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https://www.readbyqxmd.com/read/29148240/what-can-intracoronary-pressure-measurements-tell-us-about-cfr-now-comes-pb-cfr
#1
EDITORIAL
Kenta Nakamura, Larry S Dean
Pressure-bound (pb) coronary flow reserve (CFR) is a novel estimation of CFR, calculated from easily obtained baseline and hyperemic pressure assessment Validation of pb-CFR in previously reported lesions showed accuracy of 84% to CFR with sensitivity of 96% and specificity of 60% FFR >0.75 and low pb-CFR in DEFER was associated with increased angina and complications compared to high pb-CFR and this risk was not modified by elective revascularization.
November 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29141743/prognostic-and-predictive-factors-of-ebola-virus-disease-outcome-in-elderly-people-during-the-2014-outbreak-in-guinea
#2
Mahamoud Sama Cherif, Shyam Prakash Dumre, Diénaba Kassé, Fatoumata Cherif, Facély Camara, Alpha Koné, Mandiou Diakité, Mohamed Cisse, Mamadou Pathé Diallo, Edouard Le Gall, Juntra Karbwang, Kenji Hirayama
Elderly people occupy a prominent position in African societies; however, their potential linkage to high case fatality rate (CFR) in Ebola virus disease (EVD) was often overlooked. We describe the predictive factors for EVD lethality in the elderly. A total of 2,004 adults and 309 elderly patients with confirmed EVD were included in the analysis. The median age (interquartile range) was 35 years (23-44) in adults and 65 years (60-70) in the elderly. The proportion of funeral participation was significantly higher in the elderly group than in the adult group...
October 30, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29140634/combustibility-determination-for-cotton-gin-dust-and-almond-huller-dust
#3
Sidney E Hughs, Phillip J Wakelyn
It has been documented that some dusts generated while processing agricultural products, such as grain and sugar, can constitute combustible dust hazards. After a catastrophic dust explosion in a sugar refinery in 2008, the Occupational Safety and Health Administration (OSHA) initiated action to develop a mandatory standard to comprehensively address the fire and explosion hazards of combustible dusts. Cotton fiber and related materials from cotton ginning, in loose form, can support smoldering combustion if ignited by an outside source...
April 26, 2017: Journal of Agricultural Safety and Health
https://www.readbyqxmd.com/read/29132919/clonal-replacement-and-expansion-among-invasive-meningococcal-isolates-of-serogroup-w-in-france
#4
Eva Hong, Anne-Sophie Barret, Aude Terrade, Mélanie Denizon, Denise Antona, Myriam Aouiti-Trabelsi, Ala-Eddine Deghmane, Isabelle Parent du Châtelet, Daniel Levy-Bruhl, Muhamed-Kheir Taha
Background Neisseria meningitidis group W (NmW) belonging to the clonal complex ST-11 (NmW/cc11) spread in Europe and in France in 2000 and declined thereafter. In France, invasive meningococcal disease (IMD) due to NmW increased again in 2012 and thereafter since 2015. Several sub-lineages of NmW/cc11 are circulating worldwide with successive epidemic waves. We aimed to describe recent epidemiological trends of NmW in France and to explore the microbiological and epidemiological characteristics associated with different NmW/cc11 sub-lineages...
November 10, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29132649/doppler-versus-thermodilution-derived-coronary-microvascular-resistance-to-predict-coronary-microvascular-dysfunction-in-patients-with-acute-myocardial-infarction-or-stable-angina-pectoris
#5
Rupert P Williams, Guus A de Waard, Kalpa De Silva, Matthew Lumley, Kaleab Asrress, Satpal Arri, Howard Ellis, Awais Mir, Brian Clapp, Amedeo Chiribiri, Sven Plein, Paul F Teunissen, Maurits R Hollander, Michael Marber, Simon Redwood, Niels van Royen, Divaka Perera
Coronary microvascular resistance is increasingly measured as a predictor of clinical outcomes, but there is no accepted gold-standard measurement. We compared the diagnostic accuracy of 2 invasive indices of microvascular resistance, Doppler-derived hyperemic microvascular resistance (hMR) and thermodilution-derived index of microcirculatory resistance (IMR), at predicting microvascular dysfunction. A total of 54 patients (61 ± 10 years) who underwent cardiac catheterization for stable coronary artery disease (n = 10) or acute myocardial infarction (n = 44) had simultaneous intracoronary pressure, Doppler flow velocity and thermodilution flow data acquired from 74 unobstructed vessels, at rest and during hyperemia...
