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https://www.readbyqxmd.com/read/29666578/individual-experiences-in-four-cancer-patients-following-psilocybin-assisted-psychotherapy
#1
Tara C Malone, Sarah E Mennenga, Jeffrey Guss, Samantha K Podrebarac, Lindsey T Owens, Anthony P Bossis, Alexander B Belser, Gabrielle Agin-Liebes, Michael P Bogenschutz, Stephen Ross
A growing body of evidence shows that existential and spiritual well-being in cancer patients is associated with better medical outcomes, improved quality of life, and serves as a buffer against depression, hopelessness, and desire for hastened death. Historical and recent research suggests a role for psilocybin-assisted psychotherapy in treating cancer-related anxiety and depression. A double-blind controlled trial was performed, where 29 patients with cancer-related anxiety and depression were randomly assigned to treatment with single-dose psilocybin (0...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29662734/effect-of-a-water-extract-of-curcuma-longa-on-emotional-states-in-healthy-participants
#2
Kengo Kawasaki, Koutarou Muroyama, Shinji Murosaki
Physiological symptoms of mood disturbances, such as fatigue or anxiety, are closely related to inflammation in the central nervous system or the whole body. Curcuma longa is widely used as a dietary spice and has been reported to have anti-inflammatory activity. To investigate the effect of a water extract of C. longa (WEC) on emotional states, a randomized, double-blind, placebo-controlled, parallel-group study was conducted with healthy participants. Forty-eight participants were randomly assigned to receive five tablets containing 150 mg WEC and 0...
2018: Bioscience of Microbiota, Food and Health
https://www.readbyqxmd.com/read/29662431/the-neuroprotective-effects-of-thymoquinone-a-review
#3
Tahereh Farkhondeh, Saeed Samarghandian, Ali Mohammad Pourbagher Shahri, Fariborz Samini
Thymoquinone (TQ), one of the main components active of Nigella sativa , exhibited very useful biomedical effects such as anti-inflammatory, antioxidant, antimicrobial, antiparasitic, anticancer, hypoglycemic, antihypertensive, and antiasthmatic effects. There are several studies about pharmacological activities of TQ but its neuroprotection effects are not fully described. The literature search has indicated many studies pertaining to the effects of TQ in neurological problems such as epilepsy, parkinsonism, anxiety, and improvement of learning and memory, and so on...
April 2018: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/29653128/serotonin-specific-lesions-of-the-dorsal-raphe-disrupt-maternal-aggression-and-caregiving-in-postpartum-rats
#4
M Allie Holschbach, Erika V Vitale, Joseph S Lonstein
The behavioral modifications associated with early motherhood, including high aggression, caring for young, and low anxiety are all affected by acute pharmacological manipulation of serotonin signaling. However, the effects on these behaviors of permanently disrupting serotonin signaling at one of its primary sources, the dorsal raphe (DR), have not been examined in detail. To address this, serotonin-specific lesions centered on the dorsomedial DR (DRdm; subregion most implicated in emotional behaviors) were induced at mid-pregnancy (day 15) or early postpartum (day 2) in rats using a saporin-conjugated neurotoxin targeting the serotonin transporter (Anti-SERT-SAP)...
April 10, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29642394/neuroprotective-effects-of-platonin-a-therapeutic-immunomodulating-medicine-on-traumatic-brain-injury-in-mice-after-controlled-cortical-impact
#5
Ting-Lin Yen, Chao-Chien Chang, Chi-Li Chung, Wen-Chin Ko, Chih-Hao Yang, Cheng-Ying Hsieh
Traumatic brain injury (TBI) is one of the leading causes of mortality worldwide and leads to persistent cognitive, sensory, motor dysfunction, and emotional disorders. TBI-caused primary injury results in structural damage to brain tissues. Following the primary injury, secondary injuries which are accompanied by neuroinflammation, microglial activation, and additional cell death subsequently occur. Platonin, a cyanine photosensitizing dye, has been used to treat trauma, ulcers, and some types of acute inflammation...
