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https://www.readbyqxmd.com/read/28640836/craniofacial-similarity-analysis-through-sparse-principal-component-analysis
#1
Junli Zhao, Fuqing Duan, Zhenkuan Pan, Zhongke Wu, Jinhua Li, Qingqiong Deng, Xiaona Li, Mingquan Zhou
The computer-aided craniofacial reconstruction (CFR) technique has been widely used in the fields of criminal investigation, archaeology, anthropology and cosmetic surgery. The evaluation of craniofacial reconstruction results is important for improving the effect of craniofacial reconstruction. Here, we used the sparse principal component analysis (SPCA) method to evaluate the similarity between two sets of craniofacial data. Compared with principal component analysis (PCA), SPCA can effectively reduce the dimensionality and simultaneously produce sparse principal components with sparse loadings, thus making it easy to explain the results...
2017: PloS One
https://www.readbyqxmd.com/read/28630201/the-combined-effect-of-the-cfr-methyltransferase-and-ribosomal-protein-l3-mutations-on-resistance-to-ribosome-targeting-antibiotics
#2
Kevin K Pakula, Lykke H Hansen, Birte Vester
Several groups of antibiotics inhibit bacterial growth by binding to bacterial ribosomes. Mutations in the ribosomal protein L3 have been associated with resistance to linezolid and tiamulin, which both bind at the peptidyl transferase center in the ribosome. Resistance to these and other antibiotics also occurs through methylation of 23S ribosomal RNA at position A2503 by the methyltransferase Cfr. The mutations in L3 and the cfr gene have been found together in clinical isolates, raising the question whether they provide a combined effect on antibiotic resistance or growth...
June 19, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28629394/validating-the-who-maternal-near-miss-tool-comparing-high-and-low-resource-settings
#3
Tom Witteveen, Hans Bezstarosti, Ilona de Koning, Ellen Nelissen, Kitty W Bloemenkamp, Jos van Roosmalen, Thomas van den Akker
BACKGROUND: WHO proposed the WHO Maternal Near Miss (MNM) tool, classifying women according to several (potentially) life-threatening conditions, to monitor and improve quality of obstetric care. The objective of this study is to analyse merged data of one high- and two low-resource settings where this tool was applied and test whether the tool may be suitable for comparing severe maternal outcome (SMO) between these settings. METHODS: Using three cohort studies that included SMO cases, during two-year time frames in the Netherlands, Tanzania and Malawi we reassessed all SMO cases (as defined by the original studies) with the WHO MNM tool (five disease-, four intervention- and seven organ dysfunction-based criteria)...
June 19, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28629382/community-first-responders-and-responder-schemes-in-the-united-kingdom-systematic-scoping-review
#4
Viet-Hai Phung, Ian Trueman, Fiona Togher, Roderick Orner, A Niroshan Siriwardena
BACKGROUND: Community First Responder (CFR) schemes support lay people to respond to medical emergencies, working closely with ambulance services. They operate widely in the UK. There has been no previous review of UK literature on these schemes. This is the first systematic scoping review of UK literature on CFR schemes, which identifies the reasons for becoming a CFR, requirements for training and feedback and confusion between the CFR role and that of ambulance service staff. This study also reveals gaps in the evidence base for CFR schemes...
June 19, 2017: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/28617855/stroke-in-hiv-infected-individuals-with-and-without-hcv-coinfection-in-spain-in-the-combination-antiretroviral-therapy-era
#5
Alejandro Alvaro-Meca, Juan Berenguer, Asunción Díaz, Dariela Micheloud, Teresa Aldámiz-Echevarría, Chiara Fanciulli, Salvador Resino
The incidence of stroke in human immunodeficiency virus (HIV)-infected individuals has been well analyzed in recent epidemiological studies. However, little is known about the specific contribution of hepatitis C virus (HCV) infection to stroke among HIV-infected individuals. The aims of this study were to analyze trends in the incidence rates of stroke in HIV-infected individuals during the combination antiretroviral (cART) era in Spain and to categorize them by the presence or absence of HCV coinfection. We analyzed hospital discharges with a diagnosis of stroke in Spain according to ICD-9-CM during 1997-2013...