October 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29125809/burden-of-hospitalized-childhood-community-acquired-pneumonia-a-retrospective-cross-sectional-study-in-vietnam-malaysia-indonesia-and-the-republic-of-korea
#6
Kah Kee Tan, Duc Anh Dang, Ki Hwan Kim, Cissy Kartasasmita, Hwang Min Kim, Xu-Hao Zhang, Fakrudeen Shafi, Ta-Wen Yu, Emilio Ledesma, Nadia Meyer
BACKGROUND: Few studies describe the community-acquired pneumonia (CAP) burden in children in Asia. We estimated the proportion of all CAP hospitalizations in children from nine hospitals across the Republic of Korea (high-income), Indonesia, Malaysia (middle-income), and Vietnam (low/middle-income). METHODS: Over a one or two-year period, children <5 years hospitalized with CAP were identified using ICD-10 discharge codes. Cases were matched to standardized definitions of suspected (S-CAP), confirmed (C-CAP), or bacterial CAP (B-CAP) used in a pneumococcal conjugate vaccine efficacy study (COMPAS)...
November 10, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29122128/carbon-fibre-reinforced-peek-radiolucent-intramedullary-nail-for-humeral-shaft-fracture-fixation-technical-features-and-a-pilot-clinical-study
#7
Niksa Kojic, Christoph Rangger, Celenk Özgün, Jakisa Lojpur, Jerome Mueller, Yoram Folman, Eyal Behrbalk, Bore Bakota
PURPOSE: This prospective pilot study investigated the safety and efficacy of a novel radiolucent intramedullary nail (IMN) made of Carbon-Fibre-Reinforced Polyaryl-Ether-Ether-Ketone (CFR-PEEK) for humeral shaft fracture fixation. STUDY DESIGN: A prospective, single-arm, four-centre study. PATIENTS AND METHODS: A total of 46 patients with 46 humeral fractures classified as 12 A-B were treated with a novel CFR-PEEK IMN and followed for 12 months...
November 2017: Injury
https://www.readbyqxmd.com/read/29118860/coronary-flow-reserve-is-impaired-in-patients-with-obstructive-sleep-apnea
#8
Serife Savas Bozbas, Serpil Eroglu, Berna Akinci Ozyurek, Fusun Oner Eyuboglu
STUDY OBJECTIVES: Obstructive sleep apnea (OSA) is common in adult populations. Accumulating data indicate that it is independently associated with a variety of cardiovascular diseases and has prognostic importance in affected cases. In this study, we aimed to evaluate coronary flow reserve (CFR) in patients with OSA and controls. METHODS: Sixty-one patients undergoing an overnight polysomnography were enrolled in this study. Patients with an apnea-hypopnea index (AHI) >5 were accepted as OSA group (n = 45) and those with an AHI <5 were taken as controls (n = 16)...
October 2017: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/29118655/the-burden-of-dengue-source-reduction-measures-and-serotype-patterns-in-myanmar-2011-to-2015-r2
#9
Pwint Mon Oo, Khin Thet Wai, Anthony D Harries, Hemant Deepak Shewade, Tin Oo, Aung Thi, Zaw Lin
Background: Myanmar is currently classified as a high burden dengue country in the Asian Pacific region. The Myanmar vector-borne diseases control (VBDC) program has collected data on dengue and source reduction measures since 1970, and there is a pressing need to collate, analyze, and interpret this information. The aim of this study was to describe the burden of hospital-based dengue disease, dengue control measures, and serotype patterns in Myanmar between 2011 and 2015. Methods: This was a cross-sectional study using annual records from the Dengue Fever/Dengue Hemorrhagic Fever Prevention and Control Project in Myanmar...
