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https://www.readbyqxmd.com/read/28542866/pharmacokinetic-pharmacodynamic-evaluation-of-marbofloxacin-as-a-single-injection-for-pasteurellaceae-respiratory-infections-in-cattle-using-population-pharmacokinetics-and-monte-carlo-simulations
#1
A Paulin, M Schneider, F Dron, F Woehrle
Population pharmacokinetic of marbofloxacin was investigated with 52 plasma concentration-time profiles obtained after intramuscular administration of Forcyl® in cattle. Animal's status, pre-ruminant, ruminant, or dairy cow, was retained as a relevant covariate for clearance. Monte Carlo simulations were performed using a stratification by status, and 1000 virtual disposition curves were generated in each bovine subpopulation for the recommended dosage regimen of 10 mg/kg as a single injection. The probability of target attainment (PTA) of pharmacokinetic/pharmacodynamic (PK/PD) ratios associated with clinical efficacy and prevention of resistance was determined in each simulated subpopulation...
May 19, 2017: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28542014/oak-ridge-reservation-environmental-protection-rad-neshaps-radionuclide-inventory-web-database-and-rad-neshaps-source-and-dose-database
#2
Patricia A Scofield, Linda L Smith, David N Johnson
The U.S. Environmental Protection Agency promulgated national emission standards for emissions of radionuclides other than radon from US Department of Energy facilities in Chapter 40 of the Code of Federal Regulations (CFR) 61, Subpart H. This regulatory standard limits the annual effective dose that any member of the public can receive from Department of Energy facilities to 0.1 mSv. As defined in the preamble of the final rule, all of the facilities on the Oak Ridge Reservation, i.e., the Y-12 National Security Complex, Oak Ridge National Laboratory, East Tennessee Technology Park, and any other U...
July 2017: Health Physics
https://www.readbyqxmd.com/read/28540633/olfactory-neuroblastoma-a-single-center-experience
#3
Marton König, Terje Osnes, Peter Jebsen, Jan Folkvard Evensen, Torstein R Meling
Olfactory neuroblastoma (ONB) is a potentially curable disease, despite being an aggressive malignancy with a poor natural history. Our goal was to evaluate management outcomes for patients with ONB treated at our institution. Our prospective database for brain tumors and the pathology registry of head and neck cancers at Oslo University Hospital were searched to identify all patients treated for ONB between 1998 and 2016. Variables extracted from these databases, supplemented by retrospective chart reviews, underwent thorough analysis...
May 25, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28539854/the-effect-of-hydrofluoric-acid-surface-treatment-on-the-cyclic-fatigue-resistance-of-k3-niti-instruments
#4
Kee-Yeon Kum, Seok Woo Chang
The aim of this study was to investigate the effect of 50% hydrofluoric acid (HF) surface treatment on the cyclic fatigue resistance (CFR) of K3 NiTi instruments. Twenty as-received and twenty HF-treated K3 NiTi instruments were compared in CFR. The surface texture and fracture surface of two instrument groups were examined with a scanning electron microscope (SEM). Additionally, any change of Ni and Ti composition from both instrument groups was investigated using energy dispersive spectrometry. The results were analyzed with t-test...
2017: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/28536574/erratum-distribution-of-cfr-in-staphylococcus-spp-and-escherichia-coli-strains-from-pig-farms-in-china-and-characterization-of-a-novel-cfr-carrying-f43-a-b-plasmid
#5
(no author information available yet)
[This corrects the article on p. 329 in vol. 8, PMID: 28293235.].
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28524024/-efficacy-and-safety-of-colistimethate-sodium-in-critical-patients-an-in-vitro-study-by-using-of-monte-carlo-simulation
#6
Aijun Pan, Qing Mei, Tianjun Yang, Xiaolan Gao, Huaiwei Lu, Ying Ye, Jiabin Li, Bao Liu
OBJECTIVE: To evaluate the efficacy and safety of colistimethate sodium (CMS) for the treatment of critical patients infected by pan-drug resistant Acinetobacter baumannii (PDR-AB) or pan-drug resistant Pseudomonas aeruginosa (PDR-PA). METHODS: 321 isolates of PDR-AB and 204 isolates of PDR-PA from critical patients admitted to 35 intensive care units (ICUs) of grade two or above were collected from the Anhui Antimicrobial Resistance Investigation Net (AHARIN) program from September 2012 to September 2015, while the minimal inhibitory concentrations (MIC) of colistin were determined by the E-test...
