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https://www.readbyqxmd.com/read/28733080/cyclic-fatigue-resistance-of-reciproc-blue-and-reciproc-files-in-an-s-shaped-canal
#1
Hüseyin Sinan Topçuoğlu, Gamze Topçuoğlu
INTRODUCTION: This study evaluated the cyclic fatigue resistance (CFR) of Reciproc (R25 and R40; VDW, Munich, Germany) and Reciproc Blue (R25 and R40, VDW) instruments used in an artificial S-shaped canal. METHODS: A total of 80 files were tested in an S-shaped canal (n = 20 for each file, Reciproc R25 and R40 and Reciproc Blue R25 and R40). This study compared Reciproc R25 with Reciproc Blue R25 files and Reciproc R40 with Reciproc Blue R40 files. All files were rotated in an S-shaped artificial canal until fracture...
July 18, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28721626/fate-of-antimicrobial-resistance-genes-in-response-to-application-of-poultry-and-swine-manure-in-simulated-manure-soil-microcosms-and-manure-pond-microcosms
#2
Mianzhi Wang, Yongxue Sun, Peng Liu, Jing Sun, Qin Zhou, Wenguang Xiong, Zhenling Zeng
This study aimed to determine the occurrence, abundance, and fate of nine important antimicrobial resistance genes (ARGs) (sul1, sul2, tetB, tetM, ermB, ermF, fexA, cfr, and Intl1) in the simulated soil and pond microcosms following poultry and swine manure application. Absolute quantitative PCR method was used to determine the gene copies. The results were modeled as a logarithmic regression (N = mlnt + b) to explore the fate of target genes. Genes sul1, Intl1, sul2, and tetM had the highest abundance following the application of the two manure types...
July 18, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28721014/determining-optimal-dosing-regimen-of-oral-administration-of-dicloxacillin-using-monte-carlo-simulation
#3
Wei Yu, Jinru Ji, Tingting Xiao, Chaoqun Ying, Jiaheng Fang, Ping Shen, Yonghong Xiao
BACKGROUND: Dicloxacillin, a semisynthetic isoxazolyl penicillin, exhibits antimicrobial activity against a wide variety of Gram-positive bacteria, as well as stability against penicillinases and low level of toxicity. The objective of this study was to obtain optimal dosing regimen of oral administration of dicloxacillin by analyzing the pharmacokinetic (PK) index in healthy volunteers and in vitro antibacterial activity by using Monte Carlo simulation. MATERIALS AND METHODS: A total of 867 clinical isolates from community-onset infections were collected from 31 secondary hospitals in People's Republic of China...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28709989/evaluating-biapenem-dosage-regimens-in-intensive-care-unit-patients-with-pseudomonas-aeruginosa-infections-a-pharmacokinetic-pharmacodynamic-analysis-using-monte-carlo-simulation
#4
Yongfu Hang, Yafang Chen, Ling Xue, Shusen Sun, Long Liu, Jie Gao, Cheng Xie, Xianfeng Zhang, Jianguo Zhu, Jun Jin, Liyan Miao
This study sought to both identify optimal dosage regimens and estimate pharmacokinetic/pharmacodynamics characteristics of short-infusion (SI) versus extended-infusion (EI) for the use of biapenem against Pseudomonas aeruginosa infections in Chinese Intensive Care patients. A total of 85 strains of P. aeruginosa were collected, and the minimum inhibitory concentration (MIC) of biapenem was measured by the serial two-fold agar dilution method. We designed four frequently used clinical regimens: biapenem 300mg I...
July 11, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28707168/acupuncture-for-cancer-related-fatigue-in-lung-cancer-patients-a-randomized-double-blind-placebo-controlled-pilot-trial
#5
Chien-Shan Cheng, Lian-Yu Chen, Zhou-Yu Ning, Chen-Yue Zhang, Hao Chen, Zhen Chen, Xiao-Yan Zhu, Jing Xie
BACKGROUND: Cancer-related fatigue (CRF) is a distressing symptom that is the most common unpleasant side effect experienced by lung cancer patients and is challenging for clinical care workers to manage. METHODS: We performed a randomized, double-blind, placebo-controlled pilot trial to evaluate the clinical effect of acupuncture on CRF in lung cancer patients. Twenty-eight patients presenting with CRF were randomly assigned to active acupuncture or placebo acupuncture groups to receive acupoint stimulation (LI-4, Ren-6, St-36, KI-3, and Sp-6) twice per week for 4 weeks, followed by 2 weeks of follow-up...
