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https://www.readbyqxmd.com/read/28335329/nanoparticle-based-delivery-of-anaplasma-marginale-membrane-proteins-virb9-1-and-virb10-produced-in-the-pichia-pastoris-expression-system
#1
Bing Zhang, Antonio S Cavallaro, Karishma T Mody, Jun Zhang, James R Deringer, Wendy C Brown, Timothy J Mahony, Chengzhong Yu, Neena Mitter
Bovine anaplasmosis or cattle-tick fever is a tick-borne haemolytic disease caused by the rickettsial haemoparasite Anaplasma marginale in tropical and subtropical areas of the world. While difficult to express, the proteins VirB9-1 and VirB10 are immunogenic components of the outer membrane type IV secretion system that have been identified as candidate antigens for vaccines targeting of A. marginale. Soluble VirB9-1 and VirB10 were successfully expressed using Pichia pastoris. When formulated with the self-adjuvanting silica vesicles, SV-100 (diameter: 50 nm, and pore entrance size: 6 nm), 200 µg of VirB9-1 and VirB10 were adsorbed per milligram of nanoparticle...
November 5, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28333400/an-improved-model-of-the-trypanosoma-brucei-ctp-synthetase-glutaminase-domain-acivicin-complex
#2
Juliana Oliveira de Souza, Alice Dawson, William Nigel Hunter
The natural product acivicin inhibits the glutaminase activity of CTP synthetase and is a potent lead compound for drug discovery in the area of neglected tropical diseases, specifically trypanosomaisis. A 2.1 Å resolution crystal structure of the acivicin adduct with the glutaminase domain from Trypanosoma brucei CTP synthetase has been deposited in the Protein Data Bank and provides a template for structure-based approaches to design new inhibitors. However, our assessment of that data identified deficiencies in the model...
March 23, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28333074/assessment-of-the-anti-hyperglycaemic-anti-inflammatory-and-antioxidant-activities-of-the-methanol-extract-of-moringa-oleifera-in-diabetes-induced-nephrotoxic-male-wistar-rats
#3
Elizabeth I Omodanisi, Yapo G Aboua, Oluwafemi O Oguntibeju
Diabetes mellitus is an endocrine disease of multiple aetiologies in insulin secretion. A deficiency in insulin results in hyperglycemia with metabolic disturbances of biomolecules. Moringa oleifera (MO) is endemic in the tropics with a variety of ethnomedicinal importance. The leaf of this plant has been reported to possess antioxidant and medicinal properties that may be helpful in the treatment and management of diabetes and its associated complications. Diabetes was induced intraperitoneally in rats by a single dose of streptozotocin (55 mg/kg) and treated with methanolic extract of Moringa oleifera (250 mg/kg b...
March 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28332127/a-review-of-zoonotic-infection-risks-associated-with-the-wild-meat-trade-in-malaysia
#4
REVIEW
Jennifer Caroline Cantlay, Daniel J Ingram, Anna L Meredith
The overhunting of wildlife for food and commercial gain presents a major threat to biodiversity in tropical forests and poses health risks to humans from contact with wild animals. Using a recent survey of wildlife offered at wild meat markets in Malaysia as a basis, we review the literature to determine the potential zoonotic infection risks from hunting, butchering and consuming the species offered. We also determine which taxa potentially host the highest number of pathogens and discuss the significant disease risks from traded wildlife, considering how cultural practices influence zoonotic transmission...
March 22, 2017: EcoHealth
https://www.readbyqxmd.com/read/28331264/tropical-pyomyositis-revisited
#5
V Manikandan, Sandeep Mehrotra, Sunil Anand, Vinay Maurya
Since the initial description of tropical pyomyositis 130 years ago, this disease continues to retain some mystery for physicians and surgeons. The infrequency, variable epidemiologic and demographic profile, diagnostic dilemmas and limited literature continue to make it an enigma with limited understanding. In the span of nearly 130 years, worldwide English literature search has revealed an average of only two to three reported cases every year globally. We recently managed a case of tropical pyomyositis which posed a clinical and radiologic diagnostic dilemma...
