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https://www.readbyqxmd.com/read/28432157/effect-of-interleukin-6-inhibition-on-coronary-microvascular-and-endothelial-function-in-myocardial-infarction
#1
Espen Holte, Ola Kleveland, Thor Ueland, Gabor Kunszt, Marte Bratlie, Kaspar Broch, Annika E Michelsen, Bjørn Bendz, Brage H Amundsen, Svend Aakhus, Jan Kristian Damås, Lars Gullestad, Pål Aukrust, Rune Wiseth
OBJECTIVE: Interleukin-6 (IL-6) is a driver of inflammation and associated endothelial cell activation in acute coronary syndromes. We evaluated the effect of the IL-6 receptor antagonist tocilizumab on coronary microvascular function and endothelial dysfunction measured by coronary flow reserve (CFR) and markers of endothelial cell activation in patients with non-ST-elevation myocardial infarction (NSTEMI). METHODS: This substudy was part of a two-centre, double-blind, randomised, placebo-controlled trial evaluating the effect of a single dose of tocilizumab in NSTEMI...
April 21, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28420647/incremental-value-of-transthoracic-doppler-echocardiography-assessed-coronary-flow-reserve-in-patients-with-suspected-myocardial-ischemia-undergoing-myocardial-perfusion-scintigraphy
#2
Li-Ming Gan, Sara Svedlund, Ann Wittfeldt, Charlotte Eklund, Sinsia Gao, Göran Matejka, Anders Jeppsson, Per Albertsson, Elmir Omerovic, Amir Lerman
BACKGROUND: Adenosine-assisted transthoracic Doppler-derived coronary flow reserve (TDE-CFR) reflects coronary vascular function. The prognostic and incremental value of left anterior descending coronary artery TDE-CFR above myocardial perfusion scintigraphy in patients with suspected myocardial ischemia has not yet been studied. METHODS AND RESULTS: Three hundred seventy-one patients (mean age, 62.3±8.7 years; 46.8% males) referred to myocardial perfusion scintigraphy attributed to suspected myocardial ischemia were included in the study...
April 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28419280/fractional-flow-reserve-and-pressure-bounded-coronary-flow-reserve-to-predict-outcomes-in-coronary-artery-disease
#3
Jung-Min Ahn, Frederik M Zimmermann, Nils P Johnson, Eun-Seok Shin, Bon-Kwon Koo, Pil Hyung Lee, Duk-Woo Park, Soo-Jin Kang, Seung-Whan Lee, Young-Hak Kim, Cheol Whan Lee, Seong-Wook Park, Nico H J Pijls, Seung-Jung Park
Aims: Fractional flow reserve (FFR) has proven to its prognostic and therapeutic value. However, the additive prognostic value of coronary flow reserve (CFR) remains unclear. This study sought to investigate the clinical utility of combined FFR and CFR measurements to predict outcomes. Methods and results: Using the prospective, multicentre Interventional Cardiology Research Incooperation Society-FFR registry, a total of 2088 lesions from 1837 patients were included in this substudy...
April 17, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28410486/how-to-treat-ebola-virus-infections-a-lesson-from-the-field
#4
REVIEW
Sophie Duraffour, Denis Malvy, Daouda Sissoko
The reported case fatality ratios (CFR) of Ebola virus disease (EVD) have been as high as 90% in previous outbreaks. While the cumulative CFR among patients medically evacuated and treated in Western countries was inferior to 20%, it peaked to approximately 75% between September and December 2014 in West Africa, thereafter decreasing to less than 40% (May 2015) without current evidence of major virus mutations capable to alter virus pathogenicity over the course of the epidemic. Therefore, the observed diminution of CFR is likely to reflect improvement of EVD patient care...
