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Pulmonary nodule

John Joseph Brady, Christie Hirsch Reilly, Robert Guay, Uday Dasika
OBJECTIVE: Because of decreased tactile sensation with thoracoscopic approaches to biopsy, localization preoperatively and intraoperatively is important for successful biopsy. Our study evaluated the technique of combined computed tomography-guided hookwire and methylene blue localization. METHODS: Seventy-five patients from November 2007 to August 2013 who underwent combined Hawkins hookwire and methylene blue localization of 76 total pulmonary nodules before video-assisted thoracic surgery-guided wedge resection were retrospectively reviewed...
June 14, 2018: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Anna Stainer, Paola Faverio, Francesca Bono, Alberto Pesci
Primary lung lymphoma (PLL) is a rare type of lymphoma confined to the lung at the time of diagnosis. Pulmonary diffuse large B cells lymphoma (P-DLBCL) is the second most common type of PLL and it usually appears radiologically as solitary or multiple nodules or areas of consolidation. We present the case of a 63-year-old Caucasian male who developed severe acute respiratory failure and diffuse ground glass opacities (GGO) on chest computerized tomography. Diffuse GGO may be the radiological expression of very different diseases, ranging from infectious processes to interstitial lung diseases (ILDs) and neoplastic diseases...
May 14, 2018: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
Behnam Jafari, Gholamabas Sabz, Elahe Masnavi, Roghaye Panahi, Saeid Jokar, Amrollah Roozbehi, Sajad Hasanzadeh
Introduction : Sarcoidosis is a granulomatous disease with unknown cause that can vary from an asymptomatic condition. Almost half of the patients with sarcoidosis have no symptoms. In this article, we describe a sarcoidosis patient with lung and liver engagement; it may be confused with metastasis. Case report : A 39-year-old man, known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment A 39-year-old man, known as hypothyroidism who had come to the emergency ward with dyspnea and coughing after exposure to detergents in a closed environment...
2018: F1000Research
Christina Söderman, Åse Allansdotter Johnsson, Jenny Vikgren, Rauni Rossi Norrlund, David Molnar, Maral Mirzai, Angelica Svalkvist, Lars Gunnar Månsson, Magnus Båth
RATIONALE AND OBJECTIVES: Chest tomosynthesis has been suggested as a suitable alternative to CT for follow-up of pulmonary nodules. The aim of the present study was to investigate the possibility of detecting pulmonary nodule growth using chest tomosynthesis. MATERIALS AND METHODS: Simulated nodules with volumes of approximately 100 mm3 and 300 mm3 as well as additional versions with increasing volumes were created. The nodules were inserted into images from pairs of chest tomosynthesis examinations, simulating cases where the nodule had either remained stable in size or increased in size between the two imaging occasions...
June 11, 2018: Academic Radiology
Zhiqiong Wang, Junchang Xin, Peishun Sun, Zhixiang Lin, Yudong Yao, Xiaosong Gao
BACKGROUND AND OBJECTIVE: Among all malignant tumors, lung cancer ranks in the top in mortality rate. Pulmonary nodule is the early manifestation of lung cancer, and plays an important role in its discovery, diagnosis and treatment. The technology of medical imaging has encountered a rapid development in recent years, thus the amount of pulmonary nodules can be discovered are on the raise, which means even tiny or minor changes in lung can be recorded by the CT images. This paper proposes a pulmonary nodule computer aided diagnosis (CAD) based on semi-supervised extreme learning machine(SS-ELM)...
August 2018: Computer Methods and Programs in Biomedicine
Christopher W Towe, Michael A Nead, Otis B Rickman, Erik E Folch, Sandeep J Khandhar, Yaron Perry, Philip A Linden
BACKGROUND: Electromagnetic navigation bronchoscopy (ENB) aids in the localization of lung lesions for biopsy and/or to guide fiducial or dye marking for stereotactic radiation or surgical localization. This study assessed ENB safety in patients with chronic obstructive pulmonary disease (COPD) and/or poor lung function. METHODS: NAVIGATE is a prospective, multicenter, observational study of ENB. This substudy analyzed the 1-month follow-up of the first 1000 enrolled subjects...
June 12, 2018: Journal of Bronchology & Interventional Pulmonology
Yoganand Balagurunathan, Andrew Beers, Jayashree Kalpathy-Cramer, Michael McNitt-Gray, Lubomir Hadjiiski, Bensheng Zhao, Jianguo Zhu, Hao Yang, Stephen S F Yip, Hugo J W L Aerts, Sandy Napel, Dmitrii Cherezov, Kenny Cha, Heang-Ping Chan, Carlos Flores, Alberto Garcia, Robert Gillies, Dmitry Goldgof
No abstract text is available yet for this article.
