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https://www.readbyqxmd.com/read/28923876/co-location-of-the-multiresistance-gene-cfr-and-the-fosfomycin-resistance-gene-fosd-on-a-novel-plasmid-in-staphylococcus-arlettae-from-chicken-farm
#1
Bi-Hui Liu, Chang-Wei Lei, An-Yun Zhang, Yun Pan, Ling-Han Kong, Rong Xiang, Yong-Xiang Wang, Yan-Xian Yang, Hong-Ning Wang
A novel 63,558-bp plasmid pSA-01 harbouring nine antibiotic resistance genes, including cfr, erm(C), tet(L), erm(T), aadD, fosD, fexB, aacA-aphD and erm(B), was characterized in Staphylococcus arlettae strain SA-01 isolated from chicken farm in China. The co-location of cfr and fosD genes was detected for the first time in S. arlettae plasmid. The detection of two IS431-mediated circular forms containing resistance genes in SA-01 suggested that IS431 may facilitate dissemination of antibiotic resistance genes...
September 18, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28911764/global-respiratory-syncytial-virus-associated-mortality-in-young-children-rsv-gold-a-retrospective-case-series
#2
Nienke M Scheltema, Angela Gentile, Florencia Lucion, D James Nokes, Patrick K Munywoki, Shabir A Madhi, Michelle J Groome, Cheryl Cohen, Jocelyn Moyes, Kentigern Thorburn, Somsak Thamthitiwat, Hitoshi Oshitani, Socorro P Lupisan, Aubree Gordon, José F Sánchez, Katherine L O'Brien, Bradford D Gessner, Agustinus Sutanto, Asuncion Mejias, Octavio Ramilo, Najwa Khuri-Bulos, Natasha Halasa, Fernanda de-Paris, Márcia Rosane Pires, Michael C Spaeder, Bosco A Paes, Eric A F Simões, Ting F Leung, Maria Tereza da Costa Oliveira, Carla Cecília de Freitas Lázaro Emediato, Quique Bassat, Warwick Butt, Hsin Chi, Uzma Bashir Aamir, Asad Ali, Marilla G Lucero, Rodrigo A Fasce, Olga Lopez, Barbara A Rath, Fernando P Polack, Jesse Papenburg, Srđan Roglić, Hisato Ito, Edward A Goka, Diederick E Grobbee, Harish Nair, Louis J Bont
BACKGROUND: Respiratory syncytial virus (RSV) infection is an important cause of pneumonia mortality in young children. However, clinical data for fatal RSV infection are scarce. We aimed to identify clinical and socioeconomic characteristics of children aged younger than 5 years with RSV-related mortality using individual patient data. METHODS: In this retrospective case series, we developed an online questionnaire to obtain individual patient data for clinical and socioeconomic characteristics of children aged younger than 5 years who died with community-acquired RSV infection between Jan 1, 1995, and Oct 31, 2015, through leading research groups for child pneumonia identified through a comprehensive literature search and existing research networks...
October 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28905060/an-engineering-approach-to-synthesis-of-gold-and-silver-nanoparticles-by-controlling-hydrodynamics-and-mixing-based-on-a-coaxial-flow-reactor
#3
Razwan Baber, Luca Mazzei, Nguyen Thi Kim Thanh, Asterios Gavriilidis
In this work we present a detailed study of flow technology approaches that could open up new possibilities for nanoparticle synthesis. The synthesis of gold and silver nanoparticles (NPs) in a flow device based on a coaxial flow reactor (CFR) was investigated. The CFR comprised of an outer glass tube of 2 mm inner diameter (I.D.) and an inner glass tube whose I.D. varied between 0.142 and 0.798 mm. A split and recombine (SAR) mixer and coiled flow inverter (CFI) were further employed to alter the mixing conditions after the CFR...