April 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29626565/antidepressant-like-actions-by-silencing-of-neuronal-elav-like-rna-binding-proteins-hub-and-huc-in-a-model-of-depression-in-male-mice
#6
Maria Domenica Sanna, Alessandro Quattrone, Nicoletta Galeotti
Currently available antidepressant drugs often fail to achieve full remission and patients might evolve to treatment resistance, showing the need to achieve a better therapy of depressive disorders. Increasing evidence supports that post-transcriptional regulation of gene expression is important in neuronal development and survival and a relevant role is played by RNA binding proteins (RBP). To explore new therapeutic strategies, we investigated the role of the neuron-specific ELAV-like RBP (HuB, HuC, HuD) in a mouse model of depression...
April 4, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29620640/acupuncture-for-anxiety-a-protocol-for-a-systematic-review-of-controlled-trials
#7
REVIEW
Sung-Youl Choi, Geun-Woo Kim
BACKGROUND: Acupuncture has been widely, used in Asian countries since the Yuan Dynasty in China. Moreover, acupuncture has been reported to exhibit anti-allergy effects in many clinical trials. This systematic review will assess the effectiveness, and safety of acupuncture for anxiety treatment. METHODS: Eleven databases, including Asian databases, will be searched for studies conducted through December in the year 2017. We will include randomized controlled trials (RCTs) assessing acupuncture for anxiety...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29615090/adolescent-mental-health-education-inscied-out-a-case-study-of-an-alternative-middle-school-population
#8
Joanna Yang, Roberto Lopez Cervera, Susannah J Tye, Stephen C Ekker, Chris Pierret
BACKGROUND: Mental illness contributes substantially to global disease burden, particularly when illness onset occurs during youth and help-seeking is delayed and/or limited. Yet, few mental health promotion interventions target youth, particularly those with or at high risk of developing mental illness ("at-risk" youth). Community-based translational research has the capacity to identify and intervene upon barriers to positive health outcomes. This is especially important for integrated care in at-risk youth populations...
April 3, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29611021/development-and-validation-of-a-brief-version-of-the-anti-bisexual-experiences-scale
#9
Christina Dyar, Brian A Feinstein, Joanne Davila
Experiencing anti-bisexual discrimination has been linked with numerous negative consequences, such as internalized stigma and symptoms of anxiety and depression. A commonly used measure of anti-bisexual discrimination in research is the Anti-Bisexual Experiences Scale (ABES). While this scale has been instrumental in advancing knowledge about discrimination against bisexual individuals, its length presents challenges to widespread use and it remains unknown if its psychometric properties are consistent across diverse genders and non-monosexual identities...
April 2, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29608897/uses-of-fluoxetine-in-nociceptive-pain-management-a-literature-overview
#10
REVIEW
Ahmed Barakat, Mostafa M Hamdy, Mohamed M Elbadr
Fluoxetine is one of the top ten prescribed antidepressants. Other therapeutic applications were approved for fluoxetine including, anxiety disorders, bulimia nervosa, and premature ejaculation. However, the role of fluoxetine in nociceptive pain management is still unclear. In this review, we discuss an overview of five possible roles of fluoxetine in pain management: intrinsic antinociceptive effect, enhancement of acute opioid analgesia, attenuation of tolerance development to opioid analgesia, attenuation of dependence development and abstinence syndrome, and attenuation of opioid induced hyperalgesia...