May 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28521932/discordance-between-fractional-flow-reserve-and-coronary-flow-reserve-insights-from-intracoronary-imaging-and-physiological%C3%A2-assessment
#7
Sung Gyun Ahn, Jon Suh, Olivia Y Hung, Hee Su Lee, Yasir H Bouchi, Wenjie Zeng, Rounak Gandhi, Parham Eshtehardi, Bill D Gogas, Habib Samady
OBJECTIVES: The aim of this study was to investigate the epicardial and microvascular substrates associated with discordances between fractional flow reserve (FFR) and coronary flow reserve (CFR) values. BACKGROUND: Discordances between FFR and CFR remain poorly characterized. METHODS: FFR, hyperemic stenosis resistance (HSR), and intravascular ultrasound were performed as indexes of epicardial function and CFR and hyperemic microvascular resistance (HMR) as measures of microvascular function in 94 patients with moderate coronary stenosis...
May 22, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28520758/cumulative-family-risks-across-income-levels-predict-deterioration-of-children-s-general-health-during-childhood-and-adolescence
#8
Yi-Ching Lin, Dong-Chul Seo
Family is considered an important agent in the health development of children. This process is significant but quite complex because the prevalence of potential risk factors in the family can hinder children's health. This study examined if multiple family risks might have cumulative effect on children and youth's health across various levels of household income. The data in this study were drawn from the 2011-2012 U.S. National Survey of Children's Health (N = 79,601). A cumulative family risk (CFR) index was developed, which included such constructs as single-parenthood, unstable employment, large family, parenting stress, poor maternal education, poor maternal general health and poor maternal mental health...
2017: PloS One
https://www.readbyqxmd.com/read/28514327/postoperative-assessment-of-myocardial-function-and-microcirculation-in-patients-with-acute-coronary-syndrome-by-myocardial-contrast-echocardiography
#9
Li Jiang, Hong Yao, Zhao-Guang Liang
BACKGROUND Postoperative myocardial function and microcirculation of acute coronary syndrome (ACS) was assessed by myocardial contrast echocardiography (MCE). MATERIAL AND METHODS Eighty-nine ACS patients treated with percutaneous coronary intervention (PCI) were detected by MCE and two-dimensional ultrasonography before and a month later after PCI respectively. Their myocardial perfusion was evaluated by myocardial contrast score (MSC) and contrast score index (CSI); cross-sectional area of microvessel (A), average myocardial microvascular impairment (β), and myocardial blood flow (MBF) were analyzed by cardiac ultrasound quantitative analysis (CUSQ), and fractional flow reserve (FFR) change was observed...
May 17, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28506254/reemergence-of-yellow-fever-in-ethiopia-after-50%C3%A2-years-2013-epidemiological-and-entomological-investigations
#10
Abrham Lilay, Negga Asamene, Abyot Bekele, Mesfin Mengesha, Milliyon Wendabeku, Israel Tareke, Abiy Girmay, Yonas Wuletaw, Abate Adossa, Yamar Ba, Amadou Sall, Daddi Jima, Debritu Mengesha
BACKGROUND: Yellow Fever (YF) is a viral hemorrhagic disease transmitted by aedes mosquito species. Approximately, 200,000 cases and 30,000 deaths occur worldwide every year. In Ethiopia, the last outbreak was reported in 1966 with 2200 cases and 450 deaths. A number of cases with deaths from unknown febrile illness reported from South Ari district starting from November 2012. This investigation was conducted to identify the causative agent, source of the outbreak and recommend appropriate interventions...
May 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28500229/isolation-by-distance-and-isolation-by-environment-contribute-to-population-differentiation-in-protea-repens-proteaceae-l-a-widespread-south-african-species
#11
Rachel Prunier, Melis Akman, Colin T Kremer, Nicola Aitken, Aaron Chuah, Justin Borevitz, Kent E Holsinger
PREMISE OF THE STUDY: The Cape Floristic Region (CFR) of South Africa is renowned for its botanical diversity, but the evolutionary origins of this diversity remain controversial. Both neutral and adaptive processes have been implicated in driving diversification, but population-level studies of plants in the CFR are rare. Here, we investigate the limits to gene flow and potential environmental drivers of selection in Protea repens L. (Proteaceae L.), a widespread CFR species. METHODS: We sampled 19 populations across the range of P...
