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https://www.readbyqxmd.com/read/29028111/dna-methylation-of-methylation-complex-genes-in-relation-to-stress-and-genome-wide-methylation-in-mother-newborn-dyads
#1
Christopher J Clukay, David A Hughes, Nicole C Rodney, Darlene A Kertes, Connie J Mulligan
OBJECTIVES: Early life stress is known to have enduring biological effects, particularly with respect to health. Epigenetic modifications, such as DNA methylation, are a possible mechanism to mediate the biological effect of stress. We previously found correlations between maternal stress, newborn birthweight, and genome-wide measures of DNA methylation. Here we investigate ten genes related to the methylation/demethylation complex in order to better understand the impact of stress on health...
October 13, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29026554/aortic-stent-graft-placement-under-extracorporeal-membrane-oxygenation-in-severe-multiple-trauma
#2
Mathias Stroehle, Wolfgang Lederer, Stefan Schmid, Bernhard Glodny, Andreas P Chemelli, Franz J Wiedermann
Placement of an aortic stent graft under extracorporeal membrane oxygenation was the life-saving procedure in a case of severe head trauma and traumatic aortic dissection after injured by a railroad engine. Timely access to neurosurgery, heart surgery, and radiology providing minimal invasive interventions increase the chances of a favorable outcome.
October 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/29023379/effect-of-early-pelvic-binder-use-in-the-emergency-management-of-suspected-pelvic-trauma-a-retrospective-cohort-study
#3
Sheng-Der Hsu, Cheng-Jueng Chen, Yu-Ching Chou, Sheng-Hao Wang, De-Chuan Chan
BACKGROUND: We aimed to evaluate the effect of early pelvic binder use in the emergency management of suspected pelvic trauma, compared with the conventional stepwise approach. METHODS: We enrolled trauma patients with initial stabilization using a pelvic binder when suspecting pelvic injury. The inclusion criteria were traumatic injury requiring a trauma team and at least one of the following: a loss of consciousness or a Glasgow coma score (GCS) of <13; systolic blood pressure of <90 mmHg; falling from ≥6 m; injury to multiple vital organs; and suspected pelvic injury...
October 12, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29022789/the-impact-of-mechanism-on-the-management-and-outcome-of-penetrating-colonic-trauma
#4
G V Oosthuizen, V Y Kong, T Estherhuizen, J L Bruce, G L Laing, J J Odendaal, D L Clarke
Introduction In light of continuing controversy surrounding the management of penetrating colonic injuries, we set out to compare the outcome of penetrating colonic trauma according to whether the mechanism of injury was a stab wound or a gunshot wound. Methods Our trauma registry was interrogated for the 5-year period from January 2012 to December 2016. All patients over the age of 18 years with penetrating trauma (stab or gunshot) and with intraoperatively proven colonic injury were reviewed. Details of the colonic and concurrent abdominal injuries were recorded, together with the operative management strategy...
September 15, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29020716/improving-joint-pain-and-function-in-osteoarthritis
#5
Claire Owens, Philip G Conaghan
Osteoarthritis has become a major chronic pain condition. It affects more than 10% of adults and accounts for almost 10% of health service resources. The impact of osteoarthritis is amplified by underuse of effective muscle strengthening exercises and a focus on often less effective and poorly tolerated analgesic therapies. Although traditionally considered to be primarily a disease of cartilage, there is now ample evidence that typical clinical osteoarthritis involves multiple tissue pathologies. Increased BMI is associated with a higher incidence of knee osteoarthritis...
December 2016: Practitioner
https://www.readbyqxmd.com/read/29020127/an-exploration-of-addiction-in-adults-experiencing-early-life-stress-a-metasynthesis
#6
Carla Araujo Bastos Teixeira, Gerri Lasiuk, Sylvia Barton, Maria Neyrian de Fatima Fernandes, Edilaine Cristina da Silva Gherardi-Donato
OBJECTIVE: to review and synthesize qualitative research on the links between early-life stress and addiction behaviours in adulthood. METHOD: metasynthesis to review qualitative research findings based on procedures that outline how to identify themes or constructs across studies in a specific area. Comprehensive searches of multiple electronic databases were performed. The initial search yielded 1050 articles and the titles and abstracts were screened for inclusion based on predetermined criteria...