June 2018: Medical Physics
Paolo Albino Ferrari, Antonella Grisolia, Stefano Reale, Rosa Liotta, Alessandra Mularoni, Alessandro Bertani
BACKGROUND: Human pulmonary dirofilariasis is a rare zoonosis caused by the dog worm Dirofilaria spp., a parasite transmitted by mosquitos and resulting in peripheral lung nodules. The filarial nematode enters the subcutaneous tissue, travels to the right ventricle and dies causing a small pulmonary infarction that may embolize through the pulmonary vessels and may appear as a solitary nodule. These nodules are usually incidentally identified in asymptomatic patients undergoing chest imaging studies, and are generally interpreted to be malignant...
June 11, 2018: Journal of Cardiothoracic Surgery
Marko Weber, Jessica Rüddel, Tony Bruns, Mathias W Pletz, Andreas Stallmach
Nocardiosis is a rare infection caused by ubiquitous soil-born, acid-resistant, Gram-positive bacteria that can be life-threatening in immunocompromised patients. Originally usually diagnosed in HIV-positive patients, only few cases have been reported in patients on immunosuppressive therapy for inflammatory bowel disease or rheumatologic disorders. We present a case of a 32-year-old man who was treated with infliximab, prednisolone, and azathioprine for severe terminal ileitis. Although the clinical status improved under triple immunosuppressive therapy, weight loss, weakness, and fatigue persisted...
June 2018: Zeitschrift Für Gastroenterologie
F Fang, L Pan, L Y Bo, W P Li, E Q Fu, C C Li, F G Jin
Objective: To explore the diagnostic value and safety of endobronchial ultrasonography with guide-sheath (EBUS-GS) combined with virtual bronchoscopy navigation (VBN) in peripheral lung cancer. Methods: Between Dec. 2015 to Dec. 2016, patients with pulmonary solitary nodule suspected of early lung cancer on computed tomography (CT) in Department of Respiratory, Tangdu Hospital, Fourth Military Medical University were enrolled for this study. The patients underwent EBUS-GS transbronchoscopic lung biopsy (TBLB) with or without VBN...
June 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
Jeffrey Thiboutot, Hans J Lee, Gerard A Silvestri, Alex Chen, Momen M Wahidi, Christopher R Gilbert, Nicholas J Pastis, Jenna Los, Alexa M Barriere, Christopher Mallow, Benjamin Salwen, Marcus J Dinga, Eric L Flenaugh, Jason A Akulian, Roy Semaan, Lonny B Yarmus
BACKGROUND: Pulmonary nodules are a common but difficult issue for physicians as most identified on imaging are benign but those identified early that are cancerous are potentially curable. Multiple diagnostic options are available, ranging from radiographic surveillance, minimally invasive biopsy (bronchoscopy or transthoracic biopsy) to more invasive surgical biopsy/resection. Each technique has differences in diagnostic yield and complication rates with no established gold standard...
June 6, 2018: Contemporary Clinical Trials
Lin Lu, Yu Yue Zhao, Hong Bo Yang, Xin Lun Tian, Zuo Jun Xu, Zhao Lin Lu
BACKGROUND: Patients with Cushing's disease (CD) with hypercortisolism have an increased risk of opportunistic infection. However, most CD patients exposed to infections are diagnostic latency, leading to a poor prognosis. METHODS: Six patients in our hospital and an additional six patients in the literature were included in this study. Clinical information of CD patients with pulmonary Cryptococcus neoformans are reviewed. RESULTS: The average baseline total cortisol and ACTH in serum at 8 am of all the patients was 44...
June 5, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Laura Larrey Ruiz, Cristina Sabater Abad, Laura Peño Muñoz, Jose María Huguet Malavés, Gustavo Juan Samper
No abstract text is available yet for this article.
June 5, 2018: Archivos de Bronconeumología
Eric Abston, Robert Novaco, Stephanie Hon, Jonathan Scalera, Katrina Steiling
Extrapulmonary heterotopic ossification appears similarly to pulmonary nodules on CXR, and is in the differential for pulmonary nodules. It occurs following the bone trauma, and in early stages appears similarly to tumors. Heterotopic ossification is diagnosed by its calcification pattern via MRI or ultrasound and managed conservatively unless symptoms develop.
