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https://www.readbyqxmd.com/read/28522204/peg-interferon-plus-nucleotide-analogue-treatment-versus-no-treatment-in-patients-with-chronic-hepatitis-b-with-a-low-viral-load-a-randomised-controlled-open-label-trial
#1
Annikki de Niet, Louis Jansen, Femke Stelma, Sophie B Willemse, Sjoerd D Kuiken, Sebastiaan Weijer, Carin M J van Nieuwkerk, Hans L Zaaijer, Richard Molenkamp, R Bart Takkenberg, Maarten Koot, Joanne Verheij, Ulrich Beuers, Hendrik W Reesink
BACKGROUND: Antiviral treatment is currently not recommended for patients with chronic hepatitis B with a low viral load. However, they might benefit from acquiring a functional cure (hepatitis B surface antigen [HBsAg] loss with or without formation of antibodies against hepatitis B surface antigen [anti-HBs]). We assessed HBsAg loss during peg-interferon-alfa-2a (peg-IFN) and nucleotide analogue combination therapy in patients with chronic hepatitis B with a low viral load. METHODS: In this randomised controlled, open-label trial, patients were enrolled from the Academic Medical Center (AMC), Amsterdam, Netherlands...
May 15, 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28521271/the-association-of-electroconvulsive-therapy-to-pharmacological-treatment-and-its-influence-on-cytokines
#2
Thiago Fernando Vasconcelos Freire, Neusa Sica da Rocha, Marcelo Pio de Almeida Fleck
INTRODUCTION: A growing body of evidence shows that disturbances in the immune system are involved in the pathogenesis of depression. Although the immune-modulating effects of antidepressants have been described, few studies have addressed the functioning of the immune system in relation to electroconvulsive therapy (ECT). This study aims to investigate if the addition of ECT to pharmacotherapy is associated with changes in cytokine levels. METHODS: Adult inpatients were invited to participate in this study on admission to a psychiatric unit...
May 9, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28509904/immunological-effects-of-behavioral-activation-with-exercise-in-major-depression-an-exploratory-randomized-controlled-trial
#3
F Euteneuer, K Dannehl, A Del Rey, H Engler, M Schedlowski, W Rief
Major depression (MD) is associated with peripheral inflammation and increased cardiovascular risk. Regular physical exercise can have anti-inflammatory effects. The present study examined whether behavioral activation with exercise affects inflammatory processes in MD. Ninety-eight patients with MD were randomly assigned to cognitive-behavioral therapy (CBT) emphasizing exercise during behavioral activation (CBT-E), CBT with pleasurable low-energy activities as an active control condition (CBT-C) or a passive waiting list control group (WL)...
May 16, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28507609/depression-and-alexithymia-on-weight-perception-in-patients-with-metabolic-syndrome-and-type-2-diabetes
#4
Maria Cristina de Oliveira Regina, Marcos Antonio Tambascia
BACKGROUND: Obesity's increasing follows decreased perception of weight status in obese persons, mainly female, undergoing age-related changes. OBJECTIVE: To study weight perception and psychological alterations associated to MS and T2DM. METHODS: 200 patients selected from Metabolic Syndrome Outpatient Clinic of University of Campinas. Instruments: Beck Depression and Beck Anxiety Inventories', Toronto Alexithymia Scale-26s, questionnaire and data from reports...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28503523/treadmill-exercise-ameliorates-depressive-symptoms-through-increasing-serotonin-expression-in-postpartum-depression-rats
#5
Eun-Sang Ji, Jae-Min Lee, Tae-Woon Kim, You-Mi Kim, Yeon-Soo Kim, Kijeong Kim
Postpartum depression (PPD) is defined as the depressive symptoms that occur from the moment of delivery until 12 months after delivery. PPD symptoms are closely associated with reduced activity of the serotonergic system. Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the pathogenesis of depression. Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step of 5-HT biosynthesis in the serotonergic neurons. Exercise exerts anti-depressive effect on depression patients as well as on animal models of depression...
