keyword
https://read.qxmd.com/read/38536627/fatal-intoxications-with-zopiclone-a-cause-for-concern
#1
JOURNAL ARTICLE
Lova Tralla, Sara Gustavsson, Carl Söderberg, Anna K Jönsson, Fredrik C Kugelberg
INTRODUCTION: Zopiclone, a controlled substance prescribed for insomnia, has become a common toxicological finding in forensic autopsy cases. This study investigated the role and extent of zopiclone use in fatal intoxications in Sweden. METHODS: All forensic autopsy cases positive for zopiclone in femoral blood during 2012-2020 were selected. Among these cases, fatalities caused by intoxication according to the cause of death certificates issued by the forensic pathologist were identified...
March 27, 2024: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://read.qxmd.com/read/38536509/mid-and-long-term-results-of-open-repair-for-chronic-type-b-aortic-dissection-in-endovascular-era
#2
JOURNAL ARTICLE
Akitoshi Takazawa, Toshihisa Asakura, Osamu Kinoshita, Hiroyuki Nakajima, Akihiro Yoshitake
Medical management is the standard treatment of chronic type B aortic dissection (CTBAD). However, the roles of open surgical repair (OSR) and thoracic endovascular repair (TEVAR) in patients with CTBAD remain controversial. Thus, this study aimed to assess and compare the mid- and long-term clinical outcomes of OSR via left thoracotomy with that of TEVAR for CTBAD. The data of 85 consecutive patients who underwent surgery for CTBAD from April 2007 to May 2021 were retrospectively reviewed. The patients were divided into two groups: Group G, which included patients who underwent OSR, and Group E, which included patients who underwent TEVAR...
March 27, 2024: Heart and Vessels
https://read.qxmd.com/read/38536431/enhancing-safety-in-tumescent-liposuction-managing-sedation-related-respiratory-issues-and-serious-complications-under-deep-sedation-with-the-propofol-ketamine-protocol
#3
JOURNAL ARTICLE
Eun Ju Kim, Hyunju Kim, Younchan Park
BACKGROUND: Over the past 4 years, aesthetic surgery, notably liposuction, has substantially increased. Tumescent liposuction, a popular technique, has two variants-true tumescent liposuction (TTL) and semi-tumescent liposuction. While TTL reduces risks, it has limitations. There is no literature reported on semi-tumescent liposuction under deep sedation using the propofol-ketamine protocol, which is proposed as a potentially safe alternative. METHODS: The retrospective analysis covered 8 years and included 3094 patients performed for tumescent liposuction under deep sedation, utilizing the propofol-ketamine protocol...
March 27, 2024: Aesthetic Plastic Surgery
https://read.qxmd.com/read/38535514/pediatric-lemierre-s-syndrome-a-comprehensive-literature-review
#4
REVIEW
Salvatore Lavalle, Edoardo Masiello, Salvatore Cocuzza, Piero Pavone, Alessandra Di Nora, Christian Calvo-Henriquez, Jerome Rene Lechien, Miguel Mayo Yanez, Andrea Praticò, Manuela Ceccarelli, Giannicola Iannella, Annalisa Pace, Federica Maria Parisi, Giuseppe Magliulo, Antonino Maniaci
BACKGROUND: Lemierre syndrome is a rare, potentially fatal complication of oropharyngeal infections characterized by septic thrombophlebitis of the internal jugular vein. It primarily affects healthy adolescents and young adults. Its incidence declined after the antibiotic era, but it may have resurged in recent decades, likely due to judicious antibiotic use and increasing bacterial resistance. Prompt diagnosis and treatment are imperative to prevent significant morbidity and mortality...
March 18, 2024: Pediatric Reports
https://read.qxmd.com/read/38533397/initiation-and-up-titration-of-guideline-directed-medical-therapy-for-patients-with-heart-failure-better-faster-stronger
#5
REVIEW
Edgar Francisco Carrizales-Sepúlveda, Alejandro Ordaz-Farías, José Arturo Vargas-Mendoza, Raymundo Vera-Pineda, Ramiro Flores-Ramírez
Treatment for heart failure has experienced a major revolution in recent years, and current evidence shows that a combination of four medications (angiotensin receptor-neprilysin inhibitors + β-blockers + mineralocorticoid receptor antagonists + sodium.glucose cotransporter 2 inhibitors) offer the greatest benefit to our patients with significant reductions in cardiovascular mortality, heart failure hospitalisations and all-cause mortality. Unfortunately, despite their proven benefits, the implementation of these therapies is still low...