2017: Tropical Medicine and Health
https://www.readbyqxmd.com/read/29117326/infant-group-b-streptococcal-disease-incidence-and-serotypes-worldwide-systematic-review-and-meta-analyses
#10
Lola Madrid, Anna C Seale, Maya Kohli-Lynch, Karen M Edmond, Joy E Lawn, Paul T Heath, Shabir A Madhi, Carol J Baker, Linda Bartlett, Clare Cutland, Michael G Gravett, Margaret Ip, Kirsty Le Doare, Craig E Rubens, Samir K Saha, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Stephanie Schrag
Background: Group B Streptococcus (GBS) remains a leading cause of neonatal sepsis in high-income contexts, despite declines due to intrapartum antibiotic prophylaxis (IAP). Recent evidence suggests higher incidence in Africa, where IAP is rare. We investigated the global incidence of infant invasive GBS disease and the associated serotypes, updating previous estimates. Methods: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data regarding invasive GBS disease in infants aged 0-89 days...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29111969/resistance-mechanisms-of-linezolid-nonsusceptible-enterococci-in-korea-low-rate-of-23s-rrna-mutations-in-enterococcus-faecium
#11
Sae-Mi Lee, Hee Jae Huh, Dong Joon Song, Hyang Jin Shim, Kyung Sun Park, Cheol-In Kang, Chang-Seok Ki, Nam Yong Lee
PURPOSE: To investigate linezolid-resistance mechanisms in linezolid-nonsusceptible enterococci (LNSE) isolated from a tertiary hospital in Korea. METHODOLOGY: Enterococcal isolates exhibiting linezolid MICs ≥4 mg l(-1) that were isolated between December 2011 and May 2016 were investigated by PCR and sequencing for mutations in 23S rRNA or ribosomal proteins (L3, L4 and L22) and for the presence of cfr, cfr(B) and optrA genes.Results/Key findings. Among 135 LNSE (87 Enterococcus faecium and 48 Enterococcus faecalis isolates), 39...
November 7, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29107347/sex-differential-effects-of-diphtheria-tetanus-pertussis-vaccine-for-the-outcome-of-paediatric-admissions-a-hospital-based-observational-study-from-guinea-bissau
#12
Annemette Andersen, Morten Bjerregaard-Andersen, Amabelia Rodrigues, Paulo Umbasse, Ane Bærent Fisker
BACKGROUND: In spite of protection against the targeted infections, a large volume of observational data indicates that diphtheria-tetanus-pertussis (DTP) vaccine may have a negative impact on overall childhood mortality in low-income countries, especially in girls. METHODS: In an observational study using data from Bandim Health Project's continuous registration of all admissions to the paediatric ward at the National Hospital Simão Mendes in Bissau, we investigated whether DTP was associated with higher female than male in-hospital mortality (female/male case fatality ratio (F/M CFR)) and whether the CFR comparing DTP-vaccinated and DTP-unvaccinated children differed by sex...
October 26, 2017: Vaccine
https://www.readbyqxmd.com/read/29104061/post-weaning-social-isolation-of-rats-leads-to-long-term-disruption-of-the-gut-microbiota-immune-brain-axis
#13
Fionn Dunphy Doherty, Siobhain M O'Mahony, Veronica L Peterson, Orla O'Sullivan, Fiona Crispie, Paul D Cotter, Peter Wigmore, Madeleine V King, John F Cryan, Kevin C F Fone
Early-life stress is an established risk for the development of psychiatric disorders. Post-weaning isolation rearing of rats produces lasting developmental changes in behavior and brain function that may have translational pathophysiological relevance to alterations seen in schizophrenia, but the underlying mechanisms are unclear. Accumulating evidence supports the premise that gut microbiota influence brain development and function by affecting inflammatory mediators, the hypothalamic-pituitary-adrenal axis and neurotransmission, but there is little knowledge of whether the microbiota-gut-brain axis might contribute to the development of schizophrenia-related behaviors...
November 2, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29103695/distribution-of-optra-and-cfr-in-florfenicol-resistant-staphylococcus-sciuri-of-pig-origin
#14
Run Fan, Dexi Li, Andrea T Feßler, Congming Wu, Stefan Schwarz, Yang Wang
A novel transferable oxazolidinone-phenicol resistance gene, optrA, which confers resistance to linezolid, the next-generation oxazolidinone tedizolid, and also to chloramphenicol and florfenicol, has been identified in enterococcal and staphylococcal species. Here, we investigated the epidemiology of optrA in florfenicol-resistant Staphylococcus spp. isolates of pig origin, and characterized the genetic context of oxazolidinone resistance genes in 20 optrA-positive florfenicol- and methicillin-resistant S...
October 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29101082/the-emerging-problem-of-linezolid-resistant-enterococcus
#15
REVIEW
Ruru Bi, Tingting Qin, Wenting Fan, Ping Ma, Bing Gu
Enterococcus is a significant pathogen of numerous infections, particularly nosocomial infections, thus conferring a great challenge to clinicians. Linezolid (an oxazolidinone antibiotic) is an important therapeutic option for infections caused by Gram-positive bacterial pathogens, especially vancomycin-resistant Enterococcus (VRE). To characterize these infections with respect to epidemiological, microbiological and clinical scenarios, we make a systematic review of literature available on linezolid-resistant Enterococcus (LRE)...