April 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28503402/physical-exercise-for-treatment-of-mood-disorders-a-critical-review
#6
C M Hearing, W C Chang, K L Szuhany, T Deckersbach, A A Nierenberg, L G Sylvia
PURPOSE OF THE REVIEW: The purpose of this review is to critically assess the evidence for exercise as an adjunct intervention for major depressive disorder and bipolar disorder, chronic conditions characterized by frequent comorbid conditions as well as interepisodic symptoms with poor quality of life and impaired functioning. Individuals with these mood disorders are at higher risk of cardiovascular disease and premature death in part because of increased rates of obesity, inactivity, and diabetes mellitus compared to the general population...
December 2016: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/28501680/dilated-virchow-robin-spaces-in-the-hippocampus-impact-behaviors-and-effects-of-anti-depressant-treatment-in-model-of-depressed-rats
#7
Yuefeng Li, Jinchuan Yan, Xiaolan Zhu, Yan Zhu, Shun Yao, Yuhao Xu, Shenghong Ju
The occurrences of dilated Virchow-Robin spaces (dVRSs) and inflammatory factors were closely related with development of depression and antidepressants. The present study indicated accumulation of inflammatory factors in dVRSs played a practical role in behaviors and the treatment-resistant in rats with depression. Eighty-one male Wistar rats were exposed to chronic unpredictable mild stress (CUMS) until the model was successfully established. According to the detection of dVRSs on 7 T structural magnetic resonance imaging (MRI), rats were divided into two groups (45 CUMS(non-dVRSs) rats and 36 CUMS(dVRSs) rats)...
April 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28501397/effect-of-conjugated-linoleic-acid-and-acetate-on-milk-fat-synthesis-and-adipose-lipogenesis-in-lactating-dairy-cows
#8
N Urrutia, K J Harvatine
During biohydrogenation-induced milk fat depression (MFD), nutrients are spared from milk fat synthesis and are available for other metabolic uses. Acetate is the major carbon source spared and it may increase lipid synthesis in adipose tissue during MFD. The objective of this study was to compare the effect of trans-10, cis-12 conjugated linoleic acid (CLA) and the amount of acetate spared during CLA-induced MFD on adipose tissue lipogenesis. Nine multiparous, lactating, ruminally cannulated Holstein cows (244 ± 107 d in milk; 25 ± 8...
May 10, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28499317/-self-stigma-of-depression-scale-ssds-evaluation-of-the-german-version
#9
Anna Christin Makowski, Eva E Mnich, Olaf von dem Knesebeck
Objectives A better understanding of self-stigma facilitates the development and evaluation of anti-stigma measures. In this study, the Self-Stigma of Depression Scale (SSDS) is applied for the first time in Germany. The focus lies on feasibility and psychometric characteristics of the scale. Methods Data stem from a representative population survey in Germany (N = 2,013). The 16 items of the original SSDS are used to assess anticipated self-stigma in case of depression. Main component analysis is applied to analyze the factor structure...
May 12, 2017: Psychiatrische Praxis
https://www.readbyqxmd.com/read/28499312/evidence-for-the-involvement-of-monoaminergic-pathways-in-the-antidepressant-like-activity-of-cymbopogon-citratus-in-mice
#10
Solomon Umukoro, Somtochukwu I Ogboh, Osarume Omorogbe, Abdul-Lateef A Adekeye, Matthew O Olatunde
Objectives Depression is a complex neuropsychiatric disorder, which affects the quality of life of the sufferers and treatment approach is associated with serious adverse effects and sometimes therapeutic failures. Cymbopogon citratus leaf (CC) has been reported to exert anti-depressant effect but its mechanism of action is yet to be elucidated hence, the need for this study. Methods The anti-depressant-like effect of Cymbopogon citratus aqueous leaf was evaluated using forced swim test (FST), tail suspension test (TST) and yohimbine-induced lethality test (YLT) in aggregated mice...
