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Recurrent pregnancy loss

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https://www.readbyqxmd.com/read/29675486/granulocyte-colony-stimulating-factor-gene-rs1042658-variant-and-susceptibility-to-idiopathic-recurrent-pregnancy-loss-a-case-control-study
#1
Mahboobeh Nasiri, Kobra Jahangirizadeh
Background: Granulocyte colony-in stimulating factor ( G-CSF ) gene can be a potential candidate gene implicated recurrent pregnancy loss (RPL), a common complication of pregnancy with the prevalence of 1-5% among women of reproductive age. Objective: To investigate the association between rs1042658 polymorphism in the 3' untranslated region (3'UTR) of G-CSF gene and the risk of unexplained RPL among Iranian women. Materials and Methods: In total, 122 women with unexplained RPL and 140 healthy postmenopausal women as a control group were enrolled in this case-control study...
January 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29673671/a-case-control-study-to-compare-the-outcome-of-women-treated-by-two-minimally-invasive-procedures-ultraminilaparotomy-myomectomy-and-laparoscopic-myomectomy
#2
Kuo-Chang Wen, Pi-Lin Sung, Wen-Hsun Chang, Huann-Cheng Horng, Yi-Jen Chen, Wen-Ling Lee, Peng-Hui Wang
OBJECTIVE: Ultraminilaparotomy myomectomy (UMLT-M with less 4 cm transverse skin incision) and conventional 3-port wound laparoscopic myomectomy (LM) approaches were proposed as alternative minimally invasive procedures in the management of women with symptomatic uterine myomas but few studies have compared the outcomes of both procedures. MATERIALS AND METHODS: Between January 2002 and December 2003, 71 patients undergoing UMLT-M were compared with those 71 women undergoing LM...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29668899/how-uterine-microbiota-might-be-responsible-for-a-receptive-fertile-endometrium
#3
Marilen Benner, Gerben Ferwerda, Irma Joosten, Renate G van der Molen
BACKGROUND: Fertility depends on a receptive state of the endometrium, influenced by hormonal and anatomical adaptations, as well as the immune system. Local and systemic immunity is greatly influenced by microbiota. Recent discoveries of 16S rRNA in the endometrium and the ability to detect low-biomass microbiota fueled the notion that the uterus may be indeed a non-sterile compartment. To date, the concept of the 'sterile womb' focuses on in utero effects of microbiota on offspring and neonatal immunity...
April 16, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29665864/recurrent-pregnancy-loss-is-associated-to-leaky-gut-a-novel-pathogenic-model-of-endometrium-inflammation
#4
C Tersigni, S D'Ippolito, F Di Nicuolo, R Marana, V Valenza, V Masciullo, F Scaldaferri, F Malatacca, C de Waure, A Gasbarrini, G Scambia, N Di Simone
BACKGROUND: Recurrent pregnancy loss (RPL) occurs in 3-5% in about 30% of cases no cause can be found. Women with RPL show higher prevalence of undiagnosed gut disorders. Furthermore, in endometrial tissues of RPL women, higher expression of pro-inflammatory cytokines and Nalp-3 inflammasome has been observed. Aim of this study was to investigate whether an abnormal gut permeability might occur in RPL women and allow passage into systemic circulation of pro-inflammatory molecules able to induce endometrial inflammation...
April 17, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29665207/recombinant-factor-xiii-a-in-a-patient-with-factor-xiii-deficiency-and-recurrent-pregnancy-loss
#5
M Al-Khabori, A Pathare, M Menegatti, F Peyvandi
Inherited factor XIII deficiency is a very rare bleeding disorder and is one of the causes of recurrent pregnancy loss. The use of plasma derived factor XIII to improve pregnancy outcomes has been reported. We report a 26-year-old lady with factor XIII-A subunit deficiency who was treated with recombinant factor XIII-A and had a successful pregnancy outcome with no pregnancy related complications. Our case illustrates that the dose of recombinant factor XIII-A can be minimized and adjusted using frequent trough level monitoring...
