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Pulmonary nodule

Heekyung Kim, Dohee Kwon, Soon Ho Yoon, Hyungjin Kim, Chang Min Park, Jin Mo Goo, Yoon Kyung Jeon, Su Yeon Ahn
OBJECTIVE: To evaluate bronchovascular injuries as the causative occurrence for clinically significant hemoptysis after percutaneous transthoracic needle biopsy (PTNB). MATERIALS AND METHODS: We included 111 consecutive patients who experienced hemoptysis after cone beam CT (CBCT)-guided PTNB from January 2014 through January 2017. Clinically significant hemoptysis was defined as hemoptysis causing hemodynamic instability or oxygen desaturation greater than 10% of baseline...
2018: PloS One
Jiali Cai, Dongming Xu, Shiyuan Liu, Matthew D Cham
Lung cancer at its earliest stage is typically manifested on computed tomography as a pulmonary nodule, which could be detected by low-dose multidetector computed tomography technology and the use of thinner collimation. Within the last 2 decades, computer-aided detection (CAD) of pulmonary nodules has been developed to meet the increasing demand for lung cancer screening computed tomography with a larger set of images per scan. This review introduced the basic techniques and then summarized the up-to-date applications of CAD systems in clinical and research programs and in the low-dose lung cancer screening trials, especially in the detection of small pulmonary nodules and missed lung cancers...
September 19, 2018: Journal of Thoracic Imaging
Omar Anjum, Helena Bleeker, Robert Ohle
INTRODUCTION: Computed tomographic pulmonary angiograms (CTPAs) are often ordered to evaluate pulmonary embolism (PE) in the emergency department (ED). The increase use of CTPA has led to an increase in incidental findings, often of low clinical significance. Our objectives were to (1) assess the prevalence and clinical significance of incidental findings identified in patients evaluated with CTPAs for PE in the ED, (2) evaluate follow-up investigations for these incidental findings, and (3) assess the utility of routine chest X-rays done prior to CTPA...
September 20, 2018: Emergency Radiology
Keitaro Nakamoto, Yuka Sasaki, Hiroyuki Kokuto, Masao Okumura, Takashi Yoshiyama, Hajime Goto
The galaxy sign and cluster sign were first reported in pulmonary sarcoidosis. From those reports, these two signs became known as one of the characteristic computed tomography (CT) findings of sarcoidosis. We report a patient with pulmonary tuberculosis who had these two signs. A 44-year-old man was referred to our hospital for general fatigue, cough, and low-grade fever lasting about two months. Thoracic CT showed a large parenchymal nodule arising from coalescent small nodules (galaxy sign) and clusters composed of numerous small nodules (cluster sign) in the bilateral lungs...
November 2018: Respirology Case Reports
Thomas James Altree, Hubertus Jersmann, Phan Nguyen
A 62-year old man with severe chronic obstructive pulmonary disease developed a persistent air leak from an iatrogenic pneumothorax following Computed Tomography-guided core biopsy of a pulmonary nodule. The pneumothorax was treated with an 8.5F intercostal catheter, which was then replaced by a 28F thoracostomy tube after development of significant subcutaneous emphysema and a tension pneumothorax. The air leak showed no improvement until endobronchial valve (EBV) insertion guided by objective flow data from a digital drainage system (DDS)...
November 2018: Respirology Case Reports
Tung-Ming Tsai, Wan-Ting Hung, Mong-Wei Lin, Hsao-Hsun Hsu, Jin-Shing Chen
PURPOSE: Uniportal video-assisted thoracoscopic surgery (VATS) has recently been reported as an alternative to conventional VATS. However, preoperative image-guided localization is usually required for small nodules. The present study evaluated the efficacy of preoperative computed tomography-guided dye localization prior to uniportal VATS for small undetermined pulmonary nodules. METHODS: We retrospectively reviewed 298 consecutive patients who underwent uniportal VATS to treat undetermined pulmonary nodules (diameter ≤ 1...
September 17, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Joel Aissa, Benedikt Michael Schaarschmidt, Janina Below, Oliver Th Bethge, Judith Böven, Lino Morris Sawicki, Norman-Philipp Hoff, Patric Kröpil, Gerald Antoch, Johannes Boos
PURPOSE: To evaluate performance and the clinical impact of a novel machine learning based vessel-suppressing computer-aided detection (CAD) software in chest computed tomography (CT) of patients with malignant melanoma. MATERIALS AND METHODS: We retrospectively included consecutive malignant melanoma patients with a chest CT between 01/2015 and 01/2016. Machine learning based CAD software was used to reconstruct additional vessel-suppressed axial images. Three radiologists independently reviewed a maximum of 15 lung nodules per patient...