October 31, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29096829/ldl-apheresis-improves-coronary-flow-reserve-on-the-left-anterior-descending-artery-in-patients-with-familial-hypercholesterolemia-and-chronic-ischemic-heart-disease
#16
Tiziana Sampietro, Francesco Sbrana, Emilio Maria Pasanisi, Federico Bigazzi, Christina Petersen, Michele Coceani, Beatrice Dal Pino, Andrea Ripoli, Mascia Pianelli, Roberta Luciani
BACKGROUND: LDL apheresis (LA) influences the microcirculation, endothelial function and cardiovascular homeostasis. The aim of our study was to analyze temporal variations of coronary flow reserve (CFR) on the left anterior descending artery, obtained during dipyridamole stress echocardiography (DSE), in patients with severe familial hypercholesterolemia on LA (LA group) or not (not LA group) and ischemic heart disease (IHD). METHODS: The LA group consisted in 10 patients (mean age 65 ± 7 years, male 70%) with Familial Hypercholesterolemia and chronic IHD on maximally tolerated lipid lowering therapy and chronic LA treatment (median 7 years, interquartile range 6-14 years)...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29092052/long-lasting-successful-dissemination-of-resistance-to-oxazolidinones-in-mdr-staphylococcus-epidermidis-clinical-isolates-in-a-tertiary-care-hospital-in-france
#17
Laurent Dortet, Philippe Glaser, Najiby Kassis-Chikhani, Delphine Girlich, Philippe Ichai, Marc Boudon, Didier Samuel, Elodie Creton, Dilek Imanci, Rémy Bonnin, Nicolas Fortineau, Thierry Naas
Objectives: Patient- and procedure-related changes in modern medicine have turned CoNS into one of the major nosocomial pathogens. Treatments of CoNS infections are challenging owing to the large proportion of MDR strains and oxazolidinones often remain the last active antimicrobial molecules. Here, we have investigated a long-lasting outbreak (2010-13) due to methicillin- and linezolid-resistant (LR) CoNS (n = 168), involving 72 carriers and 49 infected patients. Methods: Antimicrobial susceptibilities were tested by the disc diffusion method and MICs were determined by broth microdilution or Etest...
October 30, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29080386/the-apex-trial-effects-of-allopurinol-on-exercise-capacity-coronary-and-peripheral-endothelial-function-and-natriuretic-peptides-in-patients-with-cardiac-syndrome-x
#18
Tiong Keng Lim, Awson Noman, AnnaMaria J Choy, Faisel Khan, Allan D Struthers, Chim C Lang
The role of endothelial dysfunction and oxidative stress in the pathogenesis of cardiac syndrome X has recently been recognised. Allopurinol has previously been shown to improve endothelial dysfunction, reduce oxidative stress burden and improve myocardial efficiency. In this 'proof of concept' study, we investigated the effect of allopurinol on exercise capacity, coronary and peripheral endothelial function, and serum B-type natriuretic peptide (BNP: a marker of cardiac function and myocardial ischaemia) in patients with cardiac syndrome X...
October 28, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29069202/association-of-inflammation-and-endothelial-dysfunction-with-coronary-microvascular-resistance-in-patients-with-cardiac-syndrome-x
#19
Ming Long, Zhibin Huang, Xiaodong Zhuang, Zena Huang, Yue Guo, Xinxue Liao, Chufan Luo
BACKGROUND: Although a proportion of CSX patients have impaired brachial artery flow-mediated dilatation (FMD) in response to hyperemia, suggesting that endothelial dysfunction in these patients may be systemic and not just confined to the coronary circulation; the underlying mechanisms triggering endothelial dysfunction in these patients are still incompletely understood. OBJECTIVES: To assess the association of the index of Microcirculatory Resistance (IMR) with endothelial dysfunction and inflammation in patients with CSX...
October 19, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/29059019/evaluating-optical-hazards-from-plasma-arc-cutting
#20
Eric Glassford, Gregory Burr
The Health Hazard Evaluation Program of the National Institute for Occupational Safety and Health evaluated a steel building materials manufacturer. The employer requested the evaluation because of concerns about optical radiation hazards from a plasma arc cutting system and the need to clarify eye protection requirements for plasma operators, other employees, and visitors. The strength of the ultraviolet radiation, visible radiation (light), and infrared radiation generated by the plasma arc cutter was measured at various distances from the source and at different operating amperages...
October 23, 2017: Journal of Occupational and Environmental Hygiene
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