April 17, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29663566/mir-27a-3p-and-mir-124-3p-upregulated-in-endometrium-and-serum-from-women-affected-by-chronic-endometritis-are-new-potential-molecular-markers-of-endometrial-receptivity
#6
Cinzia Di Pietro, Salvatore Caruso, Rosalia Battaglia, Marco Iraci Sareri, Alessandro La Ferlita, Fabrizio Strino, Gabriele Bonaventura, Maurizio Di Mauro, Maria Luisa Barcellona, Vincenzo Perciavalle, Michele Purrello, Antonio Cianci
PROBLEM: Chronic endometritis (CE) is usually asymptomatic and different studies demonstrated the relation with infertility and recurrent pregnancy loss. Altered regulation of protein-encoding genes in CE has been demonstrated, but no evidence about the involvement of microRNAs in the pathology is present in literature. METHOD OF STUDY: In the endometrium from 15 women with CE and 15 healthy women, by RT-qPCR single assays, we investigated some microRNAs targeting IL11, CCL4, IGF1, and IGFBP1, which mRNAs had been found differentially expressed in endometrium of women affected by CE...
April 16, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29662277/the-importance-of-cytogenetics-and-associated-molecular-techniques-in-the-management-of-patients-carrying-robertsonian-translocation-and-their-pregnancy-outcome-by-intracytoplasmic-sperm-injection
#7
Bibhas Kar, Subbiah Sivamani, Shankar Kundavi, Thankam Rama Varma
Objective: The present study outlines three cases of a Robertsonian translocation and the consequences for the initiation of pregnancy by intracytoplasmic sperm injection (ICSI). Three case histories are presented documenting structural chromosome abnormalities in infertile males. Materials and Methods: Semen analysis was performed according to the World Health Organization guidelines. Chromosome analysis was performed using G-banding. Y chromosome microdeletions were detected by multiplex polymerase chain reaction assays...
April 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29658346/association-between-thrombophilia-gene-polymorphisms-and-recurrent-pregnancy-loss-risk-in-the-iranian-population
#8
Razieh Bigdeli, Mohammad Reza Younesi, Erfan Panahnejad, Vahid Asgary, Samaneh Heidarzadeh, Hoda Mazaheri, Samira Louni Aligoudarzi
Miscarriage is the most common complication in pregnancy. Considering the importance of the problem thrombophilia in pregnant women and its association with recurrent pregnancy loss (RPL), analysis of polymorphisms of genes involved in thrombophilia can be useful. We investigated the frequency and association between ten polymorphisms of seven thrombophilia genes and RPL in an Iranian population. This case-control study was conducted on 200 women with recurrent pregnancy loss and also on 200 women with at least one successful pregnancy as the control group...
April 15, 2018: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/29651937/an-emerging-role-of-endometrial-inflammasome-in-reproduction-new-therapeutic-approaches
#9
Fiorella Di Nicuolo, Monia Specchia, Lorenza Trentavizi, Giovanni Scambia, Nicoletta Di Simone
One of the common complications of pregnancy is spontaneous pregnancy loss which occurs in an estimated 5- 15% of pregnancies. Of all women 1%-5% suffer from recurrent pregnancy loss (RPL). Despite the fact that RPL has been associated to various anatomic, hormonal, immune, hematologic, and genetic defects, in 30% of the patients, screening tests included in the RPL workup may have negative results. Recently, we demonstrated a significant increased activation of endometrial NALP-3 inflammasome, and a caspase-1 dependent secretion of IL-18 and IL-1β in the endometrial tissues obtained from RPL women compared with a fertile women group...
April 12, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29651447/impaired-gal-9-dysregulates-the-pbmc-induced-th1-th2-imbalance-in-abortion-prone-matings
#10
Mengzhou He, Ming Jiang, Yuan Zhou, Fanfan Li, Meitao Yang, Yao Fan, Yin Xie, Rajluxmee Beejadhursing, Ling Feng, Dongrui Deng
Recurrent miscarriage is defined as the loss of 3 or more consecutive pregnancies; however, the underlying immunologic mechanisms that trigger pregnancy loss remain largely unelucidated. Galectin-9 (Gal-9) may modulate a variety of biologic functions and play an important role in Th1/Th2 immune deviation. To analyze the mechanism of Gal-9 in abortion, we used the classical abortion-prone mouse model (DBA/2-mated CBA/J mice) to detect the expression of Gal-9 at the maternal-fetal interface. We also mimicked the immune environment of pregnancy by culturing trophoblast cells with peripheral blood mononuclear cells (PBMCs) to explore how Gal-9 might be involved in the pathogenesis of abortion...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29627847/pregnancy-outcomes-and-superiorities-of-prophylactic-cervical-cerclage-and-therapeutic-cervical-cerclage-in-cervical-insufficiency-pregnant-women
#11
Yanyan Liu, Zikan Ke, Wanmin Liao, Hanping Chen, Shiqing Wei, Xiaoquan Lai, Xi Chen
PURPOSE: To compare the clinical effect of prophylactic cervical cerclage and therapeutic cervical cerclage on pregnancy outcome and operative factors in cervical insufficiency pregnant women. METHODS: A retrospective study was conducted between June 2014 and September 2016 in a maternity ward, which included women who have had a single pregnancy and have been carried out a McDonald cerclage. All maternal medical records were reviewed. The efficacy of cerclage for preventing late foetal loss was assessed using multivariable logistic regression analysis...
