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Recurrent pregnancy loss

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https://www.readbyqxmd.com/read/28622710/effect-of-intravenous-immunoglobulin-on-th1-and-th2-lymphocytes-and-improvement-of-pregnancy-outcome-in-recurrent-pregnancy-loss-rpl
#1
Majid Ahmadi, Samaneh Abdolmohammadi-Vahid, Mahnaz Ghaebi, Leili Aghebati-Maleki, Amir Afkham, Shahla Danaii, Sedigheh Abdollahi-Fard, Lida Heidari, Farhad Jadidi-Niaragh, Vahid Younesi, Mohammad Nouri, Mehdi Yousefi
BACKGROUND: Women with elevated natural killer (NK) cell frequency and function during pregnancy, suffer from recurrent pregnancy loss (RPL). In the present study, the possible effect of intravenous immunoglobulin (IVIG) administration on Th1 and Th2 cell frequency, cytokine secretion, and expression of transcription factors is compared between RPL patients and control group. MATERIALS AND METHODS: Totally, 44 women with a history of RPL (32 women as treated group and 12 as control group) were enrolled in the study...
June 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28621046/impact-of-borderline-subclinical-hypothyroidism-on-subsequent-pregnancy-outcome-in-women-with-unexplained-recurrent-pregnancy-loss
#2
Sayaka Uchida, Tetsuo Maruyama, Maki Kagami, Fumie Miki, Hanako Hihara, Satomi Katakura, Yushi Yoshimasa, Hirotaka Masuda, Hiroshi Uchida, Mamoru Tanaka
AIM: Because subclinical hypothyroidism (thyroid-stimulating hormone [TSH] > 4.5 IU/mL) is associated with adverse pregnancy outcome, including early pregnancy loss, TSH is recommended to be titrated to ≤2.5 mIU/L in levothyroxine-treated women before pregnancy. The purpose of this study was to determine whether borderline-subclinical hypothyroidism (borderline-SCH; 2.5 < TSH ≤ 4.5 IU/mL) affects the outcome of subsequent pregnancies in women with unexplained recurrent pregnancy loss (uRPL)...
June 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28620991/potential-positive-association-between-cytochrome-p450-1a1-gene-polymorphisms-and-recurrent-pregnancy-loss-a-meta-analysis
#3
Jie Li, Yang Chen, Sien Mo, Donghong Nai
In order to discover the potential genetic risks associated with recurrent pregnancy loss (RPL), this meta-analysis was conducted to assess the association between CYP1A1 gene polymorphism and RPL. Studies were retrieved from the databases PubMed, Embase, HuGENet, and CNKI. Four models were then applied. Seven studies, including three datasets for the rs1048943 and five for the rs4646903 single-nucleotide polymorphism (SNP), were included in this analysis, involving 613 cases and 398 controls for the rs1048943; and 864 cases and 842 controls for the rs4646903 SNP...
July 2017: Annals of Human Genetics
https://www.readbyqxmd.com/read/28618769/association-study-of-ctla-4-49a-g-gene-polymorphism-with-recurrent-pregnancy-loss-in-the-iranian-azeri-turkish-ethnic-group
#4
Mortaza Bonyadi, Sara Parsa, Simin Taghavi, Narges Zeinalzadeh
BACKGROUND/AIM: Recurrent pregnancy loss (RPL) is defined as two or more pregnancy losses. T-regulatory cells play an important role in the feto-maternal interface. Cytotoxic-T-lymphocyte antigen-4 (CTLA-4) is a molecule that downregulates the activation and proliferation of T cells. The objective of the current study was to investigate the possible association of CTLA-4+49A/G gene polymorphism with RPL among patients from the Iranian Azeri Turkish ethnic group. MATERIALS AND METHODS: The study group/patients consisted of 101 women with the experience of two or more pregnancy losses and the control group consisted of 101 women with at least two live births, without any previous history of pregnancy loss and autoimmune diseases from the same ethnic group...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28605668/association-of-endothelial-nitric-oxide-synthase-gene-variants-786-t-c-intron-4-b-a-vntr-and-894-g-t-with-idiopathic-recurrent-pregnancy-loss-a-case-control-study-with-haplotype-and-in-silico-analysis
#5
Alireza Azani, Asghar Hosseinzadeh, Roya Azadkhah, Ali Akbar Poursadegh Zonouzi, Ahmad Poursadegh Zonouzi, Younes Aftabi, Hourieh Khani, Leida Heidary, Shahla Danaii, Nasrin Bargahi, Nasser Pouladi, Sayed Mostafa Hosseini
OBJECTIVE(S): Many lines of evidence suggest that reduced production of nitric oxide (NO) due to single nucleotide polymorphisms in endothelial nitric oxide synthase (eNOS) gene may affect the implantation and maintenance of pregnancy. Accordingly, our objective was to investigate whether the eNOS polymorphisms (-786 T>C, intron 4 b/a VNTR and 894 G>T) and haplotypes may be associated with increased susceptibility to recurrent pregnancy loss (RPL). STUDY DESIGN: A total of 130 women with a history of two or more unexplained consecutive first trimester miscarriages and 110 ethnically matched women with at least two normal pregnancies and no history of pregnancy loss were included in the study as cases and controls, respectively...
