keyword
MENU ▼
Read by QxMD icon Read
search

Recurrent pregnancy loss

keyword
https://www.readbyqxmd.com/read/28103273/association-between-genetic-polymorphisms-in-interleukin-genes-and-recurrent-pregnancy-loss-a-systematic-review-and-meta-analysis
#1
Meixiang Zhang, Jiawei Xu, Xiao Bao, Wenbin Niu, Linlin Wang, Linqing Du, Nan Zhang, Yingpu Sun
Interleukins are a group of immunomodulatory proteins that mediate a variety of immune reactions in the human body. To investigate the association between interleukin gene polymorphisms and recurrent pregnancy loss (RPL), we reviewed 21 studies from MEDLINE, EMBASE, OVID SP and PubMed to evaluate RPL-related interleukin gene polymorphisms. Meta-analysis was performed on 12 of the polymorphisms, and a review included the others. Our integrated results indicated that IL-1β (-511C/T) (P = 0.02, 95% CI 0.77[0...
2017: PloS One
https://www.readbyqxmd.com/read/28099717/maternal-serum-amyloid-a-level-as-a-novel-marker-of-primary-unexplained-recurrent-early-pregnancy-loss
#2
Moustafa I Ibrahim, Ahmed R Ramy, Ahmed S Abdelhamid, Mohamed I Ellaithy, Amna Omar, Rany M Harara, Hayam Fathy, Ashraf S Abolouz
OBJECTIVE: To assess maternal serum amyloid A (SAA) levels among women with primary unexplained recurrent early pregnancy loss (REPL). METHODS: A prospective study was conducted among women with missed spontaneous abortion in the first trimester at Ain Shams University Maternity Hospital, Cairo, Egypt, between January 21 and December 25, 2014. Women with at least two consecutive primary unexplained REPLs and no previous live births were enrolled. A control group was formed of women with no history of REPL who had at least one previous uneventful pregnancy with no adverse outcomes...
December 7, 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28073874/successful-pregnancy-following-treatment-of-recurrent-chronic-histiocytic-intervillositis
#3
Leehe Vardi, Helen Paterson, Noelyn Anne Hung
Chronic histiocytic intervillositis (CHI) is a rare placental lesion associated with adverse obstetric outcomes and high recurrence rate. We report a case of six consecutive pregnancies in one woman, where CHI was detected following an intrauterine death in the fifth pregnancy, after being missed in four earlier losses. The successful sixth pregnancy was treated with a combination of immunosuppressive and antithrombotic agents. While low-molecular-weight heparin (LMWH) and aspirin had been shown to improve pregnancy outcome in recurrent pregnancy loss, there was limited evidence of improved outcome in CHI...
January 10, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28070710/the-accumulation-of-vitrified-oocytes-is-a-strategy-to-increase-the-number-of-euploid-available-blastocysts-for-transfer-after-preimplantation-genetic-testing
#4
Sandrine Chamayou, Maria Sicali, Carmelita Alecci, Carmen Ragolia, Annalisa Liprino, Daniela Nibali, Giorgia Storaci, Antonietta Cardea, Antonino Guglielmino
PURPOSE: In a preimplantation genetic diagnosis for aneuploidy (PGD-A) program, the more embryos available for biopsy, consequently increases the chances of obtaining euploid embryos to transfer. The aim was to increase the number of viable euploid blastocysts in patients undergoing PGD-A using fresh oocytes together with previously accumulated vitrified oocytes. METHODS: Sixty-nine patients with normal ovarian reserve underwent PGD-A for repeated implantation failure or recurrent pregnancy loss indication...
January 9, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28059935/a-determined-woman-anxiety-unresolved-mourning-and-capacity-assessment-in-recurrent-pregnancy-loss
#5
Osarumen Nicole Doghor, Florina Haimovici, Donna Mathias, Deborah Knudson-Gonzalez, Cathryn Freid
No abstract text is available yet for this article.