2017: PloS One
https://www.readbyqxmd.com/read/28607025/pharmacodynamic-evaluation-of-fosfomycin-against-e-coli-and-klebsiella-spp-from-urinary-tract-infections-and-the-influence-of-ph-on-fosfomycin-activities
#6
Nayara Helisandra Fedrigo, Josmar Mazucheli, James Albiero, Danielle Rosani Shinohara, Fernanda Gomes Lodi, Ana Cristina Dos Santos Machado, Sherwin K B Sy, Maria Cristina Bronharo Tognim
Fosfomycin is widely used for the treatment of uncomplicated urinary tract infection (UTI) and recently have been recommended for treating multidrug-resistant (MDR) gram-negative bacilli. Whether urine acidification can improve bacterial susceptibility to fosfomycin oral dosing regimen has not been analyzed. Minimal inhibitory concentration (MIC) was determined using agar dilution in pH 6.0 and 7.0 for 245 Gram negative bacterial isolates, consisting of 158 E. coli and 87 Klebsiella spp. which were collected from patients with UTI...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28605483/vedolizumab-in-pediatric-inflammatory-bowel-disease-a-retrospective-multi-center-experience-from-the-paediatric-ibd-porto-group-of-espghan
#7
Oren Ledder, Amit Assa, Arie Levine, Johanna C Escher, Lissy de Ridder, Frank Ruemmele, Neil Shah, Ron Shaoul, Victorien M Wolters, Astor Rodrigues, Holm H Uhlig, Carsten Posovsky, Kaija-Leena Kolho, Christian Jakobsen, Shlomi Cohen, Dror S Shouval, Tim de Meij, Javier Martin-de-Carpi, Lisa Richmond, Jiri Bronsky, Mira Friedman, Dan Turner
Background: Vedolizumab, an anti-integrin antibody, has proven to be effective in adults with Inflammatory Bowel Disease (IBD), but the data in pediatrics are limited. We describe the short-term effectiveness and safety of vedolizumab in a European multi-center pediatric IBD cohort. Method: Retrospective review of children (2-18 years) treated with vedolizumab from 19 centers affiliated with the Paediatric IBD Porto group of ESPGHAN. Primary outcome was week 14 corticosteroid-free remission (CFR)...
June 9, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28602178/differential-effects-of-the-glasgow-coma-scale-score-and-its-components-an-analysis-of-54-069-patients-with-traumatic-brain-injury
#8
Florence C M Reith, Hester F Lingsma, Belinda J Gabbe, Fiona E Lecky, Ian Roberts, Andrew I R Maas
INTRODUCTION: The Glasgow Coma Scale (GCS) is widely used in the assessment of clinical severity and prediction of outcome after traumatic brain injury (TBI). The sum score is frequently applied, but the differential influence of the components infrequently addressed. We aimed to investigate the contribution of the GCS components to the sum score, floor and ceiling effects of the components, and their prognostic effects. METHODS: Data on adult TBI patients were gathered from three data repositories: TARN (n=50,064), VSTR (n=14,062), and CRASH (n=9,941)...
June 1, 2017: Injury
https://www.readbyqxmd.com/read/28600102/physiologic-mechanism-of-discordance-between-instantaneous-wave-free-ratio-and-fractional-flow-reserve-insight-from-13-n-ammonium-positron-emission-tomography
#9
Joo Myung Lee, Doyeon Hwang, Jonghanne Park, Yaliang Tong, Bon-Kwon Koo
BACKGROUND: Invasive physiologic indices, such as fractional flow reserve (FFR) or instantaneous wave-free ratio (iFR), are used in clinical practice. We sought to evaluate the physiological mechanism of discordance between iFR and FFR using (13)N-ammonia positron emission tomography (PET)-derived quantitative parameters. METHODS: Data from 113 patients, who underwent both (13)N-ammonia PET and invasive FFR and iFR measurement, were analyzed. Coronary circulatory indices, such as myocardial blood flow (MBF), coronary flow reserve (CFR), microvascular resistance, and trans-stenosis resistance were compared between patients with discordant results (low FFR despite high iFR) and those with concordant abnormal results (low FFR and low iFR), using cut-off values of FFR≤0...
June 2, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28595700/angiotensin-converting-enzyme-inhibition-early-after-heart-transplantation
#10
William F Fearon, Kozo Okada, Jon A Kobashigawa, Yuhei Kobayashi, Helen Luikart, Sean Sana, Tiffany Daun, Steven A Chmura, Seema Sinha, Garett Cohen, Yasuhiro Honda, Michael Pham, David B Lewis, Daniel Bernstein, Alan C Yeung, Hannah A Valantine, Kiran Khush
BACKGROUND: Cardiac allograft vasculopathy (CAV) remains a leading cause of mortality after heart transplantation (HT). Angiotensin-converting enzyme inhibitors (ACEIs) may retard the development of CAV but have not been well studied after HT. OBJECTIVES: This study tested the safety and efficacy of the ACEI ramipril on the development of CAV early after HT. METHODS: In this prospective, multicenter, randomized, double-blind, placebo-controlled trial, 96 HT recipients were randomized to undergo ramipril or placebo therapy...