May 30, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28603947/thrombophilic-gene-polymorphisms-and-recurrent-pregnancy-loss-in-greek-women
#6
M Chatzidimitriou, D Chatzidimitriou, M Mavridou, C Anetakis, F Chatzopoulou, T Lialiaris, S Mitka
INTRODUCTION: Recurrent pregnancy loss (RPL) is a multifactorial disorder. The aim of this study was the detection of various genetic polymorphisms and their correlation to RPL, in Greek women. METHODS: The impact of 12 thrombophilic polymorphisms was evaluated, among 48 Greek women with a history of RPL, vs 27 healthy parous women. Multiplex PCR and in situ hybridization on nitrocellulose films were performed, to investigate 12 genetic polymorphisms previously reported as risk factors for RPL...
June 12, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/28596666/enoxaparin-induced-skin-lesions-in-pregnancy-a-rare-but-clinically-recognizable-association
#7
Sumeet Prakash Mirgh, Abhay A Bhave
We report the case of a 29 year old pregnant female who experienced itching with erythematous plaques on prophylactic enoxaparin for recurrent fetal losses. These lesions generalized on rechallenge but erythema and itching gradually resolved after 4 weeks of discontinuation. Cutaneous adverse events with heparin have been reported (Villanueva et al. in Actas Dermosifiliogr 103:816-819, 2012; Neloska et al. in Acta Dermatovenerol Croat 23:223-224, 2015; Maldonado et al. in Clin Exp Dermatol 37:707-711, 2012; Schindewolf et al...
June 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28594768/detection-of-an-inherited-deletion-in-products-of-conception-in-a-patient-with-recurrent-losses-and-normal-karyotype
#8
Jeffrey Thorne, Alicia Craffey, John C Nulsen
BACKGROUND: Microarray analysis testing on products of conception can provide valuable information in the evaluation of recurrent pregnancy loss beyond ploidy status. CASE: A maternally inherited deletion on the X chromosome was detected by microarray analysis performed on products of conception in a couple with recurrent pregnancy loss. The mother had a previously demonstrated normal karyotype with standard cytogenetic analysis but was subsequently determined to have the same X chromosome deletion by oligonucleotide single-nucleotide polymorphism (SNP) microarray analysis...
June 6, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28593919/effects-of-interleukin-1-receptor-antagonist-il-1ra-gene-86-bp-vntr-polymorphism-on-recurrent-pregnancy-loss-a-case-control-study
#9
Yasamin Sayed Hajizadeh, Elina Emami, Marina Nottagh, Zahra Amini, Nazila Fathi Maroufi, Saba Haj Azimian, Alireza Isazadeh
Objective Recurrent pregnancy loss (RPL) is a heterogeneous disease which is defined as two or more consecutive fetal losses during early pregnancy. Interleukin-1 receptor antagonist (IL-1Ra) is a anti-inflammatory cytokine, which inhibits IL-1 activity by binding to its receptors. The aim of this study was to investigate the association between RPL and IL-1Ra intron 2 polymorphism (86 bp VNTR) in Iranian women. Materials and methods In this case control study, genetic polymorphism was studied in 140 RPL patients and 140 healthy women as controls...