January 2017: Harvard Review of Psychiatry
https://www.readbyqxmd.com/read/28054230/tumor-necrosis-factor-alpha-and-pregnancy-focus-on-biologics-an-updated-and-comprehensive-review
#6
REVIEW
Jaume Alijotas-Reig, Enrique Esteve-Valverde, Raquel Ferrer-Oliveras, Elisa Llurba, Josep Maria Gris
Tumor necrosis factor-α (TNF-α) is a central regulator of inflammation, and TNF-α antagonists may be effective in treating inflammatory disorders in which TNF-α plays a major pathogenic role. TNF-α has also been associated with inflammatory mechanisms related to implantation, placentation, and pregnancy outcome. TNF-α is secreted by immune cells and works by binding to TNFR1 and TNFR2 cell receptors. TNF-α is also related to JAK/STAT pathways, which opens up hypothetical new targets for modifying. The accurate balance between Th1 cytokines, mainly TNF-α, Th17, and Th2, particularly IL-10 is essential to achieve good obstetric outcomes...
January 4, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28041830/luteal-phase-hcg-support-for-unexplained-recurrent-pregnancy-loss-a-low-hanging-fruit
#7
Chelsea Fox, Denise Azores-Gococo, Linda Swart, Kristin Holoch, Ricardo F Savaris, Creighton E Likes, Paul B Miller, David A Forstein, Bruce A Lessey
Recurrent pregnancy loss (RPL) is defined by two or more failed pregnancies and accounts for only 1-5% of pregnancy failures. Treatment options for unexplained RPL (uRPL) are limited. Previous studies suggest a link between delayed implantation and pregnancy loss. Based on this, a timely signal for rescue of the corpus luteum (CL) using human chorionic gonadotrophin (HCG) could improve outcomes in women with uRPL. This retrospective cohort study included 98 subjects with uRPL: 45 underwent 135 monitored cycles without HCG support; and 53 underwent 142 cycles with a single mid-luteal HCG injection...
December 21, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28028298/microrna-expression-in-antiphospholipid-syndrome-a-systematic-review-and-microrna-target-genes-analysis
#8
S Muhammad Shazwan, M Muhammad Aliff, A A Asral Wirda, A R Hayati, M Maizatul Azma, A R Nur Syahrina, A H Nazefah, S Jameela, M M Nur Fariha
INTRODUCTION: Antiphospholipid antibodies (aPL) are autoantibodies that attack phospholipid through anti-beta 2-glycoprotein 1. The actions of aPL are associated with events leading to thrombosis and morbidity in pregnancy. Antiphospholipid syndrome (APS) is diagnosed when a patient is persistently positive for aPL and also has recognised clinical manifestations such as recurrent pregnancy losses, arterial or venous thrombosis and in a catastrophic case, can result in death. Unfortunately, the pathogenesis of APS is still not well established...
December 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/28012790/the-role-of-parental-microrna-alleles-in-recurrent-pregnancy-loss-an-association-study
#9
Mona Amin-Beidokhti, Reza Mirfakhraie, Shohreh Zare-Karizi, Fatemeh Karamoddin
The medical evaluation of recurrent pregnancy loss (RPL), the occurrence of two or more consecutive pregnancy losses prior to 20th week of gestation, is mainly focused on maternal factors. However, paternally expressed genes may also play a role in implantation and placenta quality. This study aimed to investigate the possible association between parental miR-196a2C>T and miR-499aT>C polymorphisms and RPL in a case-control study including 200 RPL couples and 400 healthy men and women. Genotyping was performed using Tetra-ARMS-PCR and PCR-RFLP for miR-196a2C>T and miR-499aT>C polymorphisms, respectively...
December 13, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28011331/multi-drug-resistant-female-genital-tuberculosis-a-preliminary-report
#10
J B Sharma, Alka Kriplani, Eshani Sharma, Sangeeta Sharma, Sona Dharmendra, Sunesh Kumar, P Vanamail, S K Sharma
OBJECTIVE: Evaluation of 6 patients presenting with tubo-ovarian mass or infertility with multi drug resistant (MDR) female genital tuberculosis (FGTB). STUDY DESIGN: It was an observational study in a tertiary referral centre, India on subjects with MDR FGTB on clinical examination and investigations. All patients were given category IV drugs using kanamycin (intramuscular), levofloxacin, pyrazinamide, cycloserine, ethionamide and ethambutol (or para aminosalicylic acid [PAS] for ethambutol resistant cases) for 6 months intensive phase followed by oral levofloxacin, cycloserine, ethionamide and ethambutol (or PAS for ethambutol resistant cases) for 18 months continuation phase...
