Antonio Maria D'Onofrio, Daniele Antonio Pizzuto, Rana Batir, Elisabetta Perrone, Fabrizio Cocciolillo, Federica Cavallo, Georgios Demetrios Kotzalidis, Alessio Simonetti, Giacomo d'Andrea, Mauro Pettorruso, Gabriele Sani, Daniela Di Giuda, Giovanni Camardese
INTRODUCTION: Dopaminergic transmission impairment has been identified as one of the main neurobiological correlates of both depression and clinical symptoms commonly associated with its spectrum such as anhedonia and psychomotor retardation. OBJECTIVES: We examined the relationship between dopaminergic deficit in the striatum, as measured by 123 I-FP-CIT SPECT imaging, and specific psychopathological dimensions in patients with major depressive disorder. METHODS: To our knowledge this is the first study with a sample of >120 subjects...
April 16, 2024: Journal of Affective Disorders