April 11, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28396479/heterogeneities-in-the-case-fatality-ratio-in-the-west-african-ebola-outbreak-2013-2016
#5
Tini Garske, Anne Cori, Archchun Ariyarajah, Isobel M Blake, Ilaria Dorigatti, Tim Eckmanns, Christophe Fraser, Wes Hinsley, Thibaut Jombart, Harriet L Mills, Gemma Nedjati-Gilani, Emily Newton, Pierre Nouvellet, Devin Perkins, Steven Riley, Dirk Schumacher, Anita Shah, Maria D Van Kerkhove, Christopher Dye, Neil M Ferguson, Christl A Donnelly
The 2013-2016 Ebola outbreak in West Africa is the largest on record with 28 616 confirmed, probable and suspected cases and 11 310 deaths officially recorded by 10 June 2016, the true burden probably considerably higher. The case fatality ratio (CFR: proportion of cases that are fatal) is a key indicator of disease severity useful for gauging the appropriate public health response and for evaluating treatment benefits, if estimated accurately. We analysed individual-level clinical outcome data from Guinea, Liberia and Sierra Leone officially reported to the World Health Organization...
May 26, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28391507/interaction-of-chronic-food-restriction-and-methylphenidate-in-sensation-seeking-of-rats
#6
Aleksandr D Talishinsky, Celine Nicolas, Satoshi Ikemoto
RATIONALE: It is necessary to understand better how chronic food restriction (CFR) and psychostimulant drugs interact in motivated behavior unrelated to food or energy homeostasis. OBJECTIVES: We examined whether CFR augments methylphenidate (MPH)-potentiated responding reinforced by visual sensation (VS) and whether repeated MPH injections or prolonged CFR further augments such responses. METHODS: Before starting the following experiments, rats on a CFR diet received a limited daily ration in such a way that their body weights decreased to 85-90% of their original weights over 2 weeks...
April 8, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28378162/coronary-flow-reserve-in-mitral-stenosis-before-and-after-percutaneous-balloon-mitral-valvuloplasty
#7
Ragab A Mahfouz, Mohammad Gouda, Waleed Elawdy, Ashraf Dewedar
We aimed to evaluate the coronary flow reserve (CFR) before and after percutaneous balloon mitral valvuloplasty (PBMV) in patients with mitral stenosis (MS) and its association to clinical events. A prospective study included 45 patients with mitral stenosis candidate for PBMV (age 38 ± 19 years, 27 were females) and 20 with matched age and sex, healthy controls were included in the study. Noninvasive CFR was measured using transthoracic echocardiography and utilizing adenosine stress echocardiography (0...
April 4, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28366469/comparison-between-carbon-peek-plate-and-conventional-stainless-steal-plate-in-ankle-fractures-a-prospective-study-of-two-years-follow-up
#8
Matteo Guzzini, Riccardo Maria Lanzetti, Domenico Lupariello, Federico Morelli, Giorgio Princi, Dario Perugia, Andrea Ferretti
INTRODUCTION: The aim of our study is to compare the clinical and radiological outcomes of the treatment of distal fibular fracture with the traditional stainless steel or the new radiolucent CFR-PEEK plates. The hypothesis is that there are no differences in clinical and radiological outcomes at the final follow-up between the two fixation devices. METHODS: All consecutive patients aged from 18 or over, who had undergone operative treatment for malleolar fracture between 2013 and 2014, have been included in the study...
March 27, 2017: Injury
https://www.readbyqxmd.com/read/28365268/diagnostic-performance-of-resting-and-hyperemic-invasive-physiological-indices-to-define-myocardial-ischemia-validation-with-13-n-ammonia-positron-emission-tomography
#9
Doyeon Hwang, Ki-Hyun Jeon, Joo Myung Lee, Jonghanne Park, Chee Hae Kim, Yaliang Tong, Jinlong Zhang, Ji-In Bang, Minseok Suh, Jin Chul Paeng, Sang-Hoon Na, Gi Jeong Cheon, Christopher M Cook, Justin E Davies, Bon-Kwon Koo
OBJECTIVES: The authors sought to compare the diagnostic performance of fractional flow reserve (FFR), instantaneous wave-free ratio (iFR), and resting distal coronary artery pressure/aortic pressure (Pd/Pa) using (13)N-ammonia positron emission tomography (PET). BACKGROUND: The diagnostic performance of invasive physiological indices was reported to be different according to the reference to define the presence of myocardial ischemia. METHODS: A total of 115 consecutive patients with left anterior descending artery stenosis who underwent both (13)N-ammonia PET and invasive physiological measurement were included...