September 11, 2018: Clinical Imaging
Xiyan Mu, Rutie Yin, Danqing Wang, Liang Song, Yu Ma, Xia Zhao, Qingli Li
RATIONALE: Familial hydatidiform mole is extremely rare while familial gestational trophoblastic neoplasia (GTN) has never been reported. Inspired by 2 biological sisters with postmolar GTN and liver toxicity, we reviewed susceptible maternal-effect genes and explored the role of possible drug transporter genes in the development of GTN. PATIENT CONCERNS: We reported one Chinese family where the two sisters developed postmolar GTN while experiencing fast remission and significant hepatic toxicity from actinomycin D chemotherapy...
September 2018: Medicine (Baltimore)
Yayi He, Shengxiang Ren, Yan Wang, Xuefei Li, Caicun Zhou, Fred R Hirsch
Background: MicroRNA (miRNA) is an approach for early diagnosing of cancer. We validated a panel of miRNAs (hsa-miR-199a-3p, hsa-miR-148a-3p, hsa-miR-210-3p, hsa-miR-378d and hsa-miR-138-5p) to aid early diagnosis of lung adenocarcinoma by blood test in lung cancer presenting with pulmonary nodules. Methods: A total of 369 individuals who were detected pulmonary nodules by computed tomography (CT) scan were enrolled into this study. These patients included 274 pulmonary malignant or borderline lung diseases and 122 lung benign pulmonary nodules...
August 2018: Journal of Thoracic Disease
Benoît Bédat, Etienne Abdelnour-Berchtold, Thorsten Krueger, Jean Yannis Perentes, Hans-Beat Ris, Frédéric Triponez, Marc-Joseph Licker, Wolfram Karenovics, Michel Gonzalez
Background: Pulmonary anatomical segmentectomies are increasingly being done via video-assisted thoracoscopic surgery (VATS). We analyzed clinical outcomes and risk factors for post-operative complications after pulmonary segmentectomy by VATS was introduced in two institutions. Methods: We retrospectively reviewed records of all patients who underwent anatomical pulmonary segmentectomy by VATS from 2014 to 2016 at the university hospitals of Geneva and Lausanne in Switzerland...
August 2018: Journal of Thoracic Disease
Omamah Almousa, John Mayo, John English, Richard Finley
OBJECTIVE: The purpose of this study is to determine the utility of preoperative CT-guided microcoil localization followed by fluoroscopy guided video assisted thoracoscopic resection in the diagnosis and management of small peripheral pulmonary nodules in patients with extra-thoracic malignancies. METHODS: This study is a retrospective analysis of prospectively collected data between August 2003 and September 2013. Fifty patients with extra-thoracic malignancies underwent preoperative localization of small indeterminate pulmonary nodules using CT-guided microcoil localization...
September 15, 2018: Seminars in Thoracic and Cardiovascular Surgery
H C Jo, J C Baek
Benign metastasizing leiomyoma (BML) is a rare tumor comprising histologically benign smooth muscle cells and exhibits the same histological findings as a uterine myoma although in an extra-uterine location. Most BMLs occur several years after surgery for uterine myoma in women of reproductive age. Here, we report a case of pulmonary BML in a 54-year-old postmenopausal woman with no previous history of myomectomy or hysterectomy. The patient presented with a rapid increase in abdominal girth over the past 3 months and a cough lasting for 2 months...
November 2018: Gynecologic Oncology Reports
Yoshihisa Kobayashi, Chiara Ambrogio, Tetsuya Mitsudomi
Pulmonary ground-glass nodules (GGNs) are hazy radiological findings on computed tomography (CT). GGNs are detected more often in never-smokers. Retrospective and prospective studies have revealed that approximately 20% of pure GGNs and 40% of part-solid GGNs gradually grow or increase their solid components, whereas others remain stable for years. Most persistent or growing GGNs are lung adenocarcinomas or their preinvasive lesions. To distinguish GGNs with growth from those without growth, GGNs should be followed for at least 5 years...
