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https://www.readbyqxmd.com/read/29787679/dynamic-proteome-alteration-and-functional-modulation-of-human-saliva-induced-by-dietary-chemosensory-stimuli
#1
Matthias Bader, Andreas Dunkel, Mareike Wenning, Bernd Kohler, Guillaume Medard, Estela Del Castillo, Amin Gholami, Bernhard Kuster, Siegfried Scherer, Thomas Hofmann
Saliva flow measurements and SDS-PAGE separation of human whole saliva freshly collected after oral stimulation with citric acid (sour), aspartame (sweet), iso-α-acids (bitter), mono sodium L-glutamate (umami), NaCl (salty), 6-gingerol (pungent), hydroxy-α-sanshool (tingling), and hydroxy-β-sanshool (numbing), followed by tryptic digestion, nano-HPLC-MS/MS, and label-free protein quantitation demonstrated a stimulus- and time-dependent influence of the dietary chemosensates on salivation and the salivary proteome composition...
May 22, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29761610/pathways-and-mechanisms-linking-dietary-components-to-cardiometabolic-disease-thinking-beyond-calories
#2
REVIEW
K L Stanhope, M I Goran, A Bosy-Westphal, J C King, L A Schmidt, J-M Schwarz, E Stice, A C Sylvetsky, P J Turnbaugh, G A Bray, C D Gardner, P J Havel, V Malik, A E Mason, E Ravussin, M Rosenbaum, J A Welsh, C Allister-Price, D M Sigala, M R C Greenwood, A Astrup, R M Krauss
Calories from any food have the potential to increase risk for obesity and cardiometabolic disease because all calories can directly contribute to positive energy balance and fat gain. However, various dietary components or patterns may promote obesity and cardiometabolic disease by additional mechanisms that are not mediated solely by caloric content. Researchers explored this topic at the 2017 CrossFit Foundation Academic Conference 'Diet and Cardiometabolic Health - Beyond Calories', and this paper summarizes the presentations and follow-up discussions...
May 14, 2018: Obesity Reviews: An Official Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29760482/glycemic-impact-of-non-nutritive-sweeteners-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#3
Alexander D Nichol, Maxwell J Holle, Ruopeng An
BACKGROUND/OBJECTIVES: Nonnutritive sweeteners (NNSs) are zero- or low-calorie alternatives to nutritive sweeteners, such as table sugars. A systematic review and meta-analysis of randomized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs. SUBJECTS/METHODS: PubMed and Web of Science databases were searched. Two authors screened the titles and abstracts of candidate publications. The third author was consulted to resolve discrepancies...
May 15, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29756702/non-nutritive-sweeteners-children-and-adolescent-consumption-and-food-sources
#4
María B Garavaglia, Vanesa Rodríguez García, María E Zapata, Alicia Rovirosa, Verónica González, Florencia Flax Marcó, Esteban Carmuega
The availability of food and beverages with non-nutritive sweeteners (NNSs) has increased in recent years. OBJECTIVES: To estimate NNSs consumption among children and adolescents in the Autonomous City of Buenos Aires, the prevalence of a daily intake higher than acceptable, and the main food and beverages contributing to it. MATERIAL AND METHODS: Descriptive study about the information collected in the First Food and Nutritional/Nutrition Survey of Buenos Aires City, which was conducted in 2011 and included 2664 children and adolescents aged 2-18 years...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29660810/sensory-profile-drivers-of-liking-and-influence-of-information-on-the-acceptance-of-low-calorie-synbiotic-and-probiotic-chocolate-ice-cream
#5
Juliana Peres, Erick Esmerino, Alessandra Lins da Silva, Ilana Racowski, Helena Bolini
The objective of this study was to evaluate the sensory profile and the influence of the information on the acceptance of the symbiotic chocolate ice cream made with sucrose and different sweeteners (aspartame, sucralose, neotame, Stevia with 60%, 85%, 95%, and 97% of rebaudioside A) through analysis of variance (ANOVA), Tukey's test, and partial least of square (PLS) regression. Quantitative descriptive analysis (QDA) was carried out by 18 assessors, who evaluated the samples in relation to the raised descriptors...
