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https://www.readbyqxmd.com/read/28431057/quantitative-analysis-of-pkp2-and-neighbouring-genes-in-a-patient-with-arrhythmogenic-right-ventricular-cardiomyopathy-caused-by-heterozygous-pkp2-deletion
#1
Keiko Sonoda, Seiko Ohno, Sou Otuki, Koichi Kato, Nobue Yagihara, Hiroshi Watanabe, Takeru Makiyama, Tohru Minamino, Minoru Horie
Aims: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a disease mainly caused by desmosome gene mutations. The genetic culprit, however, remains elusive in ∼50% of ARVC patients. One of the reasons for missing genetic abnormalities is the difficulty in detecting large deletions/duplications, which are called as copy number variation (CNV) by the Sanger sequencing method. This study aimed to identify CNVs in PKP2 and a part of other desmosome genes in ARVC patients. Methods and Results: The study cohort consisted of 71 ARVC probands who were diagnosed as definite or borderline cases based on 2010 Task Force Criteria...
April 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28428879/a-systems-biology-approach-to-investigating-the-influence-of-exercise-and-fitness-on-the-composition-of-leukocytes-in-peripheral-blood
#2
Michael P Gustafson, Ara Celi DiCostanzo, Courtney M Wheatley, Chul-Ho Kim, Svetlana Bornschlegl, Dennis A Gastineau, Bruce D Johnson, Allan B Dietz
BACKGROUND: Exercise immunology has become a growing field in the past 20 years, with an emphasis on understanding how different forms of exercise affect immune function. Mechanistic studies are beginning to shed light on how exercise may impair the development of cancer or be used to augment cancer treatment. The beneficial effects of exercise on the immune system may be exploited to improve patient responses to cancer immunotherapy. METHODS: We investigated the effects of acute exercise on the composition of peripheral blood leukocytes over time in a male population of varying fitness...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28421192/exercise-and-protein-intake-a-synergistic-approach-against-sarcopenia
#3
REVIEW
Anna Maria Martone, Emanuele Marzetti, Riccardo Calvani, Anna Picca, Matteo Tosato, Luca Santoro, Angela Di Giorgio, Antonio Nesci, Alex Sisto, Angelo Santoliquido, Francesco Landi
Sarcopenia, the age-dependent loss of muscle mass and function/strength, is increasingly recognized as a major risk factor for adverse outcomes in frail older people. As such, the skeletal muscle is a relevant target for interventions aimed at preventing or postponing the occurrence of negative health-related events in late life. The association among physical inactivity, insufficient intake of energy and protein, and poor muscle health in older adults suggests that physical exercise and targeted nutritional supplementation may offer substantial therapeutic gain against sarcopenia and its negative correlates...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28421126/femoral-neck-strain-during-maximal-contraction-of-isolated-hip-spanning-muscle-groups
#4
Saulo Martelli
The aim of the study was to investigate femoral neck strain during maximal isometric contraction of the hip-spanning muscles. The musculoskeletal and the femur finite-element models from an elderly white woman were taken from earlier studies. The hip-spanning muscles were grouped by function in six hip-spanning muscle groups. The peak hip and knee moments in the model were matched to corresponding published measurements of the hip and knee moments during maximal isometric exercises about the hip and the knee in elderly participants...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28419001/new-insights-into-the-impact-of-dehydration-on-blood-flow-and-metabolism-during-exercise
#5
Steven J Trangmar, José González-Alonso
Exercise-induced dehydration can lead to impaired perfusion to multiple regional tissues and organs. We propose that the impact of dehydration on regional blood flow and metabolism is dependent on the extent of the cardiovascular demand imposed by exercise, with the greatest physiological strain seen when approaching cardiovascular and aerobic capacities.
April 17, 2017: Exercise and Sport Sciences Reviews
https://www.readbyqxmd.com/read/28418696/eccentric-exercise-kinesiology-tape-and-balance-in-healthy-men
#6
Simona Hosp, Ramona Folie, Robert Csapo, Michael Hasler, Werner Nachbauer
CONTEXT:   Deficits in balance have been identified as a possible risk factor for knee injuries in athletes. Despite a lack of evidence for its effectiveness, kinesiology tape (KT) is widely used to prevent knee injuries. OBJECTIVE:   To investigate the influence of KT at the knee joint on balance ability in healthy men after eccentric exercise. DESIGN:   Crossover study. SETTING:   University laboratory. PATIENTS OR OTHER PARTICIPANTS:   Twelve young men with no history of lower limb injury volunteered for the study (age = 23...