June 2018: Clinical Case Reports
Masamichi Koyama, Takashi Terauchi, Mitsuru Koizumi, Hiroko Tanaka, Yukiko Sato
RATIONALE: Pleomorphic adenoma, the most common tumor of the salivary glands, is usually benign. It is well known, however, that pleomorphic adenomas occasionally undergo malignant transformation to carcinoma ex pleomorphic adenoma and can metastasize. More rarely pleomorphic adenomas can metastasize without histological malignant transformation. We herein report an unusual case of pleomorphic adenoma with multiple metastases comprehensively demonstrated on F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT)...
June 2018: Medicine (Baltimore)
Naoto Aiko, Akimasa Sekine, Shigeaki Umeda, Takuma Katano, Goshi Matama, Kohsuke Isomoto, Ryota Otoshi, Takashi Ogura
Lymphomatoid granulomatosis (LYG) is a rare lung disorder diagnosed by radiological imaging of multiple pulmonary nodules and occasionally induced by methotrexate (MTX) use. To date, the treatment of LYG has not been standardized. We herein report the case of a patient with grade 3 MTX-related LYG who presented a bulky lung mass. Importantly, the disease condition only improved after the discontinuation of MTX and remained stable for more than 1 year. Chest physicians should be aware that LYG can develop as a single lung mass and spontaneously regress, even without aggressive chemotherapy, following the cessation of MTX...
June 6, 2018: Internal Medicine
Christian Andres Inchaustegui, Kevin Yuqi Wang, Oluwadamilola Teniola, Veronica Lenge De Rosen
Large septic pulmonary embolus is a rare finding in right-sided endocarditis. The entity represents a challenging diagnosis due to its variable and nonspecific clinical and radiological presentation and similarities with other conditions. We present a case of a 41 year-old woman who developed a large main pulmonary artery embolus and bilateral cavitary lung nodules in the setting of severe sepsis. Pulmonary artery exploration and clot retrieval ultimately revealed a large septic embolus from Streptococcus mutans native pulmonary valve endocarditis...
February 2018: Journal of Radiology Case Reports
Gillian A Y Haanen, Chee Kin Lim, Aubrey N Baird, Mario F Sola, Stephen D Lenz
Disseminated Rhodococcus equi infection was diagnosed in an Anglo-Nubian goat presenting for non-weight bearing lameness of the right pelvic limb. Radiographs showed a moth-eaten osteolytic lesion in the proximal tibia suggestive of an aggressive bone lesion. Two pulmonary nodules were also present on thoracic radiographs. Initial antemortem cytology of the tibial lesion was suggestive of Rhodococcosis and the goat was sent to necropsy. Necropsy and bacterial culture confirmed the diagnosis of disseminated R...
June 5, 2018: Veterinary Radiology & Ultrasound
Vanja Vučičević Boras, Dragana Gabrić, Ljiljana Smiljanić Tomičević, Sven Seiwerth, Krešimir Gršić, Božena Šarčević, Božana Lončar Brzak, Emilija Marunica, Ana Glavina
Introduction: The aim of this case report was to discuss an extremely rare oral lesion as a result of primary pulmonary tuberculosis. Case report: In this case report, the patient with refractory painless ulceration at ventral surface of the tongue was described. Detailed medical history was taken followed by clinical examination of the oral mucosa and palpation of regional lymph nodes. Clinical examination revealed ulceration on the patient's ventro-lateral surface of the tongue, approximately two centimeters in diameter...
December 2017: Acta Stomatologica Croatica
Samuel Y Ash, Rola Harmouche, James C Ross, Alejandro A Diaz, Farbod N Rahaghi, Gonzalo Vegas Sanchez-Ferrero, Rachel K Putman, Gary M Hunninghake, Jorge Onieva Onieva, Fernando J Martinez, Augustine M Choi, Russell P Bowler, David A Lynch, Hiroto Hatabu, Surya P Bhatt, Mark T Dransfield, J Michael Wells, Ivan O Rosas, Raul San Jose Estepar, George R Washko
Purpose To determine if interstitial features at chest CT enhance the effect of emphysema on clinical disease severity in smokers without clinical pulmonary fibrosis. Materials and Methods In this retrospective cohort study, an objective CT analysis tool was used to measure interstitial features (reticular changes, honeycombing, centrilobular nodules, linear scar, nodular changes, subpleural lines, and ground-glass opacities) and emphysema in 8266 participants in a study of chronic obstructive pulmonary disease (COPD) called COPDGene (recruited between October 2006 and January 2011)...
June 5, 2018: Radiology
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