keyword
MENU ▼
Read by QxMD icon Read
search

Immune system modeling

keyword
https://www.readbyqxmd.com/read/29457711/small-animal-models-for-evaluating-filovirus-countermeasures
#1
Logan Banadyga, Gary Wong, Xiangguo Qiu
The development of novel therapeutics and vaccines to treat or prevent disease caused by filoviruses, such as Ebola and Marburg viruses, depends on the availability of animal models that faithfully recapitulate clinical hallmarks of disease as it is observed in humans. In particular, small animal models (like mice and guinea pigs) are historically and frequently used for the primary evaluation of antiviral countermeasures, prior to testing in nonhuman primates, which represent the gold-standard filovirus animal model...
February 19, 2018: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29457614/poly-trimethylene-carbonate-and-poly-d-l-lactic-acid-modify-human-dendritic-cell-responses-to-staphylococci-but-do-not-affect-th1-and-th2-cell-development
#2
P P Balraadjsing, E C de Jong, D W Grijpma, M W Tanck, S A Zaat
Biomaterial-associated infections (BAIs) are frequent complications in the use of medical devices (biomaterials) correlated with considerable patient discomfort and high treatment costs. The presence of a biomaterial in the host causes derangement of local immune responses increasing susceptibility to infection. Dendritic cells (DCs) have an important role in directing the nature of immune responses by activating and controlling CD4+ T helper (Th) cell responses. To assess the immunomodulatory effect of the combined presence of biomaterials and Staphylococcus aureus (S...
February 19, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29456807/potential-of-polymeric-particles-as-future-vaccine-delivery-systems-adjuvants-for-parenteral-and-non-parenteral-immunization-against-tuberculosis-a-systematic-review
#3
REVIEW
Farzad Khademi, Mohammad Derakhshan, Arshid Yousefi-Avarvand, Mohsen Tafaghodi
Objectives: Production of effective tuberculosis (TB) vaccine is necessity. However, the development of new subunit vaccines is faced with concerns about their weak immunogenicity. To overcome such problems, polymers-based vaccine delivery systems have been proposed to be used via various routes. The purpose of this study was to determine the potential of polymeric particles as future vaccine delivery systems/adjuvants for parenteral and non-parenteral immunization against TB. Materials and Methods: PubMed, Scopus, Science-Direct, and the ISI web of knowledge databases were searched for related keywords...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456655/effect-of-immune-tolerance-induced-by-immature-dendritic-cells-and-ctla4-ig-on-systemic-lupus-erythematosus-an-in-vivo-study
#4
Cuili Huang, Lidan Zhang, Fang Ling, Sijian Wen, Yanyan Luo, Hui Liu, Jingping Liu, Wenjun Zheng, Ming Liang, Jian Sun, You-Kun Lin
Systemic lupus erythematosus (SLE) is a multi-organ autoimmune disease in which tissue damage is caused by autoantibodies. The induction of specific immune tolerance, including the utilization of immune regulatory cells, may enhance the therapeutic effects of organ transplantation in patients with SLE. Furthermore, inhibiting immune responses has been reported to be an effective treatment for SLE. However, few studies have explored the association between an increased immune tolerance and a decreased immune response in SLE treatment...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29456648/immunosuppressive-effects-of-hydroxychloroquine-and-artemisinin-combination-therapy-via-the-nuclear-factor-%C3%AE%C2%BAb-signaling-pathway-in-lupus-nephritis-mice
#5
Ning Liang, Yanchun Zhong, Jie Zhou, Bihao Liu, Ruirui Lu, Yezhi Guan, Qi Wang, Chunlin Liang, Yu He, Yuan Zhou, Jianping Song, Jiuyao Zhou
Lupus nephritis (LN) is one of the most common and severe manifestations of systemic lupus erythematosus, leading to permanent renal damage and chronic kidney disease. Hydroxychloroquine (HCQ) serves a protective role against lupus-associated clinical manifestations and medical complications; however, it results in numerous adverse reactions, limiting its long-term use. The aim of the present study was to investigate the combined effect of HCQ and artemisinin (ART) on LN, and to elucidate the underlying mechanisms...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455730/enhancement-of-oral-bioavailability-and-immune-response-of-ginsenoside-rh2-by-co-administration-with-piperine
#6
Zhao-Hui Jin, Wen Qiu, Hui Liu, Xue-Hua Jiang, Ling Wang
Ginsenoside Rh2 (Rh2) is one of the major bioactive ginsenosides in Panax ginseng. However, the oral bioavailability of Rh2 is low, with P-glycoprotein (P-gp) and CYP3A4 being reported to be the main factors. The purpose of the present study was to determine the enhancing effect of piperine on the oral bioavailability as well as bioactivity of Rh2. The inhibitory effect of piperine on P-gp and CYP3A4 was determined using a Caco-2 monolayer model and a recombinant CYP3A4 metabolic system, respectively. The pharmacokinetics of oral Rh2 (10 mg·kg-1 ) administered alone or in combination with piperine (10 and 20 mg·kg-1 ) was performed in rats...