April 18, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28417093/instability-resistance-training-for-health-and-performance
#7
REVIEW
Erika Zemková
Recently, resistance exercises performed on an unstable surface have become part of athletic training and rehabilitation. Accordingly, their role in performance and health-oriented strength training has increasingly emerged as a matter of interest to researchers and conditioning specialists. A more pronounced activation of stabilizing muscles is assumed to be the main feature of instability resistance exercises. This assumption has been proven by EMG studies, which have highlighted significantly greater electromyographic activity of trunk-stabilizing muscles during exercises under unstable as compared to stable conditions...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28415013/the-effect-of-exercise-on-fatigue-and-physical-functioning-in-breast-cancer-patients-during-and-after-treatment-and-at-6-months-follow-up-a-meta-analysis
#8
REVIEW
L K Juvet, I Thune, I K Ø Elvsaas, E A Fors, S Lundgren, G Bertheussen, G Leivseth, L M Oldervoll
Breast cancer is the leading cause of cancer in women worldwide. Exercise interventions may improve physical and psychological factors during and after active breast cancer treatment. The aim of this systematic review was to assess the current knowledge regarding the efficacy of physical exercise with respect to fatigue and self-reported physical functioning. Systematic searches in Cochrane Library, Medline, Embase, Cinahl, PsycINFO, AMED and PEDro. After assessing the quality of the studies, we identified 25 randomized controlled trials that included 3418 breast cancer patients...
April 14, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28413958/anti-fatigue-effects-of-active-ingredients-from-traditional-chinese-medicine-a-review
#9
Si-Si Zhou, Jian-Guo Jiang
Fatigue, a phenomenon which is believed to be caused by body exercise, can lead to the failure of predetermined exercise intensity maintenance and sport ability declination. The usage of traditional Chinese medicine (TCM) in the treatment of fatigue has long been practiced in clinical and showed significant effects. This article covers related literatures in recent years and sorts the effective ingredients from TCM for treating fatigue into a few categories including alkaloids, saponins, polysaccharides, polyphenols, polypeptide, terpene, proteins and other active ingredients...
April 14, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28412822/determinants-of-lifestyle-behavior-in-iranian-adults-with-prediabetes-applying-the-theory-of-planned-behavior
#10
Fatemeh Rahmati-Najarkolaei, Amir H Pakpour, Mohsen Saffari, Mahboobeh Sadat Hosseini, Fereshteh Hajizadeh, Hui Chen, Mir Saeed Yekaninejad
OBJECTIVE: Prediabetic condition can lead to development of type 2 diabetes, especially in individuals who do not adhere to a healthy lifestyle. The aim of the present study was to investigate the socio-cognitive factors using the Theory of Planned Behavior (TPB) that may be associated with the choice of lifestyle in prediabetic patients. METHODS: A prospective study with one-month follow up was designed to collect data from 350 individuals with prediabetic conditions...
April 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28410504/exercise-training-in-older-adults-what-effects-on-muscle-oxygenation-a-systematic-review
#11
REVIEW
Elie Fiogbé, Verena de Vassimon-Barroso, Anielle Cristhine de Medeiros Takahashi
AIM: To determine the effects of different modality of exercise training programs on muscle oxygenation in older adults. METHODS: Relevant articles were searched in PubMed, Web of Science, Science Direct and Scopus, using the keywords: "Aged" AND "Muscle oxygenation" AND (Exercise OR "Exercise therapy" OR "Exercise Movement Techniques" OR Hydrotherapy), without limitation concerning the publication date. To be included in the full analysis, the study had to be a randomized controlled trial in which older adults participants (mean age: 65 years at least) were submitted to an exercise-training program and muscle oxygenation assessment...
March 20, 2017: Archives of Gerontology and Geriatrics
https://www.readbyqxmd.com/read/28409512/immediate-effects-of-different-types-of-stretching-exercises-on-badminton-jump-smash
#12
Hwi S Jang, Daeho Kim, Jihong Park
BACKGOUND: Since different types of stretching exercises may alter athletic performance, we compared the effects of three types of stretching exercises on badminton jump smash. METHODS: Sixteen male collegiate badminton players performed one of three different stretching exercises in a counterbalanced order on different days. Static stretching had seven typical stretches, while dynamic stretching involved nine dynamic movements, and resistance dynamic stretching was performed with weighted vests and dumbbells...
April 13, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28409398/middle-cerebral-artery-blood-flow-velocity-during-a-4%C3%A2-km-cycling-time-trial
#13
Ben Rattray, Brittany A Smale, Joseph M Northey, Disa J Smee, Nathan G Versey
PURPOSE: This study sought to describe middle cerebral artery blood flow velocity (MCAv) during a 4 km cycling time trial, and relate it to different pacing strategies adopted by participants. METHODS: After familiarisation and a standardised exercise protocol, 15 male trained cyclists rode a 4 km time trial on a cycling ergometer. MCAv was assessed via transcranial Doppler ultrasound in the right hemisphere at resting baseline, and throughout the time trial. Mean arterial pressure, end-tidal partial pressure of carbon dioxide (PetCO2) and heart rate were assessed alongside MCAv...
April 13, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28408011/determining-criteria-and-weights-for-prioritizing-health-technologies-based-on-the-preferences-of-the-general-population-a-new-zealand-pilot-study
#14
Trudy Sullivan, Paul Hansen
OBJECTIVES: The use of multicriteria decision analysis for health technology prioritization depends on decision-making criteria and weights according to their relative importance. We report on a methodology for determining criteria and weights that was developed and piloted in New Zealand and enables extensive participation by members of the general population. METHODS: Stimulated by a preliminary ranking exercise that involved prioritizing 14 diverse technologies, six focus groups discussed what matters to people when thinking about technologies that should be funded...
