keyword
MENU ▼
Read by QxMD icon Read
search

Anti anxiety

keyword
https://www.readbyqxmd.com/read/28810562/anti-depressant-like-effects-of-jieyu-chufan-capsules-in-a-mouse-model-of-unpredictable-chronic-mild-stress
#1
Hui Zhao, Bingyu Liang, Linjie Yu, Yun Xu
Jieyu chufan (JYCF) is a well-known Chinese traditional medicine used for depression; however, the molecular mechanism underlying its anti-depressant action has remained elusive. In the present study, the anti-depressant effects of JYCF and the potential mechanisms were investigated in a mouse model. Five groups of 12 C57BL/6 mice each were used in the study, including a normal control group (NC group), a model control group (MC group) and three groups, which received different doses of JYCF (1.25, 2.5 and 5 g/kg) orally for 21 days (JYCF groups)...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809071/physicians-communication-of-risks-from-non-steroidal-anti-inflammatory-drugs-and-attitude-towards-providing-adverse-drug-reaction-information-to-patients
#2
Pacharaporn Phueanpinit, Juraporn Pongwecharak, Sermsak Sumanont, Janet Krska, Narumol Jarernsiripornkul
RATIONALE, AIMS, AND OBJECTIVES: Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed for orthopaedic conditions, therefore this study aimed to explore orthopaedic physicians' perceptions of their role in NSAID-risk communication, their attitudes towards the necessity of informing patients about adverse drug reactions (ADR), and factors associated with these. METHODS: Self-administered questionnaires were mailed to all 206 orthopaedic physicians working at hospitals in Northeastern Thailand...
August 15, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28802219/development-and-validation-of-a-high-performance-liquid-chromatography-tandem-mass-spectrometry-method-to-quantify-ly-354-740-in-rat-and-marmoset-plasma
#3
Fleur Gaudette, Adjia Hamadjida, Dominique Bédard, Stephen G Nuara, Francis Beaudry, Philippe Huot
LY-354,740 (eglumegad) is a selective and potent agonist of the metabotropic glutamate group II receptors (mGluR2,3) that has already entered clinical trials as a potential anti-psychotic agent and therefore has well-documented pharmacokinetic (PK), safety and tolerability profiles in human. Whereas its development as an anti-psychotic agent has not been pursued, LY-354,740 may have potential in other neuroscience-related fields, notably anxiety and neuro-protection. The common marmoset is a small primate that has long been used in neuroscience...
July 15, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28800160/exercise-attenuates-alveolar-bone-loss-and-anxiety-like-behaviour-in-rats-with-periodontitis
#4
Eric F Andrade, Débora R Orlando, Júlia A S Gomes, Renata de C Foureaux, Rafael C Costa, Mary S Varaschin, Gustavo P Rogatto, Rodrigo F de Moura, Luciano J Pereira
AIM: To evaluate the effects of physical training on inflammatory and behavioral parameters of Wistar rats with periodontal disease (PD). MATERIALS AND METHODS: Twenty four animals were distributed in a 2x2 factorial design (with and without exercise, with and without PD). Trained animals swimmed one hour daily during eight weeks. PD was induced by ligature 14 days before the end of experiment and in the last week all animals were submitted to the Marble Burying Test...
August 11, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28800105/anti-anxiety-effect-of-syringaresnol-4-o-%C3%AE-d-apiofuranosyl-1%C3%A2-2-%C3%AE-d-glucopyranoside-from-albizzia-julibrissin-durazz-leguminosae
#5
Jie Liu, Yue-Wei Lv, Jin-Li Shi, Xiao-Jie Ma, Yi Chen, Zhi-Quan Zheng, Sheng-Nan Wang, Jian-You Guo
Albizzia julibrissin Durazz, a Chinese Medicine, is commonly used for its anti-anxiety effects. (-)-syringaresnol-4-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranoside (SAG) is the main ingredient of Albizzia julibrissin Durazz. The present study investigated the anxiolytic effect and potential mechanisms on the HPA axis and monoaminergic systems of SAG on acute restraint-stressed rats. The anxiolytic effect of SAG was examined through an open field test and an elevated plus maze test. The concentration of CRF, ACTH, and CORT in plasma was examined by an enzyme-linked immune sorbent assay (ELISA) kit while neurotransmitters in the cerebral cortex and hippocampus of the brain were examined by High Performance Liquid Chromatography (HPLC)...