February 2018: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/29455279/divergent-selection-of-pattern-recognition-receptors-in-mammals-with-different-ecological-characteristics
#7
Ran Tian, Meixiu Chen, Simin Chai, Xinghua Rong, Bingyao Chen, Wenhua Ren, Shixia Xu, Guang Yang
Pattern recognition receptors (PRRs) are specialized receptors that represent a key component of the host innate immune system. Whether molecular evolutionary history of different PRR classes have involved different genetic mechanisms underlying diverse pathogen environment in mammals, and whether distinct ecology of mammals may have imposed divergent selective pressures on the evolution of the PRRs, remained unknown. To test these hypotheses, we investigated the characterization of 20 genes belonging to four PRR classes in mammals...
February 17, 2018: Journal of Molecular Evolution
https://www.readbyqxmd.com/read/29454956/de-novo-transcriptome-assembly-and-analysis-of-differential-gene-expression-following-peptidoglycan-pgn-challenge-in-antheraea-pernyi
#8
Yu Liu, Zhao-Zhe Xin, Dai-Zhen Zhang, Xiao-Yu Zhu, Ying Wang, Li Chen, Bo-Ping Tang, Chun-Lin Zhou, Xin-Yue Chai, Ji-Wu Tian, Qiu-Ning Liu
Antheraea pernyi is not only an important economic insect, it is increasingly employed as a model organism due to a variety of advantages, including ease of rearing and experimental manipulation compared with other Lepidoptera. Peptidoglycan (PGN) is a major component of the bacterial cell wall, and interactions between PGN and A. pernyi cause a series of physiological changes in the insect. In the present study, we constructed cDNA libraries from a A. pernyi PGN-infected group and a control group stimulated with phosphate-buffered saline (PBS)...
February 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29454560/bioactive-lipid-mediators-profiles-in-human-psoriasis-skin-and-blood
#9
Alexander V Sorokin, Anthony Domenichiello, Amit K Dey, Aditya Goyal, Shawn M Rose, Martin P Playford, Christopher E Ramsden, Nehal N Mehta
Psoriasis (PSO) is a chronic immune-mediated disease that represents a unique model for investigating inflammation at local and systemic levels. Bioactive lipid mediators (LM) are potent compounds reported to play a role in the development and resolution of inflammation. Currently, it is not known to what extent these LM are involved in PSO pathophysiology and related metabolic dysfunction. Here we use targeted and untargeted liquid chromatography-tandem mass spectrometry (LC-MS-MS) approaches to quantify LM in skin and peripheral blood from PSO and compared them to those of healthy subjects...
February 15, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29454391/type-1-diabetes-susceptibility-alleles-are-associated-with-distinct-alterations-in-the-gut-microbiota
#10
Jane A Mullaney, Juliette E Stephens, Mary-Ellen Costello, Cai Fong, Brooke E Geeling, Patrick G Gavin, Casey M Wright, Timothy D Spector, Matthew A Brown, Emma E Hamilton-Williams
BACKGROUND: Dysbiosis of the gut microbiota has been implicated in the pathogenesis of many autoimmune conditions including type 1 diabetes (T1D). It is unknown whether changes in the gut microbiota observed in T1D are due to environmental drivers, genetic risk factors, or both. Here, we have performed an analysis of associations between the gut microbiota and T1D genetic risk using the non-obese diabetic (NOD) mouse model of T1D and the TwinsUK cohort. RESULTS: Through the analysis of five separate colonies of T1D susceptible NOD mice, we identified similarities in NOD microbiome that were independent of animal facility...