September 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28904700/descriptive-epidemiology-of-a-cholera-outbreak-in-kaduna-state-northwest-nigeria-2014
#4
Ibrahim Baffa Sule, Mohammed Yahaya, Abubakar Ahmed Aisha, Ahmed Datti Zainab, Bajoga Ummulkhulthum, Patrick Nguku
INTRODUCTION: Cholera is an acute gastrointestinal infection caused by Vibrio cholerae, which may lead to severe dehydration and death if not treated. This analysis is aimed at highlighting the magnitude, pattern and trend of cholera outbreak that occurred in Kaduna State in 2014. METHODS: We obtained the 2014 cholera line-list from the Kaduna State Disease Surveillance and Notification officer (DSNO). We described the outbreaks in time, place and person using Epi-info 7 and Health Mapper...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904692/evaluation-of-bacterial-meningitis-surveillance-data-of-the-northern-region-ghana-2010-2015
#5
Basil Benduri Kaburi, Chrysantus Kubio, Ernest Kenu, Donne Kofi Ameme, Jacob Yakubu Mahama, Samuel Oko Sackey, Edwin Andrew Afari
INTRODUCTION: Bacterial meningitis is a disease of major public health importance especially for countries such as Ghana; whose northern part lies within the meningitis belt. The Northern region of Ghana has been recording cases with outbreaks over the years. In order to generate evidence to improve surveillance, we described the epidemiology of bacterial meningitis using surveillance data of the northern region. METHODS: Bacterial meningitis datasets from January 2010 to December 2015 for all the 26 districts of the Northern region were retrieved from line lists...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28898725/maximum-insertion-torque-of-a-novel-implant-abutment-interface-design-for-peek-dental-implants
#6
Andreas Dominik Schwitalla, Tycho Zimmermann, Tobias Spintig, Mohamed Abou-Emara, Justus Lackmann, Wolf-Dieter Müller, Alireza Houshmand
Frequent reports attest to the various advantages of tapered implant/abutment interfaces (IAIs) compared to other types of interfaces. For this reason, a conical IAI was designed as part of the development of a PEEK (polyetheretherketone)-based dental implant. This IAI is equipped with an apically displaced anti-rotation lock with minimal space requirements in the form of an internal spline. The objective of this study was the determination of the average insertion torque (IT) at failure of this design, so as to determine its suitability for immediate loading, which requires a minimum IT of 32Ncm...
September 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28884833/circulatory-flow-restoration-versus-cardiopulmonary-resuscitation-new-therapeutic-approach-in-sudden-cardiac-arrest
#7
Sayed Nour, Daniel Carbognani, Juan Carlos Chachques
Sudden cardiac arrest (SCA) remains a major problem for health authorities worldwide. Insufficiencies of current cardiopulmonary resuscitation (CPR) are most probably related to an inappropriate concept and applied methods that still concentrate on heartbeat as priority, instead of blood circulation to maintain organs' perfusions. The aim of this works is to propose a new therapeutic approach for SCA in a more effective and secure manner compared with current CPR methods. It correlates to a non-invasive circulatory flow restoration (CFR) device composed of a multilayered thoracic and infradiaphragmatic compartments that will be pulsated alternatively and in fixed frequencies using a low-pressure pneumatic generator...
September 8, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28884804/frequent-and-parallel-habitat-transitions-as-driver-of-unbounded-radiations-in-the-cape-flora
#8
Yanis Bouchenak-Khelladi, H Peter Linder
The enormous species richness in the Cape Floristic Region (CFR) of Southern Africa is the result of numerous radiations, but the temporal progression and possible mechanisms of these radiations are still poorly understood. Here, we explore the macroevolutionary dynamics of the Restionaceae, that include 340 species which are found in all vegetation types in the Cape flora and are ecologically dominant in fynbos. Using an almost complete (i.e. 98%) species-level time calibrated phylogeny and models of diversification dynamics, we show that species diversification is constant through the Cenozoic, with no evidence of an acceleration with the onset of the modern winter-wet climate, or a recent density-dependent slowdown...
September 8, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/28864442/integrated-non-invasive-physiological-assessment-of-coronary-circulatory-function-and-impact-on-cardiovascular-mortality-in-patients-with-stable-coronary-artery-disease
#9
Ankur Gupta, Viviany R Taqueti, Tim P van de Hoef, Navkaranbir S Bajaj, Paco E Bravo, Venkatesh L Murthy, Michael T Osborne, Sara B Seidelmann, Tomas S Vita, Courtney F Bibbo, Meagan Harrington, Jon Hainer, Ornella Rimoldi, Sharmila Dorbala, Deepak L Bhatt, Ron Blankstein, Paolo G Camici, Marcelo F Di Carli
Background -It is suggested that the integration of maximal myocardial blood flow (MBF) and coronary flow reserve (CFR), termed coronary flow capacity, allows comprehensive evaluation of patients with known or suspected stable coronary artery disease. As management decisions are predicated on clinical risk, we sought to determine the independent and integrated value of maximal MBF and CFR for predicting cardiovascular death. Methods -MBF and CFR were quantified in 4,029 consecutive patients (median age 66 years, 50...