June 13, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28593557/assessment-of-myocardial-blood-flow-and-coronary-flow-reserve-with-positron-emission-tomography-in-ischemic-heart-disease-current-state-and-future-directions
#11
REVIEW
Firas Al Badarin, Ahmed Aljizeeri, Fatimah Almasoudi, Mouaz H Al-Mallah
Positron emission tomography (PET) is a versatile imaging technology that allows assessment of myocardial perfusion, both at a spatially relative scale and also in absolute terms, thereby enabling noninvasive evaluation of myocardial blood flow (MBF) and coronary flow reserve (CFR). Assessment of MBF using FDA-approved PET isotopes, such as (82)Rb and (13)N-ammonia, has been well validated, and several software packages are currently available, thereby allowing for MBF evaluation to be incorporated into routine workflow in contemporary nuclear laboratories...
June 7, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28585669/effectiveness-of-traumatic-brain-injury-management-guideline-introduction-in-hungary
#12
Abayomi Sorinola, Andras Buki, Janos Sandor, Endre Czeiter
AIM: The aim of this study was to describe the impact of the Traumatic Brain Injury management guideline introduction in Hungary. MATERIAL AND METHODS: Hospital discharge records (HDR) including age, gender, codes of interventions applied, ICD codes of diagnosed disorders of patients admitted between 01/01/2004 and 31/12/2010 with diagnosis of intracranial injury (S06 by ICD10) from every inpatient institution in Hungary were collected from the database of National Health Insurance Fund (NHIF)...
April 27, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28585219/pet-ct-scanning-with-3d-acquisition-is-feasible-for-quantifying-myocardial-blood-flow-when-diagnosing-coronary-artery-disease
#13
Osamu Manabe, Masanao Naya, Tadao Aikawa, Masahiko Obara, Keiichi Magota, Markus Kroenke, Noriko Oyama-Manabe, Kenji Hirata, Daiki Shinyama, Chietsugu Katoh, Nagara Tamaki
BACKGROUND: The quantification of myocardial blood flow (MBF) and coronary flow reserve (CFR) are useful approaches for evaluating the functional severity of coronary artery disease (CAD). (15)O-water positron emission tomography (PET) is considered the gold standard method for MBF quantification. However, MBF measurements in (15)O-water PET with three-dimensional (3D) data acquisition, attenuation correction using computed tomography (CT), and time of flight have not been investigated in detail or validated...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28585034/myocardial-perfusion-imaging-in-women-for-the-evaluation-of-stable-ischemic-heart-disease-state-of-the-evidence-and-clinical-recommendations
#14
Viviany R Taqueti, Sharmila Dorbala, David Wolinsky, Brian Abbott, Gary V Heller, Timothy M Bateman, Jennifer H Mieres, Lawrence M Phillips, Nanette K Wenger, Leslee J Shaw
This document from the American Society of Nuclear Cardiology represents an updated consensus statement on the evidence base of stress myocardial perfusion imaging (MPI), emphasizing new developments in single-photon emission tomography (SPECT) and positron emission tomography (PET) in the clinical evaluation of women presenting with symptoms of stable ischemic heart disease (SIHD). The clinical evaluation of symptomatic women is challenging due to their varying clinical presentation, clinical risk factor burden, high degree of comorbidity, and increased risk of major ischemic heart disease events...
June 5, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28584149/different-resistance-mechanisms-for-cadazolid-and-linezolid-in-c-difficile-found-by-whole-genome-sequencing-analysis
#15
Patrick Caspers, Hans H Locher, Philippe Pfaff, Sarah Diggelmann, Georg Rueedi, Daniel Bur, Daniel Ritz
Cadazolid (CDZ) is a new antibiotic currently in clinical development for the treatment of Clostridium difficile infections. CDZ interferes with the bacterial protein synthesis machinery. The aim of the present study was to identify resistance mechanisms for CDZ and compare to linezolid (LZD) in C. difficile by whole genome sequencing (WGS) of strains generated by invitro passages and of LZD resistant clinical isolates. Clones of C. difficile 630 selected with CDZ during 46 passages had a maximally 4-fold increased CDZ MIC, while the LZD MIC of clones selected with LZD increased up to 16-fold...