February 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28331180/ccr5-promoter-activity-correlates-with-hiv-disease-progression-by-regulating-ccr5-cell-surface-expression-and-cd4-t-cell-apoptosis
#6
Anjali Joshi, Erin B Punke, Melina Sedano, Bethany Beauchamp, Rima Patel, Cassady Hossenlopp, Ogechika K Alozie, Jayanta Gupta, Debabrata Mukherjee, Himanshu Garg
CCR5 is the major co-receptor for HIV and polymorphisms in the CCR5 gene as well as promoter region that alter cell surface expression have been associated with disease progression. We determined the relationship between CCR5 promoter polymorphisms and CD4 decline and other immunopathological features like immune activation and CD4+ T cell apoptosis in HIV patients. CCR5 promoter haplotype HHC was significantly associated with higher CD4 counts in patients. The relative promoter activity (RPA) of each haplotype was determined in vitro and combined promoter activity based on both alleles (CRPA) was assigned to each patients...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28330495/building-a-global-schistosomiasis-alliance-an-opportunity-to-join-forces-to-fight-inequality-and-rural-poverty
#7
Lorenzo Savioli, Marco Albonico, Daniel G Colley, Rodrigo Correa-Oliveira, Alan Fenwick, Will Green, Narcis Kabatereine, Achille Kabore, Naftale Katz, Katharina Klohe, Philip T LoVerde, David Rollinson, J Russell Stothard, Louis-Albert Tchuem Tchuenté, Johannes Waltz, Xiao-Nong Zhou
Schistosomiasis, one of the 17 neglected tropical diseases listed by the World Health Organization, presents a substantial public health and economic burden. Of the 261 million people requiring preventive chemotherapy for schistosomiasis in 2013, 92% of them lived in sub-Saharan Africa and only 12.7% received preventive chemotherapy. Moreover, in 2010, the WHO reported that schistosomiasis mortality could be as high as 280 000 per year in Africa alone.In May 2012 delegates to the sixty-fifth World Health Assembly adopted resolution WHA65...
March 23, 2017: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/28330228/development-of-novel-ssr-markers-for-evaluation-of-genetic-diversity-and-population-structure-in-tribulus-terrestris-l-zygophyllaceae
#8
Kuljit Kaur, Vikas Sharma, Vijay Singh, Mohammad Saleem Wani, Raghbir Chand Gupta
Tribulus terrestris L., commonly called puncture vine and gokhru, is an important member of Zygophyllaceae. The species is highly important in context to therapeutic uses and provides important active principles responsible for treatment of various diseases and also used as tonic. It is widely distributed in tropical regions of India and the world. However, status of its genetic diversity remained concealed due to lack of research work in this species. In present study, genetic diversity and structure of different populations of T...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329123/prevalence-of-chagas-disease-in-the-latin-american-born-population-of-los-angeles
#9
Sheba K Meymandi, Colin J Forsyth, Jonathan Soverow, Salvador Hernandez, Daniel Sanchez, Susan P Montgomery, Mahmoud Traina
Background.: According to an estimate from the Centers for Disease Control and Prevention (CDC), Chagas disease (CD) may affect 1.31% of Latin American immigrants in the United States, with >300 000 cases. However, there is a lack of real-world data to support this estimate. Little is known about the actual prevalence of this neglected tropical disease in the United States, and the bulk of those infected are undiagnosed. Methods.: From April 2008 to May 2014, we screened 4,755 Latin American-born residents of Los Angeles County...