May 12, 2017: American Journal of Botany
https://www.readbyqxmd.com/read/28487838/impact-of-high-serum-immunoglobulin-e-levels-on-the-risk-of-atherosclerosis-in-humans
#12
Derya Unal, Aslı Gelincik, Ali Elitok, Semra Demir, Müge Olgac, Raif Coskun, Mehmet Kocaaga, Bahattin Colakoglu, Suna Buyukozturk
BACKGROUND: Epidemiological studies show that immunoglobulin E (IgE) levels were higher in subjects with acute coronary events. However, it is unknown if the increased IgE level is a marker of future coronary incidents and whether it may be regarded as a risk factor of an ischemic heart disease. OBJECTIVE: Our aim was to investigate the relationship between IgE levels and some atherosclerotic markers in patients without known atherosclerotic disease. METHODS: Fifty patients (mean age, 40...
April 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/28486995/antimicrobial-resistance-and-virulence-characterization-of-staphylococcus-aureus-and-coagulase-negative-staphylococci-from-imported-beef-meat
#13
Kamelia Osman, Avelino Alvarez-Ordóñez, Lorena Ruiz, Jihan Badr, Fatma ElHofy, Khalid S Al-Maary, Ihab M I Moussa, Ashgan M Hessain, Ahmed Orabi, Alaa Saad, Mohamed Elhadidy
BACKGROUND: The objectives of this study were to characterize the diversity and magnitude of antimicrobial resistance among Staphylococcus species recovered from imported beef meat sold in the Egyptian market and the potential mechanisms underlying the antimicrobial resistance phenotypes including harboring of resistance genes (mecA, cfr, gyrA, gyrB, and grlA) and biofilm formation. RESULTS: The resistance gene mecA was detected in 50% of methicillin-resistant non-Staphylococcus aureus isolates (4/8)...
May 10, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28485281/influence-of-the-amount-of-myocardium-subtended-to-a-coronary-stenosis-on-the-index-of-microcirculatory-resistance-implications-for-the-invasive-assessment-of-microcirculatory-function-in-ischemic-heart-disease
#14
Mauro Echavarría-Pinto, Tim P van de Hoef, Sukhjinder Nijjer, Nieves Gonzalo, Luis Nombela-Franco, Borja Ibañez, Sayan Sen, Ricardo Petraco, Pilar Jimenez-Quevedo, Ivan J Nuñez-Gil, Enrico Cerrato, Pablo Salinas, Alicia Quirós, Hector M Garcia-Garcia, Antonio Fernandez-Ortiz, Carlos Macaya, Justin Davies, Jan Piek, Javier Escaned
AIMS: The index of microcirculatory resistance (IMR) is growingly used to quantify microcirculatory function. However, in normal coronary arteries, resistance increases with the branching structure of the coronary tree, which suggest that IMR could be influenced by the amount of downstream myocardial mass (MM). We aimed to evaluate the influence of the amount of MM subtended to an intermediate stenosis on the IMR. METHODS AND RESULTS: IMR, fractional flow reserve and coronary flow reserve (CFR) were measured in 123 coronary arteries (102 patients) with intermediate stenosis...
May 9, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28485068/wear-resistance-of-poly-2-methacryloyloxyethyl-phosphorylcholine-grafted-carbon-fiber-reinforced-poly-ether-ether-ketone-liners-against-metal-and-ceramic-femoral-heads
#15
Shihori Yamane, Masayuki Kyomoto, Toru Moro, Masami Hashimoto, Yoshio Takatori, Sakae Tanaka, Kazuhiko Ishihara
Younger, active patients who undergo total hip arthroplasty (THA) have increasing needs for wider range of motion and improved stability of the joint. Therefore, bearing materials having not only higher wear resistance but also mechanical strength are required. Carbon fiber-reinforced poly(ether ether ketone) (CFR-PEEK) is known as a super engineering plastic that has great mechanical strength. In this study, we focused on poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)-grafted CFR-PEEK and investigated the effects of PMPC grafting and the femoral heads materials on the wear properties of CFR-PEEK liners...