April 16, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29660801/evaluation-of-long-term-effects-of-artificial-sweeteners-on-rat-brain-a-biochemical-behavioral-and-histological-study
#6
Oytun Erbaş, Mümin Alper Erdoğan, Asghar Khalilnezhad, Volkan Solmaz, Fulya Tuzcu Gürkan, Gürkan Yiğittürk, Hüseyin Avni Eroglu, Dilek Taskiran
The aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group (n = 6) received regular tap water, whereas other groups received aspartame (3 mg/kg/day, n = 6,) or saccharin (3 mg/kg/day, n = 6) or sucralose (1.5 mg/kg/day, n = 6) in the drinking water. Following 6 weeks, the passive avoidance learning (PAL) test was performed to evaluate the neurobehavioral effects of sweeteners...
April 16, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29659969/aspartame-consumption-for-12-weeks-does-not-affect-glycemia-appetite-or-body-weight-of-healthy-lean-adults-in-a-randomized-controlled-trial
#7
Kelly A Higgins, Robert V Considine, Richard D Mattes
Background: Low-calorie sweeteners are often used to moderate energy intake and postprandial glycemia, but some evidence indicates that they may exacerbate these aims. Objective: The trial's primary aim was to assess the effect of daily aspartame ingestion for 12 wk on glycemia. Effects on appetite and body weight were secondary aims. Methods: One hundred lean [body mass index (kg/m2): 18-25] adults aged 18-60 y were randomly assigned to consume 0, 350, or 1050 mg aspartame/d (ASP groups) in a beverage for 12 wk in a parallel-arm design...
April 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29621577/six-months-exposure-to-a-real-life-mixture-of-13-chemicals-below-individual-noaels-induced-non-monotonic-sex-dependent-biochemical-and-redox-status-changes-in-rats
#8
Anca Oana Docea, Eliza Gofita, Marina Goumenou, Daniela Calina, Otilia Rogoveanu, Marius Varut, Cristian Olaru, Efthalia Kerasioti, Polyxeni Fountoucidou, Ioannis Taitzoglou, Ovidiu Zlatian, Valerii N Rakitskii, Antonio F Hernandez, Dimitrios Kouretas, Aristidis Tsatsakis
This study assessed the potential adverse health effects of long-term low-dose exposure to chemical mixtures simulating complex real-life human exposures. Four groups of Sprague Dawley rats were administered mixtures containing carbaryl, dimethoate, glyphosate, methomyl, methyl parathion, triadimefon, aspartame, sodium benzoate, calcium disodium ethylene diamine tetra-acetate, ethylparaben, butylparaben, bisphenol A, and acacia gum at doses of 0, 0.25, 1 or 5 times the respective Toxicological Reference Values (TRV): acceptable daily intake (ADI) or tolerable daily intake (TDI) in a 24 weeks toxicity study...
April 2, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29601264/associations-between-nonnutritive-sweetener-intake-and-metabolic-syndrome-in-adults
#9
Erica L Hess, Emily A Myers, Susan E Swithers, Valisa E Hedrick
OBJECTIVE: Individuals looking to improve their health or weight status often use nonnutritive sweeteners (NNS), yet NNS consumption has been associated with increased risk factors for metabolic syndrome (MetS). Most studies examining NNS only assess total intake using diet soda as a proxy for NNS consumption, without distinguishing potential risks associated with individual sweeteners. The objective of this cross-sectional investigation was to identify whether there were associations between NNS consumption (total or individual) and risk factors for MetS in adults (n = 125) from Southwest Virginia...
March 30, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29597305/effects-of-consuming-a-low-dose-of-alcohol-with-mixers-containing-carbohydrate-or-artificial-sweetener-on-simulated-driving-performance
#10
Bryce Brickley, Ben Desbrow, Danielle McCartney, Christopher Irwin
The Australian National Drug and Alcohol Research Centre (NDARC) devised gender-based drinking recommendations to ensure blood or equivalized breath alcohol concentrations (BrAC) remain <0.050%. However, these may be inappropriate for individuals consuming alcohol without carbohydrate (CHO), which results in higher BrACs. This study investigated the effects of ingesting alcohol with and without CHO on BrACs and simulated driving performance. Thirty-two participants (16 males; age: 23 ± 6 years) completed two randomized single-blinded trials...