February 17, 2018: Microbiome
https://www.readbyqxmd.com/read/29453967/discovery-of-anti-viral-molecules-and-their-vital-functions-in-bombyx-mori
#11
REVIEW
Peng Lü, Ye Pan, Yanhua Yang, Feifei Zhu, Chengjun Li, Qin Yao, Keping Chen
The silkworm Bombyx mori (B. mori), a lepidopteran model organism, has become an important model for molecular biology researches with its genome completely sequenced. Silkworms confront different types of virus diseases, mainly including those caused by Bombyx mori nucleopolyhedrovirus (BmNPV), Bombyx mori densovirus type 1 (BmDNV-1), Bombyx mori bidesovirus (BmBDV) which was termed as Bombyx mori densovirus type 2 (BmDNV-2) or Bombyx mori parvo-like virus (BmPLV) before in sericulture. B. mori offers excellent models to study the molecular mechanisms of insect innate immune responses to viruses...
February 14, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29453888/dual-transcriptomics-reveals-co-evolutionary-mechanisms-of-intestinal-parasite-infections-in-blue-mussels-mytilus-edulis
#12
Marieke E Feis, Uwe John, Ana Lokmer, Pieternella C Luttikhuizen, K Mathias Wegner
On theoretical grounds, antagonistic co-evolution between hosts and their parasites should be a widespread phenomenon but only received little empirical support so far. Consequently, the underlying molecular mechanisms and evolutionary steps remain elusive, especially in non-model systems. Here, we utilised the natural history of invasive parasites to document the molecular underpinnings of co-evolutionary trajectories. We applied a dual-species transcriptomics approach to experimental cross-infections of blue mussel Mytilus edulis hosts and their invasive parasitic copepods Mytilicola intestinalis from two invasion fronts in the Wadden Sea...
February 17, 2018: Molecular Ecology
https://www.readbyqxmd.com/read/29453398/host-defense-against-oral-microbiota-by-bone-damaging-t-cells
#13
Masayuki Tsukasaki, Noriko Komatsu, Kazuki Nagashima, Takeshi Nitta, Warunee Pluemsakunthai, Chisa Shukunami, Yoichiro Iwakura, Tomoki Nakashima, Kazuo Okamoto, Hiroshi Takayanagi
The immune system evolved to efficiently eradicate invading bacteria and terminate inflammation through balancing inflammatory and regulatory T-cell responses. In autoimmune arthritis, pathogenic T H 17 cells induce bone destruction and autoimmune inflammation. However, whether a beneficial function of T-cell-induced bone damage exists is unclear. Here, we show that bone-damaging T cells have a critical function in the eradication of bacteria in a mouse model of periodontitis, which is the most common infectious disease...
February 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29452594/comparative-immunogenicity-of-preparations-of-yeast-derived-dengue-oral-vaccine-candidate
#14
Jyotiranjan Bal, Nguyen Ngoc Luong, Jisang Park, Ki-Duk Song, Yong-Suk Jang, Dae-Hyuk Kim
BACKGROUND: Dengue is listed as a neglected tropical disease by the Center for Disease Control and Preservation, as there are insufficient integrated surveillance strategies, no effective treatment, and limited licensed vaccines. Consisting of four genetically distinct serotypes, dengue virus (DENV) causes serious life-threatening infections due to its complexity. Antibody-dependent enhancement by pre-existing cross-reactive as well as homotypic antibodies further worsens the clinical symptoms of dengue...
February 16, 2018: Microbial Cell Factories
https://www.readbyqxmd.com/read/29452420/gut-microbiomics-a-solution-to-unloose-the-gordian-knot-of-biological-effects-of-ionizing-radiation
#15
Amy Zhang, Tomoko Y Steen
The Chernobyl and Fukushima nuclear accidents have called forth a growing body of research on their biological aftermaths. A variety of wild organisms, including primates, birds, fish, insects, and worms are being studied in the affected areas, with emerging morphological, physiological, and genetic aberrations ascribed to ionizing radiation. Despite the effort in surveying Chernobyl and Fukushima wildlife, little is known about the microorganisms associated with these radiation-contaminated animals. The microbiota, especially the gut commensal, plays an important role in shaping the metabolic reservoir and immune system of the host, and is sensitive to a wide array of environmental factors, including ionizing radiation...