2024: Cardiac Failure Review
https://read.qxmd.com/read/38533136/association-of-inflammatory-markers-with-disease-progression-and-the-severity-of-covid-19
#6
JOURNAL ARTICLE
Stuti V Patel, Jaya M Pathak, Radhay J Parikh, Karan J Pandya, Priyal B Kothari, Arushi Patel
Introduction In December 2019, there was a massive outbreak of viral pneumonia, which had a high case fatality rate. Genetic sequencing of the virus showed similarity with severe acute respiratory syndrome coronavirus (SARS-CoV). It was later named novel coronavirus 2019 while the disease it caused was given the nomenclature of COVID-19. This deadly pneumonia outbreak was declared a pandemic by the World Health Organization (WHO). Aim To derive the strength of the correlation between blood levels of various inflammatory markers with the severity of COVID-19 pneumonia in patients affected with novel coronavirus 2019...
February 2024: Curēus
https://read.qxmd.com/read/38532997/association-between-blood-culture-turnaround-time-and-clinical-prognosis-in-emergency-department-patients-with-community-acquired-bloodstream-infection-a-retrospective-study-based-on-electronic-medical-records
#7
JOURNAL ARTICLE
Po-Hsiang Hsu, Renin Chang, Chun-Hao Yin, Yao-Shen Chen, Jin-Shuen Chen
IMPORTANCE: Previous investigations have found that time to positive blood culture (TTP) is a prognostic factor for clinical outcomes. In fact, what the emergency physician sees from the medical information system is TAT (turnaround time) defined as time required to post a bacterial culture report. We propose a definition of blood culture TAT that more closely aligns with clinical considerations by measuring the time from starting specimen culture to the release of an official blood culture report...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532708/rapid-life-saving-response-to-anti-pd-1-in-a-solid-organ-transplant-recipient-with-metastatic-cutaneous-squamous-cell-carcinoma-a-case-report-and-review
#8
JOURNAL ARTICLE
John P Antonelli, Myiah Quach, Aparna Mahajan, Jennifer Pleva, Vincent T Ma
Anti-programmed cell death protein 1 (PD-1) therapy is considered effective in the treatment of metastatic or locally advanced cutaneous squamous cell carcinoma but the use of these agents in solid organ transplant recipients (SOTRs) is often taken with caution. While anti-tumor effects without graft rejection have been reported, studies have shown high rates of fatal graft rejection with immune checkpoint therapy. In this case report, we present an SOTR patient with life-threatening, acute hypoxic respiratory failure due to rapidly progressive metastatic cutaneous squamous cell carcinoma with lung and pleural involvement...
March 27, 2024: Journal of Immunotherapy
https://read.qxmd.com/read/38531095/treatment-outcome-in-patients-with-disseminated-cysticercosis-a-systematic-review-of-case-reports-and-case-series
#9
JOURNAL ARTICLE
Ravindra Kumar Garg, Imran Rizvi, Rajarshi Chakravarty, Hardeep Singh Malhotra, Neeraj Kumar
Disseminated cysticercosis is defined by multiple brain lesions and involvement of other body sites. Cysticidal treatment in disseminated cysticercosis is considered life-threatening. We conducted a systematic review of all published cases and case series to assess the safety and efficacy of cysticidal treatment. We conducted a systematic review in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (PROSPERO CRD42022331895) to assess the safety and efficacy of cysticidal treatment...
March 26, 2024: American Journal of Tropical Medicine and Hygiene
https://read.qxmd.com/read/38528593/a-novel-large-intragenic-dpyd-deletion-causing-dihydropyrimidine-dehydrogenase-deficiency-a-case-report
#10
JOURNAL ARTICLE
Anna Malekkou, Marios Tomazou, Gavriella Mavrikiou, Maria Dionysiou, Theodoros Georgiou, Ioannis Papaevripidou, Angelos Alexandrou, Carolina Sismani, Anthi Drousiotou, Olga Grafakou, Petros P Petrou
BACKGROUND: Dihydropyrimidine dehydrogenase (DPD), is the initial and rate-limiting enzyme in the catabolic pathway of pyrimidines. Deleterious variants in the DPYD gene cause DPD deficiency, a rare autosomal recessive disorder. The clinical spectrum of affected individuals is wide ranging from asymptomatic to severely affected patients presenting with intellectual disability, motor retardation, developmental delay and seizures. DPD is also important as the main enzyme in the catabolism of 5-fluorouracil (5-FU) which is extensively used as a chemotherapeutic agent...