May 12, 2017: Drug Research
https://www.readbyqxmd.com/read/28495316/effect-of-infectious-bursal-disease-ibd-vaccine-on-salmonella-enteritidis-infected-chickens
#11
Nagah Arafat, Abdelfattah H Eladl, Hebatallah Mahgoub, Reham A El-Shafei
BACKGROUND: Chickens infected with both infectious bursal disease virus (IBDV) and Salmonella had higher mortality. In this work, we investigated the effect of IBDV vaccine (modified live-virus bursal disease vaccine, Nobilis strain 228E®) on experimentally infected chickens with Salmonella Enteritidis (SE). METHODS: Four experimental groups were included in this study, negative control group, 228E®group, 228E®+SE infected group, and SE infected group. Chickens were ocularly administrated 228E® at 12days of age and orally infected with S...
May 8, 2017: Vaccine
https://www.readbyqxmd.com/read/28490237/phytochemistry-and-pharmacological-activities-of-the-genus-swertia-gentianaceae-a-review
#12
Jie Li, Yan-Li Zhao, Heng-Yu Huang, Yuan-Zhong Wang
Swertia plants have been considered to be medicinal plants useful for the treatment of various ailments for thousands of years, especially in Asian countries. This is due to the broad variety of chemical compounds that provide multiple ligands for bonding to different endogenous biomacromolecules for patients. Chemical constituents and pharmacological activities of Swertia plants are summarized in this paper. Approximately 419 metabolites and 40 bioactive compounds have been reported from 30 Swertia species, including xanthones, flavonoids, seco-iridiods, iridiods, triterpenoids, alkaloids, volatiles, and other secondary metabolites...
May 11, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28489058/the-neuroprotective-effects-of-phenolic-acids-molecular-mechanism-of-action
#13
Dominik Szwajgier, Kamila Borowiec, Katarzyna Pustelniak
The neuroprotective role of phenolic acids from food has previously been reported by many authors. In this review, the role of phenolic acids in ameliorating depression, ischemia/reperfusion injury, neuroinflammation, apoptosis, glutamate-induced toxicity, epilepsy, imbalance after traumatic brain injury, hyperinsulinemia-induced memory impairment, hearing and vision disturbances, Parkinson's disease, Huntington's disease, anti-amyotrophic lateral sclerosis, Chagas disease and other less distributed diseases is discussed...
May 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28488578/triterpenoids-from-aglaia-abbreviata-exert-cytotoxicity-and-multidrug-resistant-reversal-effect-in-mcf-7-adm-cells-via-reactive-oxygen-species-induction-and-p-glycoprotein-inhibition
#14
Juan Cen, Beibei Zheng, Rubing Bai, Li Zhang, Feng Zhang, Xia Zhang
Triterpenoids from the Aglaia have been shown cytotoxicity on a broad spectrum of human tumor cells. In the present study, we extracted triterpenoids AA-5 (1) and AA-6 (2) from stems of Aglaia abbreviata, and studied their cytotoxicity in multidrug resistant (MDR) MCF-7/ADM cells. After 48 h treatment, AA-5 (1) and AA-6 (2) significantly increased mitochondrial-mediated apoptosis by enhancing reactive oxygen species (ROS) with depressed mitochondrial membrane potential and caspase-9 activities. The drug efflux transporter P-glycoprotein (P-gp) and the intracellular antioxidant systems, involving Glutathione S-Transferase π, Glutathione and heme oxygenase-1, were also inhibited via the ROS-depressed Akt/NF-E2-related factor 2 pathway...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28488048/protective-angiotensin-type-2-receptors-in-the-brain-and-hypertension
#15
REVIEW
Annette D de Kloet, Ulrike M Steckelings, Colin Sumners
PURPOSE OF REVIEW: The goal of this review is to assess the evidence that activation of angiotensin type 2 receptors (AT2R) in the brain can lower blood pressure and possibly constitute an endogenous anti-hypertensive mechanism. RECENT FINDINGS: Recent studies that detail the location of AT2R in the brain, particularly within or near cardiovascular control centers, mesh well with findings from pharmacological and gene transfer studies which demonstrate that activation of central AT2R can influence cardiovascular regulation...