October 5, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29018389/measuring-depression-in-a-non-western-war-affected-displaced-population-measurement-equivalence-of-the-beck-depression-inventory
#7
Nuwan Jayawickreme, Jay Verkuilen, Eranda Jayawickreme, Kaylaliz Acosta, Edna B Foa
Depression is commonly seen in survivors of conflict and disaster across the world. There is a dearth of research on the validity of commonly used measures of depression in these populations. Measurements of depression that are used in multiple contexts need to meet measurement equivalence, i.e., the instrument measures the same construct in the same manner across different groups. The Beck Depression Inventory (BDI) was administered to female trauma survivors in the United States (n = 268) and female survivors of war in Sri Lanka (n = 149)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29018041/spontaneous-breathing-trials-and-conservative-sedation-practices-reduce-mechanical-ventilation-duration-in-subjects-with-ards
#8
Richard H Kallet, Hanjing Zhuo, Vivian Yip, Antonio Gomez, Michael S Lipnick
BACKGROUND: Spontaneous breathing trials (SBTs) and daily sedation interruptions (DSIs) reduce both the duration of mechanical ventilation and ICU length of stay (LOS). The impact of these practices in patients with ARDS has not previously been reported. We examined whether implementation of SBT/DSI protocols reduce duration of mechanical ventilation and ICU LOS in a retrospective group of subjects with ARDS at a large, urban, level-1 trauma center. METHODS: All ARDS survivors from 2002 to 2016 (N = 1,053) were partitioned into 2 groups: 397 in the pre-SBT/DSI group (June 2002-December 2007) and 656 in the post-SBT/DSI group (January 2009-April 2016)...
October 10, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29017731/impact-of-geriatric-consultations-on-clinical-outcomes-of-elderly-trauma-patients-a-retrospective-analysis
#9
James P Dugan, Keith M Burns, Mustafa Baldawi, David G Heidt
INTRODUCTION: The elderly account for a large proportion of morbidity and mortality secondary to trauma, despite lower-energy mechanisms of injury and fewer trauma admissions. The benefit of geriatric trauma consultation services (GTCS) to this population remains unclear. METHODS: We performed a retrospective cohort analysis of a GTCS, which was established in January 2015. Patients over 60 admitted to the trauma service from January of 2014 to February 2016 were eligible...
September 19, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28994362/perceived-workplace-interpersonal-support-among-workers-of-the-fukushima-daiichi-nuclear-power-plants-following-the-2011-accident-the-fukushima-nuclear-energy-workers-support-news-project-study
#10
Sho Takahashi, Jun Shigemura, Yoshitomo Takahashi, Soichiro Nomura, Aihide Yoshino, Takeshi Tanigawa
OBJECTIVE: The 2011 Fukushima Daiichi nuclear accident was the worst nuclear disaster since Chernobyl. The Daiichi workers faced multiple stressors (workplace trauma, victim experiences, and public criticism deriving from their company's post-disaster management). Literatures suggest the importance of workplace interpersonal support (WIS) in enhancing psychological health among disaster workers. We sought to elucidate the role of their demographics, disaster-related experiences, and post-traumatic stress symptoms on perceived WIS...
October 10, 2017: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/28990979/mortality-after-high-energy-pelvic-fractures-in-patients-of-age-65-or-older
#11
Dayley S Keil, Steven Gross, Rachel B Seymour, Stephen Sims, Madhav A Karunakar
OBJECTIVES: To document in-hospital and 1-year mortality rates following high-energy pelvic fracture in patients age 65 or older as compared to a younger cohort. DESIGN: Retrospective review. SETTING: Urban level 1 academic trauma center. PATIENTS: Seventy consecutive patients age ≥ 65 years treated for pelvic fracture resulting from high-energy mechanism from 2008 to 2011. One hundred forty patients age 18-64 were matched to the study population based on mechanism of injury and OTA Code 61 subtype for comparison...
September 29, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28989885/impact-of-severity-of-illness-on-the-function-of-the-hypothalamo-pituitary-gonadal-axis-in-postmenopausal-women-with-acute-severe-illness-implications-for-predicting-disease-outcome
#12
Suresh Vaikkakara, Marella Neelima Raj, Alok Sachan, Alladi Mohan, Bhuma Vengamma, P V L N Srinivas Rao, Arun Mukka, Chiruvella Sravani, Amaresh P Reddy
BACKGROUND: While elevated levels of estradiol were predictive of mortality in critically ill surgical and trauma patients, their ability to predict outcome in nonsurgical patients has not been studied. We aimed to study the determinants of gonadotropin levels in acutely ill postmenopausal women with nonsurgical disease and the impact of changes in the gonadal axis on the outcome of these patients. METHODS: Thirty-five postmenopausal women admitted to medical intensive care with acute severe illness and having a Simplified Acute Physiology Score (SAPS II score) ≥30 (in-hospital mortality rate ≥ 10%) were recruited...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28989141/melanotic-macule-in-conjunction-with-a-giant-cell-fibroma
#13
Samantha D Seitz, Thanhphuong N Dinh, Thomas Yh Yoon
INTRODUCTION: The aim of this study is to describe a case of a melanotic macule found in conjunction with a giant cell fibroma (GCF). For oral pigmented lesions without an identifiable etiologic factor, critical factors in determining the differential diagnosis are clinical history, symmetry, and uniformity of the lesions. Potential differential diagnosis includes racial pigmentation, endocrine disturbance, Peutz-Jeghers syndrome, trauma, hemochromatosis, oral malignant melanoma, or idiopathic etiology and melanotic macules...