February 12, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28327802/in-vitro-and-in-vivo-antileishmanial-activity-of-artemisia-annua-l-leaf-powder-and-its-potential-usefulness-in-the-treatment-of-uncomplicated-cutaneous-leishmaniasis-in-humans
#10
Luz Estella Mesa, Daniel Vasquez, Pierre Lutgen, Iván Darío Vélez, Adriana María Restrepo, Isabel Ortiz, Sara María Robledo
INTRODUCTION: Cutaneous leishmaniasis (CL) is a tropical disease that affects millions of individuals worldwide. The current drugs for CL may be effective but have serious side effects; hence, alternatives are urgently needed. Although plant-derived materials are used for the treatment of various diseases in 80% of the global population, the validation of these products is essential. Gelatin capsules containing dried Artemisia annua leaf powder were recently developed as a new herbal formulation (totum) for the oral treatment of malaria and other parasitic diseases...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28327792/vegetation-loss-and-the-2016-oropouche-fever-outbreak-in-peru
#11
Daniel Romero-Alvarez, Luis E Escobar
BACKGROUND: Oropouche virus causes Oropouche fever, an arboviral disease transmitted mainly by midges of the genus Culicoides and Culex mosquitoes. Clinical presentation of Oropouche fever in humans includes fever, headache, rash, myalgia, and in rare cases spontaneous bleeding and aseptic meningitis. Landscape change has been proposed as a driver of Oropouche fever emergence. OBJECTIVE: To investigate the landscape epidemiology of the Oropouche fever outbreak that began in April 2016 in Cusco, Peru...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28327791/a-tale-of-two-neglected-tropical-infections-using-gis-to-assess-the-spatial-and-temporal-overlap-of-schistosomiasis-and-leprosy-in-a-region-of-minas-gerais-brazil
#12
David Alexander Phillips, José Antonio Ferreira, Deidra Ansah, Herica Sa Teixeira, Uriel Kitron, Thelma de Filippis, Marcelo H de Alcântara, Jessica K Fairley
BACKGROUND: Despite public health efforts to reduce the global burden of leprosy, gaps remain in the knowledge surrounding transmission of infection. Helminth co-infections have been associated with a shift towards the lepromatous end of the disease spectrum, potentially increasing transmission in co-endemic areas. OBJECTIVES: Using this biologically plausible association, we conducted a geographic information systems (GIS) study to investigate the spatial associations of schistosomiasis and leprosy in an endemic area of Minas Gerais (MG), Brazil...
April 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28325371/the-role-of-spatial-statistics-in-the-control-and-elimination-of-neglected-tropical-diseases-in-sub-saharan-africa-a-focus-on-human-african-trypanosomiasis-schistosomiasis-and-lymphatic-filariasis
#13
M C Stanton
Disease control and elimination programmes can benefit greatly from accurate information on the spatial variability of disease risk, particularly when risk is highly spatially heterogeneous. Due to advances in statistical methodology, coupled with the increased availability of geospatial technology, this information is becoming increasingly accessible. In this chapter we describe recent advancements in spatial methods associated with the analysis of disease data measured at the point-level and demonstrate their application to the control and elimination of neglected tropical diseases (NTDs)...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28320726/glucantime%C3%A2-causes-oxidative-stress-derived-dna-damage-in-balb-c-mice-infected-by-leishmania-leishmania-infantum
#14
Vanessa Ribeiro Moreira, Luís Cláudio Lima de Jesus, Rossy-Eric Pereira Soares, Luis Douglas Miranda Silva, Bruno Araújo Serra Pinto, Maria Norma Melo, Antonio Marcus de Andrade Paes, Silma Regina Ferreira Pereira
Leishmaniasis is a neglected tropical disease caused by over 20 species of the protozoan parasite Leishmania Regarding treatment, Glucantime® is the first-choice drug recommended by the World Health Organization for the treatment of all types of leishmaniasis. However, the mechanisms of action and toxicity of pentavalent antimonials, including genotoxic effetcs, remain unclear. Therefore, the mechanism by which Glucantime® causes DNA damage was investigated in BALB/c mice infected by Leishmania (Leishmania) infantum and treated with Glucantime® (20 mg/kg for 20 days)...
March 20, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28319196/h-channels-in-embryonic-biomphalaria-glabrata-cell-membranes-putative-roles-in-snail-host-schistosome-interactions
#15
Brandon J Wright, Utibe Bickham-Wright, Timothy P Yoshino, Meyer B Jackson
The human blood fluke Schistosoma mansoni causes intestinal schistosomiasis, a widespread neglected tropical disease. Infection of freshwater snails Biomphalaria spp. is an essential step in the transmission of S. mansoni to humans, although the physiological interactions between the parasite and its obligate snail host that determine success or failure are still poorly understood. In the present study, the B. glabrata embryonic (Bge) cell line, a widely used in vitro model for hemocyte-like activity, was used to investigate membrane properties, and assess the impact of larval transformation proteins (LTP) on identified ion channels...