August 2018: Translational Lung Cancer Research
Lining Wang, Ning Li, Ling Zhou, Xiaoyan Chen, Wei Tang
Erythroderma is occasionally associated with lung cancer. Here we report a 69-year-old male who has history of melanoma from 8 years ago presented with erythroderma associated with skin, soft tissue and pulmonary infection. CT chest showed a single enlarging right upper lobe lung nodule. Biopsy showed evidence of adenocarcinoma, and eventually proven to be metastatic melanoma. The patient improved after antibiotics and antifungal treatment. To our knowledge, this is the first case of melanoma metastasis presented as erythroderma as paraneoplastic syndrome...
2018: Respiratory Medicine Case Reports
Gautham Krishnamurthy, Jayapal Rajendran, Vishal Sharma, Hemanth Kumar, Harjeet Singh
Background: Peritoneal tuberculosis has varying clinical manifestations. The study was conducted to highlight the entity of incidental peritoneal tuberculosis. Diagnostic and therapeutic dilemma is likely to occur on detection of unexpected peritoneal nodules. Materials and methodology: Incidental peritoneal tuberculosis was defined as peritoneal tuberculosis (peritoneal tubercles or ascites) detected intraoperatively in patients undergoing surgical exploration for other indications with no preoperative suspicion of abdominal tuberculosis or active tubercular lesions anywhere in the body...
September 2018: Therapeutic Advances in Infectious Disease
Masatoshi Kanayama, Masaaki Inoue, Junichi Yoshida, Fumihiro Tanaka
Situs inversus totalis is a rare clinical condition that represents a complete mirror image of the normal arrangement of the thoracic and abdominal viscera. There are very few reported cases of lung cancer patients with situs inversus totalis, but this condition requires particular care during surgery. A 61-year-old woman presented to our hospital with an abnormal shadow on chest radiography. Computed tomography revealed a 25×12 mm solitary pulmonary nodule in the left upper lobe (S2) and a complete mirror image of the normal organ arrangement, which findings met the criteria of situs inversus totalis...
2018: Journal of UOEH
Yingxue Qi, Wenchun Chen, Xinyu Liang, Ke Xu, Xiangyu Gu, Fengying Wu, Xuemei Fan, Shengxiang Ren, Junling Liu, Jun Zhang, Renhao Li, Jianwen Liu, Xin Liang
BACKGROUND: Platelet glycoprotein Ibα (GPIbα) extracellular domain, which is part of the receptor complex GPIb-IX-V, plays an important role in tumor metastasis. However, the mechanism through which GPIbα participates in the metastatic process remains unclear. In addition, potential bleeding complication remains an obstacle for the clinical use of anti-platelet agents in cancer therapy. METHODS: We established a series of screening models and obtained rat anti-mouse GPIbα monoclonal antibodies (mAb) 1D12 and 2B4 that demonstrated potential value in suppressing cancer metastasis...
September 17, 2018: Journal of Hematology & Oncology
Yafu Yin, Scott P Campbell, Mark C Markowski, Philip M Pierorazio, Martin G Pomper, Mohamad E Allaf, Steven P Rowe, Michael A Gorin
PURPOSE: To investigate the utility of prostate-specific membrane antigen (PSMA)-targeted [18 F]DCFPyL positron emission tomography (PET)/X-ray computed tomography (CT) imaging for the detection of sites of disease in patients with metastatic non-clear cell renal cell carcinoma (RCC). PROCEDURES: Eight patients with metastatic non-clear cell RCC underwent imaging with PSMA-targeted [18 F]DCFPyL PET/CT. Imaged RCC histologic subtypes included papillary RCC (n = 3), chromophobe RCC (n = 2), unclassified RCC (n = 2), and Xp11 translocation RCC (n = 1)...
September 14, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Yi Liu, Zhibin Guo, Chenlong Zhao, Xin Li, Hongyu Liu, Jun Chen
Lymphangioleiomyomatosis (LAM) is a rare disease that generally affects young women and involves the abnormal proliferation of smooth muscle-like cells (LAM cells) in the lungs (pulmonary LAM) and extrapulmonary sites (extrapulmonary LAM). This disease is rare in males. It is hard to distinguish between lung cancer and pulmonary LAM, especially during early stages. Herein, we present a case of a 66-year-old man with a small nodule in the right upper lobe that was first diagnosed as a lung malignancy using a chest CT scan...
2018: OncoTargets and Therapy
Vincenzo Venerito, Giuseppe Lopalco, Maria Grazia Anelli, Fabio Cacciapaglia, Florenzo Iannone
No abstract text is available yet for this article.
September 12, 2018: Rheumatology
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