March 30, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29599709/caffeine-and-modafinil-ameliorate-the-neuroinflammation-and-anxious-behavior-in-rats-during-sleep-deprivation-by-inhibiting-the-microglia-activation
#11
Meetu Wadhwa, Garima Chauhan, Koustav Roy, Surajit Sahu, Satyanarayan Deep, Vishal Jain, Krishna Kishore, Koushik Ray, Lalan Thakur, Usha Panjwani
Background : Sleep deprivation (SD) plagues modern society due to the professional demands. It prevails in patients with mood and neuroinflammatory disorders. Although growing evidence suggests the improvement in the cognitive performance by psychostimulants during sleep-deprived conditions, the impending involved mechanism is rarely studied. Thus, we hypothesized that mood and inflammatory changes might be due to the glial cells activation induced modulation of the inflammatory cytokines during SD, which could be improved by administering psychostimulants...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29596867/the-short-term-stress-response-mother-nature-s-mechanism-for-enhancing-protection-and-performance-under-conditions-of-threat-challenge-and-opportunity
#12
REVIEW
Firdaus S Dhabhar
Our group has proposed that in contrast to chronic stress that can have harmful effects, the short-term (fight-or-flight) stress response (lasting for minutes to hours) is nature's fundamental survival mechanism that enhances protection and performance under conditions involving threat/challenge/opportunity. Short-term stress enhances innate/primary, adaptive/secondary, vaccine-induced, and anti-tumor immune responses, and post-surgical recovery. Mechanisms and mediators include stress hormones, dendritic cell, neutrophil, macrophage, and lymphocyte trafficking/function and local/systemic chemokine and cytokine production...
March 26, 2018: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/29588601/midazolam-activates-caspase-mapks-and-endoplasmic-reticulum-stress-pathways-and-inhibits-cell-cycle-and-akt-pathway-to-induce-apoptosis-in-tm3-mouse-leydig-progenitor-cells
#13
Fu-Chi Kang, Shu-Chun Wang, Ming-Min Chang, Bo-Syong Pan, Kar-Lok Wong, Ka-Shun Cheng, Edmund Cheung So, Bu-Miin Huang
Background: Midazolam (MDZ) has powerful hypnosis, amnesia, anti-anxiety and anticonvulsant effects. Studies have shown that prenatally developmental toxicity of diazepam can be observed in many organs/tissues. However, it remains elusive in male reproductive system. Materials and methods: TM3 mouse Leydig progenitor cell line was used to determine whether MDZ has any unfavorable effects. Results: Midazolam significantly decreased cell viability in dose- and time-dependent manners in TM3 cells...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29581730/the-impact-of-rhodiola-rosea-on-the-gut-microbial-community-of-drosophila-melanogaster
#14
Khachik E Labachyan, Dara Kiani, Evgueni A Sevrioukov, Samuel E Schriner, Mahtab Jafari
Background: The root extract of Rhodiola rosea has historically been used in Europe and Asia as an adaptogen, and similar to ginseng and Shisandra , shown to display numerous health benefits in humans, such as decreasing fatigue and anxiety while improving mood, memory, and stamina. A similar extract in the Rhodiola family, Rhodiola crenulata , has previously been shown to confer positive effects on the gut homeostasis of the fruit fly, Drosophila melanogaster. Although, R. rosea has been shown to extend lifespan of many organisms such as fruit flies, worms and yeast, its anti-aging mechanism remains uncertain...
2018: Gut Pathogens
https://www.readbyqxmd.com/read/29563960/compassion-fatigue-and-substance-use-among-nurses
#15
Reem Jarrad, Sawsan Hammad, Tagreed Shawashi, Naser Mahmoud
Aim: This study aimed to detect if there were differences in compassion fatigue (CF) among nurses based on substance use and demographic variables of gender, marital status, type of health institution and income. Background: Compassion fatigue is considered an outcome of poorly handled stressful situations in which nurses may respond with self-harming behaviours like substance use. Evidence in this area is critically lacking. Methods: This study used a descriptive design to survey differences in CF of 282 nurses...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29555902/predator-secreted-sulfolipids-induce-defensive-responses-in-c-elegans
#16
Zheng Liu, Maro J Kariya, Christopher D Chute, Amy K Pribadi, Sarah G Leinwand, Ada Tong, Kevin P Curran, Neelanjan Bose, Frank C Schroeder, Jagan Srinivasan, Sreekanth H Chalasani
Animals respond to predators by altering their behavior and physiological states, but the underlying signaling mechanisms are poorly understood. Using the interactions between Caenorhabditis elegans and its predator, Pristionchus pacificus, we show that neuronal perception by C. elegans of a predator-specific molecular signature induces instantaneous escape behavior and a prolonged reduction in oviposition. Chemical analysis revealed this predator-specific signature to consist of a class of sulfolipids, produced by a biochemical pathway required for developing predacious behavior and specifically induced by starvation...