May 9, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28483950/in-vitro-activity-of-linezolid-against-clinically-important-gram-positive-cocci-in-the-united-states-a-5-year-summary-of-in-vitro-activity-and-resistance-mechanisms-from-the-leader-surveillance-program-2011-2015
#16
Michael A Pfaller, Rodrigo E Mendes, Jennifer M Streit, Patricia A Hogan, Robert K Flamm
This study describes linezolid susceptibility testing results for 6,741 gram-positive pathogens from 60 U.S. sites collected during 2015 for the LEADER Program. In addition, the study summarizes linezolid in vitro activity, resistance mechanisms, and molecular typing obtained for 2011 to 2015. During 2015, linezolid showed potent activity when tested against Staphylococcus aureus, inhibiting >99.9% of 3,031 isolates at ≤2 mg/liter. Similarly, linezolid showed coverage against 99.2% of coagulase-negative staphylococci, 99...
May 8, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28473401/ranolazine-in-symptomatic-diabetic-patients-without-obstructive-coronary-artery-disease-impact-on-microvascular-and-diastolic-function
#17
Nishant R Shah, Michael K Cheezum, Vikas Veeranna, Stephen J Horgan, Viviany R Taqueti, Venkatesh L Murthy, Courtney Foster, Jon Hainer, Karla M Daniels, Jose Rivero, Amil M Shah, Peter H Stone, David A Morrow, Michael L Steigner, Sharmila Dorbala, Ron Blankstein, Marcelo F Di Carli
BACKGROUND: Treatments for patients with myocardial ischemia in the absence of angiographic obstructive coronary artery disease are limited. In these patients, particularly those with diabetes mellitus, diffuse coronary atherosclerosis and microvascular dysfunction is a common phenotype and may be accompanied by diastolic dysfunction. Our primary aim was to determine whether ranolazine would quantitatively improve exercise-stimulated myocardial blood flow and cardiac function in symptomatic diabetic patients without obstructive coronary artery disease...
May 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28472396/chronic-activation-of-hypothalamic-oxytocin-neurons-improves-cardiac-function-during-left-ventricular-hypertrophy-induced-heart-failure
#18
Kara Garrott, Jhansi Dyavanapalli, Edmund Cauley, Mary Kate Dwyer, Sarah Kuzmiak-Glancy, Xin Wang, David Mendelowitz, Matthew Kay
AIMS: A distinctive hallmark of heart failure (HF) is autonomic imbalance, consisting of increased sympathetic activity and decreased parasympathetic tone. Recent work suggests that activation of hypothalamic oxytocin (OXT) neurons could improve autonomic balance during HF. We hypothesized that a novel method of chronic selective activation of hypothalamic OXT neurons will improve cardiac function and reduce inflammation and fibrosis in a rat model of HF. METHODS AND RESULTS: Two groups of male Sprague-Dawley rats underwent trans-ascending aortic constriction (TAC) to induce left ventricular (LV) hypertrophy that progresses to HF...
May 2, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28471255/reducing-the-cost-of-caring-in-cancer-care-evaluation-of-a-pilot-interprofessional-compassion-fatigue-resiliency-programme
#19
Kathryn A Pfaff, Laurie Freeman-Gibb, Linda J Patrick, Rita DiBiase, Olivia Moretti
Compassion fatigue (CF) is a combination of secondary traumatic stress and burnout. Empathy becomes depleted among professional caregivers due to repeated exposure to emotional pain. Negative effects include decreased general wellbeing, impaired caregiver health and diminished team functioning. Intervention is needed to support caregiver quality of life and team relationships in high-stress work environments. This pilot study evaluated the impact of a pilot CF resiliency (CFR) programme on interprofessional staff at a regional cancer centre...
May 4, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28466053/analyzing-the-clinical-profile-of-swine-flu-influenza-a-h1n1-infection-in-central-india-a-retrospective-study
#20
Sameer Arbat, Mitesh Dave, Vinit Niranjane, Irfan Rahman, Ashok Arbat
Recently, India reported an increase in swine flu (influenza A H1N1) activity. There are limited studies on epidemiology of swine flu in Indian context. This study aims to analyze clinical and epidemiological profile of suspected swine flu cases in central India. 171 cases were included in a hospital based, observational, descriptive study conducted from December 2014 to April 2015. Demographics, clinical presentation and outcome of positive and negative cases were compared. Data was analyzed using STATA software...
March 2017: Virusdisease
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