Feng, Pericles Stavropoulos, Guangpeng Gao, Lin Ai, Jiaxin Zhang
(1)H NMR spectroscopy is often used to discriminate enantiomers of chiral analytes and determine their enantiomeric excess (ee) by various chiral auxiliaries. In reported research, these studies were mainly focused on chiral discriminantion of chiral analytes with only one chiral center. However, many chiral compounds possessing two or more chiral centers are often found in natural products, chiral drugs, products of asymmetric synthesis and biological systems. Therefore, it is necessary to investigate their chiral discrimination by effective chiral auxiliaries using (1)H NMR spectroscopy...
December 1, 2016: Organic Chemistry Frontiers: An International Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28187322/chronic-aspartame-intake-causes-changes-in-the-trans-sulphuration-pathway-glutathione-depletion-and-liver-damage-in-mice
#18
Isabela Finamor, Salvador Pérez, Caroline A Bressan, Carlos E Brenner, Sergio Rius-Pérez, Patricia C Brittes, Gabriele Cheiran, Maria I Rocha, Marcelo da Veiga, Juan Sastre, Maria A Pavanato
No-caloric sweeteners, such as aspartame, are widely used in various food and beverages to prevent the increasing rates of obesity and diabetes mellitus, acting as tools in helping control caloric intake. Aspartame is metabolized to phenylalanine, aspartic acid, and methanol. Our aim was to study the effect of chronic administration of aspartame on glutathione redox status and on the trans-sulphuration pathway in mouse liver. Mice were divided into three groups: control; treated daily with aspartame for 90 days; and treated with aspartame plus N-acetylcysteine (NAC)...
April 2017: Redox Biology
https://www.readbyqxmd.com/read/28157063/safe-excipient-exposure-in-neonates-and-small-children-protocol-for-the-seen-project
#19
Kristine Svinning Valeur, Steen Axel Hertel, Kaare Engell Lundstrøm, Helle Holst
INTRODUCTION: The pharmacokinetics of excipients in neonates differs from that of older children. In a recent pan--European survey, two thirds of neonates received at least one potentially harmful excipient, such as ethanol and benzoates. The content of sweeteners varied by route of administration (more common by enteral than parenteral route), and regional differences were revealed. The survey did not identify if the content of excipients was more pronounced in medications prescribed for specific medical diseases, e...
February 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28150114/a-theoretical-and-experimental-study-of-calcium-iron-zinc-cadmium-and-sodium-ions-absorption-by-aspartame
#20
Karim Mahnam, Fatame Raisi
Aspartame (L-Aspartyl-L-phenylalanine methyl ester) is a sweet dipeptide used in some foods and beverages. Experimental studies show that aspartame causes osteoporosis and some illnesses, which are similar to those of copper and calcium deficiency. This raises the issue that aspartame in food may interact with cations and excrete them from the body. This study aimed to study aspartame interaction with calcium, zinc, iron, sodium, and cadmium ions via molecular dynamics simulation (MD) and spectroscopy. Following a 480-ns molecular dynamics simulation, it became clear that the aspartame is able to sequester Fe(2+), Ca(2+), Cd(2+), and Zn(2+) ions for a long time...
March 2017: Journal of Biological Physics
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