April 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/28407637/pneumatic-compression-but-not-exercise-can-avoid-intradialytic-hypotension-a-randomized-trial
#15
Valeria R C Álvares, Camila D Ramos, Benedito J Pereira, Ana Lucia Pinto, Rosa M A Moysés, Bruno Gualano, Rosilene M Elias
BACKGROUND: Conventional hemodialysis (HD) is associated with dialysis-induced hypotension (DIH) and ineffective phosphate removal. As the main source of extracellular fluid removed during HD are the legs, we sought to reduce DIH and increase phosphate removal by using cycling and pneumatic compression, which would potentially provide higher venous return, preserving central blood flow and also offering more phosphate to the dialyzer. METHODS: We evaluated 21 patients in a randomized crossover fashion in which each patient underwent 3 different HD: control; cycling exercise during the first 60 min; and pneumatic compression during the first 60 min...
April 14, 2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28407476/measurement-of-sodium-concentration-in-sweat-samples-comparison-of-five-analytical-techniques
#16
Eric D B Goulet, Audrey Asselin, Jonathan Gosselin, Lindsay B Baker
PURPOSE: Sweat sodium concentration (SSC) can be determined using different analytical techniques (ATs), which may have implications for athletes and scientists. This study compared the SSC measured with five ATs: ion chromatography (IChr), flame photometry (FP), direct (DISE) and indirect (IISE) ion selective electrode and ion conductivity (IC). METHODS: Seventy sweat samples collected from 14 athletes were analyzed with 5 instruments: the 883 Basic IC Plus (IChr, reference instrument), AAnalyst 200 (FP), Cobas 6000 (IISE), Sweat-Chek (IC) and B-722 Laqua Twin (DISE)...
April 13, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28406936/enhancing-consolidation-of-a-rotational-visuomotor-adaptation-task-through-acute-exercise
#17
Blai Ferrer-Uris, Albert Busquets, Virginia Lopez-Alonso, Miguel Fernandez-Del-Olmo, Rosa Angulo-Barroso
We assessed the effect of a single bout of intense exercise on the adaptation and consolidation of a rotational visuomotor task, together with the effect of the order of exercise presentation relative to the learning task. Healthy adult participants (n = 29) were randomly allocated to one of three experimental groups: (1) exercise before task practice, (2) exercise after task practice, and (3) task practice only. After familiarization with the learning task, participants undertook a baseline practice set. Then, four 60° clockwise rotational sets were performed, comprising an adaptation set and three retention sets at 1 h, 24 h, and 7 days after the adaptation set...
2017: PloS One
https://www.readbyqxmd.com/read/28406553/detection-of-factor-xiii-deficiency-data-from-multicentre-exercises-amongst-uk-neqas-and-pro-rbdd-project-laboratories
#18
I Jennings, S Kitchen, M Menegatti, R Palla, I Walker, M Makris, F Peyvandi
INTRODUCTION: FXIII deficiency is a rare bleeding disorders, and specific FXIII assays are recommended to detect this deficiency. We investigated the performance and accuracy of FXIII investigations in two exercises, comparing centres enrolled in the PRO-RBDD project (prospective data collection on patients with fibrinogen and Factor XIII deficiencies), and UK NEQAS BC centres. METHODS: Samples from a FXIII deficient subject and a normal donor were sent to participating centres, to investigate for FXIII deficiency, and interpret their results...
April 13, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28401194/effect-of-electrical-stimulation-on-blood-flow-velocity-and-vessel-size
#19
Hee-Kyung Jin, Tae-Yeon Hwang, Sung-Hyoun Cho
Interferential current electrical stimulation alters blood flow velocity and vessel size. We aimed to investigate the changes in the autonomic nervous system depending on electrical stimulation parameters. Forty-five healthy adult male and female subjects were studied. Bipolar adhesive pad electrodes were used to stimulate the autonomic nervous system at the thoracic vertebrae 1-4 levels for 20 min. Using Doppler ultrasonography, blood flow was measured to determine velocity and vessel size before, immediately after, and 30 min after electrical stimulation...
January 2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/28400883/rehabilitation-after-rotator-cuff-repair
#20
REVIEW
Ourania Nikolaidou, Stefania Migkou, Christos Karampalis
BACKGROUND: Rotator cuff tears are a very common condition that is often incapacitating. Whether non-surgical or surgical, successful management of rotator cuff disease is dependent on appropriate rehabilitation. If conservative management is insufficient, surgical repair is often indicated. Postsurgical outcomes for patients having had rotator cuff repair can be quite good. A successful outcome is much dependent on surgical technique as it is on rehabilitation. Numerous rehabilitation protocols for the management of rotator cuff disease are based primarily on clinical experience and expert opinion...
2017: Open Orthopaedics Journal
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