March 20, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28319120/plos-neglected-tropical-diseases-2016-reviewer-and-editorial-board-thank-you
#16
EDITORIAL
(no author information available yet)
No abstract text is available yet for this article.
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28318148/barriers-to-innovation-in-human-rabies-prophylaxis-and-treatment-a-causal-analysis-of-insights-from-key-opinion-leaders-and-literature
#17
L H M van de Burgwal, A M G Neevel, C A C M Pittens, A D M E Osterhaus, C E Rupprecht, E Claassen
Rabies is an essentially 100% fatal, zoonotic disease, caused by Lyssaviruses. Currently, the disease is vaccine-preventable with pre- and post-exposure prophylaxis (PrEP and PEP). Still, rabies virus is estimated to cause up to 60,000 human deaths annually, of which the vast majority occurs in rural Asia and Africa, due to the inaccessibility of prophylaxis and non-existence of treatment. Despite these unmet clinical needs, rabies control mainly focuses on the sylvatic reservoir and drug innovation receives relatively little attention compared to other neglected tropical diseases (NTDs)...
March 20, 2017: Zoonoses and Public Health
https://www.readbyqxmd.com/read/28317545/phylogeny-and-pathogenicity-of-lasiodiplodia-species-associated-with-dieback-of-mango-in-peru
#18
Edgar Rodríguez-Gálvez, Pakita Guerrero, Carla Barradas, Pedro W Crous, Artur Alves
Mango, which is an important tropical fruit crop in the region of Piura (Peru), is known to be prone to a range of diseases caused by Lasiodiplodia spp. The aim of this study was to evaluate the incidence and prevalence of mango dieback in the region of Piura, and to identify the species of Lasiodiplodia associated with the disease and evaluate their pathogenicity towards mango. Mango dieback was present in all orchards surveyed but incidence varied with location. Identification of fungal isolates was based on morphological and cultural characteristics as well as sequence data of the rDNA internal transcribed spacer region (ITS) and translation elongation factor 1-alpha gene (tef1-α)...
April 2017: Fungal Biology
https://www.readbyqxmd.com/read/28316596/the-efficacy-of-humanized-antibody-against-the-sporothrix-antigen-gp70-in-promoting-phagocytosis-and-reducing-disease-burden
#19
José R F de Almeida, Karla L Santiago, Gilberto H Kaihami, Andrea Q Maranhão, Marcelo de Macedo Brígido, Sandro R de Almeida
Sporotrichosis is a subcutaneous mycosis distributed worldwide and is frequently reported in countries with tropical climates, as Latin America countries. We previously demonstrated that mice with sporotrichosis produce specific antibodies against a 70-kDa fungal protein, indicating that specific antibodies against this molecule may help to control the sporotrichosis. IgG1 monoclonal antibody was generated, and called mAbP6E7, in mice against a 70-kDa glycoprotein (gp70) of S. schenckii. The mAbP6E7 showed prophylactic and therapeutic activity against sporotrichosis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28316411/particle-induced-x-ray-emission-study-of-blood-samples-of-indian-kala-azar-patients
#20
Sangita Lahiry, Supriya Khanra, Rajiv Kumar, Anindita Chakraborty, Shyam Sundar, Mathummal Sudarshan, Madhumita Manna
Visceral leishmaniasis (VL) or Kala-azar (KA) is a neglected tropical disease caused by protozoan parasite, Leishmania sp. and is fatal, if left untreated. In this study, we measured trace elements (K, Fe, Cu, Zn, Br, Cl, S, Ca, Mn, Cr, Ni, As, Se, Rb and Sr) in the blood of Indian VL patients (32) by particle-induced X-ray emission (PIXE) study. Blood was collected from 36 subjects including healthy controls from Rambagh Kala-azar Hospital, Muzaffarpur, Bihar, India. PIXE experiment was carried out at the Institute of Physics, Bhubaneswar, India and data were analyzed by GUPIXWIN software...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
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