April 7, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29627226/does-preimplantation-genetic-diagnosis-improve-reproductive-outcome-in-couples-with-recurrent-pregnancy-loss-owing-to-structural-chromosomal-rearrangement-a-systematic-review
#12
REVIEW
Mahmoud Iews, Justin Tan, Omur Taskin, Sukainah Alfaraj, Faten F AbdelHafez, Ahmed H Abdellah, Mohamed A Bedaiwy
Recurrent pregnancy loss (RPL) is a common, yet elusive, complication of pregnancy. Among couples at high risk of RPL, such as those carrying a structural chromosomal rearrangement, preimplantation genetic diagnosis (PGD) has been proposed as a tool to improve live birth rates and reduce the incidence of miscarriage; however, no clear consensus has been reached on its benefits in this population. This systematic review summarizes existing published research on the effect of PGD on pregnancy outcomes among carriers of chromosomal abnormalities with RPL...
March 15, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29626976/chronic-histiocytic-intervillositis-clinical-biochemical-and-radiological-findings-an-observational-study
#13
Lawrence Koby, Sarah Keating, Ann Kinga Malinowski, Rohan D'Souza
INTRODUCTION: Chronic histiocytic intervillositis (CHI) of the placenta although rare, has a high recurrence rate, is associated with serious adverse pregnancy outcomes and has no available treatment. This study aims to determine clinical, biochemical and radiological factors associated with CHI, to guide management of subsequent pregnancies. METHODS: This retrospective observational study included consecutive cases with a histopathologic diagnosis of CHI after 18 weeks of gestation, between 2001 and 2014, and no controls...
April 2018: Placenta
https://www.readbyqxmd.com/read/29622028/association-of-parental-methylenetetrahydrofolate-reductase-mthfr-c677t-gene-polymorphism-in-couples-with-unexplained-recurrent-pregnancy-loss
#14
Anil Kumar Sah, Nisha Shrestha, Pratikshya Joshi, Renu Lakha, Sweta Shrestha, Laxmi Sharma, Avinash Chandra, Neetu Singh, Yuvraj Kc, Bhola Rijal
OBJECTIVE: The aim of this study was to identify the association of parental MTHFR C677T gene polymorphism in couples with and without RPL history. RESULTS: During the study, 21.4% (15/70) of Ala222Val polymorphism was observed among RPL couples while no polymorphism was seen among normal, healthy couples. Our study did not find any association between MTHFR C677T polymorphism and gender (p > 0.05), gestational period (p > 0.05), geographical region (p > 0...
April 5, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29620217/effect-and-mechanism-of-the-a%C3%AE-2%C3%A2-gp-i-rh%C3%AE-2%C3%A2-gp-i-complex-on-jeg%C3%A2-3-cell-proliferation-migration-and-invasion
#15
Xiumin Lu, Lei Ren, Wenjing Zhang, Yanhong Liu
Antiphospholipid antibody (aPL)‑mediated antiphospholipid syndrome (APS) is an autoimmune disease. Upon binding to aPL, the primary antigen of aPL, β2‑glycoprotein I (β2‑GP I), induces abnormal immune function, which further activates downstream signaling pathways in the cell and eventually leads to APS. The present study aimed to determine whether β2‑GP I antigen and anti‑β2‑glycoprotein I antibody (aβ2‑GP I), which belong to the aPL class of antibodies, may affect human chorionic epithelium cell (JEG‑3) proliferation, migration and invasion...