March 28, 2018: Nutrients
https://www.readbyqxmd.com/read/29567262/oxidative-stress-evoked-damages-leading-to-attenuated-memory-and-inhibition-of-nmdar-camkii-erk-creb-signalling-on-consumption-of-aspartame-in-rat-model
#11
Ashok Iyaswamy, Ananth Kumar Kammella, Citarasu Thavasimuthu, Wankhar Wankupar, Wankhar Dapkupar, Sambantham Shanmugam, Ravindran Rajan, Sheeladevi Rathinasamy
Many controversial reports are available on the use of aspartame as it releases methanol as one of its metabolite during metabolism. The present study proposes to investigate whether long term (90 days) aspartame (40 mg/kg b.wt) administration could induce oxidative stress and alter the memory in Wistar strain male albino rats. To mimic the human methanol metabolism, methotrexate (MTX)-treated rats were included as a model to study the effects of aspartame. Wistar strain albino rats were administered with aspartame (40 mg/kg b...
April 2018: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/29561882/effect-of-developmental-nmdar-antagonism-with-cgp-39551-on-aspartame-induced-hypothalamic-and-adrenal-gene-expression
#12
Kate S Collison, Angela Inglis, Sherin Shibin, Soad Saleh, Bernard Andres, Rosario Ubungen, Jennifer Thiam, Princess Mata, Futwan A Al-Mohanna
RATIONALE: Aspartame (L-aspartyl phenylalanine methyl ester) is a non-nutritive sweetener (NNS) approved for use in more than 6000 dietary products and pharmaceuticals consumed by the general public including adults and children, pregnant and nursing mothers. However a recent prospective study reported a doubling of the risk of being overweight amongst 1-year old children whose mothers consumed NNS-sweetened beverages daily during pregnancy. We have previously shown that chronic aspartame (ASP) exposure commencing in utero may detrimentally affect adulthood adiposity status, glucose metabolism and aspects of behavior and spatial cognition, and that this can be modulated by developmental N-methyl-D-aspartate receptor (NMDAR) blockade with the competitive antagonist CGP 39551 (CGP)...
2018: PloS One
https://www.readbyqxmd.com/read/29546409/corrigendum-for-revisiting-the-safety-of-aspartame-by-arbind-kumar-choudhary-and-etheresia-pretorius-nutrition-reviews-2017-75-9-718-730
#13
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29543782/low-no-calorie-sweeteners-a-review-of-global-intakes
#14
REVIEW
Danika Martyn, Maryse Darch, Ashley Roberts, Han Youl Lee, Tina Yaqiong Tian, Naoko Kaburagi, Pablo Belmar
The current review examined published data on the intake of all major low-/no-calorie sweeteners-aspartame, acesulfame-K, saccharin, sucralose, cyclamate, thaumatin and steviol glycosides-globally over the last decade. The most detailed and complex exposure assessments were conducted in Europe, following a standardized approach. Japan and Korea similarly had up-to-date and regular intake data available. The data for other Asian countries, Latin America, Australia/New Zealand and global estimates, evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), while available, were shown to be more limited in terms of design...
March 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29534454/the-comparative-reproducibility-and-validity-of-a-non-nutritive-sweetener-food-frequency-questionnaire
#15
Emily A Myers, Erin M Passaro, Valisa E Hedrick
In order to better assess non-nutritive sweetener (NNS) consumption, measurement tools with greater utility are needed. The objective of this investigation is to determine the reproducibility and validity of a newly developed NNS food frequency questionnaire (NNS-FFQ) that measures five types of NNS (saccharin, aspartame, acesulfame potassium, sucralose and erythritol). Adult participants ( n = 123, 56% female, 75% Caucasian, mean age = 36.8 ± 16.6) completed the NNS-FFQ twice and had 24-h dietary recalls three times over a two-week study period...