August 11, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28799972/increased-pain-sensitivity-in-accident-related-chronic-pain-patients-with-comorbid-posttraumatic-stress
#6
Henrik Bjarke Vaegter, Tonny Elmose Andersen, Mathea Harvold, Per Grunwald Andersen, Thomas Graven-Nielsen
OBJECTIVES: Posttraumatic stress disorder (PTSD) is prevalent in chronic pain, and associated with increased pain, hyperalgesia and psychological distress. This study aimed to investigate anti-nociceptive and pro-nociceptive pain mechanisms, pain intensity, and psychological distress (depression, anxiety, pain catastrophizing, and fear of movement) in patients with accident-related chronic spinal pain with (N=44) and without (N=64) comorbid PTSD characteristics. METHODS: Cuff algometry was performed on lower legs to assess pressure pain threshold (cPPT), tolerance (cPTT), temporal summation of pain (TSP: increase in pain scores to ten repeated stimulations), and conditioning pain modulation (CPM: increase in cPPT during cuff pain conditioning on the contralateral leg)...
August 9, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28797691/antidepressant-like-activity-of-venlafaxine-and-clonidine-in-mice-exposed-to-single-prolonged-stress-a-model-of-post-traumatic-stress-disorder-pharmacodynamic-and-molecular-docking-studies
#7
Natalia Malikowska, Łukasz Fijałkowski, Alicja Nowaczyk, Piotr Popik, Kinga Sałat
BACKGROUND: Post-traumatic stress disorder (PTSD) is a growing issue worldwide characterized by stress and anxiety in response to re-experiencing traumatic events which strongly impair patient's quality of life and social functions. Available antidepressant and anxiolytic drugs are not efficacious in the majority of treated individuals. This necessitates a significant medical demand to develop novel therapeutic strategies for PTSD. EXPERIMENTAL APPROACH: Animal model of PTSD was induced using a mouse single prolonged stress protocol (mSPS)...
August 7, 2017: Brain Research
https://www.readbyqxmd.com/read/28794421/beta-hydroxybutyrate-an-endogenic-nlrp3-inflammasome-inhibitor-attenuates-stress-induced-behavioral-and-inflammatory-responses
#8
Takehiko Yamanashi, Masaaki Iwata, Naho Kamiya, Kyohei Tsunetomi, Naofumi Kajitani, Nodoka Wada, Takahiro Iitsuka, Takahira Yamauchi, Akihiko Miura, Shenghong Pu, Yukihiko Shirayama, Ken Watanabe, Ronald S Duman, Koichi Kaneko
Neuro-inflammation has been shown to play a critical role in the development of depression. Beta-hydroxybutyrate (BHB) is a ketone body and has recently been reported to exert anti-inflammatory effects via inhibition of NLRP3 inflammasome. Here, we investigated the potential antidepressant and anti-inflammatory effects of BHB on rats exposed to acute and chronic stress. We examined the influence of repeated BHB administration on depressive and anxiety behaviors in a rodent model of chronic unpredictable stress (CUS)...
August 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28792097/a-closer-lens-cancer-survivors-supportive-intervention-preferences-and-interventions-received
#9
Joanna J Arch, Rachel Vanderkruik, Alex Kirk, Alaina L Carr
BACKGROUND: Cancer survivor preferences for formal interventions designed to provide psychological support remain relatively unknown. To address this gap, we evaluated cancer survivors' preferences for psychological intervention, whom they preferred to recommend such intervention, and how their preferences compared with what they currently received. METHODS: U.S. cancer survivors (n = 345) who were at least 2 months post-treatment for diverse forms of cancer were recruited online to complete a survey study...
August 9, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28789949/reduced-hippocampal-il-10-expression-altered-monoaminergic-activity-and-anxiety-and-depressive-like-behavior-in-female-mice-subjected-to-chronic-social-instability-stress
#10
Ainitze Labaka, Eneritz Gómez-Lázaro, Oscar Vegas, Joana Pérez-Tejada, Amaia Arregi, Larraitz Garmendia
Evidence indicates that release of pro-inflammatory cytokines induced by social stress contributes to affective disorders. Additionally, there are known sex differences in both the stress response and the stressors that can elicit this response. In this regard, the chronic social instability (CSI) rodent model of stress appears to be the best fit for the social nature of females. This study analyzed the effects of CSI on female mouse behavior, hippocampal cytokine expression, tryptophan metabolism and monoaminergic activity...