March 25, 2024: BMC Medical Genomics
https://read.qxmd.com/read/38528471/evolution-of-covid-19-infection-in-punjab-trends-during-five-waves-of-infection-in-the-province-of-punjab
#11
JOURNAL ARTICLE
Hasnain Javed, Aasia Khaliq, Shaper Mirza, Rimsha Khan, Warda Fatima
BACKGROUND: Pakistan witnessed five waves of COVID-19 infections during the pandemic. Punjab, the largest province of Pakistan, remained the epicentre due to a high infection rate. Administrative data for five waves of the pandemic was analyzed to determine the rate of infections and the significance of pharmacological and non-pharmacological interventions on the severity and duration of infection. METHODOLOGY: COVID-19 data from March 2020 to May 2023 was obtained from the Provincial Public Health Reference Laboratory (PPHRL), Punjab AIDS Control Program, Lahore...
March 25, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38528015/the-characteristics-and-risk-factors-of-fatal-falls-among-adults-aged-60-and-above-in-southwest-china
#12
JOURNAL ARTICLE
Rui Deng, Benyan Li, Mingfang Qin, Xinyi Yu, Junli Sun, Feng Jiao, Yuan Huang
Falls constitute a leading cause of unintentional injury deaths among older adults. This study aimed to examine the comprehensive characteristics of fatal falls among older individuals in Yunnan Province, China, to highlight the challenges faced in elderly care. A total of 22,798 accidental fall-related deaths were extracted from China's National Disease Surveillance Points System aged 60 and above between 2015 and 2019. Quantitative and textual data were analyzed to assess the incidence rates of initiating factors, locations, symptoms, and overall survival (OS) outcomes after falling...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38525584/mortality-trends-during-the-first-three-waves-of-the-covid-19-pandemic-at-an-urban-district-hospital-in-south-africa-a-retrospective-comparative-analysis
#13
JOURNAL ARTICLE
O Hirachund, C Pennefather, M Naidoo
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is the virus responsible for the COVID-19 (C19) pandemic. South Africa (SA) experienced multiple periods of increased transmission. Tertiary, regional and central hospitals were overwhelmed, resulting in low acceptance rates. OBJECTIVES: To compare mortality trends of patients who died in hospital from SARS-CoV-2 infection during the first three waves of infection as defined by the National Institute of Communicable Diseases of South Africa...
February 13, 2024: South African Medical Journal
https://read.qxmd.com/read/38525341/a-proposed-analytical-approach-to-estimate-excess-daily-mortality-rates-in-ecuador
#14
JOURNAL ARTICLE
Raul Patricio Fernandez-Naranjo, Jorge Vasconez-Gonzalez, Juan S Izquierdo-Condoy, Samanta Landazuri, Diana Castillo, Esteban Ortiz-Prado
BACKGROUND: The COVID-19 pandemic has proved deadly all over the globe; however, one of the most lethal outbreaks occurred in Ecuador. AIMS: This study aims to highlight the pandemic's impact on the most affected countries worldwide in terms of excess deaths per capita and per day. METHODS: An ecological study of all-cause mortality recorded in Ecuador was performed. To calculate the excess deaths relative to the historical average for the same dates in 2017, 2018, and 2019, we developed a bootstrap method based on the central tendency measure of mean...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38524037/altered-mental-status-in-the-setting-of-thrombotic-thrombocytopenic-purpura-ttp-and-spontaneous-coronary-artery-dissection-scad-a-case-report-and-literature-review
#15
Esmirna Perez, Nehemias Guevara, Jordan Smith, Ricardo Velasquez
Altered mental status (AMS) is a common condition encountered in daily practice. Finding the cause is essential for treatment, but sometimes this may be challenging. Spontaneous coronary artery dissection (SCAD) is frequently underdiagnosed and is a potentially fatal cause of acute coronary syndrome. Clinical presentation depends on the extent of SCAD, ranging from unstable angina to sudden death. AMS has not been reported with this condition, but it may be possible in hypoperfusion states. Thrombotic thrombocytopenic purpura (TTP) is part of the microangiopathic hemolytic anemia (MAHA) spectrum, presenting with AMS as the cardinal symptom...