September 1, 2017: Circulation
https://www.readbyqxmd.com/read/28857738/detection-of-high-levels-of-resistance-to-linezolid-and-vancomycin-in-staphylococcus-aureus
#10
Aysha Azhar, Samreen Rasool, Asma Haque, Sidra Shan, Muhammad Saeed, Beenish Ehsan, Abdul Haque
Both methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive S. aureus (MSSA) are rapidly overcoming the current array of drugs. One hundred and fifty isolates from a hospital were studied for resistance towards linezolid and vancomycin. Fifty-four (36.0 %) isolates were MRSA. Both MRSA and MSSA showed high resistance towards linezolid when using the disc diffusion method, with the figures being 48.1 and 29.2 %, respectively. The figures for the E-test were 46.3 and 27.0 %, respectively...
September 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28851731/exploring-coronary-circulatory-response-to-stenosis-and-its-association-with-invasive-physiologic-indices-using-absolute-myocardial-blood-flow-and-coronary-pressure
#11
Joo Myung Lee, Doyeon Hwang, Jonghanne Park, Jinlong Zhang, Yaliang Tong, Chee Hae Kim, Ji-In Bang, Minseok Suh, Jin Chul Paeng, Gi Jeong Cheon, Bon-Kwon Koo
Background -Although invasive physiologic assessment for coronary stenosis has become a standard practice to guide treatment strategy, coronary circulatory response and changes in invasive physiologic indices, according to different anatomical and hemodynamic lesion severity, have not been fully demonstrated in patients with coronary artery disease. Methods -One hundred fifteen patients with left anterior descending artery stenosis who underwent both (13)N-ammonia positron emission tomography (PET) and invasive physiologic measurement were analyzed...
August 29, 2017: Circulation
https://www.readbyqxmd.com/read/28829938/fluoride-ion-release-of-self-adhesive-resin-cements-and-their-potential-to-inhibit-in-situ-enamel-and-dentin-demineralization
#12
V A Pellizzari, A C Michels, S T Luiz, E M de Souza, Cpm Tabchoury, R N Rached
OBJECTIVE: This study evaluated in situ the potential of a glass ionomer and self-adhesive resin cements to inhibit enamel and dentin demineralization around indirect restorations exposed to cariogenic challenge. The cumulative fluoride release (CFR) of materials was measured in water and acid. METHODS: Seventy blocks cut from human molars received two indirect composite restorations (one in enamel and another in dentin) luted with Ketac Cem EasyMix (GIC, positive control), SeT (SeT), Maxcem Elite (Max), Smart Cem2 (Smart), and RelyX Unicem 2 (Unicem2)...
September 2017: Operative Dentistry
https://www.readbyqxmd.com/read/28817662/single-scan-rest-stress-imaging-with-99mtc-sestamibi-and-cadmium-zinc-telluride-based-spect-for-hyperemic-flow-quantification-a-feasibility-study-evaluated-with-cardiac-magnetic-resonance-imaging
#13
Yu-Hua Dean Fang, Yuan-Chang Liu, Kung-Chu Ho, Feng-Cheng Kuo, Ching-Fang Yang, Tzu-Chen Yen, I-Chang Hsieh
INTRODUCTION: We aimed to evaluate whether the hyperemic myocardial blood flow (MBF) can be estimated using cadmium zinc telluride (CZT)-based single-photon emission computed tomography (SPECT) cameras with a single, rapid rest/stress dynamic scan. Dynamic contrast-enhanced (DCE) cardiac magnetic resonance imaging (MRI) was used as a reference modality for flow measurement. MATERIALS AND METHODS: The proposed protocol included both the rest and stress acquisitions within a 24-min scan...
2017: PloS One
https://www.readbyqxmd.com/read/28815357/carbon-fiber-reinforced-peek-fixation-system-in-the-treatment-of-spine-tumors-a-preliminary-report
#14
Stefano Boriani, Giuseppe Tedesco, Lu Ming, Riccardo Ghermandi, Maurizio Amichetti, Piero Fossati, Marco Krengli, Loredana Mavilla, Alessandro Gasbarrini
BACKGROUND: Protocols including combination of surgery and radiotherapy are more and more frequent in the treatment of bone tumors of the spine. In metastatic disease, combination of surgery and radiotherapy is since long time accepted, as based on clinical evidence. In primary tumors, combination of surgery and radiotherapy can be considered in all the cases in which a satisfactory oncological margin cannot be achieved: high-grade malignancies, recurrent tumors, huge tumors expanding in an extracompartimental area, and when tumor-free margin requires unacceptable functional sacrifices...