August 5, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28783932/evaluation-of-oxidant-antioxidant-status-and-cytokine-levels-in-patients-with-cannabis-use-disorder
#11
Huseyin Bayazit, Salih Selek, Ibrahim Fatih Karababa, Erdinc Cicek, Nurten Aksoy
Objective: Cannabis is the most commonly used illegal drug in the world and it has several adverse effects such as anxiety, panic reactions and psychotic symptoms. In this study, we aimed to evaluate oxidant, anti-oxidant status and cytokine levels in individuals with cannabis use disorder. Methods: Thirty-four patients with cannabis use disorder and 34 healthy controls were enrolled to the study. Serum total antioxidant status, total oxidant status and cytokine levels were investigated in patients with cannabis use disorder and healthy controls...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28780128/challenging-mental-health-related-stigma-in-china-systematic-review-and-meta-analysis-ii-interventions-among-people-with-mental-illness
#12
REVIEW
Ziyan Xu, Fangfang Huang, Markus Kösters, Nicolas Rüsch
People with mental illness often face different types of mental illness stigma that may affect their lives, including perceived stigma, self-stigma, harmful coping strategies and poor quality of life. Although anti-stigma interventions for people with mental illness from Western countries have been identified by recent systematic reviews, their efficacy in China is unknown. This review evaluates the efficacy of anti-stigma interventions among people with mental illness in Mainland China, Hong Kong, Taiwan and Macau...
September 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28777368/-melatonin-known-problems-and-perspectives-of-clinical-usage
#13
A V Zakharov, E V Khivintseva, V F Pytin, M S Sergeeva, O I Antipov
The article discusses well-known and ongoing studies of mechanisms of action of melatonin. The main clinical effects of melatonin are discussed. The emphasis on the chronobiological effect of melatonin, its adaptogenic and anti-carcinogenic properties has been done in the article. The most frequent manifestations of epiphyseal melatonin deficiency are various functional disorders in the form of insomnia, anxiety or depressive disorders. Recommendations on the effective use of melatonin in its deficiency due to pathology are given...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28777367/-antioxidant-anti-inflammatory-and-sedative-effects-of-melatonin-results-of-clinical-trials
#14
REVIEW
D I Burchakov, Yu B Uspenskaya
A literature review of clinical trials and systematic reviews on the antioxidant and anti-inflammatory effects of melatonin is presented. The results of animal studies and recent publications on the effects of melatonin in humans are summarized. Melatonin protects the cardiovascular system from destructive effects of ischemia/reperfusion, when the drug has been timely administered, has a neuroprotective effect in newborns with asphyxia. It is an effective drug in complex treatment of irritable bowel syndrome and inflammatory bowel diseases (Crohn's disease and ulcerative colitis)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28776350/comparison-of-baseline-characteristics-between-community-based-and-hospital-based-suicidal-ideators-and-its-implications-for-tailoring-strategies-for-suicide-prevention-korean-cohort-for-the-model-predicting-a-suicide-and-suicide-related-behavior
#15
C Hyung Keun Park, Jae Won Lee, Sang Yeol Lee, Jungjoon Moon, Se Hoon Shim, Jong Woo Paik, Shin Gyeom Kim, Seong Jin Cho, Min Hyuk Kim, Seokho Kim, Jae Hyun Park, Sungeun You, Hong Jin Jeon, Yong Min Ahn
In this cross-sectional study, we aimed to identify distinguishing factors between populations with suicidal ideation recruited from hospitals and communities to make an efficient allocation of limited anti-suicidal resources according to group differences. We analyzed the baseline data from 120 individuals in a community-based cohort (CC) and 137 individuals in a hospital-based cohort (HC) with suicidal ideation obtained from the Korean Cohort for the Model Predicting a Suicide and Suicide-related Behavior (K-COMPASS) study...