February 2024: Curēus
https://read.qxmd.com/read/38523964/unveiling-the-surge-a-comprehensive-analysis-of-e-scooter-related-injuries-at-an-urban-level-1-trauma-center-in-vilnius-lithuania-2018-2021
#16
JOURNAL ARTICLE
Kristupas A Suslavičius, Simonas Utkus, Valentinas Uvarovas, Tomas Sveikata, Sigitas Ryliškis
Background The surge in electric scooter (e-scooter) adoption in 2019 fueled by sharing platforms has raised safety concerns, leading to an increased incidence of e-scooter-related injuries. Despite regulatory efforts, there has been a notable rise in accidents, prompting a comprehensive investigation. This study conducted at the Republican Vilnius University Hospital (RVUH), a level 1 trauma center, is one of the first in the Baltic States aiming to analyze the causes, severity, and frequency of e-scooter injuries from 2018 to 2021...
February 2024: Curēus
https://read.qxmd.com/read/38523536/the-relationship-between-statin-intake-and-risk-of-pancreatic-cancer-a-systematic-review-and-meta-analysis
#17
Hesamaldin Bagheri, Omid-Ali Adeli, Saeid Heidari-Soureshjani, Zahra Azadegan-Dehkordi, Catherine Mt Sherwin
BACKGROUND: Pancreatic neoplasm is one of the types of cancer with a high incidence and case-fatality rate. OBJECTIVES: This study was designed to investigate the relationship between statin intake and the risk of pancreatic cancer with a systematic review and meta-analysis approach. METHODS: This study was a systematic review and meta-analysis of studies published before 2023 in Cochrane Library, Web of Science (WOS), PubMed, Google Scholar, ScienceDirect, Scopus, and Embase databases...
March 20, 2024: Current Drug Research Reviews
https://read.qxmd.com/read/38521839/tuberculosis-case-fatality-is-higher-in-male-than-female-patients-in-europe-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Stephanie Pape, Sudip Jung Karki, Torben Heinsohn, Iris Brandes, Marie-Luise Dierks, Berit Lange
PURPOSE: Epidemiological TB data indicate differences in infection prevalence, progression rates, and clinical disease incidence between sexes. In contrast, evidence on sex-specific differential (post) TB case fatality in Europe has not been synthesized systematically. METHODS: We searched electronic databases and grey literature up to December 2020 for studies reporting sex-stratified TB death data for Europe. The JBI critical appraisal tools served for bias risk assessment and subgroup analyses for studying heterogeneity...
March 23, 2024: Infection
https://read.qxmd.com/read/38520890/massive-intracerebral-hemorrhage-following-methamphetamine-poisoning-in-a-man-a-case-report
#19
Elham Sadat Banimostafavi, Amirmasoud Taheri, Abdollah Malakian, Zakaria Zakariaei
INTRODUCTION AND IMPORTANCE: Methamphetamine (MAP) is a highly addictive stimulant known to have detrimental effects on the brain and various physiological systems, including an elevation in heart rate and blood pressure. Additionally, MAP use has been linked to the development of intracerebral hemorrhage (ICH), a serious and potentially fatal condition that is notably prevalent among young individuals. CASE PRESENTATION: We present the case of a 42-year-old man who suffered a massive ICH due to hypertension resulting from MAP poisoning...
March 14, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38517573/a-decade-of-neonatal-sepsis-in-stockholm-sweden-gram-positive-pathogens-were-four-times-as-common-as-gram-negatives
#20
JOURNAL ARTICLE
Frida Oldendorff, Viveka Nordberg, Christian G Giske, Lars Navér
PURPOSE: To assess Gram-positive bacterial (GPB) bloodstream infection (BSI) in neonates, covering incidence, morbidity, mortality, antimicrobial resistance patterns and biomarkers in Region Stockholm, Sweden between 2006 and 2016. METHODS: A population-based retrospective epidemiological study including infants with GPB-BSI, admitted to the neonatal units at Karolinska University Hospital (KUH). Data were collected from patient records, the Swedish Neonatal Quality Register, the microbiological laboratory at KUH and the Swedish Public Health Agency...
March 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
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