October 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28988171/post-trauma-coping-in-the-context-of-significant-adversity-a-qualitative-study-of-young-people-living-in-an-urban-township-in-south-africa
#14
Rachel M Hiller, Sarah L Halligan, Mark Tomlinson, Jackie Stewart, Sarah Skeen, Hope Christie
OBJECTIVE: Compared with knowledge of the post-trauma needs of young people living in developed countries, little is known about the needs of those in low-middle-income countries. Such information is crucial, particularly as young people in these environments can be at increased risk of experiencing trauma, coupled with less available resources for formal support. The aim of this study was to explore post-trauma coping and support-seeking of young people living in a high-adversity settlement in South Africa...
October 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28988067/the-effect-of-resuscitation-strategy-on-the-longitudinal-immuno-inflammatory-response-to-blunt-trauma
#15
Alexander Bonde, Ask Tybjærg Nordestgaard, Rasmus Kirial, Peter Svenningsen, Martin Sillesen
INTRODUCTION: Resuscitation strategies following blunt trauma have been linked to immuno-inflammatory complications leading to systemic inflammatory syndrome (SIRS), sepsis and multiple organ failure (MOF). The effect of resuscitation strategy on longitudinal inflammation marker trajectories is, however, unknown. We hypothesized that the effect of resuscitation strategy extends beyond the trauma-related coagulopathy, perhaps affecting the longitudinal immuno-inflammatory response to injury...
September 28, 2017: Injury
https://www.readbyqxmd.com/read/28987901/quality-of-relationships-with-caregivers-depression-and-life-satisfaction-after-dysvascular-lower-extremity-amputation
#16
Moriah J Brier, Rhonda M Williams, Aaron P Turner, Alison W Henderson, Ann Marie Roepke, Daniel C Norvell, Helene Henson, Joseph M Czerniecki
OBJECTIVE: To describe the relationship between caregiver-specific support and conflict, and psychosocial outcomes among individuals experiencing their first lower extremity amputation (LEA). We hypothesized that caregiver-specific support would be associated with lower levels of depressive symptoms and higher levels of life satisfaction, and that caregiver-specific conflict would be associated with higher levels of depressive symptoms and lower levels of life satisfaction. DESIGN: Cross-sectional cohort study using self-report surveys...
October 5, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28984431/what-do-we-know-about-alara-is-our-knowledge-sufficient-about-radiation-safety
#17
Ibrahim B Atci, Hakan Yilmaz, Veysel Antar, Nuriye G Ozdemir, Oguz Baran, Sila Sadillioglu, Mehmet Ozel, Okan Turk, Mehmet Yaman, Hakan Topacoglu
BACKGROUND: The aim of this study was to determine the knowledge of neurosurgeons and emergency physicians about ALARA (as low as reasonably achievable) and to gain awareness to them about this topic. METHODS: A multiple-choice survey comprising 17 questions was performed to 30 neurosurgeons and 70 emergency room doctors. RESULTS: Emergency medicine doctors, neurosurgeons, emergency medicine residents, neurosurgery residents and general practitioners participated in the survey...
December 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28981491/the-new-zealand-major-trauma-registry-the-foundation-for-a-data-driven-approach-in-a-contemporary-trauma-system
#18
Siobhan Isles, Grant Christey, Ian Civil, Peter Hicks
AIM: To describe the development of the New Zealand Major Trauma Registry (NZ-MTR) and the initial experiences of its use. METHOD: The background to the development of the NZ-MTR was reviewed and the processes undertaken to implement a single-instance of a web-based national registry described. A national minimum dataset was defined and utilised. Key structures to support the Registry such as a data governance group were established. RESULTS: The NZ-MTR was successfully implemented and is the foundation for a new, data-driven model of quality improvement...
October 6, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28979630/sclerosing-mesenteritis-a-benign-cause-of-mesenteric-mass-lesions
#19
Diogo Carrola Gomes, Luísa Quaresma
Sclerosing mesenteritis is a rare disease of the mesentery. Associations with surgery, trauma, autoimmunity and paraneoplastic syndrome have been suggested, but most of the cases remain idiopathic. Diagnosis is often incidental, based upon the finding of a single or multiple mesenteric lesions on abdominal CT and histopathological confirmation. Optimal treatment is still controversial, but most of the cases reported have a favourable prognosis. We present a case of a 54-year-old male with long-standing abdominal pain and nausea, whose CT revealed the presence of a large mesenteric mass...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28977759/the-role-of-danger-signals-in-the-pathogenesis-and-perpetuation-of-critical-illness
#20
Kevin C Ma, Edward J Schenck, Maria A Pabon, Augustine M K Choi
The innate immune system induces inflammation through induction of multiple pathways including the TNFα/NF-κB signaling as well as the NLRP3 inflammasome cascade activation with production of inflammatory molecules. Pathogen associated molecular patterns are immunogenic costimulatory molecules that can activate the innate immune system in the presence of foreign pathogens. These molecularly distinct, foreign, particles initiate inflammatory and cell death cascades of the innate immune response through the binding of pathogen recognition receptors such as toll like receptors...
October 4, 2017: American Journal of Respiratory and Critical Care Medicine
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