March 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29619224/sperm-aneuploidy-and-dna-fragmentation-in-unexplained-recurrent-pregnancy-loss-a-multicenter-case-control-study
#16
Camille Esquerré-Lamare, Marie Walschaerts, Lucie Chansel Debordeaux, Jessika Moreau, Florence Bretelle, François Isus, Gilles Karsenty, Laetitia Monteil, Jeanne Perrin, Aline Papaxanthos-Roche, Louis Bujan
Background: Recurrent pregnancy loss (RPL) is defined as the loss of at least three pregnancies in the first trimester. Although the most common cause is embryo aneuploidy, and despite female checkup and couple karyotyping, in about 50% of cases RPL remain unexplained. Male implication has little been investigated and results are discordant. In this context, we conducted a multi-center prospective case-control study to investigate male gamete implication in unexplained RPL. Methods: A total of 33 cases and 27 controls were included from three university hospitals...
2018: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/29603821/lymphocytes-immunotherapy-for-preserving-pregnancy-mechanisms-and-challenges
#17
REVIEW
Hamed Hajipour, Hamid Reza Nejabati, Zeinab Latifi, Kobra Hamdi, Zahra Bahrami-Asl, Amir Fattahi, Mohammad Nouri
Due to the expression of paternal antigens by the embryo, pregnancy is considered as a semi-allograft and so immunological dysregulation is considered as one of the important causes in repeated implantation failure (RIF) and recurrent pregnancy loss (RPL). It has been revealed that lymphocytes immunotherapy (LIT) could be an appropriate approach to prevent pregnancy loss in such patients. Various mechanisms have been suggested for effectiveness of LIT such as enhancing expression of anti-paternal cytotoxic antibodies (APCA), progesterone-induced blocking factor (PIBF), anti-idiotypic antibodies (Ab2), and mixed lymphocyte reaction blocking antibodies (MLR-Bf), as well as reduction in the T helper 1/T helper 2 ratio and deviation in the pattern of cytokines production...
March 31, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29603135/treatment-efficacy-for-idiopathic-recurrent-pregnancy-loss-a-systematic-review-and-meta-analyses
#18
Emma Rasmark Roepke, Margareta Hellgren, Ragnhild Hjertberg, Lennart Blomqvist, Leif Matthiesen, Emir Henic, Sujata Lalitkumar, Annika Strandell
INTRODUCTION: Medical treatment of women with idiopathic recurrent pregnancy loss is controversial. The objective was to assess the effects of different treatments on live birth rates and complications in women with unexplained recurrent pregnancy loss. MATERIAL AND METHODS: We searched Medline, Embase, the Cochrane Library and identified 1415 publications. This systematic review included 21 randomized controlled trials regarding acetylsalicylic acid, low-molecular-weight heparin, progesterone, intravenous immunoglobulin or leukocyte immune therapy in women with ≥3 consecutive miscarriages of unknown cause...
March 30, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29602154/the-association-of-il-33-and-foxp3-gene-polymorphisms-with-recurrent-pregnancy-loss-in-egyptian-women
#19
Haidy E Zidan, Rehab S Abdul-Maksoud, Hala E Mowafy, Walid S H Elsayed
Deregulated immunity is one of the most important factors implicated in recurrent pregnancy loss (RPL). The possible role of interleukin-33 (IL-33) and forkhead/winged helix transcription factor (Foxp3) in RPL have not been fully investigated. We aimed to evaluate IL-33 rs1929992 and Foxp3 rs2232365 single nucleotide polymorphisms (SNPs) and their serum levels in Egyptian RPL females. Blood samples were collected from 142 RPL patients and 123 women as healthy controls. IL-33 rs1929992 SNP was determined by polymerase chain reaction restriction fragment length polymorphism and Foxp3 rs2232365 SNP was determined using allele specific polymerase chain reaction...
March 27, 2018: Cytokine
https://www.readbyqxmd.com/read/29565684/progestogens-and-pregnancy-loss
#20
H J A Carp
Progestational agents are often prescribed to prevent pregnancy loss. Progestogens affect implantation, cytokine balance, natural killer cell activity, arachidonic acid release and myometrial contractility. Progestogens have therefore been used at all stages of pregnancy including luteal-phase support prior to pregnancy, threatened miscarriage, recurrent miscarriage, and to prevent preterm labor. In luteal support, a Cochrane review reported that progestogens were associated with a higher rate of live births or ongoing pregnancy in the progesterone group (odds ratio 1...
March 22, 2018: Climacteric: the Journal of the International Menopause Society
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