December 12, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28007693/pad4-deficiency-decreases-inflammation-and-susceptibility-to-pregnancy-loss-in-a-mouse-model
#11
Luise Erpenbeck, Chanchal Sur Chowdhury, Zsuzsanna K Zsengellér, Maureen Gallant, Suzanne D Burke, Stephen Cifuni, Sinuhe Hahn, Denisa D Wagner, S Ananth Karumanchi
Inflammation is thought to play a critical role in the pathogenesis of placentation disorders such as recurrent miscarriages, growth restriction, and preeclampsia. Recently, neutrophil extracellular traps (NETs) have emerged as a potential mechanism for promoting inflammation in both infectious and noninfectious disorders. To investigate a pathogenic role for NETs in placentation disorders, we studied a model of antiangiogenic factor-mediated pregnancy loss in wild-type (WT) mice and in mice deficient in peptidylarginine deiminase 4 (Padi4(-/-)) that are unable to form NETs...
December 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27958626/genetic-causes-of-recurrent-miscarriages
#12
Marta Kacprzak, Marta Chrzanowska, Beata Skoczylas, Hanna Moczulska, Maciej Borowiec, Piotr Sieroszewski
Recurrent miscarriage is an important problem in reproductive health, which affects 1-5% of couples. The aim of this article is to summarize current knowledge on the genetic causes of recurrent miscarriage. It presents the most common parental genetic disorders (karyotype abnormalities, recessive diseases carrier status, dominant diseases and thrombophilia) connected with recurrent pregnancy loss, as well as research into other possible genetic causes. This review also sets out to demonstrate changes in the embryonic/fetal genome that may lead to abortions, and discusses the methods used to assess miscarried material, together with their advantages and disadvantages...
2016: Ginekologia Polska
https://www.readbyqxmd.com/read/27929073/rna-sequencing-of-chorionic-villi-from-recurrent-pregnancy-loss-patients-reveals-impaired-function-of-basic-nuclear-and-cellular-machinery
#13
Siim Sõber, Kristiina Rull, Mario Reiman, Piret Ilisson, Pirkko Mattila, Maris Laan
Recurrent pregnancy loss (RPL) concerns ~3% of couples aiming at childbirth. In the current study, transcriptomes and miRNomes of 1(st) trimester placental chorionic villi were analysed for 2 RPL cases (≥6 miscarriages) and normal, but electively terminated pregnancies (ETP; n = 8). Sequencing was performed on Illumina HiSeq 2000 platform. Differential expression analyses detected 51 (27%) transcripts with increased and 138 (73%) with decreased expression in RPL compared to ETP (DESeq: FDR P < 0...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27920996/art-strategy-for-treatment-of-recurrent-pregnancy-loss-isn-t-it-better-to-forget
#14
EDITORIAL
Mohammad Reza Sadeghi
No abstract text is available yet for this article.
October 2016: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/27903074/bicornuate-uterus-is-an-independent-risk-factor-for-cervical-os-insufficiency-a-retrospective-population-based-cohort-study
#15
Salvatore Andrea Mastrolia, Yael Baumfeld, Reli Hershkovitz, Giuseppe Loverro, Edoardo Di Naro, David Yohai, Polina Schwarzman, Adi Yehuda Weintraub
INTRODUCTION: The purpose of our study was to explore maternal and fetal outcomes in the second and third trimester in women with bicornuate uterus. METHODS: A total of 280,106 pregnancies met the inclusion criteria and were divided in two study groups: (1) pregnancies in women with bicornuate uterus (n = 444); and (2) controls (n = 279,662). The diagnosis of bicornuate uterus was performed in all patients during the workup for infertility or recurrent pregnancy loss, during pregnancy, or at the time of cesarean delivery...