March 24, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28362863/bacteriophage-preparation-lytic-for-shigella-significantly-reduces-shigella-sonnei-contamination-in-various-foods
#10
Nitzan Soffer, Joelle Woolston, Manrong Li, Chythanya Das, Alexander Sulakvelidze
ShigaShield™ is a phage preparation composed of five lytic bacteriophages that specifically target pathogenic Shigella species found in contaminated waters and foods. In this study, we examined the efficacy of various doses (9x105-9x107 PFU/g) of ShigaShield™ in removing experimentally added Shigella on deli meat, smoked salmon, pre-cooked chicken, lettuce, melon and yogurt. The highest dose (2x107 or 9x107 PFU/g) of ShigaShield™ applied to each food type resulted in at least 1 log (90%) reduction of Shigella in all the food types...
2017: PloS One
https://www.readbyqxmd.com/read/28362383/methodology-for-the-study-of-horizontal-gene-transfer-in-staphylococcus-aureus
#11
Fabio Cafini, Nguyen Thi Le Thuy, Federico Román, José Prieto, Sarah Dubrac, Tarek Msadek, Kazuya Morikawa
One important feature of the major opportunistic human pathogen Staphylococcus aureus is its extraordinary ability to rapidly acquire resistance to antibiotics. Genomic studies reveal that S. aureus carries many virulence and resistance genes located in mobile genetic elements, suggesting that horizontal gene transfer (HGT) plays a critical role in S. aureus evolution. However, a full and detailed description of the methodology used to study HGT in S. aureus is still lacking, especially regarding natural transformation, which has been recently reported in this bacterium...
March 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28353034/coronary-flow-capacity-concept-promises-and-challenges
#12
Tim P van de Hoef, Mauro Echavarría-Pinto, Javier Escaned, Jan J Piek
The vasodilator capacity of the coronary circulation is an important diagnostic and prognostic characteristic, and its accurate assessment is therefore an important frontier. The coronary flow capacity (CFC) concept was introduced to overcome the limitations associated with the use of coronary flow reserve (CFR) for this purpose, which are related to the sensitivity of CFR to physiological alterations in systemic and coronary hemodynamics. CFC was developed from positron emission tomography, and was subsequently extrapolated to invasive coronary physiology...
March 28, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28350706/a-posting-peculiarity
#13
Brant A Ulsh, Ed Bradley
The definitions of "radiation area," "high radiation area," and "very high radiation area," provided by the U.S. Department of Energy in 10 CFR Part 835.2, and by the Nuclear Regulatory Commission in 10 CFR Part 20.1003, appear to require redundant posting. This is counterintuitive and would be confusing if the regulations were followed as currently written. We suspect that this is unintentional. However, until the relevant regulations are revised, it is recommended that licensees request written clarification from the regulators to ensure that they are able to demonstrate regulatory compliance...
May 2017: Health Physics
https://www.readbyqxmd.com/read/28318875/feasibility-of-pet-for-the-management-of-coronary-artery-disease-comparison-between-cfr-and-ffr
#14
REVIEW
Osamu Manabe, Masanao Naya, Nagara Tamaki
Myocardial perfusion imaging using positron emission tomography (PET) allows both qualitative and quantitative measurement. The quantitative myocardial blood flow and coronary flow reserve (CFR) are reliable indices for evaluating functional severity, influenced by both epicardial stenosis and microvascular disease. Fractional flow reserve (FFR) also reflects physiological stenosis, which measures the pressure differences across a coronary artery stenosis during maximum hyperemia. Discordance between CFR and FFR has been noticed in estimating the functional significance of coronary stenosis...
March 16, 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/28316350/peek-and-cfr-peek-as-alternative-bearing-materials-to-uhmwpe-in-a-fixed-bearing-total-knee-replacement-an-experimental-wear-study
#15
Claire L Brockett, Silvia Carbone, John Fisher, Louise M Jennings
New bearing materials for total joint replacement have been explored as the need to improve longevity and enhance performance is driven by the changing demands of the patient demographic. Carbon-reinforced PEEK has demonstrated good wear characteristics in experimental wear simulation in both simple geometry pin-on-plate studies and in total hip joint replacement. Carbon reinforced PEEK CFR-PEEK has the potential to reduce tibial insert thickness and preserve bone in the knee. This study investigated the wear performance of PEEK and CFR-PEEK in a low conformity total knee replacement configuration...