September 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28771498/autonomy-connectedness-mediates-sex-differences-in-symptoms-of-psychopathology
#16
Marrie H J Bekker, Marcel A L M van Assen
OBJECTIVES: This study aimed to examine if autonomy-connectedness, capacity for self-governance under the condition of connectedness, would mediate sex differences in symptoms of various mental disorders (depression, anxiety, eating disorders, antisocial personality disorder). METHOD: Participants (N = 5,525) from a representative community sample in the Netherlands filled out questionnaires regarding the variables under study. RESULTS: Autonomy-connectedness (self-awareness, SA; sensitivity to others, SO; capacity for managing new situations, CMNS) fully mediated the sex differences in depression and anxiety, and partly in eating disorder -(drive for thinness, bulimia, and body dissatisfaction) and anti-social personality disorder characteristics...
2017: PloS One
https://www.readbyqxmd.com/read/28764678/the-specific-and-combined-role-of-domestic-violence-and-mental-health-disorders-during-pregnancy-on-new-born-health
#17
Alexandre Archanjo Ferraro, Luis Augusto Rohde, Guilherme Vanoni Polanczyk, Adriana Argeu, Euripides Constantino Miguel, Sandra Josefina Ferraz Ellero Grisi, Bacy Fleitlich-Bilyk
BACKGROUND: Addressing impaired foetal growth is recognized as a public health priority. Certain risk factors for this condition, such as poor nutritional status at birth, have been found to be highly correlated with poverty. However, the role of psychosocial factors, specifically the mother's mental health and exposure to violence during pregnancy, have yet to be further explored. Our objective was to determine if there is a measurable association between combined psychosocial factors, specifically domestic violence and mental disorders, and birth outcomes, specifically birth nutritional status and preterm delivery...
August 1, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28758144/immune-signaling-mechanisms-of-ptsd-risk-and-symptom-development-insights-from-animal-models
#18
Jessica Deslauriers, Susan Powell, Victoria B Risbrough
Post-traumatic stress disorder (PTSD) is characterized by persistent re-experiencing of a traumatic event, avoidance, and increased arousal. The approved pharmacological treatments for PTSD have limited efficacy (~60% treatment response), supporting the need for identification of biomarkers and novel pharmacological therapies. Mounting evidence suggests increased inflammatory markers and altered immune gene expression correlate with the severity of symptoms in PTSD patients. However a causal role of immune signaling in development and maintenance of PTSD symptoms is not clear, as inflammation may also be an epiphenomenon related to metabolic and behavioral effects of stress...
April 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/28750834/protective-effect-of-atorvastatin-on-d-galactose-induced-aging-model-in-mice
#19
Elham Kaviani, Mohammadreza Rahmani, Ayat Kaeidi, Ali Shamsizadeh, Mohamad Allahtavakoli, Nazanin Mozafari, Iman Fatemi
Atorvastatin (Ator), competitive inhibitors of 3-hydroxymethyl-3-glutaryl-coenzyme-A reductase, is a cholesterol lowering drug. Ator has been shown to have neuroprotective, antioxidant and anti-inflammatory properties making that a potential candidate for the treatment of central nervous system (CNS) disorders. Here we assessed the effect of Ator on the d-galactose (d-gal)-induced aging in mice. For this purpose, Ator (0.1 and 1mg/kg/p.o.), was administrated daily in d-gal-received (500mg/kg/p.o.) mice model of aging for six weeks...
July 24, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28748167/therapeutic-efficacy-of-rose-oil-a-comprehensive-review-of-clinical-evidence
#20
REVIEW
Safieh Mohebitabar, Mahboobeh Shirazi, Sodabeh Bioos, Roja Rahimi, Farhad Malekshahi, Fatemeh Nejatbakhsh
OBJECTIVE: Rose oil is obtained from the petals of difference Rosa species especially Rosa centifolia L. and Rosa damascena Mill. Various pharmacological properties have been attributed to rose oil. The aim of the present study was to review the rose oil therapeutic effects which had been clinically evaluated in trial studies. MATERIALS AND METHODS: Google scholar, PubMed, Cochrane Library, and Scopus were searched for human studies which have evaluated the therapeutic effects of rose oil and published in English language until August 2015...
May 2017: Avicenna Journal of Phytomedicine
keyword
keyword
26420
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"