June 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28482013/hydrogen-sulfide-inhibits-chronic-unpredictable-mild-stress-induced-depressive-like-behavior-by-upregulation-of-sirt-1-involvement-in-suppression-of-hippocampal-endoplasmic-reticulum-stress
#16
Shu-Yun Liu, Dan Li, Hai-Ying Zeng, Li-Yuan Kan, Wei Zou, Ping Zhang, Hong-Feng Gu, Xiao-Qing Tang
Background: Hydrogen sulfide (H2S) is a crucial signaling molecule with a wide range of physiological functions. Previously, we have confirmed that stress-induced depression is accompanied with disturbance of H2S generation in hippocampus. The present work attempted to investigate the inhibitory effect of H2S on chronic unpredictable mild stress (CUMS)-induced depressive-like behaviors and the underlying mechanism. Methods: We established the rat model of CUMS to simulate depression...
May 6, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28480587/melatonin-successfully-rescues-hippocampal-bioenergetics-and-improves-cognitive-function-following-drug-intoxication-by-promoting-nrf2-are-signaling-activity
#17
Li-You Chen, Ting-Yi Renn, Wen-Chieh Liao, Fu-Der Mai, Ying-Jui Ho, George Hsiao, Ai-Wei Lee, Hung-Ming Chang
Prolonged exposure to gamma-hydroxybutyric acid (GHB) would cause drug intoxication in which impaired cognitive function results from enhanced hippocampal oxidative stress may serve as a major symptom in this deficiency. Considering melatonin possesses significant anti-oxidative efficacy, present study aims to determine whether melatonin would successfully promote the Nrf2-ARE signaling, depress oxidative stress, and rescue hippocampal bioenergetics and cognitive function following drug intoxication injury...
May 8, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28479211/why-are-depressed-patients-inflamed-a-reflection-on-20-years-of-research-on-depression-glucocorticoid-resistance-and-inflammation
#18
REVIEW
Carmine M Pariante
Studies over the last 20 years have demonstrated that increased inflammation and hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis are two of the most consistent biological findings in major depression and are often associated: but the molecular and clinical mechanisms underlying these abnormalities are still unclear. These findings are particularly enigmatic, especially considering the accepted notion that high levels of cortisol have an anti-inflammatory action, and therefore the coexistence of inflammation and hypercortisolemia in the same diagnostic group appears counter-intuitive...
May 4, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28476947/prenatal-ethanol-exposure-persistently-alters-endocannabinoid-signaling-and-endocannabinoid-mediated-excitatory-synaptic-plasticity-in-ventral-tegmental-area-dopamine-neurons
#19
Kathryn Hausknecht, Ying-Ling Shen, Rui-Xiang Wang, Samir Haj-Dahmane, Roh-Yu Shen
Prenatal ethanol exposure (PE) leads to increased addiction risk which could be mediated by enhanced excitatory synaptic strength in ventral tegmental area (VTA) dopamine (DA) neurons. Previous studies have shown that PE enhances excitatory synaptic strength by facilitating an anti-Hebbian form of long-term potentiation (LTP). In this study, we investigated the effect of PE on endocannabinoid-mediated long-term depression (eCB-LTD) in VTA DA neurons. Rats were exposed to moderate (3 g/kg/day) or high (6 g/kg/day) level of ethanol during gestation...
May 5, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28474231/fluoxetine-reverses-behavior-changes-in-socially-isolated-rats-role-of-the-hippocampal-gsh-dependent-defense-system-and-proinflammatory-cytokines
#20
Ivana Perić, Andrijana Stanisavljević, Peter Gass, Dragana Filipović
Exposure of an organism to chronic social isolation (CSIS) has been shown to have an important role in depression. Fluoxetine (Flx) is a first-line treatment for depression; however, its downstream mechanisms of action beyond serotonergic signaling remain ill-defined. We investigated the effect of 3 weeks of Flx (15 mg/kg/day) treatment on behavioral changes and protein expression/activity of the GSH-dependent defense system, including reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione reductase (GLR), and glutathione S-transferase (GST), as well as catalase (CAT), in the hippocampus of rats exposed to 6 weeks of CSIS...
May 4, 2017: European Archives of Psychiatry and Clinical Neuroscience
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