July 13, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28707049/locking-screw-plate-interface-stability-in-carbon-fibre-reinforced-polyetheretherketone-proximal-humerus-plates
#6
David J Hak, Ryan Fader, Todd Baldini, Vivek B S Chadayammuri
PURPOSE: Carbon-fibre reinforced polyetheretherketone (CFR-PEEK) plates have recently been introduced for proximal humerus fracture treatment. The purpose of this study was to compare the locking screw-plate interface stability in CFR-PEEK versus stainless steel (SS) proximal humerus plates. METHODS: Locking screw mechanical stability was evaluated independently in proximal and shaft plate holes. Stiffness and load to failure were tested for three conditions: (1) on-axis locking screw insertion in CFR-PEEK versus SS plates, (2) on-axis locking screw insertion, removal, and reinsertion in CFR-PEEK plates, and (3) 10-degree off-axis locking screw insertion in CFR-PEEK plates...
July 13, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28704695/emergence-of-the-asian-genotype-of-denv-1-in-south-india
#7
D Cecilia, J A Patil, M B Kakade, A Walimbe, K Alagarasu, B Anukumar, A Abraham
A large outbreak of dengue occurred in Tamil Nadu, South India in 2012 with 12,000 cases and CFR of 0.5%. Molecular characterization of virus present in the sera of dengue patients was undertaken to determine if there were changes in the virus population. All four serotypes were circulating but DENV-1 was dominant, present in 52% of the serotyped samples. Furthermore, the genotype of only DENV-1 had changed; the Asian genotype had displaced the American/African. Phylogenetic analysis revealed that the Asian genotype was introduced from Singapore and shared 99% similarity with viruses, associated with large outbreaks in Singapore and Sri Lanka...
July 10, 2017: Virology
https://www.readbyqxmd.com/read/28699843/social-workers-have-an-obligation-to-all-patients-regarding-confidentiality-%C3%A2-however-for-some-patients-the-obligation-is-greater
#8
Karlynn BrintzenhofeSzoc, Caitlyn Gilbert
Social workers are held to many ethical obligations regarding patients including maintaining patient confidentiality and staying up to date on confidentiality laws, statutes, and regulations. As the landscape of health care continues to change, including the increased use of technology to maintain patient records, highlights this need. The changes in the regulations on confidentiality of those who are receiving substance use treatment, 42 CFR Part 2, are presented. The other regulations and laws covered include HIPAA, HITECH, and the ACA...
July 12, 2017: Social Work in Health Care
https://www.readbyqxmd.com/read/28698020/first-outbreak-of-colonization-by-linezolid-and-glycopeptide-resistant-enterococcus-faecium-harbouring-the-cfr-gene-in-a-uk-nephrology-unit
#9
Teresa Inkster, John Coia, Danièle Meunier, Michel Doumith, Kate Martin, Rachel Pike, Laura Imrie, Hayley Kane, Marlene Hay, Camilla Wiuff, Julie Wilson, Chris Deighan, Katie L Hopkins, Neil Woodford, Robert Hill
AIM: To describe an outbreak of colonization by linezolid- and glycopeptide-resistant Enterococcus faecium harbouring the cfr gene, in a UK nephrology unit. METHODS: Isolates of linezolid-resistant E. faecium were typed by PFGE and examined by PCR and sequencing for the transmissible cfr gene that confers resistance to linezolid. Enhanced environmental cleaning, initial and weekly screening of all patients and monitoring of adherence to standard infection control precautions (SICPs) were implemented...
July 8, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28675967/survival-of-a-native-toxigenic-isolate-of-listeria-monocytogenes-cfr-1302-during-storage-of-milk-based-foods-can-be-a-potential-cause-of-health-risk
#10
Hampapura S Jayanth, Mandyam C Varadaraj
The ability of a native toxigenic culture of Listeria monocytogenes CFR 1302 to survive and elaborate associated toxigenic trait in ice cream and mango pulp-based lactic fermented milk was studied. The culture of L. monocytogenes inoculated at two initial levels of 4.6 and 5.6 log10 CFU/ml almost remained unaltered during storage of the food products. However, in both the milk-based products, a marginal increase in viable population was observed during 2-4 d of storage as against the initial inoculum levels...