December 1, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27888033/prenatal-intake-of-vitamins-and-allergic-outcomes-in-the-offspring-a-systematic-review-and-meta-analysis
#16
Mariam Vahdaninia, Heather Mackenzie, Suzannah Helps, Taraneh Dean
BACKGROUND: Allergic diseases have seen a rise worldwide, with children suffering the highest burden. Thus, early prevention of allergic diseases is a public health priority. OBJECTIVE: To synthesize the evidence from randomized controlled trials (RCTs) assessing the effect of vitamin interventions during pregnancy on developing allergic diseases in offspring. METHODS: We searched CENTRAL, MEDLINE, SCOPUS, World Health Organization's International Clinical Trials Registration, E-theses, and Web of Science...
November 22, 2016: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/27883173/clinical-application-of-snp-array-analysis-in-first-trimester-pregnancy-loss-a-prospective-study
#17
Y Wang, Q Cheng, L Meng, C Luo, H Hu, J Zhang, J Cheng, T Xu, T Jiang, D Liang, P Hu, Z Xu
Chromosomal microarray analysis (CMA) has been used routinely in pediatric and prenatal genetic diagnosis in clinical practice, but it has rarely been applied to miscarriage analysis. In this study, we conducted a prospective study to evaluate the feasibility of CMA for genetic diagnosis of first-trimester miscarriage specimens. We successfully analyzed 551 fresh miscarriage specimens using single-nucleotide polymorphism (SNP) array. Among the specimens, 2.9% (16/551) had significant maternal cell contamination and were excluded from the study...
November 24, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27872414/effect-of-low-dose-aspirin-on-midluteal-phase-uterine-artery-blood-flow-in-patients-with-recurrent-pregnancy-loss
#18
Xiaomin Kang, Tongfei Wang, Liyin He, Haijing Xu, Zhilan Liu, Aimin Zhao
OBJECTIVES: The purpose of this study was to evaluate differences in uterine artery blood flow parameters and pregnancy outcomes, if any. An investigation was conducted to determine the effects of low-dose aspirin on uterine artery blood flow indices in patients with recurrent pregnancy loss. METHODS: This observational study included 353 Chinese women with a history of recurrent pregnancy loss and 85 women without a history of recurrent pregnancy loss (control group) from Ren Ji Hospital...
December 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27836685/differential-expression-profile-of-long-noncoding-rnas-in-human-chorionic-villi-of-early-recurrent-miscarriage
#19
Leilei Wang, Huaiyun Tang, Yun Xiong, Lisha Tang
Miscarriage is the spontaneous loss of a pregnancy before the fetus reaching viability, including all pregnancy losses from the time of conception until 24weeks of gestation. Three or more times of consecutive spontaneous miscarriages is defined as recurrent miscarriage (RM). The underlying causes cannot be confirmed in nearly 50% of RM patients. We investigated the differential expression of long noncoding RNAs (lncRNAs) in chorionic villi tissues of RM patients compared with normal women, and their possible involvement in the pathogenic pathways leading to RM...
January 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27816617/uterine-suspension-with-adjustable-sutures-for-difficult-laparoscopic-myomectomy
#20
Kuo-Hu Chen, Kok-Min Seow, Li-Ru Chen
STUDY OBJECTIVE: To assess whether transabdominal uterine suspension with adjustable sutures (USAS) is beneficial when performed concomitantly with laparoscopic myomectomy in patients with unfavorably localized leiomyomas in whom uterine manipulators are not an option. DESIGN: A retrospective cohort study (Canadian Task Force classification II-2). SETTING: A university teaching hospital. PATIENTS: Patients (N = 158) with posterior deep intramural, intraligamental, or cervical leiomyomas; 81 patients underwent USAS (suspension group), and 77 patients did not (control group) concomitantly with laparoscopic myomectomy...
November 2, 2016: Journal of Minimally Invasive Gynecology
keyword
keyword
26383
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"