March 15, 2017: Wear: An International Journal on the Science and Technology of Friction Lubrication and Wear
https://www.readbyqxmd.com/read/28306335/prognostic-value-of-normal-positron-emission-tomography-myocardial-perfusion-imaging-in-patients-with-known-or-suspected-coronary-artery-disease-a-meta-analysis
#16
A'Di Chen, HaoSen Wang, Bing Fan, YaWei Xu, Wei Chen, Neng Dai
OBJECTIVE: Several studies have confirmed high diagnostic performance of positron emission tomography (PET) myocardial perfusion imaging (MPI) in patients with known or suspected coronary artery disease (CAD). However, whether the superior diagnostic accuracy could translate into improved mortality outcomes remains unknown. The aim of this study was to define the prognostic value of normal PET MPI. METHODS: PubMed and EMBASE were searched to identify related studies up to June 2016...
March 17, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28300369/perturbation-effects-of-the-carbon-fiber-peek-screws-on-radiotherapy-dose-distribution
#17
Alexander Nevelsky, Egor Borzov, Shahar Daniel, Raquel Bar-Deroma
Radiation therapy, in conjunction with surgical implant fixation, is a common combined treatment in cases of bone metastases. However, metal implants generally used in orthopedic implants perturb radiation dose distributions. Carbon-Fiber Reinforced Polyetheretherketone (CFR-PEEK) material has been recently introduced for production of intramedullary nails and plates. The purpose of this work was to investigate the perturbation effects of the new CFR-PEEK screws on radiotherapy dose distributions and to evaluate these effects in comparison with traditional titanium screws...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296167/what-can-intracoronary-pressure-measurements-tell-us-about-flow-reserve-pressure-bounded-coronary-flow-reserve-and-example-application-to-the-randomized-defer-trial
#18
Frederik M Zimmermann, Nico H J Pijls, Bernard De Bruyne, G Jan-Willem Bech, Pepijn van Schaardenburgh, Richard L Kirkeeide, K Lance Gould, Nils P Johnson
OBJECTIVE: We propose a novel technique called pressure-bounded coronary flow reserve (pb-CFR) and demonstrate its application to the randomized DEFER trial. BACKGROUND: Intracoronary flow reserve assessment remains underutilized relative to pressure measurements partly due to less robust tools. METHODS: While rest and hyperemic intracoronary pressure measurements cannot quantify CFR exactly, they do provide upper and lower bounds. We validated pb-CFR invasively against traditional CFR, then applied it to high fractional flow reserve (FFR ≥ 0...
March 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28294860/-coronary-flow-reserve-in-the-left-anterior-and-posterior-descending-arteries-as-an-additional-option-to-dipyridamole-stress-echocardiography-for-detection-of-stenosis
#19
A A Boshchenko, A V Vrublevsky, R S Karpov
AIM: to assess additive diagnostic value of simultaneous evaluation of coronary flow reserve (CFR) in the left anterior descending (LAD) artery and posterior descending artery (PDA) during dipyridamole stress echocardiography (stress-Echo) for detection of LAD and PDA stenoses >50%. METHODS: 108 in-patients (mean age 50+/-11 years) with cardiac chest pain underwent dipyridamole stress-Echo with ECG-analysis, wall motion analysis by 2-dimentional imaging (2D) and coronary flow reserve (CFR) evaluation in both LAD and PDA by pulse-wave Doppler...
April 2016: Kardiologiia
https://www.readbyqxmd.com/read/28293706/coronary-atherosclerotic-burden-vs-coronary-vascular-function-in-diabetic-and-nondiabetic-patients-with-normal-myocardial-perfusion-a-propensity-score-analysis
#20
Roberta Assante, Wanda Acampa, Emilia Zampella, Parthiban Arumugam, Carmela Nappi, Valeria Gaudieri, Mariarosaria Panico, Mario Magliulo, Christine M Tonge, Mario Petretta, Alberto Cuocolo
PURPOSE: To assess the relationship between coronary atherosclerotic burden and vascular function in diabetic and nondiabetic patients after balancing for coronary risk factors. METHODS: We studied 672 patients without overt coronary artery disease and normal myocardial perfusion on stress (82)Rb PET/CT imaging. To account for differences in baseline characteristics between diabetic patients and nondiabetic patients, we created a propensity score-matched cohort considering clinical variables and coronary risk factors...
March 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
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