July 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/28663361/hyperaemic-microvascular-resistance-predicts-clinical-outcome-and-microvascular-injury-after-myocardial-infarction
#11
Guus A de Waard, Gregor Fahrni, Douwe de Wit, Hironori Kitabata, Rupert Williams, Niket Patel, Paul F Teunissen, Peter M van de Ven, Sabahattin Umman, Paul Knaapen, Divaka Perera, Takashi Akasaka, Murat Sezer, Rajesh K Kharbanda, Niels van Royen
OBJECTIVES: Early detection of microvascular dysfunction after acute myocardial infarction (AMI) could identify patients at high risk of adverse clinical outcome, who may benefit from adjunctive treatment. Our objective was to compare invasively measured coronary flow reserve (CFR) and hyperaemic microvascular resistance (HMR) for their predictive power of long-term clinical outcome and cardiac magnetic resonance (CMR)-defined microvascular injury (MVI). METHODS: Simultaneous intracoronary Doppler flow velocity and pressure measurements acquired immediately after revascularisation for AMI from five centres were pooled...
June 29, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28663250/association-between-elevated-pulse-pressure-and-high-resting-coronary-blood-flow-velocity-in-patients-with-angiographically-normal-epicardial-coronary-arteries
#12
Maria Lembo, Rosa Sicari, Roberta Esposito, Fausto Rigo, Lauro Cortigiani, Francesco Lo Iudice, Eugenio Picano, Bruno Trimarco, Maurizio Galderisi
BACKGROUND: The aim of our study was to evaluate the relationship of pulse pressure (PP), a raw index of arterial stiffness, with noninvasively determined coronary flow reserve (CFR) and its components, in patients with angiographically normal epicardial coronary arteries. METHODS AND RESULTS: The study population included 398 patients without angiographic evidence of coronary stenosis, who underwent high-dose dipyridamole stress echocardiography with transthoracic-derived CFR evaluation on the left anterior descending artery...
June 29, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28663118/acfr-like-gene-cfr-c-conferring-linezolid-resistance-is-common-in-clostridium-difficile
#13
Thomas Candela, Jean-Christophe Marvaud, Tiep Khac Nguyen, Thierry Lambert
Clostridium difficile T10 and Clostridium bolteae 90B3 were co-resistant to phenicols, lincosamides, oxazolidinones, pleuromutilins and streptogramin A (PhLOPSA) and harbored an unreported cfr-like determinant that may alter the 23S rRNA by m(8)A2503 methylation. The cfr-like named cfr(C) gene was cloned in C. difficile 630Δerm in which it conferred PhLOPSA resistance. In C. bolteae 90B3: (i) qRT-PCR analysis indicated that cfr(C) was similarly expressed in the absence of or in the presence of either chloramphenicol or clindamycin or linezolid; (ii) cfr(C) was part of a putative 24 kb-transposon, which generated a detectable circular intermediate...
June 26, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28662397/oxidation-of-%C3%AE-lactam-antibiotics-by-peracetic-acid-reaction-kinetics-product-and-pathway-evaluation
#14
Kejia Zhang, Xinyan Zhou, Penghui Du, Tuqiao Zhang, Meiquan Cai, Peizhe Sun, Ching-Hua Huang
Peracetic acid (PAA) is a disinfection oxidant used in many industries including wastewater treatment. β-Lactams, a group of widely prescribed antibiotics, are frequently detected in wastewater effluents and surface waters. The reaction kinetics and transformation of seven β-lactams (cefalexin (CFX), cefadroxil (CFR), cefapirin (CFP), cephalothin (CFT), ampicillin (AMP), amoxicillin (AMX) and penicillin G (PG)) toward PAA were investigated to elucidate the behavior of β-lactams during PAA oxidation processes...
June 22, 2017: Water Research
https://www.readbyqxmd.com/read/28653394/ranolazine-reduces-repolarization-heterogeneity-in%C3%A2-symptomatic-patients-with-diabetes-and-non-flow-limiting-coronary-artery-stenosis
#15
Ederson Evaristo, Fernando G Stocco, Nishant R Shah, Michael K Cheezum, Jon Hainer, Courtney Foster, Bruce D Nearing, Marcelo Di Carli, Richard L Verrier
BACKGROUND: Experimental evidence suggests that ranolazine decreases susceptibility to ischemia-induced arrhythmias independent of effects on coronary artery blood flow. OBJECTIVE: In symptomatic diabetic patients with non-flow-limiting coronary artery stenosis with diffuse atherosclerosis and/or microvascular dysfunction, we explored whether ranolazine reduces T-wave heterogeneity (TWH), an electrocardiographic (ECG) marker of arrhythmogenic repolarization abnormalities shown to predict sudden cardiac death...