May 26, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/28584200/efficacy-of-different-treatment-regimens-for-antiphospholipid-syndrome-related-recurrent-spontaneous-abortion
#10
Sheng-Long Ye, Xun-Ke Gu, Li-Yuan Tao, Ji-Mei Cong, Yong-Qing Wang
BACKGROUND: Antiphospholipid syndrome (APS)-related immune factors are considered as an important cause of recurrent spontaneous abortion (RSA). Anticoagulant and anti-inflammatory treatments are believed to effectively improve adverse pregnancy outcomes by affecting the abnormal autoimmune response of the maternal-fetal interface. The aim of this study was to observe the clinical characteristics and treatment outcomes of anticoagulant regimens and anti-inflammatory plus anticoagulation regimens for APS-related RSA...
June 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28553146/recurrent-pregnancy-loss-current-perspectives
#11
REVIEW
Hady El Hachem, Vincent Crepaux, Pascale May-Panloup, Philippe Descamps, Guillaume Legendre, Pierre-Emmanuel Bouet
Recurrent pregnancy loss is an important reproductive health issue, affecting 2%-5% of couples. Common established causes include uterine anomalies, antiphospholipid syndrome, hormonal and metabolic disorders, and cytogenetic abnormalities. Other etiologies have been proposed but are still considered controversial, such as chronic endometritis, inherited thrombophilias, luteal phase deficiency, and high sperm DNA fragmentation levels. Over the years, evidence-based treatments such as surgical correction of uterine anomalies or aspirin and heparin for antiphospholipid syndrome have improved the outcomes for couples with recurrent pregnancy loss...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28546661/management-of-reproductive-tract-anomalies
#12
Garima Kachhawa, Alka Kriplani
Reproductive tract malformations are rare in general population but are commonly encountered in women with infertility and recurrent pregnancy loss. Obstructive anomalies present around menarche causing extreme pain and adversely affecting the life of the young women. The clinical signs, symptoms and reproductive problems depend on the anatomic distortions, which may range from congenital absence of the vagina to complex defects in the lateral and vertical fusion of the Müllerian duct system. Identification of symptoms and timely diagnosis are an important key to the management of these defects...
June 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28526167/significance-of-body-weight-change-during-fertility-sparing-progestin-therapy-in-young-women-with-early-endometrial-cancer
#13
Jeong-Yeol Park, Seok Ju Seong, Tae-Jin Kim, Jae Weon Kim, Duk-Soo Bae, Joo-Hyun Nam
OBJECTIVE: To evaluate the influence of body weight change during fertility-sparing progestin therapy on oncologic and reproductive outcomes in young women with early-stage endometrial cancer who did not complete child bearing. METHODS: This multicenter, retrospective study included 154 young patients with well-differentiated, endometrium-confined endometrioid endometrial adenocarcinoma on magnetic resonance imaging who received fertility-sparing progestin therapy...
May 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28516786/association-of-angiogenic-cytokines-vegf-a-and-vegf-c-and-clinical-characteristic-in-women-with-unexplained-recurrent-miscarriage
#14
A Bagheri, P Kumar, A Kamath, P Rao
INTRODUCTION: Recurrent miscarriage (RM) defined as 2 or more spontaneous miscarriage before 20 weeks of gestation, affects at least 1 % of couples trying to conceive. In over 50 % of cases, the cause of the loss of pregnancy remains unexplained. Reduced expression of Angiogenic factors such as: vascular endothelial growth factor (VEGF-A) and VEGF-C has been linked with spontaneous miscarriage, likely due to defective foetal and placental angiogenesis. AIMS AND OBJECTIVES: To investigate the relationships between serum level of VEGF-A and VEGF-C with clinical characteristic in women with URM and compare to pregnant and healthy women...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28515823/lupus-negative-libman-sacks-endocarditis-complicated-by-catastrophic-antiphospholipid-syndrome
#15
Ghulam Murtaza, Joy Iskandar, Tara Humphrey, Sujeen Adhikari, Aneesh Kuruvilla
Libman-Sacks endocarditis is characterized by sterile and verrucous lesions that predominantly affect the aortic and mitral valves. In most cases, patients do not have significant valvular dysfunction. However, patients with significant valvular dysfunction may present with serious complications such as cardiac failure, arrhythmias, and thromboembolic events. Recently, association of Libman-Sacks endocarditis with antiphospholipid antibody syndrome (APS) has been made. APS is most commonly defined by venous and arterial thrombosis, recurrent pregnancy loss, and thrombocytopenia...