February 14, 2018: Journal of Heredity
https://www.readbyqxmd.com/read/29452225/seminars-in-cell-and-developmental-biology-human-dendritic-cell-immunodeficiencies
#16
REVIEW
Venetia Bigley, Urszula Cytlak, Matthew Collin
The critical functions of dendritic cells (DCs) in immunity and tolerance have been demonstrated in many animal models but their non-redundant roles in humans are more difficult to probe. Human primary immunodeficiency (PID), resulting from single gene mutations, may result in DC deficiency or dysfunction. This relatively recent recognition illuminates the in vivo role of human DCs and the pathophysiology of the associated clinical syndromes. In this review, the development and function of DCs as established in murine models and human in vitro systems, is discussed...
February 13, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29452195/construction-and-evaluation-of-the-immune-protection-of-a-recombinant-divalent-protein-composed-of-the-mrpa-from-mr-p-fimbriae-and-flagellin-of-proteus-mirabilis-strain-against-urinary-tract-infection
#17
Mehri Habibi, Mohammad Reza Asadi Karam, Saeid Bouzari
Urinary tract infections (UTI) caused by Proteus mirabilis are prevalent among the catheterized patients. There is no effective vaccine to reduce the frequency of UTIs caused by P. mirabilis. In the present study, the immune responses and effectiveness of different combinations of MrpA and flagellin (FliC) of P. mirabilis were assessed intranasally in the mice model. The addition of FliC as adjuvant to MrpA in fusion form significantly raised the mucosal IgA and cellular (IFN-γ and IL-17) responses and maintained the serum IgG responses for 180 days after the first vaccination...
February 13, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29451204/conundrums-and-confusions-regarding-how-polyethylene-glycol-fusion-produces-excellent-behavioral-recovery-after-peripheral-nerve-injuries
#18
REVIEW
George D Bittner, Dale R Sengelaub, Cameron L Ghergherehchi
Current Neuroscience dogma holds that transections or ablations of a segment of peripheral nerves produce: (1) Immediate loss of axonal continuity, sensory signaling, and motor control; (2) Wallerian rapid (1-3 days) degeneration of severed distal axons, muscle atrophy, and poor behavioral recovery after many months (if ever, after ablations) by slowly-regenerating (1 mm/d), proximal-stump outgrowths that must specifically reinnervate denervated targets; (3) Poor acceptance of microsutured nerve allografts, even if tissue-matched and immune-suppressed...
January 2018: Neural Regeneration Research
https://www.readbyqxmd.com/read/29450882/the-role-of-neutrophils-in-skin-damage-induced-by-tissue-deposited-lupus-igg
#19
Xuanxuan Guo, Xiang Fang, Guodan He, M Haidar Zaman, Xibin Fei, Wei Qiao, Guo-Min Deng
Skin injury is the second most common clinical manifestation in patients with SLE. Neutrophils are crucial effector cells in immune system. The significance of neutrophils in the pathogenesis of SLE is not clear. This study is to explore the role of neutrophils in skin damage of SLE. We used lupus-prone mice and C57BL/6 mice model of lupus serum IgG induced skin inflammation to investigate neutrophils role in skin damage of SLE. We found a few neutrophils infiltrated in the inflammatory sites of skin in lupus-prone mice and lupus IgG induced skin damaged mice model...
February 16, 2018: Immunology
https://www.readbyqxmd.com/read/29450150/chemical-composition-analysis-and-in-vitro-biological-activities-of-ten-essential-oils-in-human-skin-cells
#20
Xuesheng Han, Cody Beaumont, Nicole Stevens
Research on the biological effects of essential oils on human skin cells is scarce. In the current study, we primarily explored the biological activities of 10 essential oils (nine single and one blend) in a pre-inflamed human dermal fibroblast system that simulated chronic inflammation. We measured levels of proteins critical for inflammation, immune responses, and tissue-remodeling processes. The nine single oils were distilled from Citrus bergamia (bergamot), Coriandrum sativum (cilantro), Pelargonium graveolens (geranium), Helichrysum italicum (helichrysum), Pogostemon cablin (patchouli), Citrus aurantium (petitgrain), Santalum album (sandalwood), Nardostachys jatamansi (spikenard), and Cananga odorata (ylang ylang)...
December 2017: Biochimie Open
keyword
keyword
26405
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"