June 27, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28653312/link-of-renal-microcirculatory-dysfunction-to-increased-coronary-microcirculatory-resistance-in-hypertensive-patients
#16
Cong Lin, Pu Zhang, Yangjing Xue, Yinqing Huang, Kangting Ji
BACKGROUND: This study investigated the correlation between renal microcirculation and coronary microcirculation in hypertensive patients. METHODS: Participants consisted of 231 consecutive candidates who were referred to the Second Affiliated Hospital of Wenzhou Medical University from March 2014 to May 2016 for elective coronary angiography due to suspected myocardial ischemia. All participants were evaluated for the index of microvascular resistance (IMR), coronary flow reserve (CFR), and fractional flow reserve (FFR) using a pressure wire...
June 27, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/28640836/craniofacial-similarity-analysis-through-sparse-principal-component-analysis
#17
Junli Zhao, Fuqing Duan, Zhenkuan Pan, Zhongke Wu, Jinhua Li, Qingqiong Deng, Xiaona Li, Mingquan Zhou
The computer-aided craniofacial reconstruction (CFR) technique has been widely used in the fields of criminal investigation, archaeology, anthropology and cosmetic surgery. The evaluation of craniofacial reconstruction results is important for improving the effect of craniofacial reconstruction. Here, we used the sparse principal component analysis (SPCA) method to evaluate the similarity between two sets of craniofacial data. Compared with principal component analysis (PCA), SPCA can effectively reduce the dimensionality and simultaneously produce sparse principal components with sparse loadings, thus making it easy to explain the results...
2017: PloS One
https://www.readbyqxmd.com/read/28630201/the-combined-effect-of-the-cfr-methyltransferase-and-ribosomal-protein-l3-mutations-on-resistance-to-ribosome-targeting-antibiotics
#18
Kevin K Pakula, Lykke H Hansen, Birte Vester
Several groups of antibiotics inhibit bacterial growth by binding to bacterial ribosomes. Mutations in the ribosomal protein L3 have been associated with resistance to linezolid and tiamulin, which both bind at the peptidyl transferase center in the ribosome. Resistance to these and other antibiotics also occurs through methylation of 23S ribosomal RNA at position A2503 by the methyltransferase Cfr. The mutations in L3 and the cfr gene have been found together in clinical isolates, raising the question whether they provide a combined effect on antibiotic resistance or growth...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28629394/validating-the-who-maternal-near-miss-tool-comparing-high-and-low-resource-settings
#19
Tom Witteveen, Hans Bezstarosti, Ilona de Koning, Ellen Nelissen, Kitty W Bloemenkamp, Jos van Roosmalen, Thomas van den Akker
BACKGROUND: WHO proposed the WHO Maternal Near Miss (MNM) tool, classifying women according to several (potentially) life-threatening conditions, to monitor and improve quality of obstetric care. The objective of this study is to analyse merged data of one high- and two low-resource settings where this tool was applied and test whether the tool may be suitable for comparing severe maternal outcome (SMO) between these settings. METHODS: Using three cohort studies that included SMO cases, during two-year time frames in the Netherlands, Tanzania and Malawi we reassessed all SMO cases (as defined by the original studies) with the WHO MNM tool (five disease-, four intervention- and seven organ dysfunction-based criteria)...
June 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28629382/community-first-responders-and-responder-schemes-in-the-united-kingdom-systematic-scoping-review
#20
Viet-Hai Phung, Ian Trueman, Fiona Togher, Roderick Orner, A Niroshan Siriwardena
BACKGROUND: Community First Responder (CFR) schemes support lay people to respond to medical emergencies, working closely with ambulance services. They operate widely in the UK. There has been no previous review of UK literature on these schemes. This is the first systematic scoping review of UK literature on CFR schemes, which identifies the reasons for becoming a CFR, requirements for training and feedback and confusion between the CFR role and that of ambulance service staff. This study also reveals gaps in the evidence base for CFR schemes...
June 19, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
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