March 10, 2018: Nutrients
https://www.readbyqxmd.com/read/29511682/noncaloric-sweeteners-in-children-a-controversial-theme
#16
REVIEW
Samuel Durán Agüero, Lissé Angarita Dávila, Ma Cristina Escobar Contreras, Diana Rojas Gómez, Jorge de Assis Costa
Noncaloric sweeteners (NCS) are food additives used to provide sweetness without adding calories. Their consumption has become more widespread around the world in all age groups, including children. The aim of this study is to show the state of the art about the intake of noncaloric sweeteners in children, as well as their benefits and consumption risk. Scientific searchers were used (PUBMED, Scopus, and Scielo) to analyze articles that included keywords (noncaloric sweeteners/saccharin/cyclamate/acesulfame potassium/aspartame/sucralose/stevia/children) in English, Spanish, and Portuguese...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29504081/analysis-of-a-variety-of-inorganic-and-organic-additives-in-food-products-by-ion-pairing-liquid-chromatography-coupled-to-high-resolution-mass-spectrometry
#17
Anton Kaufmann, Mirjam Widmer, Kathryn Maden, Patrick Butcher, Stephan Walker
A reversed-phase ion-pairing chromatographic method was developed for the detection and quantification of inorganic and organic anionic food additives. A single-stage high-resolution mass spectrometer (orbitrap ion trap, Orbitrap) was used to detect the accurate masses of the unfragmented analyte ions. The developed ion-pairing chromatography method was based on a dibutylamine/hexafluoro-2-propanol buffer. Dibutylamine can be charged to serve as a chromatographic ion-pairing agent. This ensures sufficient retention of inorganic and organic anions...
March 5, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29502835/enhancement-of-z-aspartame-synthesis-by-rational-engineering-of-metalloprotease
#18
Fucheng Zhu, Tianyue Jiang, Bin Wu, Bingfang He
Metalloprotease PT121Y114S , an effective catalyst for Z-aspartame synthesis under the substrate (Z-Asp:l-Phe-OMe) molar ratio of 1:5, was obtained previously. Herein, a computational strategy combining molecular dynamics simulation of the enzyme-substrate complex with binding free energy (ΔG) calculations was established to guide the further engineering of PT121Y114S . One His224 residue proximal to the PT121Y114S active site was selected on the basis of the difference in ΔG decomposition of PT121Y114S toward l-Phe-NH2 and l-Phe-OMe...
July 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29502834/effects-of-polyol-type-and-particle-size-on-flavor-release-in-chewing-gum
#19
Smita Raithore, Devin G Peterson
The influence of polyol type and particle size on the flavor release profile of chewing gum was investigated in vivo. Four chewing gum samples with an average particle size of 62 or 246 μm for sorbitol and 57 or 184 μm for mannitol were analyzed. Chewing gum formulated with mannitol, in general, had a higher aroma release than chewing gum formulated with sorbitol. Polyol type did not influence the release profile of the high intensity sweeteners (HIS) aspartame and acesulfame K. However, a smaller particle size resulted in a significantly higher release of HIS...
July 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29482444/the-possible-protective-effect-of-n-acetyl-l-cysteine-and-folic-acid-in-combination-against-aspartame-induced-cerebral-cortex-neurotoxicity-in-adult-male-rats-a-light-and-transmission-electron-microscopic-study
#20
Hala F Abd-Ellah, Nadia R A Abou-Zeid, Nadia M Nasr
The purpose of this study is to investigate structural and ultrastructural alterations in the rat's brain cerebral cortex after aspartame (ASP) treatment and to evaluate the possible ameliorating role of N-acetyl-L-cysteine (NAC) and folic acid (FA). Forty adult rats were divided into four equal groups: Group I, received appropriate vehicle only and served as control. Group II, received oral doses of both NAC (600 mg/kg body weight (b.w.)) and FA (12 mg/kg b.w.) daily for 42 days. Group III, received oral doses of ASP (500 mg/kg b...
February 26, 2018: Ultrastructural Pathology
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