March 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29549880/integration-of-homeopathy-and-complementary-medicine-in-the-tuscan-public-health-system-and-the-experience-of-the-homeopathic-clinic-of-the-lucca-hospital
#17
E Rossi, M Di Stefano, M Picchi, M A Panozzo, C Noberasco, L Nurra, S Baccetti
INTRODUCTION:  The healthcare programs of the Region of Tuscany (Italy) have started the process of integration of some types of complementary medicine (CM), including homeopathy, which began in 1996. The Homeopathic Clinic of Lucca was opened in 1998, followed by the Homeopathic Clinic for Women in 2003, and the Clinic for CM and Diet in Oncology in 2013. METHODS:  Observational longitudinal studies conducted on 5,877 patients (3,937 in the general clinic, 1,606 in the women's clinic and 334 in oncology) were consecutively examined from 2003 to 2016...
March 17, 2018: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/29549392/psychoactive-drug-exposure-during-breastfeeding-a-critical-need-for-preclinical-behavioral-testing
#18
REVIEW
Irving Zucker
Breastfeeding women are excluded from clinical trials of psychoactive drugs because of ethical concerns. Animal testing, which often is predictive of adverse effects in humans, represents the only avenue available for assessing drug safety for human offspring exposed to drugs during lactation. I determined whether behavioral outcomes for children exposed during breastfeeding to antidepressants, anxiolytics, antipsychotics, anti-seizure medications, analgesics, sedatives, and marijuana can be predicted by rodent studies of offspring exposed to drugs during lactation...
March 16, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29541930/assessment-of-the-anticonvulsant-potency-of-ursolic-acid-in-seizure-threshold-tests-in-mice
#19
Dorota Nieoczym, Katarzyna Socała, Piotr Wlaź
Ursolic acid (UA) is a plant derived compound which is also a component of the standard human diet. It possesses a wide range of pharmacological properties, i.e., antioxidant, anti-inflammatory, antimicrobial and antitumor, which have been used in folk medicine for centuries. Moreover, influence of UA on central nervous system-related processes, i.e., pain, anxiety and depression, was proved in experimental studies. UA also revealed anticonvulsant properties in animal models of epilepsy and seizures. The aim of the present study was to investigate the influence of UA on seizure thresholds in three acute seizure models in mice, i...
March 14, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29534023/internalized-transphobia-resilience-and-mental-health-applying-the-psychological-mediation-framework-to-italian-transgender-individuals
#20
Cristiano Scandurra, Vincenzo Bochicchio, Anna Lisa Amodeo, Concetta Esposito, Paolo Valerio, Nelson Mauro Maldonato, Dario Bacchini, Roberto Vitelli
Transgender and gender nonconforming (TGNC) people are a highly-stigmatized population. For this reason, they might internalize society's normative gender attitudes and develop negative mental health outcomes. As an extension of the minority stress model, the psychological mediation framework sheds light on psychological processes through which anti-transgender discrimination might affect mental health. Within this framework, the current study aimed at assessing in 149 TGNC Italian individuals the role of internalized transphobia as a mediator between anti-transgender discrimination and mental health, considering resilience as the individual-level coping mechanism buffering this relationship...
March 13, 2018: International Journal of Environmental Research and Public Health
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