April 2017: Cardiology Research
https://www.readbyqxmd.com/read/28508879/oxidative-stress-and-male-infertility
#16
REVIEW
Shilpa Bisht, Muneeb Faiq, Madhuri Tolahunase, Rima Dada
DNA damage, largely owing to oxidative stress, is a leading cause of defective sperm function. High levels of oxidative stress result in damage to sperm DNA, RNA transcripts, and telomeres and, therefore might provide a common underlying aetiology of male infertility and recurrent pregnancy loss, in addition to congenital malformations, complex neuropsychiatric disorders, and childhood cancers in children fathered by men with defective sperm cells. Spermatozoa are highly vulnerable to oxidative stress owing to limited levels of antioxidant defence and a single, limited DNA-damage detection and repair mechanism...
May 16, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28508414/cervical-cerclage-placed-before-14%C3%A2-weeks-gestation-in-women-with-one-previous-midtrimester-loss-a-population-based-cohort-study
#17
Margaret E Harpham, Charles S Algert, Christine L Roberts, Jane B Ford, Antonia W Shand
BACKGROUND: Cervical cerclage is used in an attempt to reduce recurrence risk of preterm birth, but evidence for use is limited. AIMS: To compare pregnancy outcomes among women with a single previous midtrimester delivery when managed with or without a cervical cerclage. MATERIALS AND METHODS: Population-based cohort study of all women in New South Wales, Australia with a singleton pregnancy ending in birth/miscarriage ≥14 and <28 weeks, between 2003 and 2011...
May 16, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28504829/prediction-of-thrombophilia-in-patients-with-unexplained-recurrent-pregnancy-loss-using-a-statistical-model
#18
Tongfei Wang, Xiaomin Kang, Liying He, Zhilan Liu, Haijing Xu, Aimin Zhao
OBJECTIVE: To establish a statistical model to predict thrombophilia in patients with unexplained recurrent pregnancy loss (URPL). METHODS: A retrospective case-control study was conducted at Ren Ji Hospital, Shanghai, China, from March 2014 to October 2016. The levels of D-dimer (DD), fibrinogen degradation products (FDP), activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen (Fg), and platelet aggregation in response to arachidonic acid (AA) and adenosine diphosphate (ADP) were collected...
May 15, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28501364/immune-modulation-treatments-where-is%C3%A2-the-evidence
#19
REVIEW
Malene Meisner Hviid, Nick Macklon
While advances in assisted reproductive techniques have been substantial, failure of the apparently viable embryo to implant remains a source of distress and frustration to patients and specialists alike. The unique maternal immunological response to the embryo and the notion that defects in early placentation underlie the great complications of pregnancy have focused attention on the therapeutic potential of peri-implantation immunomodulation. On the face of it, the rationale for this approach is very attractive...
June 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28498240/simple-vaginal-trachelectomy-a-valuable-fertility-preserving-option-in-early-stage-cervical-cancer
#20
Marie Plante, Marie-Claude Renaud, Alexandra Sebastianelli, Jean Gregoire
OBJECTIVE: Radical trachelectomy is a valid alternative for the treatment of early-stage cervical cancer in young women who wish to preserve fertility potential. Recent data indicate that even less radical surgery could be performed in low-risk cases. The objective of our study was to evaluate the safety of simple vaginal trachelectomy and node assessment in patients with low-risk, early-stage cervical cancer (<2 cm). METHODS: From May 2007 to July 2016, 35 women underwent a simple vaginal trachelectomy with laparoscopic sentinel lymph node mapping + pelvic node dissection...
June 2017: International Journal of Gynecological Cancer
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