August 16, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28815291/prognostic-value-of-atherosclerotic-burden-and-coronary-vascular-function-in-patients-with-suspected-coronary-artery-disease
#15
Roberta Assante, Wanda Acampa, Emilia Zampella, Parthiban Arumugam, Carmela Nappi, Valeria Gaudieri, Ciro Gabriele Mainolfi, Mariarosaria Panico, Mario Magliulo, Christine M Tonge, Mario Petretta, Alberto Cuocolo
PURPOSE: To evaluate the prognostic value of coronary atherosclerotic burden, assessed by coronary artery calcium (CAC) score, and coronary vascular function, assessed by coronary flow reserve (CFR) in patients with suspected coronary artery disease (CAD). METHODS: We studied 436 patients undergoing hybrid (82)Rb positron emission tomography/computed tomography imaging. CAC score was measured according to the Agatston method, and patients were categorized into three groups (0, <400, and ≥400)...
August 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28805176/estimating-the-risk-of-invasive-group-a-streptococcus-infection-in-care-home-residents-in-england-2009-2010
#16
M Saavedra-Campos, B Simone, S Balasegaram, A Wright, M Usdin, T Lamagni
Invasive group A streptococcal (iGAS) infections cause severe disease and death, especially in residents of long-term care facilities (LTCFs). In order to inform iGAS prevention, we compared the risk of iGAS in LTCF residents and community residents. We identified LTCF residents among cases of iGAS from national surveillance (2009-2010) using postcode matching, and cases of hospital-acquired infections via hospital admission records. We used Poisson regression to calculate incidence rate ratios (IRR) and logistic regression to explore factors associated with case fatality rate (CFR)...
August 14, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28797469/multivariate-statistical-process-control-in-product-quality-review-assessment%C3%A2-%C3%A2-a-case-study
#17
M Kharbach, Y Cherrah, Y Vander Heyden, A Bouklouze
According to the Food and Drug Administration and the European Good Manufacturing Practices (GMP) guidelines, Annual Product Review (APR) is a mandatory requirement in GMP. It consists of evaluating a large collection of qualitative or quantitative data in order to verify the consistency of an existing process. According to the Code of Federal Regulation Part 11 (21 CFR 211.180), all finished products should be reviewed annually for the quality standards to determine the need of any change in specification or manufacturing of drug products...
August 7, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/28797357/stress-perfusion-coronary-flow-reserve-versus-cardiac-magnetic-resonance-for-known%C3%A2-or%C3%A2-suspected-cad
#18
Shingo Kato, Naka Saito, Tatsuya Nakachi, Kazuki Fukui, Tae Iwasawa, Masataka Taguri, Masami Kosuge, Kazuo Kimura
BACKGROUND: Phase-contrast (PC) cine magnetic resonance imaging (MRI) of the coronary sinus is a noninvasive method to quantify coronary flow reserve (CFR). OBJECTIVES: This study sought to compare the prognostic value of CFR by cardiac magnetic resonance (CMR) and stress perfusion CMR to predict major adverse cardiac events (MACE). METHODS: Participants included 276 patients with known coronary artery disease (CAD) and 400 with suspected CAD...
August 15, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28793891/characterizing-measles-transmission-in-india-a-dynamic-modeling-study-using-verbal-autopsy-data
#19
Stéphane Verguet, Edward O Jones, Mira Johri, Shaun K Morris, Wilson Suraweera, Cindy L Gauvreau, Prabhat Jha, Mark Jit
BACKGROUND: Decreasing trends in measles mortality have been reported in recent years. However, such estimates of measles mortality have depended heavily on assumed regional measles case fatality risks (CFRs) and made little use of mortality data from low- and middle-income countries in general and India, the country with the highest measles burden globally, in particular. METHODS: We constructed a dynamic model of measles transmission in India with parameters that were empirically inferred using spectral analysis from a time series of measles mortality extracted from the Million Death Study, an ongoing longitudinal study recording deaths across 2...
August 10, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28776314/a-combined-static-dynamic-single-dose-imaging%C3%A2-protocol-to-compare-quantitative-dynamic-spect-with-static-conventional-spect
#20
Maria Sciammarella, Uttam M Shrestha, Youngho Seo, Grant T Gullberg, Elias H Botvinick
BACKGROUND: SPECT myocardial perfusion imaging (MPI) is a clinical mainstay that is typically performed with static imaging protocols and visually or semi-quantitatively assessed for perfusion defects based upon the relative intensity of myocardial regions. Dynamic cardiac SPECT presents a new imaging technique based on time-varying information of radiotracer distribution, which permits the evaluation of regional myocardial blood flow (MBF) and coronary flow reserve (CFR). In this work, a preliminary feasibility study was conducted in a small patient sample designed to implement a unique combined static-dynamic single-dose one-day visit imaging protocol to compare quantitative dynamic SPECT with static conventional SPECT for improving the diagnosis of coronary artery disease (CAD)...
August 3, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
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