June 5, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28577226/pet-measurements-of-myocardial-blood-flow-post-myocardial-infarction-relationship-to-invasive-and-cardiac-magnetic-resonance-studies-and-potential-clinical-applications
#16
Henry Gewirtz
This review focuses on clinical studies concerning assessment of coronary microvascular and conduit vessel function primarily in the context of acute and sub acute myocardial infarction (MI). The ability of quantitative PET measurements of myocardial blood flow (MBF) to delineate underlying pathophysiology and assist in clinical decision making in this setting is discussed. Likewise, considered are physiological metrics fractional flow reserve, coronary flow reserve, index of microvascular resistance (FFR, CFR, IMR) obtained from invasive studies performed in the cardiac catheterization laboratory, typically at the time of PCI for MI...
June 2, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28574240/medicare-program-advancing-care-coordination-through-episode-payment-models-epms-cardiac-rehabilitation-incentive-payment-model-and-changes-to-the-comprehensive-care-for-joint-replacement-model-cjr-delay-of-effective-date-final-rule-delay-of-effective-date
#17
(no author information available yet)
This final rule finalizes May 20, 2017 as the effective date of the final rule titled "Advancing Care Coordination Through Episode Payment Models (EPMs); Cardiac Rehabilitation Incentive Payment Model; and Changes to the Comprehensive Care for Joint Replacement Model (CJR)" originally published in the January 3, 2017 Federal Register. This final rule also finalizes a delay of the applicability date of the regulations at 42 CFR part 512 from July 1, 2017 to January 1, 2018 and delays the effective date of the specific CJR regulations listed in the DATES section from July 1, 2017 to January 1, 2018...
May 19, 2017: Federal Register
https://www.readbyqxmd.com/read/28561648/tissue-agnostic-drug-development
#18
Keith T Flaherty, Dung T Le, Steven Lemery
The U.S. Food and Drug Administration (FDA) has approved drugs to treat patients with tumor types based on a single anatomic site, such as renal cell carcinoma or melanoma, rather than on a biomarker alone. This standard approach is based on a number of factors, including heterogeneity of drug effects in different biomarker-positive tumor types. Additionally, drug development for some drugs was primarily directed toward a specific genomic abnormality in a specific tumor type (e.g., drugs for anaplastic lymphoma kinase [ALK] fusion-positive non-small cell lung cancer)...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28555129/identification-of-atypical-el-torv-cholerae-o1-ogawa-hosting-sxt-element-in-senegal-africa
#19
Bissoume Sambe-Ba, Mamadou H Diallo, Abdoulaye Seck, Abdoul A Wane, Guillaume Constantin de Magny, Cheikh S-B Boye, Ahmad I Sow, Amy Gassama-Sow
Vibrio cholerae O1 is the causative agent of cholera with classical and El Tor, two well-established biotypes. In last 20 years, hybrid strains of classical and El Tor and variant El Tor which carry classical ctxB have emerged worldwide. In 2004-2005, Senegal experienced major cholera epidemic with a number of cases totalling more than 31719 with approximately 458 fatal outcomes (CFR, 1.44%). In this retrospective study, fifty isolates out of a total of 403 V. cholerae biotype El Tor serovar Ogawa isolates from all areas in Senegal during the 2004-2005 cholera outbreak were randomly selected...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28542866/pharmacokinetic-pharmacodynamic-evaluation-of-marbofloxacin-as-a-single-injection-for-pasteurellaceae-respiratory-infections-in-cattle-using-population-pharmacokinetics-and-monte-carlo-simulations
#20
A Paulin, M Schneider, F Dron, F Woehrle
Population pharmacokinetic of marbofloxacin was investigated with 52 plasma concentration-time profiles obtained after intramuscular administration of Forcyl® in cattle. Animal's status, pre-ruminant, ruminant, or dairy cow, was retained as a relevant covariate for clearance. Monte Carlo simulations were performed using a stratification by status, and 1000 virtual disposition curves were generated in each bovine subpopulation for the recommended dosage regimen of 10 mg/kg as a single injection. The probability of target attainment (PTA) of pharmacokinetic/pharmacodynamic (PK/PD) ratios associated with clinical efficacy and prevention of resistance was determined in each simulated subpopulation...
May 19, 2017: Journal of Veterinary Pharmacology and Therapeutics
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